Where is ASMS this year?

All activities will be held in the George R. Brown (GRB) Convention Center in Houston, Texas unless noted. ONLINE PLANNER with detailed schedule and all abstracts is now available to conference registrants.

What is ASMS conference?

Asilomar Conference on Mass Spectrometry This small conference is limited to 130 participants and takes place annually at the Asilomar Conference Center in Pacific Grove, CA. Fall Workshop This tutuorial workshop explores emerging technology for those seeking to learn the topic or who are new to the field.

How many students attend ASMS?

253 Alabama School of Math And Science / Number of students (2015–2016)

Chris Warford - Owner - ASMS, LLC | LinkedIn.

How many members are there in ASMS?

ASMS is managed by an elected Board of Directors consisting of nine members who each serve a two-year term.

What is GPA conference?

GPA Midstream's Technical Conference brings together the industry's technical community and offers educational sessions plus networking opportunities . The 2023 GPA Midstream Technical Conference concluded April 6 after a flurry of presentations, committee meetings and networking events.

What should be included in a conference booklet?

A conference booklet should contain things like: a foreword from the event organizers, a summary of the event and its schedule, a map of the venue, bios on the keynote speakers, a list of abstracts, information about sponsors or exhibitors, and a list of event participants.

How many students go to Alabama A&M?

Alabama A&M University is a medium-sized public university located on an urban campus in Normal, Alabama. It has a total undergraduate enrollment of 5,093 , and admissions are selective, with an acceptance rate of 90%.

How much does it cost to attend Alabama School of Math and Science?

Q: How much does it cost to attend ASMS? ASMS is a state-funded educational program, so there is no tuition, and room and board, as well as meals are paid for by the state. The annual student activity fee is approximately $1,575 and can be paid in installments.

How big is Alabama A&M school?

Alabama A&M University is home to 6,100 students , including undergraduate, graduate, and doctoral candidates.

Who are the ASMS presidents?

The past presidents of ASMS are: William S. Young 1953–1954. M. John O'Neal 1954–1956. William Priestley Jr. 1956–1958. R. August Friedel 1958–1960. Vernon H. Dibeler 1960–1962. Russell E. Fox 1962–1964. Norman D. Coggeshall 1964–1966. Henry M. Rosenstock 1966–1968. More items...

When was the Alabama School for Math and Science founded?

Nestled in Mobile's beautiful Old Dauphin Way Historic District, ASMS was founded by the Alabama State Legislature in 1989 to better prepare Alabama's future leaders.

Is A 3.7 GPA Competitive?

A 3.7 GPA substantially clears the unofficial benchmark that most colleges use for competitive admission (3.0) and is also higher than the baseline average for more selective schools (3.5).

A 3.8 GPA stands for a Grade Point Average of 3.8 on a 4.0 scale. It indicates that you've earned a predominantly A average in your courses. A 3.8 GPA is considered to be a very good GPA and is often an indicator of strong academic performance.

Which GPA do colleges care about?

Unweighted GPAs are reported on a 4.0 scale and consider all classes equal. Weighted GPAs are reported on a 5.0 scale and consider class difficulty when awarding grades. Colleges consider both when reading your application for admission.

64 TH ASMS Conference on Mass Spectrometry and Allied Topics

Transcription

1 64 TH ASMS Conference on Mass Spectrometry and Allied Topics June 5-9, 06, San Antonio, Texas Welcome to the 64th ASMS Conference on Mass Spectrometry and Allied Topics. Conference program activities and exhibit booths are in the Henry B. Gonzalez Convention Center. Corporate Member hospitality suites are located in the Grand Hyatt Hotel. Sponsors ASMS gratefully acknowledges the support of these companies. Mobile App and WiFi Opening Reception Table of Contents General Information... Hotels... 5 ASMS Board of Directors... 6 Interest Groups and Committees... 7 Awards... 8 Convention Center Floor Plans... Corporate Hospitality Suites... ASMS Corporate Members... 4 Program Acknowledgements... 9 Program Overview... 0 Webcasting Titles in the following sections are provided by authors. The complete abstracts are available online: Closing Event Conference Sponsor Contributors Advanced Energy ETP Electron Multipliers Fluid Management Systems IDEX Health & Science Microliter Analytical Supplies (A WHEATON Company) Sunday... 5 Monday Oral Sessions... 5 Monday Workshops... Tuesday Oral Sessions... 4 Tuesday Workshops Wednesday Oral Sessions... 4 Wednesday Workshops Thursday Oral Sessions Poster Overview Monday Posters Tuesday Posters... 9 Wednesday Posters... 9 Thursday Posters... 6 Index of Authors New Objective Pall Laboratory Thermo Fisher Scientific Zef Scientific 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

2 GENERAL INFORMATION Registration is open :00-5:00 pm on Saturday, 0:00 am - 8:00 pm on Sunday, and 7:0 am - 5:00 pm on Monday - Thursday. Attention Undergraduate Students and First Time (at ASMS) Graduate Students 4:00-5:00 pm, Sunday, Stars Ballroom, level Plan Your Strategy: What to See and Do at ASMS Sunday Tutorial Session, 5:00-6:0 pm Hall, level 5:00-5:45 pm Forensic Mass Spectrometry #TellMeSomethingIDontKnow PLENARY SESSIONS Monday Award Lecture, 4:45-5:0 pm Hall, level Award for a Distinguished Contribution in Mass Spectrometry Scott A. McLuckey Purdue University Tuesday Award Lecture, 4:45-5:0 pm Hall, level Biemann Medal Kristina Håkansson University of Michigan Facundo Fernandez Georgia Institute of Technology Glen Jackson West Virginia University 5:45-6:0 pm An Analyte s Journey from Solution into the Gas Phase Lars Konermann University of Western Ontario Sunday Conference Opening, 6:45-7:45 pm Hall, level level Welcome Vicki H. Wysocki The Ohio State University ASMS Vice President for Programs A Molecular Arsenal Against Ebola Virus Erica Ollmann Saphire The Scripps Institute-La Jolla Sunday Welcome Reception, 7:45-9:00 pm Poster/Exhibit Hall. Conference name badge is required. Thursday Plenary Lecture, 4:45-5:0 pm Hall, level Don t miss More than the Sum of its Parts: Collective Phenomena in Living Systems, from Single Molecules to Flocks of Birds William Bialek Princeton University ASMS Meeting, Wednesday, 4:45-5:0 pm Stars Ballroom, level Enjoy a beverage while you applaud awards, hear about new initiatives, and more! Closing Event, Thursday, 6:0-9:00 pm Briscoe Western Art Museum Let s celebrate! Stroll to the Briscoe for a western barbecue under the live oak trees of the terrace overlooking the San Antonio Riverwalk. View the exhibits which preserve and interpret the art, history, and culture of the American West. The evening continues with music, dancing and karaoke. Ticket is required, $0. PAGE 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

3 GENERAL INFORMATION Oral Sessions are 8:0-0:0 am and :0-4:0 pm Monday through Thursday. Level Session A (MOA, TOA, WOA, ThOA)... Hall Level Session B (MOB, TOB, WOB, ThOB)...Room Level Session C (MOC, TOC, WOC, ThOC)... Stars Session D (MOD, TOD, WOD, ThOD)...Stars - Session E (MOE, TOE, WOE, ThOE)... Stars 4 Session F (MOF, TOF, WOF, ThOF)... Hemisfair Session G (MOG, TOG, WOG, ThOG)... Hemisfair Session H (MOH, TOH, WOH, ThOH)... Hemisfair Oral Presentations are projected from ASMS computers running Microsoft Office. Speakers are required to use the ASMS computers for their presentations. Speakers must load presentations at least one day prior to their talks. The speaker room is, level. The room is open with a technician according to this schedule: Sunday: 0:00 am - 8:00 pm Monday through Thursday: 7:0 am - :00 pm Posters and Exhibit Booths are in the Poster/Exhibit Hall. The Hall is open: Sunday Reception...7:45 pm - 9:00 pm Monday - Wednesday...7:0 am - 8:00 pm Thursday...7:0 am - :00 pm Poster Set-Up is 7:0 am on the day scheduled. Refer to the poster numbers in this final program for board assignments. A counter for poster supplies is near the main entrance to the Hall. Poster Sessions are 0:0 am - :0 pm, Monday through Thursday. Poster Authors must be present at posters on scheduled days at these times. 0:0 am - :00 pm...odd-numbered posters :00 - :0 pm...even-numbered posters Presenters who must leave a poster unattended should post a return time. Presenters should wear Poster Presenter badges which are available at the poster supply counter. Posters should not be removed before 7:0 pm on Monday, Tuesday and Wednesday. Thursday posters should be removed at :0 pm. Lunch Concessions in the Poster/Exhibit hall offer a variety of options to dine and network while taking a break from posters. Concessions are open :00 am - :00 pm, Monday through Thursday. Exhibitors must staff exhibit booths as follows: Sunday Reception...7:45 pm - 9:00 pm Monday - Thursday...0:0 am - :0 pm Workshops are 5:45-7:00 pm on Monday, Tuesday, and Wednesday. Light refreshments are provided in the pre-function areas on level and level. Dinner Break 7:00-8:00 pm is time for a breath of fresh air before the opening of hospitality suites at 8:00 pm. Special Program for Undergraduate Students Sunday, 7:0-9:00 pm, Poster competition, Poster/ Exhibit Hall Monday, :0 am - :00 pm, Meet the Experts. Lunch tables reserved for undergraduate students in the Poster/ Exhibit Hall. Free vouchers for lunch will be provided at the tables. Arrive promptly at :0 am to obtain your voucher. Free WiFi Access is provided in the Poster/Exhibit Hall. Computers are provided at stations throughout the convention center. Conference Proceedings will be published online. Submission to the Proceedings does not constitute publication and does not jeopardize the rights of authors to publish contents of their submissions. Speaker web casting slides will be printed to PDF and used for speakers who fail to submit an extended abstract. Web Casting includes tutorial lectures, plenary lectures, and oral sessions. Web casting will be available to conference attendees for three months after the conference. ASMS does not retain rights to material included in web castings. To access the presentations, go to and login. The link to web casting is on the annual conference page. Corporate Hospitality Suites are open to all attendees from at least 8:00 - :00 pm Monday - Wednesday. Suites are also open during the day for one-on-one or small group meetings (no more than 5 people) by appointment only. Interested attendees should contact their sales representative for more information. Companies may also use their suites for breakfast seminars. Suites are located in the Grand Hyatt Hotel. Career Center is located in the Poster/Exhibit Hall. The Career Center is open to all conference attendees. Applicants and employers must enter resumes and employment opportunities online. There are computers in the center for searching the database of candidates and positions. Interview rooms must be reserved one day in advance. Sunday...7:45-9:00 pm Monday - Wednesday...7:0 am - 5:00 pm Thursday...7:0 am - :0 pm Guest Registration ($0) includes designated name badge and entrance to the Sunday evening reception. The badge does not gain entrance to oral sessions or the Poster/Exhibit Hall. Single Use/Family Restrooms are available on each level. Mother s Room is Room 5 (for mothers only). From the Ballroom Level proceed to the Hemisfair Ballroom foyer and take escalators down. Room 5 is on the right side of the foyer space. 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

4 GENERAL INFORMATION Corporate Breakfast Seminars are located in the convention center and at the Grand Hyatt. Reservations are required and may be made at company exhibit booths. MONDAY Company Convention Center Room Advanced Chemistry Development Room 4 Agilent Technologies (at Grand Hyatt) Lone Star Ballroom DEF Bruker Daltonics Room 5CD LECO Room 0A Matrix Science Room 0BC SCIEX Room 04A SCIEX Room 05 Shimadzu Room 0 Thermo Fisher Scientific (at Grand Hyatt) Republic ABC Waters Corporation (at Grand Hyatt) Texas Ballroom BC Waters Corporation Room 0BC Waters Corporation Room 0A TUESDAY Company Convention Center Room Agilent Technologies (at Grand Hyatt) Lone Star Ballroom DEF Biotage Room 5B Bruker Daltonics Room 5CD GL Sciences Room 0A LECO Room 0A Matrix Science Room 0BC MilliporeSigma Room 0BC New Objective Room 05 Prosolia Room 4 SCIEX Room 0A SCIEX Room 04A SCIEX Room 04BC Shimadzu Room 0 Thermo Fisher Scientific (at Grand Hyatt) Republic ABC Waters Corporation (at Grand Hyatt) Texas Ballroom BC Waters Corporation Room 0BC WEDNESDAY Company Convention Center Room Agilent Technologies (at Grand Hyatt) Lone Star Ballroom DEF Bruker Daltonics Room 5CD LECO Room 0A New Objective Room 05 SCIEX Room 0A SCIEX Room 04A SCIEX Room 04BC Shimadzu Room 0 Thermo Fisher Scientific (at Grand Hyatt) Republic ABC Waters Corporation (at Grand Hyatt) Texas Ballroom BC Waters Corporation Room 0BC THURSDAY Company Convention Center Room SCIEX Room 04A Shimadzu Room 0 Thermo Fisher Scientific Room 5CD Media Events are scheduled for members of the press and financial institutions. All will be held in the Grand Hyatt Hotel. Company Monday Grand Hyatt Hotel Location Bruker 8:00-9:00 am Texas Ballroom A Shimadzu 9:0-0:0 am Texas Ballroom EF SCIEX :00-:00 pm Lone Star Ballroom ABC Agilent Technologies :0-:0 pm Lone Star Ballroom DEF Thermo Fisher Scientific :00-4:00 pm Texas Ballroom D Waters Corporation 4:0-5:0 pm Texas Ballroom BC Conference Regulations Name badge is required for all conference sessions, including the Poster/Exhibit Hall and the employment center. No smoking is permitted in the convention center. All devices must be silenced and screens darkened in oral sessions. No photography or recording is allowed in oral sessions or in the poster/exhibit Hall. Parents. Planned conference sessions and hospitality suites may not be appropriate for children. Please respect the interests of your colleagues by allowing them to attend activities without disruption and without concern for the safety of children. Strollers, child backpack carriers or similar devices for child transport are prohibited in the Poster/Exhibit Hall and hospitality suites. Material presented or displayed at the ASMS Conference, including but not limited to orals, posters, workshops, exhibit booths and hospitality suites, is the intellectual property of the presenter and may not be recorded, photographed, quoted, disseminated or transmitted by summary in any form without express written authority of the author. The placement of advertising in the meeting area is prohibited. There are poster boards and tables in the Poster/Exhibit Hall for approved announcements. Hardware, accessories or any items for sale may be displayed only in corporate exhibit booths and hospitality suites. Designated publisher tables in the conference registration area are for the display of books and journals and must be reserved in advance. There are tables in the registration area for authors who wish to display their books. Authors may use a table to promote their books, sign copies, and speak with members. Table space must be reserved at conference registration. No organized activities (even off-site) other than those approved by ASMS are allowed during the conference week (5:00 pm on Sunday through 6:00 pm on Thursday). Corporate hospitality suites may be used during the daytime hours of 8:00 am 8:00 pm for one-on-one and small group meetings (no more than 5 persons per organization) by appointment only (no walk-ins). No music, programs, seminars, or refreshments may be included in these private, business meetings. Corporate or institutional logos on slides or posters may appear only one time in the presentation. PAGE 4 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

5 HOTELS Hotel Telephone Hotel Telephone. Convention Center (0) Crockett Hotel (0) Drury Inn & Suites Riverwalk (0) Emily Morgan (0) Fairfield Inn & Suites (0) Grand Hyatt San Antonio (0) Hilton Palacio del Rio (0) Homewood Suites by Hilton (0) La Quinta Inn & Suites (0) Menger Hotel (0) -46. Marriott Rivercenter (0) Marriott Riverwalk (0) Springhill Suites San Antonio (0) - 4. Westin Riverwalk (0) TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

6 ASMS GENERAL BOARD INFORMATION OF DIRECTORS President Jenny Brodbelt University of Texas Austin, TX Congratulations to these members who were elected to the ASMS Board Vice President for Programs Past President Susan T. Weintraub University of Texas Health Science Center San Antonio, TX Vice President for Programs Vicki H. Wysocki The Ohio State University Columbus, OH Richard A. Yost University of Florida Gainesville, FL Treasurer Vice President for Arrangements Jack Henion Advion, Quintiles and Cornell University Ithaca, NY Treasurer Patrick R. Griffin Scripps Research Institute Jupiter, Florida Ying Ge University of Wisconsin-Madison Madison, WI Member at Large for Education Secretary Yu Xia Purdue University West Lafayette, IN Member at Large for Education Igor Kaltashov University of Massachusetts Amherst, MA John A. McLean Vanderbilt University Nashville, TN Member at Large for Digital Communications Member at Large for Publications Facundo Fernandez Georgia Institute of Technology Atlanta, GA Member at Large for Digital Communications Brian Searle University of Washington Seattle, WA John R. Yates III Scripps Research Institute LaJolla, CA Staff Judith A. Sjoberg, Executive Director Jennifer Watson Cindi Pettit, Lola Priest, Miquela Sena Marin Walker, Brent Watson PAGE 6 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

7 ASMS INTEREST GROUPS AND COMMITTEES Interest Group Coordinators Analytical Laboratory Brett Phinney Managers Aliss Chien Bioinformatics for MS Sangtae Kim Meena Choi Biotherapeutics Damian Houde Ashley Ruth Clinical Chemistry Tim Garrett Brian Rappold Data Independent Ludovic Gillet Acquisition Jarrett Egertson Drug Metabolism & Kevin Bateman Pharmacokinetics Philip Tiller Energy, Petroleum & Mark Barrow Biofuels Lateefah Stanford Environmental Marc Engel Applications Chris Gill Exposomics David Balshaw Anthony Macherone Flavor, Fragrance and Walter Hammock Foodstuff David Schroeder Forensics & Adam Hall Homeland Security Guido Verbeck FTMS David Kilgour Don Smith Fundamentals Alessandra Ferzoco Michael Van Stipdonk H/D Exchange, Covalent Joshua Sharp Labeling & Cross Linking David Weis Imaging MS Vilmos Kertesz Raf Van de Plas Ion Mobility MS Erin Baker Stephen Valentine Ion Trap MS Daniel E. Austin Zheng Ouyang Lipids & Lipodomics Christer Esjing Todd Mitchell LC/MS Related Topics Michael Bereman Brent Dixon Metabolomics Andrew Patterson Tim Garrett Metal Ion Coordination Cheng Lin Chemistry Alex Shvartsburg Oligonucleaotides & Patrick Limbach Nucleic Acids Laixin Wang Pharmaceuticals Christine Gu Matthew Schenauer Photoionization MS Jack Syage Ralf Zimmerman Polymeric Materials Stephen Rumbelow Gyorgy Vas Regulated Bioanalysis Jian Wang Undergraduate Elaine Marzluff Research in MS Megan Gessel Young Mass Violet Lee Spectrometrists Kristin Wildsmith Committees Asilomar Sharon Pitteri, Chair Conference Matt Bush (ACMS) Lingjun Li Susan Weintraub Corporate Jack Henion, Chair Liaison Susan Weintraub Martin Eysberg, Antec Carol Harp, Agilent Technologies Michael McGinley, Phenomenex Lance Nicolaysen, Waters Corporation Bobbie Jo Seyler, Sigma Aldrich Paul Speir, Bruker Daltonics Digital Brian Searle, Chair Communications Ashley Ruth Bruce Pascal Brett Phinney Dasari Surendra Susan Van Riper Education Igor Kaltashov, Chair Allessandra Ferzoco Damian Houde Dil Ramanathan Elizabeth Stemler Nominating Gary Glish, Chair Ben Garcia Michael Easterling Ljiljana Pasa-Tolic David Tabb Publications Facundo Fernandez, Chair Lorna De Leoz Leslie Hicks Richard Perry Will Thompson Joseph Loo (ex officio) Sanibel Erin Baker, Chair Conference Fanyu Meng Victor Ryzhov Patrick Griffin 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

8 GENERAL ASMS AWARDS INFORMATION Award for a Distinguished Contribution in Mass Spectrometry 06 Recipient: Scott A. McLuckey Award Lecture: 4:45 pm Monday, Hall, level Dr. Scott A. McLuckey is the recipient of the 06 ASMS Award for a Distinguished Contribution in Mass Spectrometry for his pioneering contributions to the understanding of the gas-phase ion/ion reactions of polyatomic molecules and their applications in analytical mass spectrometry. Gas-phase ion chemistry has played a central role in mass spectrometry since its inception. Unimolecular and ion/neutral reactions, for example, have been observed, studied, and used throughout the entire history of molecular mass spectrometry. While the study of ion/ion reactions originated with J.J. Thomson and has been pursued within the context of plasma chemistry, atmospheric chemistry, and chemistry in the interstellar medium, ion/ion reactions have not been exploited in mainstream mass spectrometry until relatively recently. Keys to this development have been the introduction of techniques capable of generating multiply charged ions, electrospray being chief among them, and the use of electrodynamic ion traps, which can store efficiently oppositely charged ions in overlapping time and space. McLuckey and co-workers, beginning at Oak Ridge National Laboratory in the mid-990s and continuing at Purdue University since 000, initiated and sustained a line of research employing electrospray and ion traps that has revealed a wide and expanding array of ion/ion reactions that significantly expand the scope of tandem mass spectrometry, particularly in biological mass spectrometry. Dr. McLuckey s efforts in this area have focused both on understanding the dynamics of ion/ion reactions and on developing ion/ion reactions for analytical applications. He and his co-workers demonstrated that ion/ion reactions in ion traps can be both highly efficient and fast. Furthermore, ion/ion reactions are universal in that some form of reaction will occur for any combination of oppositely charged ions. Dr. McLuckey s initial work was focused on proton transfer, and to a lesser extent, electron transfer reactions. Proton transfer reactions have been demonstrated to be particularly useful for charge state manipulation and have been used for mixture analysis, concentrating charge, inverting ion charge, etc. Electron transfer has proved to be particularly useful for generating structural information. For example, the discovery in Donald Hunt s lab of reagent anions that transfer electrons to peptide and protein cations led to the development of electron transfer dissociation. These developments, which leveraged much of what was known about proton transfer ion/ion reactions in ion traps, catalyzed the commercial introduction of ion/ion reactions tools that rely on electrospray and ion traps. In recent years, McLuckey s group has expanded ion/ion chemistry to include selective metal ion insertion/removal and functional group specific covalent bond formation. Collectively, these chemistries, along with proton and electron transfer, significantly expand the power of MS/MS in characterizing peptides, proteins, oligonucleotides and lipids. The wide-ranging efforts of McLuckey and his colleagues in instrumentation, fundamentals, and applications of ion/ion reactions over the past two decades constitute a distinguished contribution to mass spectrometry. Dr. Scott A. McLuckey is the John A. Leighty Distinguished Professor of Chemistry at Purdue University, West Lafayette, IN. Ron A. Hites Award Outstanding Research Publication in JASMS Award Presentation: ASMS Meeting, 4:45 pm Wednesday, Stars Ballroom, level The Ron Hites Award recognizes an outstanding publication of original research, based on a paper s innovative aspects, technical and presentation quality, likely stimulation of future research and impact on future applications. The award is named to honor Professor Ron Hites of Indiana University, who led the creation of JASMS in 988 while president of ASMS. The award includes $,000 and a certificate for each author. The 06 award recognizes Kevin Pagel, Max Planck Society Berlin, and, co-authors Waldemar Hoffmann and Johanna Hofmann for their paper Energy-Resolved Ion Mobility- Mass Spectrometry: A Concept to Improve the Separation of Isomeric Carbohydrates: JASMS (04) 5, Left to right Johanna Hofmann, Kevin Pagel, and Waldemar Hoffmann PAGE 8 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

9 ASMS AWARDS BIEMANN MEDAL 06 Recipient: Kristina Kicki Håkansson Award Lecture: 4:45 pm Tuesday, Hall, level Dr. Kristina Kicki Håkansson has been awarded the 06 Biemann Medal for her contributions related to her work to develop and elucidate the mechanisms of electron-based activation methods, including electron capture dissociation, electron detachment dissociation, and electron induced dissociation. She has applied these electron-based activation methods to identify and characterize biological molecules from a number of classes, including peptides, oligonucleotides, and oligosaccharides. The challenges associated with structural characterization of increasingly complex biological molecules has inspired the development of many new activation methods. Ones involving the attachment or detachment of an electron to an ion have shown great promise and have motivated renewed interest in gas-phase radical ion chemistry, both areas which are hallmarks of the Håkansson group. Dr. Håkansson has focused on deciphering the mechanisms of electronactivated dissociation and shown the outstanding utility of these methods for analysis of nucleic acids, oligosaccharides, and peptides including ones with labile modifications like phosphorylation. Negative ion electron capture dissociation (discovered in the Håkansson laboratory) in particular has shown excellent performance for characterization of phosphorylated and sulfated peptides ionized in the negative mode. Her group has also shown that electron-activated dissociation methods are gentle enough to allow preservation of higher order structures of nucleic acids. Dr. Håkansson is a professor in the Department of Chemistry at the University of Michigan in Ann Arbor. 06 RESEARCH AWARDS Award Presentation: 4:45 pm Tuesday, Hall, level The Research Awards are fully funded by Thermo Fisher Scientific and Waters Corporation in the amount of $5,000 each. Sponsored by Thermo Fisher Scientific Sponsored by Waters Corporation Ronghu Wu Georgia Institute of Technology Etienne Garand University of Wisconsin- Madison 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9

10 GENERAL ASMS AWARDS INFORMATION 06 PostDoctoral Awards Award Presentation: ASMS Meeting, 4:45 pm Wednesday, Stars Ballroom, level Four awards in the amount of $0,000 each are intended to promote the professional career development of postdoctoral fellows in the field of mass spectrometry. Activities funded by these awards include conference and workshop attendance, travel to other mass spectrometry laboratories, purchase of books and/or software. The awards are open to ASMS members who are postdoctoral fellows within three years of completing a Ph.D. or equivalent degree. Applicants must be currently appointed as a postdoctoral fellow in North America (e.g., in academia, industry, a government or national laboratory or at a research institute). Details and an application are posted to asms.org. John Cahill Oak Ridge National Laboratory Andrew DeBlase Purdue University Catherine Going Stanford University Pengyuan Liu The Wistar Institute 06 student awards Award Presentation: ASMS Meeting, 4:45 pm Wednesday, Stars Ballroom, level ASMS supports up to ten awards of $,000 for graduate students and ten awards of $500 for undergraduates. Applications and details for these awards are posted to asms.org. The deadline for submission is January 5. Graduate Student Awards Undergraduate Student Awards Xibei Dang, Florida State University Zachery Gregorich, University of Wisconsin-Madison Nathan Hendricks, University of California, Riverside Johanna Hofman, Max Planck Society Ramsunder Iyer, University of Tennessee Brent Kuenzi, University of South Florida Anumita Saha-Shah, Indiana University Willem Duckworth, Clarkson University Carlo Eikani, Saint Mary's College of California Matthew Kazaleh, University of Florida Yekaterina Kori, University of Massachusetts Amherst Rebecca Marin, Florida International University Rachel Martini, University of Michigan Evan Perez, Duquesne University Stephen Sciuto, The University of Toronto Candice Ulmer, University of Florida Yejing Weng, Chinese Academy of Sciences PAGE 0 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

11 HENRY B. GONZALEZ CONVENTION CENTER LEVEL - BALLROOM LEVEL Sessions C (Stars ) Session D (Stars -) Session E (Stars 4) Session F (Hemisfair ) Session G (Hemisfair ) Session H (Hemisfair ) Workshops, Breakfast Seminars (Rooms HEMISFAIR BALLROOM STARS AT NIGHT BALLROOM - 4 LEVEL - MEETING LEVEL Sessions B (Room ) Workshops, Breakfast Seminars (Rooms 0-5) Speaker Room (Room ) LEVEL - STREET LEVEL Posters, Exhibits, Career Center (Halls - ) Session A, Plenary Sessions (Hall ) HALL HALL Registration HALL Market Street 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

12 N70 45 N70 45 N70 45 N Sales Office ES Room DUMPSTER DUMPSTER DUMPSTER FREEMAN SERVICE LOADING DOCK FH FX FX H8 H40 HD07A FIRE EXIT Storage FH To/From Concourse Level Above H5 HC5 FIRE EXIT FIRE EXIT FIRE EXIT FIRE EXIT HD * * * FX O/H DOOR Escalator FX FX FX FH 48 FX FH Escalator H9 To/From Concourse Level Above O/H DOOR FH FH FH POSTER/EXHIBIT GENERAL INFORMATION HALL FH FH FX FH FX FH FX FH FX Special Posters & Announcements Apps & Technology Spotlight Posters FH FX FS ENTRANCE FX FH FS FS FS EXIT ONLY Career Center FX FH FX FH ceiling height 9'4" ENTRANCE EXIT ONLY FH LOADING DOCK LOADING DOCK LOADING DOCK PAGE 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

13 HOSPITALITY SUITES, GRAND HYATT HOTEL Grand Hyatt, nd Floor Grand Hyatt, 4 th Floor 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

14 ASMS GENERAL CORPORATE INFORMATION MEMBERS COMPANY POSTER / Library BOOTH st Detect Devices 50 ACS Publications Library Adeptrix Corporation Poster 04 Advanced Chemistry Development (ACD/Labs) Advanced Chromotography 59 Advanced Energy 9 Advion Inc. 8 Agilent Technologies Poster 00 Alliance Pharma, Inc. 4 Analytical Parts Supply, LLC 4 Analytical Sales and Services, Inc. Poster 07 Analytical Scientific Instruments 08 Anasys Instruments 57 Anest Iwata 70 Antec 700 Apricot Designs, Inc. 6 Ardara Technologies LP 69 Avanti Polar Lipids, Inc. 47 BioChromato, Inc. 809 BIOCRATES Life Sciences AG Biognosys Poster 09 Bioinformatics Solutions Inc. Poster 8 SUITE in Grand Hyatt Hotel Breakfast Poster 70 Room 4, Mon (6/6) Lone Star Ballroom DEF Lone Star Ballroom DEF, Mon-Wed (6/6-6/8) Biotage 00 Room 5B, Tue (6/7) Bonna-Agela Technologies, Inc. Poster 709 Bruker Daltonics 9 Texas Ballroom A Room 5CD, Mon-Wed (6/6-6/8) Cambridge Isotope Labs 800 Canadian Life Science Poster 0 Cayman Chemical Company 80 Cerno Bioscience 9 Chemyx, Inc. 5 CMP Scientific, Inc. 60 Compare Networks Library CovalX 50 Covance 607 Cryoxtract Poster 40 CSS Analytical Co. Inc. 50 CTC Analytics AG 409 Denator AB 56 PAGE 4 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

15 ASMS CORPORATE MEMBERS COMPANY POSTER / Library BOOTH Detector Technology, Inc. 500 SUITE in Grand Hyatt Hotel Deurion Poster Crockett A Digital Proteomics Poster 60 Drummond Scientific 507 EBARA Technologies 6 Edwards Vacuum 504 Elforlight Ltd. 98 El-Mul Technologies 80 e-msion, Inc. 8 ESI Source Solutions 8 ETP Electron Multipliers/Ion Detect 6 Excellims Corporation 705 Extrel Poster Fluid Management Systems 6 Fortis Technologies Ltd Poster 5 Genedata 07 Genetic Engineering & Biotechnology News Library Genovis Poster 600 GenTech Scientific, Inc. 506 GERSTEL, Inc. Poster 65 Breakfast GL Sciences Inc. Room 0A, Tue (6/7) Golden West Biologicals, Inc. 0 Grenova Poster Hamamatsu Corporation Poster 7 Hamilton Robotics Poster 605 Harris Corp Poster 7 HighChem 58 Horizon Technology, Inc. 68 HTX Technologies, LLC 89 HVM Technology 70 IDEX Health & Science Poster 400 ilab Solutions 404 IMCS 78 Imtakt USA Institute for Systems Biology 805 INTAVIS Bioanalytical Instruments AG 07 International Ceramic Engineering 79 International Equipment Trading Ltd. 40 International Labmate Library ionbench 49 IonSense, Inc. Poster 9 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

16 ASMS GENERAL CORPORATE INFORMATION MEMBERS COMPANY POSTER / Library BOOTH ION-TOF GmbH Poster 58 IsoSciences 406 JEOL USA, Inc. 9 JPT Peptide Technologies 405 LEAP Technologies 6 SUITE in Grand Hyatt Hotel Breakfast LECO Corporation Poster 05 Room 0A, Mon-Wed (6/6-6/8) Linden CMS GmbH Mac-Mod Analytical 88 Markes International Poster 78 MasCom Technologies 508 MassTech Inc. 49 Matrix Science Room 0BC, Mon-Tue (6/6-6/7) Matsusada Precision Inc. 0 McKinley Scientific MeCour Temperature Control 79 MestreLab Research 50 Microliter Analytical Supplies (A WHEATON Company) 604 MilliporeSigma Poster 7 Room 0BC, Tue (6/7) Mo Bio Laboratories Moeller Medical GmbH 54 MRM Proteomics Inc MS Noise 59 mspec group 09 MStm 06 nanoliter, LLC Poster 46 Nest Group, The Poster New England Peptide, Inc. 7 Mission A New Objective, Inc. Poster Room 05, Tue-Wed (6/7-6/8) NIST 08 Oerlikon Leybold Vacuum 509 Omni Enclosures 5 Omni International 5 OPOTEK, Inc. 606 Optimize Technologies, Inc. Poster 608 Optys Tech Corporation 45 Owlstone, Inc. 407 Pall Laboratory 04 Parker Balston/Hannifin 48 PEAK Scientific Poster 69 Peeke Scientific 64 Perfinity Biosciences 7 PerkinElmer 48 PAGE 6 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

17 ASMS CORPORATE MEMBERS COMPANY POSTER / Library BOOTH Pfeiffer Vacuum Poster 0 Phenomenex 6 Phoenix S&T, Inc. 0 PHOTONIS Poster 40 Physical Electronics Poster 8 Phytronix Technologies, Inc. 0 Presco Incorporated 77 SUITE in Grand Hyatt Hotel Pressure BioSciences, Inc. 89 Mission B Promega Corporation 68 Breakfast Prosolia, Inc. Poster 4 Room 4, Tue (6/7) Protea Biosciences, Inc. 5 Protein Metrics Inc. 50 Proteome Sciences Poster Proteome Software Inc. Proton Onsite 05 PTM Biolabs, Inc. 5 PurSpec Technologies, Inc. 408 Pursuits Instrument Limited 80 Qioptiq, An Excelitas Technologies Co 707 Rapid Novor Inc. Poster 06 Restek Corporation 67 Resyn Biosciences 704 RMI Laboratories 4 Samin Science Co., Ltd 90 Science/AAAS Library Scientific Instrument Services Poster 8 Scientific Systems, Inc. 7 SCIEX 0 Lone Star Ballroom ABC Room 0A, Tue-Wed (6/7-6/8) Room 04A, Mon-Thu (6/6-6/9) Room 04BC, Tue-Wed (6/7-6/8) Room 05, Mon (6/6) Shimadzu Scientific Instruments, Inc. Poster 0 Texas Ballroom EF Room 0, Mon-Thu (6/6-6/9) Shimifrez Inc. 708 Sierra Analytics 4 Silantes GmbH 60 Sound Analytics 70 Spark Holland 55 SpectralWorks Limited Poster 05 Spectroscopy 40 Spectroswiss Spellman High Voltage TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

18 ASMS GENERAL CORPORATE INFORMATION MEMBERS COMPANY POSTER / Library BOOTH SUITE in Grand Hyatt Hotel Springer Science + Business Media SunChrom GmbH 70 Superior Technical Ceramics 66 SYFT Technologies Poster 609 Tecan Poster 0 The Analytical Scientist Library Thermo Fisher Scientific 9 Texas Ballroom D and Republic ABC Tofwerk AG 5 Tosoh Bioscience 4 Trajan Scientific and Medical Poster 40 Seguin AB Veritomyx 88 VICI Valco Instruments 09 VRS 0 VUV Analytics 900 Waters Corporation Poster 0 Texas Ballroom BC Wiley Library XPC Corporation 0 Zef Scientific Inc. 60 Zhejiang Haochuang Biotech Co., Ltd Poster 86 Breakfast Room 5CD, Thu (6/9) Republic ABC, Mon-Wed (6/6-6/8) Room 0A, Mon (6/6) Room 0BC, Mon-Wed (6/6-6/8) Texas Ballroom BC, Mon-Wed (6/6-6/8) PAGE 8 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

19 PROGRAM ACKNOWLEDGEMENTS Vice President for Programs Vicki H. Wysocki The Ohio State University Vice President for Programs Student Assistants Graduate students assist with many aspects of the conference, including registration, oral and poster sessions, and the employment center. The students each receive a stipend to help with their conference travel expenses. Program Committee Jon Amster Matthew Bernier Sebastian Boecker Kevin Clark Joshua Coon Prabha Dwivedi David Fischler Jay Forsythe Asiri Galhena David Gaul Joshua Gilbert Amanda Hummon Hongwu Jing Franklin E. Leach III Ron Orlando Ljiljana Pasa-Tolic Dennis R. Phillips Jessica Prenni Nicholas Seyfried David Smalley Kasi V. Somayajula Molly Soper Jeff Spraggins Frederick Strobel Rachel Stryffeler Cameron Sullards Matthew Torres Ronghu Wu Vicki Wysocki Rick Yost An Zhou Session Chairs Theodore Alexandrov Daniel Amador-Noguez Alison E. Ashcroft Silvia Balbo David M. Balshaw Candice Bridge Corey D. Broeckling Nicholas Brunelli Iain D. G. Campuzano Natalie Castellana Matthew M. Champion Hyung Won Choi Stephanie Cologna Sheena D'Arcy W. Alexander Donald Ashok R. Dongre Livia D. Eberlin Jim Edwards Marc E. Engel Katherine L. Fiedler John Froehlich Juan F. García-Reyes Wendell P. Griffith Patrick G. Hatcher Michael L. Heien Shawna Hengel Martin F. Jarrold Hilkka Kenttamaa John S. Klassen Paul Kowalski Heather C. Kuiper Cris Lapthorn Franklin E. Leach III Young Jin Lee Jennifer Liu Xiaowen Liu Ginger Milne Catherine Minogue Nina Morgner Amber L. Mosley Christopher C. Mulligan John P. O'Brien Andrew K. Ottens Kevin Pagel Juri Rappsilber Nichole Reisdorph Da Ren Jinhua Ren Thomas Rizzo Hannes L. Röst Ashley Ruth Bindesh Shrestha Arpad Somogyi George Stafford John R. Stutzman John E. P. Syka Jenny VanEyk Jian Wang Naidong Weng Michael Westphall Si Wu Yang Yuan Alla Zelenyuk Mowei Zhou Workshop Organizers Daniel Austin Erin Baker Mark Barrow Nuno Bandeira Kevin Bateman Michael Bereman Andrey Bondarenko Achille Cappiello Allis Chien Brent Dixon Meena Choi Eric Deutsch Dawn Dufield Charles Edmonds Christer Ejsing Jarrett Egertson Marc Engel Alessandra Ferzoco Valerie Gabelica Hongying Gao Fabio Garofolo Tim Garrett Megan Gessel Ludovic Gillet Ying Ge Chris Gill Tim Griffin Christine Gu Damian Houde Walter Hammack Vilmos Kertesz David Kilgour Michael MacCoss Anthony Macherone Luis Mendoza Mehdi Moini Sangtae Kim Violet Lee Cheng Lin Pat Limbach Elaine Marzluff Yehia Mechref Todd Mitchell Ron Orlando Zheng Ouyang Andrew Patterson Brett Phinney Brian Rappold Ashley Ruth Stephen Rumbelow Lateefah Stanford Nalini Sadagopan Matthew Schenauer David Schroeder Salvatore Sechi Joshua Sharp Douglas Sheeley Bindesh Shrestha Alexandre A. Shvartsburg Vincent Sica Don Smith Jack Syage Paul Thomas Philip Tiller Gyorgy Vas Jian Wang Laixin Wang Kristin Wildsmith Christine Wu Stephen Valentine Raf Van de Plas Michael Van Stipdonk Gyorgy Vas Guido F. Verbeck David Weis Nathan Yates Ralf Zimmerman 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9

20 GENERAL PROGRAM INFORMATION OVERVIEW Saturday 9:00 am - 4:0 pm Short Courses :00-5:00 pm Registration Sunday 9:00 am - 4:0 pm Short Courses 0:00 am - 8:00 pm Registration 4:00-4:45 pm Attention: First-time Graduate Students and Undergraduate Students Plan your Strategy: What to See and Do at ASMS, Stars Ballroom, level 5:00-6:0 pm Tutorial Lectures, Hall, level 5:00-5:45 pm Forensic Mass Spectrometry #TellMeSomethingIDontKnow Facundo Fernandez Georgia Institute of Technology Glen Jackson West Virginia University 5:45-6:0 pm An Analyte s Journey from Solution into the Gas Phase Lars Konermann University of Western Ontario 6:45-7:45 pm Conference Opening, Hall, level Vicki Wysocki (The Ohio State University), ASMS Vice President for Programs A Molecular Arsenal Against Ebola Virus Erica Ollmann Saphire The Scripps Institute-La Jolla 7:45-9:00 pm Welcome Reception in the Poster/Exhibit Hall Undergraduate Student Poster Competition PAGE 0 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

21 PROGRAM OVERVIEW Monday 7:0 am - 5:00 pm Registration 8:0-0:0 am Oral Sessions MOAam: Synthetic Polymers, Hall, level MOBam: Fundamentals: Ion-Ion and Ion-Neutral Interactions, Room, level MOCam: Ion Mobility: Small Molecules, Pharmaceuticals, and DMPK, Stars Ballroom, level MODam: Instrumentation: FTMS, Stars Ballroom -, level MOEam: Diagnostic Clinical Chemistry, Stars Ballroom 4, level MOFam: Informatics: Discovery Proteomics, Hemisfair Ballroom, level MOGam: Metabolomics: Untargeted Profiling, Hemisfair Ballroom, level MOHam: Membrane Protein MS, Hemisfair Ballroom, level 0:0 am - :0 pm Poster Session and Exhibits, Monday Posters, Poster/Exhibit Hall, level Odd-number posters present 0:0 am - :00 pm. Even-number posters present :00 - :0 pm. :0 :00 pm: Undergraduate students look for reserved tables and free lunch vouchers to Meet the Experts :0-4:0 pm Oral Sessions MOApm: Food Safety and Chemistry: Foodomics, Allergens, Bacteria, Foods, Hall, level MOBpm: Fundamentals: Ion Spectroscopy, Room, level MOCpm: Instrumentation: New Developments in Ionization and Sampling, Stars Ballroom, level MODpm: Antibodies and Antibody Drug Conjugates, Stars Ballroom -, level MOEpm: Data Independent Acquisition: Innovative Methods and Applications, Stars Ballroom 4, level MOFpm: Informatics: Metabolomics, Hemisfair Ballroom, level MOGpm: Nucleic Acid MS, Hemisfair Ballroom, level MOHpm: Covalent Labeling and Chemical Crosslinking, Hemisfair Ballroom, level 4:45-5:0 pm Award Lecture, Hall, level Award for a Distinguished Contribution in Mass Spectrometry Scott A. McLuckey Purdue University 5:45-7:00 pm Workshops There are light refreshments in the common areas. 0 Top-Down Proteomics: Ready for Primetime? Room 0, level 0 Next Generation LC-MS: Critical Insights & Future Perspectives, Room, level 0 Art and Cultural Heritage Mass Spec Applications, Room 5A, level 04 Bioinformatics: Challenges & Opportunities in Proteogenomics (Bioinformatics for MS), Room 5B, level 05 Environmental Analysis: Emerging Topics (Environmental Applications Interest Group), Room 5C, level 06 Metal Cationization in MS/MS of Biomolecules (Metal Ion Coordination Chemistry Interest Group), Room 5D, level 07 Proteomics Informatics for the Trans-Proteomic Pipeline, Room 0A, level 08 Metabolomics: Emerging Technologies for Continued Innovation (Metabolomics Interest Group), Room 0BC, level 09 Polymer MS Technology: Advancements and Discussion (Polymeric Materials Interest Group), Room 0A, level 0 MS Analysis of Antibody-Drug Conjugates (Pharmaceuticals Interest Group), Room 0BC Protocol Repositories for Proteomics and Metabolomics (Analytical Lab Managers Interest Group), Room 0A, level Miniaturization of Ion Traps and Related Devices (Ion Trap Interest Group), Room 0BC MS Career Options: How to Kick-Start your Career (Young Mass Spectroscopists Interest Group), Room 04, level 4 System Performance: Tracking through Statistical QC Monitoring (LC/MS & Related Topics Interest Group), Room 05, level 7:00-8:00 pm Dinner Break After 8:00 pm Corporate Hospitality Suites, Grand Hyatt Hotel 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

22 GENERAL PROGRAM INFORMATION OVERVIEW Tuesday 7:0 am - 5:00 pm Registration 8:0-0:0 am Oral Sessions TOAam: Energy, Petroleum, and Biofuels: Instrumentation and Method Development, Hall, level TOBam: Fundamentals: Metal Ion Cationization, Metal-Ligand Interactions and Catalysis, Room, level TOCam: HRMS for Quantitation in Drug Discovery, Development and Beyond, Stars Ballroom, level TODam: Imaging: Instrumentation & Method Development, Stars Ballroom -, level TOEam: Quantitative Proteomics in Systems Biology, Stars Ballroom 4, level TOFam: Instrumentation: non-ft based Analyzers, Hemisfair Ballroom, level TOGam: Lipids and Profiling, Hemisfair Ballroom, level TOHam: Native MS in Structural Biology, Hemisfair Ballroom, level 0:0 am - :0 pm Poster Session and Exhibits, Tuesday Posters, Poster/Exhibit Hall Odd-number posters present 0:0 am - :00 pm. Even-number posters present :00 - :0 pm. :0-4:0 pm Oral Sessions TOApm: Environmental: New Instrumentation and Approaches, Hall, level TOBpm: New Developments in Ion Detection, Room, level TOCpm: Quantitative Analysis in Drug Discovery and Development, Stars Ballroom, level TODpm: Ion Mobility, FAIMS & DMS: New Developments & Applications, Stars Ballroom - TOEpm: Qualitative and Quantitative Analysis of Post-translational Modifications, Stars Ballroom 4, level TOFpm: Imaging: Computational Methods and Analysis, Hemisfair Ballroom, level TOGpm: Metabolomics: New Technologies and Applications, Hemisfair Ballroom, level TOHpm: Protein-Ligand Interactions, Hemisfair Ballroom, level 4:45-5:0 pm Award Lecture, Hall, level Kristina Kicki Håkansson University of Michigan 5:45-7:00 pm Workshops There are light refreshments in the common areas 0 Glycoproteomics: Site Specific Glycan Analysis, Room 0, level 0 Ion Mobility: How to Interpret the Data (Ion Mobility MS Interest Group), Room, level 0 H/D Exchange, Covalent Labeling & Cross-Linking (H/D Exchange, Covalent Labeling & Cross-Linking Interest Group), Room 5A, level 04 Food Safety & Security: HRMS Applications (Flavor, Fragrance & Foodstuff Interest Group), Room 5B, level 05 Microcontrollers and Microcomputers: Emerging Technologies, Room 5C, level 06 DNA/RNA Adducts: Assay Development in Detection and Quantification (Oligonucleotides and Nucleic Acids Interest Group), Room 5D, level 07 Petroleum and Biofuels: Handling the Data (Energy, Petroleum & Biofuels Interest Group), Room 0A, level 08 Metabolism of Biotherapeutics: When, Why and How? (DMPK Interest Group), Room 0BC, level 09 Modification of Commercial Instruments for Fundamental Research (Fundamentals Interest Group), Room 0A, level 0 Lipidomics in the Era of Systems Biology: The Big Fat Challenges (Lipids and Lipidomics Interest Group), Room 0BC, level Undergraduate Research in Mass Spectrometry (Undergraduate Research in MS Interest Group), Room 0A, level The Chorus Project: Sustainable Cloud Solution for MS Data, Room 0BC, level Data Independent Acquisition (Data Independent Acquisition Interest Group), Room 04, level 4 Good Manufacturing Practice (GMP); Mass Spectrometric Instrument Qualification, Room 05 7:00-8:00 pm Dinner Break After 8:00 pm Corporate Hospitality Suites, Grand Hyatt Hotel PAGE 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

23 PROGRAM OVERVIEW Wednesday 7:0 am - 5:00 pm Registration 8:0-0:0 am Oral Sessions WOAam: Energy, Petroleum and Biofuels: Structure, Quantification, and Data Analysis, Hall level WOBam: Fundamentals: Energetics and Mechanisms of Uni and Bimolecular Reactions, Room, level WOCam: Imaging: Pharmaceuticals and Metabolites, Stars Ballroom, level WODam: Instrumentation: Miniaturization of MS, Stars Ballroom -, level WOEam: Biomarkers: Qualitative Analysis, Stars Ballroom 4, level WOFam: Informatics: Multiomics Integration and Application, Hemisfair Ballroom, level WOGam: MS in the QC Lab, Hemisfair Ballroom, level WOHam: Macromolecular Complexes, Hemisfair Ballroom, level 0:0 am - :0 pm Poster Session and Exhibits, Wednesday Posters, Poster/Exhibit Hall Odd-number posters present 0:0 am - :00 pm. Even-number posters present :00 - :0 pm. :0-4:0 pm Oral Sessions WOApm: Exposomics: Targeted, Untargeted and Bioinformatics Methodologies, Hall, level WOBpm: Fundamentals: Molecular Modeling and Quantum Mechanical Calculations in IM and MS, Room, level WOCpm: Environmental: Emerging Contaminants, Stars Ballroom, level WODpm: Imaging: Biomedical Applications, Stars Ballroom -, level WOEpm: Top Down Protein Analysis, Stars Ballroom 4, level WOFpm: MS in the Regulatory Environment, Hemisfair Ballroom, level WOGpm: Carbohydrates, Hemisfair Ballroom, level WOHpm: New Separations Approaches Coupled to MS, Hemisfair Ballroom, level 4:45-5:0 pm ASMS Meeting, Stars Ballroom, level : Awards, board reports, wine, beer, soft drinks - and more! 5:45-7:00 pm Workshops There are light refreshments in the common areas. 0 Bioanalysis: Current Status of Strategy and Practice of a Tiered Approach (Regulated Bioanalysis Interest Group), Room 0, level 0 Large-Scale Analysis of MS Big Data: From Data to Knowledge and Back, Room, level 0 FTMS: Day-to-Day Concerns for High Resolution Mass Analysis (FTMS Interest Group), Room 5A, level 04 Novel Mass Spectrometry Instrumentation: Moving into the Hands of Practitioners (Forensics & Homeland Security Interest Group), Room 5B, level 05 Photoionization: New Developments (Photoionization MS Interest Group), Room 5C, level 06 The NIH Review and Funding Process, Room 5D, level 07 Entrepreneurship: Creating a Job in Mass Spectrometry, Room 0A, level 08 Protein Quantitation (Absolute) by LC-MS: Biomarker and Biotherapeutic, Room 0BC, level 09 Isomeric Glycans: Characterization & Quantitation, Room 0A, level 0 Protein Therapeutics: Characterization using MS (Biotherapeutics Interest Group), Room 0BC, level The Exposome: MS-based Metabolomic Workflows to Characterize the Exposome (Exposomics Interest Group), Room 0A, level Biomarker Translation: Quality Control & Quality Assurance (Clinical Chemistry Interest Group), Room 0BC, level Imaging MS: Present and Future of Multimodal Studies (Imaging MS Interest Group), Room 04, level 4 Galaxy for Proteomics Data Analysis: An Interactive Demonstration, Room 05, level 7:00-8:00 pm Dinner Break After 8:00 pm Corporate Hospitality Suites, Grand Hyatt Hotel 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

24 GENERAL PROGRAM INFORMATION OVERVIEW Thursday 7:0 am - 5:00 pm Registration 8:0-0:0 am Oral Sessions ThOAam: New Concepts for Forensic MS, Hall, level ThOBam: Fundamentals: Photodissociation, Room, level ThOCam: New Developments in Ionization and Sampling for DMPK, Stars Ballroom, level ThODam: Translational Success with MS, Stars Ballroom -, level ThOEam: Glycopeptides and Glycoproteins, Stars Ballroom 4, level ThOFam: Informatics: Targeted Proteomics and DIA, Hemisfair Ballroom, level ThOGam: Application of Stable Isotope Labeling in MS, Hemisfair Ballroom, level ThOHam: Ion Mobility: Structure, Hemisfair Ballroom, level 0:0 am - :0 pm Poster Session and Exhibits, Thursday Posters, Poster/Exhibit Hall Odd-number posters present 0:0 am - :00 pm. Even-number posters present :00 - :0 pm. :0-4:0 pm Oral Sessions ThOApm: Food Safety and Chemistry: Non-targeted Screening, Hall, level ThOBpm: Fundamentals: Ion Activation and Dissociation, Room, level ThOCpm: MS Solutions for Drug Metabolism Challenges, Stars Ballroom, level ThODpm: Ambient Ionization: Instrumentation & Applications, Stars Ballroom -, level ThOEpm: Biomarkers: Quantitative Analysis, Stars Ballroom 4, level ThOFpm: Informatics: Peptide and Protein Identification, Hemisfair Ballroom, level ThOGpm: Lipidomics: New MS Technologies and Applications, Hemisfair Ballroom, level ThOHpm: Hydrogen-Deuterium Exchange MS, Hemisfair Ballroom, level 4:45-5:0 pm Plenary Lecture, Hall, level More than the Sum of its Parts: Collective Phenomena in Living Systems, from Single Molecules to Flocks of Birds William Bialek Princeton University 6:0-9:00 pm Closing Event Briscoe Western Art Museum. Ticket required PAGE 4 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

25 SUNDAY EVENING AND MONDAY MORNING ORAL SESSONS SUNDAY EVENING, 4:00-9:00 PM 4:00 4:45 PM, SUNDAY Attention First-time Graduate Students and Undergrads Plan your Strategy: What to See and Do at ASMS Elaine Marluff and JC Poutsma, presiding Stars Ballroom, level 5:00 6:0 PM, SUNDAY TUTORIAL SESSION Vicki Wysocki (The Ohio State University) presiding Hall, level 5:00 5:45 pm Forensic Mass Spectrometry #TellMeSomethingIDontKnow Facundo Fernandez Georgia Institute of Technology 5:45 6:0 pm An Analyte s Journey from Solution into the Gas Phase Lars Konermann University of Western Ontario 6:45 7:45 PM, SUNDAY CONFERENCE OPENING Vicki Wysocki (The Ohio State University) presiding Hall, level Welcome, Vicki H. Wysocki (The Ohio State University) ASMS Vice President for Programs A Molecular Arsenal Against Ebola Virus Erica Ollmann Saphire The Scripps Institute-La Jolla Glen Jackson West Virginia University 7:45 9:00 PM, SUNDAY WELCOME RECEPTION Poster/Exhibit Hall Conference name badge is required. MONDAY MORNING ORAL SESSIONS 8:0-0:0 am Monday Synthetic Polymers Paul Kowalski (Bruker Daltonics, Inc.) Hall, level MOA am 08:0 Mechanistic Studies of Hafnocene Catalyzed Olefin Polymerization; Anthony Paul Gies ; Roger Kuhlman ; Cristiano Zuccaccia ; Alceo Macchioni ; Dow Chemical Company, Freeport, TX; Univation Technologies, Freeport, TX; Dipartimento di Chimica, Biologia e Biotecnologie and CIRCC, University of Perugia, Perugia, Italy MOA am 08:50 Analytical Characterization of PEG and PEG conjugates by Mass Spectrometry; Guanghui Han ; Wilson Phung ; Whitney Shatz ; Julie Q. Hang ; Justin Scheer ; Paul Schnier ; Wendy Sandoval ; Genentech Inc, South San Francisco, CA MOA am 09:0 The Use of Iodo-functionalized Polydisperse Polymers as Mass-defect Tuned Calibrants; Joseph A. Giesen ; Jennifer L. Marple ; Scott M. Grayson ; Tulane University, New Orleans, LA MOA am 09:0 Sequence and Conformational Analysis of Recombinant Polypeptide-Polymer Conjugates; Sahar Sallam ; Bradford A Paik ; Xinqiao Jia ; Chrys Wesdemiotis ; The University of Akron, Akron, OH; University of Delaware, Newark, DE MOA am 09:50 Using MS/MS to Design Information-Encoded Synthetic Copolymers; Laurence Charles ; Jean- François Lutz ; Aix-Marseille University, Marseille MOA am 0:0 Cedex 0, PACA; Institut Charles Sadron, Strasbourg, France Peptoid Fragmentation -The Bias toward Y-Ion Formation; Jianhua Ren ; Yuan Tian ; Ekram Hossain ; Michael Connolly ; Ronald Zuckermann ; University of the Pacific, Stockton, CA; University of the Pacific, Stockton, CA; Lawrence Berkeley National Laboratory, Berkeley, CA 8:0-0:0 am Monday Fundamentals: Ion-Ion and Ion-Neutral Interactions John E. P. Syka (Thermo Fisher Scientific) Room, level MOB am 08:0 Preparation of a Dianion with the Highest Known Proton Affinity: Ortho-Diethynyl Benzene; Berwyck Poad ; Nicholas Reed ; Christopher Hansen ; Adam Trevitt ; Stephen J Blanksby ; Emily Mackay ; Michael Sherburn ; Bun Chan 4 ; Leo Radom 4 ; Queensland University of Technology, Brisbane, Australia; University of Wollongong, Wollongong, Australia; Australian National University, Canberra, Australia; 4 The University of Sydney, Sydney, Australia MOB am 08:50 Evaluating Gas-Phase Folding of Protein Ions Using Cation to Anion Proton Transfer; Kenneth J. Laszlo ; Eleanor B. Munger ; Stephanie C. Heard ; Matthew F Bush ; University of Washington, Seattle, WA; Kalamazoo College, Kalamazoo, MI 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

26 MONDAY GENERAL MORNING INFORMATION ORAL SESSIONS MOB am 09:0 MOB am 09:0 MOB am 09:50 MOB am 0:0 Selective Oxidation via Ion/Ion Reactions: Characteristic Chemistries for Methionine Residues and Cysteine Post-Translational Modifications; Alice Pilo ; Scott A McLuckey ; Purdue University, West Lafayette, IN Identification of Carboxylic Acids in Protonated Drug Metabolites by using Ion-molecule Reactions in a Linear Quadrupole Ion Trap Mass Spectrometer; Joann Max ; Xin Ma ; Rashmi Kumar ; Hilkka I Kenttamaa ; Purdue University, West Lafayatte, IN; Purdue University-Department of Chemistry, West Lafayette, IN;, West Lafayette, IN Ultraviolet Photodissociation of Native Proteins Following Proton Transfer Reaction in an Orbitrap Elite Mass Spectrometer; Dustin D Holden; Jennifer Brodbelt ; The University of Texas, Austin, TX High-throughput Proteomics with Negative Electron Transfer Dissociation (NETD); Nicholas Riley ; Michael S Westphall ; Joshua J Coon ; University of Wisconsin-Madison, Madison, WI 8:0-0:0 am Monday Ion Mobility: Small Molecules, Pharmaceuticals, and DMPK Cris Lapthorn (University of Greenwich) Stars Ballroom, level MOC am 08:0 Highly Accurate Collision Cross Section Measurements for Comprehensive High Throughput Applications; John Fjeldsted ; Ruwan T Kurulugama ; Alex Mordehai ; Emma E Rennie ; Ed Darland ; George C Stafford ; Jody May ; Sarah M Stow ; John A McLean ; Tim Causon ; Teresa Mairinger ; Stephan Hann ; Erin Baker 4 ; Agilent Technologies, Santa Clara, CA; Vanderbilt University, Nashville, TN; Universität für Bodenkultur, Vienna, Austria; 4 Pacific Northwest National Lab, Richland, WA MOC am 08:50 Stereoisomer Separation by Ion Mobility Mass Spectrometry of Multivalent Cation-Chiral Small Molecule Complexes; Christopher Chouinard ; Robin HJ Kemperman ; Nicholas M Oranzi ; Harrison M King ; Richard A Yost ; University of Florida, Gainesville, FL MOC am 09:0 High-throughput Screening Strategy for Tracking Synthetic Biology Variants Libraries using Robotic Platforms and Colormetric Assays Combined with Fast LC-IM MS; Cunyu Yan ; Mark Dunstan ; Nicholas Rattray ; Perdita Barran ; University of Manchester, Manchester, Manchester; University of Manchester, Manchester, UK MOC am 09:0 Amino Acid Separation using Different Drift Gases in an RF-Confining Drift Cell; Kimberly Davidson ; Matthew F Bush ; University of Washington, Seattle, WA MOC am 09:50 Structural Characterization of Monomers and Oligomers of D-Amino Acid Containing Peptides using Linear and Nonlinear Ion Mobility Separations; Xueqin Pang ; Chenxi Jia ; Matthew Baird ; Zhengwei Chen ; Alexandre A Shvartsburg ; Lingjun Li, ; School of Pharmacy, University of Wisconsin Madison, WI; Wichita State University, Wichita, KS; Department of Chemistry, UW- Madison, WI MOC am 0:0 Preparative Ion Mobility Spectrometry using an Inline Periodic Focusing Differential Mobility Analyzer (PFDMA); Kent Gillig ; Chung-Hsuan Chen ; Academia Sinica, Taipei, Nankang, Section, Taipei 5; Academia Sinica, Genomics Research Center Taipei, Taiwan 8:0-0:0 am Monday Instrumentation: FTMS Hilkka Kenttamaa (Purdue University) Stars Ballroom -, level MOD am 08:0 New Gated Approach for Coupling Trapped Ion Mobility Spectrometry to Fourier Transform Ion Cyclotron Mass Spectrometry; Mark Ridgeway ; William Danielson ; Jeremy Wolf ; Melvin Park ; Bruker Daltonic, Billerica, MA; Danielson Software Consulting, Richland, WA MOD am 08:50 Multi-CRAFTI: Simultaneous Measurement of Relative Collision Cross Sections for Multiple Ions Measured using Fourier Transform Ion Cyclotron Resonance Linewidths; David V. Dearden ; Anupriya Anupriya ; Brigham Young University, Provo, UT MOD am 09:0 Tesla FT-ICR Mass Spectrometer for Ultrahigh Resolution Analysis of Complex Mixtures; Donald F. Smith ; David C. Podgorski, ; Yuri E Corilo, ; Christopher L. Hendrickson ; National High Magnetic Field Laboratory, Tallahassee, FL; Future Fuels Institute, FSU Tallahassee, FL MOD am 09:0 Surface Induced Dissociation (SID) of Protein Complexes in a Hybrid FT-ICR; Jing Yan ; Mowei Zhou ; Gilbert Joshua ; Jeremy J. Wolff ; Randall E. Pedder 4 ; Arpad Somogyi 5 ; Royston S. Quintyn ; Lindsay Morrison ; Michael L. Easterling ; Ljiljana Pasa-Tolic ; Vicki H. Wysocki ; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH; Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA; Bruker Corporation, Billerica, MA; 4 Ardara Technologies L.P., Ardara, PA; 5 OSU Mass Spectrometry & Proteomics Facility, The MOD am 09:50 MOD am 0:0 Ohio State University, Columbus, OH Construction of a Dual-Detector Fourier Transform Electrostatic Linear Ion Trap Utilizing In-Trap Potential Lift; Eric Dziekonski ; Robert Santini ; Scott A McLuckey ; Purdue University, West Lafayette, IN Influence of Ion Clouds Micromotion on FTICR Mass-Spectrometer Performances in Ultrahigh Resolution Mode of Operation; Eugene Nikolaev ; Gleb Vladimirov, ; Goekhan Baykut ; Roland Jertz ; Institute for Energy Problems of Chemical Physics, Moscow, Russia; Skolkovo Institute of Technology, Moscow, Russia; Bruker Daltonic GmbH, Bremen, Germany 8:0-0:0 am Monday Diagnostic Clinical Chemistry Heather C. Kuiper (CDC) Stars Ballroom 4, level MOE am 08:0 Intraoperative Diagnosis of Gliomas using Desorption Electrospray Ionization Mass Spectrometry: A Review of Clinical Cases; Valentina Pirro ; Alan K. Jarmusch ; Zane R. Baird ; Clint Alfaro ; Eyas Hattab ; Aaron Cohen- Gadol ; Graham R Cooks ; Purdue University, West Lafayette, Indiana; Purdue University, West Lafayette, IN; Indiana University School of Medicine, Indianapolis, IN MOE am 08:50 DESI-MSI-based Diagnostics of Cirrhotic Liver Diseases; Anna Mroz ; Francesca Rosini ; Alex Pechlivanis ; Luisa Doria ; Evaggelia Liaskou ; Gideon Hirschfield ; Simon Taylor-Robinson ; David Jones ; Robert Goldin ; Elaine Holmes ; Zoltan Takats ; Imperial College London, London, United PAGE 6 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

27 MONDAY MORNING ORAL SESSIONS MOE am 09:0 MOE am 09:0 MOE am 09:50 MOE am 0:0 Kingdom; University of Birmingham, Birmingham, UK; Newcastle University, Newcastle upon Tyne, UK On-demand Disease Diagnosis using D Microfluidic Paper-based Analytical Devices Capable of On-chip Mass Spectrometry; Abraham Kwame Badu Tawiah ; Suming Chen ; Deidre E Damon ; Ohio State University, Columbus, OH Clinical Diagnosis of Botulism with Mass Spectrometry; Suzanne R. Kalb ; Dongxia Wang ; Jakub Baudys ; Kaitlin Hoyt ; Kathryn Pigg ; John R Barr ; CDC, Atlanta, GA; Battelle Memorial Institute, Atlanta, GA Typing of Bacterial Strains using Ultrahigh Resolution MALDI-FTICR-MS; Frank Fleurbaaij ; Margriet E.M. Kraakman ; Eric C. J. Claas ; Wilco C. Knetsch ; Hans C. van Leeuwen ; Yuri E.M. van der Burgt ; Karin Ellen Veldkamp ; Wil Goessens ; Bart J. Mertens 4 ; Ed J. Kuijper ; Paul J. Hensbergen ; Simone Nicolardi ; Center for Proteomics and Metabolomics, LUMC, Leiden, NL; Department of Medical Microbiology, LUMC, Leiden, NL; Department of Medical Microbiology and Infectious Disease, Erasmus MC, Rotterdam, NL; 4 Department of Medical Statistics, LUMC, Leiden, NL The Necessity for Liquid Chromatography in Drug of Abuse Analysis for Resolution of Opiate- Derived Interferences; Brian Rappold; Essential Testing, Collinsville, IL 8:0-0:0 am Monday Informatics: Discovery Proteomics Xiaowen Liu (Indiana University) Hemisfair Ballroom, level MOF am 08:0 Enabling Massive Blind Database Search using Multiple Enzyme Proteomics; Laurence E. Bernstein ; Seungjin Na ; Nuno Bandeira,, 4 ; University of California San Diego, San Diego, CA; Center for Computational Mass Spectrometry, University of California San Diego, La Jolla, CA; Computer Science and Engineering, University of California San Diego, La Jolla, CA; 4 Skaggs School of Pharmacy, UC San Diego, La Jolla, CA MOF am 08:50 Embracing Complexity and Diversity: Discovery Metaproteomics of Multiple Microbiomes using the Galaxy Framework; Pratik Jagtap ; Brian Sandri ; Somaieh Afiuni-Zadeh ; Kevin Viken ; Kristin Boylan ; Jim Johnson ; Thomas F McGowan ; Maneesh Bhargava ; Chris Wendt ; Amy Skubitz ; Joel Rudney ; Tim Griffin ; Center for Mass Spectrometry and Proteomics, UMN, St.Paul, MN; University of Minnesota, Minneapolis, MN; University of Minnesota Supercomputing Institute, Minneapolis, MN MOF am 09:0 Maximizing Shotgun Proteomics Isobaric Tagging Data Output using MS/MS Multi- Objective Optimization Algorithm; John Corthésy ; Kostantinos Theofilatos ; Seferina Mavroudis, ; Ornella Cominetti ; Mona Remlawi 4 ; Francesco Ferraro 4 ; Antonio Núñez Galindo ; Ivan Montoliu ; Martin Kussmann ; Spiros Likothanassis,5 ; Loïc Dayon ; Molecular Biomarkers Core, Nestlé Institute of Health Sciences, Lausanne, Switzerland; InSybio Ltd., London, United Kingdom; Department of Social Work, School of Sciences of Health and Care, Technological Educational Institute of Patras, Patras, Greece; 4 Bio System Informatics, Nestlé Institute of Health Sciences, Lausanne, Switzerland; 5 Department of Computer Engineering and Informatics of the University of Patras, Patras, Greece MOF am 09:0 MOF am 09:50 MOF am 0:0 Real-Time Informatics: A Database Search Increases Depth and Accuracy of Isobaric Label Quantitation in Discovery Proteomics; Christopher Michael Rose ; Derek J Bailey ; Joao Paulo ; Jeremy D O Connell ; David P Nusinow ; Joel M Chick ; Steven P Gygi ; Harvard Medical School, Boston, MA; Thermo Fisher Scientific, San Jose, CA An informatic Framework for Defining Multi- Proteoform Complexes (MPCs) by Native Top- Down Mass Spectrometry; Nicole A Haverland ; Owen S Skinner ; Pierre C Havugimana ; Luca Fornelli ; Bryan P Early ; Joseph B Greer ; Ryan T Fellers ; Kenneth R Durbin ; Luis H. F. Do Vale ; Rafael D Melani ; Henrique S Seckler ; Micah Nelp ; Richard D LeDuc ; Vahe Bandarian ; Philip D. Compton ; Neil L Kelleher ; Northwestern University, Evanston, IL; University of Brasilia, Brasilia, Brazil; University of Arizona, Tucson, Arizona TargetSeeker-MS: A Bayesian Inference Approach for Drug Target Discovery using Protein Fractionation Coupled to Mass Spectrometry; Mathieu Lavallée-Adam ; Alexander Pelletier, ; Jolene K. Diedrich, ; William Low ; Michael Petrascheck ; James J. Moresco, ; John R. Yates III, ; The Scripps Research Institute, La Jolla, CA; UCSD, La Jolla, CA; The Salk Institute, La Jolla, CA 8:0-0:0 am Monday Metabolomics: Untargeted Profiling Corey D. Broeckling (Colorado State University) Hemisfair Ballroom, level MOG am 08:0 Automated Solid Phase Extractions Coupled with Ion Mobility-Mass Spectrometry Analyses Allow Rapid Metabolomic Screening of Complex Plasma and Urine Samples; Erin S. Baker ; Xing Zhang ; Xueyun Zheng ; Kristin E. Burnum- Johnson ; Jennifer E Kyle ; Young-Mo Kim ; Erika M. Zink ; Matthew E Monroe ; Yehia M Ibrahim ; Daniel J Orton ; Justin G. Teeguarden ; Thomas O Metz ; Richard D. Smith ; Pacific Northwest National Laboratory, Richland, WA; University of Colorado, Denver, CO MOG am 08:50 Untargeted Profiling with Single-cell MS Uncovers Small-Molecule Cell Heterogeneity along the Left-Right Body Axis in the Frog Embryo; Rosemary Masu Onjiko ; Sydney E Morris ; Sally A Moody ; Peter Nemes ; Department of Chemistry, The George Washington University, Washington, DC; Department of Anatomy & Regenerative Biology, The George Washington University, Washington DC, DC MOG am 09:0 Metabolomics: Elemental Composition from Ultrahigh Resolution FT-ICR MS; Structure from Two-Dimensional H/C NMR Spectroscopy; Alan G. Marshall ; Lidong He ; Lissa C Anderson ; Christopher L Hendrickson ; Cheng Wang 4 ; Lei Bruschweiler Li 4 ; Dawei Li 4 ; Rafael Bruschweiler 4 ; Ion Cyclotron Resonance Prog, Tallahassee, FL; Florida State University, Tallahassee, Florida; National High Magnetic Field Laboratory, Tallahassee, FL; 4 Ohio State University, Columbus, MOG am 09:0 OH High-Throughput Discovery of New Natural Products and Their Biosynthetic Gene Clusters using a Metabologenomics Approach; Anthony Goering ; Ryan A McClure ; James R Doroghazi ; Kou-San Ju ; Jessica C. Albright ; Nicole Haverland ; Yongbo Zhang ; Regan J Thomson ; William W Metcalf ; Neil L Kelleher ; Northwestern University, 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

28 MONDAY GENERAL MORNING INFORMATION ORAL SESSIONS MOG am 09:50 MOG am 0:0 Chicago, IL; Northwestern University, Evanston, IL; University of Illinois at Urbana-Champaign, Urbana- Champaign, IL Untargeted Stable-isotope Tracing of Folatemediated -C Trafficking in Cancer Cells and an in vitro Dmodel of Neural Tube Closure; Qiuying Chen ; Amanda K Vaughn ; John W Steel ; Robert M Cabrera ; Richard H Finnell ; Steven Gross ; Weill Medical College of Cornell, New York, NY; University of Texas at Austin, Austin, TX Integration of Personal Metabolome and other Omes: Application to the Onset of Type Diabetes; Kevin Contrepois ; Michael Snyder ; Stanford University, Stanford, California; Stanford University School of Medicine, Palo Alto CA 8:0-0:0 am Monday Membrane Protein MS Nina Morgner (Johann Wolfgang Goethe-University) Hemisfair Ballroom, level MOH am 08:0 Ion Mobility-Mass Spectrometry Reveals the Stoichiometry and Structures of Lipid Bound Amyloidogenic Peptide Complexes within Nanodiscs; Richard A Kerr ; Jukyung Kang ; Anna Schwendeman ; Brandon T Ruotolo ; University of Michigan, Ann Arbor, MI MOH am 08:50 Surface Induced Dissociation Provides Insight into Membrane Protein-Lipid Interactions; Sophie Harvey, ; Yang Liu ; Wen Liu ; Vicki Wysocki ; Arthur Laganowsky ; The Ohio State University, Columbus, Ohio; University of Manchester, Manchester, United Kingdom; Texas A&M Health Science Center, Houston, Texas MOH am 09:0 Identification and Characterization of Small Membrane Protein Complex Subunits Presenting Challenges for Routine Mass Spectrometric Analysis; Julian Langer ; Anja Resemann ; Martin Kohlstaedt ; Detlev Suckau ; Schara Safarian ; Hartmut Michel ; MPI for Biophysics, Frankfurt Am Main, Germany; Bruker Daltonic GmbH, Bremen, Germany MOH am 09:0 MOH am 09:50 MOH am 0:0 XL-FASP: A New Integrated Cross-Linking Workflow to Study Extra Large Membrane Protein Complexes; Martial Rey ; Eric Durand, ; Eric Cascales ; Rémi Fronzes ; Julia Chamot- Rooke, ; Institut Pasteur, Paris, France; Institut de Microbiologie de la Méditerranée, CNRS, Marseille, France; CNRS, Paris, France Top-down and Middle-down High-Resolution Mass Spectrometry of Lipidated Proteins; Julian Whitelegge ; Joseph Capri ; Whitaker Cohn ; Don Puppione ; Pasqual Liaux ; Frederic Halgand ; University of California, Los Angeles Los Angeles, CA; Ruhr University Bochum, Bochum, Germany; University Paris Sud, Orsay, France Monitoring the Dynamic N-linked Cell Surface Glycoproteome by Quantitative Proteomics; Christian Eberl ; Mathias Kalxdorf ; Stephan Gade ; Marcus Bantscheff ; Cellzome GmbH a GSK company, Heidelberg, Germany 0:0 AM :0 PM, MONDAY MONDAY POSTER SESSION Poster/Exhibit Hall Lunch Concessions are open :00 am - :00 pm Odd-number posters present 0:0 am - :00 pm Even-number posters present :00 - :0 pm :0 am :00 pm Undergraduate Students Meet the Experts at tables reserved for you in Poster/Exhibit Hall. PAGE 8 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

29 MONDAY AFTERNOON ORAL SESSIONS :0-4:0 pm Monday Food Safety and Chemistry: Foodomics, allergens, bacteria, foods Katherine L. Fiedler (U.S. FDA) Hall, level MOA pm 0:0 SWATH vs. MRM for Food Safety -Using Advanced MS to Verify the Gluten-free Status of Barley; Michelle Lisa Colgrave ; Keren Byrne ; Gregory Tanner ; Crispin Howitt ; CSIRO Agriculture, Brisbane, Australia; CSIRO Agriculture, MOA pm 0:50 MOA pm 0:0 MOA pm 0:0 MOA pm 0:50 MOA pm 04:0 Canberra, Australia Analyses of Human Milk Oligosaccharides Discover Factors that Enhance and Diminish Infant Growth; Jasmine C. C. Davis ; Sarah Totten ; Lauren D. Wu ; Sridevi Krishnan ; Mark R. Charbonneau ; Michael J. Barratt ; Jeffrey I. Gordon ; Angela M. Zivkovic ; Carlito B Lebrilla ; University of California, Davis, Davis, CA; Stanford University School of Medicine, Palo Alto CA; Washington University in St. Louis, St. Louis, MO Risk Verses Benefits for Cadmium, Lead and Mercury Exposure From Seafood Consumption; Marc E. Engel; FDACS, Tallahassee, FL Chemical Changes in a Gamma Ray-Irradiated Rodent Diet Revealed by nanolc-ms/ms; Jeevan K Prasain ; Landon Wilson ; Clinton J Grubbs ; Stephen Barnes ; University of Alabama at Birmingham, Birmingham, AL Investigation of Sample Preparation and Data Acquisition Effects on Non-Targeted Screening of Food Matrices Using LC/HR-MS; Ann M Knolhoff ; Caitlin Kneapler ; Timothy R Croley ; FDA/CFSAN, College Park, MD Forensic Analysis of a Mass Poisoning in Mozambique Associated with a Homebrewed Beverage using LC-HRAM MS and DART- MS; Sara Kern ; Travis M. Falconer ; Jennifer L Brzezinski ; Brian L Boyd ; James A Turner ; Jonathan J Litzau ; US FDA, Cincinnati, OH :0-4:0 pm Monday Fundamentals: Ion Spectroscopy Thomas Rizzo (École Polytechnique Fédérale de Lausanne (EPFL)) Room, level MOB pm 0:0 Structural Transitions in Gas Phase Proteins Investigated via IR Spectroscopy: from Native to Helical to Unzipped; Isabel Gonzalez ; Eike Mucha ; Jongcheol Seo ; Waldemar Hoffmann ; Stephan Warnke ; Kevin Pagel, ; Gert Von Helden ; Fritz-Haber-Institut der Max-Planck-Gesellschaft, Berlin, Germany; Freie Universität Berlin, Berlin, Germany MOB pm 0:50 Understanding Structures of Amino Acid Cluster Ions in the Gas Phase: Solved and Unsolved Problems; Xianglei Kong; Nankai University, Tianjin MOB pm 0:0 Conformation-specific IR-UV Double-resonance Spectroscopy and Structural Analysis of Sodiated Leucine Enkephalin; Nicole Burke ; Christopher Harrilal ; Andrew DeBlase ; Timothy Zwier ; Scott A McLuckey ; Purdue University, West Lafayette, IN MOB pm 0:0 Action-Excitation Energy Transfer for the Structural Characterization of Proteins; Nathan Hendricks ; Ryan R Julian ; University of California, Riverside, Riverside, CA; University of California, Riverside Riverside, CA MOB pm 0:50 MOB pm 04:0 Gas-phase VUV Photoionization and Photofragmentation of Geometrically Well- Defined Coinage Metal Nanocluster Cations; Richard A. J. O hair ; Steven Daly ; Athanasios Zavras ; Laurent Nahon 4 ; Jiaye Li 5 ; Alexandre Giuliani 4 ; Rodolphe Antoine ; Philippe Dugourd, 6 ; University of Melbourne, Victoria, Australasia; Université Lyon, Lyon, France; University of Melbourne, Melburne, Australia; 4 SOLEIL, l Orme des Merisiers, St Aubin, Gif sur Yvette Cedex, France; 5 University of Melbourne, Victoria, Australia; 6 CRNS, Lyon, France Near-UV Water Splitting by Gas-Phase Copper(bipy) Complexes; Andy Dang ; Frantisek Turecek ; Christopher J Shaffer ; Victor Ryzhov ; Michael Lesslie ; John Lawler ; University of Washington, Seattle, WA; Valspar, Minneapolis, MN; Northern Illinois University, DeKalb, IL :0-4:0 pm Monday Instrumentation: New Developments in Ionization and Sampling W. Alexander Donald (University of New South Wales) Stars Ballroom, level MOC pm 0:0 Measuring Masses of Single Bacterial Whole Cells with Laser Induced Acoustic Desorption Plasma Charge Detection Quadrupole Ion Trap Mass Spectrometer; Shao-Yu Liang ; Chou-Hsun Han ; Dineshkumar Yograj Turkar ; Avinash Adhikrao Patil ; Szu-Wei Chou, ; Wen-Ping Peng ; National Dong Hwa University, Shoufeng Hualien, Taiwan; AcroMass Technologies, Inc. Taipei, Taiwan MOC pm 0:50 Near Field Ablation High Lateral Resolution Sampling for Mass Spectrometry; Fan Cao ; Fabrizio Donnarumma ; Kermit K Murray ; Louisiana State Univeristy, Baton Rouge, LA MOC pm 0:0 Ultra-Soft Picosecond Laser Extraction of Biological Compounds from Water and Tissue for Mass Spectrometry; Wesley Robertson ; Yinfei Lu ; Cornelius L Pieterse ; Frederik Busse ; R.J.Dwayne Miller ; Max Planck Institute for the Structure and Dynamics of Matter, Hamburg, Germany MOC pm 0:0 Automated High Throughput Identification of Microorganisms using Rapid Evaporative Ionisation Time of Flight Mass Spectrometry (REIMS-ToF-MS); Zsolt Bodai ; Daniel Simon ; Schaffer Richard ; Frankie Bolt ; Tamas Karancsi ; Julia Balog ; Tony Rickards ; Adam Burke ; Simon Cameron ; Kate Hardiman ; Monica Rebec ; Zoltan Takats ; Imperial College, London, United Kingdom; Waters Research Center, Budapest, Hungary MOC pm 0:50 A Robotic Trapping Column Exchanger for Increasing Clinical Assay Throughput by Capillary Liquid Chromatography-Mass Spectrometry; Sandra E. Spencer ; Huilin Shi ; Thomas N. Corso ; Michael J MacCoss ; Univ. of North Carolina at Chapel Hill, Chapel Hill, NC; University of Washington, Seattle, WA; CorSolutions, LLC., Ithaca, NY MOC pm 04:0 Open Probe Fast GC-MS Combining Ambient Sampling, Ultra-Fast Separation and In-Vacuum Ionization for Real Time Forensic Analysis; Uri Keshet ; Aviv Amirav ; Alexander B Fialkov ; Tal Alon ; Tel Aviv University, Tel Aviv, Israel; Tel-Aviv University, Tel-Aviv, Israel 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9

30 MONDAY GENERAL AFTERNOON INFORMATION ORAL SESSIONS :0-4:0 pm Monday Antibodies and Antibody Drug Conjugates Shawna Hengel (Seattle Genetics, Inc.) Stars Ballroom -, level MOD pm 0:0 Leveraging Antibody Structure Analysis via Data Multiplexing in Top-Down Targeted Protein analysis; Kristina Srzentic ; Konstantin Nagornov ; Anton N Kozhinov ; Yury O Tsybin ; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Spectroswiss Sàrl, Lausanne, Switzerland MOD pm 0:50 Extending the Middle-Down HDX-MS Method for Residue-Level Structural Characterization of Antibody-Antigen Complexes; Jingxi Pan ; Suping Zhang ; Christoph H. Borchers, ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; MRM Proteomics, Inc., Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada MOD pm 0:0 MOD pm 0:0 MOD pm 0:50 MOD pm 04:0 A Modular and Adaptive Mass Spectrometry- Based Platform for Support of Bioprocess Development toward Optimal Host Cell Protein clearance; Feng Yang ; Donald E. Walker ; Joseph Carver ; David A. Michels ; Christopher Yu ; Genentech Inc, South San Francisco, CA Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of Released Linker-Payload from Antibody-Drug- Conjugate with Maleimide-Linker in Plasma; Cong Wei ; Guodong Zhang ; Tracey Clark ; Frank Barletta ; Nathan Tumey ; Brian Rago ; Steven Hansel ; Xiaogang Han ; Pfizer, Groton, CT; Shire, Lexington, MA Profiling Multiple Post-translational Modifications of Therapeutic Antibodies Circulating in Human Patients; Yinyin Li ; Michael Monine ; Yu Huang ; Patrick Swann ; Yelena Lyubarskaya ; Biogen Inc., Cambridge, MA Model-Based Algorithms for Intact Mass Analysis of Biotherapeutics; Marshall W. Bern ; Yong J Kil ; Eric Carlson ; Doron Kletter ; Wilfred Tang ; Christopher Becker ; Protein Metrics, Palo Alto, CA; Protein Metrics, San Carlos, CA :0-4:0 pm Monday Data Independent Acquisition: Innovative Methods and Applications Andrew K. Ottens (Virginia Commonwealth University) Stars Ballroom -4, level MOE pm 0:0 LC SWATH-MS/MS Data Acquisition with Deconvolution of High-Resolution MS Data in Metabolomics; Tomas Cajka ; Oliver Fiehn ; UC Davis Genome Center, Davis, CA MOE pm 0:50 A Promising Alternative to SWATH:MS- based Strategy(IonStar) Enables In-Depth and Reproducible Proteomics Quantification in Large Cohorts with High Accuracy and Extremely-Low- Level-Missing-Data; Xiaomeng Shen, ; Jun LI ; Shichen Shen, ; Qiang Hu 4 ; Xin Miao ; Chengjian Tu, ; Lei Nie 5 ; Xue WANG 4 ; Jianmin Wang 4 ; William J Jusko ; Benjamin C Orsburn 6 ; Jun Qu, ; Dept. of Biochemistry at SUNY at Buffalo, Buffalo, NY; Center of Excellence in Bioinformatics&Life Sci., Buffalo, NY; Dept. of Pharmaceutical Sci. at SUNY at Buffalo, Buffalo, NY; 4 Rosewell Park Cancer Institute, Buffalo, NY; 5 Shandong University, Jinan, Shandong; 6 Thermo Fisher Scientific, San Jose, CA MOE pm 0:0 MOE pm 0:0 MOE pm 0:50 MOE pm 04:0 Qualitative and Quantitative Characterization of a Novel DIA Method for Omics Analysis and its Application to Biomedical Analyses; Arthur Moseley ; Chris Hughes ; Erik J. Soderblom ; Keith Richardson ; Will Thompson 4 ; Jason Wildgoose ; James Langridge ; Duke University School of Medicine, Durham, NC; Waters, Wilmslow, United Kingdom; Duke University School of Medicine, Durham, NC; 4 Duke University School of Medicine, Durham, NC Bidimensional FT-ICR MS: a fully Data Independent Acquisition; Fabrice Bray ; Lionel Chiron ; Matthias Witt ; Marc-André Delsuc 4 ; Christian Rolando 5 ; Univ. de Lille, Sciences et Technologies, Villeneuve d Ascq, France; CASC4DE, Strasbourg, France; Bruker Daltonic GmbH, Bremen, Germany; 4 Université de Strasbourg, Strasbourg, France; 5 Univ. de Lille, Sciences et Technologies, Villeneuve d Ascq Data Independent Acquisition for the Rapid Screening of de novo Protein Designs; Jason Michael Gilmore ; Jorge Fallas ; George Ueda ; David Baker ; Michael J MacCoss ; University of Washington, Seattle, WA High Content Discovery Proteomics of a Breast Tumor Tissue Microarray using Data Independent Acquisition; Bin Fang ; Douglas C Marchion ; Amol Prakash ; Scott M Peterman ; Michelle Fournier ; Zena Sayegh ; Joseph J Johnson ; Agnieszka Kasprzak ; Daryoush Saeed-Vafa ; Roohi Ismail-Khan ; Steven A Eschrich ; Anthony M Magliocco ; John Koomen 4 ; Moffitt Cancer Center, Tampa, FL; Optys Tech Corporation, Philadelphia, PA; Thermo Fisher, San Jose, CA; 4 H. Lee Moffitt Cancer Center, Tampa, FL :0-4:0 pm Monday Informatics: Metabolomics Hyung Won Choi (National University of Singapore) Hemisfair Ballroom, level MOF pm 0:0 Collaborative Human Computing: The Next Generation Paradigm in Metabolomics; Mingxun Wang, ; Pieter Dorrestein ; Nuno Bandeira,, ; Center for Computational Mass Spectrometry, University of California San Diego, La Jolla, CA; Computer Science and Engineering, University of California San Diego, La Jolla, CA; Skaggs School of Pharmacy, UC San Diego La Jolla, CA MOF pm 0:50 FDR-controlled Metabolite Annotation for High- Resolution Imaging Mass Spectrometry; Andrew Palmer ; Michael Becker ; Ilya Chernyavsky ; Dominik Fay ; Artem Tarasov ; Vitaly Kovalev ; Jens Fuchser ; Sergey Nikolenko ; Theodore Alexandrov, 4, 5 ; European Molecular Biology Laboratory, Heidelberg, Germany; Bruker Daltonic GmbH, Bremen, Germany; University of Bremen, Bremen, Germany; 4 Skaggs School of Pharmacy, UC San Diego La Jolla, CA; 5 SCiLS GmbH, Bremen, Germany MOF pm 0:0 Tandem Mass Spectral Libraries of Recurrent Unidentified Spectra for Urine and Plasma: A New Kind of Library for Metabolomics Applications; Yamil Simon ; Ramesh Marupaka ; Xinjian Yan ; Yuri Mirokhin ; Kelly H. Telu ; William E Wallace ; Stephen E Stein ; NIST, Gaithersburg, MD; NIST, Gaithersburg MD MOF pm 0:0 Hydrogen Rearrangement Rules for Computational MS/MS Fragmentation; Hiroshi Tsugawa ; Wataru Tanaka ; Ryo Nakabayashi ; PAGE 0 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

31 MONDAY AFTERNOON ORAL SESSIONS MOF pm 0:50 MOF pm 04:0 Kazuki Saito, ; Masanori Arita, 4 ; RIKEN Center for Sustainable Resource Science, Yokohama, Japan; SOKENDAI, Mishima, Japan; Chiba University, Inage-ku, Japan; 4 National Institute of Genetics, Mishima, Japan New in BioCyc: Pathway Collages and Pathway Prediction Algorithm; Peter Karp; SRI International, Menlo Park, CA Normalization and Integration of Large-Scale Mass Spectrometry-based Metabolomics Data Using Support Vector Regression; Xiaotao Shen ; Zhengjiang Zhu ; IRCBC, Chinese Academy of Sciences, Shanghai, China :0-4:0 pm Monday Nucleic Acid MS Silvia Balbo (University of Minnesota) Hemisfair Ballroom, level MOG pm 0:0 RNA Modification Mapping from Multiple Bacteria in a Single Sample using LC-MS/ MS; Xiaoyu Cao ; Patrick A Limbach ; University of Cincinnati, Cincinnati, Ohio; University of Cincinnati, Cincinnati, OH MOG pm 0:50 Exploring the Use of Top-Down Mass Spectrometry for the Identification, Localization, and Relative Quantitation of RNA Nucleobase Methylations; Heidelinde Glasner ; Christian Riml ; Christoph Falschlunger ; Ronald Micura ; Kathrin Breuker ;, Innsbruck, Tyrol; University of Innsbruck, Innsbruck, Austria MOG pm 0:0 Cation Binding to Nucleic Acids; Adrien Marchand ; Clémence Rabin ; Sandrine Livet ; Solenne Delahaye ; Valentina D Atri ; Josephine Abi-Ghanem ; Frédéric Rosu ; Valerie Gabelica ; Univ. Bordeaux / Inserm / CNRS (ARNA Laboratory), IECB Pessac, France; CNRS UMS 0, IECB Pessac, France MOG pm 0:0 Plasticity in Cancer Nucleotide Metabolism Revealed by Multiplexed MRM Assays; Thuc Le ; Soumya Poddar ; Joseph Capri ; Evan Abt ; Woosuk Kim ; Julian P Whitelegge ; Kym F Faull ; Caius Radu ; UCLA, Los Angeles, CA MOG pm 0:50 MOG pm 04:0 Identification and Characterizations of 8,5 -cyclo- -deoxypurine Lesion-binding Proteins; Preston Williams ; Pengcheng Wang ; Yinsheng Wang ; University of California - Riverside, Riverside, CA Multi-Class Carcinogenic DNA Adduct Quantification in Formalin-Fixed Paraffin- Embedded Tissues by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry; Jingshu Guo ; Byeong Hwa Yun ; Pramod Upadhyaya ; Lihua Yao ; Sesha Krishnamachari ; Thomas A. Rosenquist ; Arthur P. Grollman ; Robert J. Turesky ; University of Minnesota, Minneapolis, MN; Stony Brook University, Stony Brook, NY MOH pm 0:50 MOH pm 0:0 MOH pm 0:0 MOH pm 0:50 MOH pm 04:0 Germany Developing a New Quantitative Cross-linking Mass Spectrometry (XL-MS) Strategy to Define in vivo Structural Dynamics of Protein Complexes; Clinton Yu ; Xiaorong Wang ; Rosa I Viner ; Alex Huszagh ; Eric Novitsky ; Tonya Second ; Scott Rychnovsky ; Lan Huang ; University of California, Irvine, Irvine, CA; Thermo Fisher Scientific, San Jose, CA Solving the Tertiary Structure of SalBIII Protein by Chemical Cross-Linking/Mass Spectrometry and Molecular Modeling; Allan Jhonathan Ramos Ferrari ; Hugo Cesar de Jesus ; Marcio Vinicius Bertacine Dias ; Luciana Gonzaga de Oliveira ; Peter Leadlay ; Fabio Cesar Gozzo ; University of Campinas, Campinas, Brazil; University of São Paulo, São Paulo, SP; University of Cambridge, Cambridge, UK Combining Zero-Length Cross-Linking and Label-free Proteomics to Identify Functional Binding Residues in an Ordered-Disordered Heterodimeric Protein Complex; Michelle Dubuke ; Stephanie Maniatis ; Mary Munson ; Scott A Shaffer ; UMass Medical School Department of Biochemistry and Molecular Pharmacology, Worcester, MA Charting the Cellular Interactome by Proteome- Wide Cross-Linking Mass Spectrometry; Fan Liu ; Phlip Lossl ; Richard Scheltema ; Rosa Viner ; Albert Heck ; Utrecht University, Utrecht, The Netherlands; Thermo Fisher Scientific, San Jose, CA Global XL-MS: Proteome-scale Interactomes Unifying Cross-Linked Datasets; Devin Schweppe ; Chunxiang Zheng ; Juan Chavez ; Arti Navare ; Xia Wu ; Jimmy K Eng ; James Bruce ; University of Washington, Seattle, WA 4:45-5:0 PM, MONDAY AFTERNOON AWARD LECTURE Jenny Brodbelt (University of Texas, Austin) presiding Hall, level Award for a Distinguished Contribution in Mass Spectrometry Scott A. McLuckey Purdue University :0-4:0 pm Monday Covalent Labeling and Chemical Crosslinking Juri Rappsilber (University of Edinburgh and TU Berlin) Hemisfair Ballroom, level MOH pm 0:0 Crosslink-assisted Structure Determination of the Human Spliceosomal Subcomplex, U4/U6.U5 tri-snrnp; Olexandr Dybkov ; Romina V. Hofele, ; Dmitry E. Agafonov ; Berthold Kastner ; Wen-Ti Liu ; Holger Stark, ; Reinhard Luehrmann ; Henning Urlaub, ; Max Planck Institute for Biophysical Chemistry, Goettingen, Germany; University Medical Center (UMG), Goettingen, Germany; Georg-August-Universitaet Goettingen, Goettingen, 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

32 5:45-7:00 GENERAL PM MONDAY INFORMATION WORKSHOPS There are light refreshments in common areas. 0 Top-Down Proteomics: Ready for Primetime? Ying Ge and Paul Thomas presiding Room 0, level Top Down protein mass spectrometry allows comprehensive analysis of intact, multiply modified proteoforms from complex mixtures. In this workshop, we will provide an update from the Consortium for Top Down Proteomics, discussing new community-wide pilot projects. We will also review and discuss common roadblocks to successful top down proteomics experiments from sample preparation to data acquisition to data analysis in a panel format. A limited number of 5 minute lightning talks will be available for researchers to provide rapid-fire updates on recent achievements and accomplishments of note. Contact workshop chairs if you are interested in presenting. 0 Next Generation LC-MS: Critical Insights & Future Perspectives Hongying Gao presiding Room, level Recent advancement in high resolution mass spectrometry has expanded the capabilities of the instrumentation for both qualitative and quantitative analysis. Coupling UPLC with HRMS, samples can be analyzed without authentic standards nor the knowledge of the analytes in the samples, and data can be banked for post-acquisition data processing when the knowledge of the analytes or the authentic standards becomes available. The ideal super LC/MS technology needs to capture the quantitative and qualitative information of the unknown analytes with a variety of physiological properties in a wide range of chemical space. This data banking approach presents new challenges and opportunities for high resolution LC/MS system. In this workshop, a case in industry will be presented to illustrate the need for advancement in LC and mass spectrometry, and then the latest technology advances in high resolution LC/MS and ion mobility will be presented, followed by open discussions on the capabilities and feasibility of the features of next generation LC/MS. Introduction and Objectives of the Session. Why We Need Super LC/ MS System? Hongying Gao, Pfizer Inc. Challenges and Opportunities in High Resolution LC/MS. Alexander Makarov, Thermo Fisher Scientific. How the Rise of IMS Will Change the Use of LC/MS. Richard (Dick) D. Smith, Pacific Northwest National Laboratory. 0 Art and Cultural Heritage Mass Spec Applications Mehdi Moini presiding Room 5A, level The purpose of this workshop is to discuss the application of MS to art and cultural heritage objects, as well as natural history specimens. This will be an interactive workshop in which various subjects relevant to museums specimens will be discussed in a casual, dialog format. A preliminary list of topics include: ) Analysis of paint, coating and binders; textiles; bone and tissue; ink and paper. ) Mechanism of aging and degradation of art and natural history objects. ) Dating. 4) Impact of radiation on museums specimens. 5) Fossilomics and ancient DNA. 6) Forensic archeology. 7) Species identification of proteinaceous materials used in work of art and natural history. 8) Identification of forgery. 04 Bioinformatics: Challenges & Opportunities in Proteogenomics (Bioinformatics for MS) Sangtae Kim and Meena Choi presiding Room 5B, level Proteogenomics (integrated proteomics and genomics) has gained lots of popularity in recent years. Traditionally, it was mainly used to improve genome annotation of newly or partially sequenced organisms, but now it is also increasingly applied in cancer studies. In this workshop, we will discuss bioinformatics challenges and opportunitiesin proteogenomics. It will begin with short introductory presentations by researchers who have recently conducted large-scale proteogenomics studies, and be followed by audience driven discussions. 05 Environmental Analysis: Emerging Topics (Environmental Applications Interest Group) Achille Cappiello, Marc E. Engel, and Christopher G. Gill presiding Room 5C, level This workshop will feature three or four members of the environmental mass spectrometry community that will informally present a maximum of five slides to generate discussion within the working group. Topic areas for the workshop this year are centered upon emerging contaminants (targeted and non targeted) as well as new analytical approaches for their characterization and measurement. 06 Metal Cationization in MS/MS of Biomolecules (Metal Ion Coordination Chemistry Interest Group) Alexandre Shvartsburg and Cheng Lin presiding Room 5D, level A viable alternative to the prevailing paradigm of ionizing biomolecules by protonation (or deprotonation) is the addition of other charged moieties. Metal cationization commonly introduces distinct isotopic patterns, major conformational changes, novel electronic properties, and/or new dissociation chemistry (especially in electron activated mechanisms) that present diverse and still sparsely explored analytical opportunities. In tandem mass spectrometry, metalation has been employed to stabilize labile modifications, promote complementary and more informative fragmentation pathways, and facilitate isomer separation. In another aspect, the native structure of many biomolecules that is often desirable to preserve in MS depends on the metal coordination. This workshop will encourage the adoption of metal cationization in biological mass spectrometry and particularly MS/MS applications. 07 Proteomics Informatics for the Trans-Proteomic Pipeline Luis Mendoza and Eric Deutsch presiding Room 0A, level The workshop will begin with a brief overview of the Trans-Proteomic Pipeline (TPP) and its newest features and capabilities. We will then focus on 5 individual topics, fostering a discussion with workshop participants on the current strengths, weaknesses, and future directions for the TPP. The workshop will enable participants to describe challenges in proteomic data analysis and help drive directions in software approaches through needs of the community. The topic leads for discussion are: cross-linking analysis with Kojak, label-free quantitative analysis with StPeter, chimeric spectrum analysis with respect, proteomics informatics using cloud computing infrastructure such as Amazon Web Services, and analysis of SWATH-MS data with SWATHProphet. Each topic will be introduced with a brief summary of features and ideas. Then feedback and discussion by the workshop participants will be promoted. 08 Metabolomics: Emerging Technologies for Continued Innovation (Metabolomics Interest Group) Timothy Garrett and Andrew Patterson presiding Room 0BC, level This workshop will begin with a brief discussion of the most exciting technological advances in the field of metabolomics over the past year. The moderators will highlight - noteworthy metabolomic publications that they feel are particularly impressive achievements and survey the audience for their opinions. Three-four invited scientists with expertise in the technologies highlighted will serve as panelists and answer questions posed by the moderators and attendees. The workshop will close with a discussion among the panelists on their perspectives of emerging trends and the role that these technologies are playing in future development. Advances intended to be highlighted are: (i) advances in chromatographic separation of metabolites and its influence on metabolomics data, (ii) innovative experimental designs, and (iii) new tools for metabolite identification. PAGE 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

33 5:45-7:00 PM MONDAY WORKSHOPS 09 Polymer MS Technology: Advancements and Discussion (Polymeric Materials Interest Group) Stephen Rumbelow and Gyorgy Vas presiding Room 0A, level This workshop will focus on updating the group on recent work and challenges faced in the various fields such as academic, government, and industry. The focus of this group is polymer and material analysis utilizing various mass spectrometric techniques for both characterization and quantitation of oligomeric species. This workshop will explore the various ways that polymers and materials are not only analyzed themselves but also how they interact with other materials such as patients, and different type of products such as packaging and medical devices. 0 MS Analysis of Antibody-Drug Conjugates (Pharmaceuticals Interest Group) Christine Gu and Matthew Schenauer presiding Room 0BC, level Due to the success of pharmaceutical interest group workshops since 0, and continued interest in MS analysis of antibody drug-conjugates (ADCs), we propose a similar workshop for 06. After a short informal presentation, less than ten minutes, the majority of the workshop would include an audience driven discussion with the opportunity to ask questions to a panel of experts. The organizers will have backup questions prepared for the panel to start or prompt the discussion if needed. The short presentation will provide an update on current workflows for ADC MS analysis in the industry for the discovery and development. Potential areas of discussion may include the large range of characterization required for ADCs from initial MAb assessment to bioanalytical assay development, with the focus on Mass Spec method development and optimization. To identify potential panelists, gauge the level of interest of the ASMS community, and tailor the discussion we will send out a survey of open ended questions in April. Protocol Repositories for Proteomics and Metabolomics (Analytical Lab Managers Interest Group) Allis Chien and Brett Phinney presiding Room 0A, level Protocols and SOP s are the lifeblood of any analytical core facility. Although finding detailed protocols has gotten easier over the years (Nature Protocols for example), finding protocols that have been validated, via successful use by numerous people, is still challenging and fraught with failure. Often even following a detailed published protocol can fail and the user is left wondering: What happened? In this workshop we will discuss options for finding and using protocol repositories for mass spectrometry-based analytical core facilities (Proteomics and Metabolomics). Specifically, we will discuss the new protocol repository set up by the Association of Biomolecular Resource Facilities (ABRF) along with several other freely available options. internship, and diversity of career options within the MS field. A panel of representatives from government, industrial (domestic and foreign) and academic organizations, will share their knowledge, experience, and practices on career prospects. 4 System Performance: Tracking through Statistical QC Monitoring (LC/MS & Related Topics Interest Group) Michael Bereman and Brent Dixon presiding Room 05, level Liquid chromatography mass spectrometry systems are recognized as highly sensitive and specific tools for metabolomic and proteomic analyses. Ensuring the integrity of data through a system of controls referred to as quality control standards enables a higher level of confidence in the obtained results. Providing intra-laboratory personnel with quality control charts allows for correction when standards exceed acceptability limits. Control charts may be used in an inter-laboratory manner to compare results across labs. By monitoring performance standards, a higher level of commutability of experimental results may be achieved. The workshop will provide a demonstration of online QC tracking through Skyline; system performance tracking and control charting. The workshop will explore available controls for tryptic digestion to ensure proteolytic cleavage. The content will also include a section related to metabolomic analyses. Integrating quality control and performance standards in the experimental design is not a new concept. However, the intention to monitor these standards over time and across experiments presents an opportunity. A major limitation in the broader analysis of experimental control performance has been aggregation and visualization. Precious samples may be better utilized by identifying a trend and performing a preventive action to avoid a failed assay. The overall aim is to shift to a prospective action driven review rather than a retrospective control review approach. AFTER 8:00 PM CORPORATE HOSPITALITY SUITES GRAND HYATT HOTEL Miniaturization of Ion Traps and Related Devices (Ion Trap Interest Group) Daniel Austin and Zheng Ouyang presiding Room 0BC, level Ion traps constitute a major portion of the effort to produce miniaturized mass spectrometers. In addition, the wealth of new ionization techniques have led to many new devices for introduction, transmission, and detection of ions in the context of portable devices. The workshop will start with short (4-minute) snippets from several groups working in this area. Next, a panel-led discussion will address opportunities, applications, and challenges of portable mass spectrometry. MS Career Options: How to Kick-Start your Career (Young Mass Spectroscopists Interest Group) Kristin Wildsmith and Violet Lee presiding Room 04, level The workshop features an interactive panel discussion on professional development (Bring your questions). Topics will be centered around career planning and management, fundamental training, industrial 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

34 TUESDAY GENERAL MORNING INFORMATION ORAL SESSIONS 8:0-0:0 am Tuesday Energy, Petroleum, and Biofuels: Instrumentation and Method Development Young Jin Lee (Iowa State Unniversity) Hall, level TOA am 08:0 Petroleomic Characterization using an Ion Mobility-Orbitrap Platform; Yehia Ibrahim ; Roza Wojcik ; Spencer A Prost ; Sandilya Garimella ; Randolph Norheim ; Erin Baker ; Noor Aly ; Hans Ketelslegers ; Fabian Grimm 4 ; Ivan Rusyn 4 ; Richard D Smith ; Pacific Northwest National Laboratory, Richland, WA; Pacific Northwest National Laboratory, Richland, WA; Concawe, Brussels, BELGIUM; 4 Texas A&M, College Station, TX TOA am 08:50 Molecular Composition of Petroleum Interfacially Active Species: Implications in Emulsion Science; Ryan P. Rodgers ; Amy C Clingenpeel, ; Winston K Robbins 4 ; Steven Rowland 4 ; Yuri E Corilo, 4 ; David C Podgorski 4 ; Nat l High Magnetic Field Lab, Tallahassee, FL; FSU Department of Chemistry and Biochemistry, Tallahassee, FL; National High Magnetic Field Laboratory, Tallahassee, FL; 4 Future Fuels Institute, FSU Tallahassee, FL TOA am 09:0 Gas-phase Hydride Transfer between Carbocations and Analyte Alkanes Provides a Gentle and Controllable Ionization Method with Minimal Fragmentation; Mingzhe Li ; Chunfen Jin ; Hanyu Zhu ; Mark Romanczyk ; Jyrki Viidanoja ; Hilkka I Kenttamaa ; Purdue University-Department of Chemistry, West Lafayette, IN; Neste Oil, Keilaranta, Finland TOA am 09:0 Selective Analysis of Complex Crude Oil Mixtures using Chemical and Instrumental Methods; Wolfgang Schrader ; Alessandro Vetere ; Xuxiao Wang ; Max-Planck Inst für Kohlenforschung., Mülheim / Ruhr, Germany TOA am 09:50 Gel Permeation Chromatography (GPC) Inductively Coupled Plasma High Resolution Mass Spectrometry (ICP HR MS) Parameters Study in Petroleum Product Analysis; Sara Gutierrez Sama, ; Alain Desprez,, ; Gabriel Krier ; Charles-Philippe Lienemann 4 ; Jérémie Barbier 4 ; Ryszard Lobinski ; Caroline Barrere-Mangote, 5 ; Pierre Giusti, 5 ; Brice Bouyssiere, 5 ; CNRS/UPPA, UMR 554, LCABIE, Pau, France; TOTAL Refining and Chemicals, TRTG Gonfreville l Orcher, France; UL, LCP-AMC, Metz, France; 4 IFPEn, Solaize, France; 5 TOTAL RC - CNRS Joint Laboratory CMC :Complex Matrices Molecular Characterization, -, France TOA am 0:0 Online Photoionization Time-of-Flight Mass Spectrometric Study on the Catalytic Pyrolysis of Bituminous Coal over HUSY and HZSM-5; Yanan Zhu ; Jiuzhong Yang ; Fei Qi ; Yang Pan ; University of Science and Technology of China/ USTC, Hefei, P.R. China; Shanghai Jiao Tong University, Shanghai, China 8:0-0:0 am Tuesday Fundamentals: Metal ion Cationization, Metal-Ligand Interactions and Catalysis Jinhua Ren (University of the Pacific) Room, level TOB am 08:0 Chemi-ionization Thermochemistry of the Lanthanides: Relevance for Atmospheric Release Studies; Peter B. Armentrout ; Maria Demireva ; Cameron Owen ; Richard M Cox ; University of Utah, Salt Lake City, UT; Pacific Northwest National Lab, Richland, WA TOB am 08:50 Supermetallization of Peptides and Proteins; Yury Kostyukevich ; Alexey S Kononikhin, ; Maria Indeykina 4, ; Evgeny Kukaev, 4 ; Igor A Popov 4, 5 ; Eugene Nikolaev,,, 4 ; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation; Moscow Institute of Physics and Technology, Moscow, Russia; Institute for Energy Problems of Chemical Physics, Moscow, Russia; 4 Emanuel Institute of Biochemical Physics, Moscow, Russia; 5 Moscow Institute of Physics and Technology, Dolgoprudny Moscow Oblast, Russia TOB am 09:0 Copper-binding and Redox Activity and of a Series of Alternative Methanobactin Peptides; Laurence Angel ; Yashodharani Vytla ; Manogna Deeconda ; Sravya Challa ; Rajpal Vangala ; Jacob W McCabe ; Department of Chemistry, Texas A&M University-Commerce, Commerce, TX TOB am 09:0 Capture of Reactive Monophosphine Ligated Palladium(0) Intermediates by Mass Spectrometry; Qiuling Zheng ; Yong Liu ; Qinghao Chen ; Meihong Hu ; Roy Helmy ; Edward Sherer ; Christopher Welch ; Hao Chen ; Ohio University, Athens, OH; Merck, Darmstadt, Germany TOB am 09:50 Revisiting Organometallic Chemistry by Ion Mobility; Izabella Czerwinska ; Sophie Rappe ; Carlos Larriba-Andaluz ; Nicolas Smargiasso ; Christopher Kune ; Albert Demonceau ; Johann Far ; Lionel Delaude ; Edwin A De Pauw ; Mass Spectrometry Laboratory, University of Liege, Liege, Belgium; Department of Mechanical Engineering, Indiana University-Purdue University, Indiana; Laboratory of Catalysis, University of Liege, Belgium TOB am 0:0 Testing Nanoscale Homogeneity with Massive Cluster Secondary Ion Mass Spectrometry; Michael J Eller ; Stanislav V Verkhoturov ; Emile A Schweikert ; Texas A&M University, College Station, TX 8:0-0:0 am Tuesday HRMS for Quantitation in Drug Discovery, Development and Beyond Ashley Ruth (FDA/DPA) Stars Ballroom, level TOC am 08:0 Analysis of Host Cell Proteins throughout Biopharmaceutical Purification; Martha Stapels ; Michelle Busch ; Samantha Cooper ; Veena Warikoo ; Kate Zhang ; Sanofi Genzyme, TOC am 08:50 TOC am 09:0 TOC am 09:0 Framingham, MA Exploring the Use of HRMS for Circumventing Complex and Lengthy Sample Pre-Treatment for Absolute Quantification of mabs in Plasma/ Serum Samples; Ulrik Hvid Mistarz, ; Tam T. T. N. Nguyen ; Amaury Herbet ; Narciso Costa ; Didier Boquet ; Christophe Junot ; François Becher ; Kasper Dyrberg Rand ; Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark; CEA Saclay, DSV/iBiTec-S/LEMM, Gif sur Yvette, France Evaluation of Ion Mobility and Targeted QTof Acquisition Modes for the Quantitative Analysis of Peptides; Jayne Kirk ; Mark Wrona ; Kelly Doering ; Russell Mortishire-Smith ; Lisa A Vasicek ; Kevin P Bateman ; Waters Corporation, Wilmslow, UK; Waters Corporation, Milford, MA; Merck & Co., West Point, PA Bioanalysis and in vivo Stability Evaluation of a PEGylated Protein Drug by UHPLC-HRMS using a Disulfide-Containing Surrogate Peptide; Naiyu Zheng ; Jianing Zeng ; Amy Manney ; PAGE 4 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

35 TUESDAY MORNING ORAL SESSIONS TOC am 09:50 TOC am 0:0 Lakenya Williams ; Anne-Françoise Aubry ; Kimberly Voronin ; Adela Buzescu ; Yan J Zhang ; Alban Allentoff ; Carrie Xu ; Hongwu Shen ; William Warner ; Mark E Arnold ; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ High-throughput MALDI TOF Mass Spectrometry for Drug Discovery in the Ubiquitin Pathway; Virginia De Cesare ; Axel Knebel ; Matthias Trost ; MRC PPU, University of Dundee, Dundee, United Kingdom Simultaneous Quantitation and Metabolite Profiling of RG-5, a GalNAc-conjugated Oligonucleotide, and Its Five Metabolites using HRAM LC/MS; Brandon Wilcock ; Kai Liu ; Daniel J. Mauchley ; Min Meng ; Troy Voelker ; Brian P. Schultz ; Tate Owen ; John Grundy ; Covance, Salt Lake City, UT; Regulus Therapeutics Inc., San Diego, CA 8:0-0:0 am Tuesday Imaging: Instrumentation & Method Development Wendell P. Griffith (University of Texas at San Antonio) Stars Ballroom -, level TOD am 08:0 Design and Optimization of a Fully-controlled Stainless Steel Sublimator for Matrix Deposition in MALDI-IMS Experiments; Roberto Fernández ; Jone Garate ; Sergio Lage ; Jose A Fernandez ; University of Basque Country, UPV/EHU Leioa Basque Country, Spain TOD am 08:50 Identification of Bio-Molecules at Sub-Micron Lateral Resolution by TOF-SIMS Parallel Imaging MS/MS; Gregory L FisheR ; Nina Ogrinc Potocnik ; Anne L Bruinen ; John S Hammond ; Ron M.A. Heeren ; Physical Electronics, Chanhassen, MN; Maastricht University, M4I, Maastricht, Netherlands TOD am 09:0 Developing a Gas Cluster Ion Beam (GCIB) for Enhanced Ionization and Reduced Matrix Effects in Secondary Ion Mass Spectrometry (SIMS); Hua Tian ; Andreas Wucher ; Nicholas Winograd ; Pennsylvania State University, University Park, PA; University of Duisburg-Essen, Essen, Germany TOD am 09:0 TOD am 09:50 TOD am 0:0 Ultra-High Spatial Resolution AP-SMALDI Mass Spectrometry Imaging of Lipids; Mario Kompauer ; Sven Heiles ; Bernhard Spengler ; Justus Liebig University, Giessen, Germany Forensic Analysis of Latent Fingermarks by Silver-Assisted LDI Imaging MS on Non- Conductive Surfaces; Nidia Lauzon ; Martin Dufresne ; Alexandre Beaudoin ; Pierre Chaurand ; University of Montreal, Montreal, Canada; University of Montreal, Montreal Qc, Canada; Sûreté du Québec, Montreal Qc, Canada Quantitative Imaging of Gold Nanoparticles in Tissues using inkjet-printed Standards; Sukru Gokhan Elci ; Brian Creran ; Bradley Duncan ; Alyssa L M Marsico ; Vincent M Rotello ; Richard W Vachet ; University of Massachusetts, Amherst, MA 8:0-0:0 am Tuesday Quantitative Proteomics in Systems Biology Stephanie Cologna (University of Illinois, Chicago) Stars Ballroom 4, level TOE am 08:0 Diacylglycerol Metabolism in Regulation of Innate and Adaptive Functions of Dendritic Cells; Ku-Lung Hsu ; Myungsun Shin ; University of Virginia, Charlottesville, VA TOE am 08:50 A Systems Approach to Define the Spatial- Temporal Dynamics of Host Organelles upon TOE am 09:0 TOE am 09:0 TOE am 09:50 TOE am 0:0 Viral Infection; Pierre Jean Beltran ; Rommel Mathias ; Ileana M. CristeA ; Princeton University, Princeton, NJ Analysis of Proteomic Variation in the Human Population: The HipSci ips Cell Project; Dalila Bensaddek ; Alejandro Brenes Murillo ; Helena Kilpinen ; Angela Goncalves ; Mariya Chhatriwala 4 ; Rachel Nelson 5 ; Chris Kirton 5 ; Ludovic Vallier 4 ; Daniel Gaffney ; Oliver Stegle ; Richard Durbin ; Angus Iain Lamond ; University of Dundee, Dundee, UK; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK; 4 Pancreatic Genetics, Wellcome Trust Genome Campus, Cambridge, UK; 5 Cellular Generation & Phenotyping, CGaP, Wellcome Trust Sanger Institute, Cambridge, UK Interrogating Oncogenic B-Raf Signaling through micrornas using Functional Proteomics; Thomas Lee ; Nan Wang, ; Stephane Houel, ; Kasey L. Couts ; Natalie G. Ahn ; University of Colorado, Boulder, Colorado; University of Alberta, Edmonton, Canada; Thermo Fisher Scientific, San Jose, CA Correlation of KRAS Proteoform Expression Profiles to Cancer Phenotypes via Integrated Proteogenomic Analysis of Colorectal Tumors; Ioanna Ntai ; Josiah E Hutton ; Richard D Leduc ; Ryan T Fellers ; Neil L Kelleher ; Northwestern University, Evanston, IL; Vanderbilt University, Nashville, TN Hunting Biomass Degrading Enzymes and Their Active Proteoforms through an Activity- Correlated Quantitative Proteomics Platform; Hongyan Ma ; Delafield Graham Daniel ; Zhe Wang ; Si Wu ; University of Oklahoma, Norman, OK 8:0-0:0 am Tuesday Instrumentation: non-ft based Analyzers Michael Westphall (University of Wisconsin-Madison) Hemisfair Ballroom, level TOF am 08:0 Application of Multi Frequency Waveforms for Ion Isolation and Enhancement with the MOMA Ion Trap Mass Spectrometer; Ryan M Danell ; Andrej Grubisic ; Friso H W Van Amerom ; Veronica T Pinnick 4 ; Xiang Li 4 ; Stephanie Getty 5 ; Ricardo Arevalo 5 ; William Brinckerhoff 5 ; Danell Consulting, Inc., Winterville, NC; Center for Research and Exploration in Space Science and Technology (CRESST), University of Maryland, College Park, MD; Mini-Mass Consulting, Inc., Hyattsville, MD; 4 Center for Research and Exploration in Space Science and Technology (CRESST), University of Maryland, Baltimore County, MD; 5 NASA Goddard Space Flight Center, Greenbelt, MD TOF am 08:50 Second Order Space and Velocity Focusing Time of Flight Mass Spectrometry using an Accelerator Field Free Region; Robert E. Haufler ; Bill Loyd ; AB Sciex, Concord, ON; SCIEX, Concord, ON TOF am 09:0 Ion-Ion Proton Transfer and Parallel Ion Parking for Top-Down Analysis of Complex Protein Mixtures; Scott A Ugrin ; Michelle A English ; Dina L Bai ; John E P Syka ; Jeffrey Shabanowitz ; Donald F Hunt ; University of Virginia, Charlottesville, VA; Thermo Fisher Scientific, San Jose, CA 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

36 TUESDAY GENERAL MORNING INFORMATION ORAL SESSIONS TOF am 09:0 TOF am 09:50 TOF am 0:0 System Architecture for Charge-independent Mass Spectrometry using Nanomechanical Resonators; Shawn Fostner, ; Sergio Dominguez Medina,, 4 ; Marc Sansa Perna, ; Thomas Alava, ; Ann-Kathrin Stark,, 4 ; Ariel Brenac 5, 6 ; Henri Blanc, ; Marc Gely, ; Sébastien Hentz, ; Christophe Masselon,, 4 ; Université Grenoble Alpes, Grenoble, France; CEA, LETI, Grenoble, France; CEA BIG-BGE, Grenoble, France; 4 INSERM U08, Grenoble, France; 5 Université Grenoble Alpes, INAC-SPM, Grenoble, France; 6 CEA, INAC- SPM, Grenoble, France Dual-Polarity Ion Trap Mass Spectrometry: Dynamic Control and Monitoring of Gas-phase Ion-ion Reactions; Muyi He ; Dan Guo ; You Jiang ; Xiong Xingchuang ; Zejian Huang ; Xiang Fang ; Wei Xu ; Beijing Institute of Technology, Beijing, China; National Institute of Metrology, Beijing, China Quadrupole Wideband Isolation Directed by Ion Mobility Drift Separation for Analyzing Complex Protein Digests; Bruce Wang ; Ruwan T Kurulugama ; George Stafford ; John Fjeldsted ; Joseph Roark ; Frank Kuhlmann ; Gregor Overney ; Agilent Technologies, Santa Clara, CA 8:0-0:0 am Tuesday Lipids and Profiling Ginger Milne (Vanderbilt University) Hemisfair Ballroom, level TOG am 08:0 Enhanced Discrimination of Healthy Human Brain Tissue and Glioma using Positive and Negative Polarity Desorption Electrospray Ionization with Data Fusion; Clint Miles Alfaro ; Alan K Jarmusch ; Valentina Pirro ; Eyas M Hattab ; Aaron A Cohen-Gadol ; Graham R Cooks 4 ; Purdue University, Winston-Salem, NC; Purdue University, West Lafayette, IN; Indiana University School of Medicine, Indianapolis, IN; 4 Purdue University, West TOG am 08:50 TOG am 09:0 TOG am 09:0 TOG am 09:50 TOG am 0:0 Lafayatte, IN A Novel Post-column Derivatization Method for Profiling Diolome using LC/MS/MS; Jun Yang ; Debin Wan ; Chang Wang ; Bruce D Hammock ; University of California, Davis, Davis, CA Separation and Characterisation of Human Meibum Lipids by Differential Ion Mobility Mass Spectrometry; Sarah E Hancock ; Peta Snikeris ; Stephen J Blanksby ; Todd W Mitchell ; University of Wollongong, Wollongong, Australia; Queensland University of Technology, Brisbane, Australia Nitrated Fatty Acids: Biomarkers of Inflammation and Regulators of Redox Homeostasis; Stacy Gelhaus Wendell ; Bruce A Freeman ; Franca Golin- Bisello ; Gregory Buchan ; Sonia Salvatore ; Soma Jobbagy ; Kara Hughan ; Mark Gladwin ; University of Pittsburgh, Pittsburgh, PA Structure Elucidation of Omega- Fatty Acid Fish Oil Glycerolipid Dietary Supplements by Supercritical Fluid Chromatography Q-TOF- MS; Sheher Mohsin ; Gene S Hall ; Joe Hedrick ; Agilent Technologies, Schaumburg, IL; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, Piscataway, NJ; Agilent Technologies, Wilmington, DE Characterizing the Natural History of Acute Radiation Syndrome of the Gastrointestinal Tract: Combining High Mass and Spatial Resolution using MALDI-FTICR-MSI; Claire Louise Carter ; Jace W Jones ; Kim Hankey ; Ann M Farese ; Thomas J MacVittie ; Maureen A Kane ; University of Maryland, School of Pharmacy Baltimore, MD; University of Maryland School of Medicine, Baltimore, MD; University of Maryland Baltimore, Baltimore, USA 8:0-0:0 am Tuesday Native MS in Structural Biology Alison E. Ashcroft (University of Leeds) Hemisfair Ballroom, level TOH am 08:0 Accurate Determination of the Carbohydrate Content of Highly Heterogeneous Glycoproteins by Native Mass Spectrometry; Guanbo Wang, ; Albert J. R. Heck, ; Biomolecular Mass Spectrometry and Proteomics, Utrecht University, Utrecht, The Netherlands; Netherlands Proteomics Center, Utrecht, The Netherlands TOH am 08:50 High-Confidence Models of Multiprotein Complexes from Ion Mobility-Mass Spectrometry Datasets: Frontiers in Model Generation and Assessment; Joseph D Eschweiler ; Aaron T. Frank ; Brandon T Ruotolo ; University of Michigan, Ann Arbor, MI TOH am 09:0 Structural Characterization of Missense Mutations using High Resolution Mass Spectrometry: The Parkinson s Related Protein DJ- Case Study; Gili Ben-Nissan ; Almog Chotiner ; Michal Sharon ; Weizmann Institute of Science, Rehovot, Rehovot; Weizmann Institute of TOH am 09:0 TOH am 09:50 TOH am 0:0 Science, Rehovot, Israel Characterization of a Nitrogenase Complex from Azotobacter Vinelandii in Gas Phase using Native Mass Spectrometry And Ion Mobility.; Monika Tokmina-Lukaszewska ; Natasha Pence ; Rhesa Ledbetter ; Stephen Keable ; Sudipta Shaw ; Zhiyong Yang ; John Peters ; Lance Seefeldt ; Brian Bothner ; MSU, Bozeman, MT, Bozeman, MT; Utah State University, Logan, UT Top Down Proteomics and Native Ion Mobility- MS Reveals Phosphorylation-Mediated Effects on NF-kB Conformation and Interactions; Matthias Vonderach ; Manohar Dange ; Claire Eyers ; University of Liverpool, Liverpool, United Kingdom Charge Detection Mass Spectrometry Monitors Virus Assembly from Single Subunit to Complete Capsid; Corinne Lutomski ; Kevin Zhao ; Adam Zlotnick ; Martin F Jarrold ; Indiana University, Bloomington, IN; Indiana University, Bloomington, IN 0:0 AM :0 PM, TUESDAY TUESDAY POSTER SESSION Poster/Exhibit Hall Lunch concessions are open :00 am :00 pm Odd-number posters present 0:0 am - :00 pm Even-number posters present :00 - :0 pm PAGE 6 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

37 TUESDAY AFTERNOON ORAL SESSIONS :0-4:0 pm Tuesday Environmental: New Instrumentation and Approaches Alla Zelenyuk (Pacific Northwest National Laboratory) Hall, level TOA pm 0:0 TOA pm 0:50 TOA pm 0:0 TOA pm 0:0 TOA pm 0:50 TOA pm 04:0 Comparison of Soft Ionisation Techniques for the High Resolution Mass Spectrometry Analysis of Environmental Samples with Complex Matrices; Ivan Kourtchev ; Pak Yiu Paddy Szeto ; Duncan Scott ; Ian P O Connor ; Olalekan Popoola ; Arthur Zielinski ; John C Wenger ; Markus Kalberer ; University of Cambridge, Cambridge, UK; University College Cork, Cork, Ireland Laser Diode Thermal Desorption (LDTD)-MS and Machine Learning: a Novel Approach for Ultra Fast Environmental Analysis; Pier-Luc Plante, ; Prudencio Tossou ; Alexandre Drouin ; Francis Brochu ; François Laviolette ; Mario Marchand ; Jacques Corbeil, ; Université Laval, Québec, Canada; Centre de recherche du CHU de Québec, Québec, QC Measurement of Protonated Ions as Sensitive Indicator for Neutral Polycyclic Aromatic Hydrocarbon Chemistry in Combustion by Time-of-Flight Mass Spectrometry; Yasin Karakaya ; Thomas Bierkandt ; Tina Kasper ; Thermodynamics, University of Duisburg-Essen, Duisburg, Germany Ultrafast Quantitative Analysis of Pesticides in Food and Environmental Matrices by SPME- Transmission Mode and Direct Analysis in Real Time; Emanuela Gionfriddo ; German Augusto Gomez-Rios ; Justen Poole ; Janusz Pawliszyn ; University of Waterloo, Waterloo ON, Canada Multivariate Statistics Applied to MALDI-TOF MS Data of Pollen Samples; Franziska Lauer, ; Stephan Seifert, ; Janina Kneipp, ; Steffen M. Weidner ; Federal Institute f. Material Research and Testing, Berlin, Germany; Humboldt University, Berlin, Germany; Fed.Inst.f.Mat.Research, Berlin, Berlin On the Application of Electrochemistry-Mass Spectrometry to Study the Biotransformation of UV Blockers in the Environment; Pedro A. Segura ; Delphine Canion ; Emmanuel Eysseric ; Université de Sherbrooke, Sherbrooke, QC :0-4:0 pm Tuesday New Developments in Ion Detection Martin F. Jarrold (Indiana University) Room, level TOB pm 0:0 The Dynamics of Superconducting Tunnel Junction Cryodetector Energy Response as it Relates to Ion Structure, Surface Area and Density; Logan D. Plath ; David M Sipe ; Jonathan Feldman ; Chenjie Zeng ; Yuxiang Chen ; Rongchao Jin ; Mark E. Bier ; Carnegie Mellon University, Pittsburgh, PA TOB pm 0:50 A Novel Charge Detection Rectilinear Ion Trap Mass Spectrometer (CD-RIT MS) for Detection of High Mass Proteins; Avinash Adhikrao Patil ; Szu-Wei Chou ; Chen-Wei Lee ; Wen-Ping Peng ; National Dong Hwa University, Shoufeng Hualien, Taiwan TOB pm 0:0 Neutralization Charge Detection Method Facilitating Fast and Sensitive Hetero-Phase Ion Detection; Ko-Keng Chang, ; Yi-Hong Cai ; YI-Sheng Wang ; Genomics Research Center, Academia Sinica Taipei, Taiwan; Chemistry Department, National Taiwan University, Taipei, Taiwan TOB pm 0:0 TOB pm 0:50 TOB pm 04:0 Maximising Ion Detection Efficiency using Cycloidal Transport Of Secondary Electrons In Crossed Electric and Magnetic Fields; Dick Stresau ; Scott Morgan ; Toby Shanley ; ETP Ion Detect, Clyde, Australia A Novel Wide Dynamic Range oa-tof Detection System Based on Dual 0-bit ADCs and FPGA Processing; Martin Green ; Garry Scott ; Stephen Platt ; Peter Spreadbury ; Darrell Williams ; Frank Buckley ; Witold Niklewski ; Stephen Hinde ; Martin Palmer ; John Chipperfield ; Waters, Wilmslow, United Kingdom Multiple Frequency Resonance Methods in Quadrupole Ion Trap Mass Spectrometry: Expanding Capabilities and Improving Performance; Dalton Snyder ; Christopher Pulliam ; Joshua S Wiley ; Jason Duncan ; R Graham Cooks ; Purdue University-Department of Chemistry, West Lafayette, IN; California Institute of Technology, Pasadena, CA; Acuity Brands Lighting Inc, Crawfordsville, IN :0-4:0 pm Tuesday Quantitative Analysis in Drug Discovery and Development Jian Wang (Bristol-Myers Squibb) Stars Ballroom, level TOC pm 0:0 The Potential of Micro Sampling in Regulated Bioanalysis using LC-MSMS; Martijn Hilhorst ; Roderik Prins ; Frank Schalken ; PRA Health Sciences, Assen, Drenthe; PRA Health Sciences, Assen, The Netherlands TOC pm 0:50 Universal LBA/LCMS Workflow for Protein Biotherapeutics PK Analysis in Preclinical Assay; Bruce Aungst ; Caroline Becker ; Xun Wang ; Lei Xiong ; Witold Woroniecki ; Yihan Li ; Suma Ramagiri ; Hua-fen Liu ; Zamas Lam ; QPS, Newark, DE; SCIEX, Redwood City, CA TOC pm 0:0 A Trapping micro-lc/ms for Ultra-sensitive, Robust and High-Throughput Quantification of Biotherapeutics and Biomarkers in Complex Matrices; Bo An ; Ming Zhang ; Yang Qu ; Jun Qu; SUNY at Buffalo, Buffalo, NY TOC pm 0:0 Measuring Drug-Target Engagement in Tissue Biopsies Using Affinity Extraction LC-MS/ MS; Eugene F. Ciccimaro ; Yongxin Zhu ; Dmitry Ostanin ; Suzanne Suchard ; Jamus MacGuire ; Qing Xiao ; Ashok R Dongre ; Petia A Shipkova ; Timothy Olah ; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Princeton, NJ TOC pm 0:50 A Label-free, Mass Spectrometry-based High Throughput Candidate Drug Screening Assay: Application to Smith-Lemli-Opitz Syndrome; Jaqueline A Picache ; Stephanie M Cologna, ; Alfred L Yergey ; Pierre Picard ; Catherine Chen ; Kathryn R Burkert ; Christopher A Wassif ; Wei Zheng ; Forbes D Porter ; National Institutes of Health, Bethesda, MD; University of Illinois at Chicago, Chicago, IL; Phytronix Technologies, Quebec, Canada TOC pm 04:0 Cleavable Antibody Drug Conjugate (ADC) Assay Support Enables ADC ADME and Discovery Programs; Brian Rago ; Fengping Li ; Cong Wei ; Xiaogang Han ; Tracey Clark ; Lindsay King ; Nathan Tumey ; Frank Barletta ; Mauricio Leal ; Steven Hansel ; Pfizer, Groton, CT 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

38 TUESDAY GENERAL AFTERNOON INFORMATION ORAL SESSIONS :0-4:0 pm Tuesday Ion Mobility, FAIMS & DMS: New Developments & Applications George Stafford (Agilent Technologies) Stars Ballroom -, level TOD pm 0:0 Moving beyond Collision Cross Sections: Using Cryogenic Infrared Spectroscopy to Determine the Structures of the Mobility-Selected Neuropeptide CabTRPa (APSGFLGMR-NH); Michael Kamrath ; Matthew Glover ; Marta A. S. Perez ; Ursula Rothlisberger ; David E Clemmer ; Thomas R Rizzo ; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Indiana University Dept. Chemistry, Bloomington, IN TOD pm 0:50 Integration of High-field Asymmetric Waveform Ion Mobility and Ambient Ionization Mass Spectrometry for Biological Tissue Imaging; Clara Feider ; Livia S. Eberlin ; University of Texas at Austin, Austin, Texas; University of Texas at Austin, Austin, TX TOD pm 0:0 A Theoretical and Empirical Approach to Separating Isomer Classes in Uniform Field Ion Mobility; James Dodds ; Jody C May ; John A McLean ; Vanderbilt University, Nashville, TN TOD pm 0:0 Separation and Identification of Isomeric Lipids using a Combination of Differential Mobility Spectrometry and Ozone-induced Dissociation; Stephen J Blanksby ; Berwyck L. J. Poad ; Alan T. Maccarone ; Todd W Mitchell ; Queensland University of Technology, Brisbane, QLD; Queensland University of Technology, Brisbane, Australia; University of Wollongong, Wollongong, Australia TOD pm 0:50 Gas Phase Epitope Mapping - A Mass Spectrometric Method for Accurate, Facile, and Rapid Identification of Specific Antibody-Peptide Reactivities; Yelena Yefremova ; Frimpong-Manso Kwabena Opuni ; Hans-Juergen Thiesen ; Michael O Glocker ; Proteome Center Rostock, Rostock, Germany; Institute of Immunology, Rostock, Germany TOD pm 04:0 Ultrahigh IMS Resolution using Novel Traveling Wave Approaches and Long Serpentine Path Length SLIM Modules; Richard D. Smith ; Liulin Deng ; Ahmed Hamid ; Ian K Webb ; Sandilya V.B. Garimella ; Erin S Baker ; Yehia M Ibrahim ; PNNL, Richland, WA :0-4:0 pm Tuesday Qualitative and Quantitative Analysis of Posttranslational Modifications Amber L. Mosley (Indiana University School of Medicine) Stars Ballroom 4, level TOE pm 0:0 Disease-specific Post-translational Modifications in Cystic Fibrosis; Sandra Pankow ; Casimir Bamberger ; John Yates ; The Scripps Research Institute, La Jolla, CA TOE pm 0:50 PTM omics: What Do We Learn from Surveying Many Modifications Simultaneously in Non- Enriched Proteomes? A Study of Lysine Acylations; Hong Nguyen ; Michael McInerney ; Robert Gunsalus ; Joseph A Loo ; Rachel Ogorzalek Loo ; UCLA, Los Angeles, CA; University of Oklahoma, Norman, OK TOE pm 0:0 Redox Proteomics to Study Cysteine Status in Alzheimer s Disease; Renã A. S. Robinson ; Liqing Gu ; University of Pittsburgh, Pittsburgh, PA TOE pm 0:0 TOE pm 0:50 TOE pm 04:0 The Phosphoproteome of the NCI-60 Cell Line Panel Reveals Markers of Drug Sensitivity; Benjamin Ruprecht ; Chen Meng ; Martin Frejno ; Alexander Hogrebe ; Dominic Helm ; Bernhard Kuster ; TU Muenchen, Freising, Germany; TU Muenchen, Freising, Germany; Oxford University, Oxford, United Kingdom Identification of Histone ADP-Ribosylation Sites using High Resolution Mass Spectrometry; Kelly Karch ; Benjamin A. Garcia ; Ben E. Black ; University of Pennsylvania, Philadelphia, PA Comparative Ubiquitylome Analysis of Major Proteasome Inhibitors; Tanya Rocio Porras- Yakushi ; Michael Sweredoski ; Sonja Hess ; Caltech, Pasadena, CA :0-4:0 pm Tuesday Imaging: Computational Methods and Analysis Theodore Alexandrov (EMBL / UCSD / SCiLS) Hemisfair Ballroom, level TOF pm 0:0 Absorption Mode Processing of MALDI-FT-ICR Imaging Data Improves Mapping of Gram- Negative Bacterial Virulence Factors on-tissue; Alison Scott ; David P A Kilgour ; Robert K Ernst ; David R Goodlett ; University of Maryland, Baltimore, MD; Nottingham Trent University, Nottingham, UK TOF pm 0:50 Deep Autoencoders for Dimensionality Reduction of D Mass Spectrometry Imaging Data-Sets for Tumour Classification and Novel Subtypes Identification; Paolo Inglese ; James McKenzie ; Anna Mróz ; James Kinross ; Elaine Holmes ; Zoltan Takats ; Jeremy K Nicholson ; Robert C Glen, ; Kirill Veselkov ; Imperial College London, South Kensington Campus London, United Kingdom; University of Cambridge, Cambridge, UK TOF pm 0:0 Dimensionality Reduction of MALDI Imaging Datasets using Non-Linear Redundant Wavelet Transform-based Representations; Luis Mancera ; Lyna Sellami ; Jamie Cunliffe ; Luis González ; Omar Belgacem ; Clover Bioanalytical Software, Granada, SPAIN; Shimadzu, Kratos TOF pm 0:0 TOF pm 0:50 TOF pm 04:0 Manchester, United Kingdom Current Status and Applications of the Open Data Format imzml; Nicolas Desbenoit ; Amol Fatangare ; Andreas Roempp ; Bioanalytical Sciences and Food Analysis, University of Bayreuth, Bayreuth, Germany; Bioanalytical Sciences and Food Analysis, University of Bayreuth, Bayreuth Generation of Realistic Synthetic Mass Spectrometry Imaging (MSI) Data for the Validation of Multivariate Analysis Methods; Alexander Dexter, ; Alan Race ; Iain B Styles ; Helen J Cooper ; Josephine Bunch, ; University of Birmingham, Birmingham, UK; National Physical Laboratory, Teddington, United Kingdom; University of Nottingham, Nottingham, UK Characterisation of Molecular Signatures in the Xenograft Microenvironment using Novel Tools to Combine Histopathology and Mass Spectrometry Imaging Data; Jo Cappell ; Gert B Eijkel ; Martha Ingola ; Richard J A Goodwin ; Peter Webborn ; Ron M A Heeren ; M4I Institute - Maastricht University, Maastricht, The Netherlands; AstraZeneca, Cambridge, UK PAGE 8 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

39 TUESDAY AFTERNOON ORAL SESSIONS :0-4:0 pm Tuesday Metabolomics: New Technologies and Applications Nichole Reisdorph (University of Colorado Anschutz Medical Campus) Hemisfair Ballroom, level TOG pm 0:0 Symbiotic Interaction between Legumes and Rhizobia Explored by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation; Sylwia Stopka ; Beverly Agtuca ; Christopher Anderton ; David W Koppenaal ; Ljiljana Pasa-Tolic ; Gary Stacey ; Akos Vertes ; George Washington University, Washington, District of Columbia; University of Missouri, Columbia, MO; Pacific Northwest National Laboratory, Richland, WA TOG pm 0:50 Temporal Analysis of Living Human Bronchial Epithelial Cell Signaling and Drug Transportation using nano-desi MS; Ingela Lanekoff ; Erik Lundin ; Jan-Christer Ulvinge ; Mark Nicholas ; Uppsala University, Uppsala, Sweden; AstraZeneca R&D, Gothenburg, Sweden TOG pm 0:0 Solid Phase Microextraction as a Sample Preparation Tool for Untargeted Analysis of Brain Tissue; Nathaly Reyes-Garces ; Ezel Boyacı ; German Augusto Gomez-Rios ; Barbara Bojko ; Janusz Pawliszyn ; University of Waterloo, Waterloo ON, Canada TOG pm 0:0 TOG pm 0:50 TOG pm 04:0 An Integrated Platform for Quantitative Full-Scan Polar LC/MS Metabolomics Reveals Structured Environmental Stress Response in the Yeast Saccharomyces Cerevisiae; Amy Anne Caudy ; Julia A Hanchard ; Kaitlin U Laverty ; Anton Lunyov ; Olga Zaslaver ; Soumaya Zlitni ; Adam Rosebrock ; University of Toronto, Toronto ON, Canada High-throughput Targeted Metabolomics of CoA Metabolites for Modulation of Antibiotic Influx and Efflux in Gram Negative Bacteria; Christopher M. Rath ; Bret Benton ; Javier De Vicente ; Cindy Li ; Bob Moreau ; Xiaoyu Shen ; Lisha Wang ; Brian Feng ; Novartis Institutes for Biomedical Research, Emeryville, CA - California; Denali Therapeutics, South San Francisco, CA - California Higher-throughput Annotation of Plant Metabolomes using Spectral Matching, Computational Identification Tools and Empirical UHPLC-MS-SPE-NMR; Lloyd W. Sumner, ; Feng Qiu, ; Dennis Fine ; Daniel Wherritt ; Zhentian Lei, ; Aiko Barsch 4 ; University of Missouri, Columbia, MO; The Samuel Roberts Noble Foundation, Ardmore, OK; University of Texas, San Antonio, TX; 4 Bruker Daltonic GmbH, Bremen, Germany :0-4:0 pm Tuesday Protein-Ligand Interactions John S. Klassen (University of Alberta) Hemisfair Ballroom, level TOH pm 0:0 An Integrated HDX-MS-Based Platform Characterizes the Interaction between apoe and a ligand: High-Resolution Kinetics, PLIMSTEX, and SUPREX; Hanliu Wang ; Don L Rempel ; Tridib Mondal ; Carl Frieden ; Michael L Gross ; Center for Biomedical and Bioorganic Mass Spectrometry, Washington University in St. Louis, St. Louis, MO; Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, MO TOH pm 0:50 Ligand-Induced Disorder-to-Order Transitions Characterized by Structural Proteomics; Nicholas I Brodie ; Geoff M Gudavicius ; Christopher J Nelson ; Evgeniy V Petrotchenko ; Christoph TOH pm 0:0 TOH pm 0:0 TOH pm 0:50 TOH pm 04:0 H. Borchers, ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; University of Victoria - Genome BC Proteomics Centre, Victoria, BC Targeted MS-based Approach for Protein Ligand Binding Analysis in Complex Biological Mixtures using a Phenacylbromide Modification Strategy; Lorrain Jin ; Carol H Ball ; Michael C Fitzgerald ; Duke University, Durham, NC; Agilent Technologies, Santa Clara, CA Unveiling the Heterogeneity of an Uncharacterized Manganese Oxidizing Multicopper Oxidase Using High Resolution Native Mass Spectrometry and Surface Induced Dissociation; Mowei Zhou ; Jing Yan ; Christine Romano ; Yang Song ; Jeremy J Wolff 4 ; Joshua Gilbert ; Randall E Pedder 5 ; Bradley Tebo ; Vicki H Wysocki ; Ljiljana Pasa-Tolic ; Pacific Northwest National Laboratory - PNNL, Richland, WA; Ohio State University, Columbus, OH; Oregon Health & Science University, Portland, OR; 4 Bruker Daltonic, Billerica, MA; 5 Ardara Technologies L.P., Ardara, PA Probing KIX:Peptide Allosteric Interactions by Ion Mobility-Mass Spectrometry; Jessica Rabuck- Gibbons ; Jean M Lodge ; Anna K Mapp ; Brandon T Ruotolo ; University of Michigan, Ann Arbor, MI Tetrameric BanLec Neutralises HIV through Bidentate Binding to Specific Viral Glycan Structures; Jonathan Hopper ; Oliver Grant ; Stephen Ambrose ; Stefanie Krumm ; Timothy Allison ; Mark Tully 4 ; Laura Pritchard ; Gabriel Ozorowski 5 ; Andrew Ward 5 ; Max Crispin ; Katie Doores ; Robert J Woods ; Justin Benesch ; Carol V Robinson ; Weston Struwe ; University of Oxford, Oxford, UK; University of Georgia, Athens, GA; King s College London, London, UK; 4 Diamond Light Source, Didcot, UK; 5 The Scripps Research Inst., La Jolla, CA 4:45 5:0 PM, TUESDAY AFTERNOON AWARD LECTURE Jenny Brodbelt (University of Texas, Austin) presiding Hall, level Presentation of the 06 Research Awards Biemann Medal Kristina Kicki Håkansson University of Michigan 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9

40 5:45-7:00 GENERAL PM TUESDAY INFORMATION WORKSHOPS There are light refreshments in common areas. 0 Glycoproteomics: Site Specific Glycan Analysis Ron Orlando presiding Room 0, level Modulating the activities and functions of proteins is a significant role of post-translational modifications (PTMs), with glycosylation being an excellent example. Glycan moieties of glycoproteins affect protein folding, stability, and localization and thus play a role in numerous biological functions, including cell signaling, adhesion, and communication. The analysis of released glycans has been a primary focus of glyco-analytical development over the past several years. However, these glycan centric analyses do not provide information on the glycans present at each glycosylation sites. Often the site occupancy is critical for biological activity. This behavior is clearly shown with therapeutic antibodies, where glycans located in the variable domain influence the serum clearance rate while glycans in constant domain affect the activity. The comprehensive characterization of protein glycosylation microheterogeneity entails the identification and quantitation of isomeric glycan occupancy of potentially all glycosylation sites on a protein, which is a significantly more difficult challenge than glycomic profiling. This workshop critical evaluation of state-of-the-art methods currently employed for enrichment and analysis at a glycoproteomic level. 0 Ion Mobility: How to Interpret the Data (Ion Mobility MS Interest Group) Erin Baker, Valerie Gabelica, and Stephen Valentine presiding Room, level Over the past decade, MS instrumentation featuring various forms of mobility-based separations have proliferated. One hurdle to intra- and inter-instrumental platform data comparison is, however, the lack of common interpretation schemes and practical tools. In part this results from gaps in knowledge related to correct data interpretation. This workshop will discuss the tools currently available for ion mobility data analyses, and participants will be invited to show tricky cases where data analysis can lead to ambiguous or erroneous interpretations. The workshop discussion will help make progress toward finding common ground and sound fundamental principles for the correct interpretation of ion mobility data. 0 H/D Exchange, Covalent Labeling & Cross-Linking (H/D Exchange, Covalent Labeling & Cross-Linking Interest Group) Joshua Sharp and David Weis presiding Room 5A, level This workshop will provide a forum for discussing hydrogen exchange, covalent labeling, and cross-linking approaches for protein analysis (structure, function, folding, dynamics). There will be a several brief presentations introducing late-breaking advances in MS-based methods, experiments, data analysis, and applications to the attendees. The goal of these abbreviated presentations will be to stimulate discussion. There will be ample time for questions and answers including an opportunity for novices/students to contribute anonymous questions on fundamentals. 04 Food Safety & Security: HRMS Applications (Flavor, Fragrance & Foodstuff Interest Group) Walter Hammack and David Schroeder presiding Room 5B, level A continued discussion of applications and developments in the use of High Resolution Mass Spectrometry (HRMS) in food safety and food security. A focus on new developments and applications in pesticide residue analysis, non-target screening, and natural product authenticity. 05 Microcontrollers and Microcomputers: Emerging Technologies Vincent Sica and Bindesh Shrestha presiding Room 5C, level Smaller is becoming better - computers as smart phones, nanotechnology, miniature mass spectrometers, even tiny homes! The latest trend in do-it-yourself (DIY) electronics is microcontrollers (i.e. Arduino) and microcomputers (i.e. Raspberry Pi). These small, yet powerful devices have put electronic innovation right into our hands. Sensors, displays, and detectors can all be added at a whim without requiring the knowledge of advanced computer circuitry. This year s discussion will focus on the implementation and use of microcontrollers and microcomputers to support advancements in the field of mass spectrometry. Short presentations showcasing applications of this technology will be followed by the discussion of the following topics: ) Hardware (microcontrollers and microcomputers) ) Software/code ) Where to begin/which microelectronic is right for you? ) Utility of DIY-microelectronics in mass spectrometry 4) Add-ons of the future (what type of sensors, displays, and detectors could really help push advancement in MS?) 5) Ideas (Active audience participation is encouraged to discuss new ideas/concepts/suggestions) These discussions aim to not only educate others on how they can improve their research with microcontrollers and microcomputers, but also to spark ideas on what the future may bring to the growing technologies of both microelectronics and mass spectrometry. 06 DNA/RNA Adducts: Assay Development in Detection and Quantification (Oligonucleotides and Nucleic Acids Interest Group) Patrick Limbach and Laixin Wang presiding Room 5D, level Recent mass spectrometry developments now enable high sensitivity detection of DNA or RNA adducts (or modifications). This workshop will focus on the practical issues involved in developing MS-friendly assays to measure these adducts. Selected presentations will illustrate assay development with a focus on sample prep, HPLC conditions, and data analysis. An emphasis in these informal discussions will be on pitfalls and what did not work to freely share strengths and weaknesses of assay development. The remaining time will be spent discussing challenges facing MS assays, especially given the advantages now being presented by high-throughput genome-based technologies. 07 Petroleum and Biofuels: Handling the Data (Energy, Petroleum & Biofuels Interest Group) Mark Barrow and Lateefah Stanford presiding Room 0A, level Petroleum-related mass spectra, often acquired using ultrahigh resolution instruments, are well-known for their complexity. With coupling of ion mobility and chromatography becoming more widespread, the level of complexity will be expected to significantly increase. Accompanying this, issues such as data size, data analysis, usage of chemometrics, software development, and comparisons of results from different analytical techniques will become progressively important. The workshop will highlight some of the existing approaches and will focus upon an active discussion of the current and emerging challenges. 08 Metabolism of Biotherapeutics: When, Why and How? (DMPK Interest Group) Kevin Bateman and Philip Tiller presiding Room 0BC, level Biotherapeutics are a steadily growing proportion of the pharmaceutical research and development landscape. Molecules are evolving beyond traditional monoclonal antibodies and antibody-drug conjugates PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

41 5:45-7:00 PM TUESDAY WORKSHOPS to include bispecifics, truncated mabs, nanobodies, cyclic and stapled peptides, Ig fragments, Non-Ig based scaffolds and so on. Understanding the metabolism of these new modalities is an expanding opportunity for mass spectrometry and requires that traditional small molecule scientists adapt to these new large(r) molecules. The goal of this workshop is to stimulate a discussion on the when, why and how for the metabolism of biotherapeutics in the discovery, pre-clinical and clinical arena. A panel will offer opening comments on the current state and provide thoughts on where the field is going. Questions from the audience will be strongly encouraged to stimulate robust discus 09 Modification of Commercial Instruments for Fundamental Research (Fundamentals Interest Group) Alessandra Ferzoco and Michael Van Stipdonk presiding Room 0A, level It was once the case that building instruments from scratch was essential for fundamental gas phase ion chemistry research. More recently it seems that the rather astounding performance of commercial instruments and increasing pressure for short project time frames has sparked a trend of modifying commercial instruments and working within academic/industrial collaborations. The purpose of the workshop is to explore the elements of effective instrument design within such collaborations. A variety of instruments that range in purpose and invasiveness of the modification will be presented, and both the researchers and company representatives will be present for discussion. We hope the workshop will provide guidance for researchers designing experiments and deciding where to be on the continuum between building from scratch and near-in-tact commercial instruments. 0 Lipidomics in the Era of Systems Biology: The Big Fat Challenges (Lipids and Lipidomics Interest Group) Christer Ejsing and Todd Mitchell presiding Room 0BC, level There is a growing interest in using lipidomics for systems biology studies for understanding the molecular underpinnings of cellular processes and mechanisms of diseases. This workshop will focus on key challenges in integrating lipidomics with other -omics technologies, and how computational strategies can be designed to support meaningful insights into (patho)physiological processes. The discussion will be led by a panel of experts who will invite opinion from participants on current solutions and challenges in using lipidomics for systems biology studies of lipid function in both basic and clinical sciences. Undergraduate Research in Mass Spectrometry (Undergraduate Research in MS Interest Group) Elaine Marzluff and Megan Gessel presiding Room 0A, level This panel discussion, aimed at undergraduate students and their mentors, will focus on helping undergraduate students leverage their undergraduate research experiences into successful scientific careers. Panelists will discuss their experiences applying to graduate school and transitioning to a graduate school research environment, as well as working in industrial labs. private, shared with a specified group of collaborators, or made entirely public. Software tools can be added through a software developer s kit. These tools provide analytical workflows and can be made accessible to the community. Our recent focus has been the integration of analytical workflows such as Byonic, Comet, MaxQuant, PeakExplorer, Pecan, and Skyline. Data Independent Acquisition (Data Independent Acquisition Interest Group) Ludovic Gillet and Jarrett Egertson presiding Room 04, level Data independent acquisition (DIA) is a versatile mass spectrometry approach that aims to comprehensively record time-resolved fragment ion (MS/MS) signals for all detectable analytes in a sample. To identify and quantify analytes from those complex time- and mass-continuous MS/MS data structures, a diverse panel of analysis strategies is now available. These include leveraging spectral libraries, adapting DIA data for traditional database search engines, redesigning search engines to handle highly chimeric spectra, and detecting peptides/ analytes based on extracted chromatograms. Notably, some strategies begin with a collection of features derived from the data (e.g. individual spectra, groups of spectra, or co-eluting peaks) and aim to interpret those features to generate identifications. Other strategies begin with a collection of analytes (e.g. a list of peptides) and query the data for evidence of detection. Each strategy can also differ in the modeling of a decoy scoring distribution and ultimately the assessment of false discovery rate. This workshop aims to disentangle the wealth of DIA analysis strategies available, to discuss the advantages and disadvantages of each approach, and to propose the adoption of a consensus nomenclature to meaningfully refer to them in future DIA studies. 4 Good Manufacturing Practice (GMP); Mass Spectrometric Instrument Qualification Gyorgy Vas presiding Room 05, level This workshop will focus on initiating a discussion between the instrument users regulators and the instrument vendors, to discuss issues relating to regulatory compliance. More rigorous regulatory expectations are requiring higher instrument qualification standards and more involved calibration processes. This workshop is intended to discuss best practice approaches and potential qualification issues. AFTER 8:00 PM CORPORATE HOSPITALITY SUITES GRAND HYATT HOTEL The Chorus Project: Sustainable Cloud Solution for MS Data Michael MacCoss, Andrey Bondarenko, Christine Wu, and Nathan Yates presiding Room 0BC, level The storage, sharing, analysis, and public dissemination of mass spectrometry data is a major challenge for our community. The lack of permanent infrastructure and sustainability is clearly exemplified by the discontinuation of noted resources such as Tranche, NCBI Peptidome, and more recently, the NHGRI s announcement that the funding for many key data resources are in jeopardy. Chorus provides the framework to facilitate a community supported solution to big data generated by the mass spectrometry field. Chorus is a professionally developed application that has a graphical user interface targeted towards the organization and visualization of mass spectrometry data stored on the Amazon cloud. Uploaded data can be exclusive and 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 4

42 WEDNESDAY GENERAL MORNING INFORMATION ORAL SESSIONS 8:0-0:0 am Wednesday Energy, Petroleum and Biofuels: Structure, Quantification, and Data Analysis Patrick G. Hatcher (Old Dominion University) Hall, level WOA am 08:0 In ESI-source H/D Exchange Facilitated a Structural Characterization of Individual Compound in Complex Mixtures by FTICR MS; Alexey S Kononikhin, ; Yury Kostyukevich, ; Alexander Zherebker 4 ; Igor A Popov, 5 ; Oleg N Kharybin, 6 ; Evgeny Kukaev, 5 ; Andrey Konstantinov 4 ; Irina V Perminova 4 ; Eugene Nikolaev,, 5, 6, 7 ; Moscow Institute of Physics and Technology, Moscow, Russia; Institute for Energy Problems of Chemical Physics, Moscow, Russia; Skolkovo Institute of Science and Technology, Skolkovo, Russia; 4 Lomonosov Moscow State University, Moscow, Russia; 5 Emanuel Institute of Biochemical Physics, Moscow, Russia; 6 Institute of Biomedical Problems RAS, Moscow, Russia; 7 Skolkovo Institute of Technology, Moscow, Russia WOA am 08:50 Characterization of Organic Indicator Compounds of Petroleum Biosouring using Novel Soft Ionization and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry; Jeremy Nowak ; Robin Weber ; Pravin Shrestha ; Dana Loutey ; Amy McKenna ; John Coates ; Allen Goldstein ; UC Berkeley, Berkeley, California; National High Magnetic Field Laboratory, Tallahassee, FL WOA am 09:0 High-resolution Broad Mass Range Collision- Energy Scanning Tandem Mass Spectrometry for Structural Characterization of Asphaltene Molecular Ions; Xueming Dong ; Xin Lu ; Yuyang Zhang ; Weijuan Tang, ; Hilkka Kenttamaa ; Purdue University, West Lafayette, IN; Harbin Institute of Technology, Harbin, China; Dow AgroSciences, Indianapolis, IN WOA am 09:0 Multidimensional Comprehensive Gas Chromatography with High Resolution-TOFMS/ photo Ionization-TOFMS: Combining Ultrahigh Chromatographic Resolution, Accurate Mass-information and Soft Photoionisation for Petrochemical Samples; Thomas Groeger ; Maximilian Jennerwein ; Benedikt Weggler ; Mohammad Saraji-Bozorgzad ; Juergen Wendt 4 ; Ralf Zimmermann 5 ; Helmholtz Zentrum Muenchen, Oberschleissheim, Germany; ASG GmbH, Augsburg, Germany; Photonion GmbH, Schwerin, Germany; 4 LECO Instrumente GmbH, Moenchengladbach, Germany; 5 University of Rostock, Rostock WOA am 09:50 Reaction Pathway Analysis using Isotopically- Labeled Glucose in Real-Time Monitoring of Thin-Film Fast Pyrolysis; Carolyn Hutchinson ; Kristen O Connor ; Young Jin Lee ; Iowa State University, Ames, IA WOA am 0:0 UPLC-MS and MS/MS of Grass Lignins: Evidence for New Structural Units and Cross- Linkers; Afrand Kamali Sarvestani, ; Leonardo Da Costa Sousa, 4 ; Venkatesh Balan, 4 ; Xiaoxiao Liu ; Bruce Dale, 4 ; A Daniel Jones III,, 5 ; Department of Chemistry, Michigan State University, East Lansing, MI; DOE Great Lakes Bioenergy Research Center, Michigan State University, East Lansing, MI; Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI; 4 DOE Great Lake Bioenergy Research Center, Michigan State University, East Lansing, MI; 5 Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI PAGE 4 8:0-0:0 am Wednesday Fundamentals: Energetics and Mechanisms of Uni and Bimolecular Reactions John R. Stutzman (The Dow Chemical Company) Room, level WOB am 08:0 Mechanistic Study of Gas Phase In-source Hofmann Elimination of Doubly Quaternized Cinchona-Alkaloid Based Phase-Transfer Catalysts by (+)-ESI/Tandem Mass Spectrometry; Huaming Sheng ; Rong-Sheng Yang ; Katrina M Lexa ; Edward Sherer ; Li-Kang Zhang ; Bangping Xiang ; Roy Helmy ; Merck, Darmstadt, Germany WOB am 08:50 Probing the Effect of Charge on the Energetics and Reactivity of Distonic Peroxyl Radical Ions in the Gas Phase; Peggy Williams ; Nadia Skeljo ; David Marshall ; Benjamin Kirk ; Berwyck Poad, ; Stephen Blanksby ; Queensland University of Technology, Brisbane, Australia; Lawrence Berkeley Nat l Lab, Berkeley, CA; University of Wollongong, Wollongong, Australia WOB am 09:0 Computational and Experimental Investigation of Gas Phase Ion/Ion Reactions between Nucleophiles and HOAt/HOBt Reagents; Jiexun Bu ; Feifei Zhao ; Scott A McLuckey ; Purdue University, West Lafayette, IN WOB am 09:0 Photo-Electron Transfer Dissociation Pathways Reveal Zwitterion Locations in Peptides; Ryan R. Julian; University of California, Riverside, Riverside, CA WOB am 09:50 Reactions of Hydroxyl Radicals and Cysteine Disulfide Derivatives (CySSR) Mechanism and Reactivity Studies; Sarju Adhikari ; M. Anglada Josep ; Joseph S. Francisco ; Yu Xia 4 ; Purdue University, West Lafayatte, IN; Institute of Advanced Chemistry of Catalonia, Barcelona, Spain; University of Nebraska-Lincoln, Lincoln, NE; 4 Purdue University-Department of Chemistry, West Lafayette, IN WOB am 0:0 Radical-Mediated Peptide Tyrosine Nitration In Vacuo: Experimental Evidence and Theoretical Examination; Ivan K. Chu ; Cheuk Kuen Lai ; Wai Kit Tang ; Chi-Kit Siu ; University of Hong Kong, Hong Kong; The University of Hong Kong, Hong Kong, China; City University, Hong Kong, Hong Kong 8:0-0:0 am Wednesday Imaging: Pharmaceuticals and Metabolites Livia D. Eberlin (University of Texas at Austin) Stars Ballroom, level WOC am 08:0 C60-SIMS Imaging of Pharmaceutical Compounds within Mammalian Cells; Anna N Bloom ; Hua Tian ; Nicholas Winograd ; Pennsylvania State University, University Park, PA WOC am 08:50 Spatio-temporal Metabolomics of Tumor Organoids Treated with Chloroquine; Andrew Palmer ; Eric Weaver ; Katherine A Kellersberger ; Amanda B Hummon ; Theodore Alexandrov ; EMBL Heidelberg, Heidelberg, Germany; University of Notre Dame, Notre Dame, Indiana; Bruker Daltonic, Billerica, MA WOC am 09:0 Mass Spectrometry Imaging for Characterizing Parasite Host Interactions in Malaria Research; Saleh Mahmud Khalil ; Andreas Römpp ; Jette Pretzel ; Katja Becker ; Bernhard Spengler ; Institute of Inorganic and Analytical Chemistry, Justus Liebig University, Giessen, Hessen,Germany; Biochemistry and Molecular Biology, Institute of Nutritional Sciences, Justus Liebig University, Giessen, Hessen,Germany 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

43 WEDNESDAY MORNING ORAL SESSIONS WOC am 09:0 Simultaneous Desorption Electrospray Ionization Mass Spectrometry Imaging of Multiple Neurotransmitters and Neuroactive Substances; Mohammadreza Shariatgorji ; Nicole Strittmatter ; Anna Nilsson ; Theodosia Vallianatou ; Per Svenningsson 4 ; Richard J A Goodwin ; Per E Andren ; Uppsala University, Uppsala, Sweden; AstraZeneca, Cambridge, UK; Uppsala University, Uppsala; 4 Karolinska Institute, Stockholm, Sweden WOC am 09:50 Visualizing Tumors in Three Dimensions: a First Look at Drug Distribution in Brain Tumors using D MSI; David Calligaris ; Armen Changelian ; Katherine A Kellersberger ; Yonatan Morocz ; Forest White ; Jeffrey N Agar 4 ; Jann N Sarkaria 5 ; Nathalie Y. R. Agar ; Department of Neurosurgery, and Department of Radiology, BWH, and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Bruker Daltonics, Billerica, MA; Massachusetts Institute of Technology, Boston, MA; 4 Department of Chemistry and Pharmaceutical Sciences, Northeastern University, Boston, MA; 5 Department of Radiation Oncology, Mayo Clinic, Rochester, MN WOC am 0:0 Growth, Metabolism, and Antibiotic Susceptibility of Bacterial Colonies Imaged by Laser Ablation Electrospray Ionization Mass Spectrometry; Hang Li ; Pranav Balan ; Akos Vertes ; George Washington University, Washington, DC; Thomas Jefferson High School for Science and Technology, Alexandria, VA 8:0-0:0 am Wednesday Instrumentation: Miniaturization of MS Christopher C. Mulligan (Illinois State University) Stars Ballroom -, level WOD am 08:0 Development of a Point-of-Care (POC) Miniature Mass Spectrometry System; Xiao Wang ; Yue Ren ; Li Linfan ; Xinwei Liu ; Zheng Ouyang, ; Purdue University, West Lafayette, IN; Tsinghua University, Beijing, China WOD am 08:50 LITMS: Dual Ion Source Switchable Polarity Linear Ion Trap Mass Spectrometer for Space Flight Applications; Andrej Grubisic, ; William B Brinckerhoff ; Friso Van Amerom ; Ryan Danell 4 ; Veronica T Pinnick 5 ; Ricardo Arevalo ; Xiang Li 5 ; Stephanie Getty ; Daniel Glavin ; Lars Hovmand 6 ; Phil Chu 7 ; Kris Zacny 7 ; Steve Rogacki 8 ; Timothy J Cornish 9 ; Paul Mahaffy ; University of Maryland, College Park, MD; NASA GSFC, Greenbelt, MD; Mini-Mass Consulting, Inc., Hyattsville, MD; 4 Danell Consulting, Inc. Winterville, NC; 5 University of Maryland, Baltimore County Greenbelt, MD; 6 Linear Labs LLC, Washington DC, DC; 7 Honeybee Robotics, Pasadena, CA; 8 University of Michigan, Ann Arbor, MI; 9 C&E Research, Inc. Columbia, MD WOD am 09:0 Reverse Gas Stack Model for Localization of Chemical Interests Utilizing Mobile Mass Spectrometry; Phillip Mach ; Kenneth C Wright ; Guido F Verbeck ; University of North Texas, Denton, TX; Inficon, Syracuse, NY WOD am 09:0 minisplat:a Miniaturized Aircraft- CompatibleSingle Particle Mass Spectrometer for in-situ Quantitative Multidimensional Single Particle Characterization; Alla Zelenyuk ; Dan Imre ; Jacqueline Wilson ; David Bell ; Pacific Northwest National Laboratory, Richland, WA; Imre Consulting, Richland, WA WOD am 09:50 Development and Applications of Microchip Capillary Electrophoresis Coupled with High Pressure Mass Spectrometry; William McKay Gilliland ; John Michael Ramsey ; University of North Carolina at Chapel Hill, Chapel Hill, NC WOD am 0:0 Multi-sample Reaction Monitoring: a Miniature Process Analytical Tool using a Miniature Ion Trap; Christopher J Pulliam ; Ryan M Bain ; Heather l. Osswald ; Dalton T Snyder ; Stephen Ayrton ; Shannon Raab ; R. Graham Cooks ; Purdue University, West Lafayette, IN 8:0-0:0 am Wednesday Biomarkers: Qualitative Analysis Jennifer Van Eyk (Cedars-Sinai Medical Center) Stars Ballroom 4, level WOE am 08:0 Organismal Level Dynamic Molecular Map of Mouse Proteome; Bingyun Sun ; Shizhen Qin ; Cynthia Lorang ; Gray Li ; Zhiyuan Hu ; Ken Liu ; Leory Hood ; Simon Fraser University, Burnaby, BC; Institute for Systems Biology, Seattle, WA; Simon Fraser University, Burnaby, BC, Canada WOE am 08:50 Intact Metabolome Analysis of Mice Biological Tissues by Probe Electrospray Ionization- Tandem Mass Spectrometry and Its Preliminary Application to Real-Time Analysis; Kei Zaitsu ; Yumi Hayashi ; Tasuku Murata ; Hiroki Nakajima ; Tetsuya Ishikawa ; Maiko Kusano ; Hitoshi Tsuchihashi ; Akira Ishii ; Nagoya University Graduate School of Medicine, Nagoya, Japan; Global Application Development Center, Shimadzu Corporation, Kyoto, Japan WOE am 09:0 Imaging Mass Spectrometry Identifies New Markers in Prostate Cancer Pathology; Kristina Schwamborn ; Peter Wild ; Jeremy L Norris ; Richard M Caprioli ; Technical University Munich, Munich; Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland; Department of Biochemistry and the Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN WOE am 09:0 Top-down Proteomics Identified Novel Biomarkers for Hypertrophic Cardiomyopathy; Wenxuan Cai ; Zachery Gregorich ; Andrew Messer ; Ziqing Lin ; Zachary Hite ; Steve Marston ; Takushi Kohmoto ; Ying Ge ; University of Wisconsin-Madison, Madison, WI; Imperial College London, London, UK WOE am 09:50 Profiling of Intact Proteins in the CSF of Alzheimer s Disease Patients using Top Down Proteomics: Revealing Specific Isoform Biomarker Candidates; Jerôme Vialaret ; Schmit Pierre-Olivier ; Audrey Gabelle ; Christophe Hirtz ; Sylvain Lehmann ; LBPC-IRB, CHU de Montpellier Montpellier, France; Bruker Daltonique S.A., Wissembourg, bas-rhin; Centre Mémoire Ressources Recherche, Montpellier, france WOE am 0:0 A Mass Spectrometry Approach to Discover Naturally-occurring Oxidation-specific Malondialdehyde Adducts; Juliane Weißer ; Christoph J Binder, ; Keiryn L Bennett ; CeMM Research Center for Molecular Medicine, Vienna, Austria; Medical University of Vienna, Vienna, Austria 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 4

44 WEDNESDAY GENERAL MORNING INFORMATION ORAL SESSIONS 8:0-0:0 am Wednesday Informatics: Multiomics Integration and Application Catherine Minogue (Hartwick College) Hemisfair Ballroom, level WOF am 08:0 WOF am 08:50 WOF am 09:0 WOF am 09:0 WOF am 09:50 WOF am 0:0 Integrating and Mining Spatial Omics through Imaging Mass Spectrometry and Anatomical Atlases; Nico Verbeeck ; Jeffrey Spraggins ; Junhai Yang ; Etienne Waelkens, 4 ; Richard M. Caprioli ; Raf Van de Plas ; Delft University of Technology, Delft, The Netherlands; Vanderbilt University, Nashville, TN; KU Leuven, Leuven, Belgium; 4 Sybioma, Leuven, Belgium Mitochondrial Protein Functions Revealed by Global Mass Spectrometry Profiling; Jonathan A Stefely, ; Nicholas W Kwiecien ; Alexander S Hebert ; Alicia L Richards ; Elyse C Freiberger ; Matthew J P Rush ; Arne Ulbrich ; Adam Jochem ; Michael T Veling ; Paul D Hutchins ; Harald Marx ; Michael S Westphall ; David J Pagliarini, ; Joshua J Coon ; University of Wisconsin Madison, Madison, Wisconsin; Morgridge Institute for Research, Madison, Wisconsin Incorporating Multiple Information Layers to Understand Viral Antigen Presentation: Stepping Away from the Streetlamp; Kavya Swaminathan ; Peder J Lund ; Caleb D Marceau ; Niclas E Olsson ; Mark M Davis ; Jan Carette ; Joshua E Elias ; Stanford University, Stanford, CA Quantitative Proteogenomics for Personalised Molecular Profiling; Christoph Schlaffner, ; Theodoros Roumeliotis ; Hendrik Weisser ; James Wright ; Jonathan Mudge ; Sergio Santos 4 ; Graham Ritchie 4, 5, 6, 7 ; Julia Steinberg 5 ; Andreas Bender ; Alvis Brazma 4 ; Jennifer Harrow ; Christine Le Maitre 8 ; Mark Wilkinson 9 ; Eleftheria Zeggini 5 ; Jyoti Choudhary ; Proteomic Mass Spectrometry, Wellcome Trust Sanger Institute, Cambridge, UK; Department of Chemistry, University of Cambridge, Cambridge, UK; Human and Vertebrate Analysis and Annotation Team, Wellcome Trust Sanger Institute, Cambridge, UK; 4 European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, UK; 5 Department of Human Genetics, Wellcome Trust Sanger Institute, Cambridge, UK; 6 Usher Institute of Population Health Sciences & Informatics, University of Edinburgh, Edinburgh, UK; 7 MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK; 8 Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK; 9 Department of Human Metabolism, University of Sheffield, Sheffield, UK Integrated Analysis of Human Tissues with a Multi-Omics Approach; Hannes Hahne, ; Dongxue Wang ; Björn Hallström ; Lihua Li ; Anna Asplund 4 ; Mathias Wilhelm, ; Harald Marx 5 ; Frederik Ponten 4 ; Mathias Uhlen ; Bernhard Kuster ; OmicScouts GmbH, Freising, Germany; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany; KTH Royal Institute of Technology, Stockholm, Sweden; 4 Uppsala University, Uppsala, Sweden; 5 University Wisconsin- Madison, Madison Integration of Multiple Omics Data Sets via Application of OnPLS Methodology; Johan Trygg ; Izabella Surowiec ; Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden 8:0-0:0 am Wednesday MS in the QC Lab Da Ren (Amgen) Hemisfair Ballroom, level WOG am 08:0 Application of Mass Spectrometry in the Quality Control Related Investigations During Protein Therapeutics Manufacturing and Stability Studies; Li Tao; Bristol-Myers Squibb Co., New Hope, PA WOG am 08:50 Monitoring Product Attributes in Biopharmaceutical Development and QC with LC/HRMS; Scott Berger ; Liuxi Chen ; Min Du ; Henry Y Shion ; Ying-Qing Yu ; Waters Corporation, Milford, MA WOG am 09:0 Extending the Capabilities of a MS Based Multi Attribute Characterization Method to Promote Quality by Design In Biotherapeutic Drugs; Michael Blank ; Jonathan L Josephs ; Richard Rogers ; Thermo Fisher Scientific, San Jose, CA; Just Biotherapeutics, Seattle, WA WOG am 09:0 Development of QC-Friendly Mass Spec Assay for Monitoring Antibody Oxidation; Izabela Sokolowska ; Jingjie Mo ; Jia Dong ; Michael J Lewis ; Ping Hu ; Janssen Research & Development, Malvern, PA WOG am 09:50 O-linked Glycosylation for a Fc Fusion Protein: Characterization and Understanding of Biological Relevance; Le Zhang ; Wael Hamouda ; Joshua Pearson ; Xiaoyan Guan ; Hyo Chung ; Jette Wypych ; Amgen, Inc., Thousand Oaks, CA WOG am 0:0 Practical Applications of Mass Spectrometry in a Quality Control Laboratory; Patrick Bulau; Roche Diagnostics GmbH, Penzberg, Germany 8:0-0:0 am Wednesday Macromolecular Complexes Mowei Zhou (Pacific Northwest National Laboratory) Hemisfair Ballroom, level WOH am 08:0 A Native Proteomics Platform for Untargeted Identification and Characterization of Protein Complexes; Owen Skinner ; Rafael Melani ; Luca Fornelli ; Nicole Haverland ; Luis Henrique Ferrer Do Vale ; Henrique Seckler ; Peter Doubleday ; Luis Schachner ; Neil L Kelleher ; Compton Philip ; Northwestern University, Evanston, IL WOH am 08:50 Towards Routine Native Mass Spectrometric Analysis of Affinity-Isolated Endogenous Protein Complexes; Paul Dominic B. Olinares ; Amelia D Dunn ; Julio C Padovan ; Javier Fernandez- Martinez ; Michael P Rout ; Brian T Chait ; The Rockefeller University, New York, NY WOH am 09:0 Integrating Native MS, Crosslinking-MS and HDX-MS with High-Resolution Cryo- Electron Microscopy Reveals the Molecular Architecture of the Sub-Megadalton Circadian Oscillator KaiCBA; Philip Lössl ; Joost Snijder,, ; Jan Michael Schuller 4 ; Anika Wiegard 5 ; Ilka M Axmann 5 ; Jürgen M Plitzko 4 ; Friedrich Förster 4 ; Albert J R Heck, ; Utrecht University, Utrecht, The Netherlands; Netherlands Proteomics Center, Utrecht, The Netherlands; University of Washington, Seattle, WA; 4 Max Planck Institute for Biochemistry, Martinsried, Germany; 5 Heinrich Heine University, Dusseldorf, Germany WOH am 09:0 Mobile-Proton MD Simulations for Modeling the Dissociation of Electrosprayed Protein Complexes; Vlad Popa ; Danielle Trecroce ; Robert G McAllister ; Lars Konermann ; University of Western Ontario, London, Canada PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

45 WEDNESDAY AFTERNOON ORAL SESSIONS WOH am 09:50 Confirmation of Subunit-Subunit Connectivity and Topology of Computationally Designed Protein Complexes using Surface Induced Dissociation/Ion Mobility; Aniruddha Sahasrabuddhe ; Yang Hsia ; Florian Busch ; David Baker ; Vicki Wysocki ; The Ohio State University, Columbus, OH; University of Washington, Seattle, WA WOH am 0:0 Native Top-Down IRMPD of Macromolecular Protein Complexes Game Over or Game Changing?; Huilin Li ; Shirin Jamshidi ; Hong Hanh Nguyen ; Iain Campuzano ; Rachel O Loo ; Joseph A Loo ; UCLA, Los Angeles, CA; University of Warwick, Coventry, United Kingdom; Amgen, Inc., Thousand Oaks, CA 0:0 AM :0 PM, WEDNESDAY WEDNESDAY POSTER SESSION Poster/Exhibit Hall Lunch concessions are open :00 am :00 pm Odd-number posters present 0:0 am - :00 pm Even-number posters present :00 - :0 pm WEDNESDAY AFTERNOON ORAL SESSIONS :0-4:0 pm Wednesday Exposomics: Targeted, untargeted and bioinformatics methodologies David M. Balshaw (National Institute of Environmental Health Sciences, National Institutes of Health) Hall, level WOA pm 0:0 Causal Biomarker Discovery of Childhood Leukemia by Untargeted Metabolomics of Neonatal Dried Blood Spots; Lauren Petrick ; William MB Edmands ; Courtney L Schiffman ; Alan Hubbard ; Stephen M Rappaport ; UC Berkeley, Berkeley, CA WOA pm 0:50 High-coverage Metabolomic Analysis of Microliter Blood Using Isotope Labeling and High-resolution LC-MS; Wei Han ; Liang Li ; Department of Chemistry, University of Alberta, Edmonton, AB, Canada WOA pm 0:0 Improving Detection and Coverage of Microbially-derived Metabolites using GC-MS Based Strategies for Targeted and Untargeted Profiling; Bhavapriya Vaitheesvaran ; Vladimir Yong ; Anthony Macherone ; Justin R Cross ; Memorial Sloan Kettering Cancer Center, New York, NY; Agilent Technologies, Little Falls, DE WOA pm 0:0 Novel Metabolites Revealed by High Resolution Orbitrap Mass Spectrometry and Their Implications in Quantitation of Urinary Exposure Markers; Jen-Yi Hsu ; Jing-Fang Hsu ; Yi-Jen Chen ; Pao-Chi Liao ; National Cheng Kung University, Tainan, Taiwan WOA pm 0:50 An Exposomic Study of Health Assessment of Children with Autism and Control Children Using New Mass Spectrometry Methods for Quantitation; H M Skip Kingston ; Scott Faber ; Patrick benecewicz ; Duquesne University, Pittsburgh, PA; The children Institute, Pittsburgh, PA WOA pm 04:0 Detection and Identification of Generally Unknown Toxins and Altered Endogenous Components in Poisoned Patients using Data-Independent Acquisition and Untargeted Metabolomics; Cheng Chen ; Ziquan Fan ; Xiaojie Tan ; Hui Xu ; Hongliang Jiang ; Mingshe Zhu 4 ; Huazhong University of Science and Technology, Wuhan, China; Waters Technology (Shanghai) Co., Ltd, Shanghai, China; Maternal and Child Health Hospital of Hubei Province, Wuhan, China; 4 Bristol- Myers Squibb, Princeton, NJ :0-4:0 pm Wednesday Fundamentals: Molecular Modeling and Quantum Mechanical Calculations in IM and MS Iain D. G. Campuzano (Amgen) Room, level WOB pm 0:0 Molecular Dynamics/Kinetic Theory Algorithm for Numerical Determination of Electrical Mobility; Carlos Larriba Andaluz; Indiana University- Purdue University Indianapolis, Indianapolis, IN WOB pm 0:50 Using Molecular Dynamics Simulations to Uncover the Mechanism of Supercharging in Protein ESI; Lars Konermann ; Haidy Metwally ; Robert G McAllister ; Vlad Popa ; Univ. of Western Ontario, London, ON; Univ. of Western Ontario, London, Canada WOB pm 0:0 Multi-scale Simulations Coupled with Ion Mobility Experiments Reveal the Fate of nucleic Acids in the Gas Phase; Massimiliano Porrini,, ; Clémence Rabin,, ; Josephine Abi- WOB pm 0:0 WOB pm 0:50 WOB pm 04:0 Ghanem,, ; Frédéric Rosu 4,, ; Valerie Gabelica ; INSERM-U, ARNA laboratory, Bordeaux, France; CNRS-UMR50, ARNA laboratory, Bordeaux, France; Université de Bordeaux, IECB, ARNA laboratory, Pessac, France; 4 CNRS UMS 0, IECB, University of Bordeaux, Pessac, France How Important is the Charge Distribution in Ion Mobility Experiments, and Can We Predict It?; Jasper Boschmans ; Filip Lemiere ; Frank Sobott ; Owlstone, Cambridge, UK; University of Antwerp, Antwerp, Belgium; University of Antwerp, CGB V4, Antwerp, Belgium Polyproline Fragmentation in Negative Mode. What We Can Learn from Chemical Dynamics Simulations; Ana Martin-Somer ; William L. Hase ; Riccardo Spezia ; Université d Evry-val-d Essonne, Evry, France; Texas Tech University, Lubbock, TX; CNRS, Evry, Île-de-France Computations for the Gas-Phase Study of Macromolecular Structure; Erik G Marklund, ; Matteo T Degiacomi ; Carol V Robinson ; Michael Landreh ; Mathieu Moog ; David Drew ; Carl Caleman, 4 ; Andrew Baldwin ; Justin L P Benesch ; University of Oxford, Oxford, UK; Uppsala University, Uppsala, SE; Stockholm University, Stockholm, Sweden; 4 Center for Free-Electron Laser Science, Hamburg, Germany :0-4:0 pm Wednesday Environmental: Emerging Contaminants Marc E. Engel (FDACS, Food Safety Laboratories) Stars Ballroom, level WOC pm 0:0 Hydraulic Fracturing Impacts on Drinking Water: High Resolution-MS Uncovers New Chemical By-Products; Susan Richardson ; Hannah K. Liberatore ; Jeanne M. VanBriesen ; Plewa J. Michael 4 ; Leslie H. Cizmas 5 ; University of South Carolina, Department of Chemistry and Biochemistry, Columbia, SC; University of South Carolina, Columbia, SC; Carnegie Mellon University, Pittsburgh, PA; 4 University of Illinois, Urbana, IL; 5 Texas A&M, College Station, TX WOC pm 0:50 Heterogeneous Atmospheric Reactions: Identification of the Oxidation Products of Polycyclic Aromatic Hydrocarbons; Richard E. Cochran, ; Shokouh Haddadi, ; Rebeka Fisseha 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 45

46 WEDNESDAY GENERAL AFTERNOON INFORMATION ORAL SESSIONS Derseh ; Alena Kubatova ; University of North Dakota, Grand Forks, ND; University of California San Diego, San Diego, CA; SUNY Oswego, Oswego, NY WOC pm 0:0 Data-independent Mass Spectrometry for Development of Occupational Nanomaterial Exposure Biomarkers; Andrew K. Ottens ; Pretal P. Muldoon ; Aleksandar Vucetic ; Demetrius R. Carter ; Stefan Tenzer ; Matthew J. Campen ; Aaron D. Erdely 4 ; Dept Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA; Institute of Immunology, University of Mainz, Mainz, Germany; Dept Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM; 4 National Institute for Occupational Safety and Health, Centers for Disease Control and Provention, Morgantown, WV WOC pm 0:0 Tracing Gadolinium-based Contrast Agents from Surface Water to Drinking Water by means of Speciation Analysis; Uwe Karst ; Marvin Birka ; Oliver Hachmöller ; Michael Sperling ; Christoph Alexander Wehe ; University of Münster, Münster; University of Münster, Münster, DE WOC pm 0:50 Determination of Unknown Dichlorophenols from the Oxidation of Triclosan Using Hydrogen Peroxide; Matthew Reichert ; Paul M Chiarelli ; Loyola University, Chicago, IL WOC pm 04:0 Identification of Emerging Contaminants from a Waste Water Influenced Water Body Using High Resolution Accurate Mass LC/MS and Statistical Analysis; Jerry Zweigenbaum ; Tarun Anumol ; Linda Kennedy ; Agilent Technologies, Wilmington, DE; Mansfield University of Pennsylvania, Mansfield, PA :0-4:0 pm Wednesday Imaging: Biomedical Applications Bindesh Shrestha (Waters Corporation) Stars Ballroom -, level WOD pm 0:0 Guided DESI-MS Imaging Allows Accelerated Mapping of Heterogeneity in Breast Cancer; Alessandra Tata ; Michael Woolman ; Milan Ganguly ; Manuela Ventura ; Nicholas Bernards ; Adam Gribble ; Alex Vitkin ; Howard Ginsberg ; Arash Zarrine-Afsar ; University of Health Network, Toronto, Canada; University of Toronto, Toronto ON, Canada; St.Michael Hospital, Toronto, Canada WOD pm 0:50 Three-dimensional MALDI Imaging to Understand Metastasis in Pediatric Medulloblastomas; Martin R L Paine ; Jingbo Liu ; Danning Huang ; Shane R Ellis ; Ron M A Heeren ; Facundo M Fernández ; Georgia Institute of Technology, Atlanta, GA; Emory University School of Medicine, Atlanta, GA; Maastricht University, Maastricht, NL WOD pm 0:0 Formalin-Fixed Paraffin Embedded Tissue Analysis by DESI-MSI and its Potential Use in Diagnostics; Renata Soares ; James McKenzie ; Anna Mróz ; Francesca Rosini ; James L Alexander ; Robert Goldin ; Zoltan Takats ; Imperial College London, London, United Kingdom WOD pm 0:0 Redefining the Pathogen-host Interaction: Imaging Mass Spectrometry Reveals Staphylococcus Aureus Proteins within Host Tissues; Jessica Moore ; Neal D. Hammer ; Kristie M Lindsey Rose ; Jeffrey M Spraggins ; James Cassat ; Eric P Skaar ; Richard M Caprioli 4,, 5 ; Vanderbilt University MSRC, Nashville, TN; Michigan State University, East Lansing, MI; Vanderbilt University School of Medicine, Nashville, TN; 4 Vanderbilt University, Nashville, TN; 5 Vanderbilt Dept. of Biochemistry, Nashville, TN WOD pm 0:50 Integrating Mass Spectrometry Imaging with Multiple Microscopy Modalities for Enhanced Spatiochemical Characterization of Dynamic Microbial Communities; Sage J. B. Dunham ; Kyungwon Ko ; Nameera Baig ; Nydia Morales- Soto ; Troy J Comi ; Bin Li ; Joseph F Ellis ; Joshua Shrout ; Paul W Bohn ; Jonathan V Sweedler ; University of Illinois at Urbana-Champaign, Urbana- Champaign, IL; University of Notre Dame, Notre Dame, IN WOD pm 04:0 Biomedical Applications of Cardinal: a Mass Spectrometry Imaging Toolbox for Statistical Analysis.; April Harry ; Kyle D Bemis ; David Calligaris ; Nathalie Agar, ; Olga Vitek 4 ; Purdue University, West Lafayette, IN; Brigham and Women s Hospital, Boston, MA; Harvard Medical School, Boston, MA; 4 Northeastern University, Boston, MA :0-4:0 pm Wednesday Top Down Protein Analysis Si Wu (University of Oklahoma) Stars Ballroom 4, level WOE pm 0:0 Comparing Electron Ionization Dissociation and Ultraviolet Photodissociation for Top-Down Native MS of Proteins and Protein Complexes; Huilin Li ; Yuewei Sheng ; Jennifer S Brodbelt ; Joseph A. Loo ; UCLA, Los Angeles, CA; University of Texas at Austin, Austin, TX WOE pm 0:50 Elucidating Proteoform Families from Proteoform Intact Mass and Lysine Count Measurements; Michael R. Shortreed ; Brian L Frey ; Mark Scalf ; Rachel Knoener ; Anthony J Cesnik ; Lloyd M Smith ; University of Wisconsin Madison, Madison, WI WOE pm 0:0 A Novel Approach to Sequencing Native Protein Complexes with an Orbitrap; Mikhail Belov, ; Philip D Compton ; Neil L Kelleher ; Stevan Horning 4 ; Alexander A Makarov 4 ; Thermo Fisher Scientific (Bremen), Bremen, Germany; Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany; Northwestern University, Evanston, IL; 4 Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany WOE pm 0:0 Chemical Modification as a Path to Improved Top-down Sequencing and Structural Analysis of Proteins and Protein Complexes; Daniel A. Polasky ; Philip C Andrews, ; Brandon T. Ruotolo ; Department of Chemistry, University of Michigan, Ann Arbor, MI; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI WOE pm 0:50 A Novel Top Down Proteomics Pipeline Utilizing Capillary Electrophoresis Separation and Ultraviolet Photodissociation; Jolene K Diedrich, ; Mathieu Lavallée-Adam ; Qian Chu ; Bryan Fonslow, ; James J Moresco, ; Alan Saghatelian ; John R Yates III, ; The Scripps Research Institute, La Jolla, CA; The Salk Institute, La Jolla, CA; SCIEX, Brea, CA WOE pm 04:0 Novel Strategies for Top-down Phosphoproteomics; Bifan Chen ; Leekyoung Hwang ; Tania Guardado ; William Ochowicz ; Albert Chen ; Cyrus Colah ; Kunal Dani ; Song Jin ; Ying Ge ; University of Wisconsin-Madison, Madison, WI; University of Wisconsin Madison, Madison, Wisconsin PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

47 WEDNESDAY AFTERNOON ORAL SESSIONS :0-4:0 pm Wednesday MS in the Regulatory Environment Jennifer Liu (Amgen) Hemisfair Ballroom, level WOF pm 0:0 The Use of Mass Spectrometry in FDA Applications for Biotherapeutics: A Retrospective Review; Sarah Rogstad ; Anneliese Faustino ; David Keire ; Michael T Boyne ; Jun Park ; FDA, Silver Spring, MD; Food and Drug Administration, St. Louis, MO; Biotechlogic, Chicago, IL WOF pm 0:50 The Roles and Opportunities for Mass Spectrometry in Regulatory CMC Submissions; Heidi Zhang; Genentech, SSF, CA WOF pm 0:0 Quantitative Analysis of Influenza Vaccine Antigens: How Does the Hi Method Compare to Methods Requiring Labeled Isotopes?; Daryl G S Smith ; Lisa Walrond ; Marybeth Creskey ; Genevieve Gingras ; Yves Aubin ; Caroline Gravel ; Sean Li ; Terry D Cyr ; Health Canada, Ottawa, Canada WOF pm 0:0 Development of a LC-SRM Method Based on Anion Attachment Mass Spectrometry for Improved Detection of Neutral Anabolic Androgenic Steroids; Quentin Dumont ; Mariana Barcenas ; Isabelle Bailloux ; Corinne Buisson ; Nathalie Mechin ; Richard B. Cole ; Sorbonne Universités, UPMC Univ Paris 06, Paris, France; Agence Française de Lutte Contre le Dopage, Châtenay-Malabry, France WOF pm 0:50 NISTmAb Reference Material 867: A Tool for Advancing Biopharmaceutical Mass Spectrometry; John SchieL ; Trina Formolo ; Abigail Turner ; Katharina Yandrofski ; NIST, Gaithersburg, MD; NIST, Rockville, MD WOF pm 04:0 The Challenges in Quantifying Tree Nut Residues of Phosphonic Acid and its Salts with LC-MSMS and CESI-MSMS; Wiley Hall ; Bill Beckham ; Spencer Walse ; Thomas Michael Jones ; Leonel Jimenez ; Alan Stone 4 ; DFA of California, Fresno, CA; DFA of California, Fresno, CA - California; USDA-ARS-CPQ, Parlier, CA - California; 4 Johns Hopkins University, Baltimore, MD :0-4:0 pm Wednesday Carbohydrates John Froehlich (Boston Children s Hospital & Harvard Medical School) Hemisfair Ballroom, level WOG pm 0:0 Relative Quantification of Glycans using Multiplexed Carbonyl-Reactive Tandem Mass Tags and MultiNotch MS; Bingming Chen ; Xuefei Zhong ; Sergei Snovida ; John Rogers ; Lingjun Li ; University of Wisconsin-Madison, Madison, WI; Thermo Fisher Scientific, Rockford, IL WOG pm 0:50 Highly Sensitive N-and O-glycomics From Archived Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Sections Using Porous Graphitized Carbon (PGC)-nanoLC-ESI-MS/ MS; Hannes Hinneburg, ; Petra Korac ; Slavko Gasparov 4, 5 ; Peter H Seeberger, ; Vlatka Zoldos ; Daniel Kolarich ; Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Berlin, Germany; Faculty of Science, Department of Biology, Division of Molecular Biology, University of Zagreb, Zagreb, Croatia; 4 Institute for Pathology and Cytology, University Hospital Merkur, Zagreb, Croatia; 5 Department of Pathology, Medical School Zagreb, University of Zagreb, Zagreb, Croatia WOG pm 0:0 Measuring Variability of Glycosylation Analysis Methods for Monoclonal Antibodies: A NIST Interlaboratory Study; M. Lorna A De Leoz ; David Lee Duewer ; Stephen E Stein ; National Institute of Standards and Technology, Gaithersburg, MD WOG pm 0:0 Strategies to Improve the Accuracy of De Novo Glycan Topology Analysis; Cheng Lin ; Pengyu Hong ; Yi Pu ; Catherine E. Costello, ; Boston University School of Medicine, Boston, MA; Brandeis University, Waltham, MA; Boston University, Boston, MA WOG pm 0:50 Oligosaccharide Isomer Discrimination by Ion Mobility Spectrometry and Tandem Mass Spectrometry: Roles of Metal Ion Adduction and Gas-Phase Ion Chemistry; Eric D. Dodds ; Yuting Huang ; Katherine N. Schumacher ; Abby S. Gelb ; Lauren Petrosh ; University of Nebraska - Lincoln, Lincoln, NE WOG pm 04:0 Temporal Glycan Analysis of IgG and Paraprotein from Multiple Myeloma Reveals Strong Pathological Associations with Altered Glycosylation; Stefan Mittermayr ; Giao Le, ; Peter O Gorman ; Jonathan Bones ; The National Institute for Bioprocessing Research & Training, Dublin, Ireland; Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland; Department of Haematology, Mater Misericordiae University Hospital, Dublin 7, Ireland, Dublin, Ireland :0-4:0 pm Wednesday New Separations Approaches Coupled to MS Michael L. Heien (University of Arizona) Hemisfair Ballroom, level WOH pm 0:0 Fundamentals of Ion Dynamics in Structures for Lossless Ion Manipulations (SLIM); Sandilya V B Garimella ; Yehia M Ibrahim ; Ian K Webb ; Ahmed M Hamid ; Liulin Deng ; Erin S Baker ; Xueyun Zheng ; Richard D Smith ; Pacific Northwest National Laboratory, Richland, WA WOH pm 0:50 Capillary Zone Electrophoresis-Tandem Mass Spectrometry with the Third-Generation Electro- Kinetically Pumped Sheath Flow Interface for Large-Scale Proteomics; Liangliang Sun ; Katelyn R Ludwig ; Guijie Zhu ; Amanda B. Hummon ; Norman J Dovichi ; University of Notre Dame, South Bend, IN; University of Notre Dame, Notre Dame, IN WOH pm 0:0 A Novel Sensitive Sheathless CE-MS Device for Peptide and Protein Analysis; Tam T. T. N. Nguyen ; Nickolaj J. Petersen ; Kasper D. Rand ; University of Copenhagen, Copenhagen, Denmark WOH pm 0:0 Developing an Ultra UltraHigh Pressure Liquid Chromatography (UUHPLC) system for LC-MS Based Metabolomics; Beixi Wang ; Jeremy Felton ; Paige Malec ; Stephanie Moore ; James Treadway ; Dan Lunn ; James Jorgenson ; Robert Kennedy ; University of Michigan, Ann Arbor, MI; University of North Carolina at Chapel Hill, Chapel Hill, NC WOH pm 0:50 Characterization of the Sarcomeric Proteome by Multidimensional Liquid Chromatography Fractionation and Top-down High-Resolution Mass Spectrometry; Trisha Tucholski ; Wenxuan Cai, ; Andrew J Alpert, 4 ; Bifan Chen 5 ; Yutong Jin 5 ; Ying Ge, 5 ; Department of Chemistry, University of Wisconsin - Madison, Madison, WI; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI; Molecular and 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 47

48 WEDNESDAY GENERAL AFTERNOON INFORMATION ORAL SESSIONS Cellular Pharmacology Training Program, University of Wisconsin - Madison, Madison, WI; 4 PolyLC Inc., Columbia, MD; 5 Department of Chemistry, University of Wisconsin-Madison, Madison, WI WOH pm 04:0 Liquid Chromatography High Resolution Tandem Mass Spectrometry of Laser Ablation Sampled Tissue; Fabrizio Donnarumma ; Michael E Pettit ; Touradj Solouki ; Kermit K Murray ; Louisiana State University, Baton Rouge, LA; Baylor University, Waco, TX 4:45 5:0 PM, WEDNESDAY AFTERNOON ASMS MEETING Jenny Brodbelt, ASMS President, presiding Enjoy a beverage and hear the latest ASMS news. Stars Ballroom, level 5:45-7:00 PM WEDNESDAY WORKSHOPS There are light refreshments in common areas. 0 Bioanalysis: Current Status of Strategy and Practice of a Tiered Approach (Regulated Bioanalysis Interest Group) Fabio Garofolo and Jian Wang presiding Room 0, level The workshop will review the recent development and current status of strategy and practice of tiered approach in bioanalysis. The recommendations from various bioanalytical societies and organizations such as Global Bioanalytical Consortium (GBC) and European Bioanalytical Forum (EBF) and from Crystal City Conferences will be discussed. A pre-workshop survey will be conducted among ASMS members on the tiered approach in bioanalysis. The workshop will provide an opportunity for attendees to exchange opinions, experiences, and practices with the ultimate goal of having a better understanding of how to apply a tiered approach as part of the bioanalytical strategy. 0 Large-Scale Analysis of MS Big Data: From Data to Knowledge and Back Nuno Bandeira presiding Room, level Advances in mass spectrometry instrumentation, integration with genomics/transcriptomics data and the public availability of hundreds of Terabytes of mass spectrometry data have created significant challenges for the analysis of proteomics and metabolomics data. This workshop will focus on publicly available algorithms and resources illustrating how distributed computing and mass spectrometry data repositories can be used to assist with the analysis of newly acquired data. Furthermore, we will also discuss ways to productively engage the mass spectrometry community in aggregating their contributions into a community-wide knowledge base reusable for both experimental design and continuous reanalysis towards complete annotation of public mass spectrometry data. 0 FTMS: Day-to-Day Concerns for High Resolution Mass Analysis (FTMS Interest Group) David Kilgour and Don Smith presiding Room 5A, level This year s workshop will be a round-table discussion focusing on dayto-day considerations for optimum FTMS operation and data collection. A poll will be taken prior to the workshop to determine the most popular discussion points. In addition, there will be an open discussion on any other points of interest. What are the major opportunities to make the next generation of FTMS instruments better than the current ones? What are the most common day-to-day struggles that FTMS users encounter? Worried about mass calibration or mass errors? Bad or variable sensitivity? Instrument maintenance? Data processing and confidence in results? There are many more besides these. But, which are the most important to us as a community and can we use this information to shape our own future? Our aim will be to identify those key priority areas which might inform future programs for improving the capabilities offered by FTMS instrumentation. 04 Novel Mass Spectrometry Instrumentation: Moving into the Hands of Practitioners (Forensics & Homeland Security Interest Group) Guido Verbeck presiding Room 5B, level Researchers are pushing the limits on trace forensic analysis and novel sampling techniques. They are also making mass spectrometry (MS) portable and durable for direct field applications; not just gas inlet, but liquid and solid sampling also. Recent developments in portable mass spectrometry present several interesting questions for workshop attendees to discuss. Questions for discussion include; Is it possible to create a reliable analytical tool that is red light - green light? Can portable MS become a tool that first responders can use without the need for extensive training? Will portable MS be considered a screening or a confirmatory method of analysis (e.g. by SWGDRUG) or will the error rates be measured (e.g. to meet Daubert requirements). How readily will portable MS be admissible in court? Could on-site measurements influence the way the criminal justice system operates and thereby save money? Here we will explore these issues, and have a series of presentations that include portable MS developers and representatives from the practitioner/law enforcement perspectives. We will explore the courtroom, and what burden-of-proof is laid at the feet of the tool developer. A discussion will be moderated about moving portable MS forward as the presumptive test, as well as the prosecutorial final test. 05 Photoionization: New Developments (Photoionization MS Interest Group) Jack Syage and Ralf Zimmermann presiding Room 5C, level This will be the fourth year for a Photoionization (PI) workshop. Previous ones were very successful with strong turnout and varied and vigorous discussions. There are two flavors of photoionization currently being practiced today: () atmospheric pressure photoionization (APPI) is a commercial technology and practiced mostly on LC/MS instrumentation though there are vibrant growing new applications in direct ambient analysis, GC/MS and direct vapor (or vaporized) sample analysis. () Vacuum photoionization more commonly referred to as single-photon ionization (SPI) involves VUV light sources including lasers that ionize sample inside the vacuum chamber and is more of a research tool for studying spectroscopic properties of molecules, but also finding powerful applications in air monitoring particularly pollutant monitoring such as vehicle or flue exhaust. In this fourth year we will focus on new applications. APPI and PI are finding unique uses in high volume applications, most specifically explosives detection in security environments for its unique benefits that are not provided by competing ionization methods. PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

49 5:45-7:00 PM WEDNESDAY WORKSHOPS 06 The NIH Review and Funding Process Charles Edmonds, Salvatore Sechi, and Douglas Sheeley presiding Room 5D, level A major source of financial support for many ASMS members and participants is the National Institutes of Health. During this workshop the general funding and review process of grant proposals will be presented. Issues like identifying the best NIH contact, writing an effective application, and responding to the reviewers criticisms will be discussed. Speakers will explore these issues from the perspectives of the applicant, reviewer, and administrator, with some emphasis on new investigators and training opportunities. A mock NIH study section presentation will provide additional insight into the review process and opportunity for discussion with NIH staff. Substantial time will be allotted for discussion and questions. 07 Entrepreneurship: Creating a Job in Mass Spectrometry Alexandre Shvartsburg presiding Room 0A, level Much of the employment growth and technological advance in North America has lately come from start-ups. While spectacular successes of young companies in the IT and new media arena are widely covered and acclaimed, the entrepreneurial opportunities in other hi-tech areas are much less known. In mass spectrometry, start-ups have hugely contributed to the maturation of novel instrumentation and methods that define the frontline of our field and provided exciting and gainful employment for many analytical chemists including recent graduates. This new ASMS workshop will focus on the key strategies and processes to create successful businesses leveraging the rapid development of MS technology and associated expansion of bioanalytical and environmental applications, and raise the awareness in broad ASMS community about entrepreneurship as a viable career path. The program would feature brief presentations by a diverse group of academic and industrial scientists who have launched prosperous ventures involving MS within the last two decades. Speakers will focus on key aspects of establishing a start-up in the field, such as funding, marketing, securing and protecting the intellectual property, licensing, staff hiring, manufacturing options, and relationships with major vendors. The workshop will conclude in a panel discussion with questions from the audience. 08 Protein Quantitation (Absolute) by LC-MS: Biomarker and Biotherapeutic Dawn Dufield and Nalini Sadagopan presiding Room 0BC, level With increase in focus on biologic/biotherapeutic drugs by the pharmaceutical industry and also an increase in need for biomarkers (efficacy and safety) the deployment of LC-MS based techniques is on the rise primarily due to the speed in method development, and specificity of the technique. Scientists are finding new ways of doing sample prep to increase sensitivity/specificity, address reproducibility issues associated with enzymatic digestion and mass spectrometric methods to address specificity. The forum will provide a platform to share common themes, issues on these fronts and perhaps to surface newer needs in software, mass spec design, and automation. 09 Isomeric Glycans: Characterization & Quantitation Yehia Mechref presiding Room 0A, level Glycosylation of proteins is one of the most common protein posttranslational modifications (PTM). A correlation between changes in the glycan moieties of glycoproteins and many mammalian diseases, including hereditary disorders, immune deficiencies, cardiovascular disease, and cancer has been suggested. The diverse biological roles of glycans and their implications in diseases have created a demand for reliable glycomic strategies, permitting sensitive monitoring of isomeric glycans in biological systems. These strategies are needed to better understand the roles and attributes of glycan in biological systems. In this workshop, the use of different MS/MS and LC-MS/MS strategies for the compressive characterization of glycan isomers will be critically described and discussed. These strategies employ several separation and mass spectrometric techniques, including liquid chromatography (different modes), matrix-assisted laser desorption ionizationmass spectrometry (MALDI-MS), and electrospray ionization-mass spectrometry (ESI-MS). 0 Protein Therapeutics: Characterization using MS (Biotherapeutics Interest Group) Damian Houde and Ashley Ruth presiding Room 0BC, level This workshop will be a forum to discuss the current technical challenges and solutions for the characterization of protein therapeutics by mass spectrometry. Mass spectrometry is now used for protein characterization from discovery through product development. The workshop will begin with a discussion of hot topics identified at this year s Sanibel Conference on Protein Therapeutic Characterization. This may include a variety of topics, ranging from protein modifications, higher-order structure characterization, protein batch comparability and biosimilarity, or protein production lot release to initiate a discussion. Recent advancements in instrumentation and software for data analysis and reporting may also be discussed. The Exposome: MS-based Metabolomic Workflows to Characterize the Exposome (Exposomics Interest Group) Anthony Macherone presiding Room 0A, level The exposome compliments the genome and integrates genetic information with non-genetic exposures and the associated biological response pathways in the search for causative factors of chronic human disease. Within the exposome paradigm, the internal environment is composed of all bio-active chemicals circulating in the body regardless of their origin e.g. genetically derived or exposure derived. Examples include dietary chemicals, drugs, persistent organic pollutants, bio-transformation products (metabolites), foreign DNA, reactive electrophiles adducted to human serum albumin and other sources of exposure (e.g., noise pollution, place of residence, lifestyle choices, etc.) that stimulate biochemical responses. Exposomics is the application of omics-based tools such as NMR, mass spectrometry and bioinformatics to characterize and measure the exposome and applies the tools of systems biology in a truly multiplatform, multi-omics approach. Mass spectrometric workflows in metabolomics and the bioinformatics software required to interpret the resulting data, provide an excellent model for the characterization of the exposome. This workshop will define how metabolomic procedures and workflows can be used to characterize human exposure profiles and will provide examples used to characterize the exposome. Biomarker Translation: Quality Control & Quality Assurance (Clinical Chemistry Interest Group) Timothy Garrett and Brian Rappold presiding Room 0BC, level Quality control and quality assurance (QC/QA) procedures for translating discovery assays to clinical use are poorly, if at all, defined. This workshop will offer brief topic introductions regarding the expectations of QC/QA in clinical diagnostics for multimarker assays, including algorithm based assessments. A similar dearth of QC/QA procedures is found in technologies which are highly naive to the industry, such as high resolution MS and tissue/imaging. As such, speakers from the field will introduce concepts related to QC/QA in such methodologies to enable discussion amongst the group. Hopefully, such discussion will introduce new approaches to ensuring quality in translational workflows for all attendees. 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 49

50 5:45-7:00 GENERAL PM WEDNESDAY INFORMATION WORKSHOPS Imaging MS: Present and Future of Multimodal Studies (Imaging MS Interest Group) Vilmos Kertesz and Raf Van de Plas presiding Room 04, level It is increasingly common for Imaging MS to make up part of multimodal imaging studies in which a set of different image types are brought to bear on the same or related samples. Analytical approaches that characterize a sample using different principles, measuring for example functional, chemical, as well as biological information within a single experiment, can often provide insights not available from a single modality alone. While multimodal imaging that includes a mass spectral modality has greatly advanced, different research groups have gone about such studies with widely-varying workflows and approaches. In this workshop, we want to discuss how challenges can be tackled at the sample preparation, at the instrumental, as well as at the computational level. Furthermore, we want to see whether an overall direction for the field and a set of best practices can be distilled, complemented by a list of major challenges that yet need to be tackled. The central topic of the workshop will therefore be Imaging by Mass Spectrometry as part of Multimodal Imaging Studies. The workshop proposes to examine three different aspects of multimodal imaging MS experiments:. Experimental design - How to design a good multimodal imaging MS experiment? (e.g. What modalities to acquire? How to make the collected image types synergistic and not just a simple combination?). Measurement - How to acquire the different image types? (e.g. How do you properly prepare the sample for multimodal measurements? Is it better to integrate mass spectrometry and other image type measurements into a single device? Or are we better off keeping separate instruments?. Data analysis - How can multimodal data be brought together, and what are the advantages and disadvantages of the different approaches? (e.g. What are the different strategies to handle/visualize multimodal data sets? 4 Galaxy for Proteomics Data Analysis: An Interactive Demonstration Tim Griffin presiding Room 05, level The Galaxy framework has emerged as a useful and powerful tool for MS-based proteomics data analysis and also multi-omic application (for example see recent publications such as Nat Biotechnol. 05, :7-9; Mol Cell Proteomics. 05, 4:087-9; Mol Cell Proteomics. 0, :M.05974). The Galaxy operating environment offers an informatics workbench where disparate software can be deployed and integrated into complex workflows. Galaxy also offers the ability to share complete workflows and data with other users, promoting reproducibility and dissemination of even complex data analysis schemes. This workshop will provide attendees the opportunity to take Galaxy for a test drive in analyzing MS-based protoemics data. Attendees will have the opportunity to access a Galaxy instance and walk through the basic steps of setting up an analysis of representative MS data from a proteomics experiment. The hands-on tutorial will include steps such as pre-processing of mass spectral data, sequence database searching, and filtering and visualizing outputs. Attendees will also be introduced to basic operations and concepts of the Galaxy operating environment, such as the creation of histories and workflows, and functionalities for sharing tools and workflows with others. An overview of the current state of software available in Galaxy for proteomics and multi-omics applications will also be provided. The workshop will be led by both developers and users well-versed in the use of Galaxy for multi-omics data analysis. Attendees are encouraged to bring a laptop computer to participate. AFTER 8:00 PM CORPORATE HOSPITALITY SUITES GRAND HYATT HOTEL THURSDAY MORNING ORAL SESSIONS 8:0-0:0 am Thursday New Concepts for Forensic MS Candice Bridge (National Center for Forensic Science) Hall, level ThOA am 08:0 Paper Spray Mass Spectrometry for Screening of Illicit Drugs from Blood Samples; Rachel Potter ; Nicholas Manicke ; IUPUI, Indianapolis, IN ThOA am 08:50 Comparative Study for the Authentication of Marijuana Varieties by Conventional and High- Resolution Mass Spectrometric Profiling; Xinyi Wang ; Peter B Harrington ; Steven F Baugh ; Ohio University, Athens, OH; Cannaprint, LLC, Broomfield, CO ThOA am 09:0 Coupling Ambient Ionization and In-source Collision Induced Dissociation for the Detection and Chemical Imaging of Organic and Inorganic Forensic Compounds; Thomas P. Forbes ; Edward Sisco ; National Institute of Standards and Technology, Gaithersburg, MD ThOA am 09:0 Classification of Blow Fly Eggs for Determination of Post-Mortem Interval; Justine E. Giffen ; Jennifer Y. Rosati ; Rabi A. Musah ; University at Albany - SUNY, Albany, NY; John Jay College of Criminal Justice, NY, NY; University at Albany-SUNY, Albany, NY ThOA am 09:50 Proteomics and Ancient History - Identification of Proteins from Skin and Muscle Tissue from Ancient Egyptian Mummies; Prathiba Ravishankar ; Dylan Xavier ; Fallen Kai Yik Teoh ; David C.L. Handler ; Mads Moeller Foged ; Mehdi Mirzaei ; Dong Hoon Shin ; Raffaella Bianucci 4 ; Jana Jones ; Paul A Haynes 5 ; Macquarie University, Sydney, Australia; Australian Proteome Analysis Facility, Sydney, Australia; Seoul National University, Seoul, South Korea; 4 University of Turin, Torino, Italy; 5 Macquarie University, North Ryde, Sydney, NSW ThOA am 0:0 Illuminating Lifestyles of People by Metabolomics of Personal Objects; Amina Bouslimani ; Alexey V Melnik ; Zhenjiang Zech Xu ; Amnon Amir ; Ricardo Silva, ; Mingxun Wang ; Nuno Bandeira ; Theodore Alexandrov, 4 ; Rob Knight ; Pieter Dorrestein ; UCSD, San Diego, CA; Universidade de São Paulo - USP, Sao Paulo, Brazil; EMBL Heidelberg, Heidelberg, Germany; 4 SCiLS GmbH, Bremen, Germany 8:0-0:0 am Thursday Fundamentals: Photodissociation John P. O Brien (The Dow Chemical Company) Room, level ThOB am 08:0 Diazirine Enabled Gas Phase Coupling of Pepitdes Utilizing Newly Developed Photo- Lysine Amino Acid; Robert Pepin ; Christopher L Shaffer ; Frantisek Turecek ; University of Washington, Seattle, WA PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

51 THURSDAY MORNING ORAL SESSIONS ThOB am 08:50 Conformational Specific Infrared and Ultraviolet Spectroscopy of Cold YA(D-Pro)AA H+Ions: A Stereochemical Twist on the Proline Effect; Christopher Harrilal ; Andrew DeBlase ; Nicole Burke ; Timothy Zwier ; Scott A McLuckey ; Purdue University-Department of Chemistry, West Lafayette, IN ThOB am 09:0 Examination of the Asymmetric and Symmetric Dissociation Pathways of Tetrameric Protein Complexes using 9 nm UVPD; Lindsay Morrison ; Jennifer S Brodbelt ; University of Texas at Austin, Austin, TX ThOB am 09:0 UVPD on the Benchtop Q Exactive Orbitrap Applied to Peptides, Proteins, and Protein Complexes; Kyle Fort ; Sam Tamara ; Andrey Dyachenko ; Alexander A Makarov, ; Richard Scheltema ; Albert J R Heck ; Utrecht University, Utrecht, The Netherlands; Thermo Fisher Scientific, Bremen, DE ThOB am 09:50 From the Top to the Bottom and Back: hvpd on Conformer Selected Ions Probing the Role of Co-factors of Structure; Alina Theisen ; Bin Yan ; Rodger Kutta ; Alex Jones ; Bruno Bellina ; Perdita E Barran ; The University of Manchester, Manchester, United Kingdom; The University of Manchester, Manchester, Greater Manchester ThOB am 0:0 Performance Considerations for Ultraviolet Photo-Dissociation using the Nd:YAG 5th Harmonic (nm); Chad Weisbrod ; Eugene Zhuk ; Jean-Jacques Dunyach ; Jae Schwartz ; ThermoFisher Scientific, San Jose, CA 8:0-0:0 am Thursday New Developments in Ionization and Sampling for DMPK Naidong Weng (Johnson & Johnson) Stars Ballroom, level ThOC am 08:0 Coated Blade Spray-Mass Spectrometry (CBS- MS) as a Versatile Approach for Quantitative Analysis in Small and Large Sample Volumes of Biofluids; German Augusto Gomez-Rios ; Nathaly Reyes-Garces ; Ezel Boyacı ; Justen Poole ; Janusz Pawliszyn ; University of Waterloo, Waterloo ON, Canada ThOC am 08:50 Functionalized Sampling Probe for Direct Mass Spectrometry Analysis of Lipids in Blood Samples; Wenpeng Zhang ; Zheng Ouyang ; Biomedical Engineering, Purdue University West Lafayette, IN ThOC am 09:0 Microfluidic Electrochemical Cell for Studying the Adduct Formation of Reactive Metabolites by ESI-MS; Tina Wigger, ; Floris T.G. van den Brink ; Mathieu Odijk ; Wouter Olthuis ; Albert van den Berg ; Uwe Karst, ; University of Münster, Institute of Inorganic and Analytical Chemistry, Münster, Germany; NRW Graduate School of Chemistry, Münster, Germany; University of Twente, MESA+ Institute for Nanotechnology and MIRA Institute for Biomedical Technology and Technical Medicine, BIOS Lab on a Chip group, Enschede, The Netherlands ThOC am 09:0 Effective Coupling of CE with nanoesi MS via a True Sheathless Metal-coated Emitter Interface for Robust and Sensitive Sample Quantification; Keqi Tang ; Xuejiang Guo ; Thomas Fillmore ; Yuqian Gao ; Pacific NW National Laboratory, Richland, WA; Nanjing University, Nanjing, China ThOC am 09:50 Novel Acoustic Interface for Ultra-High- Throughput Mass Spectrometry Utilizing Multiple Ambient Ionization Techniques; Ian Sinclair ; Jonathan Wingfield ; Martin Bachman ; Steven D Pringle ; Luke Ghislain 4 ; Eric Hall 4 ; Rick Stearns 4 ; Sammy Datwani 4 ; Lars Majlof 4 ; Michael Morris ; AstraZeneca, Macclesfield, UK; AstraZeneca, Cambridge, UK; Waters, Wilmslow, United Kingdom; 4 Labcyte Inc, Sunnyvale, CA - California ThOC am 0:0 Sub Second Quantitative Mass Spectrometry Analysis No Longer a Fiction with Acoustic Sample Deposition and Fiber Coupled LDTD-MS/ MS; Pierre Picard ; Jean Lacoursière ; Alex Birsan ; Serge Auger ; Phytronix Technologies, Inc. Quebec, Canada 8:0-0:0 am Thursday Translational Success with MS Ashok R. Dongre (Bristol-Myers Squibb R&D) Stars Ballroom -, level ThOD am 08:0 Pathology-driven Comprehensive Proteomic Profiling of the Prostate Cancer Tumor Microenvironment; Lisa Staunton ; Claire Tonry ; Espina Virginia ; Lance Liotta ; John O Leary ; Rosina Lis 4 ; Michaela Bowden 4 ; Finn Stephen ; Massimo Loda 4 ; Stephen Pennington 5 ; University College Dublin, Dublin, Ireland; George Mason University, Manassas, Virginia; Trinity College Dublin, Dublin, Ireland; 4 Dana Farber Cancer Institute, Boston, MA; 5 UCD Conway Institute, Dublin, Europe ThOD am 08:50 Development of a Novel Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Platform iendoscope for in vivo Chemical Histology during Colonoscopy.; James Alexander ; Louise Gildea ; Julia Balog ; Abigail Speller ; Anna Mroz ; Alasdair Scott ; James McKenzie ; Kirill Veselkov ; Robert Goldin ; James Kinross ; Jonathan Hoare ; Julian P Teare ; Zoltan Takats ; Imperial College, London, United Kingdom; Waters, Manchester, United Kingdom ThOD am 09:0 Rapid Identification of Carbapenem-resistant Klebsiella Pneumoniae using High-Resolution Tandem Mass Spectrometry; Raja Sekhar Nirujogi ; Sreelakshmi K Sreenivasamurthy ; Santosh Renuse ; Pranita J Tamma ; Patricia J Simner ; Akhilesh Pandey ; Johns Hopkins University School of Medicine, Baltimore, MD ThOD am 09:0 Ultrafast Detection of Amino-Acid Substitutions in DNA Gyrase A Related to Fluoroquinolone Resistant Typhoidal Salmonella Isolates using PRM; Robert-Jan Hassing ; Wil Goessens ; Lona Zeneyedpour ; Sadaf Sultan ; Jeroen van Kampen ; Annelies Verbon ; Perry van Genderen ; John Hayes ; Theo Luider ; Lennard Dekker ; Erasmus Medical Center, Rotterdam, The Netherlands; Havenziekenhuis, Rotterdam, The Netherlands ThOD am 09:50 A Physical and Genetic Interaction between the Cardiac Transcription Factor Tbx5 and Chromatin Remodeling Complexes is Essential for Cardiac Septation; Todd M. Greco ; Lauren Waldron ; Jeffrey D. Steimle ; Nicholas C. Gomez 4 ; Kerry M. Dorr ; Junghun Kweon ; Brenda Temple 5 ; Xinan Holly Yang ; Caralynn M. Wilczewski ; Ian J. Davis 6 ; Ivan P. Moskowitz ; Frank L. Conlon ; Ileana M. Cristea ; Princeton University, Princeton, 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

52 THURSDAY GENERAL MORNING INFORMATION ORAL SESSIONS NJ; University of North Carolina Heart Institute, UNC-Chapel Hill, Chapel Hill, NC; Departments of Pediatrics, Pathology, and Human Genetics, The University of Chicago, Chicago, IL; 4 Integrative Program for Biological and Genome Science, UNC- Chapel Hill, Chapel Hill, NC; 5 R.L. Juliano Structural Bioinformatics Core, Department of Biochemistry and Biophysics, UNC-Chapel Hill, Chapel Hill, NC; 6 Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC ThOD am 0:0 Discovery and Mechanistic Investigation of Novel Metabolic Features of Lung Cancer and Their Potentials of Clinical Applications; Hyuntae Yoo ; Tzu-Fang Lou ; Deepa Sethuraman ; Pallevi Srivastva ; John Minna ; University of Texas at Dallas, Richardson, TX; University of Texas Southwestern Medical Center, Dallas, Texas 8:0-0:0 am Thursday Glycopeptides and Glycoproteins Franklin E. Leach III (Photochem Technologies) Stars Ballroom 4, level ThOE am 08:0 Dopant Enriched Nitrogen Gas Enhances Sensitivity and Repeatability Opening New Possibilities for Glyco(proteo)mics Analysis with Sheathless CE-ESI-MS; Guinevere S.M. Kammeijer ; Isabelle Kohler ; Bas C. Jansen ; Gerda C.M. Vreeker ; Paul J. Hensbergen ; Oleg A. Mayboroda ; David Falck ; Manfred Wuhrer ; Leiden University Medical Center (LUMC), Leiden, Zuid-Holland ThOE am 08:50 Comprehensive Glycoproteomics of Glioblastoma Biospecimens; Chun Shao ; Joshua Klein ; Joanna Phillips ; Joseph Zaia ; Department of Biochemistry, School of Medicine, Boston University, Boston, MA; Department of Neurological Surgery and Pathology, University of California, San Francisco, San Francisco, CA ThOE am 09:0 Quantification of Human Cell Surface N-Glycoprotein Dynamics; Haopeng Xiao ; Ronghu Wu ; Georgia Institute of Technology, Atlanta, USA ThOE am 09:0 Isomeric Separation of Glycopeptides using Aporous Graphitic Carbon (PGC) LC-MS Platform; Rui Zhu ; Jingfu Zhao ; Aiying Yu ; Yehia Mechref ; Texas Tech University, Lubbock, Texas ThOE am 09:50 Site-directed Analysis of Unnatural Glycopeptide Variants and the Associated Glycan Structures by Semi-Targeted LC/MS and MRM Analysis; Dayoung Park ; Gege Xu ; Carlito B Lebrilla ; UC Davis, Davis, CA - California ThOE am 0:0 Quantitative Profiling of O-GlcNAc Glycosites in Human T Cells during Activation; Christina Woo ; Peder J Lund ; Sharon J Pitteri ; Mark M Davis, ; Carolyn R Bertozzi, ; Stanford University, Stanford, CA; Stanford University School of Medicine, Palo Alto CA, USA; Howard Hughes Medical Institute, Chevy Chase, MD 8:0-0:0 am Thursday Informatics: TARGETED PROTEOMICS AND DIA Hannes L. Röst (IMSB, ETH Zurich & Stanford University) Hemisfair Ballroom, level ThOF am 08:0 EncyclopeDIA: a New Algorithmic Approach to Detect, Site-Localize, And Quantify Phosphopeptide Positional Isomers from DIA Experiments; Brian C. Searle, ; Robert T Lawrence ; Michael J MacCoss ; Judit Villén ; University of Washington, Seattle, WA; Proteome Software, Portland, OR ThOF am 08:50 A Novel Framework for Spectral Assay Library Construction and Targeted Quantitative Data Extraction in Metabolomics with Data Independent Acquisition; Gengbo Chen ; Scott Walmsley ; Lei Zhou,, 4 ; Liyan Chen ; Ching-Yu Cheng, 4 ; Roger W Beuerman, 4 ; Tien-Yin Wong,,4 ; Gemmy C.M. Cheung, 4 ; Hyungwon Choi ; National University of Singapore, Singapore, Singapore; University of Colorado Denver-Anschutz In Aurora, CO, Denver, USA; Singapore Eye Research Institute, Singapore, Singapore; 4 Duke-NUS Graduate Medical School, Singapore, Singapore ThOF am 09:0 Targeted Analysis of MS Data for Quantitative Studies; Roland M. Bruderer ; Yue Xuan ; Ian Lienert ; Oliver M. Bernhardt ; Tejas Gandhi ; Lukas Reiter ; Biognosys AG, Schlieren, Switzerland; Thermo Fisher Scientific, Bremen, DE ThOF am 09:0 Benchmarking SWATH by LFQBench: a Multi- Centered Study Evaluates and Improves Data- Independent-Acquisition-Based Label Free Quantification Tools; Pedro Navarro ; Joerg Kuharev ; Ludovic C Gillet ; Oliver M Bernhardt ; Brendan MacLean 4 ; Stephen Tate 5 ; Chih-Chiang Tsou 6 ; Lukas Reiter ; George Rosenberger ; Yasset Perez-Riverol 7 ; Alexey I Nesvizhskii 6 ; Ruedi Aebersold ; Stefan Tenzer ; University Medical Center of the Johannes Gutenbe, Mainz, Rheinland-Pfalz; ETH Zurich, Zürich, Switzerland; Biognosys AG, Schlieren, Switzerland; 4 University of Washington, Seattle, WA; 5 SCIEX, Concord, ON; 6 University of Michigan, Ann Arbor, MI; 7 EMBL-EBI, Hinxton, UK ThOF am 09:50 Advanced Workflows and Concepts for the Analysis of High Throughput Targeted Proteomics Experiments of Large Heterogeneous Datasets; Isabell Bludau ; George Rosenberger ; Ben Collins ; Uwe Schmidt ; Patrick Pedrioli ; Ruedi Aebersold ; Institute of Molecular Systems Biology, ETH Zurich, Zurich, CH; ID Scientific IT Services, ETH Zurich, Zurich, CH ThOF am 0:0 Detection and Quantification of Proteins in SWATH-MS Analysis without using Spectral Libraries; Stephen A Tate ; Jamie Sherman ; Pradeep Narayanaswamy ; SCIEX, Concord ON, Canada 8:0-0:0 am Thursday Application of Stable Isotope Labeling in MS Jim Edwards (Saint Louis University) Hemisfair Ballroom, level ThOG am 08:0 Quantity: An Isobaric Tag for Quantitative Glycomics; Shuwei Li ; Shuang Yang ; Meiyao Wang ; Lijun Chen ; Bojiao Yin ; Karen W Phinney 4 ; Illarion V Turko 4 ; Michael Betenbaugh ; Guoqiang Song 5 ; Chung Cheng-yu 6 ; Hui Zhang ; Center for Advanced Research, Rockville, MD; Johns Hopkins School of Medicine, Baltimore, MD; Center for Disease Control and Prevention, Atlanta, GA; 4 National Institute of Standards and Technology, Gaithersburg, MD; 5 Changzhou University, Changzhou, China; 6 Johns Hopkins University School of Medicine, Baltimore, MD ThOG am 08:50 A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics through Specific O-GlcNAc Isotopic Labeling; Xiaoshi Wang ; Zuo- Fei Yuan ; Jing Fan ; Kelly R Karch ; Lauren E Ball ; John M Denu ; Benjamin A Garcia 4 ; University of Pennsylvania School Of Medicine, Philadelphia, PA; University of Wisconsin Madison, Madison, PAGE 5 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

53 THURSDAY MORNING ORAL SESSIONS Wisconsin; Medical Univ of S Carolina, Charleston, SC; 4 University of Pennsylvania School of Medicine, Philadelphia, PA ThOG am 09:0 High-Performance Chemical Isotope Labeling LC-MS for Tracking Disease Progression: Metabolomic Study of Alzheimer s Disease in a Mouse Model; Liang Li ; Wei Han ; Kevin Hooton ; Dorothea Mung ; Keding Cheng ; Sharon Simon ; David Knox ; University of Alberta, Edmonton, Canada; Public Health Agency of Canada, Winnipeg, Canada ThOG am 09:0 An Integrated Workflow for Qualitative Flux Analysis by Accurate Mass LC/MS; Stephen Madden ; Alex Apffel ; Xinning Jiang ; Ed Darland ; Yinghang Yang ; Xiangdong Li ; Crystal Cody ; Norton Kitagawa ; Agilent Technologies, Inc., Santa Clara, CA; Agilent Technologies, Santa Clara, CA ThOG am 09:50 HAHA: A Novel Strategy for Quantification of Newly Synthesized Proteins; Yuanhui Ma ; Daniel B Mcclatchy ; John Yates ; The Scripps Research Institute, La Jolla, CA ThOG am 0:0 Just Add Water and Resolving Power: Metabolic Labeling and MS Techniques for Lipid and Intact Protein Quantitation in Any Organism; Nicholas D Schmitt ; Jeniffer Quijada ; Christopher Thompson ; Michael L Easterling ; Jeffrey Agar ; Northeastern University, Boston, MA; Bruker Daltonic, Billerica, MA 8:0-0:0 am Thursday Ion Mobility: Structure Kevin Pagel (Freie Universitaet Berlin) Hemisfair Ballroom, level ThOH am 08:0 An Ion Mobility, Molecular Dynamics, Top- Down and H/DX Study of Monoclonal Antibody Structural Collapse in the Gas-phase; Iain D G Campuzano ; Morgan Lawrenz ; Carlos Larriba- Andaluz ; Huilin Li ; Ulrik H Mistarz 4 ; Kasper Rand 4 ; Joseph Loo ; Amgen, Inc., Thousand Oaks, CA; Indiana University-Purdue University, Indianapolis, IN; UCLA, Los Angeles, CA; 4 University of Copenhagen, Copenhagen, Denmark ThOH am 08:50 Analysis of Protein Structural Changes with High Resolution Structures for Lossless Ion Manipulations (SLIM) Ion Mobility-Mass Spectrometry; Ian K. Webb ; Liulin Deng ; Ahmed M Hamid ; Gordon A Anderson, ; Randolph V Norheim ; Spencer A Prost ; Sandilya V. B. Garimella ; Erin S Baker ; Yehia M Ibrahim ; Richard D Smith ; Pacific Northwest National Laboratory, Richland, WA; Pacific Northwest National Laboratory, Richland, wa; GAA Custom Engineering, Benton City, WA ThOH am 09:0 Ubiquitin Ion Structures from the Solid State using Nothing More than a Small Molecule and Vacuum of an IMS-MS Instrument; Ellen D. Inutan, ; Tarick J. El-Baba ; Casey D. Foley ; David E. Clemmer ; Sarah Trimpin,4 ; Mindanao State University-Iligan Institute of the Technology, Iligan City, Philippines; Department of Chemistry, Wayne State University, Detroit, MI; Department of Chemistry, Indiana University, Bloomington, IN; 4 Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI ThOH am 09:0 Combining Ion Mobility with Cryogenic Ion Spectroscopy for Studying Peptide Structure on the Way from Solution to the Gas Phase; Liudmila Voronina ; Antoine Masson ; Michael Kamrath ; David E Clemmer ; Carsten Baldauf 4 ; Thomas R Rizzo ; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; UC Berkeley, Berkeley, California; Indiana University Dept. Chemistry, Bloomington, IN; 4 Fritz-Haber-Institut der Max- Planck-Gesellschaft, Berlin, Germany ThOH am 09:50 Insights from TIMS-MS, IR Spectroscopy and Molecular Dynamics on Nicotinamide Adenine Dinucleotide Structural Dynamics: NAD+vs NADH; Juan Camilo Molano ; Walter Gonzalez ; Jaroslava Miksovska ; Philippe Maitre ; Francisco Fernandez Lima ; Florida International University, Miami, FL; Laboratoire de Chimie Physique, Orsay, Orsay, France ThOH am 0:0 Polymers as Model Systems to Understand Ion Mobility Mass Spectrometry Structures in Gas Phase; Jean R. N. Haler ; Denis Morsa ; Johann Far ; Christine Jérôme ; Edwin De Pauw ; Mass Spectrometry Laboratory, University of Liege, Liege, Belgium; CERM, University of Liege, Liege, Belgium 0:0 AM :0 PM, THURSDAY THURSDAY POSTER SESSION Poster/Exhibit Hall Lunch concessions are open :00 am :00 pm Odd-number posters present 0:0 am - :00 pm Even-number posters present :00 - :0 pm THURSDAY AFTERNOON ORAL SESSIONS :0-4:0 pm Thursday Food Safety and Chemistry: Non-targeted screening Juan F. García-Reyes (University of Jaen) Hall, level ThOA pm 0:0 Comprehensive Pesticide Screening in Complex Matrices by Collision Cross Section using a Novel Geometry Travelling-Wave IMS-QTof Mass Spectrometer; Olivier Saperas ; Brigitte Ogundeji ; Jennifer Unsworth ; Nick Tomczyk ; Martin Palmer ; Darren Hewitt ; Christophe Siroit ; Davy Petit ; Daniel J. Weston ; Lacapa, Toulouges, France; Waters, Wilmslow, United Kingdom ThOA pm 0:50 Main Challenges in LC-HRAMS Method Development for Pesticide Residue Analysis; Łukasz Rajski ; María del Mar Gómez Ramos ; Amadeo R Fernández-Alba ; Maciej P Bromirski ; European Union Reference Laboratory for Pesticide Residues in Fruit & Vegetables. University of Almeria, Agrifood Campus of International Excellence (ceia)., Almeria, Spain; Thermo Fisher Scientific, San Jose CA, CA - California ThOA pm 0:0 Characterization of Iodine Containing Disinfection By-Products in Water using Gas Chromatography Orbitrap-based Mass Spectrometry.; Cristina Postigo ; Cristian Cojocariu ; Susan D Richardson ; Damia Barcelo 4 ; Paul Silcock ; Institute for Environmental Assessment and Water Research - Spanish National Research Council (IDAEA-CSIC), Barcelona, Spain; Thermo Fisher Scientific, Runcorn, UK, Runcorn, UK; University of South Carolina, Columbia, SC; 4 ICRA, Girona, Spain ThOA pm 0:0 GC x GC x Q-TOF-MS Survey of Essential Oils; Edward Ledford ; Zhanpin Wu ; Sofia Nieto ; Stephen E Reichenbach 4 ; Qingping Tao 5 ; Zoex Corporation, Houston, TX; Zoex Corporation, Lincoln, NE; Agilent Technologies, Santa Clara, CA; 4 Dep. of Computer Science and Engineering, University of Nebraska at Lincoln, Lincoln, NE; 5 GC Image, LLC Lincoln, NE 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

54 THURSDAY GENERAL AFTERNOON INFORMATION ORAL SESSIONS ThOA pm 0:50 Instantaneous Determination of Cocoa Content and Cocoa Bean origin of Commercial Products with Rapid Evaporative Ionization Mass Spectrometry; Julia Balog, ; Richard Schäffer ; Tamas Juhasz ; Tamas Karancsi ; Steven D Pringle ; Zoltan Takats ; Waters Research Centre, Budapest, Hungary; Imperial College London, London, United Kingdom; Waters, Wilmslow, United Kingdom ThOA pm 04:0 Classification of Olive Oils using Direct Analysis Atmospheric Pressure Chemical Ionization- Mass Spectrometry; Pilar Perez-Hurtado ; Amy Giles ; Mark Allen ; Lourdes Arce ; Matthew Turner ; Jim Reynolds 4 ; Loughborough University, Loughborough, United Kingdom; Advion UK Ltd, Essex, United Kingdom; Universidad de Cordoba, Cordoba, SPAIN; 4 Loughborough University, Loughborough, Leicestershire :0-4:0 pm Thursday Fundamentals: Ion Activation and Dissociation Arpad Somogyi (The Ohio State University) Room, level ThOB pm 0:0 Charge Transfer Dissociation (CTD): High Energy Radical Fragmentation of Glycans, Peptides and Lipids; Glen Paul Jackson ; Iris Kreft ; Pengfei Li ; David Ropartz ; Hélène Rogniaux ; West Virginia University, Morgantown, WV; INRA, UR68 Biopolymers Interactions Assemblies Nantes, France ThOB pm 0:50 Improvement of Hydrogen Attachment/ Abstraction Dissociation (HAD) Efficiency for Low-Charged Peptides using Supplemental Activation; Hidenori TakahashI ; Sadanori Sekiya ; Takashi Nishikaze ; Shosei Yamauchi ; Shinichi Iwamoto ; Motoi Wada ; Koichi Tanaka ; Shimadzu Corporation, Kyoto, Japan; Doshisha University, Kyotanabe, Japan ThOB pm 0:0 Conformational Effects on the Dissociation Kinetics of Proton-Bound Heterodimer Ions: Applications to Gas-Phase Acidities of Alkanols; Kent M. Ervin ; Jerry G Lanorio ; Surja B Ghale ; Alex A Nickel ; University of Nevada, Reno, Reno, NV; University of Nevada, Reno Reno, NV ThOB pm 0:0 Mobile C-H Protons in a Proton Deficient Peptide; Damodar Koirala ; Paul G Wenthold ; Purdue University, West lafayette, IN; Purdue University, West Lafayette, IN ThOB pm 0:50 Tandem MS of Synthetic Nanoparticles through Analysis of Metastable Fragments using MALDI- TOF MS with Superconducting Tunnel Junction Cryodetection; Logan D Plath ; Chenjie Zeng ; Yuxiang Chen ; Rongchao Jin ; Mark E Bier ; Carnegie Mellon University, Pittsburgh, PA ThOB pm 04:0 Ultraviolet Photodissociation in a Full-Featured Proteomics Search Engine; Christopher Becker ; Yong J Kil ; Marshall W. Bern ; Sylvester M Greer ; Jennifer S Brodbelt ; Protein Metrics, San Carlos, CA; University of Texas at Austin, Austin, TX :0-4:0 pm Thursday MS Solutions for Drug Metabolism Challenges Yang Yuan (Dupont Crop Protection) Stars Ballroom, level ThOC pm 0:0 Direct and Accurate Quantitation of Labeled and Un-labeled Ion Species from High Resolution LC/MS Data; Peter L Wang ; Dawei Zhou ; Xinping Fang ; MING GU ; Yongdong Wang ; Jeff S. Andrews ; XenoBiotic Laboratories, Inc. WuXi AppTec Inc Plainsboro, NJ; Cerno Bioscience, Yardley, PA; Cerno Bioscience, Norwalk, CT ThOC pm 0:50 Understanding the Metabolism of Protein and Peptide Therapeutics by Developing a Top-Down Protein Metabolite Identification Platform; Xiang Yu ; Arthur Fridman ; Kristen A Kwasnjuk ; Ping Lu ; Zhiling Li ; Sherrie Xu ; Ansu Bagchi ; Mark T Cancilla ; Merck & Co., West Point, PA ThOC pm 0:0 Utilizing Tandem Mass Spectrometry for the Identification of Primary and Secondary Sulfonamide Functionalities in Protonated Analytes via Ion/Molecule Reactions; John Kong ; Ravikiran Yerabolu ; Huaming Sheng ; Weijuan Tang ; Raghavendhar Kotha ; Chungang Gu ; Hilkka Kenttämaa ; Purdue University, West Lafayette, IN; AstraZeneca, Boston, MA ThOC pm 0:0 Software Aided Integrated Workflow for Identification of Metabolic Soft-spots of Macromolecular Peptides in Drug Discovery; Asoka Ranasinghe ; Serhiy Hnatyshyn ; Eugene Ciccimaro ; Celia D Arienzo ; Timothy Olah ; Marshall M Siegel ; Gary Walker ; Bristol-Myers Squibb Company, Princeton, NJ; MS Mass Spec Consultants, Fair Lawn, NJ ThOC pm 0:50 Toward Intact Protein Mass Spectrometry for Metabolism, Pharmacokinetic, and Toxicokinetic Study Support: Immunocapture LC-MS Methods for AlbudAb and mab Biotherapeutics; John Kellie; GSK, King of Prussia, PA ThOC pm 04:0 Novel and Widely-Applicable Platform to Uncover Pharmacologically Active Metabolites Using Metabolic Biotransformation, Affinity Selection-Mass Spectrometry, and D NMR Technique; Xianshu Yang ; Ian W Knemeyer ; Chad Chamberlin ; Peter J Dandliker ; Ting Zhang ; Yong Liu ; Gary E Martin ; Huifang Yao ; Jackie Shang ; Randal M Bugianesi ; Kenneth P Ellsworth ; Lisa M Sonatore ; Peter Nizner ; Edward C Sherer ; Susan E Hill ; Wayne M Geissler ; Roy Helmy ; Harold B Wood ; Merck & Co., Boston, MA; Merck, Darmstadt, Germany; Merck & Co, Kenilworth, NJ :0-4:0 pm Thursday Ambient Ionization: Instrumentation & Applications Nicholas Brunelli (The Ohio State University) Stars Ballroom -, level ThOD pm 0:0 Coupling Electrochemistry with Probe Electrospray Ionization Mass Spectrometry (PESI-MS); Yi Cai ; Hao Chen ; Ohio University, Athens, OH ThOD pm 0:50 Fundamental Studies of Inlet Ionization with Sample Introduction at Atmospheric Pressure; Sarah Trimpin ; Stephan Rauschenbach ; I-Chung Lu ; Casey Foley ; Wayne State University, Detroit, MI; Max-Planck-Institute for Solid State Research, Stuttgart, Germany; Wayne State University, Detroit, MI ThOD pm 0:0 Successful Direct SPME-DBDI Coupling for Rapid, Ultrasensitive and Non-Chromatographic Analysis of Pesticides and Illicit Drugs in Complex Matrices; Mario Francesco Mirabelli ; Emanuela Gionfriddo ; Janusz Pawliszyn ; Renato Zenobi ; ETH Zurich, Zürich, Switzerland; University of Waterloo, Waterloo ON, Canada ThOD pm 0:0 Direct Biofluid Analysis using Hydrophobic Paper Spray Mass Spectrometry; Deidre Damon ; Abraham Badu-Tawiah ; The Ohio State University, Columbus, OH; The Ohio State University, Columbus, Ohio PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

55 THURSDAY AFTERNOON ORAL SESSIONS ThOD pm 0:50 Back to Basics - Redesigning the DESI Sprayer for Optimal Performance in Biological Tissue Imaging; Jocelyn Tillner ; James McKenzie ; Emrys A Jones, ; Steven D Pringle ; Tamas Karancsi ; Anna Mroz ; Dipa Gurung ; Josephine Bunch ; Ian Gilmore ; Zoltan Takats ; Imperial College, London, United Kingdom; Waters, Manchester, United Kingdom; National Physical Laboratory, Teddington, United Kingdom ThOD pm 04:0 Fast SAWN MS Assay for Art Restoration and Conservationstudies; Garry Corthals ; Alina Astefanei ; Petra J Jansen ; Maarten R van Bommel ; Erik Nilsson ; Gloria Yen ; University of Amsterdam, Amsterdam, ZH; University of Amsterdam, Amsterdam, The Netherlands; Deurion LLC, Seattle, WA :0-4:0 pm Thursday Biomarkers: Quantitative Analysis Matthew M. Champion (University of Notre Dame) Stars Ballroom 4, level ThOE pm 0:0 Disrupted Stoichiometric Relationships as Biomarkers of Altered Cellular States; Marija Buljan ; Tiannan Guo ; Qing Zhong ; Ulrich Wagner ; Li Li ; Andreas Beyer ; Peter Wild ; Ruedi Aebersold ; Institute of Molecular Systems Biology ETH Zurich, Zurich, Switzerland; Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland; University of Cologne, Cologne, Germany ThOE pm 0:50 Understanding Biological Heterogeneity through Mass Cytometry; Jennifer Frahm ; Christina Loh ; Tad George ; Mark Konrad ; Olga Ornastsky ; Daniel Majonis ; Andrei Terekidi ; Gary Impey ; Fluidigm Corporation, South San Francisco, CA USA; Fluidigm Canada Inc., Markham, CANADA ThOE pm 0:0 Antibody-Independent, Deep-Dive Targeted Quantification of Proteins at Ten Picogram per Milliliter Levels in Non-Depleted Human Serum/ Plasma; Song Nie ; Tujin Shi ; Thomas Fillmore ; Yuqian Gao ; Athena A Shepmoes ; Heather Brewer ; Wei-jun Qian ; Karin D Rodland ; Richard D Smith ; Tao Liu ; Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA ThOE pm 0:0 Mass Spectrometry Based Identification and Quantitation of Maturation Stage Specific Surface Markers of Human Stem Cell Derived Cardiomyocytes; Matthew Waas ; Erin Kropp ; Alyssa Nycz ; Chelsea Fujinaka ; Rebekah Gundry ; Medical College of Wisconsin, Milwaukee, WI ThOE pm 0:50 Discovery and Quantitative Metabolomics to Characterize Metabolites of Bacterial Origin as Biomarkers for Cystic Fibrosis; Jace W Jones ; Angela Nguyen ; Bennett Giardina ; Luke Brewer ; Angela Wilks ; Amanda Oglesby-Sherrouse ; Maureen Kane ; University of Maryland, School of Pharmacy Baltimore, MD ThOE pm 04:0 Quantifying Concentrations of Molecules in Live Single Cells using the Single-probe MS Technique; Ning Pan ; Wei Rao ; Haiqing Yu ; Naga Rama Kothapalli ; Mei Sun ; Anthony Burgett ; Zhibo Yang ; University of Oklahoma, Dept. of Chem & Biochem Norman, OK :0-4:0 pm Thursday Informatics: Peptide and Protein Identification Natalie Castellana (Digital Proteomics LLC) Hemisfair Ballroom, level ThOF pm 0:0 A Graph-based Method for Proteoform Identification and Quantification by Top-down Multiplexed Tandem Mass Spectra; Zhu Kaiyuan ; Xiaowen Liu ; Indiana University, Bloomington, IN; Indianapolis, IN ThOF pm 0:50 High Quality Estimation of False Discovery Rate for Proteoform Identification with Top Down Proteomics; Richard Leduc ; Daniel Shams, ; Ryan T Fellers ; Bryan Early ; Joseph Greer ; David Schwab ; Neil L Kelleher, 4, 5, 6 ; Proteomics Center of Excellence, Northwestern University, Evanston, IL; Interdisciplinary Biological Sciences, Northwestern University, Evanston, IL; Department of Physics and Astronomy, Northwestern University, Evanston, IL; 4 Chemistry of Life Processes Institute, Northwestern University, Evanston, IL; 5 Department of Chemistry, Northwestern University, Evanston, IL; 6 Department of Molecular Biosciences, Northwestern University, Evanston, IL ThOF pm 0:0 Open-pNovo: de novo Peptide Sequencing with Thousands Types of Protein Modifications; Hao Yang ; Hao Chi ; Wen-Jing Zhou ; Wen-Feng Zeng ; Kun He ; Chao Liu ; Rui-Xiang Sun ; Si-Min He ; Institute of Computing Technology, CAS, Beijing, China ThOF pm 0:0 Optimized Open Modification Spectral Library Searching using Approximate Nearest Neighbor Techniques; Wout Bittremieux ; Dirk Valkenborg ; Kris Laukens ; University of Antwerp, Antwerp; VITO, Mol, Belgium; University of Antwerp, Antwerp, Belgium ThOF pm 0:50 Sifting through Swarms of Spectra: Lessons Learned Identifying Proteins across,78 Affinity-Purification Mass Spectrometry Analyses; Edward L. Huttlin ; Joao A Paulo ; Raphael J. Bruckner ; Lily Ting ; Wade Harper ; Steven P Gygi ; Harvard Medical School, Boston, MA ThOF pm 04:0 Building Comprehensive Peptide Spectral Libraries at Repository Scale; Mingxun Wang ; Jian Wang ; Anne-Claude Gingras ; Nuno Bandeira ; UCSD, San Diego, CA; Lunenfeld Tanenbaum Research Institute, Toronto, Canada :0-4:0 pm Thursday Lipidomics: New MS Technologies and Applications Daniel Amador-Noguez (University of Wisconsin-Madison) Hemisfair Ballroom, level ThOG pm 0:0 A Quantitative Positive/Negative Ion Switching Method for Shotgun Lipidomics via High Resolution LC-MS/MS from any Biological Source; Min Yuan ; Ying Xu ; Susanne Breitkopf ; Stephane Ricoult ; John M Asara ; Beth Israel Deaconess Medical Center, Boston, MA; Harvard School of Public Health, Boston, MA ThOG pm 0:50 Lipidomic Imaging with a New Hybrid D SIMS Molecular Imaging Instrument; Melissa K PassarellI ; Alexander Pirkl ; Rudolf Moellers ; Ewald Niehuis ; Alexander A Makarov ; Henrik Arlinghaus ; Rasmus Havelund ; Paulina Rakowska ; Alan Race ; Alex Shard ; Andy West 4 ; Stevan Horning ; Peter Marshall 4 ; Morgan Alexander 5 ; Colin Dollery 4 ; Ian Gilmore ; National Physical Laboratory, Teddington, United Kingdom; ION-TOF GmbH, Munster, Germany; Thermo Fisher Scientific, Bremen, DE; 4 GlaxoSmithKline, Stevenage, UK; 5 University of Nottingham, Nottingham, UK 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 55

56 THURSDAY GENERAL AFTERNOON INFORMATION ORAL SESSIONS ThOG pm 0:0 Electron-induced Dissociation (EID) of Lipids: Diagnostic Product Ions for Confident Identification of Isomers; Jace W. Jones ; Claire Louise Carter ; Maureen A Kane ; University of Maryland, School of Pharmacy Baltimore, MD ThOG pm 0:0 Broad Characterization of Isomeric Lipids by High-Resolution Differential Ion Mobility Separations with Tandem Mass Spectrometry; Rinat R Abzalimov ; Andrew Bowman ; Alexandre A Shvartsburg ; City University of New York - Advanced Science Research Center, New York City, NY; Wichita State University, Wichita, KS ThOG pm 0:50 Nano-DESI Imaging of Lipids and Metabolites in Developing Lung; Son N. Nguyen ; Ryan L Sontag ; Jennifer E Kyle ; Sydney E Dautel ; Thomas O Metz ; Richard A Corley ; Charles K Ansong ; Mathew Thomas ; James Carson ; Julia Laskin ; Pacific Northwest National Laboratory, Richland, WA; University of Texas at Austin, Austin, TX ThOG pm 04:0 In depth Sphingomyelin and Triacylglycerol Structure Identification using Electron Impact Excitation of Ions from Organics (EIEIO) and Mass Spectrometry; Takashi Baba ; Larry J Campbell ; Yves J C LeBlanc ; Paul RS Baker ; SCIEX, Concord ON, Canada; SCIEX, Redwood City, CA :0-4:0 pm Thursday Hydrogen-Deuterium Exchange MS Sheena D Arcy (University of Texas at Dallas) Hemisfair Ballroom, level ThOH pm 0:0 HX-MS Epitope Mapping of a Ricin Toxin Chain A Double Mutant (RTA*); Ronald Toth ; Siva Krishna Angalakurthi ; John Hickey ; Sangeeta Joshi ; Charles Russell Middaugh ; Greta Van Slyke ; Nicholas Mantis, ; David Volkin ; David Weis 4 ; Department of Pharmaceutical Chemistry and Macromolecule and Vaccine Stabilization Center; University of Kansas, Lawrence, KS; Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY; Department of Biomedical Sciences, University at Albany School of Public Health, Albany, NY; 4 Department of Chemistry and R. N. Adams Institute for Bioanalytical Chemistry; University of Kansas, Lawrence, KS ThOH pm 0:50 The Role of Conformational Dynamics in Differing Activity and Substrate Specificity amongst Isozymes; Andrew Fairman ; Peter Sidhu ; David Josephy ; Derek Wilson ; York University, Toronto, Canada; University of Guelph, Guelph, Canada ThOH pm 0:0 Structural basis for the formation and function of the complement effector protein icb; Malvina Papanastasiou ; Sophia Koutsogiannaki ; Yiannis Sarigiannis ; Daniel Ricklin ; John D. Lambris ; Dept. Pathology & Lab. Medicine, Perelman School of Medicine, UPENN, Philadelphia, PA ThOH pm 0:0 A New Automation Platform Provides Significant Improvements in Both the Capacity and Flexibility of the HDX-MS Experiment; Ruben Haro ; Alfonso Espada ; Manuel Molina-Martin ; Jesus Castanon ; Bruce D Pascal ; Pat Griffin ; Jeffrey A Dodge ; Michael Chalmers ; Eli Lilly and Company, Alcobendas, SPAIN; The Scripps Research Institute, Jupiter, Fl; Eli Lilly and Company, Indianapolis, IN ThOH pm 0:50 Intramolecular Interactions in Heme Oxygenase in the Presence and Absence of Lipid Membranes; Brent A Kochert ; Angela S Fleischhacker ; Stephen W Ragsdale ; John R Engen ; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA; Department of Chemistry, University of Michigan, Ann Arbor, MI ThOH pm 04:0 The Analytical Potential of HDXMS in Providing Localized Structural Dynamics Insight to Each Subunits of an Asymmetric Non-Crystallizable Protein Homodimer; Morten Beck Trelle ; Alice Østergaard ; Jeppe Buur Madsen ; Shona Pedersen ; Søren Risom Kristensen ; Thomas J.D. Jørgensen ; University of Southern Denmark, Odense, Denmark; Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark, Ålborg, Denmark 4:45-5:00 PM PLENARY LECTURE Vicki Wysocki (The Ohio State University) presiding Hall, level More than the Sum of its Parts: Collective Phenomena in Living Systems, from Single Molecules to Flocks of Birds William Bialek Princeton University 6:0 9:00 PM, THURSDAY CLOSING EVENT BRISCOE WESTERN ART MUSEUM Ticket is required. PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

57 POSTER OVERVIEW ODD-NUMBERED POSTERS PRESENT 0:0 AM - :00 PM. EVEN-NUMBERED POSTERS PRESENT :00 - :0 PM. MONDAY POSTERS Set up all Monday posters...7:0 8:00 am Odd-numbered posters present...0:0 am :00 pm Even-numbered posters present...:00 :0 pm Remove all Monday posters...7:0 8:00 pm Antibodies & Antibody Drug Conjugates (Intact and Characterization) Biomolecular Structure Analysis: Covalent Labeling and Related Software Carbohydrates Data Independent Acquisition Diagnostic Clinical Chemistry (Applications) Drug and Metabolite Analysis: Novel Approaches for Dried Biological Samples Energy: Hydrocarbon and Petrochemical (Ultra Hi Res) Environmental Analysis: General (Part ) Environmental Analysis: Pharmaceuticals and Pesticides Epigenetic Modifications High Mass Accuracy/High Performance MS Applications Imaging MS: Instrumentation... - Imaging MS: Sample Preparation Imaging MS: Software Informatics: Metabolomics Informatics: Multiomics Integration Instrumentation: New Concepts Intact Proteins Ion Activation/Dissociation Ion Mobility: Applications (Other/Instrumentation) Ion Molecule, Ion/Ion, Ion/Electron Interactions Ion Spectroscopy LC-MS: Chromatography and Software (Part ) Lipids: General Metabolomics: General Microorganisms: Identification and Characterization Phosphopeptides: Enrichment Methods Polymers Proteins: General and Membrane Proteins: PTMs (Part ) Proteomics: Clinical Applications (Applied Proteomics) Proteomics: Quantitative Small Molecules: Qualitative Analysis Systems Biology (Multiomics and Other) Top Down Protein Analysis (Applications) TUESDAY POSTERS Set up all Tuesday posters...7:0 8:00 am Odd-numbered posters present...0:0 am :00 pm Even-numbered posters present...:00 :0 pm Remove all Tuesday posters...7:0 8:00 pm Antibodies & Antibody Drug Conjugates (Separations) Biomarkers: Quantitative Analysis (Part ) Biomolecular Structure Analysis: Chemical Crosslinking and Covalent Labeling (Cross-Linking) Data Independent Acquisition (SWATH) Diagnostic Clinical Chemistry (General) Drug Discovery/DMPK/ADME (Applications) Drug Metabolism: Qualitative and High Throughghput Analysis Energy: Hydrocarbon & Petrochemical (Hi Res and Nominal) Environmental Analysis: General (Part ) FAIMS and DMS Food Safety (Pesticides in Food) Food omics MS Characterization of Food and Nutritional Supplements (Part ) Forensics (Part ) Glycoproteins High Mass Accuracy/High Performance MS Methods and Developments Imaging MS: Disease Markers Imaging MS: Pharmaceutical Applications Informatics: Peptide ID and Quantification Instrumentation: General Instrumentation: New Developments in Mass Analyzers Ion Mobility: Applications (Proteins & Peptides) LC-MS: Chromatography and Software (Part ) Lipids: ID and Structural Analysis Metabolomics: Sample Preparation Metabolomics: Untargeted Metabolite Profiling (Cells/Plants) Nucleic Acids Peptides: PTM Identification Phosphopeptides: Quantitative Analysis Proteins: Complexes/Non-covalent Interactions Proteomics: Clinical Applications (Development toward Clinical Application) Proteomics: Infectious Diseases Proteomics: Quantitative (Application Biological Research) Small Molecules: Quantitative Analysis (Animal, Plant/Insect, and Methodology)... TP Top Down Protein Analysis (Methodology)... TP TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 57

58 GENERAL POSTER OVERVIEW INFORMATION ODD-NUMBERED POSTERS PRESENT 0:0 AM - :00 PM. EVEN-NUMBERED POSTERS PRESENT :0 - :0 PM. WEDNESDAY POSTERS Set up all Wednesday posters...7:0 8:00 am Odd-numbered posters present...0:0 am :00 pm Even-numbered posters present...:00 :0 pm Remove all Wednesday posters...7:0 8:00 pm Ambient Ionization: Fundamentals and Instrumentation (Probes, Paper Spray, DESI/ESI, Tissue/Tools) Antibodies & Antibody Drug Conjugates (Sequencing, Modifications & Hi Res) Biomarkers: Discovery (Part ) Biomarkers: Quantitative Analysis (Part ) Carbohydrates (Glycans) Disease Biomarkers Drug Discovery/DMPK/ADME (General) Energy: Biofuels and Algae Environmental Analysis: Water Quality Food Safety: Other Contaminants (Part ) Food omics MS Characterization of Food and Nutritional Supplements (Part ) Forensics (Part ) GCMS: Instrumentation and Applications (Instrumentation-New Developments) Glycoproteins (Tandem MS, Separations, and Automation/Software) H/D Exchange: Hardware, Software and Methodology H/D Exchange: Protein Structure/Function (Part ) ICP and Isotope Ratio MS: Elemental Imaging MS: Method Development (DESI/SIMS/Misc) Informatics: Algorithms and Statistical Advances Informatics: Workflow and Data Management Instrumentation: Mini/Portable/Fieldable MS Instrumentation: New Developments in Ionization and Sampling (Sampling) Ion Mobility: Fundamentals Ion Structure/Energetics LC-MS: Sample Preparation (Part ) Lipids: Profile Analysis Metabolomics: Clinical Applications Metabolomics: Untargeted Metabolite Profiling (Animal/Human/Other) Nanoscale and Microfluidic Separations and MS Plant omics Protein Therapeutics: Quantitative Analysis Proteomics: New Approaches (Global) Proteomics: Quantitative (Labeling/Tagging/MS/ Quantitation) Small Molecules: Quantitative Analysis (Part ) THURSDAY POSTERS Set up all Thursday posters...7:0 8:00 am Odd-numbered posters present...0:0 am :00 pm Even-numbered posters present...:00 :0 pm Remove all Thursday posters...:0 :00 pm Ambient Ionization: Fundamentals and Instrumentation (Dart/Plasma, Laser, SAWN) Biomarkers: Discovery (Part ) Biomarkers: Quantitative Analysis (Small Molecules & Metabolites) Drug Metabolism: Quantitative Analysis Food Safety: Other Contaminants (Part ) GCMS: Instrumentation and Applications (Applications) H/D Exchange: Protein Structure/Function (Part ) Imaging MS: Method Development (MALDI) Imaging MS: Small Molecules Informatics: General, SRM, and DIA Informatics: Protein ID and Quantification Instrumentation: New Developments in Ionization and Sampling (Ionization) Ionization Mechanisms LC-MS: Sample Preparation (Part ) Lipids: Quantitative Analysis MALDI: Sample Preparation Metabolomics: Identification of Unknown Metabolites Metabolomics: Quantitative Analysis Natural and Nanomaterials Peptides: Fragmentation Mechanisms Peptides: Quantitative Analysis Peptides: Sequence Analysis Peptidomics Protein Therapeutics: Structural Characterization Proteins: Conformation Analysis and Structural Biology Proteins: PTMs (Part ) Proteomics: New Approaches (Other) Proteomics: Quantitative (Pre-MS and Platforms/ Informatics/MultiOmics/Dynamics) Proteomics: Tissue Small Molecules: Quantitative Analysis (Part ) Systems Biology (Protein Modifications and Cells) Toxicology PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

59 MONDAY POSTERS Set up all Monday posters...7:0 8:00 am Odd-numbered posters present...0:0 am :00 pm Even-numbered posters present...:00 :0 pm Remove all Monday posters...7:0 8:00 pm Antibodies & Antibody Drug Conjugates (Intact and Characterization) Biomolecular Structure Analysis: Covalent Labeling and Related Software Carbohydrates Data Independent Acquisition Diagnostic Clinical Chemistry (Applications) Drug and Metabolite Analysis: Novel Approaches for Dried Biological Samples Energy: Hydrocarbon and Petrochemical (Ultra Hi Res) Environmental Analysis: General (Part ) Environmental Analysis: Pharmaceuticals and Pesticides Epigenetic Modifications High Mass Accuracy/High Performance MS Applications Imaging MS: Instrumentation... - Imaging MS: Sample Preparation Imaging MS: Software Informatics: Metabolomics Informatics: Multiomics Integration Instrumentation: New Concepts Intact Proteins Ion Activation/Dissociation Ion Mobility: Applications (Other/Instrumentation) Ion Molecule, Ion/Ion, Ion/Electron Interactions Ion Spectroscopy LC-MS: Chromatography and Software (Part ) Lipids: General Metabolomics: General Microorganisms: Identification and Characterization Phosphopeptides: Enrichment Methods Polymers Proteins: General and Membrane Proteins: PTMs (Part ) Proteomics: Clinical Applications (Applied Proteomics) Proteomics: Quantitative Small Molecules: Qualitative Analysis Systems Biology (Multiomics and Other) Top Down Protein Analysis (Applications) Antibodies & Antibody Drug Conjugates (Intact & Characterization) MP 00 Integrating Intact, Reduced and IdeS Approaches for Rapid Differentiation and Verification of Monoclonal Antibodies Using Liquid Chromatography Q-Exactive Mass Spectrometry; Lianji Jin; FDA, Cincinnati, OH MP 00 Online Separation and Characterization of intact IgG Fabs Using Ultra Performance Liquid Chromatography Coupled with Top-down Mass Spectrometry; Zhe Wang ; Kenneth Smith ; Si Wu ; University of Oklahoma, Dept. of Chem & Biochem Norman, OK; Oklahoma Medical Research Foundation, Oklahoma City, OK MP 00 Evaluation of Different Immunocapture Platforms for Antibody-Conjugate Drug Quantification; Ling Xu ; Shaoxia Yu ; Jing-Tao Wu ; Mark Qian ; Millennium Pharma, Cambridge, MA; Takeda Pharmaceutical International Inc., Cambridge, MA; Takeda Pharmaceuticals International Inc., Cambridge, MA MP 004 Intact Mass Analysis of Antibody-drug conjugates (ADCs) as a Tool to Measure Payloads of Linked Cytotoxic Drugs; Joe Shambaugh ; Cassandra Wigmore ; Maurizio Bronzetti ; David Bush ; Arnd Brandenburg ; Peter Haberl ; Genedata Inc, Lexington, MA; Genedata AG, Basel, Switzerland; Genedata GmbH, Munich, Germany MP 005 MP 006 MP 007 MP 008 MP 009 MP 00 MP 0 MP 0 MP 0 MP 04 MP 05 MP 06 Characterization of Bispecific Antibodies Using Mass Spectrometry during Cell Line Development is Critical for an Optimized Final Drug Product; Michael Bacica ; Jon R Fitchett ; Stephen J Demarest ; Xiufeng Wu ; Robert Peery ; Bryan Jones ; Lilly Biotech Center-San Diego, San Diego, CA; Lilly BioTDR, Indianapolis, IN Developability Assessment of Multispecific Biopharmaceuticals; Kadir Ilker Sen ; Eric Beil ; Hirsh Nanda ; Andrew Mahan ; Darryl Davis ; Janssen Research and Development, Spring House, PA Monitoring the Critical Quality Attributes of Antibody Drug conjugates (ADCs) as Part of Biosimilar Development: Case Studies of ado-trastuzumab emtansine; Liuxi Chen ; Min Du ; Henry Y Shion ; Ying- Qing Yu ; Lan Wang ; Kai Gao ; Weibin Chen ; Waters Corporation, Milford, USA; National Institutes for food and drug control, Beijing, CN Detection of an Amino Acid Sequence Variant as a Function of Cell Line Stability in a Model Antibody; Sylwia Jozwiak ; James Graham ; Lonza, Slough, UK Assessment of Critical Parameters for the Mass Spectrometric Evaluation of the Drug-to-Antibody Ratio in Antibody-Drug Conjugates; Neil Hershey ; Shiyue Zhou ; Yunping Huang ; Hangtian Song ; Hui Wei ; Jacob Bongers ; Richard Ludwig ; Li Tao ; Tapan Das ; Bristol- Myers Squibb, Hopewell, NJ; Texas Tech University, Lubbock, Texas An Automated Quantitative Mass Spectrometry Assay to Determine Intra-Cellular Retention Kinetics of Antibiotic Released from Anti-Staphylococcus Aureus Antibody- Antibiotic Conjugate; Hilda Hernandez-Barry ; Kimberly Kajihara ; Daniel Tran ; Martine Darwish ; Byoung-Chul Lee ; Richard Vandlen ; Leanna Staben ; Thomas Pillow ; Wouter Hazenbos ; Kelly Loyet ; Genentech, South San Francisco, CA; Genentech Inc, South San Francisco, CA An Automated Sample Extraction and Processing Method Combining Ligand Binding and Mass Spectrometry Analysis for Biotherapeutics Quantitation; Ian Moore; SCIEX, Concord, ON A Comprehensive Mass Spectrometric Workflow for Characterizing Therapeutic Antibodies; Alicia Bielik ; Paula Magnelli ; Beth McLeod ; Colleen McClung ; Beth Paschal ; Cristian I Ruse ; Xiaofeng Shi ; Ellen Guthrie ; New Englanb Biolabs, Ipswich, MA Drug-to-Antibody Ratio Determination for Antibody- Drug Conjugates in Serum Enabled by a Sample Preparation Platform that Automates Affinity Purification and Deglycosylation; Jing Chen ; Maryann Shen ; Steve Murphy ; Agilent Technologies, Inc. Madison, WI; Agilent Technologies, Santa Clara, CA Platform Method for Identity and Characterization of Therapeutic Monoclonal and Bispecific Antibodies by Intact and Reduced Mass Spectrometry; Richard Seipert ; Lisa Patterson ; George Tsui ; Chris Yu ; Genentech, South San Francisco, CA; Genentech Inc, South San Francisco, CA A Tag-free Collisionally-Induced Fragmentation Technique Applied to Studies of Antibody-drug Conjugate Lysosomal Processing; Andrew Bessire ; Chakrapani Subramanyam ; My-Hahn Lam ; Frank Loganzo ; T. Eric Ballard ; Pfizer, Inc., Groton, CT; Pfizer, Groton, CT; Pfizer Oncology-Rinat R&D, Pearl River, NY Strategy to Rapidly and Comprehensively Characterize Innovator Biologics and their Biosimilars via Stress Testing Studies; Esthelle Hoedt ; St John Skilton ; Yong J Kil ; Eric Carlson 4 ; Chris Becker ; Beatrix M Ueberheide ; NYU School of Medicine, New York City, NY; Protein Metrics, Hopkinton, MA; Protein Metrics, San Carlos, CA; 4 Protein Metrics Inc., San Carlos, CA 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 59

60 GENERAL MONDAY INFORMATION POSTERS MP 07 MP 08 MP 09 MP 00 Method Development for the Detection and Quantitation of Monomethyl Auristatin F (MMAF) in Cell Culture Media; Maria Christina Malinao ; Melissa M. Williams ; Cody Warhurst ; Julien Dugal-Tessier ; Josh T. Snyder ; Brian Mendelsohn ; Hui Zhao ; Sara Gulesserian ; Hosein Kouros-Mehr ; Kendall Morrison ; Agensys, Inc. Santa Monica, CA In-Depth Characterization of Monoclonal Antibodies with a Single Experiment and Fully Automated Data Analysis; Paul Taylor ; Johnathan Krieger ; Qixin Liu ; Mingjie Xie ; Lian Yang, ; Bin Ma ; Hospital for Sick Children, Toronto, Canada; Rapid Novor Inc., Waterloo ON, Canada; University of Waterloo, Waterloo ON, Canada Antibody Variable Domains as Intramolecular Luciferase Inhibitors for the Generation of Proteolysis- Activated Biosensors; Lining Zhu ; Teresa Hong ; Nicola McNiven ; Markus Kalkum ; City of Hope, Duarte, CA Novel Strategy Based on Dual Enrichment and Double Lists for Characterization of Host Cell Proteins; Zheng- Xiang Zhang ; Jimmy Chan ; Shuai Zuo ; Tao Bo ; Rong An ; Agilent Technologies (China) Limited, Beijing, China Biomolecular Structure Analysis: Covalent Labeling and Related Software 0-09 MP 0 Using High Resolution Structural Analysis to Determine if FPOP Modification Perturbs Native Protein Structure; Emily Hart ; Lisa M Jones ; IUPUI Department of Chemistry & Chemical Biology, Indianapolis, IN MP 0 Extension of the FPOP Method for Oxidative Modification in Live Tissue; Jessica Arlett Espino ; Anthony J Baucum ; Lisa M Jones ; Indiana University- Purdue University Indianapolis, Indianapolis, IN; Indiana University Purdue University Indianapolis, Indianapolis, In MP 0 Epitope Map of Malarial Antigen PvDBP revealed by Fast Photochemical Oxidation of Proteins (FPOP); Manolo David Plasencia ; Yining Huang ; Henry W Rohrs ; Edwin Chen ; Nichole D. Salinas ; Niraj H. Tolia ; Michael L Gross ; Washington University in St. Louis, St. Louis, MO; Washington University School of Medicine, St. Louis, MO MP 04 The Application of Droplet-Like Methods to FPOP; Don L. Rempel ; Supratik Dutta ; Ben Niu ; Yining Huang ; Manolo Plasencia ; Michael Gross ; Center for Biomedical and Bioorganic Mass Spectrometry, Washington University in St. Louis, St Louis, MO; Center for Biomedical and Bioorganic Mass Spectrometry, Washington University in St. Louis, St. Louis, MO MP 05 Normalization of High Resolution Hydroxyl Radical Protein Footprinting Data to Protein Structural Properties; Boer Xie ; Amika Sood ; Robert J Woods ; Joshua S. Sharp ; University of Georgia, Athens, GA; University of Mississippi, University, MS MP 06 Automated Hydroxyl Radical Protein Footprinting for the Determination of Biopharmaceutical Protein Conformation; Franklin E. Leach III ; Ron Orlando ; Joshua S Sharp ; Photochem Technologies, Athens, GA; Complex Carbohydrate Research Center UGA, Athens, GA; School of Pharmacy, University of Mississippi, Oxford, MS MP 07 Develop Isotope-encoded Photoaffinity Footprinting Reagent for Structural Mass Spectrometry Studies; Ming Cheng ; Michael L Gross ; Washington University in St. Louis, St. Louis, MO MP 08 Exploring the Peroxidase Activation and Deactivation of Cytochrome C by Heme-Catalyzed Oxidative Labeling and ESI-MS; Victor Yin ; Lars Konermann ; Western University, London, Canada MP 09 MP 00 MP 0 MP 0 MP 0 MP 04 MP 05 MP 06 Comprehensive Measurement of Protein Dynamics in Complex Environments Using Footprinting Mass Spectrometry with Inexpensive MS Quantification of Labeled Cysteines; Jenna Gray Caldwell ; Pehr A. B. Harbury ; Stanford University School of Medicine, Palo Alto CA Using Covalent Labeling and Mass Spectrometry to Study b--microglobulin-inhibitor Binding Sites; Tianying Liu ; Richard W Vachet ; University of Massachusetts Amherst, Amherst, MA Towards an Improved Understanding of Diazirine Labeling for Structural Mass Spectrometry Applications; Daniel Ziemianowicz ; Chris Etienne ; David Schriemer ; University of Calgary, Calgary, Canada; Thermo Fisher Scientific, Rockford, IL Characterisation Proteolytic Process by Protein N-Terminal Derivatisation in- Gel Using MS-Based Approach in Drosophila; Nina Guillaumot ; Florian Veillard ; Jean-Marc Reichhart ; Alain Van dorsselaer ; Christine Schaeffer-Reiss ; Laboratoire de Spectrométrie de Masse BioOrganique, IPHC, Université de Strasbourg, CNRS, UMR778, Strasbourg, Strasbourg, France; Institut de Biologie Moléculaire et Cellulaire, IBMC, Université de Strasbourg, CNRS UPR 90, Strasbourg, Strasbourg, France Covalent Labeling Denaturation Mass Spectrometry for Sensitive Localized Higher Order Structure Comparisons; James A. Madsen ; Yan Yin ; Jing Qiao ; Vanessa Gill ; Kutralanathan Renganathan ; Wing-Yee Fu ; Stephen Smith ; James Anderson ; Momenta Pharmaceuticals, Cambridge, MA Xilmass: A New Approach Towards the Identification of Cross-Linked Peptides; Şule Yılmaz,, ; Friedel Drepper 4, 5 ; Maša Černič 6 ; Kris Gevaert, 7 ; Anastassios Economou 8, 9 ; Bettina Warscheid 4, 5 ; Lennart Martens, 7, 0 ; Elien Vandermarliere, 7, 0 ; Department of Biochemistry, Ghent University, Ghent, BELGIUM; Medical Biotechnology Center, Ghent, BELGIUM; Bioinformatics Institute Ghent, Ghent, BELGIUM; 4 Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, Freiburg, Germany; 5 BIOSS Centre for Biological Signaling Studies, University of Freiburg, Freiburg, Germany; 6 Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins, Ljubljana, Slovenia; 7 Medical Biotechnology Center, VIB, Ghent, BELGIUM; 8 Laboratory of Molecular Bacteriology, Rega Institute for Medical Research, Department of Microbiology and Immunology, KULeuven, Leuven, BELGIUM; 9 Institute of Molecular Biology and Biotechnology-FoRTH, Department of Biology University of Crete, Iraklio, Crete, Greece; 0 Bioinformatics Institute Ghent, Ghent University, Ghent, BELGIUM Crosslinkers with Isotope-Coding and Cleavable Spacers Improve Peptide Crosslink Identification by a Semi-Supervised Machine Learning Algorithm; Karl A T Makepeace ; Evgeniy V Petrotchenko ; Christoph H. Borchers, ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; University of Victoria - Genome BC Proteomics Centre, Victoria, BC; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada A Simple Approach for Creating Protein Structural Models Based on Cross-Linking Data; Zsuzsanna Orban-Nemeth ; Evelyn Rampler ; Thomas Stranzl ; David Maria Hollenstein ; Otto Hudecz ; Peter Schloegelhofer 4 ; Karl Mechtler, ; Institute of Molecular Pathology, Vienna, Austria; Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria; Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria; 4 Department PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

61 MONDAY POSTERS MP 07 MP 08 MP 09 MP 040 MP 04 MP 04 MP 04 MP 044 MP 045 MP 046 MP 047 MP 048 of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria CX-Circos: A Web-Based Tool for Visualization and Analysis of Chemical Crosslinking Data; Junjie Wang ; Yi Shi ; Brian T. Chait ; Rockefeller University, New York, NY In Cell Protein Footprinting Coupled with Mass Spectrometry to Probe Protein Conformational Change; Maissa M Gaye ; Lisa Jones ; Indiana University-Purdue University Indianapolis, Indianapolis, IN High-throughput Mass Spectrometric Analysis of Covalent Protein-inhibitor Adducts, Monoclonal Antibodies and ADCs: A Complete Workflow; Tisha San Miguel ; Jelly Netirojjanakul ; Rowe Todd ; Onea Daniel ; Victor Cee ; Arvedson Tara ; McCarter John ; Campuzano Iain ; Amgen, Inc., Thousand Oaks, CA Carbohydrates Quantifying Cyclodextrin-Drug Interactions by ESI-MS; Emma-Dune Leriche ; Ping Zhang ; Aixia Wang ; Yuyu Yao ; Chang-Chun Ling ; Elena N Kitova ; John S Klassen ; University of Alberta, Edmonton, Canada; University of Calgary, Calgary, Canada Identification and Relative Quantification C-mannosylation of Interleukin 6 (IL-6) using Liquid Chromatography-tandem Mass Spectrometry; Anhdao Darcy; Abbvie Bioresearch Center, Worcester, MA Development of Negative Mode Free Radical Activated Glycan Structure Elucidation Reagents; Jinshan Gao ; Nikunj Desai ; Jungeun Lee ; Montclair State University, Montcalir, NJ Carbohydrate Analysis using Gas Chromatography Vacuum Ultraviolet Spectroscopy in Comparison with Gas Chromatography Mass Spectrometry; Jamie Schenk ; Xiaojian Mao ; Jonathan Smuts ; Gabe Nagy ; Nicola L. B. Pohl ; Phillip Walsh ; Peter Kroll ; Kevin A Schug ; University of Texas at Arlington, Arlington, TX; VUV Analytics, Inc., Cedar Park, TX; Indiana University, Bloomington, IN Understanding the Reaction Products of Methanolysis and Butanolysis of Heparan Sulfate; Marten F Snel ; Paul J Trim ; John J Hopwood ; Qi Qi He ; Vito Ferro ; South Australian Health and Medical Research Institute, Adelaide, South Australia; LDRU, Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, Australia; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia LC-MS Analysis of the Complete Molecular Weight Distribution of Low Molecular Weight Heparins; Yuewei Sheng ; Chun Shao ; Kshitij Khatri ; Joseph Zaia ; Boston University School of Medicine, Boston, MA; Boston University, Boston, MA Size-Selective Controlled Heparin Depolymerization to Obtain Heparin Oligosaccharides; Sandeep K Misra ; Joshua S Sharp ; Dept of Biomolecular Sciences, University of Mississippi, Oxford, MS Oxidation of Glucose at Gold Nanoparticles and Mass Spectrometric Product Analysis; Marilyn Wooten ; Wendell P. Griffith ; Sushma Karra ; Waldemar Gorski ; Trinity University, San Antonio, TX; University of Texas at San Antonio, San Antonio, TX Study of Rearrangement Products in Collision-Induced Dissociation and Surface-Induced Dissociation of Oligosaccharides and Glycoconjugates; Forouzan Aboufazeli ; Eric D Dodds ; University of Nebraska-Lincoln, Lincoln, NE MP 049 MP 050 MP 05 MP 05 MP 05 MP 054 MP 055 MP 056 MP 057 MP 058 MP 059 Single Stage Tandem Mass Spectrometry Assignment of the C-5 Uronic Acid Stereochemistry in Heparan Sulfate Tetrasaccharides Using Electron Detachment Dissociation; Isaac Agyekum ; Chengli Zong, ; Geert-Jan Boons, ; Jon Amster ; University of Georgia,Chemistry Department, Athens, GA; University of Georgia, Chemistry Department Athens, GA; CCRC, University of Georgia Athens, GA Mass Spectrometric Quantification of Cell Wall Composition Differences in Enterococcus Using Stable Isotope Labeling by Amino Acids; James Chang ; Ashley Wallace ; Erin Foster ; Alex Guinn ; Sung Joon Kim ; Baylor University, Waco, TX High Resolution CESI-MS Analysis of APTS-Labeled N-Glycans of Biopharmaceutical Interest; Fonslow Bryan; Marton Szigeti ; Andras Guttman ; University of Debrecen, Debrecen, Hungary; AB Sciex, San Diego, CA Probing Carbohydrate Isomerism through Transition Metal Ion Adduction, Gas-Phase Ion Chemistry, and Collision-Induced Dissociation; Katherine Schumacher ; Yuting Huang ; Lauren Petrosh ; Eric D Dodds ; University of Nebraska - Lincoln, Lincoln, NE ESI-TOF-MS Study of Carbohydrate Interaction with Metal Complexes with Carboxylate-Rich Ligand; Fangzhi Yan ; Christopher D. Stewart ; Stephan B. H. Bach ; Wendell P Griffith ; Ghezai T. Musie ; University of Texas at San Antonio, San Antonio, TX Fragmentation of Derivatized and Non-Derivatized Metal-Adducted Oligosaccharides; Ranelle Schaller- Duke; The University of Alabama, Tuscaloosa, Al A Novel Method for High-Throughput Analysis of Bioactive Oligosaccharides; Randall Robinson ; Daniela Barile ; University of California, Davis, Davis, CA Data Independent Acquisition Advances in Targeted Omics Quantitation Using a Novel Scanning Quadrupole DIA Method; Chris Hughes ; Keith Richardson ; Jason Wildgoose ; Martin R Green ; Richard Chapman ; Arkadiusz Grzyb ; Praveen Harapanahalli ; Kirsten Craven ; Waters, Wilmslow, United Kingdom Optimisation of Data Independent Acquisition (DIA) Data Extraction for Proteome Quantification; Gauthier Husson ; Alvaro Sebastian Vaca Jacome ; Maxime Eveque ; Christine Carapito ; Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), IPHC, Strasbourg University, CNRS, UMR778, Strasbourg, France Improved Multiplexed Data Independent Acquisition: Sensitivity, Dynamic Range, and Full-Spectrum Demultiplexing; Jarrett Egertson ; Ying Sonia Ting ; Philip M Remes ; Romain Huguet ; Derek Bailey ; Michael Senko ; Vlad Zabrouskov ; Michael J MacCoss ; Univ of Washington, Seattle, WA; Thermo Fisher Scientific, San Jose, CA Analytical Validation of a Data-Independent Acquisition Mass Spectrometry Workflow for Quantification and Identification of Myofilament Proteoforms in Cardiac Biopsies; Irene van den Broek ; Irina Tchernyshyov ; Vidya Venkatraman ; Giulio Agnetti, ; Amol Prakash 4 ; Scott Peterman 5 ; Jennifer E Van Eyk ; Advanced Clinical Biosystems Research Institute, Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA; Division of Cardiology. Johns Hopkins University School of Medicine, Baltimore, MD; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; 4 Optys Tech Corporation, Brighton, MA; 5 Thermo Fisher Scientific, Cambridge, MA 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 6

62 GENERAL MONDAY INFORMATION POSTERS MP 060 MP 06 MP 06 MP 06 MP 064 MP 065 MP 066 MP 067 MP 068 MP 069 MP 070 Computational Workflows to Improve DIA Data Analysis Without Reference Libraries for Quantitative Proteomics and PTM Analysis; Jesse Gerard Meyer ; Birgit Schilling ; Samir Softic ; C. Ronald Kahn ; Bradford W Gibson ; Buck Institute for Research on Aging, Novato, CA; Joslin Diabetes Center and Harvard Medical School, Boston, MA Evaluation of the Efficacy of Data-Independent Acquisition Using Hyper Reaction Monitoring in Quantitative Proteome Profiling of Diverse Species; Jing Wang ; Jeong-Jin Park ; David R Gang ; Washington State University, Pullman, WA Data Independent Infrared Multiphoton Dissociation for Selective Identification of Cysteine Oxidized Peptides; Nicholas Borotto ; Phillip McClory ; Jaimeen Majmudar ; Brent Martin ; Kristina Hakansson ; University of Michigan, Ann Arbor, MI Effect of Peptide Assay Library Size and Composition in Targeted Data Independent Acquisition-Mass Spectrometry Analyses; Vidya Venkatraman ; Sarah Parker ; Jennifer E Van Eyk ; Advanced Clinical Biosystems Research Institute, Los Angeles, CA Spectral Library with High Confident PTM Site Localization for Phosphoproteome DIA Analysis; Wei Zhang ; Yue Zhou ; Jing Li ; Thermo Fisher Scientific (China), Shanghai, China Triple Quad Two-Dimensional Scanning: A Novel Scan Approach to Highlight Relationships and Couplings between Unknowns in Complex Mixtures; Cassandra L. Smith ; Vincent S. Pagnotti ; PPG Industries, Allsion Park, PA; PPG Industries, Allison Park, PA A Case for Generating Organized and Comprehensive Digital Chromatogram Archives of Every Peptide Quantified in Large-Scale DIA Proteomics; Michael R Heaven ; Archie L Cobbs ; Harsha P Gunawardena ; Adam J Funk ; Michael J Ford 4 ; Scott A Shaffer 5 ; Jeremy L Norris 6 ; Vulcan Analytical, Birmingham, USA; University of North Carolina, Chapel Hill, NC; University of Cincinnati, Cincinnati, Ohio; 4 MS Bioworks, LLC Ann Arbor, MI; 5 University of Massachusetts Medical School, Worcester, MA; 6 Vanderbilt University, Nashville, TN Unraveling the Proteome of Differentiating Human Embryonic Stem Cells Using HDMSEDIA MS; Elisabeth Govaert ; Katleen Van Steendam ; Maarten Dhaenens ; Liesbeth Vossaert ; Dieter Deforce ; Ghent University, Laboratory of Pharmaceutical Biotechnology, Ghent, Belgium Analysis of Phorphorylation Site and Occupancy Using Data Independent Acquisition with Electron Transfer Dissociation Mass Spectrometry; Chein-Hung Chen ; Ya-Ping Lin ; Chia-Lin Wu ; Jung-Lee Lin ; Chung-Hsuan Chen ; Academia Sinica, Taipei, Taiwan; Genomics Research Center, Academia Sinica Taipei, Taiwan Using -Dimensional Mass Spectrometry (DMS) for Proteomics; Peter B. O Connor ; Maria van Agthoven ; Pui Yiu Lam ; Federico Floris ; Alice Lynch ; Marc-André Delsuc 4 ; University of Warwick, Coventry, West Midlands; University of Warwick, Coventry, UK; University of Warwick, Covenrtry, UK; 4 University of Strasbourg, Strasbourg, France Improvements in LFQ for Reproducible Quantification of Proteomic Experiments: How DDA Outperforms DIA; Andreas Huhmer ; Ignacio Ortea ; Michael Blank ; Daniel Lopez-Ferrer ; Romain Huguet ; David Horn ; Thermo Fisher Scientific, San Jose, CA; IMIBIC, Cordoba, Spain Diagnostic Clinical Chemistry (Applications) MP 07 Mass Spectrometric Identification and Clarification of the in Vesica Formation of the Diuretic Chlorazanil in Sports Drug Testing Samples; Mario Thevis ; Hans Geyer ; Andreas Thomas ; Laura Tretzel ; Isabelle Bailloux ; Corrine Buisson ; Markus Kellmann 4 ; Catharina Crone 4 ; Thomas Moehring 4 ; Wilhelm Schänzer ; German Sport University, Cologne, NRW; German Sport University, Cologne, DE; Agence Francaise de Lutte contre le Dopage, Chatenay-Malabry, France; 4 Thermo Fisher Scientific, Bremen, DE MP 07 Development of a Sensitive and Specific LC-MS/ MS Method for Rapid Diagnosis of Niemann-Pick C Disease; Rohini Sidhu ; Xuntian Jiang ; Sarah Gale ; David Scherrer ; Jean Schaffer ; Daniel Ory ; Washington University in Saint Louis, Saint Louis, MO; Washington University in St. Louis, saint louis, MO; Washington University in St. Louis, St. Louis, MO MP 07 A UHPLC-MS/MS Method for the Simultaneous Quantification of 0 Antihypertensive Drugs in Human Plasma; Amedeo De Nicolò ; Marco Simiele ; Gabriele Bonifacio ; Valeria Avataneo ; Paolo Mulatero ; Franco Rabbia ; Franco Veglio ; Giovanni Di Perri ; Antonio D Avolio ; Laboratory of Clinical Pharmacology and Pharmacogenetic, Unit of Infectious Diseases, University of Turin, Department of Medical Sciences, Amedeo di Savoia Hospital, Turin, Italy; Unit of Internal Medicine, University of Turin, Department of Medical Sciences, Città della Salute e della Scienza, Turin, Italy MP 074 Multiplexed Enzymatic Assay for New-Born Screening of Mucopolysaccharidoses(type II, IIIB, IVA, VI, VII) and Neuronal Ceroid Lipofuscinosis II; Yang Liu ; Zdenek Spacil ; Hsuan-Chieh Liao ; Martin Sadilek ; Michael Gelb ; Ronald Scott ; Frantisek Turecek ; University of Washington, Seattle, WA; Masaryk University,Research Centre for Toxic Compounds in the Environment, Brno, Czech Republic; University of Washington, Department of Pediatrics, Seattle, WA MP 075 Early release of -pyrroline by Pseudomonas aeruginosa Cultures Discovered Using Ambient Corona Discharge Ionization Mass Spectrometry; Juchao Liang ; Konstantin Chingin ; Longhua Hu ; Yaping Hang ; Huanwen Chen ; East China Institute of Technology, Nanchang, China; The Second Affiliated Hospital of Nanchang University, Nanchang, China; East China University of Technology, Nanchang, Mainland MP 076 Skin Transplant Quality Assessment by Multiplexed D MRM Mass Spectrometry A Step Forward to Improve Clinical Success Rates; Jingzhi Yang ; Juncong Yang ; Andrew Percy ; Uwe vonfritschen ; Juliane C. Finke ; Christoph H. Borchers, 4 ; Michael O. Glocker 5 ; Proteome Center Rostock, Rostock, Germany; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; HELIOS Clinic Emil von Behring, Berlin, Germany; 4 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; 5 Proteome Center Rostock, Rostock, Germany MP 077 Quantitative Clinical Chemistry Proteomics Applied to Apolipoproteins A-I / B / C-I / C-II / C-III / E in Serum; Yuri EM van der Burgt ; Renee Ruhaak ; Nico PM Smit ; Fred PHTM Romijn ; Arnoud van der Laarse ; Christa M Cobbaert ; Leiden University Medical Center (LUMC), Leiden, The Netherlands MP 078 Characterizing Traumatic Brain Injury with New Astroglial Injury Biomarkers Measured by Targeted Mass Spectrometry; Shen Sean ; Julia Halford ; Ina-Beate Wanner ; Joseph A. Loo ; UCLA, Los Angeles, CA PAGE 6 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

63 MONDAY POSTERS MP 079 MP 080 MP 08 MP 08 MP 08 MP 084 MP 085 MP 086 MP 087 MP 088 MP 089 High-Sensitivity, High-Throughput Quantitation of Catecholamine Metabolites in Urine by LC/MS/MS for Clinical Research; Atsuhiko Toyama ; Kumie Satou ; Yuki Nakamura ; Ichiro Hirano ; Shimadzu Corporation, Kyoto, Japan; LSI Medience Corporation, Tokyo, Japan High-Sensitivity, High-Throughput Quantitation of Catecholamines and Metanephrine in Plasma by Automated WCX-SPE Coupled to LC/MS/MS for Clinical Research; Ichiro Hirano ; Atsuhiko Toyama ; Kumie Satou ; Yuki Nakamura ; Jun Watanabe ; Shimadzu Corporation, Kyoto, Japan; LSI Medience Corporation, Tokyo, Japan LC/MS/MS Determination of Plasma Catecholamine Metabolites Without Requiring Solid-Phase Extraction or Sample Dry-Up for Clinical Research; Yusuke Inohana ; Atsuhiko Toyama ; Ichiro Hirano ; Shimadzu Corporation, Kyoto, Japan Discovery and Targeted Proteomics on Cutaneous Biopsies Infected by Borrelia for the Diagnosis of Lyme Disease.; Benoit Westermann ; Antoine Grillon ; Gilles Schnell ; Benoit Jaulhac ; Nathalie Boulanger ; Laurence Ehret-Sabatier ; Laboratoire de Spectrométrie de Masse BioOrganique, Institut Pluridisciplinaire Hubert Curien (UMR 778), CNRS-Université de Strasbourg, Strasbourg, France; EA790, Virulence bactérienne précoce, groupe Borréliose de Lyme, facultés de médecine et de pharmacie, Université de Strasbourg, Strasbourg, France Increased Levels of Serum Protein Complexes are Associated with Type Diabetes; Yujie Liu ; Bingchaoi Chen ; Yanmin Wang ; Mo Zhang ; Zhili Li ; Institute of Basic Medical Sciences, CAMS &PUMC, Bejing, CN; Heze Municipal Hospital, Heze, CN; IBMS, CAMS&PUMC, Beijing A Quantitative Assay for Serum Albumin and Creatinine in Urine Based on MALDI-TOF MS; Stephen J. Hattan ; Marvin Vestal ; Kenneth C Parker ; Mark Duncan, 4 ; Jane Yang 5 ; David Herold 6 ; Virgin Instruments/ SIMULTOF, Marlborough, MA; Virgin Instruments/ SIMULTOF, Marlborough, MA; University of Colorado, Boulder, Colorado; 4 University of Colorado School of Medicine, Aurora, CO; 5 University of California San Diego, La Jolla, CA; 6 University of California, San Diego La Jolla, CA Microorganism Identification/Classification by High Resolution Tandem Mass Spectrometry with Accurate Statistical Significance; Gelio Alves ; Guanghui Wang ; Aleksey Ogurtsov ; Steven Drake ; Marjan Gucek ; Anthony Suffredini ; David Sacks 4 ; YI-KUO YU ; National Center for Biotechnology Information, NLM, NIH, Bethesda, MD; Proteomics Core, NHLBI, NIH, Bethesda, MD; Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD; 4 Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD Urinalysis of Opiates Using a Small Benchtop Instrument Combining Microfluidic Capillary Electrophoresis-ESI with High Pressure Mass Spectrometry; Michael P Goodwin ; Scott Mellors ; Christopher D Brown ; 908 Devices Inc., Boston, MA Rapid, Simultaneous Analysis of Urinary Monoamine Neurotransmitters and their Metabolites by UPLC-MS/ MS; Zhengzhi Xie ; Sanjay Srivastava ; Pawel Lorkiewicz ; University of Louisville, Louisville, KY Screening and Quantitation of Pain and Antidepressant Drugs in Human Urine by Liquid Chromatography-High Resolution Mass Spectrometry; Ana Celia Grenier ; Lawrence Joseph Andrade ; Dominion Diagnostics, North Kingstown, RI LC-MS Method for Quantitation of HbAc in the Presence of the Most Common Hemoglobin Variants (S, C, D, and E); Shawn Connolly ; Kuanysh Kabytaev ; Curt Rohlfing ; Randie Little ; Department of Pathology & Anatomical Sciences University of Missouri Columbia, Columbia, MO MP 090 MP 09 MP 09 MP 09 MP 094 Development of a High-Throughput Hemoglobinopathies Workflow Using High Resolution Accurate Mass Analysis; Scott Peterman; Thermo Fisher Scientific, Grimes, IA Functionalized Surfaces for Direct Immuno-Affinity Mass Spectrometry - Detection of Haptoglobin Phenotypes; Petr Pompach,, ; Jana Novakova ; Daniel Kavan, ; Oldrich Benada ; Viktor Ruzicka 4 ; Michael Volny ; Petr Novak,, ; Institute of Microbiology, Prague, Czech Republic; Faculty of Science, Charles University in Prague, Prague, Czech Republic; AffiPro, Mratin, Czech Republic; 4 BioVendor, Brno, Czech Republic Identifying Vitamin D and D, Their 5-OH Metabolites, and C Epimers in a Single LCMS Run; Ken Tseng ; Toshi Ono ; Tsunehisa Hirose ; Nacalai USA Inc., San Diego, CA; Nacalai USA Inc., San Diego, CA - California; Nacalai Tesque Inc., Kyoto, Japan A Simple and Effective LC/MS/MS Method Development for the Determination of Underivatized Vitamin B and B6 in Human Whole Blood; Xianrong (Jenny) Wei ; Sean Orlowicz ; Phenomenex, Torrance, ca; Phenomenex, Torrance, CA Speciation of Fatty Acids in Human Serum by Gas Chromatography/Mass Spectrometry; Bruce A. Benner ; Benjamin J Place ; Jacolin A Murray ; NIST, Gaithersburg, MD Drug and Metabolite Analysis: Novel Approaches for Dried Biological Samples MP 095 Insights on Microsampling Implementation in Drug Discovery: Sample Collection, Matrix Effect, Recovery, Aging and Automation s Assessment for an Emerging Technology; Graziella Bovi ; Silvana Olivieri ; Giuseppe Santo ; Mariangela Corradin ; James Rudge ; Fabio Garofolo ; Serena Tongiani ; Angelini Research Center, Pomezia (Rome), Italy; Neoteryx, Torrance, CA MP 096 A New Microsampling Hematocrit-Compatible Dried Plasma Card for Fully Automated Online DBSA-SPE-LC- MS/MS Bioanalysis of Opioids in Blood; Imelda Ryona ; Jack Henion ; Q Solutions, Ithaca, NY MP 097 Bioanalysis of Emixustat (ACU-449) in Whole Blood Collected with Volumetric Absorptive Microsampling by LC MS/MS; Zhixin Miao ; James G Farnham ; Glenn Hanson ; Terry Podoll ; Michael J. Reid ; Covance, Madison, WI; Acucela, Bothell, WA MP 098 Improving Transplant Patient s Welfare; Standardising and Advancing the Therapeutic Drug Monitoring of the Immunosuppressant Drug Tacrolimus; Dima AlMekdad, ; Mark Christian Parkin ; Chris Mussell ; King s College London, London, UK; LGC, Teddington, UK; King s College London, London, United Kingdom MP 099 Development and Validation of an UHPLC-MS/MS Method to Quantify Imatinib, Desmethylimatinib, Dasatinib, Nilotinib and Ponatinib in Dried Plasma Spots; Alessandra Ariaudo ; Simiele Marco ; Fabio Favata ; Luca Paglietti ; Silvia De Francia ; Giovanni Di Perri ; Antonio D Avolio ; Laboratory of Clinical Pharmacology and Pharmacogenetics. Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy, Torino, Italy; Laboratory of Clinical Pharmacology. Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano (Turin), Italy, Orbassano, Italy MP 00 Evaluation of Blood Fractionation Membranes for the Analysis of Dried Plasma Spots from Whole Blood Using Paper Spray Mass Spectrometry; Brandon Bills ; Nicholas E Manicke ; IUPUI Department of Chemistry & Chemical Biology, Indianapolis, IN 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 6

64 GENERAL MONDAY INFORMATION POSTERS MP 0 MP 0 MP 0 Method Development Considerations for Paper-Spray Mass Spectrometry - Direct Ionization Technique for Physiological Fluid Analysis; Maria C. Prieto CONAWAY ; Jeff Patrick ; Joseph Kennedy ; Kristine Van Natta ; Marta Kozak ; Thermo Fisher Scientific, San Jose, CA; Prosolia, Inc. Indianapolis, IN; Thermo Fisher Scientific, San Jose, CA Ambient Mass Spectrometric Analysis of Herbal Medicines with Flowing Atmospheric-Pressure Afterglow; Xinyue Liang ; Xiaoxia Gong ; Songyue Shi ; Mohammad Choudhury ; Gerardo Gamez ; Texas Tech University, Lubbock, TX Evaluation of Protein Stability in Dried Plasma Spots Using Targeted and Untargeted Mass Spectrometry Techniques; Victoria David ; Kristine Tsantilas ; Matthew Rosenow ; Marissa Saltzman ; Lizzi Neylon ; David Carpentieri ; Konstantinos Petritis ; Patrick Pirrotte ; Translational Genomics Research Institute, Phoenix, AZ; Phoenix Children s Hospital, Phoenix, AZ Energy: Hydrocarbon and Petrochemical (Ultra Hi Res) 04 - MP 04 Understanding the Oxygenation Mechanism of Hydrocarbons in the Ocean Utilizing SA-TIMS-FT-ICR MS; Paolo Benigni ; Rebecca Marin ; Kathia Sandoval ; Christopher J Thompson ; Mark E Ridgeway ; Melvin Park ; Piero Gardinali ; Francisco Fernandez-Lima ; Florida International University, Miami, FL; Bruker Daltonic, Billerica, MA MP 05 Unsupervised Chemical Structure Assignment Based on SA-TIMS-FTICR MS Mass and Mobility Measurements for Oxygenation Products of Hydrocarbons in the Ocean; Rebecca Marin ; Paolo Benigni ; Francisco Fernandez-Lima ; Christopher Thompson ; Mark E Ridgeway ; Melvin Park ; Florida International University, Miami, FL; Bruker Daltonic, Billerica, MA MP 06 Ionization of Paraffin Samples With/Without Solvents and Analysis Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry; Izaak Tyson-Hirst ; Mark P. Barrow ; University of Warwick, Coventry, United Kingdom MP 07 Structural Elucidation of N-Containing Compounds in Crude Oil Using Positive Ion ESI FT-ICR MS/MS; Ammar Nasif ; Christianne Wicking ; Mike Hodges ; John Couves ; Huang Zeng 4 ; John G Langley ; Chemistry, University of Southampton, Southampton, UK; BP Pangbourne Technology Centre, Pangbourne, UK; BP Sunbury ICBT, Sunbury, UK; 4 BP Houston, Houston, TX MP 08 Asphaltenes Generated from Low-temperature Cracking of Type II Kerogen: Molecular Characterization by Negative ESI-FT-ICR-MS and Kinetic Parameters; Albert Kamga ; Patrick G Hatcher ; Francoise Behar ; Francois Baudin 4 ; ODU Research Foundation, Norfolk, VA; Old Dominion University, Norfolk, VA; TOTAL Refining and Chemicals, Gonfreville l Orcher, France; 4 Universite Paris Descartes, Sorbonne Paris Cite Paris, France MP 09 Structural Determination of Nitrogen-Containing Compounds in Petroleum Using Collision Cross Section Calculations (CCS) and Collision-Induced Dissociation (CID); Hossein Maleki ; Sadegh Faramarzi Ganjabad ; Samaneh Ghassabi Kondalaji ; Stephen James Valentine ; West Virginia University, Morgantown, WV MP 0 Petroleomic Analysis of Tyre Pyrolysis Oils by Using High-Resolution ESI/APPI FT-ICR Mass Spectrometry; Janne Janis; University of Eastern Finland, Joensuu, NA MP MP MP MP 4 MP 5 MP 6 MP 7 MP 8 MP 9 MP 0 Two-Dimensional Matrix Plots for Mapping Genealogical Links in Complex Mixtures of Lignin Degradation Products; Yulin Qi ; Dietrich A Volmer ; Saarland University, Saarbrücken, Saarland; Saarland University, Saarbrücken, Germany Adaptation of SARA Fractionation with Emphasis on Resins and Asphaltenes Characterization in Crude Oils with Different API Gravity Using FT-ICRMS; Jandyson M Santos, ; Alberto Wisniewski Jr ; Marcos N Eberlin ; Wolfgang Schrader ; University of Campinas, Campinas, Brazil; Max-Planck Inst für Kohlenforschung., Mülheim / Ruhr, Germany; Federal University of Sergipe, São Cristóvão, SE Extrography and Column Chromatography Fractionation as Tools for Increasing Compositional Space Accessibility in HRMS Analysis of Crude Oils; Deisy Giraldo-Davila ; Martha L. Chacon ; Marianny Y Combariza ; Cristian Blanco-Tirado ; Andrea Gomez- Escudero ; Jorge A Orrego-Ruiz ; Universidad Industrial de Santander, Bucaramanga, Santander, Colombia; Universidad Industrial de Santander, Bucaramanga, Santander; Ecopetrol, Instituto Colombiano del Petróleo, Piedecuesta, Colombia HRMS Analysis of Naphthenic Acids Isolated from Heavy Crude Oils Using Ion Exchange and Solid Phase Extractions; Jeferson A. Valencia-Dávila ; Martha L. Chacón-Patiño ; Jorge A. Orrego-Ruiz ; Cristian Blanco- Tirado ; Marianny Y. Combariza ; Universidad Industrial de Santander, Bucaramanga, Santander, Colombia; Ecopetrol, Instituto Colombiano del Petróleo, Piedecuesta, Colombia New Approaches in Petroleomics:Extending the Characterization of Nitrogen in Vacuum Residue via SPE Fractionation and Analysis by ESI FT-ICR MS; Gessica Vasconcelos ; Veronica Vale Carvalho ; Carla Santos Freitas ; Lilian Valadares Tose ; Wanderson Romão ; Rosana Cardoso Pereira ; Boniek Gontijo Vaz ; Federal University of Goiás, Goiânia, GO; Federal University of Espirito Santo, Vitoria, Brazil; Petrobras, Rio de Janeiro, RJ Nitrogen Speciation in Petroleum Distillates Fractionated by SPE Using a Complementary and Powerful Approach by GC GC-NCD and FT-ICR/MS; Florian Albrieux ; Ludovic Chahen ; Lyes Assam ; Fabien Chainet ; Vincent Souchon ; IFPEN, Solaize, 6960; IFPEn, Solaize, France Asphaltene Adsorption, Aggregation and Occlusion from a High-Resolution Mass Spectrometry Point of View; Martha Liliana Chacon-Patiño, ; Marianny Yajaira Combariza ; Cristian Blanco-Tirado ; Andrea Gómez- Escudero ; Jorge A Orrego-Ruiz ; Universidad Industrial de Santander, Bucaramanga, Santander, Colombia; Ecopetrol, Instituto Colombiano del Petróleo, Piedecuesta, Colombia Petroleum Aromatic Compounds by APPI, FI, and GCEI; a Sensitivity Study; Michael T. Cheng ; Matthew Hurt ; Chevron Research, Richmond, CA Coupling of APCI / CS with Collisionally Activated Dissociation of Model Compounds for Structural Determination of Asphaltenes in Crude Oil; Mark Romanczyk ; Xueming Dong ; Hilkka Kenttämaa ; Purdue University, West Lafayette, IN; Purdue University, West Lafayatte, IN High-field FT Orbitrap MS as a Competitive Alternative for the Analysis of Complex Mixtures; Alessandro Vetere ; Wolfgang Schrader ; Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

65 MONDAY POSTERS MP MP High-Field FT Orbitrap Mass Spectrometric Investigation on Photooxidation Processes of Crude Oil; Ruoji Luo ; Wolfgang Schrader ; Max-Planck Inst für Kohlenforschung., Mülheim / Ruhr, Germany Kendrick Mass Defect Visualization of Asphaltenes Preand Post-Reaction with Bromine; Michael Spiegel ; Ian Anthony ; Matthew Brantley ; Alton Hassell ; Claire Moffett ; Subin Yoon ; Marie Stephensen ; Patrick Farmer ; Touradj Solouki ; Baylor University, Waco, TX Environmental Analysis: General (Part ) 47 MP Determination of Nitro Polycyclic Aromatic Hydrocarbons in PM.5 Using GC-MS/MS; Sun Qian ; Fan Jun ; Deng XiaoLi ; Li Yueqi 4 ; Yang Guixiang 5 ; Huang Taohong ; Yuki Hashi ; Shimadzu (China) Co., Ltd., Shanghai, shanghai; Shimadzu (China) Co., Ltd., Shanghai, China; Shimadzu (China) Co., Ltd, Shanghai, China; 4 Shimadzu (China) Co., Ltd, Beijing, China; 5 Shimadzu (China) Co., Ltd., Beijing, China MP 4 Detection of Picogram or Sub-Picogram Semi-Volatile Compounds by Full Scan GCMS Using a High Efficiency Source A Game Changer? ; Dale Walker ; Harry Prest ; Agilent Technologies, Little Falls, DE; Agilent Technologies, Santa Clara, CA MP 5 Lewisite and VX Degradation By-Product Method Development for Environmental Remediation by Liquid Chromatography/Tandem Mass Spectrometry; Stuart Willison ; Carolyn Koester ; Deon Anex ; Romy Campisano ; Terry O Neill 4 ; Sandip Chattopadhyay 5 ; Matthew Magnuson ; EPA/NHSRC, Cincinnati, OH; Lawrence Livermore National Laboratory, Livermore, CA - California; U.S. Environmental Protection Agency, Cincinnati, Ohio; 4 MRIGlobal, Kansas CIty, Missouri; 5 TetraTech, Cincinnati, OH MP 6 Atmospheric Contaminant Source Identification Using Chemometric Approaches with Mobile Membrane Introduction Mass Spectrometry (MIMS); Larissa C. Richards, ; Nicholas G Davey,,, ; Erik T Krogh ; Christopher G. Gill 4 ; Appl. Env. Res. Labs. (AERL), Nanaimo BC, Canada; University of Victoria, Victoria BC, Canada; Vancouver Island University, Nanaimo BC, Canada; 4 Appl. Env. Res. Labs. (AERL), Nanaimo, BC MP 7 In vivo Real-time Monitoring of Aphrodisiac Pheromone Release of Small White Cabbage Butterflies (Pieris rapae); Yue Li ; Robert A Mathews ; The University of Maryland, College Park, MD; Department of Entomology, Smithsonian Institution, National Museum of Natural History, Washington, D.C MP 8 Molecular Identification of Natural Organic Matter Interactions with Mercury by Ultrahigh Resolution Mass Spectrometry; Hongmei Chen ; Benjamin F Mann ; Rosalie K Chu ; Nikola Tolic ; Baohua Gu ; Oak Ridge National Laboratory, Oak Ridge, TN; Environmental Molecular Sciences Laboratory, PNNL Richland, WA MP 9 Quantification of -Hydroxypyrene in Undiluted Human Urine Samples Using Magnetic Solid-Phase Extraction Coupled with Internal Extractive Electrospray Ionization Mass Spectrometry; Hua Zhang ; Haiyan Lu ; Xiaowei Fang ; Bi-Feng Yuan ; Yu-Qi Feng ; Huanwen Chen ; East China Institute of Technology, Nanchang, China; Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, China; East China University of Technology, Nanchang, Mainland MP 0 High Throughput Detection and Identification of Chemical Excursions via GC-MS; Parminder Kaur ; Corey Stedwell ; Daniel DeBord ; st Detect Corporation, Webster, TX MP MP MP MP 4 MP 5 MP 6 MP 7 MP 8 MP 9 MP 40 MP 4 MP 4 MP 4 That s the Law : Tracking Down Trace Levels of HBCD Isomers in Recycled Polystyrene; Claude-Paul LaFrance ; Maxim Maheux ; TransBIOTech, Levis, QC; TransBIOTech, Levis, Canada Quantification of Twelve Polyfluoroalkyl Chemicals in Human Urine; Kayoko Kato ; Janice Ma ; Antonia M. Calafat ; Xiaoyun Ye ; CDC, Atlanta, GA Quantification of Triazole Biocides in Treated Wood Using Solid-Phase Extraction Coupled with Liquid Chromatography Electrospray High Resolution Mass Spectrometry; Klára Ondrušová ; Brianna Gysbers ; Alena Kubátová ; University of North Dakota, Department of Chemistry, Grand Forks Tandem GC/MS Analysis of sub-pg/μl Quantities of PBDEs, Including BDE-09 Using the Novel High Efficiency EI Source ; Stephan Baumann; Agilent Technologies, Inc., Alpharetta, GA Accurate Mass Analysis of Naphthenic Acids by Ammonia NCI; Matthew Curtis ; Stephan Baumann ; Mark Hewitt ; Richard Frank ; Dayue Shang ; Marcus Kim ; Agilent Technologies, Santa Clara, CA; Environment Canada, Burlington, Canada; Environment Canada, North Vancouver, BC Method optimization for Rapid Analysis of Brominated Flame Retardants in Polymers: with DART-Orbitrap HRAM; Antonella Guzzonato ; Olaf Scheibner ; Tabiwang Arrey ; Thomas Moehring ; Stuart Harrad 4 ; University of Birmingham, Bremen, Bremen, Bremen; Thermo Fisher Scientific, Dreieich, Germany; Thermo Fisher Scientific, Bremen, DE; 4 University of Birmingham, Birmingham, United Kingdom SIFT-MS: A Complete Real-Time Solution for Analysis of Ambient Air; Daniel B Milligan ; David Hera ; Thomas G Hughes, ; Nic Lamont, ; Vaughan S Langford ; Murray J McEwan, ; Thomas I McKellar ; Syft Technologies Ltd, Christchurch, New Zealand; University of Canterbury, Christchurch, New Zealand; University of Canterbury, Christchurch, Canterbury Determination of Trace Concentrations of Carboxylic Acids and Aldehydes in Wood Smoke Particulate Matter; Jana Rousova; University of North Dakota, Grand Forks, North Dakota Chlorinated Dioxins, Furans and Biphenyls Analysis in Complex Matrices Using Automated Extraction and Reduced Solvent Volume Column Chromatography; Rudolf Addink ; Philip Bassignani ; Toxic Report, Watertown, MA Automated Pressurized Liquid Extraction and Sample Clean Up of River Sediment in POPs Analysis; Sevag Pelanjian ; Rudolf Addink ; Toxic Report, Watertown, MA Characterization of Trihalomethanes in Meat Processing Plant Effluent; Tiffany Liden ; Doug D. Carlton ; Kevin A Schug ; University of Texas at Arlington, Arlington, TX - Texas; University of Texas at Arlington, Arlington, TX Method Development for the Identification of Novel Brominated Flame Retardants Using a Q Exactive HRAM Mass Spectrometer; Aristide P Ganci ; Tabiwang N. Arrey ; Thomas Moehring ; Stuart Harrad ; University of Birmingham, Birmingham, United Kingdom; Thermo Fisher Scientific (GmbH), Bremen, Germany Population Assessment of Perfluoroalkyl Acids (PFAAs) in the Plasma of Wild American Alligators at Kennedy Space Center, FL; Jacqueline T Bangma ; John A Bowden ; Jessica Reiner ; Russell H Lowers ; Matthew P Guillette ; Louis J Guilletter Jr. ; Medical University of South Carolina, Charleston, SC; NIST, Charleston, SC; Integrated Mission Support Service, Titusville, FL 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 65

66 GENERAL MONDAY INFORMATION POSTERS MP 44 MP 45 MP 46 MP 47 Reducing and Normalizing Matrix Effects for the Quantification of BTEX in Contaminated Soils using Ionic Liquids in HS-GC/MS; Emmanuel Varona- Torres ; Michelle Reyes ; Doug D Carlton Jr., ; Kevin A Schug, ; University of Texas at Arlington, Arlington, TX; Collaborative Laboratories for Environmental Analysis and Remediation, The University of Texas at Arlington, Arlington, TX Ultra Low-Level Detection of Perfluoroalkyl Sustances (PFASs) using LC MS/MS; Sarah Dowd ; Lauren Mullin ; Jennifer A Burgess ; Waters Corporation, Beverly, MA; Waters Corporation, Milford, MA Creation of Accurate Mass Library with GC/MS Quadrupole Data and Its Application to Higher Confidence Unknown Identification; Ming Gu ; Yongdong Wang ; Cerno Bioscience, Norwalk, CT GC-MS/MS Determination of Synthetic Musks in Human Serum; Ivana Kosarac ; Cariton Kubwabo ; Guru Prasad Katuri ; Exposure and Biomonitoring Div, Health Canada, Ottawa, ON Environmental Analysis: Pharmaceuticals and Pesticides MP 48 Mass Spectrometric Evidence of the Carbanion Reaction Intermediate in Chlordecone Environmental Decomposition; Andrei Starostine ; L Lomheim ; S. Gaspard ; E. Edwards ; University of Toronto, Toronto, ON; University of Toronto, Toronto, Canada; Universite des Antilles et de la Guyane, Pointe-a-Pitre, Guadeloupe, French West Indies MP 49 Analysis of Halogenated Environmental Contaminants in Food Products by Plasma-Assisted Reaction Chemical Ionization (PARCI); Paolo Lecchi ; Yao Lu ; Kunyu Zheng ; Peter Haferl ; Kaveh Jorabchi ; DSM Nutritional Products, Columbia, MD; Dept of Chemistry, Georgetown University, Washington, DC MP 50 MP 5 MP 5 MP 5 MP 54 MP 55 UHPLC-Liquid-EI-MS/MS Interface: A New Frontier of Multiclass Environmental Risk Factors Assessment in Sudden Infant Death Syndromes; Veronica Termopoli ; Giorgio Famiglini ; Pierangela Palma ; Achille Cappiello ; University of Urbino, Urbino, Italy Fast and Robust 0 Multi-Residue Pesticide Screening of Five Washed and Unwashed Non-Organic Berries by LC-MS/MS with Simple QuEChERS Preparation; Joshua Ye ; Frank Kero ; Craig Young ; Sharanya Reddy ; ionics Mass Spectrometry GRO, Bolton, ON; PerkinElmer, Shelton, CT A Highly Specific and Robust Multi-residue Analysis of Pesticides in Water Using Time of flight in All Ion Acquisition Mode.; Padma Marwah ; Ashok Marwah ; Sue D antonio ; Paul Zimba ; Texas A&M University, Corpus Christi, TX; Self, Corpus Christi, TX; Agilent technologies Inc, Cedar Creek, TX Multiplexed Analysis of 5 Pesticides Using Scout- MRM; Romain Carriere ; Blandine Rougemont ; Christelle Margoum ; Mathieu Le Dréau ; David Cox ; Yves J C LeBlanc ; Jerome Lemoine ; Institut des Sciences Analytiques, UMR 580 CNRS, Université de Lyon, Villeurbanne, France; IRSTEA, Villeurbanne, France; SCIEX, Concord, ON Automated Multi Residue Pesticides Analysis Using Pressurized Liquid Extraction and Gel Permeation Chromatography; Philip Bassignani ; Ruud Addink ; Fluid Management Systems, Watertown, MA Target and Not-target Screening of Pesticides and Metabolites in Paddy Water; Eleonora Mazzucco ; Fabio Gosetti ; Bianca Bolfi ; Marcello Manfredi ; Arianna Facchi 4 ; Marco Romani 5 ; Simone Silvestri 5 ; Elisa Robotti ; Emilio Marengo ; università Del Piemonte Orientale, MP 56 MP 57 MP 58 MP 59 MP 60 MP 6 MP 6 MP 6 MP 64 MP 65 Alessandria, Alessandria; University of Piemonte Orientale, Alessandria, IT; ISALIT-DISIT, University of Piemonte Orientale, Alessandria, IT; 4 Dipartimento di Scienze Agrarie e Ambientali, Università degli Studi di Milano, Milano, IT; 5 Ente Nazionale Risi, Pavia, IT Rapid and Easy Comparison of Quechers Sample Preparation Methods for the Analysis of Pesticide Residues In Pear Using LC-ESI-QQQ; Victor Manuel Mondragon Olguin ; Jose Luis Freire ; Agilent technologies Inc, Mexico, DF Comprehensive, Sensitive, and Quantitative Screening of Pesticides in Selected Swiss Headwater Catchments by an Online-SPE-LC-Orbitrap Method; Heinz Singer ; Rahel Comte ; Simon Mangold ; Christioph Moschet ; Christian Stamm ; Tobias Doppler ; Irene Wittmer ; Eawag, Duebendorf, CH; Eawag, Duebendorf, Switzerland LC-MS/MS Method Development and Validation for the Quantification of LB-00 and Endothall Metabolite in Biological Matrices; Changyu Quang ; Jennifer L. Simko ; William C Nethero ; Elizabeth A Groeber ; John S Kovach ; WIL Research, Ashland, OH; Lixte Biotechnology Holdings, Inc., East setauket, NY Ultra-Sensitive and Rapid Assay of Neonicotinoids, Fipronil and Some Metabolites in Honey by UHPLC- MS/MS.; Mikael Levi ; Aurore Jaffuel ; Stephane Moreau ; shimadzu France, Noisiel, France; Shimadzu Europe GmbH, Duisburg, Germany Parts-per-trillion (ppt) Level High-Throughput Quantitation of Glyphosate, Aminomethylphosponic Acid (AMPA) and Glufosinate in Water Samples by LC- MS/MS; Javier Lopez ; Miguel Angel Perez ; Carsten Baessmann ; Louis Maljers ; Joe Anacleto 4 ; Bruker Espanola, S.A., Madrid, Spain; Bruker Daltonik GmbH, Bremen, -; Bruker, Fremont, CA; 4 Bruker Ltd., Milton, Canada Direct Analysis of Formulated Pesticide Product Matrices by Paper Spray Mass Spectrometry; Khang To ; Steven L Reeber ; Gary Glish ; University of North Carolina Chapel Hill, Chapel Hill, NC Human Biomonitoring for Pesticide Exposure and Effects on Metabolism using Convergence Chromatography-Mass Spectrometry; Zdenek Spacil ; Garry Codling ; Petra Booij ; Jana Klanova ; Masaryk University, Brno, Czech Republic Multiresidue Determination of non-hplc-esi-ms- Amenable Organochlorine Pesticides with Liquid Chromatography Dielectric Barrier Discharge Ionization Mass Spectrometry (LC-DBDI-TOFMS); José Robles- Molina ; Felipe J Lara-Ortega ; Bienvenida Gilbert-López ; Antonio Molina-Díaz ; Juan F Garcia-Reyes ; Alexander Schutz 4 ; Sebastian Brandt 4 ; Joachim Franzke 4 ; University of Jaen, JAEN, ES; CSIC-CIAL, Madrid, ES; University Of Jaen, Jaen, Andalucia; 4 Leibniz-Institut für Analytische Wissenschaften, Dortmund, Germany An Unknown Screening Approach to Analyze Micropollutants Degradation by Different Disinfection Processes; Julia Quilitzki ; Patricia van Baar ; Uwe Dünnbier ; Olaf Scheibner ; Berliner Wasserbetriebe, Berlin, Germany; Thermo Fisher Scientific, Bremen, Germany Removal and Transformation of Persistent Emerging Contaminants via Advanced Oxidation Techniques; Kristin Cochran ; Jorge Casado ; Susan Richardson ; Dionysios Dionysiou ; Daniel Schlenk 4 ; Gianluca Li Puma 5 ; Danilo Russo 6 ; Danilo Spasiano 6 ; Marianna Vaccaro 6 ; Roberto Andreozzi 6 ; Nuno Reis 5 ; Raffaele Marotta 6 ; University of South Carolina, Columbia, SC; Universal Diagnostics SL, Seville, Spain; University of Cincinnati, Cincinnati, Ohio; 4 University of California, Riverside, Riverside, CA; 5 Loughborough University, Loughborough, PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

67 MONDAY POSTERS MP 66 MP 67 MP 68 MP 69 MP 70 MP 7 MP 7 MP 7 MP 74 MP 75 MP 76 United Kingdom; 6 University of Naples Federico II, Naples, Italy Quantitation and Identification of Legal and Illicit Drugs in Wastewater in the Low ng/l Range using Large- Volume Injection and LC-MS/MS; Paul Winkler ; Andre Schreiber ; Michael Scherer ; SCIEX, Redwood City, CA; SCIEX, Concord, ON; Sciex Switzerland, Rotkreuz, Switzerland Sensitive Screen of Pharmaceuticals and Personal Care Products (PPCPs) in Water Using Agilent 6545 LC/Q-TOF High Resolution Mass Spectrometer; Dan-Hui Dorothy Yang ; Craig Marvin ; mark Murphy ; Yue Song 4 ; Jimmy Chan 4 ; Agilent Technologies, Santa Clara, CA; Agilent Technologies, Wilmington, DE; EPA, Golden, CO; 4 Agilent, Shanghai, China Non-Target Screening using Liquid Chromatography Coupled to High Resolution MS/MS (LC-HR-MS/MS) Identification of Unknown Environmental Pollutants; Andre Schreiber ; KC Hyland ; Paul Winkler ; SCIEX, Concord, ON; Sciex, Redwood City, CA LCMS-MS Method for Evaluation of PPCPs in Environmental Water; Katie M Pryor ; Jerry Byrne II ; Rachel Lieberman ; Jeremy Post ; Christopher Gilles ; Shimadzu Scientific Instruments, Columbia, MD LC TOF-MS and GC MS Analysis of Pharmaceuticals and Personal Care Products in Wastewaters of Eastern North Carolina; Blake Rushing ; Ashley Wooten ; Marcus Shawky ; Mustafa Selim ; East Carolina University, Greenville, NC Analysis of Potential Genotoxic Impurities (PGI) in Active Pharmaceutical Ingredients (API) by GCMS/MS; Prashant Hase ; Ankush Bhone ; Durvesh Sawant ; Dheeraj Handique ; Sanket Chiplunkar ; Ajit Datar ; Jitendra Kelkar ; Pratap Rasam ; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, Maharashtra; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, India Combining Commercial and Open-Source Accurate Mass MS/MS Library Information for Suspect and Non-Target Screening Workflows; Sascha Lege ; Thomas Glauner ; Thierry Faye ; Craig Marvin 4 ; Christian Zwiener ; Eberhard Karls University Tuebingen, Tuebingen, Germany; Agilent Technologies Sales&Services GmbH, Waldbronn, Germany; Agilent Technologies, Paris, France; 4 Agilent Technologies, Wilmington, DE Increased Throughput in the Determination of PPCPs in Water Using Optimized MS Cycle Times in a High Sensitivity UHPLC-QQQ System; Behrooz Zekavat ; Thomas Glauner ; Craig Marvin ; André Santos ; Tarun Anumol ; Jerry Zweigenbaum ; Agilent Technologies, Santa Clara, CA; Agilent Technologies, Little Falls, DE Fates of Known and Unknown Compounds from Full Scale Ozone and Activated Carbon Adsorption Process Using High Resolution MS; Jaewon Choi ; Wonseok Choi ; Hyunji Jang ; Ilhwan Choi ; Yuns Kim ; Charles Yang ; Dipankar Ghosh ; Kwater, Daejeon, South Korea; Thermo Fisher Scientific, San Jose, CA Extraction of Organochlorine Pesticides with In-line Florisil Cleanup using an Acid-Base-Neutral Solid Phase Extraction System; Phil Germansderfer ; Ruud Addink ; Fluid Management Systems, Watertown, MA One Step Extraction, Cleanup and Concentration of Chlorinated Pesticides in Raw Coffee Beans; Rashid Juma ; Ruud Addink ; Fluid Management Systems, Watertown, MA MP 77 MP 78 MP 79 MP 80 MP 8 MP 8 MP 8 MP 84 MP 85 Epigenetic Modifications Improving Quantitative Analysis of Modified DNA Nucleosides by Liquid Chromatography-Triple- Quadrupole Mass Spectrometry; Nan Dai ; Shengxi Guan ; Jeremy Foster ; Ivan R. Corrêa ; New England Biolabs, Ipswich, MA; New Englanb Biolabs, Ipswich, MA Quantitative Histone Mass Spectrometry Identifies Elevated Histone H Lysine 7 Trimethylation in Melanoma; Lauren Davis ; Deepanwita Sengupta ; Stephanie Byrum ; Nathan Avaritt ; Bradley Shields ; Fade Mahmoud ; Matthew Reynolds ; Lisa Orr ; Samuel Mackintosh ; Sara Shalin ; Alan Tackett ; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Science, Little Rock, AR; Department of Hematology Oncology and Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR Mass Spectrometric Profiling of Histone Proteins and Their Modifications in the Biofuel-Producing Microalgae Chlamydomonas Reinhardtii; Carlo K Eikani ; Aliyya Khan ; Anthony T Iavarone ; James J Pesavento ; Department of Biology, Saint Mary s College of California, Moraga, CA; QB/Chemistry Mass Spectrometry Facility, University of California, Berkeley, Berkeley, CA Characterization of Histone H4 Post-translational Modification in the Microalgae Chlamydomonas Reinhardtii by Top Down Mass Spectrometry; Aliyya Khan ; Carlo K Eikani ; Anthony T Iavarone ; James J Pesavento ; Department of Biology, Saint Mary s College of California, Moraga, CA - California; QB/Chemistry Mass Spectrometry Facility, University of California, Berkeley, CA Systems Level Analysis of Histone H Post- Translational Modifications Reveals Features of PTM Crosstalk in Chromatin Regulation; Veit Schwämmle ; Simone Sidoli ; Chrystian Ruminowicz ; Xudong Wu, 4 ; Chung-Fan Lee ; Kristian Helin ; Noerregaard Ole Jensen ; University of Southern Denmark, Odense, Denmark; University of Pennsylvania, Philadelphia, PA; University of Copenhagen, Copenhagen, Denmark; 4 Tianjin Medical University, Tianjin, China Utilizing Mass Spectrometry-Based Targeted Quantitative Proteomics to Determine the Factors that Alter the Specificity of Lysine Acetyltransferases; Yin- Ming Kuo ; Ryan A Henry ; Andrew J Andrews ; Fox Chase Cancer Center, Philadelphia, PA Understanding the Origin and Evolution of the Epigenetic Code of Histones with an Orbitrap Fusion Lumos; Arnau Sebé-Pedrós ; Cristina Chiva, ; Bernat Serra-Vidal, ; Iñaki Ruiz-Trillo 4 ; Eduard Sabidó, ; Weizmann Institute of Science, Rehovot, Israel; Proteomics Unit, Centre de Regulació Genòmica (CRG), Barcelona, SPAIN; Proteomics Unit, Universitat Pompeu Fabra (UPF), Barcelona, Spain; 4 Institut de Biologia Evolutiva, Universitat Pompeu Fabra-CSIC, Barcelona, Spain Proteolytic Processing of Histone HA by the Cathepsin L Protease; Mariel Coradin ; Benjamin A Garcia ; University of Pennsylvania, Philadelphia, U.S.; University of Pennsylvania, Philadelphia, PA Introducing Epigenomics in Systems Biology: Cross- Talk between Cell Signal Transduction and Epigenetic Mechanisms; Simone Sidoli ; Pau Pascual Garcia ; Katarzyna Kulej, ; Brian Debo ; Maya Capelson ; Benjamin A. Garcia ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; The Children s Hospital of Philadelphia, Philadelphia, PA 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 67

68 GENERAL MONDAY INFORMATION POSTERS MP 86 MP 87 MP 88 MP 89 MP 90 MP 9 MP 9 MP 9 MP 94 Turnover Profiles of Histone Post-Translational Modifications in a Myogenic Model Using SILAC Labeling, Enzyme Networks and Trend Clustering Analysis; Natarajan Bhanu ; Simone Sidoli ; Benjamin A Garcia ; University of Pennsylvania, Philadelphia, PA Middle-Down Characterization of Histone H4 Combinatorial Post-Translational Modification Codes for Breast Cancer Invasion; Tingting Jiang ; Yu Chen ; Michael E Hoover ; Christopher L Hendrickson, 4 ; Michael A Freitas ; Alan G Marshall, 4 ; Nicolas L Young 5 ; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL; The Roy J. Carver Biotechnology Center University of Illinois at Urbana-Champaign, Urbana, IL; Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH; 4 Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, FL; 5 Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX LC-MS/MS for the Sensitive Quantification of 5-Methylcytidine in RNA; Gwendolyn Gonzalez ; Lijuan Fu ; Yinsheng Wang ; University of California - Riverside, Riverside, CA - California Less is More: Single-Neuron Epitranscriptomics using a Tandem Mass Spectrometric Approach; Maria Basanta-Sanchez ; Andrea B. Kohn ; Lenka Halamkova, 4 ; Igor K. Lednev 5 ; Leonid L. Moroz, 6 ; The RNA Institute, University at Albany, Albany, NY; The Whitney Laboratory for Marine Bioscience, St. Augustine, FL; The RNA Institute, University at Albany Albany, NY; 4 The RNA Institute, Albany, NY; 5 The RNA Institute University at Albany, Albany, NY; 6 Department of Neuroscience and McKnight Brain Institute, University of Florida, Gainesville, FL Contributions of Quantitative Histone PTM Analysis to Target Discovery, Compound Triage, and in vivo Experiments into Epigenetic Drug Tolerance; Tommy K. Cheung ; Tobias Maile ; Erin McNamara ; Feng Zhao ; Patrick Trojer ; Lesley Murray ; Marie Classon ; David Arnott ; Genentech Inc, South San Francisco, CA; Constellation Pharmaceuticals, Cambridge, MA Quantitation of Post-Translational Modifications in the Nucleus: Effects of Histone Modifying Enzymes on their Histone and Non-Histone Substrates; Anastasia Lindahl ; Michael Smallegan ; Josue Baeza ; James Dowell ; Kimberly A Krautkramer ; John M Denu ; UW- Madison, Madison; University of Wisconsin Madison, Madison, Wisconsin; Univ of Wisconsin, Madison, WI in vitro Characterization of Histone Acyl- Posttranslational Modifications Using LC-MS; Johayra Simithy ; Simone Sidoli ; Zuo-Fei Yuan ; Benjamin A Garcia ; University of Pennsylvania, Philadelphia, PA Probing the UV-Induced Effects on RNA and RNA- Modifications by LC-MS; Congliang Sun ; Zalfa Abdel- Malek ; Kazumasa Wakamatsu ; Limbach A Patrick ; Balasubrahmanyam Addepalli ; University of Cincinnati, Cincinnati, Ohio; Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan Parallel Reaction Monitoring Mass Spectrometry for Histone H Modification Analysis of Differentiating MEL cells; Michael Sweredoski ; Annie Moradian ; Matthias Raedle ; Sonja Hess ; California Institute of Technology, Pasadena, CA; Hochschule Weihenstephan-Triesdorf, Weihenstephan-Triesdorf, Germany; Caltech, Pasadena, CA MP 95 MP 96 MP 97 MP 98 MP 99 MP 00 MP 0 MP 0 MP 0 MP 04 MP 05 MP 06 High Mass Accuracy/High Performance MS Applications 95-0 HRAM LC/MS Screen for Prostaglandins found in Consumer Products; Bethany Hanson ; Toomey Valerie ; FDA/Forensic Chemistry Center, Cincinnati, OH Quantitation of Potential Genotoxic Impurities in Active Pharmaceutical Ingredients, Drug Products, and Process Intermediates by High Resolution LC-MS; Robert Menger ; James Winter ; Alwyn Forbes ; Andy Lo ; Peng Wang ; Shannon Higgins-Gruber ; Ed Bishop ; Naijun Wu ; Celgene, Summit, NJ Determination of Chemical Components of KABA Meteorite by LDI and ESI Ionization Methods Using a 5T FT-ICR Instrument; Arpad Somogyi ; Mihaly M. Nagy ; Jozsef Posta ; Ohio State University, Colombus, OH; High School of Protestant College, Debrecen, Hungary; University of Debrecen, Debrecen, Hungary Origin Discrimination of Red Pepper Powder Using UHPLC-Q-Oribitrap HRMS with Multivariate Analysis; Dong-Jin Kang ; Ji-Young Moon ; Seong-Hun Lee ; Experimental Research Institute, NAQS Gimcheon-si, Korea Orbitrap Fusion Tribrid Mass Spectrometer for Pharmaceutical Impurity Analysis; Kate Comstock ; Caroline Ding ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, San Jose, CA MALDI spiral-tofms and Kendrick Mass Defect Analysis of Mycolic Acids from Bacteria which Accelerate the Formation of Antibiotics; Kanae Teramooto ; Shumpei Asamizu ; Taro Ozaki ; Katsuya Satoh ; Hiroyasu Onaka ; Robert Cody 4 ; JEOL Ltd., Akishima, Tokyo; The University of Tokyo, Bunkyo, Tokyo, Japan; Japan Atomic Energy Agency, Takasaki, Japan; 4 JEOL USA Inc., Peabody, MA Top-down analysis of Calmodulin and Lysozyme Using MS/DMS on an FT-ICR MS; Federico Floris ; Maria van Agthoven ; Lionel Chiron ; Mark P Barrow ; Marc-André Delsuc, ; Peter B O Connor ; University of Warwick, Coventry, United Kingdom; C4SC4DE, Illkirch- Graffenstaden, France; IGBMC, Illkirch-Graffenstaden, France Characterization of Impurities ofhiv NNRTI Doravirine by High Resolution UPLC-MS and Tandem MS Analysis; Li-Kang Zhang; Merck Research Laboratories, Kenilworth, NJ Prospecting for Aqueous Gold Clusters [7.6-kDa Au44(pMBA)60, 6.8-kDa Au0(pMBA)44] using a High-Resolution Extended-Mass-Range(EMR) Orbitrap MS; Marcos Alvarez ; German Plascencia-Villa ; Wendell P. Griffith ; David M. Black ; Miguel José Yacamán ; Jenny Chen ; Robert Loyd Whetten ; University of Texas at San Antonio, San Antonio, TX; Thermo Fisher Scientific, San Jose, CA Increased Identification of Extractables and Leachables Compounds by the Use of Chemical Ionization and Custom Databases; Syed Salman Lateef ; Siji Joseph ; Ravindra Gudihal ; Agilent Technologies India Pvt. Ltd, Bangalore, India Molecular Depth Profiling with a New Hybrid D SIMS Instrument for Improved Molecular Identification; Alexander Pirkl ; Rudolf Moellers ; Henrik Arlinghaus ; Ewald Niehuis ; Alexander Makarov ; Stevan Horning ; Rasmus Havelund ; Melissa Passarelli ; Alex Shard ; Ian Gilmore ; ION-TOF GmbH, Muenster; Thermo Fisher Scientific, Bremen, Germany; National Physical Laboratory, Teddington, United Kingdom LC-Quadrupole/Orbitrap MS/HRMS Enables Stable Isotope Resolved Simultaneous Quantification and Metabolic Isotope Tracing of Acyl-Coezyme A Species; PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

69 MONDAY POSTERS MP 07 MP 08 MP 09 MP 0 MP MP MP MP 4 MP 5 Nathaniel W Snyder ; Alexander J Frey ; Sophie Trefely ; Daniel R Feldman ; Andrew J Worth ; Basu S Sankha ; Drexel University, Philadelphia, PA; Bristol-Myers Squibb Pharmaceutical Candidate Optimization, Wallingford, CT; Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Quantitative Evaluation of Immunosuppressant Drugs by High Resolution Accurate Mass using Selected Ion Monitoring Analysis; Keeley Murphy ; Jonathan L Josephs ; Maciej P Bromirski ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Bremen, DE Parallel Untargeted and Targeted Quantitative Metabolomics for Microbiome Research; Alexey V. Melnik ; Fernando Vargas ; Amina Bouslimani ; Ivan Protsyuk ; Theodore Alexandrov,, ; Pieter C. Dorrestein, 4 ; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany; SCiLS GmbH, Bremen, Germany; 4 Departments of Chemistry, Biochemistry and Pharmacology, University of California, San Diego, CA Simultaneous Determination of Phthalic Acid Esters, Organotins, Perfluorochemicals and Flame Retardants in Plastics by HPLC-LTQ/Orbitrap Mass Spectrometry; Li Zhang ; Xin Luo ; Zengyuan Niu ; Xiwen Ye ; Zhixu Tang ; Shuwei Xia ; Ocean University of China, Qingdao, China; Shandong Entry-Exit Inspection and Quarantine Bureau, Qingdao, China Acceptance Criteria for Confirmation of Identity of Chemical Residues Using Exact Mass Data; Hiranthi Jayasuriya ; Philip K Kijak ; Sherri Turnipseed ; Timothy R Croley ; Jon Wong ; Bryan Gamble 4 ; Hui Li ; Center for Veterinary Medicine, FDA, Laurel, MD; Animal Drug Research Center, Denver, Colorado; CFSAN, U.S. FDA College Park, MD; 4 Forensic Chemistry Center, Cincinnati, OH Imaging MS: Instrumentation - Topographical and Chemical Imaging Using a Combined Atomic Force Microscopy/Infrared Spectroscopy/Mass Spectrometry Platform; Vilmos Kertesz ; Tamin Tai ; Orsolya Karacsony ; Vera Bocharova ; Kevin Kjoller ; Gary J Van Berkel ; Oak Ridge National Laboratory, Oak Ridge, TN; Anasys Instruments, Santa Barbara, CA Development of Nanopipettes as Probes for Scanning Electrospray Microscopy (SESM); Elizabeth M Yuill ; Wenqing Shi ; John Poehlman ; Lane A Baker ; Indiana University Dept. Chemistry, Bloomington, IN A Reflectron Microscope-Mode Imaging Mass Spectrometer Capable of Achieving High Mass Resolution; Ang Guo ; Michael Burt ; Robert Burleigh ; Steve Thompson ; Mark Brouard ; University of Oxford, UK Oxford, United Kingdom; Scientific Analysis Instruments, Manchester, UK Combining Scanning Ion Conductance Microscopy and Nanospray Desorption Electrospray Ionization Mass Spectrometry for Multimodal Ambient Imaging of Biological Samples; Julia Laskin ; Son N Nguyen ; Venkateshkumar Prabhakaran ; Andrey Liyu ; Ruichuan Yin ; Pacific Northwest National Lab, Richland, WA Combining Imaging Mass Spectrometry with Infrared Spectromicroscopy Screening: A New Approach to Studying Biological Tissues; Antoine Masson ; Matthew J DiTucci ; Anna Susa ; Jeremy T O Brien ; Evan R Williams, ; Hoi-Ying holman ; Lawrence Berkeley National Lab, Berkeley, CA; University of California, Berkeley, CA MP 6 MP 7 MP 8 MP 9 MP 0 MP MP MP MP 4 MP 5 MP 6 MP 7 Ambient Submicron Mass Spectrometry Imaging by Combining AFM with MS; Jonathan Brauer ; Jacob Berenbeim ; Mattanjah de Vries ; Anasys Instruments, Santa Barbara, CA; University of California Santa Barbara, Santa Barbara, CA Microscope Ion Imaging of Complex Surfaces Using the Pixel Imaging Mass Spectrometry Camera; Robert J Burleigh ; Ang Guo ; Edward Halford ; Michael Burt ; Steve P Thompson ; Mark Brouard ; University of Oxford, Oxford, UK; Scientific Analysis Instruments, Manchester, UK Development of Laser Capture Microdissection- Liquid Vortex Capture ESI-MS (LMD-LVC/ESI-MS) for Quantitative and Sub-Micrometer Mass Spectral Surface Sampling and Imaging; John F. Cahill ; Vilmos Kertesz ; Gary J Van Berkel ; Oak Ridge National Laboratory, Oak Ridge, TN Liquid Extraction Surface Analysis (LESA) Combined with Nano-Liquid Chromatography (nlc) for In-Depth Analysis of Biological Surfaces; Daniel Eikel ; Terry Wilper ; Karen Norton ; Eric Solon ; Sara Savage ; Simon J Prosser ; Advion, Inc. Ithaca, NY; Sanofi-Genzyme, Framingham, MA; QPS, Newark, DE Transmission Geometry MALDI Imaging MS: Assessing Ion Generation/Collection Efficiency at Sub-micron Laser Spot Sizes; Andre Zavalin ; Junhai Yang ; Richard M Caprioli ; Vanderbilt University, Nashville, TN Desorption Electrosonic Spray Ionizationfor Ambient Mass Spectrometry Imaging; Shuai Guo ; Zhili Li ; Institute of Basic Medical Sciences, CAMS & PUMC, Beijing, CN; IBMS, CAMS&PUMC, Beijing Improved Reproducibility in MALDI Imaging using a Scanning Laser Beam; Dagmar Niemeyer ; Michael Becker ; Shannon D Cornett ; Paul J Kowalski ; Jane-Marie Kowalski ; Sören-Oliver Deininger ; Bruker Daltonik GmbH, Bremen, Germany; Bruker Daltonics, Inc., Billerica, MA Laser Ablation Electrospray Ionization Mass Spectrometry Imaging (LAESI-MSI) Using an Er:YAG Laser for Improved Spot Size Resolution and Tunable Ablation; Matthew Powell ; Trust T Razunguzwa ; Holly Henderson ; Heather Anderson ; Nicholas J. Morris ; Todd W. Ornduff ; David W. DuBois ; Protea Biosciences, Inc. Morgantown, WV D nanosims: A Novel High-Mass Resolution Instrument for D Molecular Imaging with Sub-Micron Resolution; Melissa K. Passarelli ; Alexander Pirkl ; Rudolf Moellers ; Ewald Niehuis ; Alexander A Makarov ; Henrik Arlinghaus ; Rasmus Havelund ; Paulina D. Rakowska ; Alan M. Race ; Alex Shard ; Andy West 4 ; Stevan Horning ; Peter S. Marshall 4 ; Morgan R. Alexander 5 ; Colin Dollery 4 ; Ian Gilmore 6 ; National Physical Laboratory, Teddington, United Kingdom; ION-TOF GmbH, Muenster, Germany; Thermo Fisher Scientific, Bremen, DE; 4 GlaxoSmithKline, Stevenage, UK; 5 The University of Nottingham, Nottingham, UK; 6 National Physical Laboratory, Teddington, Middlesex Development of a Time and Position Sensitive Ion Detector for a Stigmatic Imaging Mass Spectrometer; Jun Aoki ; Yosuke Kawai ; Yowichi Fujita ; Hisanao Hazama ; Toshinobu Hondo ; Kunio Awazu ; Michisato Toyoda ; Yasuo Arai ; Osaka University, Toyonaka, Japan; High Energy Accelerator Research Organization, Tsukuba, Japan; Osaka University, Suita, Japan Three Micron Resolution MALDI-MS Imaging Without Transmission Geometry or Oversampling and Its Application to Maize Root Cross-section; Adam Feenstra, ; Young-Jin Lee, ; Ames Laboratory-US DOE, Ames, Iowa; Iowa State University, Ames, IA Rapid Laser Desorption Imaging MS with Submicron Spatial Resolution; Jerome Moore ; J Albert Schultz ; Valerie Steen ; Robot Nose, Lemont, IL; Ionwerks, Inc. Houston, TX 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 69

70 GENERAL MONDAY INFORMATION POSTERS MP 8 MP 9 MP 0 MP DESI Imaging at Varying Acquisition Rates with Real Time Imaging Display for Optimized Tissue Imaging; Emrys Jones ; Mark Towers ; Bindesh Shrestha ; Philiipa Hart ; Richard Chapman ; Emmanuelle Claude ; Waters Corporation, Wilmslow, UK; Waters Corporation, Beverly, Massachusetts Automated High Throughput D Imaging Using Desorption Electrospray Ionisation Mass Spectrometry; Emrys A Jones, ; Lukasz Migas ; Richard Chapman ; Emmanuelle Claude ; James Langridge ; Steven D Pringle ; Zoltan Takats 4 ; Mike Morris ; Imperial College London, London, Greater London; Waters Corporation, Wilmslow, UK; University of Manchester, Manchester, UK; 4 Imperial College, London, United Kingdom Maximizing Performance of Spatial Proteomics through the Fusion of Ultra-High Speed MALDI-TOF and High,, Mass Resolution MALDI FTICR IMS; Jeffrey Spraggins, 4 ; Raf Van de Plas, 4, 5 ; Jessica L Moore, 4 ; Daniel Ryan, 4 ; Richard M Caprioli,, 4, 6 ; Vanderbilt University, Nashville, TN; Vanderbilt Dept. of Biochemistry, Nashville, TN; Vanderbilt Dept. of Chemistry, Nashville, TN; 4 Vanderbilt University MSRC, Nashville, TN; 5 Delft University of Technology, Delft, Netherlands; 6 Vanderbilt University School of Medicine, Nashville, TN Localization and Identification of Peptides from Tissue Using High-Speed MALDI TOF/TOF Mass Spectrometry; Michael Becker ; Anja Resemann ; Janine Beckmann ; Julian Langer, ; Rainer Paape ; Detlev Suckau ; Bruker Daltonik GmbH, Bremen, Germany; Max-Planck-Institute for Biophysics, Frankfurt Am Main, Germany; Max-Planck- Institute for Brain Research, Frankfurt Am Main, Germany MP 8 MP 9 MP 40 MP 4 MP 4 MP 4 University, Ambler, PA; Drexel University, Philadelphia, PA A Combined Enzymatic Digestion and Matrix Application Approach for High Throughput MSI of FFPE Tissue; Haddon E. Goodman ; Erin H. Seeley ; Protea Biosciences, Morgantown, WV Utilization of Soft-landing Ion Mobility for the Deposition of Clusters as Matrix Substitutes for Matrix-assisted Laser Desorption/Ionization Mass Spectrometry Imaging; Roberto Aguilar ; Guido F Verbeck ; University of North Texas, Denton, TX Optimal Sample Preparation Method for Visualizing Global Endogenous Metabolites by Mass Spectrometry Imaging in Arabidopsis; Tomomi Ichinose ; Yoshinori Fujimura ; Shuichi Nakaya ; Yuzo Yamazaki ; Junya Nakamura ; Eisuke Hayakawa ; Hiroyuki Wariishi ; Daisuke Miura ; Kyushu University, Fukuoka, Japan; Shimadzu Corporation, Kyoto, Japan Investigation into the use of Tissue Washing Procedures and the Subsequent Outcomes for DESI- MS Imaging Analyses; Philippa Hart ; Mark Towers ; Emmanuelle Claude ; Waters Corporation, Wilmslow, UK Investigation of Aging of Chemically Fixed Mammalian Cells via ToF-SIMS; Julia Kokesch-Himmelreich ; Daniel J Graham ; Lara J Gamble ; University of Washington, Seattle, WA Mass Spectrometry Imaging to Better Understand the Mycoparasitic Interaction of Biocontrol Agents; Matthias Holzlechner ; Zoratto Samuele ; Reitschmidt Sonja ; Zeilinger Susanne, ; Martina Marchetti-Deschmann ; Vienna University of Technology, Vienna, Austria; University of Innsbruck, Innsbruck, Austria; Vienna University of Technology, Vienna, Vienna MP MP MP 4 MP 5 MP 6 MP 7 Imaging MS: Sample Preparation - 4 Analyzing the Effect of Cocaine on Lipid Localization in Drosophilabrain Tissue Using Secondary Ion Mass Spectrometry Imaging; Mai Hoang ; Nhu Phan ; Per Malmberg ; Andrew G Ewing, ; Chalmers University of Technology, Goteborg, Sweden; Goteborg University, Goteborg, Sweden Improvement of Peptides Imaging on Tissue by Supercritical Fluid Wash of Lipids for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry; Shoko Matsushita ; Noritaka Masaki ; Kohei Sato ; Takahiro Hayasaka ; Eiji Sugiyama ; Shu-Ping Hui ; Hitoshi Chiba ; Nobuyuki Mase ; Mitsutoshi Setou ; Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Applied Chemistry and Biochemical Engineering, Faculty of Engineering, Shizuoka University, Hamamatsu, Japan; Health Innovation and Technology Center, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan Ammonium Sulfate Improves Detection of Hydrophilic Quaternary Ammonium Compounds through Decreased Ion Suppression in Matrix-Assisted Laser Desorption/ Ionization Imaging Mass Spectrometry; Eiji Sugiyama ; Noritaka Masaki ; Shoko Matsushita ; Mitsutoshi Setou ; Hamamatsu University School of Medicine, Hamamatsu, Shizuoka Systematic Assessment of Surfactants for MALDI Imaging Mass Spectrometry; Bijay Banstola ; Fabrizio Donnarumma ; Fan Cao ; Eulalie T Grodner ; Kermit K Murray ; Louisiana State Univeristy, Baton Rouge, LA High Performance Matrix Pre-coated Targets for MALDI Imaging of Lipids; Junhai Yang ; Richard M Caprioli ; Vanderbilt University, Nashville, TN Using MALDI Depth Profiles to Understand the Effect of ESD Sample Preparation Parameters on MALDI IMS Samples; Brian James Malys ; Kevin G Owens ; Drexel MP 44 MP 45 MP 46 MP 47 MP 48 MP 49 Imaging MS: Software High-Performance Visualization and Multivariate Analysis Software for Mass Spectrometric Imaging; Daichi Yukihira ; Mitsuhiro Kanazawa ; Reifycs Inc., Tokyo, Japan Finding Patterns in Mass Spectrometry Images; Daniel Graham ; Lara J Gamble ; University of Washington, Seattle, WA Software for Distributed MALDI Imaging Workflows; Stefan Frehse ; Fingal Orlando Galashan ; Tobias Boskamp, ; Jan Hendrik Kobarg ; Stefan Schiffler ; Klaus Steinhorst ; Janina Oetjen ; Carl Evertsz ; Theodore Alexandrov,, 4 ; Peter Maass, ; Dennis Trede ; SCiLS GmbH, Bremen, Germany; University of Bremen, Bremen, Germany; EMBL Heidelberg, Heidelberg, Germany; 4 University of California, San Diego La Jolla, CA Absolute Quantification and Customizable Database Integration for Molecular Identification with MSiReader; Kenneth Garrard ; Mark T Bokhart ; Milad Nazari ; David C Muddiman ; North Carolina State University, Raleigh, NC Translational Data Analytics for Large Mass Spectrometry Imaging Datasets in Clinical Research; Kirill Veselkov ; Mirnezami Reza ; Emmanuelle Claude ; James Kinross ; James McKenzie ; Paolo Inglese 4 ; Kieran Neeson ; James Langridge 5 ; Elaine Holmes 4 ; Zoltan Takats ; Jeremy K Nicholson ; Imperial College, London, London; Imperial College, London, UK; Waters, Wilmslow, United Kingdom; 4 Imperial College, London, United Kingdom; 5 Waters, Manchester Characterization of Data-driven Image Fusion for Imaging MS: Exploring Image Modality Combinations that Maximize Predictive Performance for Distinct Biomolecular Classes; Raf Van de Plas, ; Jeffrey Spraggins ; Nico Verbeeck ; Junhai Yang ; Richard M Caprioli ; Delft University of Technology, Delft, Netherlands; Vanderbilt University, Nashville, TN PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

71 MONDAY POSTERS MP 50 MP 5 MP 5 MP 5 MP 54 MP 55 MP 56 MP 57 MP 58 MP 59 MP 60 Informatics: Metabolomics IFrID: A Novel In-Source Fragmentation Detection and Deconvolution Algorithm for LC-MS Metabolomics Data; Tytus Mak ; Maryam Goudarzi ; Stephen Stein ; National Institute of Standards and Technology, Gaithersburg, MD; Georgetown University Medical Center, Washington, DC Exploring Spectral Relationships and Peak Redundancy in API Mass Spectra; Nathaniel Mahieu ; Gary J Patti ; Washington University in St. Louis, St. Louis, MO Accurate Mass Retention Time Locked Metabolomics EI Library and Workflows for Accurate Mass GC/Q-TOF Metabolomics Data Processing; Sofia Nieto ; Zijuan Lai ; Mine Palazoglu ; Hong Chen ; Aditi Koul ; Vadim Kalmeyer ; Oliver Fiehn ; Agilent technologies Inc, Santa Clara, CA; UC Davis, Davis, CA Rapid MS Formulae to Isotope Pattern Matching Using a Novel MS Search Engine for Metabolomics; Scott Walmsley, ; Hyungwon Choi ; Samantha Bokatzian ; Richard Reisdorph ; Nichole A Reisdorph ; Dept. of Pharmaceutical Sci., University of Colorado Denver- Anschutz, Aurora, Colorado [CO]; UCD Computational Biosciences Program, Aurora, Colorado [CO]; National University of Singapore, Singapore, Singapore Optimus + `ili: Software for LC-MS Based Spatial Metabolomics in D, D, and Virtual Reality; Ivan Protsyuk ; Sergey Ryazanov ; Garg Neha ; Tal Luzzatto- Knaan ; Amina Bouslimani ; Clifford Kapono ; Alexey Melnik ; Dimitri Floros ; Luca Rappez ; Prasad Phapale ; Pieter Dorrestein ; Theodore Alexandrov, ; EMBL, Heidelberg, Germany; Skaggs School of Pharmacy, UC San Diego La Jolla, CA Building High Confidence Metabolite Libraries for Fast Identification in Targeted Profiling Experiments; Gina Tan ; Ralf Tautenhahn ; Andreas Huhmer ; Thermo Fisher Scientific, San Jose, CA The -SToP Approach to Annotation of LC-MS Metabolomics Data; Corey D Broeckling ; Andrea Ganna ; Mark Layer ; Brown Kevin ; Ben Sutton ; Erik Ingelsson 4, 5 ; Graham Peers ; Jessica E Prenni ; Colorado State University Proteomics and Metabolomics Facility, Fort Collins, Co; Broad Institute of MIT and Harvard, Cambridge, MA; Colorado State University, Fort Collins, CO; 4 Uppsala University, Uppsala, Sweden; 5 Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden Utilizing Advanced Multivariate Analysis Features with Automated Database Searching Algorithms to Simplify Metabolomics Study Conduct and Understanding; Christopher Colangelo ; Phillip Seitzer ; Rick Schneider ; Primary Ion, Old Lyme, CT; Proteome Software, Portland, OR; Pfizer, Groton, CT Automatic CCS and MS/MS Library Creation and Application for Large Scale Metabolic Profiling; Jonathan P. Williams ; David Eatough ; Lee A. Gethings ; Christopher. J. Hughes ; Mark Towers ; Leanne Nye ; Steven Lai ; Richard Tyldesley-Worster ; Johannes PC Vissers ; Waters Corporation, Wilmslow, United Kingdom; Waters Corporation, London, United Kingdom; Waters Corporation, Beverly, MA Algorithm for Metabolite Identification Based on MS/MS for Untargeted Metabolomics; Guoan Zhang; New York University, New York, NY A Generalizable Method for False-Discovery Rate Estimation in Mass Spectrometry-Based Lipidomics; Grant Fujimoto ; Jennifer E Kyle ; Kevin Crowell ; Richard D Smith ; Thomas O Metz ; Sam Payne ; Pacific Northwest National Lab, Richland, WA MP 6 MP 6 MP 6 MP 64 MP 65 MP 66 MP 67 MP 68 Assessing Metabolic Pathways Using Chemical Kinetics Theory; Ismael Zamora ; Guillem Plasencia ; Laura Goracci ; Lead Molecular Design, S.L., Sant Cugat del Valles, Barcelona; Lead Molecular Design S.L., Sant Cugat de Valles, Spain; Perugia University, Perugia, Italy A Computational Platform for Analysis of Stable Isotope Assisted Metabolomics Data Acquired on GC-MS; Xiaoli Wei, ; Imhoi Koo, ; Biyun Shi, ; Pawel Lorkiewicz, 4 ; Hamid Suhail 5 ; Ramandeep Rattan 5 ; Shailendra Giri 5 ; Xiang Zhang,, ; Department of Chemistry, University of Louisville, Louisville, KY; ulatory and Center for RegEnvironmental Analytical Metabolomics, University of Louisville, Louisville, KY; Pharmacology & Toxicology, University of Louisville, Louisville, KY; 4 Institute of Molecular Cardiology, University of Louisville, Louisville, KY; 5 Henry Ford Health System, Detroit, MI Analysis of Stable Isotope Assisted Metabolomics Data Acquired by High Resolution Mass Spectrometry; Pawel Lorkiewicz ; Xiaoli Wei ; Joshua Salabei ; Biyun Shi ; Bradford Hill ; Seongho Kim ; Craig James McClain, ; Xiang Zhang ; University of Louisville, Louisville, KY; Wayne State University, Detroit, MI; Robley Rex Louisville VAMC, Louisville, KY metax: an Automatic and Comprehensive Pipeline for Processing Metabolomics Data; Bo Wen ; Zhenyu Guo ; David Broadhurst ; Yanqun Fan ; Chunwei Zeng ; Hui Jiang ; Xun Xu ; Siqi Liu ; BGI-Shenzhen, Shenzhen, China; University of Alberta, Edmonton, Canada Informatics: Multiomics Integration A Multi-omics Visualization Platform (MVP) Plug-in for Galaxy-based Applications; Thomas Mcgowan ; James Johnson ; Pratik Jagtap ; Getiria Onsongo ; Candace Guerrero ; Timothy Griffin, ; University of Minnesota Supercomputing Institute, Minneapolis, MN; University of Minnesota, Minneapolis, MN; Center for Mass Spectrometry and Proteomics, UMN St.Paul, MN From Start to Finish: a Complete Proteogenomic Informatics Environment Implemented in the Galaxy Platform; Getiria Onsongo ; Pratik D Jagtap ; James E Johnson ; Thomas McGowan ; Mohammad Heydarian 4 ; Karen Reddy 5 ; Timothy J Griffin ; University of Minnesota, Minneapolis, MN; University of Minnesota at Twin Cities, Saint Paul, MN; University of Minnesota Supercomputing Institute, Minneapolis, MN; 4 Johns Hopkins University, Baltimore, Maryland; 5 Johns Hopkins University, Baltimore, MD A Multi-Omic Approach to Reveal the Effect of Low- Level Gamma Radiation on Rice Seeds; Gohei Hayashi ; J Shibato ; A Kubo ; T Imanaka ; GK Agrawal 4 ; S Shioda ; M Fukumoto 5 ; G Oros 6 ; Randeep Rakwal 7 ; Sa Deepak 8 ; Gundimeda Seetaram 9 ; Upendra Simha 0 ; Padmanaban Arunkumar 0 ; Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Hoshi University, Tokyo, Japan; NIES, Tsukuba, Japan; 4 RLABB, Kathmandu, Nepal; 5 Tohoku University, Sendai, Japan; 6 Plant Protection Institute, Budapest, Hungary; 7 Tsukuba University, Tsukuba, Japan; 8 Agilent Technologies, Bangalore, Bangalore; 9 Agilent technologies, Bangalore, India; 0 Agilent Technologies (India) Pvt. Ltd., Bangalore, India Global Analysis of Lipidomics, Oxylipin and Metabolomics Data Sets in Paediatric Plasmodium Falciparum Malaria; Izabella Surowiec ; Sandra Gouveia- Figueira ; Tomas Skotare ; Judy Orikiiriza ; Elisabeth Lindquist ; Sven Bergström ; Johan Normark ; Johan Trygg ; Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden; Infectious Diseases Institute, School of Medicine and Health Sciences, Makerere University, Kampala, Uganda; Department of Molecular Biology, Umeå University, Umeå, Sweden 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

72 GENERAL MONDAY INFORMATION POSTERS MP 69 MP 70 MP 7 MP 7 MP 7 MP 74 MP 75 MP 76 MP 77 MP 78 MP 79 MP 80 An NGS-Independent Strategy for Proteome-Wide Identification of Single Amino Acid Polymorphisms by Mass Spectrometry; Wenqing Shui ; Yun Xiong ; Yufeng Guo ; Weidi Xiao ; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, Tianjin; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, CN; Nankai university, Tianjin, China The Fragmentarium: A Universal Query Service Enabling Partial Matching of Unidentified Spectra across the Full Gamut NIST MS Spectral Libraries; Manor Askenazi ; Stephen Stein ; Biomedical Hosting LLC, Arlington, MA; NIST, Gaithersburg, MD Precise Label-Free Quantitative Proteomes in High- Throughput Using microlc-swath-ms; Jakob Vowinckel ; Aleksej Zelezniak, ; Markus Ralser, ; University of Cambridge, Cambridge, UK; The Francis Crick Insitute, London, UK ProteoGenomics: Linking between Ensembl and PRIDE using ProteoAnnotator; Fawaz Ghali ; Simon Perkins ; Tobias Ternent ; Juan Antonio Vizcaino ; Henning Hermjakob ; Andy Yates ; Paul Flicek ; Andy Jones ; University of Liverpool, Liverpool, United Kingdom; EMBL- EBI, Hinxton, UK Crosstalker: A Biological Network Analysis Platform With an Emphasis on Openness; Sean Maxwell, ; Mark R Chance, ; Case Western Reserve University, Cleveland, OH; NeoProteomics, Inc. Cleveland, OH Looking for Black Sheep: Identifying Significant Proteogenomic Outliers; Emily Kawaler ; Kelly V Ruggles ; David Fenyo ; Center for Health Informatics and Bioinformatics, New York University Medical School, New York, NY probamsuitea Bioinformatics Framework for Genome- Based Representation and Analysis of Proteomics Data; Xiaojing Wang ; Robbert J Slebos ; Matthew C. Chambers ; David L. Tabb ; Daniel C. Liebler ; Bing Zhang ; Vanderbilt University, Nashville, TN Systematic Analysis of Phosphosignaling-Affecting Mutations in a Large Clinical Breast Cancer Cohort; Karsten Krug ; Philipp Mertins ; Lauren Tang ; Jana Qiao ; Filip Mundt ; Karl R Clauser ; Michael A Gillette ; Li Ding ; Kelly V Ruggles ; David Fenyo ; Matthew Ellis 4 ; D.R. Mani ; Steven A Carr ; Broad Institute of MIT and Harvard, Cambridge, MA; Washington University School of Medicine, St. Louis, MO; New York University, New York, NY; 4 Baylor College of Medicine, Houston, TX Detection of Colorectal Cancer Related Antibody Peptides Using Proteogenomics; Seong Won Cha ; Vineet Bafna ; UCSD, La Jolla, California; UCSD, La Jolla, CA A Comprehensive Proteogenomic Workflow Reveals Novel Insights into Leukemogenesis; Jarrod Sandow; The Walter & Eliza Hall Institute, Parkville, VIC Taxonomic Characterization of Metaproteomes Using Databases of Translated Metagenomic Sequencing Reads; Damon May ; Emma Timmins-Schiffman ; Molly Mikan ; Rodger Harvey ; Elhanan Borenstein ; Brook Nunn ; William S Noble ; University of Washington, Seattle, WA; Old Dominion University, Norfolk, VA Integrating Global Proteome and Phosphoproteome Expression into the Cancer Cell Line Encyclopedia; David Nusinow ; John Szpyt ; Christopher M Rose ; Mahmoud Ghandi ; Levi A Garraway, ; Steven P Gygi ; Harvard Medical School, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA; Dana Farber Cancer Institute, Boston, MA MP 8 MP 8 MP 8 MP 84 MP 85 MP 86 MP 87 MP 88 MP 89 MP 90 MP 9 MP 9 MP 9 MP 94 Instrumentation: New Concepts 8-0 Microfabrication and Evaluation of the T-Probe: A Novel Device for Online in situ Live Single Cell MS Analysis; Renmeng Liu ; Yanlin Zhu ; Ning Pan ; Zhibo Yang ; University of Oklahoma, Dept. of Chem & Biochem Norman, OK An Alternative to a Direct Insertion Probe using a Traditional GCMS Pyrolyzer Instrument; Ben Peters ; Karen Sam ; Gary Deger ; CDS Analytical, Oxford, PA Development of Automated Screening and Quantitation Method on Novel On-Line SFE-SFC-MS/MS Platform (I) For 4 Restricted Perflurocompounds; Jie Xing ; Jun Xiang Lee ; Peiting Zeng ; Zhaoqi Zhan ; Shimadzu (Asia Pacific) Pte Ltd, 79 Science Park Drive #0-0/08, Singapore Facilitating Disulfide Bond Assignments in a Bottom- Up Proteomics Procedure Combined with Online LC Electrochemistry MS; Linda Switzar ; Arnoud de Ru ; Agnieszka Kraj ; Jean-Pierre Chervet ; Annemieke Aartsma-Rus ; Yuri EM van der Burgt ; Peter A van Veelen ; Leiden University Medical Center (LUMC), Leiden, The Netherlands; Antec, Zoeterwoude, The Netherlands Novel Ion Optics Boosting the Sensitivity of Proton- Transfer-Reaction - Time-of-Flight Mass Spectrometry (PTR-TOFMS); Alfons Jordan ; Christian Lindinger ; Stefan Feil ; Paul Mutschlechner ; Gernot Hanel ; Eugen Hartungen ; Jens Herbig ; Lukas Märk ; Simone Jürschik ; Philipp Sulzer ; IONICON Analytik GmbH., Innsbruck, Austria Digitally-Driven Ion Funnels to Enhance High Mass Ion Collection; Bojana Opacic ; Liang Wang ; Brian H Clowers ; Peter Ta Reilly ; Washington State University, Pullman, WA A Segmented Linear Quadrupole Ion Trap for Enhanced Activation and Storage; Dimitris Papanastasiou ; Emmanuel Raptakis ; Diamantis Kounadis ; Ioannis Orfanopoulos ; Alexander Lekkas ; Andreas Mpozatzidis ; Fasmatech, Athens, Greece Analysis of Species of N in Environmental Samples and H in Inorganic Samples by New Type of Quadrupole Mass-Spectrometer; Adolf Goetz Dr. ; Michael Laessig ; Thimo Post ; Bernd Apelt 4 ; Peter Paplewski 5 ; Inprocess Instruments, Bremen,, Germany; Bremen, Bremen,, Germany; Bremen, Bremen, Germany; 4 Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany; 5 Bruker, Karlsruhe, Germany A Simple Ion Funnel-Based Device for the Thermalization and Transmission of Megadalton Ions; Staci N Anthony ; Benjamin E Draper ; Martin F Jarrold ; Indiana University Dept. Chemistry, Bloomington, IN Ion Confinement in a Fourier Transform Electrostatic Linear Ion Trap via Mirror-Switching: Correction of a Voltage-Induced Frequency Drift; Eric Dziekonski ; Joshua T.K. Johnson ; Santini Robert ; Scott A McLuckey ; Purdue University-Department of Chemistry, West Lafayette, IN Mass Manipulation of Ions in a Cryogenic Linear Ion Trap: Simulations and Experiment; Larry Tesler ; Nicolas C Polfer ; University of Florida, Gainesville, Florida Ion Journey in a Mass Spectrometer: Simulation of the Ion Trajectories from an Atmospheric Pressure source to the mass analyzer; Xiaoyu Zhou ; Zheng Ouyang ; Purdue University, west lafayette, Indiana; Purdue University, West Lafayatte, IN Maximizing Linear Quadrupole Resolution and Sensitivity Using Digital Waveform Manipulation; Zachary Philip Gotlib ; Gregory Forrest Brabeck ; Peter Ta Reilly ; Washington State University, Pullman, WA Mapping the Pseudopotential Well at all Points in PAGE 7 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

73 MONDAY POSTERS MP 95 MP 96 MP 97 MP 98 MP 99 MP 00 MP 0 MP 0 MP 0 MP 04 MP 05 the Stability Diagram; Peter Ta Reilly ; Gregory Forrest Brabeck ; Washington State University, Pullman, WA Lead-Free Ceramic Continuous Dynode Electron Multiplier; Hiroshi Kobayashi ; Motohiro Suyama ; Hamamatsu Photonics K.K., Iwata, Shizuoka; Hamamatsu Photonics K.K., Iwata, Japan Vacuum Ultra-Violet (VUV) Detection as a Complement to Mass Spectrometry (MS) Analysis of Biological Metabolites; Shinji Kenneth Strain ; James Diekmann ; Brooke Barnette ; Mark Emmett, 4, 5, 6 ; Dept of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX; VUV Analytics, Austin, TX; Dept of Biochemistry and Molecular Biology, University of Texas Medica Branch, Galveston, TX; 4 Dept of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX; 5 Dept of Radiation Oncolog, University of Texas Medical Branch, Galveston, TX; 6 UTMB Cancer Center, University of Texas Galveston, USA A Modular Data Station for Radio-Frequency Ionization FT-ICR Mass Spectrometry Built on Robust and Expandable Commercial Architectures for Imaging Applications; Matthew R Brantley ; Solouki Touradj ; Baylor University, Waco, TX Multiplexed Targeted Assays Using Ion Trap Waveform Isolation; Philip M Remes; Thermo Fisher Scientific, San Jose, CA Deconvolution Method for Multiple Harmonics FTMS Spectra; Sergey Smirnov ; Aleksandr Rusinov ; Li Ding ; Shimadzu Research Laboratory (Europe) Ltd., Manchester, United Kingdom; Shimadzu Research Laboratory (Europe) Ltd., Manchester, Manchester Novel Tandem Ionization GCxGC-TOF MS for Characterization of Allergens in Cosmetics; Matthew Edwards ; Joe Blanch ; Laura McGregor ; Nick Bukowski ; Pete Grosshans ; Chris Hall ; Massimo Santoro ; David Wevill ; Markes International, Cardiff, UK; Markes International Inc., Cincinnati, OH Design and Simulation for a Novel Wedge Ion Guide (WIG) to Achieve Ion Compression and Ion Bending; Yupeng Cheng ; Xiaoqiang Zhang ; Wenjian Sun ; Shimadzu Research Laboratory (Shanghai) Co., Ltd., Shanghai, Shanghai; Shimadzu Research Laboratory (Shanghai) Co., Ltd., Shanghai, China Scout-MRM; a Method to Acquire Large Numbers of MRM without Predefined Retention Time; Cox Dave ; Blandine Rougemont ; Romain Carriere ; J.C. YVES LEBLANC 4 ; Lemoine Jerome ; SCIEX, Concord ON, Canada; Institut des Sciences Analytiques - UMR CNRS, Villerbanne (Lyon), France; Institut des Sciences Analytiques - UMR CNRS, Villerabnne (Lyon), France; 4 SCIEX, Concord, ON Intact Proteins 0-9 Making Heavy Peaks With a Pinch of Sugar: A Strategy for Intact Protein MS Quantitation in Any Feed; Jeniffer Quijada, ; Jared R. Auclair, ; Joseph P. Salisbury, ; Jeffrey Agar, ; Barnett Inst., Northeastern University Boston, MA; Northeastern University, Boston, MA An LC-MS based method for monitoring the activation of Mesotrypsin and a Strategy for Quantitation in Cellular Secretions; Derek Wachtel ; Sushmit Maitra ; Keith Goodman ; Dan Warren ; Lyle Burton ; Marco Kessler ; Sanjeev Forsyth ; Maria Ribadeneira ; Ironwood Pharmaceuticals, Cambridge, MA; SCIEX, Concord ON, Canada Separation of Native Proteins and Protein Complexes using Capillary Electrophoresis Coupled with Mass Spectrometry; James Wilkins ; Jonathon Johnston ; Michael J Trnka ; Alma Burlingame ; UCSF, San Francisco, MP 06 MP 07 MP 08 MP 09 MP 0 MP MP MP MP 4 MP 5 CA; UCSF, San Francisco, CA Development of a high quality intact protein standard for LC and MS quality control and application development; Helene Cardasis ; Rosa Viner ; Vikrant Gohil ; Kay Opperman 4 ; John Rogers 4 ; Kelly Flook 5 ; Alexander Cherkassky ; Jim Stephenson ; Egle Capkauske 6 ; Kestutis Bargaila 6 ; Agne Alminaite 6 ; Viktorija Vitkovske 6 ; Juozas Siurkus 6 ; Thermo Scientific, New York, NY; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Cambridge, MA; 4 Thermo Fisher Scientific, Rockford, IL; 5 Thermo Fisher Scientific, Sunnyvale, CA; 6 Thermo Fisher Scientific, Vilnius, Lithuania Novel Strategy for Quality Assessment of Glycosylation on a Biotherapeutic Glycoprotein by Intact Protein Analysis; Unyong Kim, ; Myung Jin Oh, ; Hyun Joong Kim ; Youngsuk Seo, ; Hyun Joo An, ; Asia Glycomics Reference Site, Daejeon, Korea; Graduate School of Analytical Science and Technology, Daejeon, Korea The Use of Methionine Sulfoxide Reductases to Reverse Oxidized Methionine for Mass Spectrometry Applications; Robert Cunningham ; Kratika Singhal ; Ryan T Fellers ; Luca Fornelli ; Henrique Dos Santos Seckler ; Bhavin Patel ; Egle Capkauske 4 ; Juozas Siurkus 4 ; Philip Compton ; John C Rogers ; Neil L Kelleher ; Thermo Fisher Scientific, Rockford, IL; University of Illinois at Chicago, Rockford, IL; Northwestern University, Evanston, IL; 4 Thermo Fisher Scientific, Vilnius, Lithuania Top-Down sequence-specific copper and zinc retention from ECD and ETD of superoxide dismutase for ALS spinal cord; Joe Beckman ; Yury V Vasil ev, ; Nathan I Lopez, ; Valery G Voinov, 4 ; Linus Pauling Institute, Corvallis, OR; e-msion, Inc, Corvallis, Oregon; Oregon State University, Corvallis, OR; 4 Linus Pauling Institute, Oregon State University Corvallis, OR Two-Dimensional Time-Resolved LC-MS Deconvolution for Intact Mass Analysis of Biological Drugs; Peter Haberl ; Joe Shambaugh ; David Bush ; Maurizio Bronzetti ; Cassandra Wigmore ; Arnd Brandenburg ; Genedata GmbH, Munich, Germany; Genedata Inc, Lexington, MA; Genedata AG, Basel, Switzerland Development of LC/MS/MS Bioanalytical Method for Quantitative Determination of Intact Insulin Glargine and Human Insulin in Plasma; ZHAOQI ZHAN ; Zhe Sun ; Jie Xing ; Edwin Zhi Wei Ting ; Shimadzu (Asia Pacific) Pte Ltd, Singapore, Science Park ; Customer Support Centre, Shimadzu (Asia Pacific) Pte Ltd 79 Science Park Drive #0-0/08, Singapore Enabling Mass Spectrometric Analysis of Intact Proteins in Native Conditions on A Hybrid Quadrupole- Orbitrap Mass Spectrometer; Kai Scheffler ; Eugen Damoc ; Aaron Bailey ; Jonathan L Josephs ; Thermo Fisher Scientific, Dreieich, DE; Thermo Fisher Scientific, Bremen, DE; Thermo Fisher Scientific, San Jose, CA Is Online Detection by Native ESI MS Beneficial to Size Exclusion Chromatography?; Cedric Bobst ; Igor A Kaltashov ; University of Massachusetts Amherst, Amherst, MA BAC-PAGE: A Novel Proteomics Workflow Using Dissolvable Polyacrylamide Gel Electrophoresis; Nobuaki Takemori ; Ayako Takemori ; Piriya Wongkongkathep ; Rachel R Ogorzalek Loo ; Joseph A Loo ; Ehime University, Toon, Japan; UCLA, Los Angeles, CA Impact of Phosphorylation on the Ionization Efficiency of Intact Proteins: A Systematic Investigation; Zhijie Wu ; Wenxuan Cai ; Bifan Chen ; Ziqing Lin ; Zachery Gregorich ; Ying Ge ; Department of Chemistry, UW- Madison Madison, WI; University of Wisconsin Madison, Madison, WI 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

74 GENERAL MONDAY INFORMATION POSTERS MP 6 MP 7 MP 8 MP 9 MP 0 MP MP MP MP 4 MP 5 MP 6 MP 7 MP 8 MP 9 Magnetic Resin Microreactor for Affinity-Capture Top- Down Mass Spectrometry; Delafield Daniel ; Zhe Wang ; Woodard Toni ; Si Wu ; University of Oklahoma, Dept. of Chem & Biochem Norman, OK High Resolving Power Isoelectric Focusing for Routine and Comprehensive Proteoform Interrogations; Michael Tran ; John Corbett, ; Daniel A Plymire ; Casey Wing ; Steven M Patrie, ; University of Texas at Dallas, Richardson, TX; University of Texas Southwestern, Dallas, TX On the Reliability and Reproducibility of D Isoelectric Focusing and Reversed-Phase Chromatography with FTMS for Intact Label-free Proteoform Quantitation; John Corbett, ; Michael Tran ; Casey Wing ; Daniel Plymire ; Steven Patrie, ; University of Texas at Dallas, Richardson, TX; University of Texas Southwestern Medical Center, Dallas, TX Data Independent Characterization of Proteins from D CID Fingerprints Generated through Collision Energy Scanning; Boris Kozlov ; Jeff Brown ; John Hoyes ; Waters, Wilmslow, United Kingdom Ion Activation/Dissociation 0-40 Potential Fragmentation of the Hydroxy Carbene; Sabyasachy Mistry; Purdue University, West Lafayette, IN Photodissociation of Triethylphosphonium Charge Tagged Peptides; Nick DeGraan-Weber ; James P Reilly ; Indiana University Dept. Chemistry, Bloomington, IN Structural Determination of Peptides Containing Multiple Acceptors using Action-EET; Lance E Talbert ; Ryan R Julian ; University of California, Riverside, Riverside, CA Implementation and Bench-Marking of Dual-Polarity 9 nm UVPD for Bottom-Up Proteomics on the Thermo Orbitrap Fusion Tribrid Mass Spectrometer; Sylvester Greer ; Jennifer S Brodbelt ; Univ of Texas at Austin, Austin, Texas; University of Texas at Austin, Austin, TX Reaction Dynamics of Small Sulfur-Containing Molecules with a Hydrated Electron in the Gas Phase; Chi-Kit Siu ; Wai-Kit Tang ; City University of Hong kong, Hong Kong; City University of Hong Kong, Hong Kong SAR, Hong Kong Kinetic Energy Release and Fragmentation Pattern of Substituted Anilines after Collision Activation; Sarah Seulen ; Tassilo Muskat ; Jürgen Grotemeyer ; Institute for Physical Chemistry, Christian-Albrechts-University at Kiel, Kiel, Germany Photodissociation Action Spectroscopy of Fluorescent Dye Molecules in the Gas Phase; Elena Mitrofanov ; Tassilo Muskat ; Claus Gernert ; Jurgen Grotemeyer ; Institute for Physical Chemistry, Christian-Albrechts- University at Kiel, Kiel, Germany Difference of Electron Capture and Transfer Dissociation Mass Spectrometry on Zn+-Polyhistidine Complexes in the Absence of Remote Protons; Daiki Asakawa ; Edwin De Pauw; AIST, Tsukuba, Ibaraki Glycan and Peptide Analysis with Iron Oxide Nanoparticle MALDI Matrices; Joseph Mercer Wilson ; Qiaoli Liang ; Jennifer Sherwood ; Thomas Macher ; Yuping Bao ; Carolyn J Cassady ; University of Alabama, Tuscaloosa, AL Characterized Fragmentation of Neutral Carbohydrates Induced by Quartz-Tungsten-Halogen Light Prior to MALDI Mass Spectrometry; Yu-Meng Ou ; Yin-Hung Lai ; Yi-Sheng Wang ; Genomics Research Center, Academia Sinica Taipei, Taiwan MP 0 Optimizing Production of Selected Product Ions for SRM Analysis in a Quadrupole Collision Cell; Bennett Kalafut ; Harald Oser ; Thermo Fisher Scientific, San Jose, California MP Cationized Polymer Fragmentation: Energetic and Mechanistic Effects of End-group Substitution; Jordan M. Rabus ; Benjamin Bythell ; University of Missouri-St. Louis, St. Louis, MO MP The Collision of a Hypervelocity Massive Projectile with Free-Standing Graphene: Investigation of Secondary Ion Emission and Projectile Fragmentation; Sheng Geng ; Stanislav S Verkhoturov ; Michael J Eller ; Emile A Schweikert ; Texas A&M University, College Station, TX MP Comparison of Ion Temperatures in a Linear Trap using the Ambient Ionization Techniques: ESI, DART and APCI; George N. Khairallah ; Morphy Dumlao ; Richard A J O Hair ; William A Donald ; Bio Inst,Uni of Melbourne and Accurate Mass Scientific P/L, Melbourne, VIC; University of New South Wales, Sydney, Australia; University of Melbourne, Victoria, Australia MP 4 Exploring the Combination of Helium Charge Transfer Dissociation (He-CTD) and Hydrogen Deuterium Exchange Tandem Mass Spectrometry (HDX-MS/ MSn); Gregory C. Donohoe ; Li Pengfei ; Glen P. Jackson ; Stephen J Valentine ; West Virginia University, Morgantown, WV MP 5 Dissociation of Gas-Phase, Triply-Charged Lanthanide and Doubly-Charged Actinide Complexes by Multiple- Stage Tandem Mass Spectrometry; Cassandra Hanley ; Michael Van Stipdonk ; Duquesne University, Pittsburgh, PA MP 6 Chemical Derivatization to Enhance 66 nm Ultraviolet Photodissociation for Proteomics; M. Montana Quick ; Rachel Mehaffey ; Lucas D. Akin ; Jennifer S Brodbelt ; University of Texas at Austin, Austin, TX MP 7 Dissociation of Gas-Phase, Doubly-Charged Uranyl- Acetone and Uranyl-Dimethyl Sulfoxide Complexes by Collisional Activation and Infrared Photodissociation; Theodore Corcovilos ; Cassandra Hanley ; Evan Perez ; Benjamin J Bythell ; Michael J. Van Stipdonk ; Duquesne University, Pittsburgh, PA; University of Missouri-St.Louis, St. Louis, MO MP 8 General Rules of Fragmentations Evidencing Lasso Structures in CID and ETD; Kevin Jeanne Dit Fouque ; Helene Lavanant ; Severine Zirah ; Julian D. Hegemann ; Marcel Zimmermann ; Mohamed A. Marahiel ; Sylvie Rebuffat ; Carlos Afonso ; Normandie Univ, CNRS UMR 604 COBRA Mont St Aignan, France; National Museum of Natural History, CNRS-MNHN UMR 745 Paris, FRANCE; Philipps University Marburg, Department of Chemistry Biochemistry LOEWE Marburg, Germany MP 9 A Novel Macrobicyclic Polyether with Carbon Bridgehead Atoms: Complexation with Alkali Metals; Anupriya Anupriya ; David V Dearden ; Brigham Young University, Provo, UT MP 40 Ab InitioPrediction of Collision-Induced Dissociation Mass Spectra; Li Li ; Rodger Mensing ; Benjamin Janesko ; University of Texas at Arlington, Arlington, TX; Texas Christian University, Fort Worth, TX Ion Mobility: Applications (Other/Instrumentation) 4-7 MP 4 Characterization of i-motif DNA Kinetically Trapped Folding Intermediates Using nanoesi-tims-ms and Molecular Dynamics; Alyssa Garabedian ; David Butcher ; Jennifer Lippens ; Jaroslava Miksovska ; Prem Chapagain ; Daniele Fabris ; Mark E Ridgeway ; Melvin Park ; Francisco Fernandez-Lima ; Florida International University, Miami, FL; The RNA Institute, University at Albany Albany, NY; Bruker Daltonic, Billerica, MA PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

75 MONDAY POSTERS MP 4 MP 4 MP 44 MP 45 MP 46 MP 47 MP 48 MP 49 MP 50 MP 5 MP 5 MP 5 MP 54 Analysis of Synthetic Nucleotides using Accurate Mass and Ion Mobility; Cynthia Sanderson ; Sushmit Maitra ; Keith Goodman ; SCIEX, Concord ON, Canada High Resolution Ion Mobility-Mass Spectrometry for Separation of isomers in Natural Products and Complex Mixtures; Michael Groessl ; Sonja Klee ; Stephan Graf ; TOFWERK, Thun, Switzerland Frequency Encoding the Mobility of Isomeric Glycans: Separations Using Drift Tube Ion Mobility and Tandem Mass Spectrometry; Kelsey A Morrison ; Brad K Bendiak ; Brian H Clowers ; Washington State University, Pullman, WA; University of Colorado, Denver - Anschutz Medical Campus, Denver, CO Rapid and High-Throughput Detection and Quantitation of Radiation Biomarkers in Human and Nonhuman Primates by Differential Mobility Spectrometry-Mass Spectrometry; Zhidan Chen ; Stephen L. Coy ; Evan L. Pannkuk ; Evagelia C. Laiakis ; Adam B. Hall ; Albert J Jr Fornace ; Paul Vouros ; Northeastern University, Boston, MA; Georgetown University, Washington, DC Enhancing Carbohydrate Isomer Separation with Ion Mobility Spectrometry-Mass Spectrometry; Xueyun Zheng ; Xing Zhang ; Nathaniel S Schocker ; Roger A Ashmus ; Igor C Almeida ; Keqi Tang ; Catherine E Costello 4 ; Richard D Smith ; Katja Michael ; Erin Baker ; Pacific Northwest National Laboratory, Richland, WA; University of Colorado, Denver, CO; University of Texas, El Paso, TX; 4 Boston University School of Medicine, Boston, MA Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave IM- MS; Kelly M Hines ; Jody C May ; John A McLean ; Libin Xu ; University of Washington, Seattle, WA; Vanderbilt University, Nashville, TN Rapid Differentiation of Bile Acid Isomers Using Sodiated Multimer Complexes with Ion Mobility - Mass Spectrometry; Robin H.J. Kemperman ; Christopher D Chouinard ; Richard A Yost ; University of Florida, Gainesville, FL Machine Learning-Enabled Collisional Cross Section Predictor (CCSP) for Identification of Unknown Lipids; Molly T Soper-Hopper ; Nga Lee Ng ; Nicholas V Hud ; Charles Liotta ; Facundo M Fernandez ; Georgia Institute of Technology, Atlanta Reducing Isobaric Species by Differential Mobility Spectrometry (DMS) for infusion-based lipidomics; Goncalo Vale ; Jeff McDonald ; Paul RS Baker ; UT Southwestern Medical Center, Dallas, TX; Sciex, Framingham, MA Characterization of Exposome Compounds in Human Biofluids Using LC-ESI-Ion Mobility QTOF Mass Spectrometry; Yunjia Lai ; Mine Palazoglu ; Oliver Fiehn ; UC Davis Genome Center, Davis, CA Increasing the Resolving Power of Differential Mobility to Supplement (or Eliminate) LC Separation; J.C. Yves Leblanc ; Chang Liu ; Larry J Campbell ; Brad Schneider ; SCIEX, Concord, ON, ON; SCIEX, Concord ON, Canada Enhanced Ion Mobility Separation of Derivatized Isobaric Steroids by DESI and MALDI TOF Mass Spectrometry; Mark Towers ; MicShazia Khan ; C.Logan C Mackay ; Ruth Andrew ; Emmanuelle Claude ; Waters Corporation, Wilmslow, UK; Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK; SIRCAMS, University of Edinburgh, Edinburgh, UK Rapid separation of Vitamin D epimers in human serum by Liquid Chromatography Ion Mobility Mass Spectrometry; Nicholas Oranzi ; Christopher D Chouinard ; Richard A Yost ; University of Florida, Gainesville, FL MP 55 MP 56 MP 57 MP 58 MP 59 MP 60 MP 6 MP 6 MP 6 MP 64 MP 65 Combining Rapid Isomer Separations and Physicochemical Property Predictions for Drug Molecules with Differential Mobility Spectrometry; CHANG LIU ; Yves J C LeBlanc ; Jefry Shields ; Hui Zhang ; John S Janiszewski ; Christian Ieritano ; Luke Melo ; Evan Shepherson ; Mitch Verbuyst ; Moaraj Hasan ; Dalia Naser ; Scott W Hopkins ; Larry J Campbell ; Tim Hoffman ; SCIEX, Concord, ON; Pfizer, Groton, CT; University of Waterloo, Waterloo, Ontario (ON) Complicated Natural Product Analysis Using Liquid Chromatography (LC) Drift Tube Ion Mobility (DTIM) Mass Spectrometry (MS); Xin Ma ; Tao Bo ; Agilent Technologies, Beijing, China; Agilent Technologies (China) Limited, Beijing, China Structural Database of Secondary Metabolites for Natural Product Discovery: Ion Mobility-Mass Spectrometry Measurements in Nitrogen and Helium Drift Gases; Andrzej Balinski ; Jody C May ; Brian O Bachmann ; Sarah M Stow ; John A McLean ; Vanderbilt University, Nashville, TN Determining Molecular Modifications by ESI Ion Mobility Mass Spectrometry (ESI IM-MS); Alfred L. Yergey ; Paul S Blank ; Stephanie M Cologna ; Peter S Backlund ; Allan Darling ; NIH, Bethesda, MD; University of Illinois, Chicago, IL; Vtesse Inc, Gaithersburg, MD Analysis of Propolis Extracts and Isomeric Flavonoid Mixtures Using Trapped Ion Mobility QTOF-MS; Sven Wolfgang Meyer ; Alexander Harder ; Detlev Suckau ; Peter Sander ; Bruker Daltonic GmbH, Bremen, Bremen; Bruker Daltonic, Bremen, Germany; Bruker Daltonic GmbH, Bremen, Germany Investigation of the Cu(I) and Zn(II) Binding Characteristics of Methanobactin from Methylosinus trichosporium OBb; Jacob Watson McCabe ; Rajpal Vangala ; Laurence Ambrose Angel ; Texas A&M University - Commerce, Commerce, TX Single Oligomer Polyurethane Synthesis: Characterization by Ion Mobility-Mass Spectrometry and Computational Strategies; Tiffany Crescentini, ; Sarah M Stow, ; Robert W. Davis, ; Gary A. Sulikowski,, ; David M Hercules, ; John A McLean, ; Vanderbilt Dept. of Chemistry, Nashville, TN; Vanderbilt University, Nashville, TN; Vanderbilt Institute of Chemical Biology, Nashville, TN Characterization of Conformational Isomers of Bisthienylethenes (BTEs) Using Ion Mobility Mass Spectrometry; Xu Wang ; Ming Wang ; Alejandro Cisneros ; Xiaopeng Li ; Texas State University, San Marcos, TX Enhancing Analytical Characterization Workflows of Complex Synthetic Polymeric and Small Molecule Mixtures through Liquid Chromatography Ion Mobility Mass Spectrometry (LC-IM-MS); John Patrick O Brien ; Jeffrey R Gilbert ; Bruce M Bell ; The Dow Chemical Company, Midland, MI; Dow AgroSciences, Indianapolis, IN Comparison of Ion Mobility Mass Spectrometry Applications on Commercial Drift-Tube and Differential Mobility Based Instruments; Jeffrey Gilbert ; Jesse L Balcer ; John O Brien ; David McCaskill ; Yelena A Adelfinskaya ; Gerrit J Deboer ; Cassie Fhaner ; Krishnamoorthy Kuppannan ; Mary D Evenson ; Lisa Buchholz ; Bruce Bell ; Dow AgroSciences, Indianapolis, IN; Dow Chemical Company, Midland, MI Separation of Positional Isomers of PAHSAs Using LC-MS/MS Coupled with Differential Ion Mobility Mass Spectrometry; Shaokun Pang ; Liling Liu ; Xiaorong Liang ; Amos Baruch ; Leo Wang ; Brian Dean ; Yuzhong Deng ; SCIEX, Redwood City, CA; Genentech Inc, South San Francisco, CA 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 75

76 GENERAL MONDAY INFORMATION POSTERS MP 66 MP 67 MP 68 MP 69 MP 70 MP 7 MP 7 MP 7 Structural Dependent Section of Calibrants for Accurate Measurement of CCS Values Obtained with Ion Mobility Mass Spectrometry; Dongwan Lim ; Arif Ahmed ; Sunghwan Kim ; Kyungpook National University, Daegu, Republic of Korea Enantiomer Separation of Amino Acids through Binuclear Copper Bound Complex by Travelling Wave Ion Mobility Mass Spectrometry; Xiang-Ying Yu ; Zhong- Ping Yao, ; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), Shenzhen Research Institute of The Hong Kong Polytechnic University, Shenzhen, China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China Maintaining Speciation of Reactive Gas-Phase Complexes for the Metals Uranyl, Barium, Cesium and Lanthanum with Sulfoxides using AP-IMS-MS; Austen Davis ; Brian H Clowers ; Washington State University, Pullman, WA Ion Mobility Mass Spectrometry of Polyoxometalate Anion Assemblies; Helene Lavanant ; Sebastien Hupin ; Michael Groessl ; Madeleine Piot ; Guillaume Izzet ; Carlos Afonso ; Normandie Univ, CNRS UMR 604 COBRA Mont St Aignan, France; TOFWERK, Thun, Switzerland; Sorbonnes Univ, CNRS UMR 8 IPMC Paris, France Ion Mobility Quadrupole Time-of-Flight Mass Spectrometer Modified for Electron Capture Dissociation of Glycans, Glycoconjugates, Peptides, and Proteins; Rebecca S. Glaskin ; Kenneth Newton ; Ruwan T. Kurulugama ; George C. Stafford ; Valery G. Voinov ; Joseph S. Beckman ; Douglas F. Barofsky ; Catherine E. Costello ; Boston University School of Medicine, Boston, MA; Agilent Technologies, Santa Clara, CA; Linus Pauling Institute, Oregon State University Corvallis, OR On-line Parallel Accumulation Serial Fragmentation (PASEF) for Shotgun Proteomics on a Modified UHR- QTOF Platform; Scarlet Beck ; Florian Meier ; Jürgen Cox ; Markus Lubeck ; Stephanie Kaspar-Schoenefeld ; Nicole Drechsler ; Niels Goedecke ; Melvin Park ; Oliver Raether ; Matthias Mann ; Max-Planck-Institute of Biochemistry, Martinsried (near Munich), Germany; Bruker Daltonic GmbH, Bremen, Germany; Bruker Daltonic, Billerica, MA Bio-Molecule Characterization Using a Novel Ion Mobility Orbitrap Mass Spectrometer; Sung Hwan Yoon ; Thomas Schneider ; Tao Liang ; Yue Huang ; Robert K Ernst ; Mikhail E Belov ; David R Goodlett, 4 ; University of Maryland, Baltimore, MD; Deurion LLC, Seattle, WA; Spectroglyph LLC, Kennewick, WA; 4 University of Maryland Baltimore, Baltimore Improvement of Selectivity and Detection Capabilities in Non-Targeted Metabolomics Using Liquid Chromatography with Drift Tube Ion Mobility Mass Spectrometry; Tim Causon, ; Teresa Mairinger, ; Stephan Hann, ; University of Natural Resources and Life Sciences (BOKU Vienna), Vienna, AT; Austrian Centre of Industrial Biotechnology (acib), Vienna, AT Ion Molecule, Ion/Ion, Ion/Electron Interactions MP 74 Radical Cations of Nucleobases: A Gas-Phase Reactivity and Structural Elucidation Study; Michael Lesslie ; Lawler T John ; Courtney Kanak ; Ryzhov Victor ; Northern Illinois University, DeKalb, IL MP 75 Gas-Phase Reactions of the Deprotonated Nucleobases with H, N, and O Atoms; Charles Nichols ; Zhe-Chen Wang ; Carl W Lineberger ; Veronica M Bierbaum ; University of Colorado, Boulder, CO MP 76 MP 77 MP 78 MP 79 MP 80 MP 8 MP 8 MP 8 MP 84 MP 85 MP 86 MP 87 Charge Transfer Dissociation (CTD) of Phosphocholines: Gas-Phase Ion/Ion Reactions between Helium Cations and Phospholipid Cations; Pengfei Li ; Glen P Jackson ; West Virginia University, Morgantown, WV DNA/Peptide Complex Ion Dissociations: Survivor Non-Covalent Sites in Three-Body Product Ions Independent on Charge Polarity; Bessem Brahim ; Sandra Alves ; Jean-claude Tabet, ; University Paris VI (UPMC) case 45 UMR 8 CNRS, Paris Cedex O5, France; CEA, ibitec-s SPI LEMM Gif Sur Yvette, France Modulating the Interaction of Non-Covalent Dimers with Conformationally Restricted Peptides in the Gas Phase; Huong (Ivy) Thi Huynh Nguyen ; Frantisek Turecek ; University of Washington, Department of Chemistry Seattle, WA; University of Washington, Seattle, WA Ion/Ion Proton-Transfer Reaction for Improved Negative-Ion Electron Capture Dissociation Efficiency in the Structural Characterization of Nucleic Acids and Proteins; Kevin M Ileka ; Jeremy J Wolff ; Kristina Hakansson ; University of Michigan, Ann Arbor, MI; Bruker Daltonic, Billerica, MA Origin of the Regioselective [NH+CO] Concomitant Losses from Aspartate Predicted by Calculations and Evidenced by C and D Labeling; Pierre Saint Hilaire ; Anna Warnet ; Ulli Martin Hohenester ; Yves Gimbert ; Marie-Françoise Olivier ; Francois Fenaille ; Benoit Colsch ; Christophe Junot ; Jean-Claude Tabet, 4 ; CEA, ibitec-s, SPI, LEMM,, Gif Sur Yvette Cedex, France; Université Grenoble Alpes et CNRS UMR 505, Grenoble, France; University Paris VI (UPMC) case 45 UMR 70 CNRS, Paris Cedex O5, Ile de France; 4 CEA, ibitec-s SPI LEMM Gif-sur-Yvette, France Cation Influence on the Competitive Ion-Dipole and Ion-Ion Interaction: Distinction of Hexose Phosphate Structural Isomers Using Basic Amino Acids; Ekaterina Dariy ; Sandra Alves ; Alain Perret ; Jean-claude Tabet ; CEA-Genoscope/UMR800, Evry, Île-de-France; UPMC- IPCM/CSOB/UMR8, Paris Cedex 05, France; CEA- Genoscope/UMR800, Evry, France Distinguishing Hexose Isomers by Lithiated Ion Adduction to Water; Matthew Campbell ; Chen Dazhe ; Gary L. Glish ; UNC, Chapel HIll, NC; UNC-Chapel Hill, Chapel Hill, NC Ion-Molecule Reactions of Fe+ and FeO+ with Ozone: Temperature Dependent Kinetics and Reaction Pathways; Tri Le ; Gregory Miller ; Joshua Melko ; University of North Florida, Jacksonville, FL Bimolecular Reactions between Water and Metal Dioxide Cations, MO+: Energetics and Mechanisms of Hydration, Hydrolysis and oxo-exchange; Phuong D. Dau ; John Gibson ; David Dixon ; Kirk A. Peterson ; Monica Vasiliu ; Richard E Wilson 4 ; Lawrence Berkeley National Laboratory, Berkeley, California; University of Alabama, Tuscaloosa, AL; Washington State University, Pullman, WA; 4 Argonne National Laboratory, Argonne, IL Dual-Electrospray Synthesis and Reactions; Shaan Rashid ; Paul Michael Mayer ; University of Ottawa, Ottawa, Canada; University of Ottawa, Ottawa, ON Efficient and Direct Amide Bond Formation Using a Novel Alcohol/Amine Cross-Coupling Reaction Mediated by Electrospray-Based Photo-catalysis; Savithra Jayaraj ; Qiongqiong Wan ; Abraham Badu- Tawiah ; The Ohio State University, Columbus, OH Phenylnitrenium Ions: Gas-phase Synthesis, Properties in Selective Alkane Activation, Gas-phase acidity, Hydride Affinity, Electron Affinity, and Electronic states; Lei Yue ; Pan Yuanjiang ; Ding Chuanfan ; Zhejiang University, Hangzhou, China; Fudan University, Shanghai, China PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

77 MONDAY POSTERS MP 88 MP 89 MP 90 MP 9 MP 9 MP 9 MP 94 MP 95 MP 96 MP 97 MP 98 MP 99 MP 400 Gas-phase Generation of Protonated COby Collision- Induced Elimination of Benzene from Protonated Benzoic Acid; Sihang Xu ; Athula Attygalle ; Stevens Institute of Technology, Hoboken, NJ Reactions of Substituted Benzene Anions with N and O Atoms: Chemistry in Titan s Upper Atmosphere and the Interstellar Medium; Zhechen Wang ; Veronica M. Bierbaum ; University of Colorado, Boulder, CO Selective Cleavage at Sulfur-Containing Residues via Gas-Phase Platination of Protonated Peptides upon Ion/Ion Reactions with Platinum Trichloride Anion; David Foreman ; Alice L Pilo ; Scott A McLuckey ; Purdue University-Department of Chemistry, West Lafayette, IN Substituent Effects on the Reactivity of the,6-didehydropyridinium Cation, an Unusual meta- Benzyne; Xin Ma ; Joann P. Max ; Duanda Wang ; John J. Nash ; Hilkka I. Kenttämaa ; Department of Chemistry, Purdue University, West Lafayatte, IN Differentiation of Deprotonated Dihydroxybenzene Regioisomers via Ion-Molecule Reactions with Thionyl Chloride; Hanyu Zhu ; Hilkka I Kenttämaa ; Purdue University, West Lafayette, IN Reactions of Fe+ with Ozone: Mapping Reaction Pathways; Gregory Miller ; Tri Le ; Joshua Melko ; University of North Florida, Jacksonville, FL Attempted Generation of the,4-didehydro-5- oxyquinolinium Cation Leads to an Oxygen Peribridged Quinolinium Monoradical; Raghavendhar R Kotha ; John J Nash ; Hilkka I Kenttamaa ; Department of Chemistry, Purdue University, West Lafayette, IN Comparison of the OH-(HO)n + CHI, n = 0-, Rate Constants. Experiment and Simulation; Jing Xie ; Xinyou Ma ; Michael J Scott ; Olivia Harris ; William L Hase ; Peter M Hierl ; Albert A Viggiano 4 ; Department of Chemistry, University of Minnesota, Minneapolis, MN; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX; Department of Chemistry, University of Kansas, Lawrence, KS; 4 Air Force Research Laboratory, Space Vehicles Directorate, Kirtland AFB, NM Gas-Phase Reactivity of Isomeric σ,σ- Biradicals: A Comparison of,4-,,-, and,4-didehydroisoquinolinium Cations; Lucas Szalwinski ; Nelson R Vinueza ; John Nash ; Hilkka Kenttämaa ; Purdue University-Department of Chemistry, West Lafayette, IN Racemization and Isomerization Reactions Induced by High-Velocity Molecular Impacts in the Gas Phase; Sandra Osburn ; Daniel Austin ; Brigham Young University, Provo, UT Calculation of Average-Dipole-Orientation Rate Constants for Proton Transfer Reactions between HO+ and Organic Compounds Using Molecular Mass and Elemental Composition; Kanako Sekimoto, ; Shao- Meng Li ; Bin Yuan, 4 ; Abigail Koss, 4 ; Matthew Coggon, 4 ; Carsten Warneke, 4 ; Joost De Gouw, 4 ; NOAA Earth System Research Laboratory, Boulder, CO; Yokohama City Univ., Yokohama, Japan; Environment Canada, Tronto, Canada; 4 Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO Ion Spectroscopy 99-4 Action-Excitation Energy Transfer Illuminates the Impact of Amino Acid Epimerization and Isomerization on Peptide Structure; Dylan Riggs; University of California - Riverside, Riverside, CA Microsolvation by 8-Crown-6 as a Method for Preserving Native-Like Protein Structure; James Bonner ; Nathan Hendricks ; Ryan R Julian ; UC Riverside, Riverside, CA - California MP 40 Thermochemical Differences in Isomeric Oligopeptides: Structural Insights Using IRMPD Spectros; Patrickhenry Batoon ; Jianhua Ren ; Jos Oomens ; Giel Berden ; University of the Pacific, Stockton, CA; University of the Pacific, Stockton, CA; FELIX Laboratory - IMM - Radboud University, Nijmegen, The Netherlands MP 40 Deep Molecular Structure Probing in MSn by IR Ion Spectroscopy: Deamidation Reaction Networks of Gln and Asn-Containing Dipeptides; Jos Oomens, ; Lisanne JM Kempkes ; Jonathan Martens ; Josipa Grzetic ; Giel Berden ; Radboud University, Nijmegen, Netherlands; University of Amsterdam, Amsterdam, The Netherlands MP 40 Infraredspectroscopy of Protonated and Radical Cationic Triphenylamine; Giel Berden ; Md. Musleh Uddin Munshi ; Jonathan Martens ; Jos Oomens ; FELIX Laboratory - IMM - Radboud University, Nijmegen, The Netherlands MP 404 The Remarkable Ionic Coordinating Ability of Allcis,,,4,5,6 Cyclohexane in the Gas Phase; Terry Mcmahon ; Blake Ziegler ; Michael Lecours ; Rick Marta ; Eric Filliion ; Scott W Hopkins ; David O Hagan 4 ; Keddie Neil 4 ; University of Waterloo, Waterloo, ON; University of Waterloo, Waterloo ON, Canada; University of Waterloo, Waterloo, Ontario (ON); 4 University of St. Andrews, St. Andrews, UK MP 405 Laser Spectroscopic Investigation on Dichlorofluorobenzenes by Means of Resonance Enhanced Multiphoton Ionization and Mass Analyzed Threshold Ionization; Sascha Krüger ; Jürgen Grotemeyer ; Institute for Physical Chemistry; Christian- Albrechts-University at Kiel, Kiel, Germany MP 406 New Insights into the Combustion Chemistry of Butane Isomers in Premixed Low-Pressure Hydrogen Flames by Imaging Photoelectron Photoion Coincidence Spectroscopy; Thomas Bierkandt ; Yasin Karakaya ; Dominik Krüger ; Patrick Hemberger ; Patrick Oßwald ; Markus Köhler ; Tina Kasper ; University of Duisburg- Essen, Duisburg, Germany; Institute of Combustion Technology, German Aerospace Center, Stuttgart, Germany; VUV Spectroscopy Group, Swiss Light Source, Paul Scherrer Institute, Villigen, Switzerland MP 407 Förster Resonance Energy Transfer as a Distance Probe for Gas-phase Ubiquitin Ions; Jocky Chun Kui Kung ; Martin F Czar ; Benjamin Schuler ; Rebecca A Jockusch ; University of Toronto, Toronto ON, Canada; University of Zurich, Zurich, Switzerland MP 408 Alkali Cation Chelation in Cold β-o-4 Tetralignol Complexes; Andrew F DeBlase ; Eric T Dziekonski ; John R Hopkins ; Nicole L Burke ; Huaming Sheng ; Hilkka I Kenttamaa ; Scott A McLuckey ; Timothy S Zwier ; Purdue University-Department of Chemistry, West Lafayette, IN MP 409 Development and Performance of a Mass Selective Linear Ion Trap for Infrared Predissociation Spectroscopy of Metabolites; Adam Cismesia ; Nicolas C Polfer ; University of Florida, Gainesville, Florida MP 40 Photodissociation Dynamics in Infrared Multiple Photon Dissociation Monitored by Time-of-Flight Mass Spectrometry; Matthew Bell ; Nicolas C Polfer ; University of Florida, Gainesville, FL MP 4 Gas Phase Fluorescence Spectroscopy for the Study of Catalytic Nitrogen-Containing Heterocycles; Alessandra Ferzoco ; Vaishnavi Rajagopal ; Rowland Institute at Harvard, Cambridge, MA LC-MS: Chromatography and Software (Part ) MP 4 Demonstration of Automated On-The-Fly Retention Time Updating and SRM Method Visualization for Targeted Peptide Quantitation; Susan Abbatiello ; Qingyu Song ; Mary Blackburn ; Jacek W Sikora ; Paul 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 77

78 GENERAL MONDAY INFORMATION POSTERS Martin Thomas ; Neil Kelleher ; Yupeng Zheng ; Vane Dhevi Sanghvi ; Thermo Fisher Scientific, Cambridge, MA; Thermo Fisher Scientific, San Jose, CA; Kelleher Research Group, Evanston, IL MP 4 An Interactive Skyline Tool for Flagging Incorrectly Chosen Peptides Peaks Across Data-Independent Acquisition Experiments: AT-Peptide Peak Picking (AT- P); Andy Lin ; Jarrett D Egertson ; Brooke Nuun ; Michael J MacCoss ; University of Washington, Seattle, WA MP 44 Column Performance:Comparison of Superficially Porous Particle (SPP) to Fully Porous Particles (FPP) ; Rob Freeman ; Sharon Lupo ; Shun-Hsin Liang ; Frances Carroll ; Ty Kahler ; Susan Steinike ; Restek Corporation, Bellefonte, PA MP 45 High Resolution LC/MS analysis of Therapeutic Oligonucleotides on a New Porous Polymer-Based Reversed Phase Column; Shanhua Lin ; Julia Baek ; Jim Thayer ; Hongxia Wang ; Jonathan L Josephs ; Xiaodong Liu ; Thermo Fisher Scientific, Sunnyvale, CA; Thermo Fisher Scientific, San Jose, CA MP 46 Slightly Bigger is Better: Nano-LCMS with 00um ID columns; Brett Larsen ; Joshua Sandor ; Meghan McFadden ; Anne-Claude Gingras, ; LTRI, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada MP 47 Improving Sensitivity in LC/MS with Multi-Dimensional Chromatography; Thomas E. Wheat ; Amanda B. Dlugasch ; Patricia R. McConville ; Waters Corporation, Hopedale, MA; Waters, Milford, MA MP 48 Maximizing Flexibility: A Gas and Temperature Enabled Chip-Based Solution for Nanoflow and Microflow LC- MS; Helena Svobodova ; Aaron Dewberry ; Amanda Berg ; Gary A Valaskovic ; New Objective, Woburn, MA; New Objective, Inc., Woburn, MA MP 49 Achieving High Proteome Coverage by Miniaturization of HPLC Columns; Annie Moradian ; Roxana Eggleston- Rangel ; Michael Sweredoski ; Sonja Hess ; California Institute of Technology, Pasadena, CA MP 40 Sphingolipid Profiling Using Robust and Sensitive LC- MS-MS Method; Shachi Saluja ; DIpankar Malakar ; Manoj Pillai ; Avinash Bajaj ; Ujjaini Dasgupta ; Regional Centre for Biotechnology, Faridabad, India; Sciex, Gurgaon, India; Amity University, Gurgaon, India MP 4 Evaluation of Critical Column Parameters for Use in Supercritical Fluid Chromatography by SFC-MS; Alison Wicker ; Doug D. Carlton Jr. ; Ty Kahler ; Kevin A Schug ; University of Texas at Arlington, Arlington, TX; Restek Corporation, Bellefonte, PA MP 4 Advancing Separation Sciences under Alkali Conditions Using a Novel C8 Column for LC-MS; Itaru Yazawa ; Yasuo Yamamori ; Hiroshi Tachikawa ; Imtakt Corporation, Kyoto, Japan; Imtakt Corporation, Kyoto, Japan MP 4 Analysis of Antioxidants in Yam (Dioscorea alata L. var. Purpurea (Roxb.) M. Pouch.) by HILIC- UV-ECD-MS; Chih-Hsien Wang ; Gao-Fong Chang ; Wenlung Chen ; Tsai-Fei Yu ; Ya-Chi Feng ; Kuo-Lung Ku ; Department of Applied Chemistry,National Chiayi University, Chiayi City, Taiwan; National Chiayi University, Chiayi City, Chiayi MP 44 Displacement Chromatography Applied for Two- Dimensional Liquid Chromatography Coupled to Tandem Mass Spectrometry for Analysis of Complex Biomolecule Mixtures; Hartmut Schlüter ; Marcel Kwiatkowski ; UKE - Mass Spec Proteomics, Hamburg, Hamburg; UKE - Mass Spec Proteomics, Hamburg, Germany MP 45 Combined New Approaches for Improved Quantitative and Qualitative LC-MS; Stephan Altmaier ; Hans Griesinger ; Michael Schulz ; Merck, Darmstadt, Germany MP 46 MP 47 MP 48 MP 49 MP 40 MP 4 MP 4 MP 4 MP 44 MP 45 MP 46 MP 47 Rapid Separation and Determination Of 5-Hydroxy Vitamin D / D in Serum By UHPLC-MS/MS Using A Novel C8-PFP Stationary Phase ; Geoffrey Faden ; Alan P McKeown ; MACMOD Analytical Inc., 0 Commons Court PO Box 587 Chadds Ford, PA 97; Advanced Chromatography Technologies Ltd, Aberdeen, - Separation and Low Level Determination Of Catecholamines: Epinephrine, Norepinephrine and Dopamine from Plasma By UHPLC-MS/MS Using A Novel C8-PFP Column; Edward Faden ; Alan P McKeown ; MACMOD Analytical Inc., 0 Commons Court PO Box 587 Chadds Ford, PA 97; Advanced Chromatography Technologies Ltd, Aberdeen, - LC/MS as a Monitoring Technique for (semi) Preparative Electrochemical Metabolite Synthesis; Lisa Frensemeier ; Uwe Karst ; University of Münster, Münster, DE Increased MS Protein Identification Rates Using 75 cm Long nano LC C8 Separation Columns: Pushing the Limits of Bottom-Up Proteomics; Daniel Lopez-Ferrer ; Michael Blank ; Stephan Meding ; Aran Paulus ; Romain Huguet ; Remco Swart ; Andreas FR Huhmer ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Germering, Germany Influencing the Selectivity of Small Proteins and Peptides on the Raptor ARC-8; Susan Steinike ; Shun-Hsin Liang ; Sharon Lupo ; Frances Carroll ; Ty Kahler ; Restek Corporation, Bellefonte, PA Extraction and Ionization Efficiency in On-line Supercritical Fluid Extraction and Chromatography Mass Spectrometry for Protease Inhibitors and Steroids in Blood; Laura Akbal ; Michel Raetz ; Kyoko Watanabe ; Yasuhiro Funada ; Gérard Hopfgartner ; University of Geneva, Geneva, Switzerland; Shimadzu, Kyoto, Japan Maximizing Throughput of Shotgun Proteomics by Increasing the Internal Diameter of Nano-Capillary Columns; Yuan-wei Nei ; Danielle B Gutierrez ; William J Burns ; Ashley T Jordan ; Jeremy L Norris ; Richard M Caprioli ; Vanderbilt University MSRC, Nashville, TN; Vanderbilt University Medical Center, Nashville, TN Fast Chromatography For Quantitative Proteomics Workflows; Alina Astefanei ; Garry Corthals ; Petra Jansen ; Michelle Camenzuli ; Andrea Gargano ; University of Amsterdam, Amsterdam, The Netherlands; University of Amsterdam, Amsterdam, ZH Improved Sensitivity for Characterization of Sulfonamides and Trimethoprim in Honey Using QuEChERS Extracts with LC-MS/MS; Hernando Escobar ; Jeffrey H Dahl ; Eddie Medina ; Christopher T Gilles ; Shimadzu Scientific Instruments, Inc., Columbia, MD Quantitative Analysis of Oligonucleotides Using Liquid Chromatography Coupled with High Resolution/ Accurate Mass (HR/AM) Mass Spectrometry; Nidhi Jaiswal ; David M Good ; Marc Browning ; Benjamin Johnson ; Emily Measom ; Cassidy Hatch ; Min Meng ; Scott A Reuschel ; Troy Voelker ; Covance, Salt Lake City, UT; Covance, Madison, WI Complementary ERLIC and RPLC Online Separations Significantly Expand Sequence Coverage in MS-Based Proteomic and Proteogenomic Studies; Candace Guerrero ; Pratik D Jagtap ; James Johnson ; Thomas F McGowan ; Tim Griffin ; University of Minnesota, Minneapolis, MN; University of Minnesota Supercomputing Institute, Minneapolis, MN; University of Minnesota at Twin Cities, Saint Paul, MN A Direct Comparison between Ultrafiltration and Online Size Exclusion Affinity Selection Mass Spectrometry Methods; Christopher Reutter ; Manuel Molina-Martin ; PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

79 MONDAY POSTERS MP 48 MP 49 MP 440 MP 44 MP 44 MP 44 MP 444 MP 445 MP 446 Elizabeth Wright ; Jibo Wang ; Ryan Bernhardt ; Kevin McLeaster ; Eduardo Harguindey ; Miriam del Prado ; Alfonso Espada ; Juan Espinosa ; Michael J Chalmers ; Keith Burton ; Eli Lilly and Company, Indianapolis, IN; Eli Lilly and Company, Alcobendas, Spain An Online D RP-RP LC/MRM-MS Method Provides Higher Sample Throughput for the Analysis of the Human Plasma Proteome; Richard R Vincent ; Andrew J Percy ; Dominik Domanski,,, ; Christoph H. Borchers 4 ; Segal Cancer Proteomics Center, Lady Davis Institute, McGill University, Montreal, QC, Canada; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, CANADA; University of Victoria - Genome BC Proteomics Centre, Victoria, BC; 4 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada NanoLC-MS of Intact Histones by 0.5 µm Nonporous Silica Particles for Top-Down Proteomics; Ximo Zhang ; Michael E Hoover ; Luca Fornelli ; Philip Compton ; Michael A Freitas ; Neil L Kelleher ; Mary Wirth ; Purdue University, West Lafayette, IN; The Ohio State University, Columbus, Ohio; Northwestern University, Evanston, IL Autopiquer Introducing a New Approach to High Confidence Peak Detection; David Kilgour ; Sam Hughes ; David J Clarke ; Quoc Bao Tran 4 ; Clare Coveney ; David J Boocock ; Logan C Mackay ; Young Ah Goo 4 ; David R Goodlett 4 ; Nottingham Trent University, Nottingham; University of Edinburgh, Edinburgh, UK; University of Edinburgh, Edinburgh, United Kingdom; 4 University of Maryland School of Pharmacy, Baltimore, MD Lipids: General Selective Extraction of Phospholipids from Biological Sample with Metal Oxide Chromatography for Mass Spectrometry-Based Analysis; Shota Miyazaki ; Yuko Yui ; Shigenori Ota ; Kosuke Osaka ; Mamoru Kyogashima ; Atsushi Sato ; GL Sciences Inc., Saitama, Japan; GL Sciences Inc., Tokyo, Japan; Nihon Pharmaceutical University, Saitama, Japan Evaluation of Docosahexaenoic Acid Derived Lipid Mediators after Traumatic Brain Injury by a Global LC-MS/MS Method; Tamil Selvan Anthonymuthu ; Lewis Jesse ; Andrew A Amoscato ; Patrick M Kochanek ; Kagan E Valerian ; Hulya Bayir ; University of Pittsburgh, Pittsburgh, PA Lipidomic Analyses of CEACAM Knockout Mouse Liver and Adipose Tissue; Gabriel Gugiu ; Deirdre La Placa ; Zhifang Zhang ; John E. Shively ; City of Hope, Duarte, CA Multiclass Lipid Profiling Using Liquid Chromatography High Resolution Mass Spectrometry with Dielectric Barrier Discharge Ionization; Felipe J Lara-Ortega ; José Robles-Molina ; Bienvenida Gilbert-López ; Juan F Garcia-Reyes ; Antonio Molina-Díaz ; Alexander Schütz 4 ; Sebastian Brandt 4 ; Joachim Franzke 4 ; University of Jaen, Jaen, Es; Csic-Cial, Madrid, Es; University of Jaen, Jaen, Andalucia; 4 Leibniz-Institut für Analytische Wissenschaften, Dortmund, Germany Comparison of Different Stationary Phases for Gangliosides Separation; Ashta Lakshmi Prasad Gobburi ; Renliang Zhang ; Denise Inman ; Anderson J David 4 ; Cleveland State University, Department of Chemistry, Cleveland, OHIO; Cleveland Clinic Lerner Research Institute, Cleveland, OH; Northeast Ohio Medical University, Rootstown, Ohio; 4 Cleveland State University, Department of Chemistr Cleveland, OH High Throughput Solid Phase Microextraction: A New Alternative for Lipid Analysis and Cellular Lipidomics; Afsoon Pajand Birjandi ; Vincent Bessonneau ; Pawliszyn Janusz ; University of Waterloo, Waterloo ON, Canada MP 447 MP 448 MP 449 MP 450 MP 45 MP 45 MP 45 MP 454 MP 455 MP 456 Characterization of Triglycerides and Lipogenesis of Serum Lipids from Dietary or Hepatic Origin: A LC- MS/MS and GC/MS Stable-Isotope Tracer Approach; Sergiu P Palii ; Grace M Jones ; Russell Caccavello ; Alejandro Gugliucci ; Jean-Marc Schwarz, ; Department of Research, College of Osteopathic Medicine, Touro University California, Vallejo, CA 9459; Department of Basic Sciences, College of Osteopathic Medicine, Touro University California, Vallejo, CA 9459; Department of Medicine, University of California San Francisco, San Francisco, CA Steroid Profiling Method for Rat Serum and Plasma by Gas Chromatography/Tandem Mass Spectrometry with Large Volume Injection; Udi Jumhawan ; Toshiyuki Yamashita ; Motonao Nakao ; Kuniyo Sugitate ; Takeshi Serino ; Ryoichi Sasano 4 ; Yoshihiro Izumi ; Takeshi Bamba 5 ; Kyushu University, Fukuoka, Japan; Osaka University, Suita, Japan; Agilent Technologies Co. Ltd, Hachioji, Japan; 4 AiSTI SCIENCE CO.,Ltd., Wakayama, Japan; 5 Kyushu University, Fukuoka, Fukuoka Unsaturated Cholesteryl Ester Analysis from Human Plasma via Online Photochemical Reaction and nanoesi-ms/ms; Jia Ren ; Elissia Franklin ; Yu Xia ; Purdue University, West Lafayette, IN Discovery of Endocannabinoids by Untargeted All-Ions Fragmentation High Resolution LC-MS/MS Screen; Mesut Bilgin, ; Petra Born ; Fezza Filomena, 4 ; Michael Heimes 5 ; Nicolina Mastrangelo 6 ; Nicolai Wagner ; Carsten Schultz 5 ; Mauro Maccarrone 6, 7 ; Suzanne Eaton ; Andre Nadler ; Matthias Wilm 8 ; Andrej Shevchenko ; Danish Cancer Society Research Center, Copenhagen, DK; Max Planck Institute for Cell Biology and Genetics, Dresden, DE; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, IT; 4 European Center for Brain Research/Fondazione Santa Lucia, Rome, IT; 5 European Molecular Biology Laboratory (EMBL), Heidelberg, DE; 6 Department of Medicine, Campus Bio- Medico University of Rome, Rome, IT; 7 European Center for Brain Research/Fondazione Santa Lucia, via del Fosso di Fiorano 65, Rome, IT; 8 Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, IE Role of Ammonium Salts in the Ionization and Fragmentation of Phosphatidylcholines Found in Krill Oil; Michael Rush ; Richard van Breemen ; University of Illinois College of Pharmacy, Chicago, IL Determination of β-glucocerebrosidase (GBA) Activity through Global and Targeted Lipid Profiling; Yi Zeng ; Sangwon Min ; Baris Bingol ; Wendy Sandoval ; Genentech Inc, South San Francisco, CA Separation of Metalated Lipid IsomersUsing Linear and Nonlinear Ion Mobility Spectrometry; Andrew Bowman ; Julia Kaszycki ; Rinat Abzalimov ; Gordon A Anderson 4 ; Alexandre A Shvartsburg ; Wichita State University, Wichita, KS - Kansas; Wichita State University, Wichita, KS; City University of New York, New York City, NY; 4 GAA Custom Engineering, LLC Benton, WA Analysis of Lipids from Biological Samples by Laser Desorption Ionization from Silicon Nanopost Arrays; Andrew Korte ; Akos Vertes ; George Washington University, Washington, DC Polar Lipids from Insect and Tick Cuticle. Analysis and Discovery of their Roles in Semiochemical Signaling; Robert Renthal; University of Texas at San Antonio, San Antonio, TX Natural Variation of Blood Plasma Lipids in Healthy Asian Individuals; Husna Begum, ; Federico Torta ; Pradeep Narayanaswamy ; Piyushkumar Mundra ; Yik- Ying Teo 4 ; Peter Little ; Peter Meikle ; Markus Wenk, ; Life Sciences Institute, National University of Singapore, 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 79

80 GENERAL MONDAY INFORMATION POSTERS MP 457 MP 458 MP 459 MP 460 MP 46 MP 46 MP 46 MP 464 MP 465 Singapore, Singapore; Baker IDI Heart and Diabetes Institute, Melbourne VIC, Australia; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; 4 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore Metabolomics: General Validating the Roles of FraD and FraB in the Metabolism of F-Asn by Salmonella; Jikang Wu ; Anindita Sengupta ; Anice Sabag-Daigle ; Pradip Biswas ; Brian Ahmer ; Venkat Gopalan ; Edward Behrman ; Vicki Wysocki ; Ohio State University, Columbus, OH Exploiting the Sensitivity of Structural Mass Spectrometry as a Next Generation Platform for Metabolomics; Olga Gorlova ; Conrad Wolke ; Sean Colvin ; Scott Miller ; Mark Johnson ; Yale University, New Haven, CT Globally Optimized Targeted Mass Spectrometry (GOT-MS): Reliable Metabolomics Analysis with Broad Coverage; Haiwei Gu ; Ping Zhang ; Jiangjiang Zhu ; Daniel Raftery, ; University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA Targeted Metabolomics to Characterize Lipopolysaccharide Biosynthetic Intermediates in Gram-Negative Bacteria in Response to Chemical and Genetic Perturbations; William Sawyer ; Jade Bojkovic ; Charles R. Dean ; Brian Y. Feng ; Daryl L. Richie ; David A. Six ; Lisha Wang ; Christopher M Rath ; Novartis Institutes for Biomedical Research, Emeryville, CA Internal Extractive Electrospray Ionization Mass Spectrometry based- Metabolomics for Lung Cancer Analysis; Yun Li ; Zhihao Wang ; Qian Li ; Yiping Wei ; Haiwei Gu ; Huanwen Chen ; East China Institute of Technology, Nanchang, China; Department of Cardiothoracic Surgery of Second Affiliated Hospital to Nanchang University, Nanchang, China; East China University of Technology, Nanchang, Mainland Study of Untargeted Metabolite Degradation in Plasma using Isotopic Ratio Outlier Analysis by uhplc- HRMS; Elizabeth Dhummakupt ; Casey Chamberlain ; Chris Beecher ; Timothy Garrett ; University of Florida, Gainesville, FL; Department of Pathology, University of Florida Gainesville, FL; IROA Technologies, Ann Arbor, MI A Step Forward in GC-HRAM-MS Based Metabolomics - A Novel Atmospheric Pressure GC-APCI Source Increases Quantitative and Qualitative Performance; Christian J. Wachsmuth ; Aiko Barsch ; Christoph Gebhardt ; Peter J. Oefner ; Katja Dettmer ; University of Regensburg, Institute of Functional Genomics, Regensburg, Germany; Bruker Daltonics Ltd, Bremen, Germany Novel Strategies for the Analysis of Isotopologue and Isotopomer Fractions of Primary Metabolites in C Based Metabolic Flux Analysis Experiments; Teresa Mairinger, ; Gunda Koellensperger ; Stephan Hann, ; Austrian Centre of Industrial Biotechnology (acib), Vienna, Austria; Department of Chemistry, University of Natural Resources and Life Sciences - BOKU Vienna, Vienna, Austria; Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria C-Metabolic Flux Analysis of Microbes by Using Novel Fragmentations of tert-butyldimethylsilyl (tbdms)-amino Acid Derivatives with GC-MS/MS.; Nobuyuki Okahashi ; Shuichi Kawana ; Junko Iida ; Hiroshi Shimizu ; Fumio Matsuda ; Osaka University, Suita, Japan; Shimadzu Corporation, Kyoto, Japan MP 467 MP 468 MP 469 MP 470 MP 47 MP 47 MP 47 MP 474 MP 475 MP 476 MP 477 Chromatography Tandem Mass Spectrometry System with Automated TMS Derivatization ; Shuichi Kawana ; Yumi Unno ; Yukihiko Kudo ; Takero Sakai ; Takashi Kobayashi 4 ; Shin Nishiumi 4 ; Masaru Yoshida 4 ; Noriyuki Ojima 5 ; Shimadzu Corporation, Osaka, Japan; Shimadzu Corporation, Kanagawa, Japan; Shimadzu Corporation, Kyoto, Japan; 4 Kobe University Graduate School of Medicine, Kobe, Japan; 5 Shimadzu Corporation, Tokyo, Japan LC-HRMS Metabolic Flux Analysis Reveals Mechanistic- Based Changes after Muscle AMPK Activation; John Kenji Meissen ; Russell Alan Miller ; Matt Blatnik ; Pfizer, Groton, CT; Pfizer, Cambridge, MA Metabolic Analysis of Single Human Cells in Different Mitotic Phases by Capillary Microsampling Electrospray Ionization Mass Spectrometry; Linwen Zhang ; Akos Vertes ; The George Washington University, Washington, DC Evaluating the Impact of Environmental Ultrafine Particles to Gut Bacterial Metabolism by targeted LC-MS/MS Metabolic Profiling; Julia Roubidoux ; Katie Schelli ; Joshua Rutowski ; Britt Holmén ; Jiangjiang (Chris) Zhu ; Department of Chemistry and Biochemistry, Miami University, Oxford, OH; Civil & Environmental Engineering, School of Engineering, University of Vermont, Burlington, VT Ion-pairing LC-MS with Automated Sample Prep for Metabolomics; Jason L. Richardson ; Bhavana Shah ; Zhongqi Zhang ; Amgen, Inc., Thousand Oaks, CA Application of Data-Dependent MS/MS in Structural Analysis of Isomeric Acylsugar Metabolites from Solanaceous Plants; Xiaoxiao Liu ; A. Daniel Jones, ; Department of Chemistry, Michigan State University, East Lansing, MI; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI Probiotic Lactobacillus Reuteri Strains Produce L-Ethionine via a Two-Carbon-Transferring Alternative Branch of the Folate Cycle; Daniel Röth ; Abby J Chiang ; Gabriel Gugiu ; James Versalovic ; Markus Kalkum ; City of Hope, Duarte, CA; Texas Children s Hospital, Baylor College Houston, TX Using Isotopic Ratio Analysis (IROA) and Nonnegative Matrix Factorization (NMF) to Sort Mixtures in Metabolomic Analyses; Chris Beecher ; Timothy J Garrett ; Elizabeth Dhummakupt ; Vanessa Y. Rubio ; IROA Technologies, Gainesville, Florida; University of Florida, Gainesville, FL MS Profiling of Molecular Composition Inside live D Artificial Tumors Using the Single-Probe Device; Wei Rao ; Ning Pan ; Haiqing Yu ; Xuewei Qu ; Chuanbin Mao ; Zhibo yang ; University of Oklahoma, Dept. of Chem & Biochem Norman, OK 5a-Reductase Type (SRD5A) 4--keto Steroid Metabolism Using Triple Quadrapole Mass Spectroscopy; sumankalai ramachandran; Department of Genitourinary Medical Oncology, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas., Houston, TX LC-SWATH/MS Metabolomics Platform with Hyphenation of Extraction and Analysis of Polar and Non-Polar Metabolites in Plasma and Urine; Michel Raetz ; Renzo Picenoni ; Guenter Boehm ; Gerard Hopfgartner ; University of Geneva, Geneva, Switzerland; CTC Analytics AG, Zwingen, Switzerland What Are We Eating? Differential Metabolomic Profiles Reveal an Insight into our Dietary Habits; Paul Clemens ; Baljit Ubhi ; SCIEX, Redwood City, CA MP 466 Analysis of Plasma Metabolites Using Gas- PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

81 MONDAY POSTERS MP 478 MP 479 MP 480 MP 48 MP 48 MP 48 MP 484 MP 485 MP 486 MP 487 MP 488 MP 489 MP 490 Molecular Network Analysis of Environmental Samples for Drug Discovery; Stefano Bonissone ; Natalie E Castellana ; Digital Proteomics, LLC. San Diego, CA Labeling of Specialized Metabolites in the Medicinal Plant Camptotheca acuminata using CO to Track Intermediates in the Biosynthetic Pathway; Sujana Pradhan ; Daniel A Jones ; Zhenzhen Wang ; Michigan State University, Haslett, MI; Michigan State University, East Lansing, MI Development of an LC-MS Method for the Kinetic Flux Profiling of a Diverse Set of Metabolic Pathways; Jay Kirkwood, ; Corey Broeckling, ; Jordan Steel, ; Becky Gullberg, ; Rushika Perera ; Jessica Prenni, ; Colorado State University, Fort Collins, CO; Proteomics and Metabolomics Facility, Fort Collins, Colorado [CO]; Arthropod-borne & Infectious Diseases Laboratory, Fort Collins, CO Δ9-THC Metabolites and Other Cannabinoid Detection; Toshi Ono ; Ken Tseng ; Tsunehisa Hirose ; Nacalai USA, San Diego, CA; Nacalai USA Inc., San Diego, CA - California; Nacalai Tesque Inc., Kyoto, Japan Determining Pentose Phosphate Pathway Metabolism in VHL (-) Clear Cell Renal Carcinoma (ccrcc); Collin Wetzel ; Megan Bischoff ; Johnson Chu ; Patrick A Limbach ; David R Plas ; Maria F Czyzyk-krzeska ; University of Cincinnati, Cincinnati, OH An Optimized Acquisition Database and LC-MS/MS Method Targeting Central Carbon Pathway Metabolites; Mark Sartain ; Amy Caudy, ; Adam Rosebrock, ; Agilent Technologies, Santa Clara, CA; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto ON, Canada Lanthanide-Chelator Barcode for Combinatorial Screening Applications; Todd Duncombe ; Kai Deng ; Paul D Adams ; Anup K Singh ; Trent R Northen ; Sandia National Laboratories, Albuquerque, NM; Lawrence Berkeley National Lab, Berkeley, CA Chromatographic performance for high resolution metabolomics; Vilinh Tran, ; Ken Liu, ; Dean Jones, ; Clinical Biomarker, Emory School of Medicine Atlanta, GA; Emory University School of Medicine, Atlanta, GA Development of Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Metabolomic Analysis of Small Numbers of Mammalian Cells; Xian Luo ; Liang Li ; University of Alberta, Edmonton, Alberta; University of Alberta, Edmonton, Canada Cow Milk Metabolome Profiling and Determination of its Dietary Effects on the Human Urine Metabolome Using Chemical Isotope Labeling LC-MS; Dorothea Mung ; Liang Li ; University of Alberta, Edmonton, Canada Metabolic Profiling of Human Sweat from Various Epidermal Locations Using Non-occlusive Sample Collection and Chemical Isotope Labeling LC-MS; Kevin Hooton ; Liang Li ; University of Alberta, Edmonton, Canada Metabolic Phenotyping of Platelet-Rich Plasma Using the AbsoluteIDQ p80 kit; Lisa St John Williams ; Guido Dallmann ; Will J Thompson ; Therese Koal ; Duke University Medical Center, Durham, NC; Biocrates Life Science AG, Innsbruck, Austria Metabolomic Analysis of C/5N Labeled Metabolites Utilizing High Resolution OrbitrapTM Mass Spectrometry and Compound Discoverer Software; Anastasia Kalli ; Bryson Bennett ; Junhua Wang ; Caroline Ding ; Ralf Tautenhahn ; Thermo Fisher Scientific, San Jose, CA; Calico Labs, South San Francisco, CA MP 49 MP 49 MP 49 MP 494 MP 495 MP 496 MP 497 MP 498 MP 499 MP 500 MP 50 Development of Ion Pair-Reverse Phase Chromatography Mass Spectrometry Method to Maximize Isomer Separation and Coverage of Endogenous Metabolite Classes; Yuqin Dai; Agilent Technologies, Santa Clara, CA Formate Tetrahydrofolate Ligase of Lactobacillus reuteri: A Multifaceted Player of the Folate Cycle?; Abby Chiang ; Daniel Röth ; James Versalovic ; Markus Kalkum ; City of Hope, Duarte, CA; Texas Children s Hospital, Baylor College Houston, TX Development of MRM-Based Detection of the Plant Metabolome Using Liquid Chromatography/Tandem Mass Spectrometry; Satoshi Yamaki ; Junichi Masuda ; Yoshihiro Hayakawa ; Muneo Sato 4 ; Yuji Sawada 4 ; Masami Yokota Hirai 4 ; Shimadzu Corporation, Kanagawa, E; Shimadzu Corporation, Kanagawa, Japan; Shimadzu Corporation, Kyoto, Japan; 4 RIKEN, Yokohama, Japan Fractionation and Untargeted Metabolomics of Human Plasma by Off-Line Coupling of Reversed-Phase and Hydrophilic Interaction Liquid Chromatography LC/MS; Stefanie Wernisch ; Subramaniam Pennathur, ; University of Michigan, Ann Arbor, MI; University of Michigan Medical School, Ann Arbor, MI Wine Flavonoids Identified and Analyzed by Composite Neutral Loss Scan and Novel Data-Dependent Scans for Metabolomics Discovery by LC/MS/MS; Bennett Kalafut ; Rae Ana Snyder ; Mark Dreyer ; Thermo Fisher Scientific, San Jose, CA Microorganisms: Identification and Characterization Utility of Random Forest Combined with Infusion Electrospray MS and MALDI-TOF MS for Rapid Classification of Neisseria Meningitidis Strains; Adrian R Woolfitt ; Hercules Moura ; Bryan A Parks ; Ramnath Gowrishankar ; Conrad P Quinn ; Brian H Harcourt ; Xin Wang ; John R Barr ; CDC, Atlanta, GA Identification of Microorganisms in Biofluids and Saliva of Individuals with Periodontitis and Chronic Kidney Disease Using MALDI Biotyper; Levy Anderson Cesar Alves ; Rafael Celestino Souza ; Taciana Mara Couto Silva ; Marcelo Fava ; Meriellen Dias ; Maria Anita Mendes ; Ana Lidia Ciamponi ; Orthodontics and Paediatric Department Dental School University of São Paulo, Sao Paulo, SP - BR; Paediatric Nephrology Department Medical School University of São Paulo (USP), Sao Paulo, SP/BRAZIL; LSCP - Chemical Engineering Department - Polytechnics School University of São Paulo (USP), Sao Paulo, SP/ Brazil A Peptide-Based LC-MS/MS Method for Detection and Identification of Salmonella serovars; Shu-Hua Chen ; Christine H. Parker ; Melinda A. McFarland ; Timothy R Croley ; FDA/CFSAN, College Park, MD Detection of Penicillin Binding Protein a for the Identification of Methicillin Resistant S.aureus Using Top-down Proteomics; Jason Neil ; James Jr L Stephenson ; Alexander Cherkassky ; Thermo Fisher Scientific, Cambridge, MA; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, San Jose CA, CA Reliable Biomarkers for Identification of Mycobacterium Tuberculosis Complex in Broth Culture Media with Nanodiamond; Hsi-An Chen ; Ya-Chin Chin ; Po-Chi Soo ; Wen-Ping Peng ; National Dong Hwa University, Shoufeng Hualien, Taiwan; Tzu Chi University, Hualien, Taiwan Deciphering Multifactorial Resistance in Acinetobacter baumannii Combining Whole-Genome Sequencing and Targeted Label-Free Proteomics; Tiphaine Cecchini ; Eun- Jeong Yoon ; Corinne Beaulieu ; Yannick Charretier ; Chloe Bardet ; Xavier Lacoux ; Zack Blair ; Patrice Courvalin ; 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 8

82 GENERAL MONDAY INFORMATION POSTERS MP 50 MP 50 MP 504 MP 505 MP 506 MP 507 MP 508 MP 509 MP 50 MP 5 MP 5 Jerome Lemoine 4 ; Catherine Grillot-Courvalin ; Jean- Philippe Charrier ; Biomerieux, Marcy L Etoile, France; Institut Pasteur, Paris, France; biomerieux, Saint Louis, Missouri; 4 ISA, Unit 580 CNRS/UCBL- Villeurbanne, France Novel Genetic Determinants for Complex Head Composition in a Giant Salmonella Phage; Susan T Weintraub ; Adriana Coll ; Martine Bosch ; Kevin Hakala ; Sammy Pardo ; Dana Molleur ; Stephen C Hardies ; Lindsay W Black 4 ; Julie A Thomas ; Univ. of Texas HSC, San Antonio, TX; Rochester Institute of Technology, Rochester, NY; Thermo Fisher Scientific, San Jose, CA; 4 University of Maryland School of Medicine, Baltimore, MD Thermal Desorption Electrospray/Ionization Mass Spectrometry Combined with Principal Component Analysis for Rapid Characterization of Bacterial Species; Shiang Jiun Lin ; Sung Pin Tseng ; Hung Su ; Yang Kuang Pan ; Jentaie Shiea ; National Sun Yat- Sen University, Kaohsiung, Taiwan; Kaohsiung Medical University, Kaohsiung, Taiwan Application of Matrix-Assisted Laser Desorption/ Ionization Time-Of-Flight Mass Spectrometry for Differentiation of Cacao Phytopathogen Strains Growing in Different Tissues and Hosts; Fábio Santos ; Alessandra Tata ; Kátia Belaz ; Dilze Magalhães ; Edna Luz ; Marcos Nogueira Eberlin ; University of Campinas, Campinas SP, Brazil; CEPLAC, Ilhéus Bahia, Brazil MALDI Profiling of Cyanobacteria by Monitoring Large Molecules; Hirohiko Asukabe ; Takuma Nakayama ; Ken-ichi Harada ; Susumu Y. Imanishi ; Meijo University, Nagoya, Japan; Meijo University, Nagoya, Aichi Identification of Fungi using Rapid Evaporative Ionisation Mass Spectrometry; Frances Bolt ; Simon Cameron ; Ali Abdolrasouli ; Johanna Rhodes ; Tony Rickards ; Kate Hardiman ; Adam Burke ; Julia Balog ; Tamas Karancsi ; Daniel Simon ; Richard Schaffer ; Zsolt Bodai ; Monica Rebec ; Zoltan Takats ; Imperial College, London, United Kingdom; Imperial College Healthcare Trust, London, UK; Waters Research Center, Budapest, Hungary Identification and Species Delineation of Bacteria Using MALDI-TOF MS Based on Ribosomal Protein Sequences in DNA Databases; Kenneth Parker; SimulTOF/ VIC Instruments, Marlborough, MA Differentiation of Bacteria at the Strain Level by MALDI- MS of Proteins >5kDa; Franco Basile ; Anthony Maus ; Bledar Bisha ; University of Wyoming, Laramie, WY Liquid Extraction Surface Analysis Mass Spectrometry for Protein Analysis Directly from Escherichia coli and Staphylococcus epidermidis; Klaudia I Kocurek, ; Josephine Bunch ; Robin C May ; Helen J. Cooper ; University of Birmingham, Birmingham, United Kingdom; National Physical Laboratory, Teddington, United Kingdom High-velocity Impact Survival and Bouncing Kinetics of Electrosprayed Bacterial Spores Studied using Novel Asymmetric Image Charge Detectors; Brandon Barney ; Daniel Austin ; Brigham Young University, Provo, UT Probing Protein Interaction Dynamics between Asian Citrus Psyllid and Candidatus Liberibatcter asiaticus by Chemical Crosslinking Mass Spectrometry; Xuefei Zhong ; John Ramsey, ; Juan Chavez ; Arti Navare ; Jared Mohr 4 ; Michelle Cilia,, 4 ; James Bruce ; University of Washington, Seattle, WA; USDA Agricultural Research Service, Ithaca, NY; Boyce Thompson Institute for plant research, Ithaca, NY; 4 Cornell University, Ithaca, NY High Yielding Spin Column Isolation of Total Proteins from Microbial Cultures for Proteomic Applications; Victoria Nieciecki ; Heather Callahan ; Eddie Adams ; MO BIO Laboratories, Carlsbad, CA - California; MO BIO Laboratories, Carlsbad, CA MP 5 MP 54 MP 55 MP 56 MP 57 Simultaneous DNA, RNA, and Protein Extraction from Microbial Cells: Sequential Isolation of Complex Biomolecules from a Single Source; Heather Callahan ; Victoria Nieciecki ; Eddie Adams ; MO BIO Laboratories, Carlsbad, CA Characterizing the Formation of Electrophilic Fatty Acid Derivatives During Influenza Infection and Determining their Role in Pathogenesis; Greg Buchan; University of Pittsburgh, Pittsburgh, PA Integrated Omics Reveals Dynamic Nature of the Arabidopsis Rhizosphere Microbiome; Ljiljana Pasa-Tolic ; Abigail Ferrieri ; Charles K. Ansong ; Heather M. Brewer ; Angela D. Norbeck ; Yaya Cui ; Christopher Staley 4 ; Malak Tfaily ; Rosalie Chu ; Jared Shaw ; Meng L. Markillie ; Richard A. Ferrieri ; Susannah G. Tringe 5 ; Michael J. Sadowsky 4, 6 ; Gary Stacey ; Battelle - PNNL, Richland, WA; Pacific Northwest National Laboratory, Richland, WA; University of Missouri, Columbia, MO; 4 University of Minnesota, St. Paul, MN; 5 DOE Joint Genome Institute, Walnut Creek, CA; 6 University of Minnesota at Twin Cities, Saint Paul, MN Development of Metaproteomics Methods for Characterization of Soil Microbial Communities; ZHOU LI ; Cristina N. Butterfield ; Susan Spaulding ; Brian C. Thomas ; Andrea Singh ; K. Blake Suttle ; Robert Hettich ; Jillian Banfield ; Chongle Pan ; Oak Ridge National Laboratory, Oak Ridge, TN; University of California, Berkeley, CA; University of California, Santa Cruz,, Santa Cruz, CA Non-Targeted Mass Spectrometry-based Analysis for the Differentiation of Pathogenic Escherichia coli Strains; Rabih Jabbour ; Raja Sekhar Nirujogi ; Kim Min- Sik ; Mary M Wade 4 ; Babylakshmi Muthusamy 5 ; Gajanan J. Sathe 5 ; T.S. Keshava Prasad 6, 7 ; Akhilesh Pandey, 8 ; ECBC, APG, MD; Institute of Bioinformatics, International Technology Park, Bangalore, India; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; 4 ECBC, Apg, MD; 5 Institute of Bioinformatics, Bangalore, India; 6 Institute of Bioinformatics, Banglore, India; 7 Centre for Bioinformatics, Pondicherry University, Puducherry, India; 8 Department of Biological Chemistry, Pathology, Oncology, Johns Hopkins University School of Medicine, Baltimore, MD Phosphopeptides: Enrichment Methods MP 58 Enrichment and Identification of MHC-Associated Phosphopeptide Neoantigens in Hepatocellular Carcinoma for the Development of Novel Cancer Immunotherapeutics; Paisley Myers ; Nico Buttner ; Jennifer G Abelin ; Sarah A. Penny ; Lora G Steadman ; Dina L. Bai ; Mark Cobbold ; Jeffrey Shabanowitz ; Donald F Hunt ; University of Virginia, Charlottesville, VA; University of Birmingham, Birmingham, UK; Harvard University, Boston, MA MP 59 Phosphoproteome Changes in Altered Cholesterol Metabolism Revealed by SCX Tip Based Fractionation of Batch-Enriched Phosphopeptides; Alireza Dehghani ; Markus Gödderz ; Volkmar Gieselmann ; Dominic Winter ; University of Bonn, Bonn, Germany MP 50 Development of Enrichment Strategies for the Analysis of Phosphohistidine-Containing Peptides; Gemma E Hardman ; Claire E Eyers ; University of Liverpool, Liverpool, United Kingdom MP 5 Enrichment of Phosphorylated Peptides Using Metal-Loaded Polymeric Reverse Micelles for MALDI- MS Analysis; Meizhe Wang ; Bo Zhao ; Sankaran Thayumanavan ; Richard Vachet ; University of Massachusetts Amherst, Amherst, MA PAGE 8 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

83 MONDAY POSTERS MP 5 MP 5 MP 54 MP 55 MP 56 MP 57 MP 58 MP 59 MP 50 Fabrication of MnFeO4 Magnetic Nanoparticles for the Enrichment of Phosphopeptides in Combination with Mass Spectrometric Analysis; Yung-Yun Huang ; He-Hsuan Hsiao ; Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan; Department, of Chemistry, National Chung-Hsing University, Taichung, Taiwan Dual Wield nanolc-esi-ms for Simultaneous Detection of Singly and Multiply Phosphorylated Peptides; Chia- Feng Tsai ; Kosuke Ogata ; Masaki Wakabayashi ; Naoyuki Sugiyama ; Yasushi Ishihama ; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan Metal Ion-Immobilized Magnetic Nanoparticles for Global Enrichment and Identification of Phosphopeptides by Mass Spectrometry; Yangjun Zhang, ; Rui Zhai ; XiaoHong Qian ; Beijing Proteome Research Ctr, Beijing, Beijing; Beijing Institute of Radiation Medicine, Beijing, C.N. Excellent Sensitivity through Excellent Recovery ERLIC Outperforms TiO Affinity Purification in Quantitative Phosphoproteomics with Low Sample Amounts; Stefan Loroch ; Albert Sickmann,, ; René P Zahedi ; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.v., Dortmund, Germany; Ruhr-Universität- Bochum, Medizinische Fakultät, Bochum, Germany; University of Aberdeen, School of Natural & Computing Sciences, Aberdeen, Scotland ESI Tandem Mass Spectrometric Analysis of Phosphopeptide Modified by Cyclic Quaternary Ammonium Tags; Hye Kyong Kweon ; Kristina Hakansson ; Philip Andrews ; University of Michigan, Ann Arbor, MI Method Development and Evaluation of the Protein Phosphatase Phosphoproteome Using the Chip ifunnel QTOF Platform; Brooke Thompson ; Vadiraja Bhat ; Chelsea E. Cunningham ; Paulos Chumala ; Frederick S. Vizeacoumar ; Franco J. Vizeacoumar ; George S. Katselis ; CCHSA/Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Agilent Technologies, Wilmington, DE; Department of Pathology, Cancer Cluster, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada Acid-Based SCX Fractionation for In-Depth Proteome and Phosphoproteome Analysis; Jun Adachi ; Hashiguchi Kazunari ; Nagano Maiko ; Sato Misako ; Sato Ayako ; Fukamizu Kazuna ; Ishihama Yasushi ; Tomonaga Takeshi ; National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka; National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan; Kyoto University, Kyoto, Japan Two-Step Elution of Phosphopeptides from TiO Microparticles an Improved Detection of Multiphosphorylated Peptides; Rudolf Kupcik ; Pavel Rehulka ; Ivo Fabrik ; Jana Klimentova ; Helena Rehulkova ; Jiri Stulik ; Pavla Krulisova ; Zuzana Bilkova ; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic; Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic Polymers Characterization of Bromine Functionalized Alternating and Random Copolyesters by Tandem Mass Spectrometry; Selim Gerislioglu ; Xianglin Yin ; Coleen Pugh ; Chrys Wesdemiotis ; The University of Akron, Akron, Ohio; The University of Akron, Akron, OH MP 5 MP 5 MP 5 MP 54 MP 55 MP 56 MP 57 MP 58 MP 59 MP 540 MP 54 MP 54 MP 54 MP 544 The Characterization of Polymeric Methylene Diphenyl Diisocyanates (PDMIs) Using UHPSFC and FT-ICR APPI- MS; Julie M Herniman ; Robert Carr ; John G Langley ; University of Southampton, Southampton, United Kingdom; Huntsman (Europe), bvba, Everborg, Belgium An APCI LC-MS-MS Method for the Determination of Octamethylcyclotetrasiloxane (D4), Decamethylcyclopentasiloxane (D5), and Dodecamethylcyclohexasiloxane (D6) in Silicone Emulsions.; Ron Tecklenburg ; Tanya M Habitz ; Dow Corning Corporation, Auburn, MI Simplification of Polysorbate 80 Spectrum: Selective Removal of Metal Cation Adducts from Polymers via Gas-Phase Ion/Ion Reactions Using Carborane Anions; Stella Betancourt ; Alice L Pilo ; Jiexun Bu ; Scott A McLuckey ; Purdue University-Department of Chemistry, West Lafayette, IN Self-Assembly and Characterization of D to D Supramolecular Star of David Using Mass Spectrometry; Bo Song ; Xiaopeng Li ; Ming Wang ; Texas State University, San Marcos, TX Analysis for Extractable and Leachable Compounds from Polymeric Materials; Gordon Fujimoto ; Sarah Dowd ; Baiba Cabovska ; Marian Twohig ; Waters Corporation, Beverly, MA; Waters Corporation, Milford, MA Identification of Poly Ethylene Glycol (PEG) and PEGylated Detergents Using Protein Search Engines; Shiva Ahmadi ; Dominic Winter ; University of Bonn, Bonn, Germany Assembling and Characterization of Discrete Supramolecular Fractal Architectures Using ESI-MS and Ion Mobility-Mass Spectrometry ; Yuanfang Ying ; Ming Wang ; Kendall Williams ; Xiaopeng Li ; Texas State University, San Marcos, TX Mass Spectrometry Characterization of Isomeric Biodegradable Polyesters; sahar sallam ; Chrys Wesdemiotis ; Yuanyuan Luo ; Mathew L. Becker ; The University of Akron, Akron, OH Surface Composition of Films Made from Partially Functionalized Polymer Blends; Kevin Endres ; Jacob A. Hill ; John Meyerhofer ; Qiming He ; Chrys Wesdemiotis ; Mark D Foster ; The University of Akron, Akron, OH; Saint Vincent College, Latrobe, PA MALDI-MS Signal Enhancement of Peptides from Donor-Acceptor Interactions between Amphiphilic Polymers and MALDI Matrix; Mahalia Serrano ; Huan He ; Sankaran Thayumanavan ; Richard W Vachet ; University of Massachusetts Amherst, Amherst, Massachusetts Investigating the Effect of Sample Preparation Parameters on the Cationization of Synthetic Polymers Using Matrix-Assisted Laser Desorption Ionization; Michelle Piotrowski ; Kevin Owens ; Drexel University, Philadelphia, PA Revealing Topological Isomers Inside Insoluble Cyclo- Para-Phenylenes by Ion Mobility Mass Spectrometry; Hans Joachim Raeder ; Wen Zhang ; Ali Abdulkarim ; Klaus Müllen ; MPI for Polymer Research, Mainz, Rhineland- Palatinate; MPI for Polymer Research, Mainz, Germany Matrix Assisted Laser Desorption Ionization Mass Spectrometry and NMR Characterization of Plasma Polymerized Styrene; Lee Elliott ; Kris Micheal Kirmess ; Gary Ray Kinsel ; Southern Illinois University Carbondale, Carbondale, IL Highly Sensitive Analysis of Residual Monomers in Adhesives Using HSGC/MS; Sanket Chiplunkar ; Durvesh Sawant ; Dheeraj Handique ; Prashant Hase ; Ankush Bhone ; Ajit Datar ; Jitendra Kelkar ; Pratap Rasam ; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, Maharashtra; Shimadzu Analytical (India) Pvt. Ltd., 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 8

84 GENERAL MONDAY INFORMATION POSTERS MP 545 MP 546 MP 547 MP 548 MP 549 MP 550 MP 55 MP 55 MP 55 MP 554 Mumbai, India Polymer and Adhesive Tape Analysis by Thermal Desorption and Pyrolysis Combined with Direct Analysis in Real Time (DART) Mass Spectrometry; Cody Robert B. ; Chikako Takei ; Haruo Shimada ; Yasuo Shida 4 ; Akihiko Kusai 5 ; JEOL USA, Inc. Peabody, MA; BioChromato, Inc. Fujisawa, Japan; Shiseido Research Center, Yokohama, Japan; 4 University of Yamanashi, Kofu, Japan; 5 JEOL Ltd., Akishima, Japan Polymer Structure Investigation by Trapped Ion Mobility Mass Spectrometry; Jan Jordens ; Ynze Mengerink ; Esra Altuntas ; Mark E Ridgeway ; Melvin Park ; Maarten Honing, ; DSM Resolve, Geleen, Netherlands; Bruker Daltonic, Billerica, MA; VU University, Amsterdam, Netherlands Improved Characterization of Complex Mixtures via Liquid Chromatography/Charge Reduction/Mass Spectrometry (LC/CR/MS); John Stutzman ; Matthew C Crowe ; James IV N Alexander ; Bruce Bell ; Melissa N Dunkle ; The Dow Chemical Company, Midland, MI; The Dow Chemical Company, Collegeville, PA; The Dow Chemical Company, Terneuzen, NL Characterization of Unknown Surfactant Packages in Industrial Samples by Liquid Chromatography Mass Spectrometry (LC/MS) with Electrospray Ionization (ESI); Dale Willcox ; Noelle Elliott ; Intertek, Allentown, PA Proteins: General and Membrane Biophysical Characterization of the Interactions between Membrane Proteins and Lipids; Xiao Cong ; Yang Liu ; Wen Liu ; David H Russell ; Arthur Laganowsky,, ; Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX; Department of Chemistry, Texas A&M University, College Station, TX; Department of Microbial Pathogenesis & Immunology, College of Medicine, Texas A&M Health Science Center, Bryan, TX Protein Mass Spectra Database for Rapid Identification of Field-Caught Phlebotomine Sand Flies; Kristyna Hlavackova ; Daniel Kavan ; Vit Dvorak ; Petr Volf ; Petr Halada ; Department of Parasitology, Charles University in Prague, Prague, Czech Republic; Institute of Microbiology CAS, Prague, Czech Republic Developments in Analysis of GPCRs: Monitoring Protein Movement by Means of Mass Spectrometry; Krzysztof Okrasa ; James Errey ; Rob Cooke ; Heptares Therapeutics Ltd., Welwyn Garden City, UK Improving the Efficiency and Rapidity of Tryptic Proteolysis: from Blood to Unknown Stains ; Ekta Patel ; Paola Cicatiello ; Lisa Deininger ; Malcolm R Clench ; Peter Marshall ; Andy West ; Simona Francese ; Centre for Mass Spectrometry Imaging, Biomolecular Research Centre, Sheffield, South Yorkshire; Universita di Napoli Federico II, Dipartimento di Scienze Chimiche, Naples, Naples; GlaxoSmithKline, Stevenage, UK How Sequence Variant Analysis can be Hampered by Trypsin Side Reactions; Georg Drabner ; Marco Boettger ; Roche Innovation Center Penzberg, Penzberg, Germany Mass spectrometry of Collagen and Casein in the Remains of the 5th to 7th Century Bamiyan Buddhas; Takashi Nakazawa ; Kazuki Kawahara ; Shunsuke Fukakusa ; Mao Karino ; Miho Takashima 4 ; Yoko Taniguchi 5 ; Nara Women s University, Nara, Nara; Osaka University, Suita, Japan; Nara Women s University, Nara, Japan; 4 The National Museum of Western Art, Tokyo, Japan; 5 University of Tsukuba, Tsukuba, Japan MP 555 MP 556 MP 557 MP 558 MP 559 MP 560 MP 56 MP 56 MP 56 MP 564 Proteomic Characterization of Cell Architecture and its Preparatory Biochemical Extractions; Li-Hua Li ; Cheng- Chih Richard Hsu ; Cheng-Hsien Yang ; Chen Meng 4 ; Yeou-Guang Tsay, 5, 6 ; Taipei Veterans General Hospital, Taipei, Taiwan; Department of Chemistry National Taiwan University, Taipei, Taiwan; Institute of Biochemistry and Molecular Biology, Taipei, Taiwan; 4 Chair of Proteomics and Bioanalytics Technische Universitaet Muenchen, Munich, Germany; 5 Proteomics Research Center, Taipei, Taiwan; 6 Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan The Interactions between N-Heterocyclic Carbene Silver Complex and Cytochrome C Studied by Electrospray Ionization Mass Spectrometry; Yan Pan;, Morgantown, WV A Chemical Proteomic Method for the Discovery of Novel LPA-binding Proteins; Xuejiao Dong ; Yinsheng Wang ; University of California - Riverside, Riverside, CA Exploring the Differences in Endocytic Vesicles with the Aid of Mass Spectrometry Based Protein and Lipid Profiling; Bini Ramachandran ; Krishnamurthy H ; Satyajit Mayor, 4 ; National Centre for Biological Sciences, Bangalore, India, Bangalore, Karnataka; Centre for Imaging and Flow Cytometry Facility, National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK, Bangalore, India; National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK, Bangalore, India; 4 Institute for Stem Cell Biology and Regenerative Medicine, Bellary Road,, Bangalore, India Quality by Design (QbD) Based Development of a Peptide Mapping UPLC Method for Recombinant Human Serum Albumin (rhsa); Ashraf Madian ; Irish Gibson ; Janet G. De Los Reyes ; Cassandra Norton 4 ; Shen Chen 5 ; Lisa Cherry ; Global Technology Services, Hospira, a Pfizer Company, Lake Forest, IL; OneOne Global Pharmaceutical R and D, Hospira, a Pfizer Company, McPherson, KS; Global Established Products R and D, Hospira, a Pfizer Company, McPherson, KS; 4 Global Technical Supply, Hospira, a Pfizer Company, McPherson, KS; 5 OneOne Global Pharmaceutical R and D, Hospira, a Pfizer Company, Lake Forest, IL Using LC-MS Based Methods for Testing the Digestibility of a Non-Purified Membrane Protein in Simulated Gastric Fluid; Wayne Skinner, ; Brett S Phinney ; Anthony Herren ; John Goodstal ; Isabel Dicely ; Daniel Facciotti ; Arcadia Biosciences, Davis, CA; Arcadia Biosciences, Davis, Davis, CA; Proteomics Core Facility, University of California, Davis, CA 9566, USA, Davis, CA Using UHPLC-ESI-HRMS to Detect Small Mass Differences in High Molecular Weight Glutenin Subunits of Wheat; Ray Bacala ; Dave Hatcher ; Canadian Grain Commission, Winnipeg, MB; Canadian Grain Commission, Winnipeg, Canada Towards a Prediction of Protein Reactivity Against Electrophile Ligands:. Ranking Amino Acid Side Chain Nucleophilicities; Guillaume Gabant ; Yoann Richer ; Solène Motteau ; Emmanuelle Mebold ; Martine Cadene ; CBM CNRS UPR40, Orleans, France; IMMM CNRS UMR 68, Le Mans, France Evaluation of N-terminal Labeling Protocols for Determination of Protein Cleavage Sites by Mass Spectrometry; Michelle Gadush ; Maria D. Person ; University of Texas at Austin, Austin, TX Identification of Unique Rod Outer Segment Plasma Membrane Proteins Using a Label-Free Protein Correlation Profiling; Nikolai P Skiba ; Vadim Y Arshavsky ; Albert Eye Research Institute, Duke University Medical Center, Durham, NC PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

85 MONDAY POSTERS MP 565 MP 566 MP 567 MP 568 MP 569 MP 570 MP 57 MP 57 MP 57 MP 574 MP 575 MP 576 MP 577 Identification of Polyglutamylation of C-Terminal Tails of Tubulins from In-Gel Double Digests with Trypsin and Subtilisin; Hang-Gyeong Chin ; Colleen McClung ; Sriharsa Pradhan ; Christopher J. Noren ; Cristian I. Ruse ; New England Biolabs, Ipswich, MA Disulfide Bond Reduction on TiBlue Electrodes a Breakthrough in Protein Analysis; Jean-Pierre Chervet ; Agnieszka Kraj ; Hendrik-Jan Brouwer ; Nico Reinhoud ; Martin Eysberg ; Antec, Zoeterwoude, -; Antec, Zoeterwoude, The Netherlands; Antec LLC, Boston, MA Rapid Analysis of Proteins on High-Resolution Mass Spectrometers Using Matrix-Assisted Ionization; Shameemah Thawoos ; Casey Daniel Foley ; James Wager-Miller ; Ken Mackie ; Paul Stemmer ; Sarah Trimpin ; Wayne State University, Detroit, MI; Indiana University Dept. Chemistry, Bloomington, IN A New Thiol Derivatization Reactions with,,-benzotelluradiazole Studied by Mass Spectrometry; Chang Xu ; Qiuling Zheng ; Kehua Xu ; Bo Tang ; Hao Chen ; Ohio University, Athens, OH; Shandong Normal University, Jinan, SD Native Mass Spectrometry Analysis of Membrane- Bound Reaction Center from Blastochloris viridis; Yue Lu ; Zhang Hao, ; Michael L Gross ; Robert E Blankenship ; Washington University in St. Louis, St. Louis, MO Improved Proteolytic Digestion under High Pressure Cycling: Rapid Digestion with Improved Sensitivity and Sequence Coverage; Vera S. Gross ; John Wilson ; Alexander Lazarev ; Pressure BioSciences, South Easton, MA; Protifi, LLC, Huntington, NY Fully Automated Digestion, Separation and Analysis of the Human Prolactin Receptor Transmembrane Protein by LC-MS/MS; Joshua Emory ; Nishi Rochelle ; Boutaghou Nazim ; Feild J Brian ; Shimadzu Scientific Instruments, Inc. Columbia Proteins: PTMs (Part ) Proteomic Analysis of Protein S-Sulfhydration in Staphylococcus aureus; Yixiang Zhang, ; Hui Peng, ; David Peter Giedroc, ; Jonathan Cyboski Trinidad, ; Department of Chemistry, Indiana University, Bloomington, IN; Laboratory for Biological Mass Spectrometry, Indiana University, Bloomington, IN; Department of Molecular and Cellular Biochemistry,Indiana University, Bloomington, IN Deep Coverage of the Mouse Cysteine Sulfenome in vivo; Shin-Cheng Tzeng ; Sjoerd Van der Post ; Nelmi O Devarie-Baez ; Cristina M Furdui ; Jason Held ; Washington University in St. Louis, St. Louis, MO; Wake Forest School of Medicine, Winston-Salem, NC Quantifying Oxidation in Peptides Containing Multiple Methionine Residues; Joshua T Shipman ; Eden P Go ; Heather Desaire ; University of Kansas, Lawrence, KS Quantifying Reversible Oxidation of Protein Thiols in Arabidopsis thaliana; Evan Mc Connell ; Leslie M Hicks ; University of North Carolina, Chapel Hill, NC Energetics of S-Palmitoylation: Role of Proline and Neighboring Cysteines; Neelam Khanal ; Vikas Pejaver ; Zhiyu Li, ; Predrag Radivojac ; David E Clemmer ; Suchetana Mukhopadhyay ; Indiana University Dept. Chemistry, Bloomington, IN; Novilytic, West Lafayette, IN; Indiana University, Bloomington, IN Elevated Level of S-Glutathionylation of Hemoglobin in Mole-Rats Determined by LC-MS; Kuanysh Kabytaev ; Christiane Vole ; Dmitriy Shin ; Philip Dammann ; Alexandre Stoyanov ; Department of Pathology & Anatomical Sciences, University of Missouri, Columbia, MO; Department of General Zoology, University of Duisburg- Essen, Essen, Germany MP 578 MP 579 MP 580 MP 58 MP 58 MP 58 MP 584 MP 585 MP 586 MP 587 MP 588 MP 589 Difference Gel Electrophoresis for Phosphoproteomics (DiGEP); Mayank Srivastava ; Linna Wang ; Weiguo Andy Tao ; Purdue University, West Lafayette, IN Intact Phosphorylated Protein Analysis by Microfluidic CE-ESI-MS; Esme Candish ; Michael E Pacold ; Scott Mellors ; Michael J Ramsey ; University of North Carolina at Chapel Hill, Chapel Hill, NC; Whitehead Institute for Biomedical Research, Cambridge, MA; 908 Devices Inc., Boston, MA Elucidating Kinase Substrate Networks in Chlamydomonas reinhardtii; Alex Chao ; Chris A Broberg ; Megan C Connor ; Leslie M Hicks ; UNC Chapel Hill, Department of Chemistry Chapel Hill, NC Studies of the Molecular Mechanisms in the Regulation of PRL- Phosphatase Activity in the Endothelial Cells; Xinggui Shen ; Christopher G. Kevil ; LSU Health- Shreveport, Shreveport, LA Phosphoproteomic Evaluation of Chimeric Proteins; Katelyn Ludwig ; Nirmalya Sen ; Natasha J Caplen ; Amanda B Hummon ; University of Notre Dame, Notre Dame, IN; NIH, Bethesda, MD The Functions of Serine 687 Phosphorylation of Human DNA Polymerase h in UV Damage Tolerance; Xiaoxia Dai ; Changjun You ; Yinsheng Wang ; UC Riverside, Riverside, CA Phosphorylation Dynamics and Interacting Proteins of MAP Kinase 4 Revealed by Proteomics; Tong Zhang ; Jacqueline D Schneider ; Craig P. Dufresne ; Alice C Harmon ; sixue chen ; University of Florida, Gainesville, FL; University of Florida, Gainesville, Florida; Thermo Fisher Scientific, West Palm Beach, FL Perturbation of the Phosphoproteome of Colony Stimulating Factor Receptor (CSFR) in Normal Myeloid Development, Myeloid Leukemia and Neutrophilic Leukemia; Pankaj Dwivedi ; David Muench ; Mohammad Azam ; Harry Leighton Grimes ; Kenneth D Greis ; University of Cincinnati, Cincinnati, OH; Cincinnati Children s Hospital Medical Center, Cincinnati, OH A Panoramic Survey of Cellular Signaling in Human Gastric Cancer Cells by Monitoring both Phosphotyrosine and Acetyl-Lysine Post-Translational Modifications; Jeffrey C Silva ; Cammarata John ; Hamza Ghaith ; Manor Askenazi ; Jun Zhu ; Zhongyi Cheng ; Lighthouse Proteomics, Beverly, MA; Adeptrix Corporation, Beverly, MA; PTM BioLab (Hangzhou) Co. Ltd, Hangzhou, China Updating and Expanding the PTM Catalog of Acid- Soluble Tau: A Case for Multiplexed Proteomic Analysis; Gogce Crynen ; Robert Pelot ; Craig P Dufresne ; Jon M Reed ; Prashanthi Vallabhaneni ; Benoit Mouzon ; Laila Abdullah ; James E Evans ; Fiona Crawford ; Roskamp Institute, Sarasota, FL; Thermo Fisher Scientific, West Palm Beach, FL Identification of Cross-Linked Peptides in Proteins Subjected to Photo-Oxidation; Michele Mariotti ; Fabian Leinisch ; Diana Julie Oersnes-Leeming ; Michael J Davies ; Birte Svensson 4 ; Per Hägglund 4 ; Technical University of Denmark, Kongens Lyngby, Denmark; University of Copenhagen, Copenhagen, Denmark; Nordic Bioscience, Herlev, Denmark; 4 Technical University of Denmark, Lyngby, Denmark msviz, a Zero Learning Curve Graphical Software Tool for Detailed Manual Validation and Quantitation of Post- Translational Modifications; Manfredo Quadroni ; Roman Mylonas ; Trinidad Martin Campos, ; Alexandre Masselot ; Patrice Waridel ; Ioannis xenarios ; CIG - University of Lausanne, Lausanne, Switzerland; Vital-IT Group - Swiss Institute of Bioinformatics, Lausanne, Switzerland; University of Geneva, Geneva, Switzerland 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 85

86 GENERAL MONDAY INFORMATION POSTERS MP 590 MP 59 MP 59 MP 59 MP 594 MP 595 MP 596 Sequential Immunoaffinity Purification of Post- Translationally Modified Peptides for Improved Enrichment Specificity; Matthew P. Stokes ; Charles L Farnsworth ; Jian Min Ren ; Kimberly A Lee ; Xiaoying Jia ; Hongbo Gu ; Vicky Yang ; Cell Signaling Technology, Inc. Danvers, MA Metabolomics-Assisted Proteomics Reveals the Function of Lysine Succinylation and SIRT5 in Regulation of β-oxidation of Long-Chain Fatty Acids; Sushabhan Sadhukhan ; Xiaojing Liu ; Ornella D Nelson ; John A Stupinski ; Sheng Zhang ; Robert S Weiss ; Jason W Locasale ; Hening Lin ; Cornell University, Ithaca, NY; Cornell University, New York, NY Mass Spectrometry Based Identification and Characterization Studies of Post Translational Modification Citrullination; Mandvi Sharma ; Damagard Dres ; Anne Christian-Bay Jensen ; Claus Nielsen 4 ; Birte Svensson 5 ; Per Hagglund 6 ; PhD, Department of Systems Biology, Denmark Technical University, Copenhagen, Denmark; Institute for Inflammation Research, Department of Infectious Diseases and Rheumatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Principal Scientist, Head of Rheumatology, Nordic Biosciences, Copenhagen, Denmark; 4 Professor, Consultant Physician, Head of Department of Rheumatology, Rigshospitalet, Copenhagen, Denmark; 5 Professor Enzyme and Protein Chemistry Department of Systems Biology The Technical University of Denmark, Copenhagen, Denmark; 6 Associate Professor, Deaprtment of Systems Biology, Technical University of Denmark., Copenhagen, Denmark Characterization of Non-Heme Iron Enzymes Using Mass Spectrometry; Yi Pu ; Cheng-Hsuan Wu ; Deborah R. Leon ; Pinghua Liu ; Catherine E. Costello ; Boston University, Boston, MA Evolutionary Conservation of Sirtuin Lipoamidase Activity from Bacteria to Human Mitochondria; Elizabeth A Rowland ; Todd M Greco ; Caroline K Snowden ; Ileana M. Cristea ; Princeton University, Princeton, NJ Detecting Changes in the Epimerization of Water- Soluble and Water-Insoluble Crystallin Proteins Using Tandem LC-MS; Yana Lyon;, Riverside, CA Measurement of the Dynamics of Histone Methylation by One-Carbon Metabolic Isotope Labeling and HCD Methylation-Signature-Ions Detection; Hui Tang ; KANGLING ZHANG ; University of Texas Medical Branch at Galveston, Galveston, TX Proteomics: Clinical Applications (Applied Proteomics) MP 597 Effects of MK-80 and Clozapine on the Proteome of Cultured Human Oligodendrocytes; Juliana Silva Cassoli ; Keiko Iwata ; Johann Steiner ; Paul C. Guest ; Juliana Minardi Nascimento ; Daniel Martinsde-Souza ; Laboratoy of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil; University of Fukui, Fukui, Japan; Department of Psychiatry, University of Magdeburg,, Magdeburg, Germany MP 598 Proteomics of Benign and Metastatic Triple Negative Breast Cancer Cells and Cybrids; Vadiraja B Bhat ; Durairaj Renu ; Akanksha Mishra ; Pramila Tata ; Jun Hyoung Park ; Santhosh Kumar ; Sajna A Vithayathil ; Nagireddy Putluri ; Efrosini Tsouko ; Taraka R Donti ; Daniel E Frigo ; Chad J Creighton ; Michael T. Lewis ; Arun Sreekumar ; Lee-Jun Wong ; Benny A Kaipparettu ; Agilent Technologies, Wilmington, DE; Strand Life Sciences, Bangalore, India; Baylor College of Medicine, Houston, TX MP 599 MP 600 MP 60 MP 60 MP 60 MP 604 MP 605 MP 606 MP 607 MP 608 MP 609 Targeted Proteomic Analysis of FFPE Bone Metastases from Lung Cancer and Other Malignancies; Chao Gong ; Fabiola Cecchi ; Adele Blackler ; Wei-Li Liao ; Marlene Darfler ; Todd Hembrough ; NantOmics, Rockville, MD Comprehensive Proteome Characterization of Pancreatic Cyst Fluid from Intraductal Papillary Mucinous Neoplasm (IPMN) by LC-MS/MS; Joonho Park ; Dohyun Han ; Misol Do ; Mee Joo Kang 4 ; Jin- Young Jang 4 ; Youngsoo Kim ; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea; Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Korea; 4 Department of Surgery, Seoul National University College of Medicine, Seoul, Korea Epitope Identification of Human α-galactosidase A to a Monoclonal Antibody by Affinity Mass Spectrometry; Zdenek Kukacka, ; Marius Iurascu, ; Yannick Baschung, ; Mary Murphy 4 ; Jeff Bornheim 4 ; Michael Przybylski, ; Steinbeis Centre Biopolymer Analysis and Biomedica, Ruesselsheim, Germany; University of Konstanz, Konstanz, Germany; University of Rostock, Rostock, Germany; 4 Ametek-Reichert Technologies, Buffalo, NY Proteomics Identifies Three New Types of Amyloidosis Associated with Distinctive Clinical Phenotypes; Surendra Dasari ; Jason D Theis ; Julie A Vrana ; Samih H Nasr ; Sanjeev Sethi ; Paul J Kurtin ; Mayo Clinic, Rochester, MN Minimal Residual Disease in Multiple Myeloma by LC- MS/MS by Analysis of Immunoglobulin Heavy and Light Chain CDR Tryptic Peptides; Linda M Benson ; Angela Dispenzieri ; David L. Murray ; H. Robert Bergen, III ; Mayo Clinic, Rochester, MN; Mayo Clinic, Rochester, MN Pharmacoproteomics Identifies the Drug Efficacy Mechanism in Acamprosate Treatment of Alcoholism; Caroline M Germany ; Ashlie N Reker ; Hyung W Nam ; LSU Health Science Center, Shreveport, LA A Network Based Approach to Understand the Brain Proteome in Alzheimer s Disease; Nicholas Seyfried ; Eric B Dammer ; Vivek Swarup ; Duc Duong ; Luming Yin ; Juan C Troncoso ; Madhav Thambisetty 4 ; Daniel Geschwind ; James Lah ; Allan Levey ; Emory University School of Medicine, Atlanta, GA; UCLA, Los Angeles, CA; Johns Hopkins University School of Medicine, Baltimore, MD; 4 National Institutes of Health, Bethesda, MD To Pool or Not to Pool: Discovery of Biomarkers for Sjögren s Syndrome Using Mass Spectrometry-Based Proteomics; Wanlu Qu ; Driss Zoukhri ; Athena Papas ; Markus Hardt ; The Forsyth Institute, Cambridge, MA; Tufts University, Medford, MA Analysis of Monoclonal Immunoglobulins from Multiple Myeloma Patients by Use of Tesla FT-ICR MS/MS; Lidong He ; Lissa Anderson ; David R Barnidge ; David L Murray ; Christopher L Hendrickson ; Alan G Marshall, ; Florida State University, Tallahassee, Florida; National High Magnetic Field Laboratory, Tallahassee, FL; Mayo Clinic / DLMP, Rochester, MN Understanding the Molecular Mechanisms Underlying Cisplatin Resistance in Ovarian Cancer Cells; Yi Huo ; Yuling Chen ; Chongdong Liu ; Zhenyu Zhang ; HAITENG DENG 4 ; MOE Key Laboratory of Bioinformatics, Tsinghua University, Beijing, China,00084, Beijing, China; Tsinghua University, Beijing, China; Chaoyang Hospital Affiliated to Capital Medical University, Beijing, China; 4 Tsinghua University, Beijing Apolipoprotein Kinetics Measured in Human HDL by HR/AM-PRM Unveils a Novel Picture of HDL Metabolism; Lang Ho Lee ; Allison B Andraski ; Brett Pieper ; Frank M Sacks ; Masanori Aikawa ; Sasha A Singh ; Center for Interdisciplinary Cardiovascular Science, PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

87 MONDAY POSTERS MP 60 MP 6 MP 6 MP 6 MP 64 MP 65 MP 66 MP 67 MP 68 MP 69 MP 60 Brigham and Women s Hospital and Harvard Medical School, Boston, MA; Department of Nutrition, T.H. Chan Public Health School of Harvard University, Boston, MA Relevance of Albumin Bound Iron in Ovarian Cancer as Determined by ICP-MS; Lindsay Schambeau ; Lauren Amable ; Jana Rocker ; Michael Finan ; Rodney Rocconi ; Lewis Pannell ; Mitchell Cancer Institute, Mobile, AL; National Institutes of Health, Bethesda, MD Proteomic Analysis of an ALDH Sub-Population in Colorectal Cancer Identified by Liquid Chromatography- Mass Spectrometry; Rui Yang ; Xinhua Liu ; Smathorn Thakolwiboon ; Jianhui Zhu ; Xiucong Pei ; Zhijing Tan ; Mingrui An ; Jun Cao ; Jing Wu ; David M Lubman ; University of Michigan Medical Center, Ann Arbor, MI; Shanghai University, Shanghai, CHINA; Mahidol University, Bangkok, Thailand Ion Current-based Proteomic Profiling in Understanding the Mechanism of Tumor Necrosis Factor Alpha on Myogenic Differentiation; Chengjian Tu ; Jun Li ; Jun Qu ; University at Buffalo, Buffalo, NY; University at Buffalo SUNY, Williamsville, NY Characterization of O- and N-Glycosylations of Immunoglobulin A in IgA Nephropathy; Jean-Marie Schmitter ; Katell Bathany ; Christelle Oblet ; Jean-Claude Aldigier ; Anne Druilhe ; University of Bordeaux, Bordeaux, France; University of Bordeaux, Bordeaux, France; University of Limoges, Limoges, France Effect of Radiotherapy on Protein Levels in Blood Plasma Collected from Breast Cancer Patients; Catherine C Going ; Marta Vilalta ; Marjan Rafat ; Melissa Jenkins ; Kathleen C Horst ; Edward E Graves ; Sharon J Pitteri ; Stanford University School of Medicine, Palo Alto, CA Prions in Hormonal Replacement Therapy?; Tanja Panic- Jankovic ; Maria Zellner ; Goran Mitulovic ; Medizinische Universitaet Wien, Vienna, Austria; Medical University of Vienna, Vienna, Austria Mass Spectrometry Based Proteomic Investigation of Annulus Fibrosus and Nucleus Pulposus of the Mature Bovine Intervertebral Disc; Willem Duckworth ; Ashley Brisbin ; Kelly L Wormwood ; Emmalyn J Dupree ; Jessica Roberge ; Devika Channaveerappa ; Petra Kraus ; Thomas Lufkin ; Costel C Darie ; Clarkson University, Potsdam, NY Single Amino Acid Variation Profiles of the MCF7 Breast Cancer Cell Line Using LC-MS/MS; Zhijing Tan ; Song Nie, ; Mingrui An ; Rui Yang ; Jun Cao ; Xiucong Pei ; David M. Lubman ; The University of Michigan, Ann Arbor, MI; Pacific Northwest National Laboratory, Richland, WA Evaluation of Undifferentiated State of Human ips Cells by Non-Invasive LC-MS/MS Analysis Approach Using Cell Culture Supernatant as Samples; Takashi Suzuki ; Gamo Kentaro ; Hatabayashi Kunitada ; Takahashi Masatoshi ; Kagawa Kenichi ; Ogura Tairo ; Hiramaru Daisuke ; Toyoda Kenichi ; Ozaki Shigenori ; Shimadzu Corporation, Kyoto, Japan; Tokyo Electron Limited, Kobe, Japan; Shimadzu Scientific Instruments, Inc. Columbia Quantitative Proteomics Analysis Reveals Molecular Signatures Associate with LPS, Betamethasone, and Magnesium Sulfate Treatment in E5 Murine Gastrointestinal Tract; Elizabeth Yohannes ; Jesica L. Slack ; Vivek Ramachandran ; Andrew S. Thagard ; Mark Wingerd ; Avedis Kazanjian ; Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington; Maternal Fetal Medicine, Madigan Army Medical Center, Tacoma, Washington Proteomics of Globo H High/Low BxPC- Pancreatic Cancer Cell Line; Sheng-Ta Tsai ; Hsin-Ying Han ; Shok- Li Ng ; Chia-Ning Shen ; Chung-Hsuan Chen ; Genomics Research Center, Academia Sinica Taipei, Taiwan MP 6 MP 6 MP 6 MP 64 MP 65 MP 66 MP 67 MP 68 MP 69 MP 60 MP 6 Proteomic Analysis by SILAC to Distinguish between Salmonella Lipopolysaccharide (LPS) and Monosodium Urate (MSU) Crystals Induced Inflammation in Macrophages; Sarbjeet Makkar ; Rohana Liyanage ; Jr Jackson O Lay ; University of Arkansas, Fayetteville, AR Proteomics: Quantitative Quantitation of Immunoglobulin Alpha from Whole Gut Lavage Fluid Using the Thermo Q-Exactive Plus; Joseph Otto ; Crystal Daniels ; Lindsay Schambeau ; Jana Rocker ; Mitchell Cancer Institute, Mobile, AL Targeted Quantitation of CrbpI in Cancer Cells through a Bottom-Up Approach; Wenjing Li ; Jianshi Yu ; Claire Louise Carter ; Jace W Jones ; Maureen A Kane ; University of Maryland School of Pharmacy, Baltimore, MD Kinase Activity Profiling of Lung Adenocarcinoma to Understand Cancer Signaling and Select Targeted Therapeutics; Melissa A. Hoffman, ; Bin Fang ; Stephen Brantley ; Fumi Kinose ; Eric Welsh ; Steven A. Eschrich ; Eric B. Haura ; John M. Koomen ; Moffitt Cancer Center, Tampa, FL; University of South Florida, Tampa, FL Label-Free Quantitative Proteomics Profiling of Human Osteoclast Activation, Differentiation and anti-tnf Biologics Treatment; Chenqi Hu ; Bohdan Harvey ; Zehra Kaymakcalan ; Edit Tarcsa ; Dongdong Wang ; Yu Tian ; Abbvie Bioresearch Center, Worcester, MA Protein Biomarker Quantitation from Human Blood and Plasma Using Novel Collection Technology by LCMS/ MS; Alan Barnes ; Neil Loftus ; Jérôme Vialaret ; Christophe Hirtz ; Sylvain Lehmann ; Shimadzu MS/BU, Manchester, Greater Manchester; Shimadzu, Manchester, UK; CHU de Montpellier, Montpellier, France In Depth Quantification of Extracellular Matrix Proteins from Human Pancreas for Tissue Engineering; Fengfei Ma ; Christopher Lietz ; Sara Sackett ; Dan Tremmel ; Jon Odorico ; Lingjun Li, ; School of Pharmacy, University of Wisconsin-Madison, Madison, WI; Department of Chemistry, University of Wisconsin-Madison, Madison, WI; Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison,, Madison, WI Identification of Interaction Networks of Mutant and Wild-Type IDH in Glioma Cell Lines; Nina Overbeck ; Anja Stefanski ; Vanessa Scherbaum ; Christiane Knobbe- Thomsen ; Kai Stühler ; Molecular Proteomics Laboratory, Heinrich-Heine-University, Düsseldorf, Germany; Department of Neuropathology, Heinrich-Heine-University, Düsseldorf, Germany Quantitative MRM Assays of Salivary Proteins for Biomarker Assessment Studies; Andrew J Percy ; Darryl B Hardie ; Juncong Yang ; Armando Jardim ; Yassene Mohammed, ; Monica H. Elliott ; Christoph H. Borchers 4, 5 ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; Institute of Parasitology, McGill University, Montreal, QC, Canada; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands; 4 University of Victoria - Genome BC Proteomics Centre, Victoria, BC; 5 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada Toward the Development of a Scheduled GeLC-MRM Method for High-Throughput Quantitative Profiling of Small GTPases in Cancer Cells; Ming Huang ; Yinsheng Wang ; University of California, Riverside, Riverside, California; University of California, Riverside, Riverside, CA Targeted Proteomic Analysis Using Parallel Reaction 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 87

88 GENERAL MONDAY INFORMATION POSTERS MP 6 MP 6 MP 64 MP 65 MP 66 MP 67 Monitoring Revealed Longitudinal Change in Level of Proteins in Activation of BV Mouse Microglia; Woo Jongmin ; Han Dohyun, ; Kim Youngsoo ; Department of Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea; Department of Biomedical Engineering, Seoul National University, College of Medicine, Seoul, Korea; Biomedical Research Institute, SNUH, Seoul, Korea Changes in Lipid Raft Proteome upon TNF-α Stimulation of Cystic Fibrosis Cells Using SILAC; Cerina Chhuon ; Iwona Pranke ; Florence Borot ; Danielle Tondelier ; Joanna Lipecka ; Janine Fritsch ; Marc Chanson 4 ; Aleksander Edelman ; Mario Ollero 5 ; Chiara Ida Guerrera ; Proteomic Platform Necker, PPN-P5, Structure Fédérative de Recherche SFR Necker US4, 7505, Paris, France; Institut Necker Enfants Malades, INSERM, U5, Paris, France; The CPN Proteomics Facility P5, Center of Psychiatry and Neuroscience, UMR INSERM 894, 7504, Paris, France; 4 Geneva University Hospitals and University of Geneva,, Geneva, Switzerland; 5 Institut Mondor de Recherche Biomédicale, INSERM, U955, and Université Paris Est Créteil, 9400, Créteil, France MRM Quantitation of an In-depth Panel of Candidate Disease-linked Proteins in Various Mouse Tissues; Sarah Michaud ; Andrew Percy ; Nicholas Sinclair ; André LeBlanc ; Suping Zhang ; Christoph H. Borchers, 4 ; MRM Proteomics Inc, Victoria, BC, Canada; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; MRM Proteomics, Inc., Victoria, BC, Canada; 4 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada The Proteomic Landscape of Breast Patient-Derived Xenografts Reveals Tumor-Specific Education of the Cancer Microenvironment; Xuya Wang ; Petra Erdmann- Gilmore ; Rosa Viner ; Matthew R Meyer ; Timothy J Stuhlmiller 4 ; Sherri R Davies ; Shunqiang Li ; Qiang Zhang ; Arshag D Mooradian ; Kuan-lin Huang 5 ; Ryan Bomgarden 6 ; Li Ding 5 ; Matthew J Ellis 7 ; John C Rogers 6 ; Gary L Johnson 4 ; Reid R Townsend ; David Fenyö ; Jason M Held, 8 ; NYU School of Medicine, New York City, NY; Washington University School of Medicine, Saint Louis, MO; Thermo Fisher Scientific, San Jose, CA; 4 Department of Pharmacology University of North Carolina, Chapel Hill, NC; 5 The Genome Institute Washington University, Saint Louis, MO; 6 Thermo Fisher Scientific, Rockford, IL; 7 Baylor College of Medicine, Houston, TX; 8 Department of Anesthesiology Washington University, Saint Louis, MO The Pathway Activity of Fatty Acid β-oxidation is Up- Regulated in the Skeletal Muscle Mitochondria of TDM Mouse Model; Zhou Yang, ; Hou Guixue, ; Wu Lin ; Lou Xiaomin ; Ren Yan ; Su Siyuan, ; Deng Yamei, ; Li Qidan, ; Zhang Yue, ; Zi Jin ; Liu Siqi, ; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academic of Sciences, Beijing, China; BIG-Shenzhen, Shenzhen, China; BGI shenzhen, Shenzhen, China In-Depth Quantitative Proteomic Analysis of Human Breast Cancer Cells in Response to Nicotinamide; Dohyun Han, ; Ji Young Kim ; Joonho Park ; Han Suk Ryu ; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea; Department of Biomedical Engineering, Seoul National University Hospital, Seoul, Korea; Department of Pathology, Seoul National University Hospital, Seoul, Korea itraq Based Quantitative Proteomics of a Brain- Enriched Cytosolic Protein Fraction in Schizophrenia; Erika Velásquez ; Daniel Martins-de-Souza ; Ingrid Velásquez ; Andrea Schmitt 4 ; Fabio Cs Nogueira 5 ; Gilberto B Domont ; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Unicamp, Campinas, SP; University MP 68 MP 69 MP 640 MP 64 MP 64 MP 64 MP 644 MP 645 MP 646 of Carabobo, Valencia, Venezuela; 4 Ludwig Maximilian University of Munich, Munich, Germany; 5 UFRJ, Rio de Janeiro, Rio de Janeiro Challenges of Using Isobaric Labeling for In-Depth Analysis of Large Numbers of Plasma Samples in a Cardiotoxicity Biomarker Discovery Study; Pengyuan Liu ; Lynn A. Beer ; Bonnie Ky ; David W Speicher ; The Wistar Institute, Philaldephia, PA; University of Pennsylvania, Philadelphia, PA Quantitative Multiplexed Isobaric Tag-Based Proteomic and Phosphoproteomic Profiling Reveals Nicotine and Cigarette Smoke Extract-Induced Alterations in Human Pancreatic Stellate Cells; Joao A Paulo ; Steven P Gygi ; Harvard, Boston, MA; Harvard Medical School, Boston, MA SILAC-based Phosphoproteomic Analysis of PTHR Signaling in Proliferating Osteoblasts; Lauren E Ball ; Grace Williams ; Jennifer Bethard ; Louis Luttrell ; Medical Univ of S Carolina, Charleston, SC Quantitative Temporal Proteomics of Flow Cytometry Isolated Virus-Driven MDSCs; Derek Clements ; Patrick Murphy ; Youra Kim ; Andra Sterea ; Shekoufeh Almasi ; Namit Holay ; Prathyusha Konda ; Joao Paulo 4 ; Steven P Gygi 4 ; Shashi Gujar ; Patrick Lee, ; Department of Pathology, Dalhousie University, Halifax, NS, Canada; Department of Microbiology & Immunology, Dalhousie University, Halifax, NS, Canada; Department of Biology, Dalhousie University, Halifax, NS, Canada; 4 Harvard University, Boston Down Regulation of Glycolysis Pathway in PICALM Depleted Cells; Barsam Mirfattah ; Hui Tang ; Cheryl F Lichti ; Fernanda Laezza ; Kangling Zhang ; University of Texas Medical Branch at Galveston, Galveston, TX Phosphoproteomic and Glycoproteomic Studies of Tonic and Activated B Cell Receptor Signaling in Burkitt s Lymphoma; Jasmin Corso ; Kuan-Ting Pan ; Roland Walter ; Carmen Döbele ; Sebastian Mohr ; Christof Lenz, ; Hubert Serve, 4 ; Henning Urlaub, ; Thomas Oellerich, 4, 5 ; Bioanal. MS Group, Max Plank Inst for Biophys Chem, Goettingen, Germany; Department of Hematology/Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany; Bioanalytics, University Medical Center Göttingen, Institute for Clinical Chemistry, Goettingen, Germany; 4 German Cancer Consortium/ German Cancer Research Center, Heidelberg, Germany; 5 Department of Haematology, University of Cambridge, Cambridge, United Kingdom Quantitative Profiling of Peroxisome Proliferation in the Heart by Selected Reaction and Selected Ion Monitoring. Effects of High Fat Diets; Caroline Kinter ; Maria Thomas ; David Gutierrez ; Szweda Luke ; Michael Kinter ; Oklahoma Medical Research Foundation, Oklahoma City, OK MS-Based Quantitative Proteomics Investigation of Mechanisms Underlying Gemcitabine and Trabectedin Synergism with High Multiplexing Capacity and Extremely Low Missing Value; Shichen Shen ; Xin Miao ; Jun Li ; Xiaomeng Shen ; Xue Wang ; William Jusko ; Jun Qu ; University at Buffalo, Buffalo, NY Understanding Proteomic Alterations in GBM Tumors Associated with the Subventricular Zone: a Quest for Better Prognosis; Ghantasala Saicharan ; Gollapalli Kishore ; Shailendra Rane ; Deepti Bhandarkar ; Sanjeeva Srivastava ; Aliasgar Moiyadi 4 ; Indian Insitute of Technology, Bombay, Mumbai, India; Indian Institute of Technology, Bombay, Mumbai, India; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, INDIA; 4 Tata Memorial Centre s- Advanced Centre for Research, Training and Education in Cancer, Kharghar, Navi Mumbai, India PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

89 MONDAY POSTERS MP 647 MP 648 MP 649 MP 650 Exploration of Novel Mechanisms for Synergy of Paclitaxel and Birinapant through Large-scale Quantitative Label-free LC/MS Proteomics; Xue Wang ; Jin niu ; Jun Li ; Shichen Shen ; Xiaomeng Shen ; Jun Qu ; University at Buffalo, Buffalo, NY; Center of Excellence in Bioinformatics&Life Sci., Buffalo, NY ProteOMZ: Development of Biogeochemically Relevant Peptide Biomarkers for High-Throughput Marine Microbial Ecosystem Characterization in Oceanic Oxygen Minimum Zones; Mak Saito ; Matt McIlvin ; Dawn Moran ; Alyson Santoro ; Chris Dupont ; Michael Rappe 4 ; Woods Hole Oceanographic Institution, Woods Hole, MA; University of Maryland Horn Point Laboratory, Cambridge, MD; J.C. Venter Institute, La Jolla, CA; 4 Hawaii Institute of Marine Biology, University of Hawaii, Manoa, HI Sensitive, Fast and Robust Quantification of Antibodies in Complex Matrices by Capillary Flow UHPLC and High Resolution Accurate Mass MS; Alexander Boychenko ; Stephan Meding ; Martin Samonig ; Remco Swart ; Thermo Fisher Scientific, Bremen, DE; Thermo Fisher Scientific, Germering, DE Src-Family Kinase Signaling Mediating Gemcitabine Resistance in Gall Bladder Cancer Revealed by Quantitative Phosphoproteomics; Patricia García ; Jun Zhong ; Carolina Bizama ; Jaime Espinoza ; Juan Carlos Roa ; Pamela Leal ; Department of Pathology, School of Medicine; Center for Investigation in Translational Oncology (CITO), FONDAP-ACCDIS, Pontificia Universidad Católica de Chile, Santiago, Chile; Delta Omics Biotechnology, Catonsville, MD; Center of Genetic and Immunological Studies (CEGIN) and Scientific and Technological Bioresource Nucleus (BIOREN). Universidad de La Frontera, Temuco, Chile Small Molecules: Qualitative Analysis MP 65 Identification of Chemical Ingredients from Ginkgo biloba Extract Using UHPLC-QTOF/MS Coupled with PCDL Library; Guoqiang Liu ; Shan-An Chan ; Agilent Technology, Inc. Shanghai, China; Agilent Technology, Inc. Taipei Taiwan, Taiwan MP 65 Collision-Induced Dissociation MS/MS of Cimitrypazepines, A New Class of Alkaloids from Black Cohosh (Actaea racemosa); Dejan Nikolic ; David C Lankin ; Richard van Breemen ; University of Illinois College of Pharmacy, Chicago, IL MP 65 Dereplication of Fungal Secondary Metabolites by UPLC-PDA-HRMS-MS/MS and Mass Defect Filtering; Noemi Paguigan ; Tamam M. El-Elimat, ; Diana Kao, ; Huzefa A. Raja ; Cedric J. Pearce ; Nicholas H Oberlies ; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC; Chemistry and Biochemistry Department, Greensboro, NC; Mycosynthetix, Inc., Hillsborough, NC MP 654 Development and Evaluation of a Dual Separation, High-Resolution, nano-esi-lc-ms/ms Approach for Dissolved Soil Organic Matter Characterization; Mallory P Ladd, ; Robert Hettich ; Oak Ridge National Laboratory, Oak Ridge, TN; University of Tennessee-Knoxville, Knoxville, TN MP 655 Formation of m/z 9 Ion During Fragmentation of Deprotonated N-butyl Benzenesulfonamide; Chongming Liu ; Athula B. Attygalle ; Stevens Institute of Technology, Hoboken, NJ MP 656 Gas-phase Methylation of Benzene by an Internal Electrophilic Aromatic Addition Mechanism Mediated by in-situ Generated Methylcarbenium Ion; Hanxue Xia ; Athula Attygalle ; Yong Zhang ; SIT, jersey city, New Jersey; Stevens Institute of Technology, Hoboken, NJ MP 657 MP 658 MP 659 MP 660 MP 66 Non-Targeted Screening of Tattoo Ink Contaminants Using Liquid Chromatography/ High-Resolution Mass Spectrometry and Chemometrics; Caitlin N. Kneapler ; Ann M. Knolhoff ; Clark Ridge ; Fred Fry ; Timothy R Croley ; FDA/CFSAN, College Park, MD Applications of Infrared Ion Spectroscopy in Bioanalytical Chemistry; Jonathan Martens ; Giel Berden ; Jos Oomens ; FELIX Laboratory - IMM - Radboud University, Nijmegen, The Netherlands A Bayesian Prior Probability Model to Improve the Confidence of Chemical Identification; Tyler A Zimmerman ; W.Gary Mallard ; Tytus D Mak ; Nirina Rabe Andriamaharavo ; Dmitrii V Tchekhovskoi ; Stephen E Stein ; National Institute of Standards and Technology, Gaithersburg, MD; National Institute of Standards & Technology, Rockville, MD Investigation of the Metabolites of the HIF-Stabilizer FG-459, Formed by Four in vitro Models, Using High Resolution Mass Spectrometry; Annelie Hansson ; Mario Thevis ; Geoff Miller ; Daniel Eichner ; Ulf Bondesson, 4 ; Mikael Hedeland, 4 ; Uppsala University, Uppsala, SE; German Sport University, Cologne, DE; Sports Medicine Research and Testing Laboratory, Salt Lake City, UT; 4 National Veterinary Institute, Uppsala, SE The ETD-Like Fragmentation for Small Molecules; Romain Huguet ; Chad R Weisbrod ; Mark Berhow ; Vlad Zabrouskov ; Jae Schwartz ; Tim J Stratton ; Thermo Fisher Scientific, San Jose, CA; USDA, ARS NCAUR Peoria, IL MP 66 Application of TOF MS instrument in Bioanalysis A Case Study; Shaokun Pang ; Weixing Sun ; Adrien Musuku ; Xavier Misonne ; SCIEX, Redwood City, CA; Pharmascience, Montreal, Canada; SCIEX, Lorraine, QC MP 66 MP 664 MP 665 MP 666 MP 667 MP 668 MP 669 On-Line Chiral Analysis of Reaction Mixtures Using the Kinetic Method; Ryan M Bain ; Xin Yan ; Shannon A Raab ; Stephen T Ayrton ; Tawnya G Flick ; Graham R Cooks ; Purdue University, West Lafayette, IN; Amgen, Inc., Thousand Oaks, CA Automated Correlation between Structural Isomers and Fragment Ion Spectra Using a Novel Fragmentation Prediction Engine ; Kirsten Hobby ; Richard T Gallagher ; Shimadzu MS/BU, Manchester, Lancashire; AstraZeneca, Maccelsfield, UK Effects of Low Percentage Non-Ionic Additives on Charge State and Ion Intensity in Electrospray Ionization for Small Molecule Analysis; Jeffrey Alberts ; Kenneth J Ruterbories ; David W Bedwell ; Kishore K Katyayan ; Kenneth C Cassidy ; Eli Lilly and Company, Indianapolis, IN Understanding Paper Degradation: Identification of Products of Cellulosic Paper Decomposition at the Wet- Dry Tideline Interface Using GC-MS and LTQ Orbitrap; Sergey Sladkevich ; Anne-Laurence Dupont ; Michel Sablier ; Richard B. Cole ; Sorbonne Universités, UPMC Univ Paris 06, Paris, France; Muséum National d Histoire Naturelle, Paris, France Development of a GC-MS Method for Structure Elucidation of Disubstituted Naphthalenes; Kirill Tretyakov ; Stephen Stein ; Anzor Mikaia ; National Institute of Standards and Technology, Gaithersburg, MD Substituting Atmospheric Solid Analysis Probe Ionization for Direct Probe Electron Impact Ionization for Analysis of Alcohols and Hydrocarbons; Martha M. Vestling ; Trevor C. Christenson; Stephanie N. Knezz; University of Wisconsin, Madison, WI Dosing Syringe Extractables Analysis Using Bench-top Orbitrap Mass Spectrometer; Kenneth Wong ; Dujuan Lu ; Kate Comstock ; SGS, Fairfield, NJ; Thermo Fisher Scientific, San Jose, CA 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 89

90 GENERAL MONDAY INFORMATION POSTERS MP 670 Identification and Quantitation of IV Bag Extractables Using LC-HRMS and GCMS ; Dujuan Lu ; Kenneth Wong ; Kate Comstock ; SGS, Fairfield, NJ; Thermo Fisher Scientific, San Jose, CA MP 67 Impurity Profiling of Pharmaceuticals Using a UPLC- ToF Data Independent Acquisition Strategy and Scientific Data and Library Information Systems; Jayne Kirk ; Russell Mortishire-Smith ; Sean McCarthy ; Mark Wrona ; Waters Corporation, Wilmslow, UK; Waters Corporation, Milford, MA MP 67 The Application of Electrochemistry/MS to Pharmaceutical Stability Testing and Degradant Synthesis; Martin Eysberg ; Jean-Pierre Chervet ; Nico Reinhoud ; Mark Taylor ; Susana da Silva Torres ; Antec LLC, Boston, MA; Antec, Zoeterwoude, The Netherland; Pfizer Worldwide Research and Development, Kent, United Kingdom MP 67 Differentiating between Leachates and Process Related Compounds in Drug Substance Using Accurate Mass LC-MS and LC-MS/MS; George L Perkins ; Lorraine Hill ; Gary Campbell ; Matthew Balmer ; Sanofi Pasteur Inc, Swiftwater, PA MP 674 Analysis of Celastrol in Rat Brain Tissue and Plasma Samples Using TSQ Quantum Access MAX; Usha Mishra; Minnmass(Minnesota Mass Spec), Minneapolis, MN MP 675 Determination of Limaprost, an Analogue of PGE in Human Plasma by QTRAP and SelexION + Technology; Gangyi Liu ; Chao Zhang ; Wenhai Jin ; Xuhui Center Hospital, Shanghai, China; SCIEX Asia Pacific Application Support Center, Beijing, China; SCIEX Asia Pacific Application Support Center, Shanghai, China MP 676 Effects of Temperature and Anticoagulant on the Stability of Tetracyclines in Whole Blood: Drug-Matrix Equilibrium; Vinicio Vasquez ; Richard Lavallée ; Nikolay I Youhnovski ; Milton Furtado ; Anahita Keyhani ; Algorithme Pharma Inc., Laval, Canada MP 677 Extremely Low LC-MS/MS Lithium Adduct Detection of Rapamycin in Animal Blood and Tissues; Alexandre Pimenov ; Timothy Samuels ; Charles River Bioanalisys, Senneville, Canada MP 678 Analyzing Zn-BDPA Probes to Detect Apoptotic Cells in Three-Dimensional Cell Culture System via Mass Spectrometry; Jessica K Lukowski ; Eric M Weaver ; Kasey Clear ; Bradley D Smith ; Amanda B Hummon ; University of Notre Dame, Notre Dame, Indiana MP 679 LC-MS Based Approach to Characterize Non-Specific Binding Inhibitors to Mycobacterium tuberculosis Shikimate Kinase (MtSK); Mansour Alturki ; Madison Jarrard ; Rene Ngouli ; Douglas Goodwin ; Angela Calderon ; Auburn University, Auburn, AL MP 680 Synthesis and Characterization of Tetraphenylporphyrinate Manganese(III) Siloxides by Silyl Group Transfer from Silanethiols; Zachary J Tonzetich ; Daniel J Meininger ; Zieph Kasrawi ; Hadi D Arman ; Wendell P. Griffith ; University of Texas at San Antonio, San Antonio, TX Systems Biology (Multiomics and Other) MP 68 Trans-omics Analysis of Yeast Central Carbon Metabolism by Integration of Metabolome, Proteome and Fluxome Data; Fumio Matsuda ; Syunsuke Nishino ; Tairo Ogura ; Atsumi Tomita ; Ichiro Hirano ; Hiroshi Shimizu ; Osaka Univeristy, Osaka, Japan; Osaka University, Osaka, Japan; Shimadzu Corporation, Kyoto, Japan MP 68 Proteomics and Metabolomics Demonstrate Inheritance of Key Energy Pathways in Red Blood Cells; Erin M. Weisenhorn ; Thomas J. van t Erve ; Michael S Westphall ; Thomas J. Raife 4 ; Joshua J Coon 5 ; Integrated Program in MP 68 MP 684 MP 685 MP 686 MP 687 MP 688 MP 689 MP 690 MP 69 Biochemistry, University of Wisconsin-Madison, Madison, Wi; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC; University of Wisconsin- Madison Genome Center of Wisconsin, University of Wisconsin, Madison, Madison, WI; 4 Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI; 5 Departments of Chemistry and Biomolecular Chemistry, University of Wisconsin Madison, Madison, WI Proteomic and Metabolomic Comparative Analyses of Plasma and Vasculature Tissue from TiOnanoparticle Exposed Rats; Megan M. Maurer ; Jinghai Yi ; Carroll McBride ; Timothy R. Nurkiewicz ; Stephen J Valentine ; West Virginia University, Morgantown, WV Combined Metabolomics-Proteomic Profiling Reveals Intermittent Hypoxia to Result in Lower Productivity on Scale-Up to a 5000-Liter Industrial CHO Bioprocess; Yuanwei Gao ; Somak Ray ; Shujia Dai ; Alexander R. Ivanov ; Nicholas R. Abu-Absi ; Amanda M. Lewis ; Zhuangrong Huang ; Xing Zizhou ; Michael C. Borys ; Zheng Jian Li ; Barry L Karger ; Northeastern University, Boston, Massachusetts; Bristol-Myers Squibb, Devens, MA Triomics Analysis from Cancer Cells and Tumors: Modeling the Biology of Disease through The Integration of Metabolomics, Lipidomics and Phosphoproteomics; Susanne Breitkopf ; Min Yuan ; Ying Xu ; John M Asara, ; Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston, MA Integrated Multi-Omic Analysis of Chinese Hamster Ovary Cells; Joseph Longworth ; Javier Gonzalez ; Paul Dobson ; Josselin Noirel ; Neil Lawrence ; Mark Dickman ; David James ; The University of Sheffield, Sheffield, United Kingdom; The University of Manchester, Manchester, United Kingdom; Conservatoire National des Arts et Métiers, Paris, France Systematic Integration of Multiple Omics Data for Yeast Strains Isolated from Different Environments; Rohith Srivas ; Barbara Dunn ; Andreas Huhmer ; Daniel Lopez Ferrer ; Michael Snyder ; Dept. of Genetics, Stanford University, Palo Alto, CA - California; Thermo Fisher Scientific, San Jose, CA; ThermoFisher, Palo Alto, CA Integrative Analysis of Proteome, Transcriptome, and MHC Class I Ligandome of Human Cancer Cell Lines; Pedro Navarro ; Sebastian Boegel ; Jennifer Hahlbrock ; John C Castle ; Meike Wagner ; Hansjörg Schild ; Ugur Sahin ; Stefan Tenzer ; Institute for Immunology, JG University Medical Center, Mainz, Germany; TRON Translational Oncology at the University Medical Center of Johannes Gutenberg University, Mainz, Germany; Agenus, 4-Antibody AG, Basel, Switzerland Differential Dynamics of the Mammalian mrna and Protein Expression Response to Misfolding Stress; Zhe Cheng ; Guoshou Teo ; Sabrina Krueger ; Tara Rock ; Hiromi Koh ; Hyungwon Choi ; Christine Vogel ; New York University, New York, NY; National University of Singapore, Singapore, Singapore; Max-Delbruck-Center, Berlin, Germany High Resolution Mass Spectrometry-Based Subcellular Proteomics of a Human Cell Line; Aikaterini Geladaki ; Claire Mulvey ; Jake Beech ; Kathryn S Lilley ; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom A Multi-Molecular Omics Approach to Study Metabolic Shifts in Caveolin- Transgenic Mice; Cristina Coman ; Denisa Gabriela Hathazi ; Andreas Roos ; Robert Ahrends ; Leibniz-Institut für Analyt. Wissensch. - ISAS -, Dortmund, Germany PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

91 MONDAY POSTERS MP 69 MP 69 MP 694 MP 695 MP 696 MP 697 MP 698 MP 699 MP 700 MP 70 Integration of Metabolomic and Proteomic Profiles with Physiological Measures to Understand the Complex Mechanisms of Sodium Fluoroacetate Toxicity; Nadja Grobe, ; Meghan K Makley, ; Mitchell L Meade ; Andrea Hoffmann, ; Jeffery M Gearhart, ; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF), Wright-Patterson AFB, OH; Molecular Bioeffects Branch, Bioeffects Division, Human Effectiveness Directorate, 7th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson AFB, OH; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF), Wright-Patterson AFB, OH In-Depth Secretome Analysis of Ovarian Clear Cell Carcinoma with ARIDA Knockdown and EZH Inhibition.; Aaron R Goldman ; Benjamin G Bitler ; Rugang Zhang ; David W Speicher ; The Wistar Institute, Philaldephia, PA Data-independent Mass Spectrometry: An Effective Tool in Mechanistic Neurotoxicological Research; Pallavi P Pilaka ; Pretal P Muldoon ; Pavel N Lizhnyak ; Andrew K Ottens ; Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA Data-Driven Construction of Global Drug Mechanisms Enabled by an Integrated High-Throughput Multi- Omics Platform; Jeremy L Norris ; Melissa A Farrow ; Danielle Gutierrez ; Nicole Muszynski ; Lauren D Palmer ; Stacy D Sherrod ; James C Pino ; Jamie L Allen ; Jeffrey M Spraggins ; Alex Lubbock ; Ashley T Jordan ; William J Burns ; James C Poland ; Carrie E Romer ; Nathaniel Braman ; Yuan-wei Nei ; Kristie L Rose ; Salisha Hill ; Lisa M Manier ; Tina Tsui ; M. Ray Keller ; Stacey A Rutherford ; Nichole A Lobdell ; Carlos Lopez ; D. Borden Lacy ; John A McLean ; John P Wikswo ; Eric P Skaar ; Richard M Caprioli ; Vanderbilt University, Nashville, TN Applying Sequence Clustering to Facilitate Sample Comparisons in Metaproteomes Searched Against Different Metagenomes in Human Microbiome Research; Jose Alfredo Blakeley-Ruiz ; Weili Xiong ; Yang Song ; Claire Fraser-Liggett ; Robert Hettich ; University of Tennessee, Knoxville, TN; Oak Ridge National Laboratory, Oak Ridge, TN; University of Maryland Baltimore, Baltimore, USA Rapid Changes in the Proteome of Gut Microbiota in Response to Short-Term Dietary Challenges in Baboons; Prahlad K Rao ; Kimberly D Spradling-Reeves ; Vicki Mattern ; Laura Cox ; Anthony G Comuzzie ; Michael Olivier ; Texas Biomedical Research Institute, San Antonio, TX Mass Spectrometry Based Systems Biology Approaches to Understand Platelet Metabolism; Ottar Rolfsson, ; Steinn Guðmundsson, ; Manuela Magnusdottir, ; Freyr Johansson, ; Ólafur Eysteinn Sigurjónsson, 4 ; Bernard O Palsson, ; Center For Systems Biology, Reykjavik, Iceland; University of Iceland, Reykjavik, Iceland; Reykjavik University, Reykjavik, Iceland; 4 The Icelandic Blood Bank, Reykjavik, Iceland Exercise-Induced Protein Secretion from Muscle; You Zhou ; Ji Li ; Sammy Pardo ; Dana Molleur ; Caleb Emmons ; Susan T Weintraub ; Nicolas Musi ; Univ. of Texas HSC, San Antonio, TX; Proteome Software, Portland, OR Data-independent Quantitative Mass Spectrometry in Brain Injury Therapeutic Development; Pavel Lizhnyak ; Andrew K. Ottens ; Dept Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA Asymmetric Flow Field-Flow Fractionation Coupled with On-Line Trypsin Digestion and LC-MS/MS for Quantitative Analysis of Lipoprotein Sub-Class Composition; John R. Barr ; Zsuzsanna Kuklenyik ; Michael Gardner ; Bryan A Parks ; Christopher Toth ; Jeffrey MP 70 MP 70 MP 704 MP 705 MP 706 MP 707 Jones ; Michael Andrews ; David M Schieltz ; Jon Rees ; Lisa G McWilliams ; James L. Pirkle ; CDC, Atlanta, GA; Center for Disease Control and Prevention, Atlanta, GA; Battelle Memorial Institute, Atlanta, GA Analysis of Liver and Heart Spheroids in Drug-Induced Hepatotoxicity and Cardiotoxicity; Nathalie Selevsek ; Bernd Roschitzki ; Jens Kelm ; Olivia Rose Clayton ; Claudia Fortes ; Witold Wolski ; Jonas Grossmann ; Laura Kunz ; Paolo Nanni ; Adrian B. Roth ; Ralph Schlapbach ; Functional Genomics Center Zurich, University of Zurich & ETH Zurich, Zurich, Switzerland; InSphero AG, Schlieren, Switzerland; Roche Innovation Center Basel, Grenzacherstasse Basel, Switzerland Label Free Proteomics Profiling Unveils Down Regulation of Thrombin Mediated Signaling and Aggregation of Human Platelets upon Treatment with Thrombin Inhibitors; Cristina Clement ; Ebenezer L.V. Ewul ; Anna Babinska ; Janet Gonzalez 4 ; Monika Dzieciatkowska 5, 6 ; Moro Salifu 7 ; Manfred Philipp ; Albert Einstein CollegeMed, Bronx, NY; Chemistry Department Lehman College CUNY, Bronx, NY; Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY; 4 Department of Natural Sciences, LaGuardia Community College, Queens, NY; 5 Biological Mass Spectrometry Core Facility, University of Colorado at Denver, Aurora, Colorado; 6 Biological Mass Spectrometry Core Facility, University of Colorado at Denver, Aurora, Denver, CO; 7 Division of Nephrology, Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY Validation of a Unified Sample Preparation Platform for Multi-Omics Technologies; Danielle Gutierrez ; Stacy D Sherrod ; Jeremy L Norris ; Carrie E Romer ; Melissa A Farrow ; Simona Codreanu ; Randi Lee Gant-Branum ; Yuan-wei Nei ; John A McLean ; Richard M Caprioli ; Vanderbilt University, Nashville, TN ChIP-MS/TMT: A Quantative Proteomic Analysis of Steroid Hormone Receptor Activation; Andrew Holding;, Cambridge, Cambridgeshire Proteomewide Profiling of Geranylgeranyl Pyrophosphate-Protein Interaction Network in Liver via Click Chemistry-Based Affinity Purification and Mass Spectrometry; Lei Fang ; Jingzi Zhang ; Di Shen ; Bin Xue ; Lan Huang ; Chaojun Li ; Nanjing University, Nanjing, China; University of California-Irvine, Irvine, CA Novel Method to Process Proteomics for Identification of Pathways Associated with Anti-Colon Cancer Properties of Anthocyanin-Rich Purple-Fleshed Potato in Mice; Venkata Charepalli ; Vadiraja Bhat ; Lavanya Reddivari ; Jairam Vanamala, 4 ; Pennsylvania State University, University Park, Pennsylvania; Agilent Technologies, Wilmington, DE; The Pennsylvania State University, State College, PA; 4 The Penn State Hershey Cancer Institute, Hershey, PA Top Down Protein Analysis (Applications) MP 708 TopDownLab Proteoform-Specific Monitoring of Multi-Site Protein Phosphorylation; Andrea Mizzi Brunner ; Philip Lössl ; Albert J R Heck ; Maarten A F Altelaar ; Richard A Scheltema ; Utrecht University, Utrecht, Netherlands MP 709 Top-Down Proteomic Study of Sarcomere Protein Post-Translational Modifications in Aging Skeletal Muscle; Liming Wei ; Ziqing Lin ; Yutong Jin ; Wenxuan Cai ; Zachery R. Gregorich ; Ying Ge ; Department of Cell and Regenerative Biology, University of Wisconsin- Madison, Madison; Department of Chemistry, University of Wisconsin-Madison, Madison 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9

92 GENERAL MONDAY INFORMATION POSTERS MP 70 MP 7 MP 7 MP 7 MP 74 MP 75 MP 76 MP 77 MP 78 MP 79 Ultra-Fast Analysis of Hemoglobin Isoforms Using Capillary Electrophoresis Coupled to Mass Spectrometry and Ultraviolet Photodissociation; Andreas Krupke ; Chien-Hsun Chen ; Xiaolei Xie ; Chad R Weisbrod ; Romain Huguet ; Shiaw-Min Chen ; Achim Karger ; Steve Williams ; Michael Wenz ; Andreas Huhmer ; Aran Paulus ; Daniel Lopez-Ferrer ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, South San Francisco, CA Evaluation and Application of Top-Down Mass Spectrometry for Exploring the Low Molecular Weight Proteome of Osteosarcoma Cells; Liping Yang ; Zifeng Song ; Claudia S Maier ; Oregon State University, Corvallis, OR Top-Down Mass Spectrometry Applications for Detection of N-Terminal Sequence Heterogeneity and PTMs for a Therapeutic Molecule; Bao Quoc Tran ; Shivangi Awasthi ; Mohd M Khan ; David R Goodlett ; Young Ah Goo ; University of Maryland Baltimore Targeted Intact Protein Fragmentation in Complex Mixtures Using a Charge State Scheduled Precursor List of Regulated Proteoforms; Jim Kapron ; Rainer Paape ; Markus Lubeck ; Schmit Pierre-Olivier ; Bruker Ltd, Vancouver, Canada; Bruker Daltonic GmbH, Bremen, Germany; Bruker Daltonique S.A., Wissembourg, bas-rhin Investigating Binding Sites of Metal Drugs to Ubiquitin Using Free-Access cheminfo.org Algorithms; Laure Menin ; Ronald F.S. Lee ; Luc Patiny ; Daniel Ortiz ; Paul J. Dyson ; EPFL SB ISIC-GE, Lausanne; EPFL, Lausanne, Switzerland Human Proteoform Identification by Top-Down LC-MS/ MS Utilizing a Tesla FT-ICR Mass Spectrometer; Lissa C Anderson ; Caroline J DeHart ; Nathan K Kaiser ; Donald F Smith ; Christopher L Hendrickson ; NHMFL, Tallahassee, Fl Top-down MS/MS Analysis of Canonical Histone HA Phosphorylation During the Cell Cycle; Xibei Dang ; Michael E Hoover ; Chen Yu ; Alan G Marshall 4, 5 ; Michael A Freitas ; National High Magnetic Field Laboratory, Tallahassee, FL; Ohio State University, Columbus, OH; University of Illinois at Urbana-Champaign, Urbana- Champaign, IL; 4 National High Magnetic Field Laboratory, Tallahssee, FL; 5 Florida State University, Tallahassee, Florida Comprehensive, Quantitative Intact Proteoform Measurements of Patient-Derived Breast Tumor Xenografts Using an Improved Top-Down Proteomics Pipeline; Tao Liu ; Paul D Piehowski ; Samuel H Payne ; Sangtae Kim ; Jungkap Park ; Christopher S Wilkins ; Carrie D Nicora ; Yufeng Shen ; Rui Zhao ; Anil K Shukla ; Ronald J Moore ; Sherri R Davies ; Shunqiang Li ; Reid R Townsend ; Matthew J Ellis ; Emily S Boja 4 ; Henry Rodriguez 4 ; Karin D Rodland ; Richard D Smith ; Pacific Northwest National Laboratory, Richland, WA; Washington University, St Louis, MO; Baylor College of Medicine, Houston, TX; 4 National Cancer Institute, Bethesda, MD Top-Down LC/MS Analysis of Myofilament Proteoforms in Dilated Cardiomyopathy; Yumin Lian ; Ziqing Lin ; Yi- Chen Chen ; Nicole Marie Lane ; Takushi Kohmoto ; Ying Ge ; University of Wisconsin-Madison, Madison, WI YahO Protein as a Calibrant For Top-Down Proteomic Identification of Shiga Toxin Using MALDI-TOF-TOF- MS/MS and Post-Source Decay; Clifton K. Fagerquist ; William James Zaragoza ; USDA/ ARS, Albany, CA MP 70 MP 7 MP 7 MP 7 MP 74 MP 75 Label-Free Quantitative Analysis of Mouse Brain Proteoforms Using Top Down Proteomics; Roderick G. Davis ; Kyunggon Kim ; Paul M Thomas ; Ryan T Fellers ; Richard D Leduc ; VanNispen J Alexandra ; Jonathan Sweedler ; Justin Rhodes ; Neil L Kelleher ; Northwestern University, Evanston, IL; University of Illinois at Urbana- Champaign, Urbana, IL Assessing Organismal and Spatial MBP Proteoform Diversification in Healthy Rats by Top-Down Mass Spectrometry (TDMS); Casey E Wing ; Micheal Tran ; Daniel A Plymire ; John Corbett, ; Steven M Patrie, ; University of Texas at Dallas, Richardson, TX; University of Texas Southwestern Medical Center, Dallas, TX Top-Down Proteomics can Differentiate Closely Related Pathogenic Enterobacteria; Mathieu Dupré ; Valeria Calvaresi ; Christian Malosse ; Magalie Duchateau ; Dominique Clermont ; Julia Chamot-Rooke ; Institut Pasteur, Paris, France Analysis of Proteoforms in Membrane Protein Complexes by Top-Down Proteomics; Hans JCT Wessels ; Sergio Guerrero-Castillo ; Roel Tans ; Schmit Pierre-Olivier ; Stuart Pengelley ; Alain J Van Gool ; Radboudumc, Nijmegen, Netherlands; Bruker Daltonique S.A., Wissembourg, bas-rhin; Bruker Daltonic GmbH, Bremen, Germany Top Down D Spatial Mapping of Myelin Basic Protein Proteoforms: Organism and Spatial Diversification and its Potential Impact on Auto Immunity; Daniel Plymire ; John Corbett, ; Casey Wing, ; Michael Tran, ; Steven Patrie, ; University of Texas Southwestern Medical Center, Dallas, TX; University of Texas at Dallas, Richardson, TX Preparing to Read the Ubiquitin Code: Top-Down Analysis of Polyubiquitin Chains; Amanda Lee ; Lucia Geis-Asteggiante ; Emma Dixon ; Tanuja Kashyap ; Yan Wang ; David Fushman ; Catherine Fenselau ; University of Maryland, College Park, MD MP 76 Identification of Secretory Virulence Factors in S. aureus by Combination of Proteomics Methods; Santosh Misal ; Shital D Ovhal ; Jonathan A Karty ; James P Reilly ; Indiana University Dept. Chemistry, Bloomington, IN MP 77 Top-Down High Resolution Accurate Mass-Mass Spectrometry for Identification of Clinical Yeast Species; Joanna Freeke ; Azadeh Jamalian ; Mansoureh Vatanshenassan ; Bert Gerrits van den Ende ; Helene L Cardasis ; Johan Finell 4 ; Ping F. Yip ; Scott R. Kronewitter ; James Jr L Stephenson ; Alexander Y. Cherkassky ; J. Benjamin Stielow ; Sybren de Hoog ; Thermo Fisher Scientific, Utrecht, Netherlands; CBS-KNAW Fungal Biodiversity Center, Utrecht, Netherlands; Thermo Fisher Scientific, Cambridge, MA; 4 Thermo Fisher Scientific, Vantaa, Finland PAGE 9 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

93 TUESDAY POSTERS Set up all Tuesday posters...7:0 8:00 am Odd-numbered posters present...0:0 am :00 pm Even-numbered posters present...:00 :0 pm Remove all Tuesday posters...7:0 8:00 pm Antibodies & Antibody Drug Conjugates (Separations) Biomarkers: Quantitative Analysis (Part ) Biomolecular Structure Analysis: Chemical Crosslinking and Covalent Labeling (Cross-Linking) Data Independent Acquisition (SWATH) Diagnostic Clinical Chemistry (General) Drug Discovery/DMPK/ADME (Applications) Drug Metabolism: Qualitative and High Throughput Analysis Energy: Hydrocarbon and Petrochemical (Hi Res and Nominal) Environmental Analysis: General (Part ) FAIMS and DMS Food Safety (Pesticides in Food) Food omics MS Characterization of Food and Nutritional Supplements (Part ) Forensics (Part ) Glycoproteins High Mass Accuracy/High Performance MS Methods & Developments Imaging MS: Disease Markers Imaging MS: Pharmaceutical Applications Informatics: Peptide ID and Quantification Instrumentation: General Instrumentation: New Developments in Mass Analyzers Ion Mobility: Applications (Proteins & Peptides) LC-MS: Chromatography and Software (Part ) Lipids: ID and Structural Analysis Metabolomics: Sample Preparation Metabolomics: Untargeted Metabolite Profiling (Cells/Plants) Nucleic Acids Peptides: PTM Identification Phosphopeptides: Quantitative Analysis Proteins: Complexes/Non-covalent Interactions Proteomics: Clinical Applications (Development toward Clinical Application) Proteomics: Infectious Diseases Proteomics: Quantitative (Application Biological Research) Small Molecules: Quantitative Analysis (Animal, Plant/Insect, and Methodology) Top Down Protein Analysis (Methodology) Antibodies & Antibody Drug Conjugates (Separations) TP 00 A Sensitive Multidimensional Liquid Chromatography Method for the Characterization of Free Drug Impurities in Antibody-drug Conjugates using Mass Spectral Detection; Robert Birdsall ; Sean M McCarthy ; Alain Beck ; John Gebler ; Weibin Chen ; Waters Corporation, Milford, MA; Waters, Milford, MA; Pierre Fabre, St Julienen-Genevois, France TP 00 Characterization and Spectral Library Building of Glycopeptides in the Tryptic Digest of a Monoclonal Antibody Using D and D LC-MS/MS; Qian Dong ; Xinjian Yan ; Yuxue Liang ; Stephen Stein ; NIST, Gaithersburg, MD; NIST, Rockville, MD TP 00 DAR Calculation of Cysteine Linked ADCs by Reversed Phase High Performance Liquid Chromatography Tandem High Resolution mass spectrometry; Shuai Zuo ; Tao Bo ; Agilent Technologies (China) Limited, Beijing, China TP 004 TP 005 TP 006 TP 007 TP 008 TP 009 TP 00 TP 0 TP 0 TP 0 TP 04 TP 05 Characterization of Antibody Drug Conjugate: Intact, Fragment and Peptide Mapping using Reversed Phase Columns; Suresh Babu Cv ; Tang Ning ; Anne Blackwell ; Agilent Technologies, Bangalore, Karnataka; Agilent Technologies, Santa Clara, CA; Agilent Technologies, Little Falls, DE Comparison of Innovator and Biosimilar by Peptide Mapping using HPLC Coupled to Time-of-Flight Mass spectrometry; Ravindra Gudihal ; Ning Tang ; Agilent Technologies India Pvt. Ltd, Bangalore, Karnataka; Agilent Technologies, Santa Clara, CA Towards the Complete Characterization of Host Cell Proteins in Biotherapeutics via Affinity Depletions, LC-MS/MS, and Multivariate Analysis; Jennifer Murphy ; James A. Madsen ; Victor Farutin ; Yan Yin ; Stephen Smith ; James Anderson ; Ishan Capila ; Momenta Pharmaceuticals, Cambridge, MA; Momenta Pharmaceuticals, Cambridge, ma Reversed-Phase Separation of Therapeutic Monoclonal Antibodies Using Superficially Porous Column: LC/MS Analysis; Suresh Babu Cv ; Ning Tang ; Anne Blackwell ; Agilent Technologies, Bangalore, Karnataka; Agilent Technologies, Santa Clara, CA; Agilent Technologies, Little Falls, DE Rapid Automated LC-MS/MS Glycan Analysis for Monoclonal Antibodies; Bhavana Shah ; Jason Richardson ; Zhongqi Zhang ; Amgen Inc.,, Thousand Oaks, CA; Amgen, Inc., Thousand Oaks, CA Towards the Automated Monoclonal Antibody Sequencing and Characterization from LC-MS data; Lin He ; Mohammad Ziaur Rahman ; Ngoc Hieu Tran ; Baozhen Shan ; Ming Li ; Bioinformatics Solutions Inc., Waterloo, Canada; David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, ON Development of a Non-Toxic Antibody Drug Conjugate Mimic to Enable LC-MS Method Development Without Risk; Kevin Ray ; Brian Gau ; John Dapron ; Nicolas Caffarelli ; Jeffrey Turner ; MilliporeSigma, St Louis, MO Characterisation of Antibody Conjugates under Denaturing Liquid Chromatography Mass Spectrometry (MS) and Native MS Conditions; Kersti Karu, ; Maurício Morais ; James R Baker ; UCL Chemistry Mass Spectrometry Facility, London; Department of Chemistry, Christopher Ignold Building, London, UK Electrospray-Ionization Time-of-Flight Mass Spectrometry Coupled to Online, Comprehensive Two-Dimensional Liquid Chromatography for the Characterization of Therapeutic Monoclonal Antibodies; Matthew Sorensen ; David Christopher Harmes ; Gregory O Staples ; Szabolcs Fekete, 4 ; Davy Guillarme, 4 ; Alain Beck 5 ; Dwight Stoll ; Gustavus Adolphus College, Saint Peter, MN; Agilent Technologies, Santa Clara, CA; University of Geneva, Geneva, Switzerland; 4 University of Lausanne, Geneva, Switzerland; 5 Center for Immunology Pierre Fabre, Saint-Julien-en-Genevois, France Native Liquid Chromatography-Mass Spectrometry Applied to the Validation of Drug to Antibody Ratio LC-UV Methods and Antibody Drug Conjugates Development; Lieza Danan-Leon ; Guillaume Tremintin ; stemcentrx, South San Francisco, CA; Bruker Daltonics, Fremont, CA Direct Analysis of Intact mab s and Low Abundant Variants by Advanced LC-MS Approaches; Xiaomei (Annie) He ; Janet Lau; Chen Li; Shiaw-Lin Wu; BioAnalytix, Cambridge, MA Mass Spectrometric Characterization of HalfmAb Separated from Intact Monoclonal Antibody and Fragments using Analytical Size Exclusion Chromatography Column; Crystal Benner ; William Evans ; Cesar Zuin ; Kyle Root ; Kerney Jebrell Glover ; 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9

94 GENERAL TUESDAY INFORMATION POSTERS TP 06 TP 07 TP 08 TP 09 TP 00 TP 0 TP 0 TP 0 TP 04 TP 05 Atis ChakrabartI 4 ; tosoh Bioscience LLC, King of Prussia, PA; lehigh University, Bethlem, PA; lehigh University, Bethlehem, PA; 4 Tosoh Bioscience LLC, King of Prussia, PA LC-MS Characterization of Proteolytic Cleavage Sites in Therapeutic Monoclonal Antibodies; Pavel V. Bondarenko ; Thomas M Dillon ; Gang Xiao ; Nicole Ball ; Deirdre M Piedmonte ; Michael J Treuheit ; Amgen, Inc., Thousand Oaks, CA; Amgen, Inc., Thousand Oaks, CA Probing Higher-Order Structural Changes of a Lysine-linked Antibody-Drug Conjugate by Hydrogendeuterium Exchange Mass Spectrometry (HDXMS); Lintao Wang ; Alexandru C. Lazar ; ImmunoGen Inc., Waltham, MA; ImmunoGen, Inc., Waltham, MA A New Workflow for Characterization of Antibody Mixtures via Slip Flow Chromatography and Ultraviolet Photodissociation for Top-Down Mass Spectrometry; Luca Fornelli ; Philip Compton ; Ximo Zhang ; Mary Wirth ; Neil Kelleher ; Northwestern University, Evanston, IL; Purdue University, West Lafayette, IN Glycoform Separation and Characterization of Cetuximab Variants by Middle-up Off-line CE-UV/ESI- MS; Nassur Said ; Michael Biacchi ; Rabah Gahoual, ; Charly Renard ; Alain Beck ; Yannis-Nicolas Francois ; Emmanuelle Leize-wagner ; Laboratoire de Spectrométrie de Masse des Interactions et des Systèmes (LSMIS), CNRS UMR740, University of Strasbourg, Strasbourg, France; Division of BioAnalytical Chemistry, AIMMS Research Group BioMolecular Analysis, VU University Amsterdam, Amsterdam, The Netherland; Centre d Immunologie Pierre Fabre, Saint-Julien-en-Genevois, France High-order Structural Interrogation of Antibody-drug Conjugates by a Combination of Intact, Middle-up and Bottom-up Techniques using Sheathless Capillary Electrophoresis-Mass Spectrometry; Nassur Said ; Rabah Gahoual, ; Laurianne Kuhn ; Alain Beck 4 ; Yannis- Nicolas Francois ; Emmanuelle Leize-wagner ; Laboratoire de Spectrométrie de Masse des Interactions et des Systèmes (LSMIS), CNRS UMR740, University of Strasbourg, Strasbourg, France; Division of BioAnalytical Chemistry, AIMMS Research Group BioMolecular Analysis, VU University Amsterdam, Amsterdam, The Netherland; Institut de Biologie Moléculaire et Cellulaire (IBMC), University of Strasbourg, Strasbourg, France; 4 Centre d Immunologie Pierre-Fabre, St. Julien-en-Genevois, France Microchip Capillary Electrophoresis with Integrated ESI- MS for the Detailed Analysis of Intact Biotherapeutic Antibodies and ADCs; J. Scott Mellors ; Erin Anne Redman ; J. Michael Ramsey ; 908 Devices, Inc., Chapel Hill, NC; University of North Carolina, Chapel Hill, NC Capillary Electrophoresis Mass Spectrometry for Top Down Proteomics; Andreas Krupke ; Shiaw-Min Chen ; Achim Karger ; Michael Wenz ; Daniel Lopez-Ferrer ; Aran Paulus ; Thermo Fisher Scientific, South San Francisco, CA; Thermo Fisher Scientific, San Jose, CA Intact Immunoglobulin Gamma Analysis by CESI-MS; Bryan Fonslow, ; Olga Friese ; Ying Zhang ; John Yates III ; K. Steven Cook ; Jason Rouse 4 ; SCIEX, San Diego, CA; The Scripps Research Institute, La Jolla, CA; Pfizer, Chesterfield, MO; 4 Pfizer, Inc. Andover, MA Characterization of Monoclonal Antibody Charge Variants using OFFgel Fractionation and Mass Spectrometry; Alyssa Neill ; Yekaterina Kori ; Guilong Charles Cheng ; Hongcheng Liu ; Alexion Pharmaceuticals Inc., New Haven, CT; University of Massachusetts Amherst, Amherst, Massachusetts Bioanalytical Challenges of Next-Generation Antibody- Drug-Conjugates Case Study: Developing a nd- Generation Affinity Capture LC-MS to Improve In Vivo Stability Assessment; Dian Su; Genentech Inc, South San Francisco, CA TP 06 TP 07 TP 08 Novel Microfluidic Chip with In-line Deglycosylation for Rapid Mass Analysis of Reduced Monoclonal Antibodies; Loredana Serafini ; John Corbin ; Victoria Smith ; Mark Nagel ; Leanna Lagpacan ; Debi Jin ; Andy Gieschen ; Caroline S. Chu ; Katherine Brendza ; Gilead Sciences, Foster City, CA; Agilent Technologies, Santa Clara, CA Multidimensional ionkey/ms for Antibody Drug Conjugate Analysis; Greg Roman ; James P Murphy ; Waters, Milford, MA Using Hydrophilic Interaction Chromatography Mass Spectrometry for Heightened Product Characterization to Overcome Challenges with Hydrophobic Antibodies and Antibody Drug Conjugates; Jacquelynn Smith ; Matthew Lauber ; Stephan Koza ; Erin Chambers ; Jason C Rouse ; Olga Friese 4 ; Senior Associate Scientist at Pfizer, Chesterfield, MO; Waters, Milford, MA; Pfizer, Inc. Andover, MA; 4 Pfizer, Chesterfield, MO Biomarkers: Quantitative Analysis (Part ) TP 09 Towards Absolute Quantification of Protein Expression in D Tissue Culture Samples by MALDI-IMS-MS Imaging; Rebecca Day ; Amanda Harvey ; Laura M Cole ; Neil Cross ; David Smith ; Malcolm Clench ; Sheffield Hallam University, Sheffield, United Kingdom TP 00 Double Standards in Proteomics: DOSCATS: Engineered Peptide/Epitope Concatenations for SRM or Western Blotting; Robert Beynon ; Richard J Bennett ; Deborah M Simpson ; Stephen W Holman ; John Colyer, ; University of Liverpool, Liverpool, United Kingdom; University of Leeds, Leeds, United Kingdom; Badrilla Ltd., Leeds, UK TP 0 Development of New LC-MS Methodologies to Assess Liver Function in a Clinical Setting using Plasma and Dried Blood Spot; Lei Guo ; Raymond Gonzalez ; Kara Pearson ; Elizabeth Joshi ; Kevin P Bateman ; Daniel S Spellman ; Merck & Co., Inc., West Point, PA; Merck & Co, Kenilworth, NJ TP 0 Serial Lectin Affinity Chromatography for Comparative Serum Glycoproteomics on Colon Cancer Biomarker Discovery; Jinwook Lee ; Wonryeon Cho ; wonkwang University, Iksan, Jeonbuk TP 0 Between Good, Fast and Cheap: Method Development for Large-Scale Plasma-Proteome Analysis between the Antagonizing Poles of Sensitivity, Through-put and Costs; Christoph Stingl ; Lennard Dekker ; Diana A T Nijholt ; Coskun Güzel ; Martijn M. van Duijn ; Theo M. Luider ; Erasmus Medical Center, Rotterdam, The Netherlands TP 04 Comparative Proteomic Analysis of Kidney Distal Convoluted Tubule and Cortical Collecting Duct Cells following Long-Term Hormonal Stimulation; Qi Wu ; Trairak Pisitkun ; Robert Fenton ; Center for Interactions of Proteins in Epithelial Transport, Department of Biomedicine, Aarhus, Denmark; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand TP 05 Higher Protein Identifications and Coverage May Not Correlate with Higher Numbers of PSMs or Peptides in Quantitative Proteomic Analyses; Lauren Devine ; Tatiana Boronina ; Robert N O Meally ; Robert N Cole ; Johns Hopkins University School of Medicine, Baltimore, MD TP 06 Identification of Pathologicalα-Synuclein Forms in Brain Extracts from Patients with Parkinson s Disease by Selected Reaction Monitoring; Payel Bhattacharjee ; Ann Brinkmalm ; Annika Öhrfelt ; Kaj Blennow ; Henrik Zetterberg ; University of Gothenburg, Mölndal, Sweden TP 07 Development of a TFPI (Tissue Factor Pathway Inhibitor) Protein Quantification Assay; Katherine Wright; Pfizer, Andover, MA PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

95 TUESDAY POSTERS TP 08 TP 09 TP 040 TP 04 TP 04 TP 04 TP 044 TP 045 TP 046 TP 047 TP 048 TP 049 A High-throughput Platform for Mass Spectrometric Analysis of Serum Fucosylated Haptoglobin in Hepatocellular Carcinoma; Jianhui Zhu ; Jing Wu ; Haidi Yin ; Jorge Marrero ; David M Lubman ; University of Michigan Medical Center, Ann Arbor, MI; University of Texas Southwestern Medical Center, Dallas, TX Development of Plasma Protein Biomarkers for Effects of Radiation Exposure Using Quantitative Mass Spectrometry; Kate Liu ; Dyna Shirasaki ; Elizabeth Singer ; William McBride ; Julian Whitelegge ; Joseph A. Loo ; UCLA, Los Angeles, CA Phosphoproteomic Analysis of Differential Protein Expression in BRaf-Mutated Melanoma Cells with Acquired Resistance to BRaf, MEK/, or ERK/ Inhibitors; Shivangi Awasthi ; Jacob Sheenstra ; Bao Tran ; Young Ah Goo ; Paul Shapiro ; David R Goodlett ; University of Maryland Baltimore, Baltimore, USA Identification of Novel Glycoprotein Biomarkers for Distinguishing Intestinal Inflammation from Fibrosis in Crohn s Disease by LC-MS/MS; David M Lubman ; Jing Wu ; Ryan Stidham ; Peter Higgins ; Henry Appelman ; University of Michigan Medical Center, Ann Arbor, MI LC-MS/MS Method for Quantitation of Seven Biomarkers in Human Plasma for the Assessment of Impaired Glucose Tolerance; Qibo Zhang ; Lisa A Ford ; Kelli D Goodman ; Tiffany A Freed ; Deirdre M Hauser ; Jessie K Conner ; Kate E T Vroom ; Klaus-Peter Adam ; Michael V Milburn ; Douglas R Toal ; Metabolon, Inc., Durham, NC A Robust Analytical LC-MS/MS Method to Quantitate Plasma Itraconazole and Hydroxy-Itraconazole in Patients with Solid Tumors; Claudia Meek ; Erling Beck ; Richard Leff ; Texas Tech University, Dallas, TX; Texas Tech University Health Sciences Center, Dallas, TX Investigation of the Quantitative Properties of Micro Flow LC-MS/MS for Direct Analysis of Frataxin in Human Biopsy; Qishan Lin ; Jinghua Zhu ; University at Albany, Rensselaer, NY; University at Albany, Rensselaer, NY Ultra high Performance Liquid Chromatography- Tandem Mass Spectrometry (UHPLC-MS/MS) Platform for Clinical Diagnostics within Diabetes Care; Linda Ahonen ; Sirkku Jäntti ; Matej Orešič ; Tuulia Hyötyläinen ; Steno Diabetes Center A/S, Gentofte, Denmark; University of Helsinki, Helsinki, Finland Quantitative Discovery of the Alterations of the Entire Human Kinome in Human Cells upon Methylglyoxal Treatment; Weili Miao ; Lei Guo ; Yongsheng Xiao ; Xiaogang Jiang ; Yinsheng Wang ; University of California, Riverside, Riverside, CA A Comprehensive Investigation towards the Indicative Proteins of Bladder Cancer in Urine: From Surveying Cellular Secretomes to Verifying Urine Proteins; Jiao Guo;, Beijing, Beijing Development of MS Based Clinical Assays for Measuring Cerebrospinal Fluid Levels of Pre-Synaptic Proteins in Alzheimer s Disease; Ann Brinkmalm ; Gunnar Brinkmalm ; Henrik Zetterberg, ; Kaj Blennow ; Annika Öhrfelt ; University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology, London, UK Quantification of Hepcidin-5 in human Cerebrospinal Fluid using LC-MRM; Jerome Vialaret ; Constance Delaby ; Pauline Bros, ; Amandine Moulinier ; Vincent Delatour ; Audrey Gabelle 4 ; Sylvain Lehmann ; Christophe HIRTZ ; LBPC, IRMB CHU Montpellier St. Eloi Montpellier, France; Laboratoire National de Métrologie et d Essais, Paris, France; Laboratoire National de Métrologie et d Essais, Paris, france; 4 Centre Mémoire Ressources CHRU Montpellier, Montpellier, France TP 050 TP 05 TP 05 TP 05 TP 054 Measurement of DNA Repair Protein Apurinic/ Apyrimidinic Endonuclease (APE) in Human Tissues by Liquid Chromatography/Tandem Mass Spectrometry with Isotope Dilution; Pawel Jaruga ; Fatos Guldal Kirkali ; Prasad T. Reddy ; Alessandro Tona ; Bryant C. Nelson ; Mengxia Li 4 ; David M. Wilson, III 5 ; Erdem Coskun 6 ; Miral Dizdar 6 ; NIST, Gaithersburg, MD; NIH/NCI (National Cancer Institute), Bethesda, MD; NIST, Gaithersburg MD; 4 NIH/NIA/IRP, Baltimore, MD; 5 NIH/NIA (National Institute on Aging), Baltimore, MD; 6 NIST, Rockville, MD Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT AML Cells; Catrin Roolf ; Nikolaj Dybowski ; Anett Sekora ; Stefan Mueller ; Gudrun Knuebel ; Hugo Murua Escobar ; Klaus Godl ; Andreas Tebbe ; Christian Junghanss ; Christoph Schaab ; Rostock, University Medical Center, Department of Hematology/ Oncology/ Palliative Care, Rostock, Germany; Evotec (München) GmbH, Munich, Germany Improved Quantification of Rat Plasma NNK and NNAL Using Protein Precipitation and Phospholipid Removal in UFLC-ESI/MS/MS; Estatira Sepehr ; Matthew S Bryant ; National Center for Toxicological Research, FDA, Jefferson, AR; National Center for Toxicological Research - FDA, Jefferson, AR Accurate Quantification of Peptide using Multiple Internal Standards in Conjunction with parallel reaction monitoring; Sebastien Gallien ; Bruno Domon ; Luxembourg Clinical Proteomics Center, Strassen, Luxembourg Precise MRM-based Quantitation of 00 Proteins from Dried Blood Spots and Single Drops of Blood; Jingxi Pan ; Suping Zhang ; Albert Chou ; Christoph H. Borchers,4 ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; MRM Proteomics, Inc., Victoria, BC, Canada; University of Victoria - Genome BC Proteomics Centre, Victoria, BC; 4 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada Biomolecular Structure Analysis: Chemical Crosslinking and Covalent Labeling (Cross- Linking) TP 055 The Synaptic Vesicle Cycle is Governed by Heterogeneous and Macromolecular Protein Microdomains; Carla Schmidt; HALOmem, University of Halle, Halle / Saale TP 056 Structure of α-synuclein Determined by Structural Proteomics and Constraint-Driven Discrete Molecular Dynamic Modeling; Nicholas I Brodie ; Konstantin I Popov ; Evgeniy V Petrotchenko ; Nikolay V Dokholyan ; Christoph H. Borchers, ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; University of North Carolina, School of Medicine, Chapel Hill, NC; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada TP 057 Profiling Yeast Mitochondrial Protein-Protein Interactions in a Whole-Organelle Scale by Cross- Linking Mass Spectrometry; Chung-Tien Lee, ; Peter Rehling ; Henning Urlaub, ; Max Planck Institute for Biophysical Chemistry, Goettingen, Germany; University Medical Center (UMG), Goettingen, Germany TP 058 Transcription Factor-DNA Interaction Studied by Structural Mass Spectrometry; Lukas Slavata, ; Michal Rosulek, ; Daniel Kavan, ; Alan Kadek, ; Hynek Mrazek, ; Petr Man, ; Petr Novak, ; Institute of Microbiology CAS, Prague, Czech Republic; Faculty of Science, Charles University in Prague, Prague, Czech Republic 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 95

96 GENERAL TUESDAY INFORMATION POSTERS TP 059 TP 060 TP 06 TP 06 TP 06 TP 064 TP 065 TP 066 TP 067 TP 068 Assessing the Performance of CID-cleavable crosslinkers and Subsequent Data Analysis Strategies; Rebecca Beveridge ; Karl Mechtler ; Research Institute of Molecular Pathology (IMP), Vienna, Austria Improving Cross-linked Peptide Identification in Large Protein Complexes on Quadrupole-Orbitrap and Quadrupole-Orbitrap-Ion Trap Platforms; Chung- Tien Lee ; Olexandr Dybkov ; Christof Lenz, ; Thomas Monecke ; Ralf Ficner ; Yue Xuan 4 ; Henning Urlaub, ; Max Planck Institute for Biophysical Chemistry, Goettingen, Germany; University Medical Center (UMG), Goettingen, Germany; Georg August University, Goettingen, Germany; 4 Thermo Fisher Scientific, Bremen, DE Optimization of Crosslinked Peptide Analysis on an Orbitrap Fusion Lumos Mass Spectrometer; Ryan Bomgarden ; Erum Raja ; Chris Etienne ; Fan Liu ; Albert J R Heck ; Mathias Mueller ; Rosa I Viner 4 ; Thermo Fisher Scientific, Rockford, IL; Utrecht University, Utrecht, The Netherlands; Thermo Fisher Scientific, Bremen, DE; 4 Thermo Fisher Scientific, San Jose, CA Structural Proteomics Analysis of the Native Tau Protein; Karl A T Makepeace ; Evgeniy V Petrotchenko ; Christoph H. Borchers, ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, CANADA; University of Victoria - Genome BC Proteomics Centre, Victoria, BC; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, CANADA Evaluation of a Photo-Activatable Unnatural Amino Acid Engineered Into Proteins To Crosslink And Identify interaction partners; Robert Hettich ; Chen Qian ; Steven King ; Melinda Hauser ; Jeffrey Becker ; Oak Ridge National Laboratory, Oak Ridge, TN; University of Tennesse, Knoxville, TN Analysis of UV-induced DNA-protein cross-links in a chromatin model by mass spectrometry; Alexandra Stuetzer ; Christin Kappert ; Aleksandar Chernev ; Wolfgang Fischle, ; Henning Urlaub ; Max Planck Institute for Biophysical Chemistry, Goettingen, Germany; KAUST, Thuwal, Saudi Arabia RNPxl - Protein-RNA Interaction Site Localization from UV Cross-linked Peptide-RNA Oligonucleotides in Proteome Discoverer.; Timo Sachsenberg ; Johannes Veit ; Aleksandar Chernev ; Kundan Sharma ; Romina Hofele ; Saadia Qamar ; Uzma Zaman ; Christin Kappert ; Katharina Kramer ; Julianus Pfeuffer 4 ; Xiao Liang 4 ; Knut Reinert 4, 5 ; Christof Lenz ; Henning Urlaub ; Oliver Kohlbacher, 6 ; Eberhard Karls University, Tübingen, Germany; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany; Max Planck Institute for Plant Breeding Research, Köln, Germany; 4 Freie Universität Berlin, Berlin, Germany; 5 Max Planck Institute for Molecular Genetics, Berlin, Germany; 6 Max Planck Institute for Developmental Biology, Tübingen, Germany Novel Workflow for Characterization of Non-Disulfide Protein Crosslinks in Normal and Cataractous Human Lens; Ruiqiang Chen ; Kristie L. Rose ; Zhen Wang ; Kevin Schey ; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN New Methodology for the in vivo Identification of Protein Partners using Genetically Encoded Unnatural Amino Acids and Mass Spectrometry; Mariana Fioramonte ; Bing Yang ; Ana Gisele C Neves-Ferreira ; Lei Wang ; Fabio César Gozzo ; University of Campinas, Campinas, Brazil; UCSF, San Francisco, CA; Fiocruz, Rio de Janeiro, RJ Systematic Determination of Nuclear Pore Complex Protein Interfaces by XL-MS; Joseph Glavy ; Martin Beck ; Stevens Institute of Tech., Hoboken, NJ; EMBL Heidelberg, Heidelberg, Germany TP 069 TP 070 TP 07 TP 07 TP 07 TP 074 TP 075 TP 076 TP 077 Quantitative Cross-linking/LCMS (CX-MS) to Investigate Allosteric Regulation of Phosphodiesterase 6 (PDE6); Donna Hogan ; Xiongzhuo Gao ; Suzanne Matte ; Rick Cote ; Feixia Chu ; University of New Hampshire, Durham, NH Developing a Novel Multiplexed Quantitative Crosslinking Mass Spectrometry Strategy to Define the Structural Dynamics of Cullin-RING Ligase Complex; Clinton Yu ; Haibin Mao ; Alex Huszagh ; Rosa I Viner ; Eric Novitsky ; Tonya Second ; Scott Rychnovsky ; Ning Zheng ; Lan Huang ; University of California, Irvine, Irvine, CA; University of Washington, Seattle, WA; Thermo Fisher Scientific, San Jose, CA Developing A Novel Acidic Residue Reactive and Sulfoxide-containing MS-cleavable Homobifunctional Cross-linker for Studying Protein-Protein Interactions; Craig Bryant Gutierrez ; Clinton Yu ; Alex Huszaugh ; Eric Novitsky ; Scott Rychnovsky ; Lan Huang ; UC-Irvine, Irvine, CA Structural Analysis of a Myotoxin-antimytoxin Complex by Cross-linking, Mass Spectrometry and Bioinformatics; Barbara S. Soares ; Surza L. G. Rocha ; Diogo B. Lima ; Bruno Lomonte ; Gilberto B Domont 4 ; Jonas Perales ; Richard H. Valente ; Francisco Gomes-Neto ; Ana Gisele Neves-Ferreira ; Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil; Carlos Chagas Institute, Fiocruz, Curitiba, Brazil; Clodomiro Picado Institute, University of Costa Rica, San José, Costa Rica; 4 Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Photocrosslink Coupled with Mass Spectrometry on a Transmembrane Protein Pump using an Unnatural Amino Acid, Benzoylphenylalanine; Thao Nguyen ; Grzegorz Sabat ; Michael Sussman ; UW Madison, Madison, WI; UW-Madison, Madison, WI In vivo Conformational Dynamics of Hsp90 and Its Interactors; Juan Chavez ; Devin K Schweppe ; Jimmy K Eng ; James E Bruce ; University of Washington, Seattle, WA An Integrated Workflow for Analysis of Proteins and Protein Complexes based on Cross-Linking/Mass Spectrometry with an MS/MS Cleavable Cross-Linker; Christian Arlt ; Michael Goetze ; Christian Ihling ; Christoph Hage ; Mathias Schaefer ; Andrea Sinz ; Martin-Luther- Universität, Halle-Wittenberg, Germany; Universität zu Köln, Greinstrasse, Germany Data Independent Acquisition (SWATH) Large-scale Quantitative Measurements of Rat Brain Hippocampus Membrane Proteome in Prolonged Simulated Microgravity Model by D-SWATH Mass Spectrometry; Peibin Qin ; Yun Wang ; Lihai Guo ; Yongqian Zhang ; Wenhai Jin ; Yulin Deng ; Shanghai AB Sciex Analytical Instrument Trading Co.,Ltd.,China, Beijing, China; School of Life Science,Beijing Institute of Technology,China, Beijing, China An Novel Alignment Strategy for SWATH-MS to Generate Comprehensive Proteomics Data Matrices; Hannes Luc Röst, ; Yansheng Liu ; Giuseppe D Agostino ; Matteo Zanella ; Pedro Navarro 4 ; George Rosenberger ; Ben Collins ; Ludovic Gillet ; Giuseppe Testa ; Lars Malmström ; Ruedi Aebersold ; ETH Zurich, Zürich, Switzerland; Stanford University School of Medicine, Palo Alto CA; Department of Experimental Oncology, European Institute of Oncology (Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS), Milan, Italy; 4 Institute for Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

97 TUESDAY POSTERS TP 078 TP 079 TP 080 TP 08 TP 08 TP 08 TP 084 TP 085 TP 086 TP 087 TP 088 TP 089 Assessing Proteome Organization by Native SEC Coupled to SWATH-MS; Moritz Heusel ; George Rosenberger ; Robin Hafen ; Ben C. Collins ; Matthias Gstaiger ; Ruedi Aebersold, ; Institute of Molecular Systems Biology ETH Zurich, Zurich, Switzerland; Faculty of Science, University of Zurich Zurich, Switzerland Understanding the Square-Wave Nature of Q Isolation for Data Independent SWATH Acquisition; Randy J. Arnold ; Leroi Desouza ; Christie Hunter ; Patrick Pribil ; SCIEX, Concord ON, Canada; SCIEX, Redwood City, CA Extending the Depth of Coverage in SWATH Acquisition with Deeper Ion Libraries; Joerg Dojahn ; Nick Morrice ; Christie Hunter ; SCIEX, Darmstadt, Germany; SCIEX, Warrington, UK; SCIEX, Redwood City, CA The Use of Smaller Q Isolation Windows Improves Reproducibility in SWATH Based Protein Quantification Even at Higher Spectral Acquisition Rate; Dipankar Malakar ; Faraz Rashid ; Manoj Pillai ; SCIEX, Udyog Vihar Phase IV Gurgaon, India Identification and Quantitation of Glycopeptides by SWATH Acquisition; Chi-Hung Lin ; Christoph Krisp, ; Mark Molloy, ; Macquarie University, Sydney, Australia; Australian Proteome Analysis Facility, Sydney, Australia; Australian Proteome Analysis Facility, Sydney, Australia Using Scanning SWATH Windows to Improve both Quantitative and Qualitative Data over Conventional SWATH and IDA Methodologies; Nic Bloomfield ; Michael Murphy ; Gordana Ivosev ; Stephen Tate ; SCIEX, Concord ON, Canada Glycopeptide SWATH Analysis a Workflow for Quantification of Glycopeptides in Complex Samples; Miloslav Sanda ; Nathan Edwards ; Radoslav Goldman ; Georgetown University, Lombardi Cancer Center Washington, DC; Georgetown University, Department of Biochemistry and Molecular & Cellular Biology, Washington, DC Scrutinization of Library Building for SWATH Analysis; Katleen Van Steendam ; Elisabeth Govaert ; Maarten Dhaenens ; Liesbeth Vossaert ; Dieter Deforce ; Ghent University, Laboratory of Pharmaceutical Biotechnology, Ghent, BELGIUM SWATH-MS Proteomics and Chemometrics to Study the Cardiovascular Disease; Marcello Manfredi ; Eleonora Conte ; Carmela Chiariello ; Elisa Robotti 4 ; Elia Ranzato 4 ; Simona Martinotti 4 ; Eleonora Mazzucco 4 ; Fabio Gosetti 4 ; Annalisa Castagna ; Daniela Cecconi 5 ; Oliviero Olivieri ; Emilio Marengo 4 ; ISALIT-DISIT, University of Piemonte Orientale, Alessandria, Italy; ISALIT, spin-off DISIT, University of Piemonte Orientale, NOVARA, IT; Department of Medicine, University of Verona, Verona, Italy; 4 DISIT, University of Piemonte Orientale, Alessandria, Italy; 5 Department of Biotechnology, University of Verona, Verona, Italy Make Love, Not War: Towards a Comprehensible Workflow for the Integrated Analysis of Transcriptomics and Proteomics Data; Katleen Van Steendam ; Elisabeth Govaert ; Liesbeth Vossaert ; Maarten Dhaenens ; Filip Van Nieuwerburgh ; Laura De Clerck ; Dieter De Coninck ; Dieter Deforce ; Ghent University, Laboratory of Pharmaceutical Biotechnology, Ghent, Belgium Single Shot Deep DIA Methods with Optimal Coverage, Reproducibility and Quantification Precision; Roland Bruderer ; David Gomez-Valera ; Oliver M Bernhardt ; Tejas P Gandhi ; Lukas Reiter ; Biognosys AG, Schlieren, Switzerland; Max Planck Institute for Biophysical Chemistry, Goettingen, Germany Accelerating Data Independent Acquisition with Microflow Chromatography; Christie Hunter ; Nick Morrice ; SCIEX, Redwood City, CA; SCIEX, Phoenix House Lakeside Drive Warrington Cheshire UK TP 090 TP 09 TP 09 TP 09 TP 094 TP 095 Proteome-wide Turnover Analysis Quantifies Genetic Impact in Down Syndrome; Yansheng Liu ; Christelle Borel ; Li Li ; Torsten Mueller ; Paul Boersema 4 ; Pierre-Luc Germain 5 ; Giuseppe Testa 5 ; Andreas Beyer ; Stylianos Antonarakis ; Ruedi Aebersold ; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland; Department of Genetic Medicine and Development, University of Geneva Medical School, and University Hospitals of Geneva, Geneva, Switzerland; University of Cologne, Cologne, Germany; 4 Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland; 5 Department of Experimental Oncology, European Institute of Oncology, Milan, Italy Rapid Ion Mobility Deconvolution for High-throughput Analysis of Structural Isomers; Michael E Pettit ; Matthew R Brantley ; Touradj Solouki ; Baylor University, Waco, TX Phospholipid Analysis Utilising a Novel, Data Independent, Mode of Acquisition on a QTof Instrument with a Scanning Quadrupole Mass Filter; Jayne Kirk ; Steven Lai ; Jason Wildgoose ; Keith Richardson ; Martin Green ; Paul Doorbar ; Witold Niklewski ; Kirsten Craven ; Mark Wrona ; Waters Corporation, Wilmslow, UK; Waters Corporation, Beverly, MA; Waters Corporation, Milford, MA Data-independent Acquisition (DIA) Reveals Changes in Mouse Cardiac Proteome from SS- Drug Intervention; Ying Sonia Ting ; Ying Ann Chiao ; Gennifer E Merrihew ; Peter Rabinovitch ; Michael J MacCoss ; University of Washington, Seattle, WA MS Based Quantification Optimization on DIA Methods on a Quadrupole-Orbitrap Mass Spectrometer; Roland Bruderer ; Yue Xuan ; Oliver M Bernhardt ; Tejas Gandhi ; Thomas Moehring ; Lukas Reiter ; Biognosys AG, Schlieren, Switzerland; Thermo Fisher Scientific, Bremen, DE Data-independent Acquisition Mass Spectrometry- Based Proteomics of Thyroid Cancer Allows Comprehensive Identification of Malignancy-Associated Changes; Juan Martinez-Aguilar, ; Roderick Clifton-Bligh ; Mark Molloy, 4 ; National Autonomous University of Mexico, Mexico city, MEXICO; Macquarie University, Sydney, Australia; Kolling Institute of Medical Research, Sydney, Australia; 4 Australian Proteome Analysis Facility, Sydney, Australia Diagnostic Clinical Chemistry (General) TP 096 Touch Paper Spray Ambient Mass Spectrometry for Paper-based Immunoassays: Towards On-demand Diagnosis; Suming Chen ; Qiongqiong Wan ; Abraham Kwame Badu-Tawiah ; Department of Chemistry and Biochemistry, The Ohio State Univeristy, Columbus, OH TP 097 Real Time and Accelerated Stability Studies of Testosterone Calibrators; Linda Nagore ; Ravi Orugunty ; Isil Dilek ; Uma Sreenivasan ; Cerilliant Corporation, Round Rock, TX TP 098 Automated Sample Preparation of Whole Blood for Therapeutic Drug Monitoring and Diagnostics by LC- MS using a Commercial Autosampler; Guenter Boehm ; Christian Berchtold ; Götz Schlotterbeck ; Reto Bolliger ; CTC Analytics AG, Zwingen, BL; Fachhochschule Nordwestschweiz Hochschule für Life Sciences, Muttenz, Switzerland; CTC Analytics AG, Zwingen, Switzerland TP 099 Pharmacotherapy Monitoring and Clinical Diagnosis of Patients with APRT Deficiency Utilizing UPLC-MS/ MS Assay; Unnur Arna Thorsteinsdottir, ; Finnur Freyr Eiriksson, ; Hrafnhildur Runolfsdottir ; Vidar Edvardsson ; Runolfur Palsson, ; Margret Thorsteinsdottir, ; University of Iceland, Reykjavik, Iceland; ArcticMass, Reykjavik, Iceland; The National University Hospital of Iceland, Reykjavik, Iceland 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 97

98 GENERAL TUESDAY INFORMATION POSTERS TP 00 TP 0 TP 0 TP 0 TP 04 TP 05 TP 06 TP 07 TP 08 TP 09 TP 0 TP Quantitative Analysis of Steroids in Serum using Ultra High Performance Liquid Chromatography-Tandem Mass spectrometry; Heng-Tao Dong ; Man-Yu Zhang ; Shan-An Chan ; Agilent Technology, Inc. Shanghai, China; Agilent Technology, Inc.Taipei Taiwan, Taiwan Breath and Exhaled Breath Condensate Analyzes for Disease Diagnosis and Monitoring of Newborns by Mass Spectrometry; Vladimir Frankevich ; Vitaliy Chagovets ; Natalia Starodubtseva ; Alexey Kononikhin ; Anna Bugrova ; Andrey Ryndin ; Oleg Ionov ; Gennady Sukhikh ; Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare of the Russian Federation, Moscow, RUSSIA Using Mass Spectrometry to Identify IgG Fc and Fab Fragments Produced by Plasmin in Patient Serum; David Barnidge ; David Murray ; Mayo Clinic / DLMP, Rochester, MN Analysis of Sweat Volatiles using Solid Phase Microextraction in Conjunction with Gas Chromatography Mass Spectrometry; Courtney Weston ; Changling Qiu ; Kevin A. Schug ; The University of Texas, Arlington, TX Exploratory Study of NQO Expression in Advanced Solid Tumors; Yuan Tian ; Fabiola Cecchi ; WEI-LI Liao ; David E. Gerber ; David A. Boothman ; William Hoos ; Todd Hembrough ; Nantomics, Rockville, MD; University of Texas Southwestern Medical Center, Dallas, TX; NQ Oncology, INC, Chapel Hill, NC Quantification of MET by mass spectrometry for status assessment in prescreening of tumors for targeted therapies; Kerry Scott ; Fabiola Cecchi ; Paolo Nuciforo ; Wei-Li Liao ; OncoPlex/NantOmics, Rockville, MD; Vall d Hebron Institute of Oncology, Barcelona, Spain Approach to Implementing LC-MS/MS Plasma Metanephrines : Calibrators, Sample Prep, Workflow; Wai-Yoong Ng ; Jinq Shya Yap ; Janelle SJ Chin ; Chin Pin Yeo ; Singapore General Hospital, Singapore; Singapore General Hospital, Singapore, Singapore Identifications of Candidate Breast Cancer-Specific Biomarkers in Fresh Frozen Breast Tissue Sections by the MALDI-imaging Coupled with On-tissue Digestion; Toyofumi Nakanishi; Osaka Medical College, Takatsuki, Japan Accurate Diagnosis for Prostate Cancer by Measuring the Ratio between Two Types of Prostate Specific Antigens by LDI-TOF MS; Minyoung Yoo; Konkuk University, Seoul, South Korea LDTD-MS/MS Method for Quantitative Analysis of Four Immunosuppressant Drugs in Whole Blood and Cost Analysis Comparison to LC-MS/MS; Stephen D Merrigan ; Matthew Slawson ; Serge Auger ; Kamisha L Johnson- Davis, 4 ; ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT; Utah Public Health Laboratory, Salt Lake City, UT; Phytronix Technologies, Quebec, QC; 4 University of Utah Health Sciences Center, Department of Pathology, Salt Lake City, UT Dried Blood Spots, Water-soluble Material and LC-MS based Protein Analysis; Cecilie Rosting ; Trine Grønhaug Halvorsen ; Astrid Gjelstad ; Christine Østvik Sæ ; School of Pharmacy, University of Oslo, Oslo, Norway The Impact of the Antigen-Antibody Interaction on the Tryptic Digestion in Immunocapture Based LC-MS/ MS; Maren Christin Stillesby Levernæs ; Trine Grønhaug Halvorsen ; Léon Reubsaet ; Marianne Nordlund Broughton ; School of Pharmacy, University of Oslo, Oslo, Norway; Radiumhospitalet, Oslo University Hospital, Oslo, Norway TP Analyte Sequestering Transport Particle Chromatography As A Front-End to Mass Spectrometry; Fred Regnier ; ZhiYu Li ; JinHee Kim ; Purdue University / Novilytic, Carmel, IN; Novilytic, West Lafayette, IN Drug Discovery/DMPK/ADME (Applications) - 9 TP Evaluation of the Pharmacokinetics of a Novel Anti- Diabetic Agent using Conventional LC/MS/MS; Kenji Sugawara, ; Norihide Yokoi ; Ritsuko Hoshikawa ; Toshiya Matsubara ; Susumu Seino ; Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, Kobe, Japan; Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan; Shimadzu Corporation, Kyoto, Japan TP 4 Quantification of Bindings of Organometallic Ruthenium Complexes to Protein Thiols by Mass Spectrometry; Yumiao Han, ; Yu Lin ; Fuyi Wang ; Institute of Chemistry Chinese Academy of Sciences, Beijing, China; University of Pennsylvania, Philadelphia, PA TP 5 Proteome-wide drug dose-response of prostate cancer cell lines exposed to androgen receptor antagonists by microflow-lc SWATH MS analysis; Ludovic Gillet ; Sabine Amon ; Yasuo Uchida ; Nick Morrice ; Christie Hunter ; Ruedi Aebersold, 4 ; ETH Zurich, Zürich, Switzerland; SCIEX, Phoenix House Lakeside Drive Warrington Cheshire UK, WA RX; SCIEX, Redwood City, CA; 4 University of Zurich, Zurich, Switzerland TP 6 Peptide Metabolism: Identification of Metabolite Structures of GLP- Receptor Agonists in Different in vitro Systems Using High Resolution Mass Spectrometry; Andreas Brink ; Alessandra Piranha, ; Yves Siegrist ; Aynur Ekiciler ; Nicola Thum ; Fabien Fontaine 4 ; Ismael Zamora 4 ; Marcel Gubler ; Silke Simon ; Nicole Kratochwil ; Simone Schadt ; Drug Disposition & Safety, Pharmaceutical Sciences, Pharma Research and Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd., Basel, Switzerland; Royal Melbourne Institute of Technology, Melbourne, Australia; School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Basel, Switzerland; 4 Lead Molecular Design, Sant Cugat de Valles, Spain TP 7 Case Study of Stable-Isotopic Dilution for Accurate Mass Spectrometric Pharmacokinetic Quantitation of a Small Intact Protein from in vivo Samples; Phillip Chu ; Xinxin Gao ; Susan Crowell ; Leslie Dickmann ; Rami Hannoush ; Yichin Liu ; John Tran ; Genentech Inc, South San Francisco, CA TP 8 Metabolite Profiling and Covalent Binding of TAK-875 in Human Hepatocytes or Mitochondria; Wing W Lam ; Yong Gong ; Rhys Salter ; Mark R Player ; David C Evans ; Monicah Otieno ; Heng-Keang Lim ; Janssen Research TP 9 TP 0 and Development, Spring House, PA High Resolution Accurate Mass Quantitation of Iloperidone and the Hydroxy Iloperidone Metabolite using Full Scan and Selected Ion Monitoring Modes; David Brant ; Keeley Murphy ; Jonathan L Josephs ; Maciej P Bromirski 4 ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher, San Jose, CA; 4 Thermo Fisher Scientific, Bremen, DE Mechanism and Dynamics of SAMT Analog Inactivation of HIV- Gag Polyprotein; Lisa M. Miller Jenkins ; Elliott L Paine ; Kara M. George Rosenker ; Harichandra D Tagad ; Michael T Scerba ; Lalit Deshmukh ; Daniel H Appella ; National Cancer Institute, NIH Bethesda, MD; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

99 TUESDAY POSTERS TP TP TP TP 4 TP 5 TP 6 TP 7 TP 8 TP 9 TP 0 TP TP Development of a Magnetic Microbead Affinity Selection Screening with UHPLC-MS/MS for the Vitamin D Receptor; Daniel Nosal ; Michael D Rush ; Jerry J White ; Richard B van Breemen ; University of Illinois College of Pharmacy, Chicago, IL Implementation of Mass Spectrometry Ligand Binding (MS bind) Assays to Rapidly Identify Molecules for Radioligand Development for New Drug Targets; Nathan G Hatcher ; Rose B Flick ; James W Monahan ; Gary E Adamson ; Nanyan Rena Zhang ; Charles M Harrell ; Victor N Uebele ; Merck & Co., Inc., West Point, PA Further Efforts towards Accurately Determining Unbound Fractions for Highly Plasma Protein Bound Compounds by LC-MS; Inhou Chu; Merck & Co, Kenilworth, NJ In vitro Hepatic Metabolism of Licochalcone A, a Chalcone from the Licorice species Glycyrrhiza inflata.; Lingyi Huang ; Dejan Nikolic ; Richard B. van Breemen ; University of Illinois College of Pharmacy, Chicago, IL Efficient and Cost-Effective In Vitro Permeability and Transporter Assessment Using the CACOReady 96- well Kit Assay and DiscoveryQuant.0; Jeffrey Clarine ; Katherine Andersen ; Samuel Sperry ; effector Therapeutics, San Diego, CA - California Effects of Intestinal Microbiota on the Bioavailability of Aspirin in Rats; In Sook Kim; Shaheed Ur Rehman; Min Sun Choi; Jong Suk Park; Hyun Kim; Young Seok Ji; Hyeong Jun Kim; So Yeong Yun; Hanyang University, Ansan-si, Gyeonnggi-do A Validated Method for Anatabine Quantification in Human Plasma using High Resolution Parallel Reaction Monitoring Coupled with Chip-Based Nanospray; Jon M Reed, ; Prashanthi Vallabhaneni ; Rosa Ajoy ; Gogce Crynen ; Laila Abdullah ; James E Evans ; Fiona Crawford ; SRQ Bio, Sarasota, FL; Roskamp Institute, Sarasota, FL A Multiplex Assay for Direct Analysis of Natural Products in Crude Botanical Extracts; Geuncheol Gil ; Pan Mao ; Bharathi Avula ; Zulfiqar Ali ; Amar G. Chittiboyina ; Ikhlas A. Khan ; Larry A. Walker ; Daojing Wang ; Newomics Inc., Emeryville, CA; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS Recent Experience on LC-MS/MS Determination of ADC-like Drug Candidates and Corresponding Cytotoxic Agent in Biological Matrices; Xiongfei Wu ; Weimin Hu ; Weiqun Cao ; Yi Tao ; Xinping Fang ; Xin Zhang ; WuXi AppTec Co., Shanghai, China Drug Metabolism: Qualitative and High Throughput Analysis 0-44 Development of an Automated High Throughput PAMPA Experiment for Permeability Assessment of Small Molecules and Peptides; Xu Wang ; Bernard K Choi ; Hui Wan ; Chen Shiying ; Bahanu Habulihaz ; Gino M. Salituro ; Lucinda Cohen ; Merck & Co., Rahway, NJ; Merck, Darmstadt, Germany Emerging Bioanalytical Tool to Characterize Drug and Drug-products of Biotherapeutics; Jinal Patel ; Mark Cancilla ; Xiang Yu ; Alina Dindyal-Popescu ; Gordon Payne ; Eva Duchoslav ; Suma Ramagiri 4 ; SCIEX, Concord, ON; Merck & Co., Inc., West Point, PA; SCIEX, Concord, ON; 4 SCIEX, Concord ON, Canada Improved Data-Independent Workflow Strategies for Small Molecule Identification Using a High Resolution Q-TOF Mass Spectrometer; Alina Dindyal-Popescu ; Keith Goodman ; Eva Duchoslav ; Suma Ramagiri ; SCIEX, Concord, ON; SCIEX, Concord ON, Canada; SCIEX, Concord, ON TP TP 4 TP 5 TP 6 TP 7 TP 8 TP 9 TP 40 TP 4 TP 4 TP 4 A Strategy for the Discovery and Identification of New Natural Product Metabolites by Orbitrap Mass Spectrometer and Multiple Data-Mining Approaches; Chen Li ; Ying Liu ; Jiayu Zhang ; Siyi Liu ; Wei Cai ; Jianqiu Lu ; Thermo Fisher Scientific, Shanghai, China; Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing, China; Hunan University of Medicine, Huaihua, China Peptide Screening using Laser Desorption Ionization Mass Spectrometry on Fluorinated Nanopost Array (NAPA) Devices; Trust Razunguzwa ; Nicholas J Morris ; Heather Anderson ; Matthew J Powell ; Marvin S Yu ; Protea Biosciences, Morgantown, WV; Protea Biosciences, Inc. Morgantown, WV; MS Array LLC, Pittsburgh, PA Metabolic Profiling of Two Novel Topo IIα Catalytic Inhibitors, Fluorescein Hydrazones in rat liver microsomes (RLMs) by LC-MS/MS; Adnan A Kadi ; Nasser S. Al-Shakliah ; Youngjoo Kwon ; A. F. M. Motiur Rahman ; King Saud University, Riyadh-45, Saudi Arabia; Ewha Womans University, Seoul, South Korea Metabolite Profile Comparison using a HμREL Co-culture Hepatocyte Model vs. a Conventional Hepatocyte Suspension for Low Turnover Drugs; J. Matthew Hutzler ; Richard D. Burton ; Xiusheng Miao ; Shelby Anderson ; Todd Hieronymus ; David Heim ; Taysir Chamem ; Q Solutions, Indianapolis, IN Absorption, Distribution and Metabolism of Brodifacoum, a Potent Anticoagulant Rodenticide; Zane Hauck ; Douglas L Feinstein ; Richard B van Breemen ; UIC, Chicago, IL Chiral Separation and Quantification of Metabolites using Super Critical Fluid Chromatography Coupled with Triple Quadrupole; Siji Joseph ; Syed S Lateef ; Agilent technologies, Bangalore, India In-vitro Synthesis of Drug Metabolites and Their Screening/Characterization Using Liquid Chromatography-Mass Spectrometry (LC-MS); Shubhashis Chakrabarty ; Weilin L. L Shelver ; Andrew R. R Thompson ; David J. J Smith ; USDA-Agricultural Research Service, Biosciences Research Laboratory, Fargo, ND Rapid Determination of Pharmacokinetic Profiles of Caffeine and Its Metabolites Collected on Skin by Ambient Mass Spectrometry; Kun-Da Wu ; Hung Su ; Sychyi Cheng ; JENTAIE SHIEA ; National Sun Yat- Sen University, Kaohsiung, TAIWAN Data Robustness of a High-Throughput Autosampler (Apricot Design Dual Arm ADDA) in DiscoveryADME Sample Analysis; Xiaotong Li ; Yunqiang Su ; Chunli Zhu ; YI TAO ; Xinping Fang ; Xin Zhang ; WuXi AppTec Co., Shangha, China; WuXi AppTec Co., Shanghai, CHINA Dual-stream UHPLC Separations on a Compact Sample Delivery System Featuring Simplified Software Automation for Increased Throughput in Drug Discovery Bioanalysis; John Janiszewski, ; Brendon Kapinos ; Wayne Lootsma ; Hui Zhang 4 ; Julie keefer 5 ; Steve Ainley ; Mary Piotrowski 5 ; Pfizer Inc., Groton, CT; Pfizer Worldwide Research and Development, Groton, CT; Sound Analytics, Niantic, CT; 4 Pfizer Worldwide Research and Development, Inc Groton, CT; 5 Pfizer, Groton, CT Determination of Heavy Metal Contamination in DMSO Solutions used for High Throughput Screening; John M. Peltier ; Nicole White ; Melissa Grippo ; Jerome Giovanonni ; Pascal Bernet ; Christian Bergsdorf ; Justin Gu 4 ; Zhaofu Wang 4 ; Adam W Hill ; Novartis Institutes for Biomedical Research, Cambridge, MA; Translational Clinical Oncology, Novartis Institutes for Biomedical Research, Cambridge, MA; Novartis Institutes 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 99

100 GENERAL TUESDAY INFORMATION POSTERS TP 44 of BioMedical Research, Basel, Switzerland; 4 Novartis Institutes of BioMedical Research, Shanghai, China Development of a Higher-throughput Metabolic Soft Spot Assay with Integrated Assessment of Glutathione Adduct Formation; Anthony Paiva ; Wilson Shou ; Cheryl Klakouski ; Tatyana Zvyaga ; Benjamin Johnson ; Yue-Zhong Shu ; Ismael Zamora ; Bristol-Myers Squibb Company, Wallingford, CT; Bristol-Myers Squibb Company, Lawrenceville, NJ; Lead Molecular Design S.L., Sant Cugat de Valles, Spain Energy: Hydrocarbon and Petrochemical (Hi Resolution & Nominal) 45-6 TP 45 Photoionization as a Soft Ionization Source for Comprehensive Two-dimensional GC (GCxGC) and High-Resolution TOFMS; Masaaki Ubukata ; A. John Dane ; Robert B. Cody ; Toshiyuki Kato ; Masahiro Ito ; Bram van der Meer ; Junichi Osuga 4 ; Jean-François Focant 5 ; JEOL USA, Inc., Peabody, MA; JEOL Ltd., Akishima, Japan; JEOL Europe B. V., Zaventem, Belgium; 4 JEOL Europe SAS, Croissy-Sur-Seine, France; 5 University of Liège, Liège, Belgium TP 46 Investigation of the Partial Oxidation of Propane using a jet-stirred Reactor and Molecular-Beam Mass Spectrometry; Dennis Kaczmarek ; Patrick Oßwald ; Dominik Krüger ; Markus Köhler ; Tina Kasper ; University of Duisburg-Essen, Duisburg, Germany; Institute of Combustion Technology, German Aerospace Center, Stuttgart, Germany TP 47 Changing the Paradigm in Petroleomics with Comprehensive Two-Dimensional Gas Chromatography- High Resolution Mass Spectrometry; Joe Binkley ; Jonathan D Byer ; David E Alonso ; Lorne Fell ; LECO Corporation, Saint Joseph, MI TP 48 Analysis of Petroleum Products using Comprehensive Two-Dimensional Gas Chromatography (GC GC) with Both Time of Flight MS and Flame Ionization Detectors; Christina Kelly ; Joseph E Binkley ; Lorne E Fell ; Jonathan D Byer ; David E Alonso ; LECO Corporation, Saint Joseph, MI TP 49 TP 50 TP 5 TP 5 A New Method for Characterizing Heavy Petrochemical Fractions Based on Thermal Analysis and Laser Photo Ionization Mass Spectrometry; Ralf Zimmermann ; Anne Ulbrich ; Thorsten Streibel ; Mohammad Saraji-Bozorgzad 4 ; Sebastian Wohlfahrt ; Michael Fischer ; Thomas Denner 5 ; Christoph Grimmer ; University of Rostock, Rostock; University of Rostock, Rostock, N/A; University of Rostock, Rostock, Germany; 4 Photonion GmbH, Schwerin, Germany; 5 Netzsch Gerätebau GmbH, Selb, Germany Identification of the Byproducts in the Preparation of,6-naphthalenedicarboxylic Acid by UPLC-QTOF MS/ MS; Jiwen Li ; Liyan Jiang ; Junyan Liu ; Chuan Wang ; SINOPEC SRIPT, Shanghai, Shanghai; Sinopec Shanghai Research Institute of Petrochemic, Shanghai, China High Performance Thin Layer Chromatography (HPTLC) Coupled with DESI-Ion Mobility-Mass Spectrometry: A Novel Approach for Petroleum Characterisation; Eleanor Riches ; Caroline Mangote ; Delphine Thuault ; Pierre Giusti ; Carlos Afonso ; Peter Hancock ; Waters Corporation, Wilmslow, United Kingdom; TOTAL Refining & Chemicals, Total Research & Technology Gonfreville,, F Harfleur, France; Normandie Univ, COBRA, UMR604 and FR08,Université de Rouen; INSA de Rouen; CNRS, IRCOF,, Rouen, France Intrinsic Ion Mobility Peak Width as an Indicator of Isomeric Species Distribution in Petroleum using Ion Mobility - Mass Spectrometry; Mathilde Farenc,, ; Eleanor Riches 4 ; Carlos Afonso, ; Pierre Giusti, ; TOTAL Refining and Chemicals, TRTG Gonfreville l Orcher, TP 5 TP 54 TP 55 TP 56 TP 57 TP 58 TP 59 TP 60 TP 6 TP 6 TP 6 France; Normandie Univ, CNRS UMR 604 COBRA Mont St Aignan, France; TOTAL RC - CNRS Joint Laboratory CMC :Complex Matrices Molecular Characterization, -, France; 4 Waters, Wilmslow, United Kingdom Petroleomics by Atmospheric Solid Analysis Probe Mass Spectrometry (ASAP-MS); Lilian Tose ; Michael Murgu ; Boniek Gontijo Vaz ; Wanderson Romão ; UFES, Vitória, Brazil; waters Corporation, São Paulo, BRAZIL; UFG, Goiânia, Brazil Application of Paper Spray Ionization Mass Spectrometry for the Analysis of Weathered Oil; Donghwi Kim ; Purum Kim ; Joon Geon An ; Un Hyuk Yim ; Sangwon Cha ; Sunghwan Kim ; Kyungpook National University, Daegu, Republic of Korea; Hankuk Univ. Foreign Studies, Yongin, South Korea; Korea Institute of Ocean Science and Technology, Geoje, South Korea UnisprayTM Ion Source Coupled to UHPSFC for the Detection of Oilfield Additives; Efstathios Andreas Elia ; William Durnie ; Ed Sparke ; John G Langley ; Chemistry, University of Southampton, Southampton, United Kingdom; BP Exploration, Sunbury-on-Thames, Middlesex, United Kingdom; Waters, Wilmslow, United Kingdom Insights into Iron Promoted Sugar Conversion to 5-Hydroxymethylfurfural (HMF) and Levulinic Acid (LA) From Tandem Mass Spectrometry; Yuan Jiang ; Linan Yang ; Christine M Bohn ; Guannan Li ; Dong Han ; Nathan S Mosier ; Jeffrey T Miller ; Hilkka I Kenttämaa ; Mahdi M Abu-Omar ; Purdue University, West Lafayette, IN Untargeted Metabolomic Approach for the Management of Microbiologically Influenced Corrosion in the Oil and Gas Industry; Vincent Bonifay ; Iwona B Beech ; Jan A Sunner ; University of Oklahoma, Norman, OK A Fast Mass Spectrometric Approach for the Characterization of Aromatic Compounds Present in Crude oil; Ravikiran Yerabolu ; Raghavendhar Kotha ; Xueming Dong ; John Kong ; Bryan Clayton ; Hilkka Kenttämaa ; Purdue University-Department of Chemistry, West Lafayette, IN; Pioneer Oil Company, Lawrenceville, IL GC-MS and SFC-MS Approaches for the Low level Detection and Quantification of a New Fuel Marker; John G Langley ; Julie M Herniman ; Edward M. J. Wilmot ; Anastarsia C. M. Carter ; Jim Barker, ; University of Southampton, Southampton, United Kingdom; Innospec Inc., Ellesmere Port, United Kingdom; Energy Institute, London, United Kingdom Comparison of GC-MS, GC-VUV, and Comprehensive Two-Dimensional GC for the Characterization and Source Identification of Diesel Fuels; Ling Bai; University of Texas at Arlington, Arlington, Texas Using GC/MSD with High Efficiency Source and Hydrogen Cleaning to Detect Low Level Contaminants in Ethylene and Propylene; Angela Henry ; Bruce Quimby ; Badr Astiphan ; Agilent Technologies, Little Falls, DE; Agilent Technologies, Santa Clara, CA Can Elusive Structural Features of Heavy Crude Oil Components be Decoded from FT-ICR-MS Data?; Cristian Blanco-Tirado ; Marianny Y Combariza ; Cristian Alejandro Blanco-Combariza ; Universidad Industrial de Santander, Bucaramanga, Santander; Universidad Industrial de Santander, Bucaramanga, Santander, Colombia Highly Specific Biomarker Determination in Biodegraded Petroleum with Gas Chromatography and Triple Quadrupole Detection using Multiple Reaction Monitoring; Andrés González ; Taylor Motta ; Ivama Calles ; Sánchez Carlos ; Jairo René Martínez ; Stashenko Elena ; Universidad Industrial de Santander, Bucaramanga, Santander, Colombia PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

101 TUESDAY POSTERS Environmental Analysis: General (Part ) TP 64 Rapid Exploration of the Mechanism of Action of Forskolin via Untargeted Proteomics and Knowledgebased Pathway Analysis; Ziad Sahab ; Bindesh Shrestha ; Lida Parvin ; Peter Nemes ; Akos Vertes ; George Washington University, Washington, DC; Waters Corporation, Beverly, MA TP 65 Determination ff Aqueous Film Forming Foam (AFFF) Components using a Multivariate Analysis Approach; Lauren Mullin ; Anna Karmann ; Gareth Cleland ; John Vukovic ; Adam Ladak ; Waters, Milford, MA; MTM Research Centre, Örebro University Örebro, Sweden TP 66 Characterization of Fe-rich Multi-element Particles by ICP TOF; Joel Kimmel ; Olga Borovinskaya ; Martin Tanner ; TOFWERK, Thun, Switzerland TP 67 Polycyclic Aromatic Hydrocarbon and Metabolite Analysis of Soils Related to Energy Exploration by On-Line SFE/SFC-MS; Doug D. Carlton, ; A. Paige Wicker ; Kenichiro Tanaka ; Erin McAllister ; Kevin A Schug, ; Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX; Affiliate of the Collaborative Laboratories for Environmental Analysis and Remediation, The University of Texas at Arlington, Arlington, TX; Shimadzu Scientific Instruments, Inc., Columbia, MD TP 68 Laser DesorptionSingle Particle Aerosol Mass SpectrometryforDirectAnalysis of Solid Materials; Mei Liu ; Li Xu ; Junguo Dong ; Zhengxu Huang ; Ping Cheng ; Zhen Zhou ; School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China; Institute of Atmosphere environment security and Pollution control, Jinan University, GuangZhou, China; School of Environmental and Chemical Engineering, Shanghai University, Shanghai, Shanghai TP 69 Development and Validation of a UPLC-MS/MS Method for Mono(-ethylhexyl)phthalate, a Metabolite of Di(- ethylhexyl)phthalate, in Rat Plasma, Amniotic Fluid, and Fetus; Melanie A. Rehder Silinski ; Brenda L. Fletcher ; Reshan A. Fernando ; Veronica G. Robinson ; Paul Foster ; Suramya Waidyanatha ; RTI International, Research Triangle Park, NC; RTI International, Research Triangle Park, NC; Division of National Toxicology Program, NIEHS, Research Triangle Park, NC TP 70 An Automated Method for Microcystins Analysis using Two-dimensional Liquid Chromatography-quadrupole Time-of-Flight Mass Spectrometry (DLC-QTOFMS); Xavier Ortiz Almirall ; Marie Meyer-Monath ; Eva Korenkova ; Karl Jobst ; Eric Reiner ; Karen MacPherson ; Ministry of the Environment and Climate Change of Ontario, Toronto, ON; University of Toronto, Toronto ON, Canada TP 7 Development of an LC-QTOF MS Method for the Non-targeted Analysis of Microcystins; Marie Meyer- Monath, ; Xavier Ortiz ; Eva Korenkova ; Ralph Ruffolo ; Karl Jobst, ; Satyendra Bhavsar,, 4 ; Andre Simpson ; Eric Reiner, ; Ontario Ministry of Environment & Climate Change, Toronto, Canada; University of Toronto, Toronto ON, Canada; McMaster University, Hamilton, Canada; 4 University of Windsor, Windsor, Canada TP 7 Determination of Trace Microcystins in Aqueous Samples by Solid-Supported Liquid Extraction Coupled to Liquid Chromatography-Tandem Mass Spectrometry; Chang-Lin Hsu ; Chung-Yu Chen ; Maw-Rong Lee ; National Chung-Hsing University, Taichung, TAIWAN (R.O.C.); National Chung-Hsing University, Taichung, Taichung TP 7 TP 74 TP 75 TP 76 TP 77 TP 78 TP 79 TP 80 TP 8 TP 8 TP 8 TP 84 Effect of Analytical Standard Preparation Procedures in the Quantitation of Urinary Monohydroxy-Polycyclic Aromatic Hydrocarbons (OH-PAHs) by Online SPE- HPLC-MS/MS; Yuesong Wang ; Lei Meng ; Erin N Pittman ; Alisha Etheredge ; Kendra Hubbard ; Debra A Trinidad ; Xiaoyun Ye ; Antonia M. Calafat ; CDC, Atlanta, GA New,4-dinitroanisole (DNAN; Munitions Chemical) (bio)transformation Products discovered and Bioassayed using High Resolution UPLC-QToFMS; Leif Abrell ; Christopher I. Olivares ; Jon Chorover ; Reyes Sierra-Alvarez ; Jim A. Field ; University of Arizona, Tucson, Arizona Investigation of Eicosanoids and Fatty Acids in Pansteatitis-Affected Mozambique Tilapia at Loskop Dam, South Africa; theresa cantu ; John Bowden ; Jack McAlhany ; Matthew Guillette 4 ; hannes botha 5 ; Louis J. Guillette 4 ; MUSC, Charleston, SC; National Institute of Standards and Technology, Charleston, SC; college of charleston, charleston, sc; 4 Medical Univ of S Carolina, Charleston, SC; 5 Mpumalanga Tourism and Parks, Pretoria, South Africa Analysis of Problematic Cyclic Siloxane Compounds in the Atmosphere of the International Space Station; Patti Cheng ; Vanessa de Vera ; Robert Gillispie ; Steven Beck ; William Wallace ; Thomas Limero ; Wyle Science, Technology, and Engineering Group, Houston, TX;, Houston, TX Accurate Mass Spectral Database: Harnessing the Power of High Performance Mass Spectrometry at Long Last; Lorne Fell ; Viatcheslav Artaev ; Kevin McNitt ; Steve Robles ; Albert Lebedev ; LECO Corporation, Saint Joseph, MI; Moscow State University, Moscow, Russian Federation A Method for Real-Time Monitoring of Acrolein in Air using TAGA Mass Spectrometry; Nicholas Karellas; Ontario Ministry of the Environment, Toronto, ON Mass Spectrometry-based Studies on the Association of Organic Dusts and Respiratory Symptoms; Brooke Thompson ; Paulos Chumala ; Shelley Kirychuk ; George S. Katselis ; CCHSA/Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada Monitoring Fugitive Emissions with a Miniature Ion Trap Mass Spectrometer; Preshious Rearden ; Corey Stedwell ; Parminder Kaur ; Daniel DeBord ; st Detect Corporation, Webster, TX Analytical Strategy to Investigate Naphthenic Acids in Atmospheric Aerosols by Ultrahigh-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry (UPLC/QTOF-MS); Mahmoud Yassine; Environment and Climate Change Canada, Ottawa, ON A Comparison of Thermal- and Valve-based Modulation for the Analysis of Environmental Contaminants by GCxGC-TOF MS; Tadeusz Gorecki ; Matthew Edwards, ; Haleigh Boswell ; Pete Grosshans ; University of Waterloo, Ontario, Canada; Markes International, Cardiff, UK; Markes International Inc, Cincinnati, OH High sensitive quantitation method of perfluorinated compounds by an automated online solid extraction LC/MS/MS; Yoshikane Mitsuha ; Jun Watanabe ; Kagi Noriko ; Minohata Toshikazu 4 ; Ogura Tairo 5 ; Nakayama Shoji 6 ; IDEA Consultants, Inc., Yaidzu, Japan; Shimadzu Corporation, Kyoto; JASCO International Co., Ltd., Hachioji, Japan; 4 Shimadzu Corporation, Kyoto, Japan; 5 Shimadzu Scientific Instruments, Inc. Columbia.; 6 National Institute for Environmental Studies, Tsukuba, Japan A Collaborative EPA Method 65 Update Study using a New Mass Spectrometry Method for Quantification Combined with Stir-bar Sorptive Extraction; Weier Hao ; Andrew Boggess ; Edward Pfannkoch ; Skip Kingston ; Duquesne University, Pittsburgh, PA; Gerstel, Inc. Linthicum, MD 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 0

102 GENERAL TUESDAY INFORMATION POSTERS TP 85 TP 86 TP 87 TP 88 TP 89 TP 90 TP 9 TP 9 TP 9 TP 94 TP 95 TP 96 TP 97 TP 98 Automated Screening of Explosives in Soil Samples by Online SFE-SFC-MS; William A Hedgepeth ; Kenichiro Tanaka ; Tairo Ogura ; Jonathan Edwardsen ; Shimadzu Scientific Instruments, Inc, Columbia, MD; Shimadzu Scientific Instruments, Inc. Columbia, MD Efficiency Screening of Carbon Nanomaterial or Superoxydant in Advanced Water Treatment by Mass Spectrometry Are They Accurate Enough?; Hugues Preud homme ; Jaber Al-Marri ; Pierre Kubiak ; Rachid Essehli ; QEERI - HBKU - Qatar Foundation, Doha, QATAR Chromatographic Mass Spectrometric Detection of Arsenic Species in Sulfidic Waters Method Development; Denzel Bolden ; Akeena Harper ; Jianye Zhang ; Voorhees College, Denmark, SC Fast Detection of Environmental Vapors by Thermal Desorption - Atmospheric Pressure Photoionization - Differential Mobility Analysis - Mass Spectrometry (TD- APPI-DMA-MS); Ross David McCulloch ; Amo González Mario ; SEADM, Boecillo, Spain FAIMS and DMS Rapid Separation and Quantification of Hydroxyvitamin D Epimers by FAIMS-MS, Eliminating the Need for LC Separation for High-throughput Clinical Analysis; Lauren Brown ; Danielle Toutoungi ; Robert Smith ; Billy Boyle ; Owlstone Ltd., Cambridge, UK Resolution of Isotopologues and Isotopomers by High- Field Ion Mobility Coupled to Mass Spectrometry: Path to Gas-Phase NMR?; Julia Kaszycki ; Matthew A. Baird ; Andrew P. Bowman ; Alexandre A Shvartsburg ; Wichita State University, Wichita, KS Modeling and Characterization of the Ion Transit Time in a FAIMS-MS Interface; Satendra Prasad ; Jean-Jacques Dunyach ; Michael W Belford ; Thermo Fisher Scientific, San Jose, CA On a Multi-physics Computational Model to Understand Heat Exchange between FAIMS Electrode and Ion Transport Gas; Satendra Prasad; Thermo Fisher Scientific, San Jose, CA Efficiency of Ion Transmission between FAIMS Electrodes without a Separation Electric Field; Satendra Prasad ; Susan E Abbatiello ; Michael W Belford ; Jean- Jacques Dunyach ; Mary L Blackburn ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Cambridge, USA Comparison of Rectangular Waveform FAIMS/MS to Conventional Sum-of-sines Waveform; Michael Wei ; Michael Costanzo ; Joaquin Casanova ; Jared Boock ; Richard A Yost ; University of Florida, Gainesville, Florida Glyphosate quantified in Black Tea and Other Food Matrices by Automatically Optimized LC-FAIMS MS/ MS; Bennett Kalafut ; Rae Ana Snyder ; Claudia Martins ; Manish Doshi ; Mark Hardman ; Thermo Fisher Scientific, San Jose, California Rapid FAIMS at Extreme Fields Inside the Mass Spectrometry Envelope with Applications to Peptide and Protein Analyses; Alexandre Shvartsburg ; Andrew Entwistle ; Roger Giles ; Wichita State University, Wichita, KS; Shimadzu Research Laboratory (Europe) Ltd., Manchester, United Kingdom Is Differential Mobility Chemically Driven? Evidence and Simulations for Chemical Effects as Primary Separation Factor in DMS; Walter Wissdorf ; Bradley B Schneider ; Tom Covey ; James Hager ; Thorsten Benter ; Bergische Universität Wuppertal, Wuppertal; SCIEX, Concord, ON; Bergische Universität Wuppertal, Wuppertal, Germany LESA FAIMS Mass Spectrometry for the Spatial Profiling of Proteins from Tissue; Rian L. Griffiths ; Alex Dexter ; Andrew J Creese ; Alan M. Race ; Josephine Bunch, ; Helen Cooper ; University of Birmingham, Birmingham, UK; National Physical Laboratory, Teddington, UK; University of Nottingham, Nottingham, UK TP 99 Analysis of Derivatized Glycans using Differential Mobility Spectrometry; Cathy Lane ; Yves J C LeBlanc ; J. Larry Campbell ; SCIEX, Phoenix House Lakeside Drive Warrington Cheshire UK, WA RX; SCIEX, Concord, ON TP 00 Improved Quantitative Measurements for Large Scale Proteomic Analyses using Metabolic Labeling and Ion Mobility; Sibylle Pfammatter ; Eric Bonneil ; Pierre Thibault ; IRIC-Université de Montréal, Montréal, QC; Universite de montreal, Montreal, QC TP 0 Model FAIMS RF System using Neural Network; Xiaoqun Zou; Thermofisher Scientific, San Jose, CA TP 0 Making FAIMS Faster, More Selective, and More Sensitive; Michael Belford ; Satendra Prasad ; Jean- Jacques Dunyach ; Susan E Abbatiello ; Ryan Hermezian ; Hoa Pham ; Ann Yadlowsky ; Alex Zou ; Thermo Fisher Scientific, San Jose, CA TP 0 SelexIon-based Detergent Interference Removal for Shotgun-Lipidomics Analyses; Cyrus Papan ; Julian D Langer ; Sciex, Darmstadt, Hessen; Max-Planck-Institute of Biophysics, Frankfurt Am Main, Germany TP 04 Rapid Analysis of Steroid Metabolites using Field Asymmetric Waveform Ion Mobility Spectrometry Combined with Liquid Chromatography and Mass Spectrometry; Kayleigh Louise Arthur ; Matthew Arran Turner ; James Christopher Reynolds ; Colin Creaser ; Loughborough University, Loughborough, United Kingdom TP 05 Differential Mobility Spectrometry (DMS) Reveals the Elevation of Urinary Acetylcarnitine in Non-Human Primates (NHP) Exposed to Radiation; Nicholas B. Vera, ; Amol Kafle ; Evan Pannkuk 4 ; Evagelia C. Laiakis 4 ; A.J. Fornace, Jr. 4 ; Stephen L. Coy ; Derek M Erion ; Paul Vouros ; Pfizer, Cambridge, MA; Northeastern University, Boston, Massachusetts; Northeastern University, Boston, MA; 4 Georgetown University, Washington, DC TP 06 Characterization of Variables Affecting Internal Energy Deposition inside a Differential Ion Mobility Spectrometer; Brandon Santiago ; Matthew T. Campbell ; Gary L. Glish ; The University of North Carolina at Chapel Hill, Chapel Hill, NC TP 07 Analysis of Free Drug in Antibody-Drug Conjugate by Reversed-phase HPLC Coupled with Differential Mobility Mass Spectrometry; Chunang (Christine) Gu ; Marie-France Morissette ; Loren Y Olson ; Shaokun Pang ; Yi Li ; Colin Medley ; David Russell ; Genentech, South San Francisco, CA; Genentech Inc, South San Francisco, CA; SCIEX, Redwood City, CA TP 08 Optimizing DMS Separations by Comparing Alpha Functions; Brad Schneider ; Erkinjon Nazarov ; J.C. Yves Le Blanc ; Frank Londry ; Thomas Covey ; SCIEX, Concord ON, Canada TP 09 Rapid Ion Trap Mass Analysis of Inorganic Water Clusters Separated by Differential Mobility Spectrometry; Theresa Evans-Nguyen ; Timothy Vazquez ; University of South Florida, Tampa, FL Food Safety (Pesticides in Food) 0-5 TP 0 Significant Improvement in GCMS Screening of Pesticides in Scan Mode using a High Efficiency Ion Source and Spectral Deconvolution; Melissa Churley ; Bruce Quimby ; Agilent Technologies, Santa Clara, CA; Agilent Technologies, Little Falls, DE TP A Targeted Quantitative LC-MS/MS Method for 4 Positive and Negative Ion Pesticides in a Single Analysis; Louis Maljers ; Zicheng Yang ; Bruker Daltonics, Fremont, CA; Bruker Daltonics Inc, Fremont, CA PAGE 0 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

103 TUESDAY POSTERS TP TP TP 4 TP 5 TP 6 TP 7 TP 8 TP 9 TP 0 TP TP TP TP 4 GC/MS/MS Analysis of Pesticide Residues in Cannabis Using QuEChERS Extraction and Cleanup; Kathy Stenerson ; Craig Aurand ; David Bell ; Sara Smith ; Emily Barrey ; Candace Price ; MilliporeSigma, Bellefonte, PA Analysis of Pesticides in Spaghetti Sauce by Direct Immersion Solid Phase Microextraction GC/MS; Kathy Stenerson ; Candace Price ; Craig Aurand ; Dave Bell ; Emily Barrey ; Sara Smith ; Sigma Aldrich, Bellefonte, PA An Optimal Method for the Analysis of Pesticides in a Variety of Matrices; Jessica Westland ; Vivian Chen ; Agilent Technologies, Wilmington, Delaware; AGILENT, Shanghai, China Accurately Identify and Quantify A Hundred Pesticides in a Single GC Run; Jessica Westland ; Tom Doherty ; Vivian Chen ; Agilent Technologies, Wilmington, Delaware; Agilent Technologies, Santa Clara, CA; Agilent, Shanghai, China Maintaining Sensitivity and Reproducibility with the Self Cleaning Ion Source for Pesticides in Food and Feed; Vivian Chen ; Jessica Westland ; Elizabeth Almasi ; Agilent, Shanghai, China; Agilent Technologies, Wilmington, Delaware; Agilent Technologies, Santa Clara, CA No Dilute Just Shoot LC-ESI-MS/MS : Feasibility and Robustness of a Maintenance-Free Source for Applications in Low-level Pesticide Residue Analysis; Matteo Meglioli ; Frank A Kero ; Joshua Ye ; Craig Young ; Sharanya Reddy ; Mosti Mondiale, Villa Ste Catherine, QC; PerkinElmer, Shelton, CT; Ionics Mass Spectrometry Group, Bolton, ON Rapid Detection of Pesticides in Honey by C8 Pipettetip Electrospray Ionization Mass Spectrometry; Yi- Ching Choi ; Tsz-Tsun Ng ; Bin Hu ; Zhong-Ping Yao ; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China A Single LC-MS/MS Method for Confirmation and Quantification of over 400 Pesticides in Complex Matrix without Compromising Data Quality; Dimple Shah ; Eimear McCall ; Gareth Cleland ; Waters Corp., Milford, MA; Waters, Wilmslow, United Kingdom; Waters Coorporation, Milford, MA Determination of Multiple Pesticides Residues in Imported Tea in UAE Using Liquid and Gas Chromatography Tandem Mass Spectrometry; Mohammed Meetani ; Sarah Ali Almulla, ; Nasra M. Ibrahim ; United Arab Emirates University, Al-Ain, Abu Dhabi; laboratories Department, Ministry of Environment and Water, Sharjeh, United Arab Emirates; chemistry Department, College of Science, UAE University, Al-Ain, United Arab Emirates Multi-residue Analysis of Pesticides in Agricultural Products using QuEChERS and SFC/MS; Yuka Fujito ; Kenichiro Tanaka ; Tairo Ogura ; Kiyomi Arakawa ; Yoshihiro Hayakawa ; Shimadzu Corporation, Kyoto, Japan; Shimadzu Scientific Instruments, Inc. Columbia Supercritical Fluid Chromatography/Tandem Mass Spectrometry (SFC-MS/MS) Analysis of Hundreds of Pesticide Residues in Food Safety; David Baker ; Christopher Titman ; Jonathan Horner ; Neil Loftus ; Shimadzu, Manchester, UK; SAL (Scientific Analysis Laboratories), Cambridge, UK Quantitative Analysis of 647 Pesticides (,99 MRMs) by LC-MS/MS with a Fast 0.5 Minute Cycle Time; David Baker ; Laetitia Fages ; Eric Capodanno ; Neil Loftus ; Simon Ashton ; Shimadzu, Manchester, UK; Phytocontrol, Nimes, France Food Residue Screening using Liquid Chromatography Coupled to High Resolution MS/MS (LC-HR-MS/MS) - Multi-Pesticide Identification and Quantitation; KC Hyland ; Paul Winkler ; Andre Schreiber ; SCIEX, Redwood City, CA; AB SCIEX, Concord, ON TP 5 Screening of Pesticides in Lipid-rich Food Matrices by using High Resolution GC/Q-TOF and Accurate Mass Pesticide Library; Kai Chen ; Joan Stevens ; Hong Chen ; Vadim Kalmeyer ; Sofia Nieto ; Agilent Technologies, Santa Clara, CA; Agilent Technologies, Wilmington, DE TP 6 Routine Quantitative and Qualitative Methodologies for Food Pesticide Residue Laboratories Using Tandem and High Resolution Accurate Mass (HRAM) LC/MS Instrumentation; Claudia Martins ; Ed George ; Dipankar Ghosh ; Katerina Bousova ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Dreieich, Germany TP 7 Screening for More than 600 Pesticide Residues and Their Identification in Food Samples using a New LCMSMS Library Data Base; Houssain El Aribi ; Salah A. Almaiman ; Mustafa A. Gassem ; Majed A. Alansari ; Saudi FDA, Riyadh TP 8 Rapid Extraction and Clean-up Kits for the Determination of Pesticide Residues in Food; Shao Kai Lin; Taichung, Taichung TP 9 Development of Multi-Pesticides in Avocado using Enhanced Matrix Removal by liquid Chromatography- Tandem Mass Spectrometry with Dynamic MRM and Triggered MRM; Wen-Yen Lee ; Jin-Lan Sun ; Chun-Ye Sun ; Shan-An Chan ; Agilent, Taipei, Taiwan; Agilent, Shanghai, China TP 0 Rapid Screening and Quantitation of Pesticide Residues in Cannabis by Modified QuEChERS and LC-MS-MS; Jeff Dahl ; Julie Kowalski ; Gordon Fagras ; Shimadzu, Columbia, MD; Restek Corporation, Bellefonte, PA; Trace Analytics, Spokane, WA TP Pesticide Analysis in Complex Food Extracts by Multitransition MRM and Library Searching for Enhanced Residue Confirmation; David Baker ; Christopher Titman ; Jonathan Horner ; Neil Loftus ; Shimadzu, Manchester, UK; SAL (Scientific Analysis Laboratories), Manchester, UK TP Fast Data Acquisition Speed and High quantitative Performance in the Simultaneous Determination of Mycotoxins, Illegal Dyes and Pesticides in Spices; Mark Sartain ; Thomas Glauner ; Craig Marvin ; Andre Santos 4 ; Anumol Tarun ; Jerry Zweigenbaum ; Agilent Technologies, Santa Clara, CA; Agilent Technologies Sales & Services GmbH, Waldbronn, Germany; Agilent Technologies, Wilmington, DE; 4 Agilent Technologies Inc, Barueri, Brazil TP Multi-Residue Pesticides Analysis by LC-MS/MS using the ODS Column and the Biphenyl Column; Natsuyo Asano ; David Baker ; Yuki Uno ; Atsuhiko Toyama ; Jun Watanabe ; Shimadzu Corporation, Kyoto, Japan; Shimadzu, Manchester, UK TP 4 Automated Pressurized Liquid Extraction and Clean Up of Sea Food Samples in the Analysis of Persistent Organic Pollutants (POPs); Hamid Shirkhan ; Rudolf Addink ; Toxic Report, Watertown, MA TP 5 Fully Automated Online Sample Extraction and Analysis of Mycotoxins in Foods by Online SFE-SFC- MS; Kenichiro Tanaka ; William Hedgepeth ; Tairo Ogura ; Shimadzu Scientific Instruments, Inc. Columbia Food omics MS Characterization of Food and Nutritional Supplements (Part ) 6-50 TP 6 DLLME-Gas Chromatography-Quadrupole Timeof-Flight Mass Spectrometry for Classification of Botanical Origin of Chinese Honey by Its Volatile and Semi-volatile Compound Profile; Hui Chen ; Linghe Jin ; Chunlin Fan ; Guofang Pang ; Shan Zhou ; Wenwen Wang ; Chinese Academy of Inspection and Quarantine, Beijing, China; Shandong Agriculture University, Tai an, China; Agilent Technologies Company. Ltd, Beijing, China 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 0

104 GENERAL TUESDAY INFORMATION POSTERS TP 7 TP 8 TP 9 TP 40 TP 4 TP 4 TP 4 TP 44 TP 45 TP 46 TP 47 TP 48 Discrimination of Honey of Different Botanical Origins using an Untargeted High-Definition Metabolomic Workflow; Joanne B. Connolly ; Sara Stead ; Antonietta Wallace ; Delano Turner ; Waters Corporation, Manchester, UK; Waters Corporation, Manchester, UK Proteomic and Peptidomic Differences and Similarities between Four Muscle Types from New Zealand Raised Angus Steers; Stefan Clerens, ; Ancy Thomas ; Jessica Gathercole ; Jeffrey E Plowman ; Tzer-Yang Yu ; Anita J Grosvenor ; Stephen R Haines ; Peter Dobbie ; Kevin Taukiri ; Katja Rosenvold ; Jolon M Dyer ; Santanu Deb-Choudhury ; AgResearch, Lincoln, New Zealand; Biomolecular Interaction Centre, Christchurch, New Zealand; AgResearch, Ruakura, New Zealand The Modernisation of Fish Fraud Detection using Rapid Evaporative Ionisation Mass Spectrometry (REIMS); Connor Black ; Olivier Chevallier ; Julia Balog ; Sara Stead ; Steven D Pringle 4 ; Christopher Elliott ; Zoltan Takats 5 ; Queens University Belfast, Balfast, UK; Waters WRC, Budapest, Hungary; Waters corp, Manchester, Lanc; 4 Waters, Wilmslow, United Kingdom; 5 Imperial College, London, United Kingdom Solid Phase Mesh Enhanced Sorption from Headspace (SPMESH) Coupled to DART-MS/MS for Quantification of Trace-level Odor-active Volatiles in Foodstuffs; Jillian Jastrzembski; Cornell University, Ithaca, New York Headspace Analysis of E-Cigarette Liquid Flavorings by Vacuum Thermal Desorption; Eric Knappenberger ; Corey Stedwell ; J. Daniel DeBord ; st Detect, Webster, TX Direct Analysis of Anthocyanins (a Class of Flavonoid Antioxidants) in Complex Plant Extracts; Chad C Nelson ; Douglas Stevenson ; Nu Skin Enterprises, Provo, UT Matrix Effects Limit Accuracy in SPME-GC-MS Analyses of a Grape Mapping Population; Elizabeth A. Burzynski ; Imelda Ryona ; Bruce I. Reisch ; Gavin L. Sacks ; Cornell University, Ithaca, NY; Q Solutions, Ithaca, NY HILIC Chromatography Coupled with IMS/MS for Characterization of Phenolic Compounds and Related Pigments in Red Wine ; Andre De Villiers ; Andrew Baker ; Department of Chemistry and Polymer Science, Stellenbosch University, Matieland, South Africa; Waters, Inc., Pleasanton, CA Analysis of Pinot Noir Wines by HS-SPME GC/Q-TOF: Correlating Geographical Origin with Volatile Aroma Profiles; Philip L. Wylie ; Anna K. Hjelmeland ; Ron C. Runnebaum ; Susan E. Ebeler ; Agilent Technologies, Wilmington, DE; University of California-Davis, Davis, CA Discrimination of Wine Cultivars and Geographic Origins by Characteristic Components Profiling using UHPLC-ESI/QTOF-MS Combined with Chemometric Analysis; Nana Liang ; Ying Liu ; Meiling Lu ; Shan Zhou ; Jinhua Wang ; Zhaohui Zhang ; Shen Han ; Beijing Entry- Exit Bureau of Inspection and Quarantine, Beijing, China; Agilent Technologies (China) Limited, Beijing; Agilent Technologies (China) Limited, Beijing, China Unravelling the Color of a Worldwide Rosé Wine Collection by UHPLC-MRM-MS Polyphenol Profiling; Nicolas Sommerer ; Marine Lambert ; Arnaud Verbaere ; Emmanuelle Meudec ; Marie-Agnès Ducasse ; Jean-Claude Boulet ; Gérard Mazerolles ; Gilles Masson ; Véronique Cheynier ; INRA, UMR08 SPO, Montpellier, France; IFV, UMT QUALINNOV, Gruissan, France; IFV, centre du rosé, Vidauban, France LC/MS Metabolomic Profiling of an Amber Ale Fermented with Four Different Yeast Strains; Kearney M Foss ; Karen Fortmann ; Christine A. Hughey ; James Madison University, Harrisonburg, VA; White Labs, San Diego, CA; James Madison University, Harrisonburg, VA TP 49 TP 50 TP 5 TP 5 TP 5 TP 54 TP 55 TP 56 TP 57 TP 58 TP 59 TP 60 TP 6 TP 6 Rapid Preparation for Quantitative Analysis of Volatile and Semi-Volatile Compounds in Scotch Using Gas Chromatography Mass Spectrometry; Yashaswini Nagarajan ; Doug D Carlton ; Evelyn H Wang ; Jillian Melbourne ; Kevin A Schug ; Department of Chemistry and Biochemistry, UTA Arlington, tx Analysis of the Oligosaccharide and Protein Content of Beer Using Matrix-Assisted Laser Desorption Ionization Time-Of-Flight Mass Spectrometry (MALDI TOFMS); Elsa Gorre ; Ashley Phetsanthad ; Jon Soffer ; Kevin G Owens ; Drexel University, Philadelphia, PA Forensics (Part ) 5-78 Cryogenic-Focusing Fast Gas Chromatography Isotope Ratio Mass Spectrometry for Anti-Doping; Herbert Tobias ; Thomas J Brenna ; Cornell University, Ithaca, NY Data Quality Control Measures for Forensic Mass Spectral Libraries; William E. Wallace ; Weihua Ji ; Karen W Phinney ; Stephen Stein ; National Institute of Standards & Technology, Gaithersburg, MD; National Institute of Standards and Technology, Gaithersburg, MD A DART-MS and In-source CID Reverse Library Search Approach for Rapid Screening of Drugs of Abuse; Frederick Li ; Joseph Tice ; Stephen Shrader ; Brian D Musselman ; IonSense, Inc. Saugus, MA; Shrader Software Solutions, Inc, Grosse Pointe Park, MI Forensic Identification of Unknown Compounds in Human Urine Using Complimentary Software with High- Resolution Data and Theoretical Fragmentation Spectra; Kristine Van Natta ; Marta Kozak ; Xiaolei Xie ; Mindy Gao ; Thermo Fisher Scientific, San Jose, CA Rapid Screening of Methylamphetaminein Hair of Drug Addicts using DSA-TOF; Baohua Shen ; Xianyi Zhuo ; Jingchao Lin ; Chengyuan Cai ; Lizhong Yang ; Yongming Xie ; Institue of Forensic Science, Ministry of Justice, Shanghai, China; PerkinElmer Management (Shanghai) Co., Ltd, Shanghai, China High-throughput LDTD-MS/MS for Quantification of GHB in Hair, Urine and Saliva; Annie-Claude Bolduc ; Réal Paquin ; Serge Auger ; Alex Birsan ; Jean Lacoursière ; Pierre Picard ; Université Laval, Quebec, Canada; Phytronix Technologies, Inc. Quebec, Canada Tracking the Ages of Latent Fingerprints using Triacylglycerols as an Age Marker; Kelly O Neill ; Young Jin Lee ; Iowa State University, Ames, IA; Iowa State University, Ames, Iowa Detection and Mapping of Proteomic Blood Signatures in Fingerprints for Forensic Analysis; Lisa Deininger ; Ekta Patel ; Malcolm R Clench ; Vaughn Sears ; Chris Sammon ; Simona Francese ; Sheffield Hallam University, BMRC Sheffield, United Kingdom; Centre for Applied Science and Technology, Home Office, St Albans, United Kingdom; Sheffield Hallam University, MERI, Sheffield, United Kingdom Investigating Environmental Degradation of Trace Explosives with Thermal Desorption DART-MS; Edward Sisco ; Marcela Najarro ; Jeffrey Lawrence ; Katherine Schilling ; NIST, Rockville, MD; Defense Forensic Science Center, Gillem Enclave, GA Metallic Muzzle Discharge Gunshot Residue Analysis By Dart-TOF-MS; Emily Lennert ; Candice Bridge ; National Center for Forensic Science, Orlando, FL Laser Ablation Sample Transfer with Vacuum Capture for Forensic Sampling; Fabrizio Donnarumma ; Kermit K Murray ; Louisiana State University, Baton Rouge, LA Impact of Energetic Particles on Proteinaceous Specimens; Christopher Rollman ; Mehdi Moini ; George Washington University, Washington, DC PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

105 TUESDAY POSTERS TP 6 TP 64 TP 65 TP 66 TP 67 TP 68 TP 69 TP 70 TP 7 TP 7 Species Identification using Bayesian Modeling and Mass Spectrometry; Jennifer Teubl ; Heyi Yang ; Donald Siegel ; David Fenyo ; NYU Langone Medical Ctr, NY, NY; Office of Chief Med Exam, New York, NY; NYU Langone Medical Center, New York, NY Tackling the Sensitivity using an Improved Proteomics Methodology: from Cultural Heritage to Forensic Studies; Fabrice Bray ; Stephanie Devassine ; Nicolas Garnier ; Christian Rolando ; Caroline Tokarski ; USR CNRS 90 MSAP, Villeneuve d Ascq, France; SARL Laboratoire Nicolas Garnier, Vic le Comte, France In-Depth Analysis of Saliva N-glycans Found in Live Human and Corpse for the Discovery of Post-mortem Interval (PMI) Marker; Bum Jin Kim, ; Dong-Gi Lee ; Jong- Soon Choi, ; Hyun Joo An, ; GRAST, Chungnam National University, Daejeon, Republic of Korea; AGRS, Chungnam National University, Daejeon, Republic of Korea; Division of Life Science, Korea Basic Science Institute, Daejeon, Republic of Korea Postmortem Identification of Metabolizer Type through CYP Quantification and Polymorphism Identification; Brigitte Desharnais, ; Pascal Mireault ; Cameron D. Skinner ; Laboratoire de sciences judiciaires et de médecine légale, Montréal, QC; Concordia University, Montreal, Canada Protein Profiling of Decedent Scalp Hair Segments Exhibiting a Post-Mortem Hair Root Band; McKay B. Allred ; Brian A. Eckenrode ; Traci L. Carlson ; Jamie N. Fleming ; Nicholas R. Vercruysse ; Andrew W. Plotner ; Hilda S. Castillo ; Dawnie W. Steadman ; Lee M. Jantz ; Kathleen Hauther ; Jack Hietpas ; JoAnn Buscaglia ; Stephen D. Shaw ; Mehdi Moini ; Joseph Donfack ; FBI Laboratory, Quantico, VA; University of Tennessee, Knoxville, TN; George Washington University, Washington DC Quantification of Seven Nerve Agent Compounds by ESI and APCI-MSMS; Kathleen Housman ; Jonathan Oyler ; USA Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD Validation of a GC/MS/MS Method for the Analysis of Chemical Warfare Agents (CWAs); Thomas Rusek ; Benjamin L Oyler ; Jonathan Oyler ; USAMRICD, ABerdeen Proving Ground, MD; U. Maryland, Baltimore, MD; USAMRICD, Aberdeen Proving Ground, MD Rapid and Unambiguous Identification of Ricin in Complex Matrices using a High Throughput, Integrated Immunoaffinity, Proteolysis and Mass Spectrometry Approach; Bao Quoc Tran ; Kathleen J. Housman ; Samir V. Deshpande ; James D. Wright ; Mary M. Wade ; Jonathan M Oyler ; Raymond F. Sullivan ; Science and Technology Corporation, Belcamp, MD - Maryland; US Army Medical Research Institute for Chemical Defense, Aberdeen Proving Ground, MD - Maryland; US Army Edgewood Chemical and Biological Center, Aberdeen Proving Ground, MD - Maryland DART-TOF-MS and ATR-FTIR Analysis of Silicone Based Personal Lubricants; Lauren Harvey ; Candice Bridge ; National Center for Forensic Science, Orlando, FL Analytical Validation of a Portable, Ambient Sampling Mass Spectrometer for High Throughput, Forensic Evidence Screening; Zachary E Lawton ; William L Fatigante ; Jamie R Wieland ; Michael C Gizzi ; Herbert Oberacher 4 ; Christopher C Mulligan ; Department of Chemistry, Illinois State University, Normal, IL; Department of Technology, Illinois State University, Normal, IL; Department of Criminal Justice Sciences, Illinois State University, Normal, IL; 4 Institute of Legal Medicine, Innsbruck Medial University, Innsbruck, Austria TP 7 TP 74 TP 75 TP 76 TP 77 TP 78 TP 79 TP 80 TP 8 TP 8 Transportable GC/MS for the Rapid Detection and Identification of Suspected Drug Compounds in Field Operations; Philip Tackett ; Mitch Wells ; FLIR Systems, Inc., West Lafayette, Indiana; FLIR Systems, Inc., West Lafayette, IN Detection and On-Site Presumptive Testing of a Clandestine Drug Laboratory using a Portable Mass Spectrometer; Ethan McBride ; Phillip Mach ; Kenneth C Wright ; Guido F Verbeck ; University of North Texas, Denton, TX; Inficon, Syracuse, NY Portable MS Systems vs. the Daubert Standard: Anticipating the Admissibility of a New Technology for Forensic Investigation; Angelica Traub ; Zachary E. Lawton ; Jamie R. Wieland ; Michael C. Gizzi ; Christopher C Mulligan ; Department of Chemistry, Illinois State University, Normal, IL; Department of Technology, Illinois State University, Normal, IL; Department of Criminal Justice Sciences, Illinois State University, Normal, IL Examining the Legality of using Ambient Sampling, Portable Mass Spectrometers in Criminal Justice Applications; Alessandra Bruno ; Michael C Gizzi ; Jamie R Wieland ; Christopher C Mulligan 4 ; Illinois State University, Normal, IL; Department of Criminal Justice Sciences, Illinois State University, Normal, IL; Department of Technology, Illinois State University, Normal, IL; 4 Department of Chemistry, Illinois State University, Normal, IL Chiral Separation and Quantitation of Cathinone Related Drugs by Gas chromatography Mass spectrometry; Rashed Alrumaithi ; Mohammed Meetani ; Saif Eldin Khalil ; Khalid Alsumaiti ; Dubai Police, Dubai, Dubai; United Arab Emirates University, Al Ain, United Arab Emirates.; Dubai Police, Dubai, Dubai, United Arab Emirates. Improved Sensitivity for the Qualitative and Quantitative Analysis of Active Ricin by MALDI-TOF Mass Spectrometry; Dongxia Wang ; Jakub Baudys ; John R Barr ; Suzanne R Kalb ; Centers of Disease Control and Prevention (CDC), Atlanta, GA; Centers for Disease Control and Prevention, Atlanta, GA Glycoproteins A SPEG coupled Mass Spec Approach for Understanding the Glycosylated and Sialylated Proteome of CHO Mutants; Ozge Can, ; Deniz Baycin Hizal ; A. Emin Atik ; R. Serdar Alpan ; Sharon Krag 4 ; Hui Zhang 5 ; Michael Betenbaugh 6 ; Acibadem University, Istanbul, Turkey; Turgut Biotechnology Group, Istanbul, Turkey; Johns Hopkins University, Baltimore, Maryland; 4 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; 5 Johns Hopkins University School of Medicine, Baltimore, MD; 6 Johns Hopkins University, Baltimore, MD Studying the Effect of Glycan and Peptide Backbone Structures on Kinetics of N-glycan Release by PNGase F with MRM Quantization; Yining Huang ; Ron Orlando ; University of Georgia, CCRC, Athens, GA; University of Georgia, CCRC Athens, GA Mass Spectrometry-based Quantitative Analysis for Decoding Site-specific Alteration of Sialoglycoproteome in EGFR-subtype of Non-small Cell Lung Cancers; Yi-Ju Chen ; Yu-Hsien Lin, ; Yu-Ju Chen ; Institute of Chemistry, Academia Sinica, Taipei City, Nankang; Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan (R.O.C.); Institute of Chemistry, Academia Sinica, Taipei, Taiwan (R.O.C.) Features of N-Glycosylation of Immunoglobulins from Two Knockout Pig Models; Emy Komatsu ; Marjorie Buist ; Paul Gabriel Lopez ; Apolline Salama ; David Sachs, 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 05

106 GENERAL TUESDAY INFORMATION POSTERS TP 8 TP 84 TP 85 TP 86 TP 87 TP 88 TP 89 4 ; Cesare Galli 5, 6, 7 ; Andrea Perota 5 ; Sophie Conchon 8 ; Jean-Paul Concordet 9 ; Jean-Paul Judor 8 ; Giovanna Lazzari 6, 7 ; Jean-Paul Soulillou 8 ; Helene Perreault ; University of Manitoba, Winnipeg, MB; Xenothera, Nantes, France; Massachusetts General Hospital, Boston, MA; 4 Harvard Medical School, Boston, MA; 5 Avantea Laboratorio Di Tecnologie Della Riproduzione, Cremona, Italy; 6 Fondazione Avantea, Cremona, Italy; 7 University of Bologna, Bologna, Italy; 8 Université de Nantes, Nantes, France; 9 Université de Paris-Descartes, Paris, France Uncovering Single Glycoprotein Signatures using a One-pot Dual Nanoprobe-based Mass Spectrometry Assay; Mira Anne C. dela Rosa,, ; Wei-Chun Chen ; Yi-Ju Chen ; Rofeamor P. Obena ; Chih-Hsiang Chang ; Rey Y. Capangpangan ; Tung-Hung Su 4 ; Chi-Ling Chen 4 ; Pei-Jer Chen 4 ; Yu-Ju Chen ; Department of Chemistry, National Taiwan University, Taipei, Taiwan (R.O.C.); Nano Science and Technology Program, Taiwan International Graduate Program, Academia Sinica, Taipei, TAIWAN (R.O.C.); Institute of Chemistry, Academia Sinica, Taipei, Taiwan (R.O.C.); 4 Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (R.O.C.) Serum N-Glycome and Glycoproteome Analysis for Oral Cancer Patients; Chuan Fa Chang ; Shu-Jie Chang ; National Cheng Kung University, Tainan, TW The Comparison of N-glycomics of Membrane Protein with Proteins of Whole Cell Lysate of Breast Cancer Cell Lines; Parvin Mirzaei ; Shiyue Zhou ; Rui Zhu ; Wenjing Peng ; Yehia Mechref ; Texas Tech University, Lubbock, Texas Characterization of Site-specific N-glycopeptide Isoforms of Alpha--acid Glycoprotein from an Interlaboratory Study using LC-MS/MS; Ju Yeon Lee ; Hyun Kyoung Lee, ; Gun Wook Park, ; Heeyoun Hwang ; Hoi Keun Jeong, ; Ki Na Yun, ; Eun Sun Ji, 4 ; Kwang Hoe Kim, ; Jun Seok Kim 5 ; Jong Won Kim 6 ; Sung Ho Yun 7 ; Chi-Won Choi 7 ; Seung Il Kim 7 ; Jong-Sun Lim 8 ; Seul-Ki Jeong 8 ; Young-Ki Paik 8 ; Soo-Youn Lee 9, 0 ; Jisook Park ; Su Yeon Kim 0 ; Young-Jin Choi, ; Yong-In Kim ; Jawon Seo ; Je-Yoel Cho ; Myoung Jin Oh ; Nari Seo ; Hyun Joo An ; Jin Young Kim ; Jong Shin Yoo, ; Korea Basic Science Institute, Cheongju-Si, Republic of Korea; Chungnam National University, Daejeon, Republic of Korea; Sogang University, Seoul, Republic of Korea; 4 Hannam University, Daejeon, Republic of Korea; 5 Korea Polytechnics, Gyeonggi, Republic of Korea; 6 Osong Medical Innovation Foundation, Cheongju, Republic of Korea; 7 Korea Basic Science Institute, Daejeon, Republic of Korea; 8 Yonsei University, Seoul, Republic of Korea; 9 Sungkyunkwan University, Seoul, Republic of Korea; 0 Samsung Medical Center, Seoul, Republic of Korea; Samsung Biomedical Research Institute, Seoul, Republic of Korea; Seoul National University, Seoul, Republic of Korea N-Glycoproteomic Characterization of Recombinant Human Cytomegalovirus Glycoprotein B using Multienzymatic Proteolysis Coupled to LC-MS/MS and CZE-MS/MS; Nicolas Smargiasso ; Johann Far ; Catherine Navarre ; Gabriel Mazzucchelli ; Dominique Baiwir ; Marc Boutry ; Edwin De Pauw ; University of Liege, Liege, Belgium; University of Louvain, Louvain-la-Neuve, Belgium Ultrasensitive Glycoproteomics pairing Liquid Phase Isoelectric Focusing and Data Independent LC-MS reveals Site Specific N-glycosylation Alterations in Gastric Adenocarcinoma; Josh Smith ; Colin Clarke ; Stefan Mittermayr ; Jonathan Bones ; National Institute of Bioprocessing Research and Training (NIBRT), Dublin, Ireland Glycomic Profiling of Human Hyaluronidase ; Abby S Gelb ; Christine Booth ; Melanie A Simpson ; Eric D Dodds ; TP 90 TP 9 TP 9 TP 9 TP 94 TP 95 TP 96 University of Nebraska-Lincoln, Lincoln, NE; University of Nebraska-Lincoln, Lincoln, NE The Role of N-Glycosylation in Receptor Tyrosine Kinase (RTK) Signaling; Kevin B Chandler ; Deborah R Leon ; Rosana D Meyer ; Nader Rahimi ; Catherine E Costello ; Boston University School of Medicine, Boston, MA MALDI-MS Characterization of Glycan Multivalency in Synthetic Glycan-Protein Conjugates; Christopher C. Lai ; David Farnsworth ; Jeffrey C. Gildersleeve ; James A. Kelley ; CBL, CCR, NCI-Frederick, NIH, Frederick, MD - Maryland; National Institutes of Health, Frederick, MD Glycoproteomic Analysis of HIV Latently Infected Cells and Plasma from Elite Suppressors Identify Important Glycoproteins in virus-host Interaction; Weiming Yang ; Hui Zhang ; Johns Hopkins University School of Medicine, Baltimore, MD Revealing the Functions of Glycosylation Genes in Breast Cancer Cell Brain Metastasis with Gene Silencing Coupled to LC-MS/MS Glycomics; Wenjing Peng ; Shiyue Zhou ; Xue Dong ; Yehia Mechref ; Texas Tech University, Lubbock, TX Deciphering Glycomics and Neuroproteomic Alterations in Experimental TBI: Comparative Analysis of Aspirin and Clopidogrel Treatment; Hisham Bahmad ; Rui Zhu ; Naify Ramadan ; Hussein Abou Abbass ; Shiyue Zhou ; Xue Dong ; Firas Kobeissy ; Yehia Mechref ; American University of Beirut, Beirut, Lebanon; Texas Tech University, Lubbock, Texas Effect of Aspirin on Platelet Glycoproteins in Presence of Collagen; Punit Shah ; Weiming Yang ; Shisheng Sun ; Faraday Naudeur ; Hui Zhang ; Johns Hopkins University School of Medicine, Baltimore, MD Comparative Transcriptomic and Proteomic Analysis of Productively HIV--infected and Bystander Monocytederived Macrophages during HIV- Infection of Uninfected Donors; Isabel Martinez Ferrando; Johns Hopkins University School of Medicine, Baltimore, MD High Mass Accuracy/High Performance MS Methods & Developments 97 - TP 97 Disulfide Linked Linear Peptides ANP, Insulin, ShK : Automatic Assignment of Exact-Mass ESI-MS/ MS Fragment Ion Structures Using the MASSPEC Algorithm; Marshall M. Siegel ; Gary Walker ; Serhiy Y Hnatyshyn ; Eugene Ciccimaro ; Asoka Ranasinghe ; MS Mass Spec Consultants, Fair Lawn, NJ; MS Mass Spec Consultants, Fair Lawn, NJ; Bristol-Myers Squibb, Princeton, NJ TP 98 Optimisation of Two-Dimensional FT-ICR MS for IR-ECD; Maria Van Agthoven ; Federico Floris ; Alice Lynch ; Christopher Wootton ; Lionel Chiron ; Mark P Barrow ; Marc-André Delsuc 4 ; Christian Rolando 5 ; Peter B O Connor ; University of Warwick, Coventry, Midlands; University of Warwick, Coventry, United Kingdom; CASC4DE, Strasbourg, France; 4 IGBMC, Illkirch- Graffenstaden, France; 5 Université Lille, Sciences et Technologies Villeneuve d Ascq, France TP 99 Constructing High Resolution Consensus Spectra for a Peptide Tandem Mass Spectral Library; Sergey L Sheetlin ; Yuri A Mirokhin ; Dmitrii V Tchekhovskoi ; Xiaoyu Yang ; Stephen E Stein ; NIST, Rockville, MD TP 00 Mass Defect-based N,N-Dimethyl Leucine (DiLeu) Labels for quantitative Proteomics and Amine Metabolomics of Pancreatic Cancer Cells; Ling Hao ; Jillian Johnson ; Chirstopher Lietz ; W.John Kao ; Lingjun li ; university of Wisconsin Madison, madison, WI; University of Wisconsin-Madison, Madison, WI PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

107 TUESDAY POSTERS TP 0 TP 0 TP 0 TP 04 TP 05 TP 06 TP 07 TP 08 TP 09 TP 0 Using Simultaneous Waveform Averaging and Ion Counting Techniques to Expand the Quantitative Measurement Range in a Time-of-Flight Mass Spectrometer; Toshinobu Hondo, ; Yuki Miyada ; Yosuke Kawai ; Kentaro Terada ; Michisato Toyoda, 4 ; MS- Cheminformatics, Inabe-gun, Mie; Project Research Center for Fundamental Sciences, Graduate School of Science, Osaka University, Osaka, Japan; Department of Earth and Space Science, Graduate School of Science, Osaka University, Osaka, Japan; 4 Department of Physics, Graduate School of Science, Osaka University, Osaka, Japan Computer Modeling of Trapped-Ion Cell Capacitance for Optimization of Ion Image Charge Detection Mass Spectrometry; Steven C Beu ; Nathan K Kaiser ; Donald F Smith ; Christopher L Hendrickson, ; S C Beu Consulting, Austin, TX; Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, FL; Department of Chemistry and Biochemistry, Tallahassee, FL Static Harmonization of Dynamically Harmonized FT ICR Cell. High Order Contributions to the Electric Field; Ekaterina Zhdanova, ; Gleb Vladimirov, ; Yury Kostyukevich, ; Eugene Nikolaev ; Moscow Institute of Physics and Technology, Dolgoprudny Moscow Oblast, Russia; Institute for Energy Problems of Chemical Physics, Moscow, Russia; Skolkovo Institute of Science and Technology, Skolkovo Moscow Oblast, Russia Setup and Application of Gas-phase APCI Coupled to Ultra-high Resolution Mass Spectrometry for Gas Chromatography and Thermal analysis; Martin Sklorz ; Christopher Paul Rüger ; Theo Schwemer, ; Toni Miersch ; Thomas Arthen-Engeland ; Ralf Zimmermann,,4 ; University of Rostock, Analytical Chemistry, Rostock, Germany; HICE - Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health, Munich, Germany; Bruker Daltonic GmbH, Bremen, Germany; 4 Helmholtz Zentrum München, Cooperation Group Comprehensive Molecular Analytics, Munich, Germany Charge Ordered Parallel Ion analysis (CHOPIN) Mass Spectrometry Enhances Global Sequence Coverage, Deep Proteomics and PToMics; Simon Davis ; Philip Charles ; Lin He ; Benedikt M Kessler ; Roman Fischer ; Oxford University, Oxford, United Kingdom; Bioinformatics Solutions Inc., Waterloo, Canada Implementation of the All Ion Fragmentation Analysis for Targeted/Untargeted Metabolomic Approaches; Enrique Sentandreu ; Shannon R Sweeney ; Jennifer Chiou ; Stefano Tiziani ; Dell Pediatric Research Institute, Austin, Tx Accurate FT-ICR MS with Fluctuating Ion Sources; Konstantin O Nagornov ; Anton N Kozhinov ; Yury O Tsybin ; Spectroswiss Sàrl, Lausanne, Switzerland Characterization of a Modified Dynamically Harmonized FT-ICR Cell at High Magnetic Field; Christopher L Hendrickson, ; Nathan K Kaiser ; Steven C Beu ; Greg T Blakney ; John P Quinn ; Donald J Smith ; Alan G Marshall, ; Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, FL; Department of Chemistry, Florida State University Tallahassee, FL; S C Beu Consulting, Austin, TX Boosting FTMS Performance via Advanced Data Acquisition Electronics and Signal Processing; Yury O Tsybin ; Konstantin O Nagornov ; Anton N Kozhinov ; Spectroswiss Sàrl, Lausanne, Switzerland Implementation of a High-performance FPGA-based Data Acquisition System for FTMS; Anton Kozhinov ; Konstantin Nagornov ; Yury Tsybin ; Spectroswiss Sàrl, Lausanne, Switzerland TP TP TP TP 4 TP 5 TP 6 TP 7 TP 8 TP 9 Design of Automated Quantitative Optimization Software for Hi-Resolution Analysis; Eugene F. Ciccimaro ; Asoka Ranasinghe ; Timothy Olah ; Richard Baran ; Mark Sanders ; Jonathan L Josephs ; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Princeton, NJ; Thermo Fisher Scientific, San Jose, CA 9-plex Metabolic Labeling with NeuCode SILAC; Katherine A Overmyer ; Elyse C Freiberger ; Stefka Tyanova ; Anna E Merrill ; William Wood ; Marwan Elmasri ; Alexander S Hebert ; Michael S Westphall ; Joel C Bradley ; Juergen H Cox ; Joshua J Coon ; University of Wisconsin Madison, Madison, WI; Max Planck Institute of Biochemistry, Martinsried, DE; Cambridge Isotope Laboratories, Inc. Tewksbury, MA Imaging MS: Disease Markers - 44 New Insights into the Microenvironment of Cancerous Tissue by Combined Mass Spectrometry, Microscopy and Multivariate Analysis; Tina Angerer ; John Stephen Fletcher ; University of Gothenburg, Gothenburg, Sweden Typing of Colon and Lung Adenocarcinoma using High-throughput Imaging Mass Spectrometry; Rita Casadonte ; Mark Kriegsmann ; Rémi Longuespée ; Petra Wandernoth, ; Cristina Mohanu ; Tiemo Katzenberger 4 ; Daniela Aust 5 ; Gustavo Baretton 5 ; Jörg Kriegsmann,, 6 ; Proteopath GmbH, Trier, Germany; University of Heidelberg, Heidelberg, Germany; Molekularpathologie Trier, Trier, Germany; 4 Department of Pathology, Hospital Aschaffenburg, Aschaffenburg, Germany; 5 University of Dresden, Dresden, Germany; 6 Center for Histology, Cytology and Molecular Diagnostics Trier, Trier, Germany Desorption Electrospray Ionisation Imaging towards Enhanced Breast Cancer Diagnosis; Dipa Gurung ; James McKenzie ; Francesca Rosini ; Luisa Doria ; Anna Mroz ; Rathi Ramakrishnan ; Edward R St John ; Jeremy K Nicholson ; Zoltan Takats ; Imperial College London, South Kensington Campus London, United Kingdom MALDI-MS Imaging of Lipid Changes after PI-K Inhibition in Colorectal Cancer Liver Metastases; Fiona Henderson ; Irma Berrueta Razo ; Nicholas Lockyer ; Omar Belgacem ; Kaye J Williams 4 ; Adam McMahon ; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, England; Manchester Institute of Biotechnology, University of Manchester, Manchester, England; Shimadzu, Manchester, England; 4 Stopford Building, University of Manchester, Manchester, England Multimodal imaging of lipids in a Zebrafish Melanoma Model by PET and DESI-MS; Emrys Jones ; Fiona Henderson ; Anthony Midey ; Adam Hurlstone ; Duncan Foster ; Hannah Johnston ; Kaye Williams ; Adam W McMahon ; Emmanuelle Claude ; Waters Corporation, Wilmslow, UK; Wolfson Molecular Imaging Centre, Manchester, UK; Waters Corporation, Beverly, Massachusetts Comparative Mapping of PSA and N-glycan Distributions in FFPE Prostate Cancer Tissues using MALDI-FTICR and Rapid MALDI-TOF Mass Spectrometry Imaging; Richard R Drake ; Peggi M Angel ; Hendrik Jan Kobarg ; Shannon Cornett ; Medical University of South Carolina, Charleston, SC; SCiLS GmbH, Bremen, Germany; Bruker Daltonic, Billerica, MA Imaging Mass Spectrometry Approach for the Diagnosis of Carcinoma of the Cervix; Rita Casadonte ; Rémi Longuespée ; Mark Kriegsmann ; Michael Becker ; Sören-Oliver Deininger ; Mike Otto ; Jörg Kriegsmann, 4 ; Proteopath GmbH, Trier, Germany; University of Heidelberg, Heidelberg, Germany; Bruker Daltonik GmbH, Bremen, Germany; 4 Centre for Histology, Cytology and Molecular Diagnostics, Trier, Germany 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 07

108 GENERAL TUESDAY INFORMATION POSTERS TP 0 MALDI Imaging a Tool for Clinical Diagnostic Classification of Prostate Cancer Subgroups; Birte Beine ; Tobias Boskamp ; Dimo Dietrich ; Hendrik Jan Kobarg 4 ; Konrad Steinestel 5 ; Piotr Widlak 6 ; Barbara Sitek 7 ; Helmut Erich Meyer 8 ; Corinna Henkel 8 ; ISAS e.v., Dortmund, NRW; Center for Industrial Mathematics, University of Bremen, Bremen, Germany; Institute of Pathology, University Hospital Bonn (AöR), Bonn, Germany; 4 SCiLS GmbH, Bremen, Germany; 5 Gerhard-Domagk- Institute of Pathology, University Hospital Münster (UKM), Münster, Germany; 6 Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska - Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland; 7 Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany; 8 ISAS - e.v., Dortmund, Germany TP Molecular Markers of Serous Ovarian Cancer Aggressiveness and Surgical Outcome by Ambient Ionization Mass Spectrometry Imaging; Marta Sans Escofet ; Kshipra Gharpure ; Jialing Zhang ; Jinsong Liu ; Anil K. Sood ; Livia S. Eberlin ; University of Texas at Austin, Austin, TX; the University of Texas M.D Anderson Cancer Center, Houston, TX TP Linking Lipid Metabolism, Hypoxia, Radiation Therapy and Metastasis using DESI Imaging Mass Spectrometry; Erik J. Soderblom ; Kathleen Ashcraft ; Matt W. Foster ; Emmanuelle Claude 4 ; Emrys A Jones 4 ; James Langridge 4 ; M. Arthur Moseley ; Mark Dewhirst ; Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC; Radiation Oncology, Duke University Medical Center, Durham, NC; Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC; 4 Health Sciences, Waters Corp, Manchester, UK TP Elemental Analysis and Imaging of Stroke-affected Brain Tissues by Utilizing Laser Ablation-inductively Coupled Plasma-Mass Spectrometry: Diagnostic Study; Khalid A. Al-Saad ; Mohamed H Ali ; MD Fazle Rakib ; Eman M Fayyad ; Rick Dijkhuizen ; Geralda V Tilborg ; Qatar University, Doha, Doha; Qatar Biomedical Research Institute, Doha, Qatar; University Medical Center Utrecht, Utrecht, Netherlands TP 4 Molecular Signature Discovery of Human Chronic Traumatic Encephalopathy Tissues using Mass Spectrometry Imaging; Bo Yan ; Dharmendra B. Goswami ; Deborah R Leon ; Mark E McComb ; Ann C. McKee, ; Catherine E Costello ; Boston University School of Medicine, Boston, MA; United States Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA TP 5 MALDI Imaging of Neuronal Plasticity: Analysing Fine Adaptations with Large Effects; Jakob Meier-Credo ; Michael Becker ; Alice Ly ; Shahar Or ; Irina Epstein ; Thomas Hagedorn ; Tamas Dalmay ; Johannes J Letzkus ; Erin Schuman ; Julian Langer ; Max-Planck-Institute for Brain Research, Frankfurt Am Main, Germany; Bruker Daltonik GmbH, Bremen, Germany TP 6 Nanoparticle Matrix Implantation Mass Spectrometry Imaging Discovers and Quantifies Lipid Biomarkers of Traumatic Brain Injury and Tracks Therapeutic Response; Aurelie Roux ; Ludovic Muller ; Shelley N Jackson ; Jeremy Post; Katherine Baldwin ; Barry Hoffer 4 ; Carey Balaban 5 ; Damon Barbacci 6 ; Albert J Schultz 7 ; Shawn Gouty 8 ; Brian M Cox 8 ; Amina S Woods 9 ; All Children s Hospital Johns Hopkins Medicine, Saint Petersburg, FL; NIH/NIDA-IRP, Baltimore, MD; Philadelphia College of Osteopathic Medicine, Philadelphia, PA; 4 University Hospitals of Cleveland, Cleveland, OH; 5 University of Pittsburgh, Pittsburgh, PA; 6 Ionwerks, Gaithersburg, MD; 7 Ionwerks Inc, Houston, TX; 8 Uniformed Services University, Bethesda, MD; 9 NIDA-IRP, NIH Baltimore, MD TP 7 TP 8 TP 9 TP 0 TP TP MALDI Mass Spectrometry Imaging in Alzheimer s disease mouse model Het CRND8 (+/-);Lyna SellamI ; Marcia Roy ; Matthew E Openshaw ; Luis Mancera ; Omar Belgacem ; Shimadzu, Kratos Manchester, United Kingdom; University of Edinburgh, Edinburgh, UK Simultaneous MALDI MS Imaging and Quantitation of Multiple Neurotransmitters In Parkinson s Disease Models; Elva Fridjonsdottir ; Mohammadreza Shariatgorji ; Anna Nilsson ; Patrik Källback ; Xiaoqun Zhang ; Per Svenningsson ; Per E. Andren ; Uppsala University, Uppsala, Sweden; Karolinska Institutet, Stockholm, Sweden; Uppsala University, Uppsala, SE Detection of Ganglioside Lipid Species in the Brain of Mucopolysaccharidosis Type II Mouse by Imaging Mass Spectrometry; Martin Dufresne ; Daniel Guneysu ; Martin Marcinkiewicz ; Anthony Regina ; Michel Demeule ; Pierre Chaurand 4 ; Université de Montréal, St-Hyacinthe, QC; Cytochem Inc., Montreal Quebec, Canada; Angiochem Inc., Montréal, QC, Canada; 4 University of Montreal, Montreal, QC Studying the Sphingolipid Pathway into Co-morbidity of Depression and Alcoholism by MALDI Imaging FT- ICR Mass Spectrometry; Christian P Muller ; Matthias Witt ; Michael L Easterling ; Jens Fuchser ; Beckmann Janine ; Thomas Stockl ; Eva Sprenger ; Jens Tiesel ; Sabine E Huber ; Davide Amato ; Erich Gulbins 4 ; Martin Reichel ; Johanes Kornhuber ; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany; Bruker Daltonik GmbH, Bremen, Germany; Bruker Daltonics, Billerica, MA; 4 Department of Molecular Biology, University of Duisburg- Essen, Essen, Germany Molecular Mapping of Gangliosides and Related Lipids using Mass Spectrometry Imaging with Ion Mobility Separation; Bindesh Shrestha ; Hernando Olivos ; Khaja Muneeruddin ; Miguel Sena-Esteves ; Scott A Shaffer ; Waters Corp., Beverly, MA; Waters Corporation, Beverly, MA; University of Massachusetts Medical School, Worcester, MA Evaluating the Viability of Kidney Transplants using High-speed MALDI-Imaging; Shane R Ellis ; Tim C van Smaalen ; Nadine E Mascini, ; Berta Cillero-Pastor ; Tiffany Porta ; Benjamin Balluff ; Carine J Peutz-Koostra ; L.W.E van Heurn 4 ; Ron M A Heeren ; M4I, Maastricht University Maastricht, the Netherlands; Maastricht UMC+, Maastricht, Netherlands; FOM Institute AMOLF, Amsterdam, Netherlands; 4 University of Amsterdam, Amsterdam, The Netherlands TP Proteomic Mass Imaging of Kidney from Type Diabetes (TD) Rat Model; Hirata Chie ; Kuzuhara Yuki ; Iwasaki Noriyuki ; Kudo Toshiji ; Nirasawa Takashi ; Masuyama Kei ; Kakuda Nobuto ; Wakazono Hiroshi ; Yanagi Hiroyuki ; Masaya Ikegawa 4 ; Doshisha University, Kyotanabe, Japan; Bruker Daltonics K.K., Kanagawa, Japan; Ono Pharmaceutical Co., Ltd., Fukui, Japan; 4 Doshisha University, Kyotanabe City TP 4 TP 5 Differentiating Macrophages in Atherosclerotic Plaques using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging; Pegah Khamehgir-Silz ; Florian Schnitter ; Andreas H. Wagner ; Sabine Schulz ; Markus Hecker ; Bernhard Spengler ; Justus Liebig University, Giessen, Germany; Ruprecht-Karls-University, Heidelberg, Germany What Can We Learn from the Na+/K+ Ratio in Imaging Mass Spectrometry Experiments?; Roberto Fernandez ; Jone garate ; Sergio Lage ; Silvia Teres ; Pau Gonzalez ; Monica Higuera 4 ; Alfredo Maqueda ; Joan Bestard-Escalas 5 ; Daniel H Lopez 5 ; Francisca guardiola-serrano 4 ; Pablo V Escribá 4 ; Javier Rodriguez ; Gwendolyn Barceló-Coblijn 5 ; Jose A. Fernandez 6 ; Universidad del Pais Vasco, Leioa, PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

109 TUESDAY POSTERS TP 6 TP 7 TP 8 TP 9 TP 40 TP 4 TP 4 TP 4 Spain; Institut européen de chimie et biologie, Pessac, France; National Hospital for Paraplegics, Toledo, Spain; 4 University of the Balearic Islands, Palma Balearic Islands, Spain; 5 Institut d Investigació Sanitària de Palma, Palma Balearic Islands, Spain; 6 Universidad del Pais Vasco, leioa, Spain Analysis of Retinal Degeneration in a Leber Congenital Amaurosis Mouse Model Using High Spatial Resolution MALDI-Imaging Mass Spectrometry; David M. Anderson ; Zsolt Ablonczy ; Yiannis Koutalos ; Nico Verbeeck ; Raf Van De Plas, ; Jeffrey Spraggins ; Rosalie K. Crouch ; Richard M Caprioli ; Kevin L. Schey ; Vanderbilt University MSRC, Nashville, TN; Department of Ophthalmology, Storm Eye Institute, Medical University of South, Charleston, SC; Delft Center for Systems and Control (DCSC), Delft University of Technology, Delft, Netherlands Molecular Target Validation in Human Atherosclerosis Based on Mass Spectrometry Imaging and ImmunHistoChemistry Evaluation; Jonathan Stauber ; Gregory Hamm ; Sylvia Aldi ; Juliette Masure ; Kim Holmstrom ; Serife Arda 4 ; Danielle Van Keulen 5, 6 ; David Bonnel ; Ivana Bobeldijk-Pastorova 5 ; Dennie Tempel 6 ; Boye S Nielsen ; Michael Gudo 4 ; Jan NH Lindeman 7 ; Ulf Hedin ; Alain van Gool 5 ; Eva Hurt Camejo 8 ; ImaBiotech, MS Imaging Dept. Loos, France; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Bioneer, Hoersholm, Denmark; 4 Morphisto, Frankfurt Am Main, Germany; 5 TNO, Metabolic Health Research Leiden, The Netherland; 6 CardioGenx, Rotterdam, The Netherlands; 7 Leiden University Medical Centre, Leiden, The Netherlands; 8 AstraZeneca R&D, Gothenburg, Sweden Simultaneous Detection of N-glycans and Peptides from a Single FFPE Tissue Section by MALDI FT-ICR Imaging Mass Spectrometry; Peggi Angel ; Rita Casadonte ; Jörg Kriegsmann ; Richard Drake ; Medical University of South Carolina, Charleston, SC; Proteopath GmbH, Trier, Germany; Medical Univ of S Carolina, Charleston, SC The Effect of Oxygen on the Lipid Composition of Human Chondrocytes using MALDI Imaging; Brenda Bakker ; Gert Eijkel ; Ron Heeren ; Marcel Karperien ; Janine Post ; Berta Cillero-Pastor ; Developmental BioEngineering, University of Twente, Enschede, The Netherlands; The Maastricht Multimodal Molecular Imaging Institute (M4I), Maastricht University, Maastricht, The Netherlands Metabolite Profiling of Intestinal Microbiota by Mass Spectrometry Imaging for Biological Understanding of Gastrointestinal Disease; Gregory Hamm ; Juliette Masure ; Sylvain Normand ; David Bonnel ; Mathias Chamaillard ; Jonathan Stauber ; ImaBiotech, MS Imaging Dept. Loos, France; Center of Infection and Immunity of Lille (CIIL), Team 7, Inserm U09, CNRS UMR804, Lille, France Differential Human Pancreatic Lipid and Protein Distributions in Normal and Type Diabetes Revealed by Tissue Imaging Mass Spectrometry; Boone M Prentice ; Rachana Haliyur ; Nathaniel J Hart ; Audra M Judd ; Radhika Aramandla ; Marcela Brissova ; Jeffrey M Spraggins ; Jeremy L Norris ; Alvin C Powers ; Richard M Caprioli ; Vanderbilt University, Nashville, TN Lipid and Metabolite Distribution in Healthy and Diseased Brain Tissue using DESI and High Resolution Mass Spectrometry; Joseph H Kennedy ; Jeff Patrick ; Mariam ElNaggar ; Justin M Wiseman ; Prosolia, Inc. Indianapolis, IN Imaging Mass Spectrometry for the Pathological Studies of Cardiac Allografts; Terada Megumi ; Iwasaki Noriyuki ; Kudo Toshiji ; Nirasawa Takashi ; Bruneval TP 44 Prtrick ; Ishibashi-Ueda Hatsue 4 ; Masaya Ikegawa 5 ; Doshisha University, Graduate School of Brain Scie Kyoto, Japan; Bruker Daltonics K.K., Kanagawa, Japan; Georges Pompidou European Hospital, Paris, France; 4 National Cerebral and Cardiovascular Center, Osaka, Japan; 5 Doshisha University, Kyotanabe City High Spatial Resolution Lipid Imaging Offers Promising Perspectives in Sustaining Diagnosis of Human Lymphoma; Yousef El Aalamat ; Arndt Asperger ; Xian Mao ; Wim Waelput ; Thomas Tousseyn 4 ; Bart De Moor ; Etienne Waelkens 5 ; ESAT-STADIUS / iminds Medical IT, KU Leuven, Leuven, Belgium; shared first author, Bruker Daltonik GmbH,, Bremen, Germany; Dept. of Pathology, UZ-Brussel,, Brussel, Belgium; 4 Dept. Imaging and Pathology, KU Leuven,, Leuven,, Belgium; 5 Dept. Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium Imaging MS: Pharmaceutical Applications 45-6 TP 45 Towards Absolute Quantitative MALDI MS Imaging of Drugs; Patrik Kallback ; Theodosia Vallianatou ; Anna Nilsson ; Mohammadreza Shariatgorji ; Per E Andren ; Uppsala University, Uppsala, Uppsala; Uppsala University, Uppsala, Sweden TP 46 Derivatization Strategies for the Quantitation of Triamcinolone Acetonide in Cartilage by using Imaging Mass Spectrometry; Florian Barré ; Bryn Flinders ; Joao Garcia ; Laura Creemers ; Ron M A Heeren ; Berta Cillero- Pastor ; M4I Institute - Maastricht University, Maastricht, The Netherlands; Utrecht University, Utrecht, The Netherlands TP 47 D MALDI Mass Spectrometry Imaging to Empower Drug Distrubution And Quantitation Studies in Solid Tumors; Silvia Giordano ; Lavinia Morosi ; Pietro Veglianese ; Simonetta Andrea Licandro ; Roberta Frapolli ; Massimo Zucchetti ; Maurizio D Incalci ; Enrico Davoli ; IRCCS Istituto Mario Negri, Milano, Italy TP 48 Study of the Blood Brain Barrier Permeability using a Multimodal Imaging Approach; David Calligaris ; Fa-Ke Lu ; Armen Changelian ; Isaiah Norton ; Brett L Carlson ; Jeffrey Agar ; William F Elmquist 4 ; Daniel MA ; Jann N Sarkaria ; Nathalie YR Agar ; Department of Neurosurgery, Brigham and Women s Hospital - Harvard Medical School, Boston, MA; Mayo Clinic, Rochester, MN; Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA; 4 Department of Pharmaceutics, University of Minnesota, Minneapolis, MN TP 49 Comparison of LESA-MS to MALDI-MS for Mouse Whole Body Tissue Profiling: Diclofenac and Major Metabolites; Walter Korfmacher ; Gargey Yagnik ; Yongyi Luo ; Stacy Ho ; Liduo Shen ; Terry Wilper 4 ; Karen Norton 4 ; Eric Solon 5 ; Hanlan Liu ; Sara Savage 4 ; Thomas O Shea ; Genzyme, Waltham, MA; Genzyme, a Sanofi company Waltham, MA; Sanofi, Waltham, MA; 4 Genzyme, Framingham, MA; 5 QPS, Newark, DE TP 50 Matrix Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging of Therapeutic Oligonucleotides: Application to Antisense Therapy; C. Logan Mackay ; John G Swales ; Richard J A Goodwin ; SIRCAMS, TP 5 TP 5 Edinburgh, UK; AstraZeneca, Cambridge, UK Microinjection and High-throughput Alignment of Cellular Spheroids for MALDI Mass Spectrometry Imaging Analysis; Jillian Johnson ; Fengfei Ma ; Weiyuan John Kao ; Lingjun Li ; University of Wisconsin-Madison, Madison, WI Applications of Single-Probe Device for Ambient Mass Spectrometry Imaging Analysis: Human Corneas and D Artificial Tumors; Xiang Tian ; Wei Rao ; Ning Pan ; Haiqing Yu ; Dimitrios Karamichos ; Zhibo Yang ; University 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 09

110 GENERAL TUESDAY INFORMATION POSTERS TP 5 TP 54 TP 55 TP 56 TP 57 TP 58 TP 59 TP 60 TP 6 of Oklahoma, Dept. of Chem & Biochem Norman, OK; University of Oklahoma Health Science Center, OKC, OK Application of Imaging Mass Spectrometry to Assess Ocular Drug Transit; Kerri Grove ; Viral Kansara ; Melissa Prentiss ; Debby Long ; Muneto Mogi ; Sean Kim ; Patrick Rudewicz ; Novartis Institutes for BioMedical Research, Emeryville, CA; Translational Clinical Oncology, Novartis Institutes for Biomedical Research, Cambridge, MA MALDI-FTICR Imaging of the Distribution of Teriflunomide in CNS Tissues in an Experimental Model of Multiple Sclerosis; Ignacy Rzagalinski ; Carola Meier ; Nadine Hainz ; Thomas Tschernig ; Dietrich Volmer ; Saarland University, Saarbrücken, Germany Multimodal Mass Spectrometry Imaging for Detection and Early Prediction of Drug Induced Phospholipidosis; Richard Goodwin ; Anna Nilsson ; Jennifer Barnes ; Julia Sampson ; Hui Zhang ; John G Swales ; Nicole strittmatter 4 ; Alan Race 5 ; Rory Steven 5 ; Logan C Mackay 6 ; Josephine Bunch 5 ; Per E Andren ; AstraZeneca, Cambridge, UK; Uppsala University, Uppsala, Sweden; AstraZeneca R&D, Mölndal, Sweden; 4 AstraZeneca, Macclesfield, Select State; 5 National Physical Laboratory, Teddington, United Kingdom; 6 University of Edinburgh, Edinburgh, United Kingdom The Evaluation of Erythroblast Dynamics in Mice Bone Marrows by MALDI FTICR-MS Imaging which Identifies 57Fe-labeled Heme Isotopic Fine Structure; Makoto Kihara ; Yukari Matsuo-Tezuka ; Keigo Yorozu ; Mitsue Kurasawa ; Hideyuki Yasuno ; Yasushi Shimonaka ; Chugai Pharmaceutical Co., Ltd, Kamakura, Japan; Chugai Pharmaceutical Co., Ltd Kamakura, Japan Large Scale, Multi-Instrument MALDI-MSI Study into Lipidosis in Inhalation Dosed Rats; Rory Thomas Steven ; Alan Race ; Aateka Patel ; Lea Ann Dailey ; Josephine Bunch, ; National Physical Laboratory, Teddington, UK; King s College London, London, UK; University of Nottingham, Nottingham, UK MALDI Imaging Mass Spectrometry of Platinum-Based Drugs in Multicellular Tumor Spheroids (MCTS) using Derivatization with Diethyldithiocarbamate (DDTC); Xin Liu ; Amanda B Hummon ; University of Notre Dame, Notre Dame, Indiana Visualization of Small Molecule and Nanoparticle Anticancer Agents in Tissue and Tumor Sections using IR-MALDESI Mass Spectrometry Imaging; Mark Bokhart ; Allison Schorzman ; Andrew Lucas ; Michael Berens ; Harshil Dhruv ; William Zamboni ; David C Muddiman ; North Carolina State University, Raleigh, NC; UNC - Chapel Hill, Chapel Hill, NC; Translational Genomics Research Institute, Phoenix, AZ Tissue Distribution of Compound X and its Metabolites in Jck Mouse Polycystic Kidneys using Mass Spectrometry Imaging (MSI); Hanlan Liu ; Cristina Silvescu ; Mandy Cromwell ; Kelly Keefe ; Lindsay Quigley ; Sirimas Sudsakorn ; Sarah Nsereko ; Yang Guo ; Laurie Smith ; Thomas Natoli ; Dinesh Bangari 4 ; Gregory Hamm 5 ; Aurore Tomezyk 5 ; Raphael Legouffe 5 ; David Bonnel 5 ; Jonathan Stauberand 5 ; Thomas O Shea ; Drug Metabolism and Pharmacokinetics, Sanofi, Waltham, MA; Rare Disease Pharmacology, Sanofi, Waltham, MA; Rare Renal Disease Research, Sanofi,, Framingham, MA; 4 Pathology, Sanofi, Framingham, MA; 5 ImaBiotech, MS Imaging Dept. Loos, France Visualizing Anti-Retroviral Distribution in Sheep and Human Vaginal Tissue by Imaging Mass Spectrometry; Michelle Reyzer ; Mark Marzinke ; Trevelyn Olive ; Richard Pyles ; Kathleen L Vincent ; Manjula Gunawardana 4 ; John Moss 4 ; Marc M. Baum 4 ; Richard M Caprioli ; Vanderbilt University, Nashville, TN; Johns Hopkins University, Baltimore, MD; University of Texas Medical Branch at TP 6 TP 6 Galveston, Galveston, TX; 4 Oak Crest Institute of Science, Monrovia, CA MALDI IMS in Drug Development: Shedding New Light on Toxicology; M. Reid Groseclose ; Stephen Castellino ; GlaxoSmithKline, Upper Merion, PA Complementary Elemental And Molecular Mass Spectrometry Imaging to Investigate 5-aminolevulinic Acid, Protoporphyrin IX and Heme Distribution in Human Brain Tumor; Sabrina Kröger ; Ann-Christin Niehoff ; Uwe Karst ; University of Münster, Institute of Inorganic and Analytical Chemistry, Münster Informatics: Peptide ID and Quantification 64-9 TP 64 Resolving Complex Glycopeptide Fragmentation Tandem Mass Spectrum; Aiying Yu ; Lauren Zacharias ; Rui Zhu ; Kerry Wooding ; Yehia Mechref ; Texas Tech University, Lubbock, Texas TP 65 Recycling Modification Site Information for Improved Glycopeptide Analysis; Robert Chalkley ; Peter R Baker ; UCSF, San Francisco, CA TP 66 Decoding Histone Post-translational Modifications by Bottom-up Mass Spectrometry; Zuo-Fei Yuan ; Simone Sidoli ; Shu Lin ; Xiaoshi Wang ; Natarajan V Bhanu ; Benjamin A Garcia ; University of Pennsylvania, Philadelphia, PA TP 67 Peak Annotation of High Resolution Spectra for Constructing Peptide Mass Spectral Libraries; Xiaoyu Yang ; Pedatsur Neta ; Yuri Mirokhin ; Dmitrii Tchekhovskoi ; Yuxue Liang ; Zheng Zhang ; Sergey Sheetlin ; Sanford Markey ; Stephen Stein ; NIST, Gaithersburg MD TP 68 A New Hope for Label Free Proteomics: moff for Opensource, Platform-independent, Automated MS Intensity Extraction; andrea argentini,, ; Kenneth Verheggen,, ; Lennart Martens,, ; Medical Biotechnology Center, VIB, Gent, Belgium; Department of Biochemistry, Ghent University, Gent, Belgium; Bioinformatics Institute Ghent, Ghent University, Gent, Belgium TP 69 Interconversion of Peptide Spectral Libraries between itraq and TMT Labels; Zheng Zhang ; Xiaoyu Yang ; Yuri A Mirokhin ; Dmitrii V Tchekhovskoi ; Weihua Ji ; Sanford P Markey ; Jeri Roth ; Deniz BaycinHizal ; Michael Bowen ; Stephen E Stein ; NIST, Rockville, MD; MedImmune, Gaithersburg, MD TP 70 Employing Complementary Ions for Deconvolution of Mixture Tandem Mass Spectra; Vladimir Gorshkov ; Stéphanie Yuki Kolbeck Hotta ; Thiago Verano-Braga, ; Frank Kjeldsen ; University of Southern Denmark, Odense, Denmark; Federal University of Minas Gerais, Belo Horizonte, Brazil TP 7 Combination of MS/HCD and MS/CID Improves Peptide IDs in Addition to Reducing the Precursor Interference of TMT-quantitation Experiment; Wen Yu ; Raghothama Chaerkady ; Deniz Baycin-Hizal ; Mathew Woodward ; Michael A Bowen ; MedImmune, Gaithersburg, MD - Maryland; MedImmune, Cambridge, UK TP 7 The Benefits of Recycling Protein Prospector: the Eco-Friendly Search Engine; Peter R Baker ; Juan A Oses ; Robert J Chalkley ; UCSF, Rokietnica; UCSF, San Francisco, CA TP 7 Evaluating Software for Precursor Ion Chromatograms in Label-Free Data-Dependent Acquisition Sets through Differentiation, Quantification, and Clustering; Yasset Perez-Riverol ; Chao Liu ; Bridget Calder ; Suereta Fortuin ; Alexander Giddey ; Birgit Schilling 4 ; David Lee Tabb 5 ; EMBL-EBI, Hinxton, UK; Institute of Computing Technology, CAS Beijing, CHINA; University of Cape Town, Cape Town, ZA; 4 Buck Institute for Research on Aging, Novato, CA; 5 Stellenbosch University, Liberty, MO PAGE 0 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

111 TUESDAY POSTERS TP 74 TP 75 TP 76 TP 77 TP 78 TP 79 TP 80 TP 8 TP 8 TP 8 TP 84 Identification of Host Cell Protein Impurities using Spectral Libraries; Meghan Burke ; Yuxue Liang ; Kelly H. Telu ; Jenny Heidbrink Thompson ; Chris Larkin ; Stephen Stein ; National Institute of Standards and Technology, Gaithersburg, MD; MedImmune, Gaithersburg, MD Negative Electron Transfer Dissociation Fragmentation in a Full-Featured Proteomics Search Engine; Yong J Kil ; Wilfred Tang ; Nicholas M Riley ; Michael S Westphall ; Joshua J Coon ; Marshall W. Bern ; Protein Metrics, San Carlos, CA; Protein Metrics, Palo Alto, CA; University of Wisconsin Madison, Madison, Wisconsin Fast and Comprehensive Peptide Identifications through Index-based Database Search; Andy Kong ; Felipe de Veiga Leprevost ; Alexey I Nesvizhskii ; University of Michigan, Ann Arbor, MI A Graph-Centric Approach for Metagenome-Guided Peptide Identification in Metaproteomics; Sujun Li ; Yuzhen Ye ; Haixu Tang ; Indiana University, Bloomington, IN Large Scale Silac Based Quantitative Analysis of Electron Accepter Stressed Azospira Suillum PS using Retention and Drift Time Profiling; Anthony T Iavarone ; Matthew D Youngblut ; Emilie Gios ; Michael Daly ; Hans K Carlson ; Ulla N Andersen ; Johannes PC Vissers ; John D Coates ; UC Berkeley, Berkeley, California; Waters, Inc. Pleasanton, CA; Waters, Wilmslow, United Kingdom PGA: an R Package for Identification of Novel Peptides by Customized Database Derived from RNA-Seq; Bo Wen ; Shaohang Xu ; Ruo Zhou ; Bing Zhang ; Wang Xiaojing ; Xin Liu ; Xun Xu ; Siqi Liu ; BGI-Shenzhen, Shenzhen, China; Vanderbilt University School of Medicine, Nashville, TN The SysteMHC Atlas Project: toward a First Mass Spectrometry-based Draft of the Human Immunopeptidome; Witold Wolski ; Etienne Caron ; Heiko Schuster; Michal Bassani-Sternberg ; Lorenz Blum 4 ; Christian Panse 5 ; Ruedi Aebersold ; Ralph Schlapbach 5 ; FGCZ ETH Zurich, Zürich, Not US or Canada; Institute of Molecular Systems Biology ETH Zurich, Zurich, Switzerland; UNIL/CHUV Ludwig Cancer Research Center Lausanne, Switzerland, Lausanne, Switzerland; 4 ETH Zurich, Zürich, Switzerland; 5 FGCZ, Univ Zurich Zurich, Switzerland An Approach to Explore Millions of Unidentified MS/ MS Peptide Features with Network Modeling and Its Implication for In-depth Proteomics; Paul E Abraham ; John C Cushman ; Daniel Jacobson ; Robert L Hettich ; Richard J Giannone ; Oak Ridge National Laboratory, Oak Ridge, TN; University of Nevada, Reno, Reno, NV Should We Care about Peptide Co-elution? ; Jamie Sherman ; Stephen Tate ; SCIEX, Concord ON, Canada Solving the no-enzyme Problem in MHC-peptide immuno-precipitation Database Searches; Patrick Murphy ; Konda Prathyusha ; Clements Derek ; Heiko Schuster ; Daniel Kowalewski ; Brian Erickson ; Joao Paulo ; Alejandro Cohen 4 ; Steven P Gygi ; Stefan Stevanovic ; Shashi Gujar ; Patrick Lee ; Dalhousie University Dept of Microbiology and Immunology, Halifax, Canada; University of Tuebingen, Tuebingen, Germany; Harvard Medical School, Boston, MA; 4 Dalhousie University, Department of Chemistry Halifax, Canada New Calibration and Absolute Quantification Features in Skyline; Nicholas Shulman ; Clark Henderson ; Birgit Schilling ; Will J Thompson ; Christopher M Shuford 4 ; Andy Hoofnagle ; Michael J MacCoss ; Brendan MacLean ; University of Washington, Seattle, WA; Buck Institute for Research on Aging, Novato, CA; Duke University, Durham, NC; 4 Center for Esoteric Testing, Burlington, NC TP 85 TP 86 TP 87 TP 88 TP 89 TP 90 TP 9 TP 9 TP 9 TP 94 De novo Sequencing of Peptides from High-resolution Bottom-up Tandem Mass Spectra using Top-down Intended Methods; Kira Vyatkina, ; Lennard J.M. Dekker ; Si Wu 4 ; Martijn M. Vanduijn ; Xiaowen Liu 5, 6 ; Nikola Tolic 7 ; Theo M. Luider ; Ljiljana Pasa-Tolic 7 ; Pavel A. Pevzner 8 ; Saint Petersburg State University, St Peterburg, Russian Federation; Saint Petersburg Academic University, St Petersburg, Russia; Erasmus Medical Center, Rotterdam, The Netherlands; 4 University of Oklahoma, Dept. of Chem & Biochem Norman, OK; 5 Indiana University-Purdue University Indianapolis, Indianapolis, IN; 6 Indiana University School of Medicine, Indianapolis, IN; 7 Pacific Northwest National Laboratory - PNNL, Richland, WA; 8 University of California, San Diego La Jolla, CA Advanced XIC-based Label-free Algorithm for High- Resolution Data; Sung Kyu Robin Park ; Rohan Rampuria ; Khatereh Motamedchaboki ; Jolene Diedrich ; Claire Delahunty ; John R Yates ; The Scripps Research Institute, San Diego, CA; The Scripps Research Institute, La Jolla, CA; Sanford-Burnham Medical Research Institute, La Jolla, CA Pros and Cons of Large Scale MS/MS Clustering - Are We There Yet?; Benjamin Pullman, ; Nuno Bandeira,, ; Center for Computational Mass Spectrometry, University of California San Diego, La Jolla, CA; Computer Science and Engineering, University of California San Diego, La Jolla, CA; Skaggs School of Pharmacy, UC San Diego La Jolla, CA Combining RNA-Seq Proteogenomics and Global Post- Translational Modification (G-PTM) Search Strategy to Reveal Human Proteomic Variation; Anthony J Cesnik ; Michael R Shortreed ; Gloria M Sheynkman ; Brian L Frey ; Lloyd M Smith ; Department of Chemistry, University of Wisconsin-Madison, Madison, WI A New Database Format to More Closely Examine Protein Splice Forms; Aparna Nathan ; Waltraud Mair ; Jan Muntel ; Hendrik Wesseling ; Judith Steen ; Hanno Steen ; Boston Children s Hospital, Boston, MA Challenges and Solutions When using OpenMS LFQProfiler Node in Proteome Discoverer. for Feature Comparison in Very Large Datasets; Jana Moerbe Rocker ; Lindsay Schambeau ; Lewis K Pannell ; University of South Alabama, Mobile, AL New Method for Label-free Quantification in the Proteome Discoverer Framework; David Horn ; Torsten Ueckert ; Kai Fritzemeier ; Carmen Paschke ; Katja Tham ; Hans Pfaff ; Xiaoyue Jiang ; Joseph Brown ; Iman Mohtashemi ; Daniel Lopez Ferrer ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Bremen, DE; Thermo Fisher Scientific, San Jose, CA Instrumentation: General 9-46 Control Software for a Spatially Multiplexed Ion Mobility- Mass Spectrometer; Babatunde H. Bello, ; Katrina L. Leaptrot, ; Jody C. May ; John A. McLean, ; Department of Mechanical Engineering, Vanderbilt University, Nashville, TN; Department of Chemistry, Vanderbilt University, Nashville, TN; VIIBRE, Vanderbilt University, Nashville, TN Real-Time Instrument Control of the Orbitrap Tribrid Mass Spectrometer; Derek J Bailey ; Florian Grosse- Coosmann ; Manish Doshi ; Qingyu Song ; Jesse D Canterbury ; Qiming Wan ; Michael Senko ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Bremen, DE High-Sensitive MCP-based Ion Detector for Time of Flight Mass Spectrometry using Triode Structure; Masahiro Hayashi ; Tetsuya Matsushita ; Joji Sakakiyama ; Akio Suzuki ; Toshiyuki Uchiyama ; Yasuhide Naito ; 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

112 GENERAL TUESDAY INFORMATION POSTERS TP 95 TP 96 TP 97 TP 98 TP 99 TP 400 TP 40 TP 40 TP 40 TP 404 TP 405 TP 406 TP 407 TP 408 Hamamatsu Photonics K.K., Iwata, Japan; GPI, Hamamatsu, Japan Improved Detection Efficiency of a High Dynamic Range Pulse Counting Detection System; Bruce Collings ; Martian Dima ; Pascal Martin ; Stephen Bruce Locke ; SCIEX, Concord, ON Highly Charge-sensitive Device to Enhance the Direct Detection of Molecular Ions; Szu-Wei Chou ; Yao-Hsin Tseng ; Liang-Chun Fan ; Yi-Kun Lee ; Chun-Yen Cheng ; AcroMass Technologies, Inc. Taipei, Taiwan A New Method for Measuring Detector Operating Life Performance; Toby Shanley ; Clifton Chey ; Russell Jurek ; Kevin L Hunter ; Peter Raffin ; Daen Ekers ; Wayne Sheils ; ETP Ion Detect, Clyde, Australia A Method for Controlling Collective Electron Motion in Ion Detectors by Locally Manipulating Magnetic Fields; Toby Shanley ; Russell Jurek ; Yair Benari ; Dick Stresau ; Kevin L Hunter ; ETP Electron Multipliers, Clyde, Australia Combined Fast Mode and Polarity Switching for Analysis of a Range of Vitamins and Nutritional Supplements in a Single Injection; Lisa Cousins ; Heather Gamble ; Charles Joliffe ; Joshua Ye ; Jason Cournoyer ; Ionics, Bolton, Canada; PerkinElmer, Waltham, MA Evaluation of RF-phase during Photoionization on the Trapping and Ejection of Ions from a D Ion Trap; Laura Bailey ; Matthew R. Bell ; Nicolas C Polfer ; University of Florida, Gainesville, FL Implementation of Ultraviolet Photodissociation using Light Emitting Diodes (LEDs) in an Ion Trap; Dustin D Holden ; Alexander Makarov ; Jae C Schwartz ; James D Sanders ; Eugene Zhuk ; Jennifer S Brodbelt ; University of Texas at Austin, Austin, TX; Thermo Fisher Scientific, Bremen, DE; Thermo Fisher Scientific, San Jose, CA Improving the Performance of a Wysocki SID Cell for Synapt HDMS; Mehdi Shirzadeh ; David H Russell ; Texas A&M, College Station, TX ECD Analysis of Serine Phosphorylated Peptides using EMS Cell; Valery G. Voinov ; Yury V Vasil ev ; Douglas F Barofsky ; Joseph Beckman ; Linus Pauling Institute, Oregon State University Corvallis, OR; Oregon State University, Department of Chemistry Corvallis, OR Up Front CID in a Laminar Flow Ion Guide for Performance Enhancement in Biological Samples; Charles Joliffe ; Shah Joshua Ye ; Heather Gamble ; Devanand Pinto ; Andrew Leslie ; Ionics, Bolton, Canada; National Research Council of Canada, Halifax, Canada Design and Modeling of a Long Distance Low Vacuum Ion Transfer System; Roman Levin, ; Evgeny Zhvansky, ; Vasily Eliferov, ; Igor Popov, ; Alexey Boldyrev ; Gleb Vladimirov ; Eugene Nikolaev ; Moscow Institute of Physics and Technology, Dolgoprudny Moscow Oblast, Russia; Institute for Energy Problems of Chemical Physics, Moscow, Russia; Institute for Energy Problems of Chemical Physics, Moscow, Russian Federation Efficient Ion Transmission and Desolvation Enabled by Vorticial Flow in DRy Ion Localization and Locomotion (DRILL) MS interface; Jung Lee ; Peter Kottke ; Elizabeth S Hecht ; David C Muddiman ; Nagender Panyala ; Matthew Torres ; Andrei Fedorov ; Georgia Institute of Technology, Atlanta, GA; NC State University, Raleigh, NC A Mass Selective Transfer Line for Injecting Ions in a Uniform Supersonic Flow; Baptiste Joalland ; Ludovic Biennier ; Sophie Carles ; Alexander Lekkas ; Dimitris Papanastasiou ; Emmanuel Raptakis ; Institut de Physique de Rennes, CNRS - Université de Rennes, Rennes, FR; Fasmatech, Athens, Greece Ion Transport through Zirconia Capillaries; J. A. Jarrell; Waters Corporation, Milford, MA TP 409 TP 40 TP 4 TP 4 TP 4 TP 44 TP 45 TP 46 Development of Ultra-High Resolution Biological Target Characterization Mass Spectrometry Instrumentation; Raul Villacob ; Paolo Benigni ; Francisco Fernandez-Lima ; Florida International University, Miami, FL Coupling Raman Spectroscopy with Laser Desorption- Atmospheric Pressure Chemical Ionization/Mass Spectrometry (LD-APCI/MS) for Polymer Analysis; Yen- Ting Chen ; Siou-Sian Jhang ; Jentaie Shiea ; National Sun Yat- Sen University, Kaohsiung, Taiwan Thermogravimetric Analyzer Coupled with Atmospheric Pressure Chemical Ionization/Mass Spectrometry (TGA- APCI/MS) to Characterize Polymers in Biodegradable Plastics Materials; Yao Sheng Zhang ; Sheng Hui Chiu ; Ming Chen ; Siou Sian Jhang ; Jentaie Shiea ; National Sun Yat- Sen University, Kaohsiung, Taiwan Fully Automated Analysis Platform for the Routine Determination of Immunosuppressants in Whole Blood; Davide Vecchietti ; Maura Brambilla ; Daisuke Kawakami ; Taku Tsukamoto ; Paolo Brambilla ; Shimadzu, Milan, Lombardy; Desio Hospital, Toxicology and Mass spectrometry department, Desio, Italy; Shimadzu Corporation, Kyoto, Japan Automated Bottom-up Proteomics Workflow for Liquid AP-MALDI MS/MS Utilising Multiply Charged Ions; Pavel Ryumin ; Jeff Brown, ; Michael Morris ; Rainer Cramer ; University of Reading, Reading, United Kingdom; Waters, Wilmslow, United Kingdom A New Conjoined RF Ion Guide for High Efficiency Ion Transmission; Daniel Kenny ; David Gordon ; Kevin Giles ; Waters, Wilmslow, United Kingdom Performance Monitoring and Quadrupole Maintenance of a First Generation Q Exactive Orbitrap in a Core Facility Setting; John Leszyk ; Scott A Shaffer ; UMass Medical School, Shrewsbury, MA Building a Next-Generation Platform for Electron-ion Optics Simulations; Russell Jurek, ; Kevin L Hunter ; ETP Ion Detect, Clyde, Australia; ETP Ion Detect, Clyde, Australia; ETP Ion Detect, Clyde, Australia Instrumentation: New Developments in Mass Analyzers TP 47 Development and Characterization of an FT-QIT with in situ Electron Ionization for Residual and Trace Gas Analysis; Yessica Brachthaeuser ; David Mueller ; Hendrik Kersten ; Klaus Brockmann ; Thorsten Benter ; Valerie Derpmann ; Alexander Laue ; Ruediger Reuter ; Michel Aliman ; Bergische Universität Wuppertal, Wuppertal, Germany; Carl Zeiss SMT GmbH, Oberkochen, Germany TP 48 Study of Directional Ion Ejection in an Asymmetric Half- Round Rod Electrode Linear Ion Trap Mass Analyzer; Zhang Zaiyue ; Yuan Guangzhou ; Qian Jie ; He Yang ; Yao Rujiao ; Zhang Shuguang ; Xiaoxu Li ; Soochow University, Suzhou, China TP 49 Optimization of the Mesh-electrode Linear Ion Trap Performance by Simulations; Qiankun Dang ; Gary Glish ; Chuan-Fan Ding ; Fudan University, Shanghai, Shanghai; University of North Carolina at Chapel Hill, Chapel Hill, NC; Fudan University, Shanghai, China TP 40 Improvement of Mass Resolution,Collision Induced Dissociation Efficiency and Low Mass Cutoff by Octopole Field in Linear Ion Trap Mass Analyzer; Chuan-Fan Ding ; Fuxing Xu ; Xinhua Dai ; Xiang Fang ; Fudan University, Shanghai; Fudan University, Shanghai, China; National Institute of Metrology, Beijing, China TP 4 Design and Analytical Performance Evaluation of a Cooling Cell for a Quadrupole Mass Spectrometer with Enhanced Resolution and Sensitivity; Tsung-Chi Chen ; Philip M Remes ; Raman Mathur ; Paul H Gregory ; PAGE 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

113 TUESDAY POSTERS TP 4 TP 4 TP 44 TP 45 TP 46 TP 47 TP 48 TP 49 TP 40 Pascual Cardenas ; Rexford T Heller ; Qingyu Song ; Viatcheslav V Kovtoun ; Satendra Prasad ; Hoa D Truong ; Eloy R Wouters ; Hans Schweingruber ; Eric C Hemenway ; Jae C Schwartz ; Terry N Olney ; Alan E Schoen ; Thermo Fisher Scientific, San Jose, CA Effects of Hexapole Electric Fields on the Performance of Linear Ion Trap Mass Analyzer; Fuxing Xu ; Xinhua Dai ; Xiang Fang ; Yuanyuan Wang ; Chuan-fan Ding ; Fudan University, Shanghai, China; National Institute of Metrology,, Beijing, China Reducing Space Charge Effects in a Linear Ion Trap by Rhombic Ion Excitation and Ejection; Lili Hu ; Xiaohua Zhang ; Yuzhuo Wang ; Dan Guo ; Wei Xu ; Beijing Institute of Technology, Beijing, China; Fudan University, Shanghai, China; National Institute of Metrology, Beijing, China Ion Collision Cross Section Analyses in Quadrupole Ion Traps using Filter Diagonalization Method:A Theoretical Study; Ting Jiang ; He Muyi ; Guo Dan ; Zhai Yanbing ; Xu Wei ; Beijing Institute of Technology, Beijing, China Ion Trap Fourier Transform Mass Spectrometer with Induced Current Detection and Arbitrary Storage Waveforms; Michael W Schmidt ; Albrecht Brockhaus ; Stefan Butzmann ; Michel Aliman ; Alexander Laue ; University of Wuppertal, Wuppertal, Germany; Carl Zeiss SMT GmbH, Oberkochen, Germany Improved Performance of Ion Trap Mass Spectrometer with Added Octopole and Dodecapole Fields; Junichi Taniguchi; Shimadzu Corp., Soraku-gun, Kyoto Demonstration of using Isolation Waveform for Beam Type Selected-Reaction-Monitoring on a QqLIT Mass Spectrometer; Qingyu Song ; Jae C Schwartz ; Philip M Remes ; Dumitresu Dean ; Thermo Fisher Scientific, San Jose, CA Advancements in Multi Reflecting High Resolution TOF Mass Spectrometry with Folded Flight Path; Viatcheslav Artaev ; Michael Mason ; Peter A Willis ; George Tikhonov ; Yury Khasin ; Anatoly Verenchikov ; LECO Corporation, St Joseph, MI; MSC-CG, Bar, Montenegro A Study of Ion Acceleration in tightly Curved Collision Cells; Felician Muntean ; Desmond A Kaplan ; Bruker Daltonics, Inc., Billerica, MA Performance of the Orbitrap Fusion Lumos Tribrid in Single-shot Analyses of Human Samples; Guadalupe Espadas, ; Eva Borràs, ; Cristina Chiva, ; Eduard Sabidó, ; Proteomics Unit, Center for Genomic Regulation, Barcelona, Spain; Proteomics Unit, Universitat Pompeu Fabra, Barcelona, Spain TP 4 NTOF Geometry for QqTOF; Bill Loyd ; Robert E. Haufler ; SCIEX, Concord, ON; AB Sciex, Concord, ON TP 4 TP 4 TP 44 TP 45 Optimization of the Performance of Toroidal Ion Trap by Theoretical Simulation; Haiyang yang ; Chengsheng Xu ; Chuan-Fan Ding ; Fudan University, Shanghai; Fudan University, Shanghai, China A Mathematical and Simulation Study of General Toroidal Ion Trap Mass Spectrometer Devices; Robert H Jackson ; Steve Lammert ; Daniel Austin ; Karl Warnick ; Jessica HIggs ; Edgar Lee ; Instrumental Design Physics, LLC, Littleton, MA; PerkinElmer, Inc., American Fork, UT; Brigham Young University, Provo, UT Radio Frequency Trapping of Ions in a Pure Toroidal Potential Distribution; Jessica Higgs ; Brae V. Petersen ; Steven A. Lammert ; Karl F. Warnick ; Daniel E. Austin ; Brigham Young University, Provo, UT; PerkinElmer, American Fork, UT Simulation of Ion Motion in Non-Ideal Electric Fields Generated by Novel FTICR Mass Analyzers; Joshua Driver ; Andriy Kharchenko ; Jon Amster ; Univ of Georgia, Athens, GA TP 46 TP 47 TP 48 TP 49 TP 440 TP 44 TP 44 Cross-field Drift of Ions and Non-Linear ICR Cell Arrays; Sung-Gun Park ; Gordon Anderson ; James Bruce ; University of Washington, Seattle, WA; GAA Custom Engineering, LLC, Benton, WA Moving Practical Mass Spectrometry Beyond the Molecular Realm; Roland Jertz ; Claudia Kriete ; Matthias Witt ; Jochen Friedrich ; Christopher Thompson ; Michael L Easterling ; Eugene N Nikolaev 4 ; Goekhan Baykut ; Bruker Daltonic GmbH, Bremen, Germany; Bruker Daltonics Inc., Billerica, MA; Bruker Daltonic, Billerica, MA; 4 The Institute for Energy Problems of Chemical Physics Russian Academy of Sciences, Moscow, Russia A Timing Control Method to Prevent Ion Overtake in a Multi-turn Time-of-Flight Mass Spectrometer (infitof).; Miki Shinichi ; Hirofumi Nagao ; Michisato Toyoda ; MSI. Tokyo, INC., Chofu, Tokyo, Japan; Osaka University, Toyonaka, Osaka, Japan Improving m/z Resolution in Charge Detection Mass Spectrometry by Reduction of Ion Trap Energy Dependence; Joanna Hogan ; Martin F Jarrold ; Indiana University Dept. Chemistry, Bloomington, IN A Novel, Miniaturized Linear Wire Ion Trap Mass Analyzer; Qinghao Wu ; Yuan Tian ; Ailin Li ; Daniel Austin ; Richard N Zare ; Brigham Young University, Provo, Utah; Stanford University, Stanford, CA New Analysis of the Bradbury-Nielsen Gates with Space Charge as Applied to Time-of-flight Analyzers; Robert Jackson; Instrumental Design Physics, LLC, Littleton, MA Addressing the 00 Isotopologue Challenge: Orbitrap Mass Spectrometry as a Means of High-Dimension Clumped and Position-specific Isotope Analysis; John Eiler ; Johannes Schwieters ; Dieter Juchelka ; Alexander A Makarov ; Jens Griep-Raming ; California Institute of Technology, Pasadena, CA; Thermo Fisher Scientific, Bremen, DE Ion Mobility: Applications (Proteins & Peptides) TP 44 CZE-nanoESI-SLIM-IMS-MS Platform for Comprehensive, Ultrasensitive Proteome Analyses; Roza Wojcik ; Ian K Webb ; Yehia M Ibrahim ; Derek F Hopkins ; Spencer A Prost ; Randolph V Norheim ; Daniel J Orton ; Sandilya Garimella ; Liulin Deng ; Ahmed M Hamid ; Ryan T Kelly ; Erin Baker ; Richard D Smith ; PNNL, Richland, WA TP 444 TP 445 TP 446 TP 447 TP 448 Separation of Protein Conformers by High Resolution Ion Mobility-Mass Spectrometry; Urs Rohner ; Michael Groessl ; Stephan Graf ; TOFWERK, Thun, Switzerland Protein Domain Structure Influences the Collision- Induced Ejection of Small Molecule Binders: Implications for the Development of Pharmaceutical Compounds; Rachel Martini ; Joseph Eschweiler ; Brandon T Ruotolo ; University of Michigan, Ann Arbor, MI Native and Denatured Protein Structural Studies using Ion Mobility MS and Ion Activation Techniques; Ruwan Kurulugama ; George C Stafford ; Joseph Eschweiler ; Brandon T Ruotolo ; John Fjeldsted ; Agilent Technologies, Santa Clara, CA; University of Michigan, Ann Arbor, MI MS-based Epitranscriptomics: New Roles for Ion Mobility and Fragmentation Techniques; Daniele Fabris ; Rebecca D Esposito ; Jennifer Lippens ; Michael Miller ; William McIntyre ; Rebecca Rose ; The RNA Institute, University at Albany, Albany, NY; The RNA Institute, University at Albany Albany, NY Analysis of Native-Like Protein and Protein Complex Ions using Structures for Lossless Ion Manipulations (SLIM); Samuel J. Allen ; Rachel M. Eaton ; Matthew F. Bush ; University of Washington, Seattle, WA 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

114 GENERAL TUESDAY INFORMATION POSTERS TP 449 TP 450 TP 45 TP 45 TP 45 TP 454 TP 455 TP 456 TP 457 TP 458 TP 459 TP 460 TP 46 TP 46 Ion Mobility-Mass Spectrometry and Collision Induced Unfolding Rapidly Detect Subtle Differences in Antibody Glycoforms; Yuwei Tian ; Brandon T Ruotolo ; University of Michigan, Ann Arbor, MI Ion Mobility Employed as a Second Dimension Separation of Isomeric Glycoforms in Glycopeptides; Gege Xu ; Elisha Goonatilleke ; Jasmine Davis ; Mariana Barboza ; Carlito B Lebrilla ; UC Davis, Davis, CA - California Water-Mediated Dimerization of Ubiquitin Ions Captured by Cryogenic Ion Mobility-Mass Spectrometry; Kelly Servage ; David H Russell ; Texas A&M University, College Station, Texas; Texas A&M University, College Station, TX Structural Investigation and Binding Site Determination of Huntingtin Protein/Peptide-ligand Complexes by IMS-HDX-MS/MS and Molecular Dynamics Simulations; Samaneh Ghassabi Kondalaji ; Mahdiar Khakinejad ; Stephen J Valentine ; Justin Legleiter ; West Virginia University, Morgantown, WV An LC/ESI-IM-MS/MS Assay for Identification and Quantification of Host Cell Proteins in Therapeutic Monoclonal Antibodies; Catalin Doneanu ; Brad J Williams ; Ian Morns ; Andrew Borthwick 4 ; Jackson Pope 4 ; Ying-Qing Yu 5 ; Weibin Chen 5 ; Waters Corporation, Milford, MA; Waters Corporation, Beverly, MA; Waters, Necastle upon Tyne, UK; 4 Waters, Necastle upon tyne, UK; 5 Waters, Milford, MA Rapid Profiling of Cellular Extracts using Ion Mobility- Mass Spectrometry; Brett Harper ; Brooke Brown ; Touradj Solouki ; Baylor University, Waco, TX Integrating Ion Mobility Separation into Peptide Mapping for Therapeutic Protein Characterization: Qualitative and Quantitative Aspects; Ying-Qing Yu ; Liuxi Chen ; Henry Y Shion ; Weibin Chen ; Waters, Milford, MA Evaluation of Formulation-Induced Aggregation in Peptide Drug Products by IMS-MS; Elizabeth E Pierson ; Nicholas A Pierson ; Paul L Walsh ; Merck Research Laboratories, Rahway, NJ Investigation of the Interaction between Antimicrobial Peptides and Lipid Membranes Using Ion Mobility Mass Spectrometry Coupled with Isothermal Titration Calorimetry; Anqi Chen ; John W Patrick ; David H Russell ; Texas A&M, College Station, TX Monitoring Conformational Landscape of Prion Protein; Guillaume Van der Rest ; Human Rezaei ; Frederic Halgand ; Universite Paris-Sud, Orsay, France; INRA, Jouy-en-Josas, France; CNRS, Orsay, France Structural transitions of Bovine Serum Albumin Studied by IMS IMS MS; Alexander D Jacobs ; Joseph D Eschweiler ; Sugyan Dixit ; Brandon T Ruotolo ; David E Clemmer ; Indiana University, Bloomington, IN; University of Michigan, Ann Arbor, MI Characterization of Cytochrome c Intramolecular Interactions using nanoesi-hdx-tims-ms and Molecular Dynamics; Juan Camilo Molano ; Khoa Pham ; Jaroslava Miksovska ; Mark E Ridgeway ; Melvin Park ; Francisco Fernandez-Lima ; Florida International University, Miami, FL; Bruker Daltonic, Billerica, MA Effects of Chain Length on the cis/trans Isomerization Mediated Folding of Polyproline Helices; Daniel W Woodall ; Tarick J El-Baba ; David E Clemmer ; Indiana University Dept. Chemistry, Bloomington, IN Introduction of Hydrophilic Sites: How Physical Modifications Alter the Conformer Preferences of Gramicidin A; John Patrick ; David H Russell ; Texas A&M, college station, TX; Texas A&M University, College Station, TX TP 46 TP 464 TP 465 TP 466 TP 467 TP 468 TP 469 TP 470 Characterization of Kinetically Trapped Intermediates of Microperoxidase- using TIMS-MS/MS and Molecular Modeling; Jacob Porter ; Alyssa Garabedian ; Paolo Benigni ; Jaroslava Miksovska ; Francisco Fernandez- Lima ; Florida International University, Miami, FL Proline Influences the Binding of Zinc to Oxytocin; Daniel R. Fuller ; Matthew S. Glover ; DoYong Kim ; David H. Russell ; David E. Clemmer ; Indiana University, Bloomington, IN; Texas A&M University, College Station, TX Determination of the Gas-Phase Energy Landscape of Substance P by IMS-IMS-MS; Chris Conant ; David H Russell ; David E Clemmer ; Indiana University, Bloomington, IN; Texas A&M, College Station, TX Analysis of Ionic Self-Complementary Peptides by Ion Mobility Spectrometry-Mass Spectrometry; Zhichao Zhang ; Daniel R. Fuller ; Tarick John El-Baba ; David E Clemmer ; Indiana University Dept. Chemistry, Bloomington, IN Comparison of Ion Mobility and Capillary Electrophoresis Mass Spectrometry Techniques for Cysteine Connectivity Identification of Peptides Bearing Intra-Molecular Disulfide Bonds; Philippe Massonnet ; Cédric Delvaux ; Gregory Upert ; Jean R. N. Haler ; Jan Jordens 4 ; Maarten Honing 4 ; Ynze Mengerink 4 ; Johann Far ; Nicolas Gilles ; Loic Quinton ; Edwin De Pauw ; University of Liège, Liège, Liège; Laboratory of Mass Spectrometry - ULg, Liege, Belgium; CEA, DSV/iBiTec S/SIMOPRO, Gif-sur-Yvette, France; 4 DSM Resolve, Geleen, The Netherlands Using Gas Phase Conformations to Understand the Role of Solvent in Establishing Biomolecule Structure in Solution; Tarick El-Baba ; Daniel Fuller ; DoYong Kim ; Dylan Rogers ; Faizan Khan ; David A Hales ; David H Russell ; David E Clemmer ; Indiana University Dept. Chemistry, Bloomington, IN; Texas A&M, College Station, TX; Hendrix College, Conway, AR Separation of Isomers in Lipidomics and Metabolomics Experiments by High Resolution Ion Mobility-Mass Spectrometry; Michael Groessl ; Stephan Graf ; TOFWERK, Thun, Switzerland High Resolution Trapped Ion Mobility Mass Spectrometry Analysis of Isomeric Compounds; Sven W Meyer ; Peter Sander ; Alexander Harder ; Detlev Suckau ; Bruker Daltonic GmbH, Bremen, Germany LC-MS: Chromatography and Software (Part ) TP 47 Peptide Elution Rate Equation: a Novel Ideal Elution Model to Help Retention Time Prediction; Wenyuan Lu ; Xiaohui Liu ; Pengyuan Yang ; Fudan University, Shanghai, China TP 47 Evaluating Effects of Metagenome Database Quality and an Optimized LC/LC-MS/MS Approach for Obtaining Deeper Proteome Coverage of Complex Microbial Communities; Ramsunder Iyer, ; Richard J Giannone ; Rose S Kantor ; Susan T.L Harrison 4 ; Robert J Huddy 4 ; Jillian F Banfield 5 ; Robert L Hettich ; Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, TN; Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN; Department of Plant and Microbial Biology, University of California, Berkeley, CA; 4 Centre for Bioprocess Engineering Research, Department of Chemical Engineering, University of Cape Town, Cape Town, South Africa; 5 Department of Earth and Planetary Sciences, University of California, Berkeley, CA TP 47 Universal Derivatization of Metabolites for Improved Sensitivity in LC-MS; James Edwards; Saint Louis University, St Louis, MO PAGE 4 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

115 TUESDAY POSTERS TP 474 TP 475 TP 476 TP 477 TP 478 TP 479 TP 480 TP 48 TP 48 TP 48 TP 484 TP 485 TP 486 Optimization of Size Exclusion Chromatography and Atmospheric Pressure Ionization Enabling Characterization of Intact Lignin and Its Degradation Products; Anastasia Artemyeva ; Kubatova Alena ; Evguenii I. Kozliak ; University of North Dakota, Grand Forks, ND Characterization of Electrochemically Decomposed Lignin Using Liquid Chromatography-High Resolution Mass Spectrometry; Tobias Dier ; Sarah Henrikus ; Verlaine Fossog ; Rolf Hempelmann ; Dietrich A Volmer ; Saarland University, Saarbrücken, Germany Deeper Proteomics using Actively Modulated Online HILIC nrplc-hrms; Andrea Gargano, ; Martin Samonig ; Michael Woldergebriel ; Remco Swart ; Garry Corthals 4 ; Peter Schoenmakers ; VU University Amsterdam, Amsterdam, Netherlands; University of Amsterdam, Amsterdam, The Netherlands; Thermo Fisher Scientific GmbH, Germering, Germany; 4 University of Amsterdam, Amsterdam, NL Low-Temperature Mobile Phase for Peptide Trapping at Elevated Separation Temperature Prior to Nano RP- HPLC-MS/MS; Matthias Schöbinger ; Oskar-James Klein ; Goran Mitulovic ; Medical University of Vienna, Clinical Institute of Laboratory Medicine, Wien, Austria; Medical University of Vienna, KIMCL, Vienna, No State/Province Porous Graphitic Carbon Packed Capillaries for the LC- MSMS Analysis of RNA Modified Nucleosides; Robert Ross ; Peter Sarin ; Hannes Drexler ; Sebastian Leidel ; Patrick A Limbach ; University of Cincinnati, Cincinnati, OH; Max Planck Institute for Molecular Biomedicine, Munster, Deutschland Redesign of Peptide Mapping Gradients to Resolve Complex Biological Samples; Xinli Yang; Rosalind Franklin University, North Chicago, IL LC/MS/MS Method for the Determination of Tricyclic and Tetracyclic Antidepressants in Human Urine; Amber Awad ; Kendra Parker ; Lawrence Andrade ; Dominion Diagnostics, N. Kingstown, RI; Dominion Diagnostics, North Kingstown A Fast and Sensitive Chiral LC-MS/MS Assay for Ketamine and its Metabolites in Human Plasma; Michel Coutu ; Evgueni Fedorov ; Jean-François Larocque ; Simon Bourgeois ; Biotrial Bioanalytical Services, Laval, QC Proteomics Needs Better Chromatography; Evgenia Shishkova ; Alexander S Hebert ; Michael S Westphall ; Joshua J Coon ; JJ Coon Research Group, Madison, Wisconsin; University of Wisconsin-Madison, Madison, WI A Novel Approach to Studying Thiamine Kinetics: an LC/ESI-MS/MS-based Method for the Analysis of Thiamine and Derivatives in Biological Samples; Jaeah Kim ; Jason Zastre ; Michael G Bartlett ; University of Georgia, Athens, GA A Functional Group Approach to Determining the Effects of Mobile Phase Modifiers on the Negative Ion ESI Ionization Efficiency; Melanie Odenkirk ; Stephen Lucas ; Christine A. Hughey ; James Madison University, Harrisonburg, VA; James Madison University, Harrisonburg, VA A Fast LC/MS/MS Method for High Sensitivity Determination of 4 Perfluorocompounds in Textiles; Jun Xiang Lee ; Zhe Sun ; Jie Xing ; Zhaoqi Zhan ; Shimadzu (Asia Pacific) Pte Ltd, Singapore Exploring the Effects of Alternative Dynamic Exclusion Algorithms on Peptide Identification Experiments; Nina Soltero ; Graeme C McAlister ; Derek Bailey ; Vlad Zabrouskov ; Thermo Fisher Scientific, San Jose, CA TP 487 TP 488 TP 489 TP 490 TP 49 TP 49 TP 49 TP 494 TP 495 TP 496 TP 497 TP 498 Targeted Profiling of Oxylipins and Endocannabinoids in Biological Samples using the Nanoflow ionkey/ms system Method Development and Validation; Sandra Gouveia-Figueira ; Malin Linder Nording ; Umea University, Umea, SE The Simultaneous Detection of a Panel of Drugs of Abuse in Post-mortem Hemolyzed Blood Samples (n=40) by LC-ESI-laminar Flow MS/MS; Sabra Botch- Jones ; Raquel LeBlanc ; Boston University School of Medicine, Boston, MA UHPLC Optimization Study for Improved LC-MS Performance and Throughput; Martin Ruehl; Thermo Fisher Scientific, Germering, Germany A Study of the γ-radiolysis of Di-Dodecyl Di-Octyl Diglycolamide (DDODGA) using UHPLC-ESI-MS Analysis; Kristyn M Johnson ; Chistopher A Zarzana ; Gary S Groenewold ; Bruce J Mincher ; Andreas Wilden ; Holger Schmidt ; Giuseppe Modolo ; Beatrix Santiago-Schübel ; Idaho National Laboratory, Idaho Falls, ID; Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung- Nukleare Entsorgung und Reaktorsicherheit, Jülich, Germany; Forschungszentrum Jülich GmbH, Zentralinstitut für Engineering, Elektronik und Analytik, Jülich, Germany The Use of a HILIC Peptide Retention Prediction Model to Predict the Presence of Modifications in Histones; Majors Badgett ; Barry Boyes ; Ron Orlando ; The University of Georgia, Athens, GA; Advanced Materials Technology, Wilmington, DE Automation and Remote Visualization of Screening Data; David M Cox ; Burkhard Schaefer ; John Gibbons ; Viktor Iassinskii ; SCIEX, Concord, ON; BSSN Software, Darmstadt, Germany; SCIEX, Concord, ON Long Term Test on a New Four-Channel HPLC; Pengxiang Yang ; BC cha ; Terry N Olney ; John Brann ; Christopher Elicone ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Franklin, MA New Supercharging Agents for TFA-Based LC-MS of Peptides and Proteins; Michael Nshanian ; Rachel Loo ; Joseph A Loo ; University of California Los Angeles, Los Angeles; UCLA, Los Angeles, CA Matrix Effects: Do They Differ between SFC/ESI-MS and LC/ESI-MS?; Alfred Svan ; Mikael Hedeland, ; Torbjörn Arvidsson, ; Curt E Pettersson ; Uppsala University, Uppsala, Sweden; National Veterinary Institute (SVA) Dept. of Chemistry, Environment and Feed Hygiene, Uppsala, Sweden; Medical Products Agency, Uppsala, Sweden Development of a Novel Nano Separation Device for Robust and Accurate Gradient Delivery with Intelligent Diagnostics; Ole Bjeld Hørning ; Stephanie Kaspar- Schoenefeld ; Christoph Gebhardt ; Peter Aagaard Nielsen ; Alexandre Podtelejnikov ; Michael Barrett Andersen ; Nicolai H Bache ; Bruker Daltonics Scandinavia, Odense, Denmark; Bruker Daltonik GmbH, Bremen, Germany HILIC and Mixed-Mode Retention of the FluoroPhenyl Stationary Phase; Shun-Hsin Liang ; Carroll Frances ; Sharon Lupo ; Ty Kahler ; Restek Corporation, Bellefonte, PA Method and Software Workflow for Integrating Paired CE-MS and LC-MS Bottom-up Proteomics Data from SDS-PAGE Pre-fractionated Samples; Yassene Mohammed, ; Anthonius A. M. Heemskerk ; Dana Ohana ; Hans Dalebout ; André M Deelder ; Oleg Mayboroda ; Magnus Palmblad ; LUMC, Center for Proteomics and Metabolomics Leiden, NL; UVic - Genome BC Proteomics Centre, Victoria, Canada 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

116 GENERAL TUESDAY INFORMATION POSTERS TP 499 TP 500 TP 50 TP 50 TP 50 TP 504 TP 505 TP 506 TP 507 Lipids: ID and Structural Analysis LipidMatch Software: Identification of Lipids and Their Oxidation Products using Data-Dependent and Data- Independent LC-MS/MS data; Jeremy Koelmel ; Nicholas M. Kroeger ; Candice Ulmer ; Rainey Patterson ; John A Bowden ; Timothy J Garrett ; Richard A Yost ; University of Florida, Gainesville, Fl; University of Florida, Gainesville, Florida; Hollings Marine Laboratory, National Institute of Standards and Technology, Charleston, SC Integrated Software for Data Processing and Analysis in Direct Infusion Ultra-High Resolution / Accurate Mass Spectrometry Based Top-Down Lipidomics Workflows; Yasuto Yokoi ; Yukihiro Fukamachi ; David Peake ; Reiko Kiyonami ; Eileen Ryan ; Gavin E Reid ; Mitsui Knowledge Industry Co, Tokyo, Japan; Thermo Fisher Scientific, San Jose, CA; University of Melbourne, Victoria, Australia A Lipid Mass Spectral Library for Human Plasma; Paul D Hutchins ; Dain R Brademan, ; Jason W Russell, 4 ; Michael S Westphall ; Joshua J Coon,, 5 ; University of Wisconsin Madison, Madison, Wisconsin; Genome Center, University of Wisconsin, Madison, WI; Department of Chemistry, University of Wisconsin, Madison, WI; 4 Morgridge Institute for Research, Madison, WI; 5 Biomolecular Chemistry, University of Wisconsin, Madison, WI SimLipid: Software Platform for Automating Shotgun, LC-MS and MALDI-MS Based High-Throughput lipidomics; Ningombam Sanjib Meitei ; Himani Gupta ; Arun Apte ; PREMIER Biosoft, Indore, India; PREMIER Biosoft, Palo Alto, CA Structural Characterization of Membrane Glycolipids from Marine Sponge-associated Bacteria by Mass Spectrometry; Benjamin L Oyler ; Courtney E Chandler ; Fan Zhang ; Christopher J Thompson 4 ; Jeremy J Wolff 4 ; Michael L Easterling 4 ; Robert K Ernst ; Russell T Hill ; David R. Goodlett ; University of Maryland, Baltimore, Whiteford, MD; University of Maryland, Baltimore, Baltimore, MD - Maryland; University of Maryland Center for Environmental Science, Baltimore, MD - Maryland; 4 Bruker Daltonics, Billerica, MA Identification and Quantitation of Unsaturated Glycerolipids from Human Plasma using the Paternò- Büchi Reaction and Tandem Mass Spectrometry; Hilary Brown ; Yu Xia ; Purdue University, West Lafayette, IN Study and Optimization of online Paternò Büchi Reactions for Structural Analysis of Unsaturated Lipids using Mass Spectrometry; Xiaoxiao Ma, ; Pei Su ; Zheng Ouyang, ; Yu Xia ; Purdue University-Weldon School of Biomedical Engineering, West Lafayette, IN; Purdue University-Department of Chemistry, West Lafayette, IN Top-down Structural Elucidation of Gram-negative Bacterial Endotoxins by Tandem Mass Spectrometry; Mohd M. Khan ; Benjamin L Oyler ; Kelsey A. Gregg ; Robert K. Ernst ; Alan S. Cross 4 ; David R Goodlett ; University of Maryland School of Pharmacy, Baltimore, MD; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD; Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD; 4 Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD Structural Characterization of Lipid Biomarkers from Staphylococcus aureus following Microextraction for Mass Spectrometric Phenotyping; Lisa Leung ; Benjamin Oyler ; Robert Ernst ; David R Goodlett ; University of Maryland, Baltimore, MD; University of Maryland School of Pharmacy, Baltimore, MD; University of Maryland Baltimore, Baltimore, MD TP 508 TP 509 TP 50 TP 5 TP 5 TP 5 TP 54 TP 55 TP 56 TP 57 TP 58 TP 59 TP 50 N-Succinylation of L-lysyl-phosphatidylglycerol in Bacillus subtilis; Paulos Chumala ; Metin Atila ; George Katselis ; Yu Luo ; University of Saskatchewan, Saskatoon, Canada; University of Saskatchewan, Saskatoon, SK Systematic Fragmentation of Lipid A Variants by Multiple and Hybrid MS/MS Techniques; Christopher Martin Crittenden ; William Ryan Parker ; Jennifer S. Brodbelt ; University of Texas at Austin, Austin, TX In-situ Characterization of Phospholipids Mixture on Tissue Sections using Wide Ion Gate HE-CID Experiment and ASDF MS/MS Spectra; Simona Salivo ; Yuzo Yamazaki ; Peter Quinto Tranchida ; Luigi Mondello ; Omar Belgacem ; University of Messina, Messina, Italy; Shimadzu Corporation, Kyoto, Japan; Shimadzu, Kratos Manchester, United Kingdom Using MS/MS and MSn to Distinguish Cytotoxic J-series Prostaglandin Isomers Produced in Tumorigenic Keratinocytes; Robert Kobet ; Rukiyah T. Van Dross ; Allison S. Danell ; East Carolina University, Greenville, NC Conformational Atlas of 7 Classes of Sphingolipids and Glycerophospholipids Mapped by Ion Mobility- Mass Spectrometry; Katrina L. Leaptrot ; Jody C. May ; James N. Dodds ; John A. McLean ; Vanderbilt Dept. of Chemistry, Nashville, TN Differentiation of Triacylglycerol Regioisomers Using Differential Ion Mobility Spectrometry; Jinyuan Wang ; Larry J Campbell ; Paul RS Baker ; SCIEX, Redwood City, CA; SCIEX, Concord, ON Identification of Lipid Metabolites of Docosahexaenoic and Arachidonic Acids in Human Blood Using Stable Isotope Labeled Compounds; Karl R Kevala ; Mark Sanders ; Hee-Yong Kim ; National Institutes of Health, Bethesda, MD; Thermo Fisher Scientific, Somerset, NJ Identification and Characterization of Sulfolipids Found in Nitzschia palea; Larry Sallans ; Daniel Betz ; Stephen F Macha ; Edna S. Kaneshiro ; University of Cincinnati, Cincinnati, OH; University of Cincinnati, Cincinnati, OH Role of ph and Mobile Phase Modifiers on Untargeted RP LC-MS Analysis of Lipid Extracts; Elena Sokol ; David Peake ; Thermo Fisher Scientific, Hemel Heampstead, United Kingdom; Thermo Fisher Scientific, San Jose, CA Identification of Metabolites of Novel Sphingoid Bases in Sphingolipid-depleted Cells using Liquid- Chromatography Electrospray Tandem Mass Spectroscopy; Brandon M Kenwood ; Samuel Kelly ; Jingjing Duan ; Alfred H Merrill Jr ; Cameron Sullards ; Georgia Institute of Technology, Atlanta, GA Identification of a Novel Lipid Family Containing a Modified Head Group; Seetaramanjaneyulu Gundimeda ; Arunkumar Padmanaban ; Agilent technologies, bangalore, karnataka; Agilent technologies, Bangalore, India Metabolomics: Sample Preparation Influence of Sampling Techniques on Human Blood Metabolome Stability during the Long-Term Sample Storage; Kristaps Klavins ; Guido Dallmann ; Therese Koal ; Biocrates Life Science AG, Innsbruck, Austria Determination of Selectivity Influenced by Liquid- Liquid Extraction in Global Metabolomics using UHPLC-qTOF-MS; Albert Elmsjö ; Mikael Karl Robert Engskog ; Jakob Haglöf ; Torbjörn Arvidsson, ; Curt Pettersson ; Department of Medicinal Chemistry; Analytical Pharmaceutical Chemistry, Uppsala University Uppsala, Sweden; Department Medicinal Chemistry; Analytical Pharmaceutical Chemistry, Uppsala University Uppsala, Sweden; Medical Product Agency, Uppsala, Sweden PAGE 6 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

117 TUESDAY POSTERS TP 5 TP 5 TP 5 TP 54 TP 55 TP 56 TP 57 TP 58 TP 59 Widely Targeted Analysis of Hydrophilic Anionic Metabolites in Mammalian Cells by Ion Chromatography Coupled with High Resolution Mass Spectrometry; Yoshihiro Izumi ; Takahiro Suzuki ; Motokazu Kimura ; Shigeru Sakamoto ; Takeshi Bamba ; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan; Thermo Fisher Scientific Japan, Tokyo, Japan; Medical Institute of Bioregulation, Kyushu Univ. Fukuoka, Japan Systematic Assessment and Selection of Liquid and Solid-Phase Methods in the Design of Sequential Extraction Protocols for LC-MS Based Metabolomics; Dmitri Sitnikov ; Cian S Morin ; Dajana Vuckovic ; Concordia University, Montreal, Canada Super-Omics: Liquid-Liquid Extraction for Proteomics, Lipidomics and Metabolomics from a Single Sample, Towards a Method for Biopsies; Susanne Breitkopf ; Min Yuan ; Gerburg Wulf, ; John M Asara, ; Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston, MA Detection Enhancement of Small Molecules, Lipids and Peptides by Functionalizing Silicon Nanopost Arrays with Fluorous Monolayers; Heather Anderson ; Nicholas Morris ; Matthew Powell ; Trust T Razunguzwa ; Protea Biosciences, Morgantown, WV A Real-time Analysis of Brain Energy Metabolism by Micro-dialysis Linked Ion Chromatography-MS; Yuki Sugiura; Keio University, Tokyo Characterizing Temporal And Inter-Individual Functional Differences in Infant Gut Microbiome by a Metaproteomics Approach; Weili Xiong ; Michael Morowitz ; Jillian Banfield ; Robert Hettich ; Oak Ridge National Laboratory, Oak Ridge, TN; University of Pittsburgh, Pittsburgh, PA; University of California, Berkeley, CA Custom isotopic N,N-Dimethyl Leucine (idileu) Reagents Enable Absolute Quantification of Aminecontaining Metabolites and Its Application to Human Cerebrospinal Fluid; Pingli Wei ; Ling Hao ; Jingxin Wang ; Xuefei Zhong ; Lingjun Li ; University of Wisconsin Madison, Madison, Wisconsin; University of Wisconsin Madison, Madison, WI Sub-Minute, Comprehensive Metabolomics Measurements for Disease and Exposure Research; Xing Zhang ; Michelle V Romm ; Erika M Zink ; Daniel J Orton ; Yehia M Ibrahim ; Matthew E Monroe ; Justin G Teeguarden ; Thomas O Metz ; Richard D Smith ; Nichole A Reisdorph ; Erin S Baker ; Anschutz Medical Campus, University of Colorado Denver, Aurora, CO; Agilent Technologies, Santa Clara, CA; Pacific Northwest National Lab, Richland, WA Online-SPE-HILIC-ESI-MS Analysis of Redox Cofactors in Chlamydomonas Reinhardtii Algae Cells; Alexander Schriewer ; Heiko Hayen ; Institute of Inorganic and Analytical Chemistry, University of Muenster, Muenster, Germany Metabolomics: Untargeted Metabolite Profiling (Cells/Plants) TP 50 Rapid Detection of Pathogenic Amoeba in Water Distribution Systems using UPLC-MS; Zhihao Yu ; Haylea Miller ; Geoffrey Puzon ; Brian H Clowers ; Washington State University, Pullman, WA; CSIRO Land and Water, Perth, Australia TP 5 Metabolomic evaluation of conditions favoring mycotoxin production in isolates of Fusarium fungi; Mark Busman; USDA, ARS, NCAUR, BFP, Peoria, IL TP 5 TP 5 TP 54 TP 55 TP 56 TP 57 TP 58 TP 59 TP 540 TP 54 TP 54 Metabolic Phenotyping of Cell Lines by Rapid Evaporative Ionization Mass spectrometry; Emrys Jones ; Emmanuelle Claude ; James Langridge ; Fiona Henderson ; Adam W McMahon ; Zoltan Takats ; Steve Pringle ; Waters Corporation, Wilmslow, UK; Wolfson Molecular Imaging Centre, Manchester, UK; Imperial College London, South Kensington Campus London, United Kingdom Metabolomic Profiling in Pulmonary Arterial Hypertension Disease Models; David P Marciano ; Caiyun grace Li ; Jan k Hennigs ; Marlene Rabinovitch ; Michael Snyder ; Stanford University School of Medicine, Palo Alto CA, USA Non-targeted Metabolite Profiling and Antioxidant Activity of Genetically Diverse Soybean Seeds; Yongsoo Choi ; Jiuliang Xu ; Jeong-Sook Shin ; Jung-Kyung Moon ; Korea Institute of Science and Technology, Gangneung, South Korea; Korea Institute of Science and Technology, Geagneung, South Korea; National Institute of Crop Science, Cheongju-Si, Chungbuk Identification and Chemical Characterization of Marine Natural Products Using UPLC-QTof-MS Coupled to a Novel Informatics Platform; Roger G. Linington ; Kenji L. Kurita ; Jimmy Yuk ; Kate Yu ; Mark Wrona ; Giorgis Isaac ; Simon Fraser University, Burnaby, BC, Canada; Waters Corporation, Milford, MA Isotopic Ratio Outlier Analysis (IROA) Global Metabolome Interrogation of an Actinomycete Bacterium following Introduction of a Novel Pathway; Felice de Jong ; Taylor A. Lundy ; Christopher W W Beecher, ; Amy L Lane ; IROA Technologies LLC, Bolton, MA; University of North Florida, Jacksonville, FL; University of Florida, Gainesville, FL Increasing Arginine Production in C. Glutamicum by Rational Strain Design and Discovery Metabolomics: Linking HRAM QTOF Data to Biology; Frederik Walter ; Marcus Persicke ; Aiko Barsch ; Christian Ravnsborg ; Heiko Neuweger ; Matthias Szesny ; Nikolas Kessler ; Jörn Kalinowski ; Bielefeld University, Bielefeld, Germany; Bruker Daltonics Ltd, Bremen, Germany; Bruker Daltonics, Bremen, Germany Metabolite Profiling of Glyphosate Exposed Saccharomyces cerevisiae with REDIchips; Christopher George ; Haddon Goodman ; Gregory Boyce ; Protea Biosciences, Morgantown, WV Environmental Exposure to Ionizing Radiation Induces Dysbiosis in Gut Microbiome and Fecal Metabolome; Maryam Goudarzi ; Jonathan Jacobs ; Tytus Mak ; Bo-Hyun Moon 4 ; Steve Strawn 4 ; Jonathan Braun ; David Brenner 5 ; Albert Fornace Jr 4 ; Georgetown University, Washington DC, DC; UCLA, Los Angeles, CA; NIST, Rockville, MD; 4 Georgetown University, Washington, DC; 5 Columbia University, New York, NY Abiotic Stresses Influence Organic Metabolite Profiles in Soils Hosting Populus Trees and a Microbial Community; Charles J. Doktycz ; Collin M. Timm ; Keiji G Asano ; David J Weston ; Dale A. Pelletier ; Greg Hurst ; Oak Ridge National Laboratory, Oak Ridge, TN Evaluation of High Speed, High Resolution Data Independent Acquisition for the Analysis of Metabolomic Flux, Kinetics and Pathway; Loren Y Olson ; Baljit Ubhi ; SCIEX, Redwood City, CA Untargeted Metabolomics with Fungal Artificial Chromosomes (FAC-MS) Allows Discovery and Facile Dissection of Natural Product Biosynthesis; Kenneth D Clevenger ; Jin Woo Bok ; Rosa Ye ; Galen P Miley ; Thomas Velk ; Cynthia Chen ; KaHoua Yang ; Peng Gao ; Matthew Lamprecht ; Paul M Thomas ; Md Islam ; Chengcang C Wu ; Nancy P Keller ; Neil L Kelleher ; 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

118 GENERAL TUESDAY INFORMATION POSTERS TP 54 TP 544 TP 545 TP 546 TP 547 TP 548 TP 549 TP 550 TP 55 TP 55 TP 55 Northwestern University, Evanston, IL; University of Wisconsin Madison, Madison, Wisconsin; Intact Genomics, Inc, St. Louis, MO In vivo Analysis of Metabolites in Single Embryonic Cells in the Developing Frog (Xenopus)Embryo using Microcapillary-Sampling CE-ESI-MS; Erika Portero ; Rosemary M Onjiko ; Sally A Moody ; Peter Nemes ; The George Washington University, Washington, DC Eavesdropping on Marine Microbial Communication: Influence of Quorum Sensing on the Vibrio campbellii Metabolome; Gregory Ellis ; Brian J. Eddie ; Arnaldo A. Torres Padua ; W. Judson Hervey IV 4 ; Gary J. Vora 4 ; Dagmar H. Leary 4 ; National Research Council NRL Fellow, Washington, DC; American Society of Engineering Education NRL Fellow, Washington, DC; University of Puerto Rico Mayaguez, Mayaguez, PR; 4 Center for Bio/ Molecular Science and Engineering, Naval Research Laboratory, Washington, DC Untargeted -Sample-Comparison using High- Resolution Data from LC/Ion Mobility Q-TOF Mass Spectrometers via a Novel 4D Molecular Feature Extraction Algorithm; Frank Kuhlmann ; Xiangdong Li ; Ed Darland ; Agilent Technologies, Santa Clara, CA Metabolic Profiling of Strawberry Leaves Infected by Xanthomonas Fragariae using UPLC/QTOF Mass Spectrometry; Min-Sun Kim ; Geum-Sook Hwang ; Korea Basic Science Institute, Seoul, Republic of Korea; Korea Basic Science Institute, Seoul, Republic of Korea Global Metabolomics Approach to Identify Pathways Effected by Glyphosate in Yeast; Gregory Boyce ; Mark Szewc ; Protea Biosciences, Morgantown, WV Chemical Profiling of Actaea Species and Commerical Products using UPLC-QTof-MS; Jimmy Yuk ; Maged Sharaf ; Kate Yu ; Mark Wrona ; Giorgis Isaac ; Waters, Milford, MA; American Herbal Products Association, Silver Spring, MD Non-targeted Differential Screening using LC-HRAM- MS as a Tool for Evaluating Differences in Chemical Composition between Samples and Sample Groups; Daniel Arndt ; Arno Knorr ; Mark Bentley ; Philip Morris International R&D, Neuchâtel, Switzerland Non-targeted Differential Screening of Complex Matrices using GC GC-TOFMS for Comprehensive Characterization of Chemical Composition and Determination of Significant Differences; Martin Almstetter ; Arno Knorr ; Quentin Dutertre ; Elyette Martin ; Antonio Castellon ; Pavel Pospisil ; Mark Bentley ; Philip Morris International, Neuchâtel, Neuchâtel Atmospheric Pressure Gas Chromatography Mass Spectrometry (APGC-MS) Based Metabolomics Profiling of Grape Volatiles; Manoj Ghaste, ; Giuseppe Astarita ; Fulvio Mattivi ; Vladimir Shulaev ; University of North Texas, Denton, TX; Fondazione Edmund Mach, San Michele all Adige TN, Italy; Waters, Milford, MA Comparison of Direct Introduction on Orbitrap Fusion and FT-ICR at High-end Resolution for Global Metabolite Screening; Ulli Martin Hohenester, ; Pierre Barbier Saint Hilaire ; Benoit Colsch ; Francois Fenaille ; Jean-claude Tabet ; Christophe Junot ; Richard B Cole ; Commissariat à énergie atomique et aux énergies alternatives, Gif Sur Yvette Cedex, Fr; Sorbonne Universités, UPMC Univ Paris 06, Institut Parisien de Chimie Moléculaire, Paris, Fr Development of High-Performance Chemical Isotope Labeling LC-MS for Profiling Alcoholic Hydroxyl- Containing Metabolites in Metabolomics; Shuang Zhao ; Liang Li ; Department of Chemistry, University of Alberta, Edmonton, AB, Canada TP 554 TP 555 TP 556 TP 557 TP 558 TP 559 TP 560 TP 56 TP 56 TP 56 TP 564 TP 565 TP 566 TP 567 Metabolomic Profiling of Food Diets Using Ion Chromatography with High Resolution Orbitrap Mass Spectrometry; Terri Christison ; JUNHUA WANG ; Linda Lopez ; Ralf Tautenhahn ; Thermo Fisher Scientific Inc, Sunnyvale, CA; Thermo Fisher Scientific Inc, San Jose, CA; Thermo Fisher Scientific, San Jose, CA Metabolic Profiling of Bladder Cancer Cell Lines Reveals Molecular Alterations Involved in Methylation and Novel Epigenetic Phenotype; Feng Jin ; Rashmi Krishnapuram ; Franklin Gu ; Salil Kumar Bhowmik ; Suman Maity ; Mohan Manikkam ; Friedrich-Carl von Rundstedt ; Vasanta Putluri ; Yair Lotan ; Jonathan Levitt ; Seth P. Lerner ; Cristian Coarfa ; Benny Abraham Kaipparettu ; Arun Sreekumar ; Nagireddy Putluri ; Baylor College of Medicine, Houston, TX; University of Texas Southwestern Medical Center, Dallas, TX Metabolomic Signatures in Sera from Early Stage Ovarian Cancer Patients; David A Gaul ; Christina M Jones ; Tran Q Long ; John F McDonald ; Facundo M Fernandez ; Georgia Institute of Technology, Atlanta, GA Discovery of Altered Metabolic Pathways in PARPi- Resistant Ovarian Cancer; Chandra Shekar R Ambati ; Sachin Kumar Gupta ; Sajna A Vithayathil ; Suman Maity ; Laising Yen ; Benny Abraham Kaipparettu ; Cristian Coarfa ; Nagireddy Putluri ; Vivekananda Shetty ; Baylor College of Medicine, Houston, TX Nucleic Acids RNA Modification Mapping - Software Development; Ningxi Yu ; Patrick A Limbach ; University of Cincinnati, Cincinnati, Ohio Development of a Computational Algorithm to Predict Mobile Phase Additives for Optimal LC-MS Sensitivity of Oligonucleotides; Babak Basiri ; Michael G Bartlett ; University of Georgia, Athens, GA A Flow Injection Inductively Coupled Plasma Mass Spectrometry Method for Quantification of Modified Oligonucleotides; Fanyu Meng ; Qiang Tu ; Erin Guidry ; Merck & Co., Inc, Rahway, NJ; Merck, Darmstadt, Germany Comparison of Q-Tof, Q-Exactive and Triple Quad for Quantitative Bioanalysis of Oligonucleotide Therapeutics; Yuhuan Ji ; Qian Liu ; Qian Li ; Chengjie Ji ; Laixin Wang ; NovaBioAssays, LLC, Woburn, MA A Micro-SPE-LC/MS/MS Quantitative Assay for Phosphorodiamidate Morpholino Oligomer (PMOplus ) AVI-788 in HumanPlasma; Aihua Liu ; Jianbo Zhang ; Qian Guo ; Bryce Ashby ; Scott Reuschel ; Jay S. Charleston ; Joe Rutkowoski ; Min Meng ; Covance, Salt Lake City, UT; Sarepta Therapeutics, Cambirdge, MA Determination of a 5-mer Antisense Oligonucleotide in Mouse Plasma by LC-MS/MS; Lili Xing ; Ying Han ; Yi Tao ; Xinping Fang ; Xin Zhang ; WuXi AppTec Co., Shanghai, CHINA A Sensitive Liquid Chromatogram/Mass Spectrometry Method for the Determination of a Therapeutic sirna in Human Plasma; Pei Li ; Dawei Zhou ; Xinping Fang ; WuXi AppTec Co., Plainsboro, NJ LC-MS/MS-based DNA Adduct Quantification for Assessing the Etiology and Prevention of Skin Cancer; Yuxiang Cui ; Yinsheng Wang ; University of California, Riverside, Riverside, California; University of California, Riverside, Riverside, CA Differential Mass Spectrometry Analysis of Transfer RNA by Stable Isotope Labelling; Mellie Paulines ; Patrick A Limbach ; University of Cincinnati, Cincinnati, OH Evaluating the Specificity of RNase U Variants By Mass Spectrometry; Beulah Mae Ann Solivio ; Ningxi PAGE 8 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

119 TUESDAY POSTERS TP 568 TP 569 TP 570 TP 57 TP 57 TP 57 TP 574 TP 575 TP 576 TP 577 TP 578 TP 579 TP 580 Yu ; Balasubrahmanyam Addepalli ; Patrick A Limbach ; University of Cincinnati, Cincinnati, Ohio; University of Cincinnati, Cincinnati, OH Screening for Inflammation-induced DNA Adducts with a Comprehensive High Resolution LC-MS adductomic Approach; Andrea Carra ; Peter W Villalta ; Romel P Dator ; Silvia Balbo ; Masonic Cancer Center, University of Minnesota, Minneapolis, MN Identification of Isomeric Mono-Methylated Nucleosides in Ribonucleic Acids by Liquid Chromatography Highly Accurate Tandem Mass Spectrometry; Hiroshi Nakayama ; Yoshio Yamauchi ; Masato Taoka ; Toshiaki Isobe ; RIKEN Center for Sustainable Resource Science, Wako, Japan; Tokyo Metropolitan University, Tokyo, Japan Labeling trna Digestion Products using polya Polymerase and Azido-modified NTPs; Kayla Borland ; Patrick A Limbach ; University of Cincinnati, Cincinnati, OH High-Resolution/Accurate-Mass LC-MS Screening and SRM Relative Quantitation of DNA Adducts as Biomarkers of Drug Susceptibility; Alessia Stornetta ; Peter W Villalta ; Stephen S Hecht ; Silvia Balbo ; Shana J Sturla ; ETH Zurich, Switzerland, CH; Masonic Cancer Center, University of Minnesota, Minneapolis, MN Interaction of Antitumor Metallocenes with Nucleic Acids; Rahel Patricia Eberle ; Stefan Schürch ; University of Bern, Bern, Switzerland Characterization of Amino Acid-Linked Platinum Complexes and Their Adducts to RNA Using Tandem Mass Spectrometry Approaches; M. T. Rodgers ; C. C. Hech ; L. Hamlow ; Y. Zhu ; H. Roy ; S. Strobehn ; B. Kimuntai ; X. Bao ; C. S. Chow ; J. Gao ; G. Berden ; J. Oomens ; Wayne State University, Detroit, MI; FELIX Facility, Radboud University, Nijmegen, The Netherlands Monitoring the Fe(II) Driven Reduction of AMP with Triple Quadrupole Mass Spectrometry; Jacqueline N Howard ; Molly T Soper-Hopper ; Jessica C Bowman ; Ramanarayanan Krishnamurthy ; Loren Dean Williams ; Facundo M Fernandez ; Georgia Institute of Technology, Atlanta, USA; The Scripps Research Institute, La Jolla, CA RNA-small Molecule Complexes as Models for Salt Bridge and Hydrogen Bond Interactions; Jovana Vusurovic ; Kathrin Breuker ; University of Innsbruck, Innsbruck, Austria Comparative Analysis of the Fragmentation of Modified and Unmodified Oligonucleotides; Ning Li, ; Babak Basiri ; Michael G Bartlett ; University of Georgia, Chemistry Department Athens, GA; Shenyang Pharamaceutical University, Shenyang, Liaoning Mapping Eukaryotic mrna-binding Regions on Proteins using High Resolution Mass Spectrometry; Meeli Mullari ; Nielsen Lund Michael ; Novo Nordisk Foundation Center for Protein Researc, Copenhagen, Denmark Fӧrster Resonance Energy Transfer (FRET) Measurements to Probe the Conformation of Gaseous Oligonucleotide Duplexes in the Gas Phase; Stephen Sciuto ; Rebecca A Jockusch ; The University of Toronto, Toronto, ON; University of Toronto, Toronto, Ontario (ON) Mass Spectrometry-based Determination of the Complete Chemical Structure of Saccharomyces Cerevisiae Ribosomal RNAs.; Masato Taoka ; Yuko Nobe ; Yuka Yamaki ; Hideaki Ishikawa ; Yoshio Yamauchi ; Nobuhiro Takahashi ; Hiroshi Nakayama ; Toshiaki Isobe ; Department of Chemistry, Tokyo Metropolitan Univ., Tokyo, Japan; Tokyo University of Agriculture and Technology, Tokyo, Japan; RIKEN, Wako, Japan Developing Novel Integrated LC-MS Workflows for Oligonucleotide Characterization, High Throughput Mass Confirmation and Impurity Profiling; HENRY SHION ; Robert Birdsall ; Joe Fredette ; Ying-Qing Yu ; Waters Corporation, Milford, MA TP 58 TP 58 TP 58 TP 584 TP 585 TP 586 TP 587 TP 588 TP 589 On-Line Monitoring of Oligonucleotide Manufacturing Using a Compact Mass Spectrometer; Stilianos G. Roussis ; Andrew Rodriguez ; Isaiah Cedillo ; Josh Brooks ; Claus Rentel ; Ionis Pharmaceuticals, Inc., Carlsbad, CA; Ionis Pharmaceuticals, Carlsbad, CA Use of Tricationic Ion-Pairing Compounds for the Detection of Nucleotides from Single Cells; ye guan ; Rachel Vowcicefski ; Wei Rao ; Ning Pan ; Anthony Burgett ; Zhibo yang ; University of Oklahoma, department of Chemistry & Biochemistry, Norman, OK Peptides: PTM Identification Ultra-sensitive Motif-targeting Approach for Measurement of Tyrosine Phosphorylation Stoichiometry in EGFR; Yen-Chen Liao, ; Chia-Feng Tsai ; Miao-Hsia Lin ; Pei-Yi Lin ; Yasushi Ishihama ; Yu-Ju Chen, ; Institute of Chemistry, Academia Sinica, Taipei, Taiwan (R.O.C); Department of Chemistry, National Taiwan University, Taipei, Taiwan (R.O.C); Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan Subphosphoproteome Analysis Strategy to Identify Low-abundance Protein Phosphorylation; Mingliang Ye ; Mingming Dong ; Yangyang Bian ; Lei Li ; Li S.-C. Shawn ; Hanfa Zou ; Dalian Institute Chemical Physics, CAS Dalian, China; Western University, London, Canada Comprehensive Phosphoproteome Analysis Reveals Acetylation-engaged Enhancement of Thermogenesis in White Adipocytes; Hsin-Yi Chang ; Kosaku Shinoda ; Shingo Kajimura ; Yasushi Ishihama ; Department of Molecular and Cellular Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan; UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California, San Francisco, CA USA Identification of Complex Glycosylated and Disulfide- Bonded Peptides Presented by the MHC Class II Processing Pathway in Melanoma; Stacy Malaker ; Michael J Ferracane ; Florence R Depontieu ; Angela L Zarling ; Jeffrey Shabanowitz ; Dina L Bai ; Engelhard H Victor ; Suzanne L Topalian ; Donald F Hunt ; University of Virginia, Charlottesville, VA; University of Florida, Gainesville, Florida; Johns Hopkins University School of Medicine, Baltimore, MD Development of Rapid LC-MS Methodology for Indepth Structural Analysis of Lewis Antigens and Their Sialylated Derivative Isomers using Authentic Standards; Yaping Lin ; Chein-Hung Chen ; Fang-Chi Liu ; Chia-Lin Wu ; Jung-Lee Lin ; Chien-Tai Ren ; Chung-Yi Wu ; Chung-Hsuan Chen ; Academia sinica, Taipei, Taiwan; Academia Sinica, Taipei, Taiwan Sialo-glycoproteomic Profiling using Zwitter-Ionic Hydrophilic Interaction Chromatography (ZIC-cHILIC); Yu-Hsien Lin ; Yi-Ju Chen ; Yu-Ju Chen ; Academia Sinica, Taipei, Taiwan Proteome Dynamics Reveal Temporal Regulation of O-GlcNAcylation/phosphorylation in Determining Apoptosis of Activated B Cells; Hsin-Yi Wu ; Jung-Lin Wu, ; Cheng-Tsung Lu 4 ; Yi-Ju Chen 5 ; Tzong-Yi Lee 4 ; Chih- Wei Chien 5 ; Yi-Ting Wang 5 ; Chun-Cheng Lin 6 ; Kay-Hooi Khoo 7 ; Yu-Ju Chen 5 ; Kuo-I Lin ; Institute of Chemistry, Academia Sinica, Taipei, Taiwan; Genomics Research Center, Academia Sinica, Taipei, Taiwan; Institute and Department of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan; 4 Department of Computer Science and Engineering, Yuan Ze University, Taipei, Taiwan; 5 Institute of Chemistry, Academia Sinica, Taipei, TAIWAN (R.O.C.); 6 Department of Chemistry, National Tsing Hua University, Taipei, Taiwan; 7 Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9

120 GENERAL TUESDAY INFORMATION POSTERS TP 590 TP 59 TP 59 TP 59 TP 594 TP 595 TP 596 TP 597 TP 598 TP 599 TP 600 TP 60 Efficient Enrichment of SUMOylated Peptides from Alpha-lytic Protease Digest Using K- Ɛ -GG Remnant Immuno-affinity Purification; Hongbo Gu ; Xiaoying Jia ; Jian Min Ren ; Elizabeth Komives ; Matthew P Stokes ; Cell Signaling Technology, Danvers, MA; Department of Chemistry and Biochemistry, UCSD, La Jolla, CA An Improved Strategy for In-depth and Site-specific Analysis of the SUMO Proteome.; Ivo A. Hendriks ; Clifford Young ; Michael L. Nielsen ; NNF Center for Protein Research, Copenhagen, Denmark Ubiquitinated Proteins in MDSC Exosomes Analyzed by High Resolution Tandem Mass Spectrometry; Katherine Adams ; Yan Wang ; Suzanne Ostrand-Rosenberg ; Catherine Fenselau ; University of Maryland, College Park, MD; University of Maryland, Baltimore County Baltimore, MD Low Mass Ions in Peptide CID Spectra are Diagnostic of Lysine Posttranslational Modifications; Tobias Maile ; Tommy K Cheung ; Corey Bakalarski ; Marie Classon ; David Arnott ; Genentech Inc, South San Francisco, CA Quantitative Profiling of the Enzymatic Activity of the Protein Lysine Mono-methyltransferase SMYD using SILAC-based Proteomics; Jonathan B Olsen ; Xing-Jun CAO ; Bomie Han ; Lisa Hong Chen ; Alexander Horvath ; Timothy I Richardson ; Robert M Campbell ; Benjamin A Garcia ; Hannah Nguyen ; Eli Lilly and Company, Indianapolis, IN; University of Pennsylvania, Philadelphia, PA Characterizing Post-Translationally Modified Peptides by High-Resolution FAIMS Coupled to Electron Transfer Dissociation; Matthew Baird ; Alexandre A Shvartsburg ; Wichita State University, Wichita, KS Innovative Characterization of Hair from pre-hispanic Andean Mummies using Mass Spectrometry; Margaux Fresnais ; Pascale Richardin ; Marcela Sepúlveda ; Emmanuelle Leize-Wagner ; Armelle Charrié-Duhaut ; Laboratoire de Spectrométrie de Masse des Interactions et des Systèmes (LSMIS), UMR 740 CNRS-Université de Strasbourg, Strasbourg, France; Centre de Recherche et de Restauration des Musées de France (CRMF), Paris, France; Laboratorio de Análisis e Investigación Arqueométricas, Instituto de Alta Investigación, University of Tarapacá, Arica, Chile Identification and Characterization of Covalent Modification of Catechol Estrogens on Proteins ; Huei- Chen Liang ; Chieh-Ming Fang ; Ming-Chun Ku ; Shu-Hui Chen ; Chemistry Dept. NCKU, Tainan, Taiwan (R.O.C.) Comprehensive Analysis of Post-translational Modifications in Proteins Exposed to Metal Catalyzed Oxidation; Martin Rykær ; Birte Svensson ; Kim Henriksen ; Per Hägglund ; Technical University of Denmark, Kgs Lyngby, Kgs Lyngby; Technical University of Denmark, Systems biology, KGS Lyngby., DK; Nordic Bioscience A/S, Herlev, DK Quantitative Profiling of Prokaryotic Post Translational Modifications; Charles L Farnsworth ; Jian Min Ren ; Jake A Namaroff ; Xiaoying Jia ; Kimberly A Lee ; Matthew P Stokes ; Cell Signaling Technology, Danvers, MA; Cell Signaling Technology, Inc. Danvers, MA Charged Isotope Tag Improves Identification of Hydrophobic Peptide-Ligand Adducts; Melissa Budelier ; James Janetka ; Douglas Covey ; Alex Evers ; Washington University in St. Louis, St. Louis, MO Alkylamine Ion-pairing Agents for Improved Positive Mode Electrospray Ionization Analysis of Sulfated Peptides; Phillip McClory ; Kristina Hakansson ; University of Michigan, Ann Arbor, MI TP 60 TP 60 TP 604 TP 605 N-Terminal Charged-based Fractional Diagonal Chromatography (ChaFRADIC) to Study Proteolytic Events in Procoagulant Platelets; Fiorella Andrea Solari ; Saskia A. Venne ; Nadine J.A. Mattheij ; Julia M. Burkhart ; Frauke Swieringa ; Peter W. Collins 4 ; Judith M.E.M Cosemans ; Albert Sickmann ; Johan W.M. Heemskerk ; René P Zahedi ; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.v., Dortmund, Germany; Leibniz-Institut für Analyt. Wissensch. - ISAS -, Dortmund, Germany; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Maastricht, Maastricht, Netherlands; 4 Arthur Bloom Haemophilia Centre, School of Medicine, Cardiff University, Cardiff, United Kingdom Utilizing TIMS Mass Spectrometry to Resolve Competitive Isomeric Post-Translational Modifications; Joshua Silveira ; Joe Gomez ; Melvin Park ; Kristofer Fritz ; Bruker Daltonic, Billerica, MA; University of Colorado, Anschutz Medical Campus, Aurora, CO; University of Colorado, Anschutz Medical Campus, Denver, CO System-wide Analysis of the Human Arginine Methylome; Sara C. Larsen ; Kathrine B. Sylvestersen ; Andreas Mund ; Maria V. Madsen ; David Lyon ; Jeremy A. Daniel ; Lars J. Jensen ; Michael L. Nielsen ; NNF Center for Protein Research, Copenhagen, DENMARK Method Development for Complete Mutation and Posttranscriptional Modification Characterization of KRAS4b using Recombinant Proteins in Combination with LC-MS/MS; Zhaojing Meng ; William Gillette ; Stephen Andrew ; Ming Zhou ; Frederick National Laboratory for Cancer Research, Frederick, MD Phosphopeptides: Quantitative Analysis TP 606 Multiplexed Targeted Analysis of Post-translational Modifications: Robust and Reproducible Quantitation using isobaric Labels and MS Analysis; Brian Erickson ; Robert A Everley ; Christopher M Rose ; Alison R Erickson ; Steven P Gygi ; Harvard Medical School, Boston, MA TP 607 Comparative Phosphoproteomic Analysis of Hippocampal Tissue in a Non-Human Primate Model of Type Diabetes Maintained with Exogenous Insulin; Fang-Ke Huang ; Jose Morales-Corraliza, ; Paul M. Mathews, ; Thomas A. Neubert ; Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York City, NY; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY; Department of Psychiatry, New York University Langone Medical Center, New York City, NY TP 608 Large-scale Targeted Analysis of Post-translational Modifications by Internal Standard-Triggered Parallel Reaction Monitoring: Application to Determination of Phosphorylation Site Occupancy; Bruno Domon ; Sara Rosati ; Adele Bourmaud ; Sebastien Gallien ; Luxembourg Clinical Proteomics Center, Strassen, Luxembourg TP 609 Global Phosphoproteomics of Targeted Combinatorial Therapy in Hepatocellular Carcinoma to Identify Molecular Signatures of Effective Therapy; Joseph Capri ; Whitaker Cohn ; Thuc Le ; Kym F Faull ; Julian P Whitelegge ; UCLA, Los Angeles, CA TP 60 Quantitative Analysis of the Cdk-dependent Phosphoproteome in S. Pombe using SILAC and Tandem Mass Tags; Andrew W Jones, ; Matthew Swaffer ; Jenny T.C Ho ; Helen Flynn ; Paul Nurse ; Gary Woffendin ; Madalina Oppermann ; Ambrosius P Snijders ; Proteomics Technology Platform, The Francis Crick Institute, London, UK; Cell Cycle Laboratory, The Francis Crick Institute, London, UK; Thermo Fisher Scientific, Hemel Hempstead, Hemel Hempstead, UK PAGE 0 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

121 TUESDAY POSTERS TP 6 TP 6 TP 6 TP 64 TP 65 TP 66 TP 67 TP 68 TP 69 TP 60 Phosphoproteome Analysis Reveals Rapid Reprogramming of Signaling Networks of Drug Treated Cancer Cells; Heiner Koch,, ; Melanie Schoof ; Benjamin Ruprecht ; Susan Klaeger ; Scarlet Beck 4 ; Martin Frejno, 5 ; Mathias Wilhelm ; Hannes Hahne 6 ; Bernhard Kuster,,, 7 ; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany; German Cancer Consortium (DKTK), Muenchen, Germany; German Cancer Research Center, Heidelberg, Germany; 4 Max Planck Institute for Biochemistry, Martinsried, Germany; 5 Oxford University, Oxford, United Kingdom; 6 OmicScouts GmbH, Freising, Germany; 7 Center for Integrated Protein Science, Munich, Germany Effect of Exercise on Skeletal Muscle Phosphoproteome in Obese Insulin Resistant Adults; Danjun Ma ; Lisa Guth ; Yue Qi ; Michael Caruso ; Xiangmin Zhang ; Jeffrey Horowitz ; Zhengping Yi ; Wayne State University, Detroit, MI; University of Michigan, Ann Arbor, MI Quantitative Phosphoproteomic Analysis of Circadian Cycling in Genetically Modified Arabidopsis; Jae Choi ; Jenny Chen ; John D Rogers ; Dmitri A Nusinow ; Bradley S Evans ; Thermo Fisher Scientific, Rockford, IL; Thermo Fisher Scientific, San Jose, CA; Donald Danforth Plant Science Center, St Louis, MO Differential Mass Spectrometry Analysis Reveals Differential Hypoxic Response in Ovarian Cancer Cells with Different Metastatic Potential; Xuemei Zeng ; Huang Huang ; Xin Huang ; Nathan A Yates ; University of Pittsburgh, Pittsburgh, PA Rapid Quantitative Phosphoproteome by Tandem Mass Tags; Haiyan Tan ; Bing Bai ; Xusheng Wang ; Yuxin Li ; Ji- Hoon Cho ; Tim Shaw ; Junmin Peng ; St.Jude Children s Research Hospital, memphis, TN; St Jude Children s Research Hospital, Memphis, TN High Throughput Multiplexed Phosphoproteomics Identifies Drivers of Resistance to ALK Inhibitor Treatment in Lung Cancer; Amanda L. Edwards, ; Luc Friboulet, ; Rosa Frias, ; Kristine Yu ; David Ruddy ; Jeffrey A. Engelman, ; Wilhelm Haas, ; Massachusetts General Hospital Cancer Center, Charlestown, MA; Harvard Medical School, Boston, MA; Translational Clinical Oncology, Novartis Institutes for Biomedical Research, Cambridge, MA Inferring Kinase Network Activity from Activation-loop Phosphopeptides by Data-Independent Acquisition MS; Sander Piersma ; Richard R de Haas ; Jaco C Knol ; Thang V Pham ; Henk MW Verheul ; Connie R Jimenez ; VU University medical center, Amsterdam, The Netherlands Prediction of Protein Kinase Substrates using Primary Sequence Preference and Quantitative Phosphoproteomics; Haruna Imamura ; Pasrawin Taechawattananant ; Omar Wagih ; Naoyuki Sugiyama ; Pedro Beltrao ; Yasushi Ishihama ; Kyoto University, Kyoto, Japan; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, Cambridge, United Kingdom Absolute Quantitation of Site-specific Phosphorylation of Insulin Receptor by A Nano UPLC-MS Method; Zhongping Liao ; Kyoung-soo Choi ; Jason X Tang ; Eli Lilly and Company, Indianapolis, IN Evaluation of Search Engines for Phosphopeptide Identification and Quantitation; Xiaoyue Jiang ; David M Horn ; Ryan D Bomgarden ; Tara Schroeder ; Rosa I Viner ; Andreas Huhmer ; Steven Danielson 4 ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Rockford, IL; Thermo Fisher Scientific, Somerset, NJ; 4 Thermo Fisher, San Jose, CA TP 6 TP 6 TP 6 Dimethylated Alanine (DiAla)-assisted Largescale Protein Phosphorylation Stoichiometry Characterization; Qing Yu ; Yu Feng ; Lingjun Li ; University of Wisconsin-Madison, Madison, Wisconsin; University of Wisconsin-Madison, Madison, WI High Resolution-Enabled -plex DiLeu Tagging for Quantitative Phosphoproteomics Profiling of Vascular Smooth Muscle Cells; Xiaofang Zhong ; Christopher Lietz ; Xudong Shi ; Amanda Buchberger ; Dustin Frost ; Craig Kent ; Lingjun Li ; University of Wisconsin-Madison, Madison, WI Sensitive and Accurate Quantitation of Phosphopeptides using TMT Isobaric Labeling Technique; Xiaoyue Jiang ; Ryan D Bomgarden ; Rosa I Viner ; Andreas Huhmer ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Rockford, IL Proteins: Complexes/Non-covalent Interactions TP 64 Using Native MS to inform Statistical Thermodynamic Models of Cooperativity; Melody Pepsi Holmquist ; Elihu C Ihms ; Vicki H Wysocki ; Mark P Foster ; Ohio State University, Columbus, OH TP 65 Native MS analysis of chemically stabilized protein complexes: evidence for non-covalent stabilization of protein-protein interactions; Roman Subbotin ; Dominic Paul B Olinares ; Julio C Padovan ; Megan Kelley ; Zheng Ser ; Brian T Chait ; The Rockefeller University, New York, NY TP 66 Probing Nucleotide-dependent Changes in the Oligomeric State of MORC Proteins using Native Mass Spectrometry; Jonathan Johnston ; Linda Yen ; Steven E Jacobsen ; Alma L Burlingame ; UCSF, San Francisco, CA; UCLA, Los Angeles, CA TP 67 Characterization of a Protein-DNA Complex by Native Mass Spectrometry and Ultraviolet Photodissociation; Jake Rosenberg ; Alyssa Garabedian ; Fenfei Leng ; Francisco Fernandez-Lima ; Jennifer S Brodbelt ; University of Texas at Austin, Austin, TX; Florida International University, Miami, FL TP 68 Investigating the Gas-Phase Conformation of Fibroblast Growth Factor upon Binding of Heparin/HS Using Traveling Wave Ion Mobility Spectrometry (TWIMS); Yuejie Zhao ; Jon Amster ; Arunima Singh ; Robert Woods ; Yongmei Xu ; Jian Liu ; Chengli Zong ; Geert-Jan Boons ; Fuming Zhang 4 ; Robert Linhardt 4 ; University of Georgia, Chemistry Department Athens, GA; University of Georgia, CCRC Athens, GA; University of North Carolina, Chapel Hill, NC; 4 Rensselaer Polytechnic University, Troy, NY TP 69 Screening Glycolipids Against Proteins in vitro using Picodiscs and Electrospray Ionization Mass Spectrometry; Jun Li ; Xuxin Fan ; Elena N Kitova ; John S Klassen ; University of Alberta, Edmonton, AB, Canada TP 60 Detecting Protein-Glycolipid Interactions using Glycomicelles and CaR-ESI-MS; Ling Han ; Elena N Kitova ; John S Klassen ; University of Alberta, Edmonton, Canada TP 6 Characterization of Heparin Interactions with its Client Proteins: Mapping Minimal Protein-Binding Domains within Glycosaminoglycan Chains using Top-down mass spectrometry; Yunlong Zhao ; Igor A Kaltashov ; University of Massachusetts Amherst, Amherst, MA TP 6 Screening Human Milk Oligosaccharides Against Proteins using Catch-and-Release Electrospray Ionization Mass Spectrometry; Yajie Chen ; Km Shams- Ud-Doha ; Elena N Kitova ; Lars Bode ; John S Klassen ; University of Alberta, Edmonton, Canada; University of California, San Diego La Jolla, CA 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

122 GENERAL TUESDAY INFORMATION POSTERS TP 6 TP 64 TP 65 TP 66 TP 67 TP 68 TP 69 TP 640 TP 64 TP 64 TP 64 TP 644 TP 645 Label Free, LC-MS Based Approaches to Quantitate Small Molecule-Receptor Binding; Xun Chen; Merck Research Labs, Kenilworth, NJ Label-free Size Exclusion Chromatography Mass Spectrometry for the Characterization of Protein Complex Composition and Stability; Paola Cavaliere ; Nadia Iqbal ; Noah E. Dephoure ; Weill Cornell Medical College, New York, NY Information-Rich Gas-Phase Analysis of Non-Covalent Protein Complexes and Released Subunits for Primary and Quaternary Structure Analysis; Deepali Rathore ; Forouzan Aboufazeli ; Eric D. Dodds ; University of Nebraska-Lincoln, Lincoln, NE Study of Noncovalent Interactions of Hydroxylated Polybrominated Diphenyl Ethers with Serum Albumins and Estrogen Receptors Using Ion Mobility Spectrometry-Mass Spectrometry; Qiang Ma ; Liang-Hong Guo ; Chinese Academy of Inspection and Quarantine, Beijing, CHINA; Chinese Academy of Sciences, Beijing, CHINA Investigating The Noncovalent Complex Formation of Proteins with Electrolytic Ligands in Gas Phase; Mehmet Atakay ; Haci Mehmet Kayili, ; Bekir Salih ; Hacettepe University, Department of Chemistry, Ankara, Turkey; Çankırı Karatekin University, Çankiri, Turkey Probing the Stability of Noncovalent Interactions Responsible for Covalently Linked Diubiquitin Ion Structure using nesi-twims-ms and CIU; Nicole Wagner ; David H Russell ; Texas A&M University, College Station, TX Identification of Grp78/BiP Protein Complexes using Affinity Mass Spectrometry; Dapeng Chen ; Yan Wang ; Eva R. Chin ; University of Maryland, College Park, MD Comparison of Affinity-Purification Mass Spectrometry Workflow for Charcaterisation of Protein Complexes; Lu Yu ; Mercedes Pardo ; Jyoti Choudhary ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire; Wellcome Trust Sanger Institute, Cambridge, United Kingdom Application of Affinity-purification Mass Spectrometry Based Predictive Mapping for Identification of RBM45 Protein Interactors in Amyotrophic Lateral Sclerosis; Krystine Garcia ; Yang Li ; Mahlon Collins, ; Jiyan An ; Rachel Geiser ; Tony Tegeler ; Kristine Tsantilas ; Robert Bowser, ; Patrick Pirrotte ; TGen, Phoenix, AZ; St. Joseph s Hospital and Medical Center, Phoenix, AZ; University of Pittsburgh School of Medicine, Pitts, PA Nanoprobe-based Affinity Mass Spectrometry for Identification of Binding Glycotopes and Protein- Protein Interaction of Galectin-8; Pin-Rui Su ; Chen Yi- Ju ; Lin Yu-Hsien ; Chen Yu-Ju ; Department of Chemistry, National Taiwan University, Taipei, Taiwan; Institute of Chemistry, Academia Sinica, Taipei, Taiwan; Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan Site-specific Characterization of Binding Interfaces in Gaseous HIV- RNA-protein Complexes; Eva-Maria Schneeberger ; Kathrin Breuker ; University of Innsbruck, Innsbruck, Austria Novel Blue-Native-PAGE and Targeted Mass Spectrometry Strategy Enable robust and Accurate Quantification of the Kinetics of Protein-Ligand Interactions in Plasma; Shichen Shen ; Xiaotao Duan ; Bo An ; Yang Qu ; Joseph Balthasar ; Jun Qu ; University at Buffalo, Buffalo, NY; Beijing Proteome Research Center, Beijing, China A New Carbene Probe for Efficient Protein Footprinting Allows Mapping of Binding Sites by Mass Spectrometry; Lucio Manzi ; Andrew Barrow ; Daniel Scott ; Robert Layfield ; Timothy Wright ; John Moses ; Neil Oldham ; University of Nottingham, Nottingham, UK TP 646 TP 647 TP 648 TP 649 TP 650 TP 65 TP 65 TP 65 TP 654 TP 655 Charting the Temporal Landscape of EGF-stimulated EGFR Proteome ; Yue Chen ; Sung Yun Jung ; Mei Leng ; Jong Min Choi ; Antrix Jain ; Anna Malovannaya ; Yi Wang ; Jun Qin ; Baylor College of Medicine, Houston, TX Development of a Novel Bioanalytical Platform for Anti- Drug Antibody using Immunocapture-LC/MS; Lin-Zhi Chen ; David Roos ; Elsy Philip ; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT; Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT Novel Regulators of Alternative NF-kB Pathway Identified through Chemical Proteomics; Bekim Bajrami ; Michelle Ols ; John Anderson ; Benbo Gao ; Brian Lucas ; Erik Hett ; Alan Buckler ; Peter Juhasz ; Ru Wei ; Biogen Inc., Cambridge, MA Proteomic Analysis Provides Clues about Normal FUS Function and Its Role in ALS; Jing Chen ; Marisa Kamelgarn ; Alexandra Arenas ; Jianjun Zhai ; Haining Zhu ; Jozsef Gal ; University of Kentucky, Lexington, KY Global Analyses of the Oligomerization, Composition, and Dynamics of Membrane-Associated Protein Complexes; Zach McBride ; Aryal Uma ; Chen Donglai ; Jun Xie ; Daniel Szymanski ; Purdue University, West Lafayette, IN Mass Spectrometry Cleavable Cross-linking Approach for Large-scale Identification of Protein-Protein Interactions; Jayanta Kishor Chakrabarty ; Apeksha Bhatt ; Saiful M Chowdhury ; University of Texas at Arlington, Arlington, TX Relative Abundance Comparative Analysis of ROSinduced Poly(ADP-ribose)-Associated Proteins by LC-MS/MS and Spectral Counting; Argel Islas-Robles, ; Frances M Munoz ; Serrine S Lau ; Terrence J Monks ; University of Arizona, Tucson, AZ; Wayne State University, Detroit, MI; Drexel University, Philadelphia, PA Fourier Transform Algorithm for Analysis of Mass Spectra for Heterogeneous Ions with Repeated Subunits; Sean P Cleary ; Jesse W Wilson ; Avery M Thompson ; James Prell ; University of Oregon, Eugene, OR Development of Mass Spectrometry Method for the Unbiased Detection of Cytomegalovirus Proteins in Human Brain Tumor Specimens; Dhiman Ghosh ; Brian P Milless ; Philip R Gafken ; Charles S Cobbs ; Swedish Neuroscience Institute, Seattle, Washington; Fred Hutchinson Cancer Research Center, Seattle, Washington; Fred Hutchinson Cancer Research Center, Seattle, WA Edgotypes and Quantitative Mass Spectrometry; James Bruce ; Juan Chavez ; Jimmy K Eng ; Arti Navare ; Devin Schweppe ; Xia Wu ; Xuefei Zhong ; University of Washington, Seattle, WA TP 656 Histidine, Arginine s Versatile Cousin; Amina S Woods ; Ludovic Muller ; Aurelie Roux ; Damon Barbacci ; Shelley N Jackson ; NIH/NIDA-IRP, Baltimore, MD; All Children s Hospital Johns Hopkins Medicine, Saint Petersburg, FL; Ionwerks Inc, Houston, TX TP 657 TP 658 TP 659 Examination of Aptamer-Protein Complex Structure by Mass Spectrometry; Guo-Ming Hung ; Pang-Hung Hsu ; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan Cross-linked PSMs in pepxml: a Common Format for Storing Cross-linked Search Results; Michael R. Hoopmann ; Luis Mendoza ; Eric W. Deutsch ; David Shteynberg ; Robert L Moritz ; Institute for Systems Biology, Seattle, WA The Analysis and Identification of STAT Interactions and Modifications in the Mitochondria of Cancer Cells; Daniel Garama ; Ching-Seng Ang ; Nick Williamson ; Daniel Gough ; Hudson Institute of Medical Research, Melbourne, Australia; Bio Institute, Melbourne, Australia PAGE 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

123 TUESDAY POSTERS Proteomics: Clinical Applications (Development toward Clinical Application) TP 660 Proteomic Profiling of Human Islets Collected from Pancreatic Tissue Sections using Laser Capture Microdissection; Lina Zhang ; Giacomo Lanzoni ; Matteo Battarra ; Luca Inverardi ; Qibin Zhang ;, Kannapolis, NC; Diabetes Research Institute, University of Miami, Miami, FL; Department of Chemistry & Biochemistry, University of North Carolina at Greensboro,, Greensboro, NC TP 66 Using Quantitative Proteomics to Profile Changes in Individual Immune Cell Types during an Immune Response; Allison Galassie ; Johannes Goll ; Parimal Samir ; Travis Jensen ; Kristen L Hoek 4 ; Leigh M Howard 5 ; Tara M Allos 4 ; Xinnan Niu 4 ; Sebastian Joyce 4, 6 ; Kathryn M Edwards 5 ; Andrew J Link 4 ; Department of Chemistry, Vanderbilt University, Nashville, TN; The EMMES Corporation, Rockville, MD; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN; 4 Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN; 5 Vanderbilt Vaccine Research Program; Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN; 6 Veterans Administration Tennessee Valley Healthcare System, Nashville, TN TP 66 LC-MRM Quantification of Protein Biomarkers in Human Saliva: In Saliva Veritas?; Jerome Vialaret ; Nora Nowak ; Audrey Gabelle ; Sylvain LEHMANN ; Christophe Hirtz ; LBPC, IRMB CHU Montpellier St. Eloi Montpellier, France; Centre Memoire Ressources Recherche Languedoc- Roussillon, CHU Montpellier, Montpellier, France TP 66 Elucidating Cellular Heterogeneity in Tumors: a Combination of Antibody-Based Cellular Pre- Fractionation and Ultrasensitive Proteomics; Evelyne Maes ; Nathalie Cools ; Inge Mertens, ; Dirk Valkenborg,, 4 ; Patrick Pauwels 5 ; Geert Baggerman, 6 ; VITO, Mol, Belgium; Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium; Center for Proteomics, Antwerp, Belgium; 4 Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium; 5 Pathology Department, University Hospital Antwerp (UZA), Antwerp, Belgium; 6 Center for Proteomics, Antwerp, Belgium TP 664 LC-MS Platform for Identifying Protein Targets of Small- Molecule Binding Relevant to Disease and Metabolism; Reid O Brien Johnson ; Brett Lomenick ; Jing Huang ; Joseph A Loo ; UCLA, Los Angeles, CA TP 665 Simple, Robust, Highly Productive Methodology for LC-MS/MS Quantitative Analysis of Laser Capture Microdissected Tissue from FFPE Biopsies Requiring 0,000 Cells; John P Shapiro ; Hannah Komar ; Phil Gafken ; Philip Hart ; Darwin Conwell ; Gregory Lesinski ; Ohio State University, Columbus, Ohio; Fred Hutchinson Cancer Research Center, Seattle, WA TP 666 Quantifying Signalling Pathway Activity using imaldi (immuno-maldi); Robert Popp ; Andrew G Chambers ; Adriana Aguilar-Mahecha ; Oliver Pötz ; Mark Basik ; Christoph H. Borchers 4, 5, 6 ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; Department of Oncology, McGill University, Montreal, QC, Canada; Natural and Medical Sciences Institute (NMI) at the University of Tübingen, Reutlingen, Germany; 4 University of Victoria - Genome BC Proteomics Centre, Victoria, BC; 5 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; 6 Segal Cancer Proteomics Center, Lady Davis Institute, McGill University, Montreal, QC, Canada TP 667 TP 668 TP 669 TP 670 TP 67 TP 67 TP 67 TP 674 Automation of an immuno-maldi assay for Quantifying Signalling Pathway Activity; Robert Popp ; Björn Fröhlich ; Andrew G Chambers ; Yassene Mohammed, ; Adriana Aguilar-Mahecha ; Oliver Pötz 4 ; Mark Basik ; Christoph H. Borchers, 5, 6 ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands; Department of Oncology, McGill University, Montreal, QC, Canada; 4 Natural and Medical Sciences Institute (NMI) at the University of Tübingen, Reutlingen, Germany; 5 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; 6 Segal Cancer Proteomics Center, Lady Davis Institute, McGill University, Montreal, QC, Canada Can volumetric Absorptive Micro Sampling in the Presence of a Stable-Isotope Labeled Protein Standard Control Pre-Analytical Variability in Proteomics?; Irene van den Broek ; Qin Fu ; Kevin Millis ; Timothy Eckersley ; William W Wood ; Michael P Kowalski ; Tara R Jones-Roe ; Stuart Kushon 4 ; Bobby Virasingh 4 ; Jennifer E Van Eyk ; Advanced Clinical Biosystems Research Institute, Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA; Cambridge Isotope Laboratories, Inc. Tewksbury, MA; Beckman Coulter Life Sciences, Indianapolis, IN; 4 Neoteryx, Torrance, CA Methodological Advances Applied to a Biomarker Study of Complex Samples from a Diseaded Clinical Cohort of Limited Sample Availability; Stephen Kostel ; Patricia Cho ; Hui Zhou ; John Froehlich ; Richard Lee ; Boston Children s Hospital, Harvard Medical School Boston, MA Combined Analysis of Nucleic Acids and Protein for Cancer Research; Jared Isaac ; Mazi Mohiuddin ; Thermo Fisher Scientific, Kalamazoo, MI; Thermo Fisher Scientific, San Jose, CA Human Plasma Proteome Analysis using Meter-Long Monolithic Silica Columns with Match-between-Runs; Yi Ting Wang ; Chia-Feng Tsai ; Kazuhiro Sonomura, ; Yasushi Ishihama ; Fumihiko Matsuda ; Center for Genomic Medicine, Graduate School of Medicine Kyoto University, Kyoto, Japan; Graduate School of Pharmaceutical Sciences Kyoto University, Kyoto, Japan; Life Science Research Center, Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan A Chromosome-Centric Protein-Protein Interaction Profiling of MS-Based Proteome Datasets Derived from Laser-Microdissected Cancerous Cells of Lung Cancer Subtypes; Kiyonaga Fujii ; Hiroyuki Kimura ; Hideki Marushima ; Rie Tagaya ; Hisashi Saji ; Noriaki Kurimoto ; Sayaka Mikami ; Yasuhiko Bando ; Noboru Nakayama, ; Harubumi Kato ; Toshihide Nishimura, ; Haruhiko Nakamura ; St. Marianna University School of Medicine, Meguro-ku, Tokyo; Biosys Technologies, Inc., Tokyo, Japan; Niizashiki Central General Hospital, Saitama, Japan High-resolution Quantitative Metaproteomics Pipe- Line: Documenting Effects of Dietary Changes; Boris Zybaylov ; Stephanie Byrum ; Galina Glazko ; Lisa Orr ; Dorothy Kieffer ; Sean Adams ; Samuel Mackintosh ; John Arthur ; Brian D. Piccolo ; Nosratola D. Vaziri ; Shuman Liu ; Wei L. Lau ; Mahyar Khazaeli ; Mary E. Moore 4 ; Roy J. Martin 5 ; University of Arkansas for Medical Sciences, Little Rock, AR; University of California, Davis, Davis, CA; Division of Nephrology, University of California, Irvine, Irvine, CA; 4 Dept. of Food Science and Technology, University of California, Davis, Davis, CA; 5 Obesity & Metabolism Research Unit, USDA, Davis, CA Investigation of Neutrophilic Proteins/Peptides in Periprosthetic Tissue by MALDI Imaging Mass Spectrometry; Rémi Longuespée ; Rita Casadonte ; Mark 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

124 GENERAL TUESDAY INFORMATION POSTERS TP 675 TP 676 TP 677 TP 678 TP 679 TP 680 TP 68 TP 68 TP 68 TP 684 TP 685 Kriegsmann ; Mike Otto, ; Sascha Gravius 4 ; Thomas Randau 4 ; Soeren-Oliver Deininger 5 ; Edwin De Pauw 6 ; Jörg Kriegsmann, ; Proteopath GmbH, Trier, Germany; University of Heidelberg, Heidelberg, Germany; Center for Histology Cytology and Molecular Diagnostics, Trier, Germany; 4 University Bonn, Bonn, Germany; 5 Bruker Daltonik, Bremen, Germany; 6 University of Liege, GIGA- Proteomics Liege, Belgium Generation of High Quality MALDI-TOF Serum Mass Spectra to Detect Hepatocellular Carcinoma in High- Risk Patients; Nicholas F Dupuis ; Maximillian Steers ; Alex A Nickel ; Gary P Pestano ; Biodesix, Inc., Boulder, Colorado [CO] Correlating Apolipoprotein Proteoform Profiles to Cardiovascular Disease Risk Factors: a Translational Top-Down Proteomics Approach to Pathophysiology; Henrique dos Santos Seckler ; Kyunggon Kim ; Luca Fornelli ; Paul M Thomas ; Philip Compton ; John T Wilkins ; Neil L Kelleher ; Northwestern University, Evanston, IL; Northwestern Feinberg School of Medicine, Chicago, IL Application of Tissue Surrogate for Variance Calibration in Mass Spectrometry Based Amyloidosis Diagnosis; Han-Yin Yang ; Andrew N Hoofnagle ; Michael J MacCoss ; University of Washington, Seattle, WA Quantitative Analysis of Protein Composition in Amyloid Plaques from FFPE Specimens using Parallel Reaction Monitoring (PRM); Maria Stella Ritorto ; Oana Madalina Mereuta ; Janine Pichardo ; Ahmet Dogan ; Memorial Sloan Kettering Cancer Center, New York, NY Analysis of Native Proteolytic BNP Variants: Simultaneous Separation of Multiple Samples using Capillary Electrophoresis-Mass Spectrometry with Multi-Segment Injection; Shenyan Zhang ; Koen Raedschelders ; Jennifer Van Eyk ; Barbra Streisand Women s Heart Center, Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA - California Implementation of sikalip to Identify the Substrates of CDKL5, a Kinase Linked to Severe Neurodevelopmental Disorders; Justine Arrington ; Juan Sebastian Paez Paez ; Weiguo Andy Tao ; Purdue University, West Lafayette, IN; National University of Colombia, Bogota, Colombia Dried Blood Spots as a Simple Sample Collection Tool for Personalized Medicine; Jeffrey J. Jones ; Ryan Benz ; Phong Cun ; William Smith ; John Blume ; Applied Proteomics Inc., San Diego, CA Proteomics: Infectious Diseases Characterization of the Host Proteome within Virion Particles of Sindbis Virus; Andrew Kilianski ; Amanda Piper ; Vancini Ricardo ; Raquel Hernandez ; Trevor Glaros ; ECBC, Apg, MD; North Carolina State University, Raleigh, North Carolina Mass Spectrometric Analysis of the Human Pathogen Cryptosporidium parvum; John Robert Haserick ; Deborah R Leon ; Yi Pu, ; John Crawford Samuelson, ; Catherine E Costello ; Boston University School of Medicine, Boston, MA; Boston University, Boston, MA; Boston University School of Dental Medicine, Boston, MA The Detection of a Clinically Relevant ß-lactamase, CTX-M-5, Using MALDI-TOF MS; Jonathan B. Thacker ; Brad S. Pierce ; Kevin A. Schug ; University of Texas at Arlington, Arlington, TX Pseudomonas aeruginosa Develops Ciprofloxacin Resistance from Low to High Level with Distinctive Proteome Changes; Jianhe Peng ; Jeffrey Hill ; Experimental Therapeutics Centre, A-STAR,Singapore, Singapore, Singapore; Experimental Therapeutics Centre, A-STAR, Singapore, Singapore TP 686 TP 687 TP 688 TP 689 TP 690 TP 69 TP 69 TP 69 TP 694 Proteomics Analysis of Chlamydia trachomatis: Virulence-Plasmid Mediated Protein Expression Changes; Christopher C R Grant ; Stuart McCorrister ; Michael Patton ; Harlan Caldwell ; Garrett R Westmacott ; Grant McClarty ; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada; Chlamydial Diseases Section, Laboratory of Clinical Infectious Diseases NIAID, NIH, Bethesda, MD - Maryland Mass Spectrometry Based Studies on Irreversible Inhibition of Recombinant Mycobacterium Tuberculosisshikimate Kinase by the Marine Sponge Metabolite Ilimaquinone; Angela Calderon ; Johayra Simithy ; Douglas Goodwin ; Mark T Hamann ; Auburn University, Auburn, AL; Auburn University, Auburn, Alabama; Medical University of South Carolina, Charleston, SC Determination of Hepatitis B Virus Infection by Means of Targeted Proteomics Strategy; Hsing-Fen Tsai ; He- Hsuan Hsiao ; NCHU, Department of Chemistry, Taichung, Taiwan A Key Retromer Trafficking Interactome of Toxoplasma Gondii Brought to Light by Comprehensive Proteomic Analyses; Benoît Westermann ; Lamba Omar Sangaré ; Agnes Hovasse ; Tchilabalo Dilezitoko Alayi ; Stan Tomavo ; Alain Van Dorsselaer ; Christine Schaeffer-Reiss ; IPHC, UdS CNRS UMR 778 Strasbourg, FRANCE; CNRS UMR 804, Lille, France Proteomic Deciphering of Cystic Echinococcosis using Laser Microdissection-based Microproteomics and MALDI Imaging; Rémi Longuespée ; Rita Casadonte ; Mark Kriegsmann ; Gabriel Mazzucchelli ; Edwin De Pauw 4 ; Michael Becker 5 ; Jörg Kriegsmann, 6 ; Proteopath GmbH, Trier, Germany; University of Heidelberg, Heidelberg, Germany; University of Liege, GIGA-Proteomics Liege, Belgium; 4 Université de Liège, Liège, Belgium; 5 Bruker Daltonik GmbH, Bremen, Germany; 6 Center for Histology Cytology and Molecular Diagnostics, Trier, Germany Plasma Proteomic Changes Induced by Salmonella Typhimurium Lipopolysaccharides in an Avian Model of Inflammation ; Balamurugan Packialakshmi ; Rohana Liyanage ; Jackson O Lay, Jr ; Sarbjeet K Makkar ; Narayan Rath ; University of Arkansas, Fayetteville, AR; PPPSRU, USDA-ARS Fayetteville, AR Top Down Proteomic Profiling of a Hypervirulent Clinical Isolate of Acinetobacter baumannii; Zack Li ; Kelly Fulton ; Rhonda Kuo Lee ; Howard H Xu ; Patricia Massel ; Susan Twine ; Wangxue Chen ; National Research Council Canada, Ottawa, Canada; California State University, Los Angeles, Los Angeles, CA - California Evolutionary Dynamics of Pseudomonas aeruginosa Revealed by Population Proteome Analysis; Xia Wu ; Katherine B Hisert ; Jayanthi Garudathri ; Benjamin J Staudinger ; Jimmy K Eng ; Colin Manoil ; Pradeep K Singh ; James E Bruce ; University of Washington, Seattle, WA A Plasmodium Vivax Trophozoite-schizont Stage Transition Proteome; D. C. Anderson ; Stacey A. Lapp ; John Barnwell ; Mary R. Galinski 4 ; SRI International, Harrisonburg, VA; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA; Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA; 4 Emory Vaccine Center, Yerkes National Primate Research Center, Emory University; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA PAGE 4 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

125 TUESDAY POSTERS TP 695 TP 696 TP 697 TP 698 TP 699 TP 700 TP 70 TP 70 TP 70 Bridging Virology with Proteomics to Define Mechanisms of Cellular Immune Signaling upon Herpesvirus Infection; Krystal K Lum ; Benjamin A Diner ; Joseph W Boerma ; Ileana M. Cristea ; Princeton University, Princeton, NJ Identifying Host Factors Associated with Replicating Viral DNA; Emigdio D Reyes, ; Katarzyna Julia Kulej, ; Daphne C Avgousti, ; Lisa Akhtar ; Daniel Bricker ; Neha Pancholi, ; Sarah A. Koniski ; Benjamin A Garcia 4 ; Matthew D Weitzman, ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Division of Cancer Pathobiology, The Children s Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA; 4 Epigenetics program, Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Protein-protein Interaction Network of Toll-like Receptor 4 in Macrophages with Exposure to their Agonists and External Factors; Abu Hena M Kamal ; Jayanta Kishor Chakrabarty ; Saiful M Chowdhury ; University of Texas at Arlington, Arlington, TX Engineering Novel Trypsin Cleavage Sites Improves Proteome Detection and PTM Recovery; Cristal Reyna ; Patricia A Champion ; Matthew M Champion ; University of Notre Dame, South Bend, Indiana; University of Notre Dame, Notre Dame, Indiana Understanding Virus Mechanisms by Means of Native Mass Spectrometry; Boris Krichel ; Sven Falke ; Johannes Heidemann ; Julia Lockhauserbäumer ; Rolf Hilgenfeld ; Mathhew Dunne 4 ; Rob Meijers 5 ; Lars Redecke ; Charlotte Utrecht, 6 ; Heinrich Pette Institute - Leibniz Institute for Experimental Virology, Hamburg, Germany; University of Hamburg, Hamburg, Germany; University of Lübeck, Lübeck, Germany; 4 ETH Zürich, Zürich, Switzerland; 5 EMBL Hamburg c/o DESY, Hamburg, Germany; 6 European XFEL, Hamburg, Hamburg Cracking the Code on N-Terminal Protein Acetylation in Mycobacterium tuberculosis; Cristal Reyna ; Patricia Champion ; Matthew Champion, ; University of Notre Dame, Notre Dame, IN; The Center For Rare And Neglected Diseases, Notre Dame, IN Proteomic Analysis of the Secretome of Dengue Virus-infected Vero Cells: Characterization of the Overexpressed Viral Non-structural Protein (NS); Chen-Ching Wu ; Chun-Hao Huang ; Shyh- Horng Chiou ; Kaohsiung Medical University, Kaohsiung City, Taiwan; Quantitative Proteomics Center and Graduate Institute of Medicine, Kaohsiung, TAIWAN (R.O.C.) itraq Proteomic and Protein Microarray Analysis of Potential Biomarkers OipA, BabA, and SabA in Helicobacter Pylori-related Gastric Cancer; Yu-Lin Su ; Jyh-Chin Yang ; Lu-Ping Chow ; Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan (R.O.C.); Department of Internal Medicine, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan (R.O.C.) Proteomics: Quantitative (Application Biological Research) Environmental Stress Induced Proteins Changes in Green Algae by Quantitative Proteomics; Yan Gao ; Teck Kwang Lim ; Qingsong Lin ; SAM LI ; Department of Chemistry, National University of Singapore, Singapore, Singapore; Department of Biological Sciences, National University of Singapore, Singapore, Singapore TP 704 TP 705 TP 706 TP 707 TP 708 Proteins Associated with Olfactory Receptor Nuclear Foci; Martin Escamilla Del Arenal ; Fiona Clowney ; Shujuan Tao ; David Chen ; Lewis M. Brown ; Stavros Lomvardas ; Columbia University, New York, NY; Columbia University, New York, NY Quantitative Proteomic Approach Reveals Landscape of the Regulatory Elements for Lysine -Hydroxyisobutyrylation Pathway; He Huang ; Kyle Delaney ; Shankang Qi ; Okwang Kwon ; Yingming Zhao ; The University of Chicago, Chicago, IL Proteomics-based Comparison of Ionic and Nano Silver at Cytotoxic Concentrations; Suresh Narayanasamy ; Samanthi I Wickramasekara ; Eric Sussman ; U.S. Food and Drug Administration, Silver Spring, MD; U.S. Food and Drug Administration, Silver Spring, MD Quantitative Proteomic Analysis of PPA-associated Proteins in BR Signaling Regulation Pathway; Chao Liu ; Shuo-Lei Bu ; Hao Chi ; Zhi-Yong Wang ; Si-Min He ; ICT, CAS, Beijing, China; Hebei Normal University, ShiJiaZhuang, China; Department of Plant Biology, Carnegie Institution for Science, Stanford, USA Insights from Redox Proteomics: Focus on S-glutathionylation Stoichiometry and Redox Status of Protein Cysteines; Jicheng Duan ; Matthew J Gaffrey ; Hannah J. Hatchell ; Rosalie Chu ; Richard D Smith ; Brian D Thrall ; Wei-jun Qian ; Pacific Northwest National Laboratory, Richland, Washington; Pacific Northwest National Laboratory, Richland, WA TP 709 An In-depth Proteome Foryeast Meiosis; Guo Yueshuai ; wen Fuping ; Hu Yang ; Wang Yuanting ; Wang Qian ; Yu Haiyan ; Tang Chaoming ; Sha Jiahao ; Guo Xuejiang ; Li Wei ; Nanjing Medical University, Nanjing, China; Institute of Zoology, Chinese Academy of Sciences, beijing, china TP 70 TP 7 TP 7 TP 7 TP 74 TP 75 Rootstock Influences Protein Profile at Different Stages of Berry Development in Grape, as Revealed by Whole Proteome Analysis using HRMS; Smita Maske ; Anuradha Upadhyay ; Satisha Jogaiah ; Akanksha Singh ; Dipankar Malakar ; Manoj Pillai ; Kaushik Banerjee ; ICAR-National Research Centre for Grapes, Pune, Maharashtra India; SCIEX, Gurgaon, Haryana; SCIEX, Gurgaon, Haryana India Proteome-wide Quantitative Profiling of Mis- Incorporation of Selenocysteine into Proteins by LC-MS Based Shotgun Proteomics; Chunlin Hao; The Hong Kong University of Science and Technology, Hong Kong SAR, HK A Mesenchymal Stem Cells differentiation study by using SILAC and Sequence-specific DNA Affinity Purification Approaches; Michele Puglia ; Inigo Barrio- Hernandez ; Blagoy Blagoev ; University of Southern Denmark, Odense, Denmark The Impact of Deyolking on Quantitative Proteomics in Zebrafish Embryos; Fatima Rahlouni ; Vladimir Shulaev ; Laszlo Prokai ; University of North Texas Health Science Center, Fort Worth, TX; University of North Texas, Denton, TX Investigation of Murine Neural Progenitor Cell to NG Cell Differentiation by TMT based Quantitative Proteomics; Carmen Schoor ; Alireza Dehghani ; Volkmar Gieselmann ; Dominic Winter ; University of Bonn, Bonn, Germany Proteomics- and Physiology-based Studies in Deciphering Epithelial Crosstalk Mechanism(s) Using Rhodnius prolixus as Experimental Model; Noman Hassan ; George Katselis ; Juan Ianowski ; University of Saskatchewan, Saskatoon, SK; University of Saskatchewan, Saskatoon, Canada 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

126 GENERAL TUESDAY INFORMATION POSTERS TP 76 TP 77 TP 78 TP 79 TP 70 TP 7 TP 7 TP 7 TP 74 TP 75 TP 76 TP 77 Age Dependent Protein Expression in Drosophila Models of Neurodegeneration; Chris Brown ; Jonathan C Trinidad ; David E Clemmer ; Indiana University Dept. Chemistry, Bloomington, IN Quantitative Proteome Profiling of Marinobacter sp. CP enriched from Microbial Fuel Cell Biocathode MCL; W. Judson Hervey, IV ; Zheng Wang ; Brian J. Eddie ; Anthony P. Malanoski ; Baochuan Lin ; Sarah M. Strycharz- Glaven ; Naval Research Laboratory, Center for Bio/ Molecular Science & Engineering, Washington, DC Novel Top-down Quantitative LC/MS Strategy Reveals New Insights into Molecular Heterogeneity In Skeletal Muscle; Ziqing Lin ; Liming Wei, ; Yutong Jin ; Wenxuan Cai ; Zachery Gregorich ; Gary M Diffee ; Ying Ge ; University of Wisconsin-Madison, Madison, WI; Fudan University, Shanghai, China Combined Discovery- and Targeted-based Proteomic Analysis of Tumor-Associated Antigen Peptides Derived from MAGE Proteins; Darshit Shah ; Xunbao Duan ; MacDonald Douglas ; Robert Salzler ; Regeneron Pharmaceuticals Inc., Tarrytown, NY; Regeneron Pharmaceuticals, Tarrytown, NY Fast MS/MS Data Acquisition without Dynamic Exclusion Enables Precise and Accurate Quantification of Proteome; Yichu Shan;, dalian, liaoning A Comparison of Isobaric Labeling with MS-XIC Quantitation using a Two-Proteome Model; David Mccaskill ; Trent Oman ; Tao Xu ; Jeffrey R Gilbert ; Dow AgroSciences, Indianapolis, IN Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis; Taylur Ma ; Steffan Vartanian ; James Lee ; Peter M Haverty ; Donald S Kirkpatrick ; Kebing Yu ; David Stokoe ; Genentech, Inc., South San Francisco, CA; Genentech Inc, South San Francisco, CA Proteomics Profiling of Parental and mab-producing CHO-derived Cell Lines to Facilitate Optimization of mab Production; Yee Jiun Kok ; Ally Lau ; Daniel Ng ; Lu Zheng ; Yuansheng Yang ; Xuezhi Bi ; Bioprocessing Technology Institute, Singapore Quantitative Analysis of Chromatin Proteome Remodeling Mediated by SWI/SNF Complexes; Zhiping Wu ; Eun-Ah Cho ; Haiyan Tan ; Haifeng Yang ; Junmin Peng ; ST. Jude, Memphis, TN; Thomas Jefferson University, Philadelphia, PA; St. Jude Children s Reseach Hospital, Memphis, TN Use of Variant Proteomics to Inform Genomic Searches for Novel Targets in Glioma; Ekaterina Mostovenko ; Melinda Rezeli ; Akos Vegvari ; Gyorgy Marko-Varga ; Yanhong Liu ; E. Susan Amirian ; Melissa L Bondy ; Carol L Nilsson ; UTMB Galveston, Galveston, TX; Lund University, Lund, Sweden; Dan L. Duncan Cancer Center, Houston, TX Determining Isotope Enrichment in Heavy Water Labeling; Jayant Avva ; Kwangwon Lee ; Takhar Kasumov ; Rovshan Sadygov ; University of Texas Medical Branch at Galveston, Galveston, TX; Northeast Ohio Medical University, Rootstown, OH; Northeast Ohio Medical University, Rootstown, OH Quantitative MS Investigation of the Effect of Amyloid- Beta on the Proteome Of Neuronal Cells; Maria I Indeykina,, ; Evgeny P Barykin 4 ; Alexey S Kononikhin,,5 ; Vladimir Mitkevich 4 ; Igor A Popov, ; Sergey Kozin 4 ; Alexander A Makarov 4 ; Eugene Nikolaev ; Emanuel Institute of Biochemical Physics, Moscow, Russia; Institute for Energy Problems of Chemical Physics, Moscow, Russia; Moscow Institute of Physics and Technology, Dolgoprudny, Russian Federation; 4 Engelhardt Institute of Molecular Biology, Moscow, Russia; 5 Research Center for Obstetrics and Gynecology, Moscow, Russia Small Molecules: Quantitative Analysis (Animal, Plant/Insect, and Methodology) TP 78 Quantitative Measurement of Carbidopa and Levodopa in Rat Plasma via HPLC with Tandem Mass Spectrometry; Jingduan Chi ; Yonghua Ling ; Mofikoya Melissa ; Fumin Li ; PPD, Middleton, WI TP 79 A Sensitive LC-MS-MS Method for Quantitation of Buprenorphine in Rat Brain Cerebrospinal Fluid; Fengying Zhu ; Perry (Peixin) Cao ; Ryan Turncliff ; Alkermes, Inc, Waltham, MA TP 70 Challenges and Solutions in the Bioanalysis of Sulprostone, a Prostaglandin E Analogue, in Rat and Monkey Plasma using LC-MS/MS; Yifan Shi ; Shefali Patel ; Naidong Weng ; Janssen Research and Development, Spring House, PA TP 7 A Novel Determination for Menthol in Rat Plasma using Salting-Out LLE and Derivatization Coupled with LC-MS/MS Detection; Mingluan Chen ; Milton Furtado ; Anahita Keyhani ; Algorithme Pharma Inc., Laval, Canada TP 7 Ultra Sensitive Method for Pre-clinical Quantification of Methacholine in Biological Matrices using SPE- HILIC Tandem Mass Spectrometry; Anders Lundqvist; TP 7 TP 74 TP 75 TP 76 TP 77 TP 78 TP 79 TP 740 TP 74 AstraZeneca Gothenburg, Gothenburg, Sweden Development and Validation of a Method to Quantitate Bisphenol AF in Rodent Plasma and Amniotic Fluid by LC/MS/MS; Bradley Collins ; Felicia Hubbard ; Kristin L. Aillon ; Joseph W. Algaier ; Suramya Waidyanatha ; National Institute of Environmental Health Sciences, Research Triangle Park, NC; MRIGlobal, Kansas CIty, MO Simultaneous Determination of Benzocaine, N-acetyl Benzocaine, and Tetracaine in Rabbit Plasma using High Performance Liquid Chromatography-Mass Spectrometry; Wuyi (Charlie) Zha ; Runlan Huo ; Mohamed Osman ; Xinping Fang ; Xin Zhang ; XenoBiotic Laboratories, Inc. WuXi AppTec Inc Plainsboro, NJ; WuXi AppTec Co., Shanghai, China Validation of a Method for Quantification of DMSO in Equine Urine using Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry; Matilda Salomonsson, ; Lena Ekman ; Mikael Hedeland ; Ulf Bondesson, ; The National Veterinary Institue (SVA), Uppsala, -; Uppsala University, Uppsala, Sweden; The National Veterinary Institute (SVA), Uppsala, Sweden A Robust LC/MS/MS Method for Quantitation of -morpholinoethanesulfonic acid (MES) in Dog and Rabbit Plasma; Todd Baughman; Covance, Durham, NC Analysis of Mycotoxins in Coix Seed using a Prototype Tandem Quadrupole Mass Spectrometer; Kerri Smith ; Kelly B Doering ; Mark Wrona ; Giorgis Isaac ; Jimmy Yuk ; Sukhdev Bangar ; Waters Corporation, Milford, MA; Waters Corporation, Beverly, MA Quantification of Biogenic Amines from Single Drosophila Cells by Direct MALDI-TOF MS; Max Diesner ; Susanne Neupert ; Biocenter Cologne, University of Cologne Cologne, Germany CBD/THC Quantitative Analysis with Direct Analysis in Real Time-Mass Spectrometry (DART-MS); Bohui Lv ; William Hoffmann ; Glen P Jackson ; West Virginia University, Morgantown, WV; Oak Ridge National Laboratory, CNMS Oak Ridge, TN A Combined MRM and SIM Method for Direct Quantitative Determination of Amino Acids in Various Samples on LC/MS/MS; Zhe Sun ; Jie Xing ; Pei Yee Khoo ; Zhaoqi Zhan ; Customer Support Centre, Shimadzu (Asia Pacific) Pte Ltd, Singapore; School of Physical & Mathematical Sciences, Nanyang Technological University Singapore, *Intern student Mass Spectrometry-Guided Refinement of Chemical Energy Buffers; Ting-Ru Chen ; Pawel Lukasz Urban ; PAGE 6 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

127 TUESDAY POSTERS TP 74 TP 74 TP 744 TP 745 TP 746 TP 747 TP 748 TP 749 TP 750 TP 75 TP 75 TP 75 TP 754 National Chiao Tung University, Hsinchu, Taiwan; Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan (R.O.C.) Obtain sub-ng/ml Levels for Steroids using a Simple, One-step Derivatization and a Novel, High Efficiency EI Source; Tim Conjelko ; Stephan Baumann ; Matthew Curtis ; Agilent Technologies, Santa Clara, CA Novel SPE Extraction Method for Sensitive and High Throughput Quantitative Analysis of Phosphorothioate Oligonucleotides in Human Plasma Using LC-MS/MS; Yuhuan Ji ; Qian Liu ; Qian Li ; Ji Chengjie ; Laixin Wang ; NovaBioAssays, LLC, Woburn, MA; NovaBioAssays, LLC, Worburn, MA Quantitation of Four Chiral Drug Compounds Simultaneously Using Normal Phase LC-MS/MS Equipped With an APPI Ion Source; Min Huang ; Zhongping (John) Lin ; Frontage Laboratories, Exton, PA The Use of Perchloric Acid as a Problem Solving Precipitating Agent to Overcome Method Development Issues; Pierre-Yves Caron ; Nicolas Jean ; Nadine Lafontaine ; Louis-Charles Boisvert ; Sylvain Lachance ; Nadine Boudreau ; Clark Williard ; inventiv Health, Québec, Canada A Novel Approach for Reducing the Isotopic Distribution Impact during Quantitation of Analyte by LCMSMS using Quadratic Regression Fit; Nathalie Pelletier ; Genevieve Emond ; Sylvain Lachance ; Nadine Boudreau ; Clark Williard ; inventiv Health, Québec, Canada Monitoring and Quantitating Genotoxic Impurities using Mass Detection and UV Sensitive Analysis Aryl Sulfonic Acid Esters; Mark Wrona ; Janet Hammond ; Jayne Kirk ; Sean Mccarthy ; Hillary Hewittson ; Margaret Maziarz ; Waters Corporation, Milford, MA; Waters Corporation, Wilmslow, UK Development of a Low Volume Quantitative Plasma Analysis Method Using a Flexible Capillary Microsampling Technique; Larry Mallis ; Wei Zhang ; Li Yuan ; Zhongping (John) Lin ; Frontage Laboratories, Exton, PA An Investigation on the Impact on Drug Stability in Biological Matrix when Stored in Multiple Tubes; Nader Youssef ; John Chapdelaine ; Weixing Sun ; Asvinkumar Patel ; Zhao Heng Ge ; Adrien Musuku ; Pharmascience, Montreal, Canada Simultaneously Determination of the Enantiomers of Ketorolac in Human Plasma by Atmospheric Pressure Chemical Ionization LC/MS/MS; Vince Windisch ; Feng Liang ; Allan Xu ; Keystone Bioanalytical Inc, North Wales, PA Trace Analysis of Potentially Mutagenic Impurities in Pharmaceutical Substances by Electron Ionization LC/MS (EI-LC/MS) with Supersonic Molecular Beams; Christine Fisher ; Ryan Cohen ; Renee Dermenjian ; Merck & Co., Rahway, NJ Expanding Horizons in Real Time Analysis: Dual Polarity SIFT-MS; Murray J Mcewan, ; David Hera ; Harry Gower ; Vaughan S Langford ; Thomas I McKellar ; Daniel B Milligan ; University of Canterbury, Christchurch, Canterbury; Syft Technologies Ltd, Christchurch, New Zealand Development of LC/MS/MS Method for Screening and Quantitation of 49 Synthetic Dyes in Textiles under Restricted Substance List (RSL); Yin Ling Chew ; Jie Xing ; Guan Seng, Leonard Lim ; Zhaoqi Zhan ; Shimadzu (Asia Pacific) Pte Ltd, Singapore; School of Physical & Mathematical Science, Nanyang Technological University, Singapore Isolation, Characterization and Color Stability of natural blue pigments; Andrew G Newsome ; Luying Chen ; Cathy A Culver ; Richard B van Breemen ; University of Illinois at Chicago, Chicago, IL; Pepsi-Cola Company, Hawthorne, NY TP 755 TP 756 TP 757 TP 758 TP 759 TP 760 TP 76 TP 76 Selective Enrichment of Flavonoids Using Pegylated Graphene Oxide and MALDI-TOF MS; Jaesung Lee; Konkuk University, Seoul, South Korea Development of a Sensitive Supercritical Fluid Chromatography (SFC)-MS/MS Method for the Analysis of Potential Genotoxic Impurities of Ondansetron; Jennifer Simeone ; Paula Hong ; Waters Corporation, Milford, MA Development and Testing of a Gas Generator for Odour Transmission over Data Networks; Stamatios Giannoukos ; Jeremy Smith ; Alan Marshall ; Stephen Taylor ; University of Liverpool, Liverpool, Please Select; University of Liverpool, Liverpool, United Kingdom Novel Applications of Paired Ion Electrospray Ionization Mass Spectrometry (PIESI-MS) for Sensitive Analysis of Anionic Compounds; Hongyue Guo ; Daniel W Armstrong ; University of Texas at Arlington, Arlington, TX Parallel Reaction Monitoring and Selected Reaction Monitoring Exhibit Comparable Analytical Performance in Quantitative Analysis of Cannabinoid; Xiaolei Xie ; Thomas Carrell ; Marta Kozak ; Thermo Fisher Scientific, San Jose, CA A Simple Systematic Strategy for Rapid Development of High-throughput and Reliable LC-MS/MS Assays for Regulated Bioanalysis; Long Yuan; Bristol-Myers Squibb, Princeton, NJ Commutability of LCMSMS Assays:Calibration by Internal or External Standardization?; R. Brent Dixon; Physician s Choice Laboratory Services, Rock Hill, SC Evaluation of an Innovative High-Throughput Online Solid Phase Extraction Tandem Mass Spectrometry System for Bioequivalence Studies; Jinhui Zhang ; Patrick J. Faustino ; FDA, Silver Spring, MD Top Down Protein Analysis (Methodology) TP 76 The National Resource for Translational and Developmental Proteomics offers novel opportunities for training and accelerated research in top-down proteomics; Neil L Kelleher ; Caroline J DeHart ; Ryan T Fellers ; Richard D LeDuc ; Paul M Thomas ; Northwestern University, Evanston, IL TP 764 Application of Spectral Counting for Top-down Proteomics Comparisons; Lucia Geis-Asteggiante ; Nathan Edwards ; Suzanne Ostrand-Rosenberg ; Catherine Fenselau ; University of Maryland, College Park, MD; Georgetown University Medical Center, Washington, DC; University of Maryland, Baltimore County Baltimore, MD TP 765 Increased Fragmentation Efficiency in Middle-down Protein Analysis using Different Collision Gases in a Modified Q-TOF Mass Spectrometer; Christian Klein ; Alex Mordehai ; Mark Werlich ; William E Barry ; Agilent Technologies, Santa Clara, CA TP 766 Protein Supercharging for Enhanced Top-Down Analysis with HCD MS/MS; Natalia Gasilova ; Kristina Srzentic ; Yury Tsybin ; Hubert H Girault 4 ; EPFL, Sion, Switzreland; EPFL, Lausanne, Switzerland; Spectroswiss Sàrl, Lausanne, Switzerland; 4 EPFL, Sion, Switzerland TP 767 Difference Mass Spectra for De novo Identification of N- and C-terminal Sequences of Intact Proteins; Harsha Gunawardena ; Dhanshri Bagal ; Daryl Bulloch ; Ping Cao ; David Chow ; Eddie Kast ; Matthew Rardin ; Nik Sharkov ; Peter Grandsard ; Amgen, Inc. South San Francisco, CA; Amgen, Thousand Oaks, CA TP 768 Top-down Targeted Proteomics Reveals Novel Molecular Mechanism in Sarcopenia; Zachery Gregorich ; Ying Peng ; Wenxuan Cai ; Yutong Jin ; Liming Wei ; Albert Chen ; Susan McKiernan ; Judd Aiken 4 ; Richard Moss ; Gary Diffee ; Ying Ge ; UW Madison, Madison, 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

128 GENERAL TUESDAY INFORMATION POSTERS TP 769 TP 770 TP 77 TP 77 WI; University of Wisconsin Madison, Madison, WI; Fudan university, shanghai, China; 4 University of Alberta, Edmonton, Canada Optimisation of intact Protein Sequencing through Testing Thousands of EThCD/ETciD MS/MS Fragmentation Conditions; Pavel Shliaha ; Derek Bailey ; Vladimir Gorshkov ; Ole N. Jensen ; Department of Biochemistry and Molecular Biology, University of Southern Denmark Odense, Denmark; Thermo Fisher Scientific, San Jose, CA Development of Mass Spectrometry-based Methods for Quality Assessment of Recombinant Proteins; Rosa I Viner ; Nan Liu ; Seema Sharma ; Sergei I Snovida ; Krishna Vattern ; David M Horn ; Thermo Fisher Scientific, San Jose, CA; Life Technology, South San Francisco, CA; Thermo Fisher Scientific, Rockford, IL Higher-order Structure Determines the Native ETD Fragmentation Behavior of Proteins and Complexes; Frederik Lermyte ; Mateusz Krzysztof Łącki ; Albert Konijnenberg ; Dirk Valkenborg ; Anna Gambin ; Frank Sobott ; University of Antwerp, Antwerpen, Belgium; University of Warsaw, Warsaw, Poland; VITO, Mol, Belgium Native Top-down Mass Spectrometry of Tau Proteins; Piriya Wongkongkathep ; Michael Nshanian ; Michael Ehrmann ; Gal Bitan ; Joseph A Loo ; UCLA, Los Angeles, CA; University of Duisburg-Essen, Essen, Germany TP 77 TP 774 TP 775 Mapping p5 Proteoforms by Native and Denaturing Top-down Mass Spectrometry; Caroline J DeHart ; Luca Fornelli ; Owen Skinner ; Philip D Compton ; Paul M Thomas ; Galit Lahav ; Jeremy Gunawardena ; Neil L Kelleher ; Northwestern University, Evanston, IL; Harvard Medical School, Boston, MA High-throughput Top Down Proteomics of HeLa cell lysates using UVPD; Timothy Cleland ; Ryan Parker ; Jennifer S Brodbelt ; University of Texas Austin, Pflugerville, TX; University of Texas at Austin, Austin, TX Quantitative Top Down Proteomics in Translational Research: Markers for Rejection in Peripheral Blood Following Kidney Transplantation; Timothy Toby ; John Savaryn ; Bryan P Early ; Paul M Thomas ; Ryan T Fellers ; Luca Fornelli ; Joseph B Greer ; Richard D Leduc ; Ioanna Ntai ; Zheng J Zhang ; John Friedewald ; Daniel Salomon ; Michael M Abecassis ; Neil L Kelleher ; Philip D Compton ; Northwestern University, Evanston, IL; Northwestern Feinberg School of Medicine, Chicago, IL; Scripps Center for Organ and Cell Transplantation, La Jolla, CA PAGE 8 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

129 WEDNESDAY POSTERS Set up all Wednesday posters...7:0 8:00 am Odd-numbered posters present...0:0 am :00 pm Even-numbered posters present...:00 :0 pm Remove all Wednesday posters...7:0 8:00 pm Ambient Ionization: Fundamentals and Instrumentation (Probes, Paper Spray, DESI/ESI, Tissue/Tools) Antibodies & Antibody Drug Conjugates (Sequencing, Modifications & Hi Res) Biomarkers: Discovery (Part ) Biomarkers: Quantitative Analysis (Part ) Carbohydrates (Glycans) Disease Biomarkers Drug Discovery/DMPK/ADME (General) Energy: Biofuels and Algae Environmental Analysis: Water Quality Food Safety: Other Contaminants (Part ) Food omics MS Characterization of Food and Nutritional Supplements (Part ) Forensics (Part ) GCMS: Instrumentation and Applications (Instrumentation-New Developments) Glycoproteins (Tandem MS, Separations, and Automation/Software) H/D Exchange: Hardware, Software and Methodology H/D Exchange: Protein Structure/Function (Part ) ICP and Isotope Ratio MS: Elemental Imaging MS: Method Development (DESI/SIMS/Misc) Informatics: Algorithms and Statistical Advances Informatics: Workflow and Data Management Instrumentation: Mini/Portable/Fieldable MS Instrumentation: New Developments in Ionization and Sampling (Sampling) Ion Mobility: Fundamentals Ion Structure/Energetics LC-MS: Sample Preparation (Part ) Lipids: Profile Analysis Metabolomics: Clinical Applications Metabolomics: Untargeted Metabolite Profiling (Animal/Human/Other) Nanoscale and Microfluidic Separations and MS Plant omics Protein Therapeutics: Quantitative Analysis Proteomics: New Approaches (Global) Proteomics: Quantitative (Labeling/Tagging/MS/ Quantitation) Small Molecules: Quantitative Analysis (Part ) Ambient Ionization: Fundamentals and Instrumentation (Probes, Paper Spray, DESI/ESI, Tissue/Tools) WP 00 Development of a DIP-APPI-IM-qTOF-MS; Simeon Horst ; Oliver Schmitz ; Universität Duisburg Essen, Essen, Germany WP 00 Development of a DIP-ESI-MS for Drug Analysis; Claudia Lenzen ; Oliver Schmitz ; Universität Duisburg Essen, Essen, Germany WP 00 Monolith Dip-It: A Bifunctional Device for Increasing the Sensitivity of Direct Analysis in Real Time; Li Xianjiang ; Yu Bai ; Liu Huwei ; Peking University, Beijing, China WP 004 Inert - Atmospheric Solid Analysis Probe: A New Fast and Easy Way to Characterize Air Sensitive Compounds by Mass Spectrometry; Mathilde Farenc,, ; Carlos Afonso, ; Pierre Giusti, ; TOTAL Refining and Chemicals, TRTG Gonfreville l Orcher, France; Normandie Univ, CNRS UMR 604 COBRA Mont St Aignan, France; TOTAL RC - CNRS Joint Laboratory CMC :Complex Matrices Molecular Characterization,France, WP 005 Applications and Fundamentals of Swab Touch Spray Mass Spectrometry; Alan K. Jarmusch, ; Valentina Pirro, ; R. Graham Cooks, ; Purdue University- Department of Chemistry, West Lafayette, IN; Center for Analytical Instrumentation Development, West Lafayette, IN WP 006 Coupling Paper Microfluidics with Paper Spray Mass Spectrometry for Improved Versatility and Analytical Performance; Ian Murray ; Glenn Walker ; Michael Bereman ; North Carolina State University, Raleigh, NC WP 007 In situ Separation and Analysis of Lipids by Paper Spray Ionization Mass Spectrometry; Sangwon Cha ; Purum Kim ; Hankuk Univ. Foreign Studies, Yongin, South Korea WP 008 High-Throughput Copper-Catalysts Screening and Their Catalytic Activity Studies Using Paper Spray Mass Spectrometry; Yajun Zheng ; Xuan Wang ; Teng Wang ; Yang Haijun ; Zhiping Zhang ; Xi an Shiyou University, Xi an, China; Tsinghua University, Beijing, China WP 009 Molecular Ionization at Low Voltage from One- Dimensional Nanostructures; Rahul Narayanan; Indian Institute of Technology, Chennai, Tamilnadu, India, Chennai, Tamilnadu WP 00 Dehydrogenation of Tetrahydroquinolines in Corona Discharge Plasma under Ambient Conditions using Graphite-Coated Hydrophobic Paper Surface; Kathryn Davis ; Abraham Badu-Tawiah ; The Ohio State University, Columbus, OH WP 0 Mass Spectrum Real-Time Online Optimizing Paal- Knorr Spary Reaction Temperature; XingPing Zeng ; Peng Zhou ; Huanwen Chen ; East China Institute of Technology, Nanchang, China; East China University of Technology, Nanchang, Mainland WP 0 Direct and Rapid Detection of Drugs in Urine by Extractive Electrospray Ionization Mass Spectrometry; Peng Zhou ; Tenggao Zhu ; Yongzi Liu ; Huian Zhao ; Huanwen Chen ; East China Institute of Technology, Nanchang, China; Jiangxi of Forensic Science Institute, Nanchang, China; East China University of Technology, Nanchang, Mainland WP 0 Coaxial Extractive Electrospray Ionization Mass Spectrometry; Kenneth D Swanson ; Steven L Reeber ; Gary L Glish ; University of North Carolina, Chapel Hill, NC WP 04 Generating Radical Cations of Aromatic Hydrocarbons through Reactive ESI Using the Single-Probe; Rachel Vowcicefski ; Ning Pan ; Zhibo Yang ; University of Oklahoma, Norman, OK; University of Oklahoma, Dept. of Chem & Biochem Norman, OK WP 05 Pinpointing the Source of Droplet Reactivity in Contained-electrospray Ionization; Dmytro Kulyk ; Abraham Badu-Tawiah ; Ohio State University, Columbus, OH WP 06 Solvent Assisted Inlet Ionization of Airborne Nanoparticles; Andy Horan ; Murray V Johnston ; University of Delaware, Newark, Delaware WP 07 Ionization Efficiency Comparison of ESI, SAI, and vsai Using Compounds with Different Surface Activities; Madeline Fenner ; Charles N McEwen ; University of the Sciences, Philadelphia, PA; University of the Sciences in Philadelphia, Philadelphia, PA WP 08 Effects of Volatile Anions and Cations as Spray Solvent Additives on the DESI MS Analysis of Proteins; Andre Venter ; Elahe Honarvar ; Wisam Alisawi ; Western Michigan University, Kalamazoo, MI WP 09 Top down DESI-UVPD of Proteins and Lipopolysaccharides on Polyvinylidene Difluoride Membranes; Dustin Klein ; Clara Feider ; Livia S Eberlin ; Jennifer S Brodbelt ; University of Texas at Austin, Austin, TX 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9

130 GENERAL WEDNESDAY INFORMATION POSTERS WP 00 DART Mass Spectrometry and Emission Spectra of Various DART Gas Sources; William A. Harris ; Johnny K Ho ; Douglas B Henderson ; Northrop Grumman, Linthicum Heights, MD WP 0 Ambient MS Based Analytical Platform for Rapid Identification of Brain Cancer Tumor Tissues; Igor A Popov, ; Evgeny Zhvansky, ; Nikita Levin ; Vsevolod Shurkhay ; Denis Bormotov ; Maria Indeykina, 4 ; Alexey S Kononikhin, 4 ; Yury Kostyukevich, 4 ; Evgeny Kukaev, ; Alexander Potapov ; Eugene Nikolaev ; Moscow Institute of Physics and Technology, Moscow, Russia; Institute for Energy Problems of Chemical Physics, Moscow, Russia; Burdenko Neurosurgical Institute, Moscow, Russian Federation; 4 Emanuel Institute of Biochemical Physics, Moscow, Russia WP 0 Assessment of Atmospheric Pressure Surface Mass Spectrometries for Improved Characterization and Imaging of Medical Devices; Felicia M Green ; Adam Taylor ; Rory Steven ; Elzbieta Gurdak ; Josephine Bunch ; National Physical Laboratory, Teddington, Middlesex; National Physical Laboratory, Teddington, UK WP 0 Liquid Microjunction Sampling for the Analysis of Proteins from Thin Tissue Sections; Rian Griffiths ; Elizabeth C Randall ; Helen J Cooper ; The University of Birmingham, Birmingham, UK WP 04 Ambient Bio-Molecular Mass Spectrometric Imaging with Subcellular Spatial Resolution; Jae Young Kim ; Eunsoek Seo ; Hyunmin Kim ; Dong-Kwon Lim ; Dae Won Moon ; Department of New Biology, DGIST, Daegu, South Korea; Nano and Energy Research Division, DGIST, Daegu, South Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South Korea WP 05 Spot Size, Sensitivity, and Fit for Purpose: Comparative Analysis of Extractive Analysis Techniques; Mariam S Elnaggar; Prosolia, Inc., Indianapolis, IN WP 06 Point-of-Care Tissue Analysis with Specificity for C=C Bond Lipid Isomers; Ran Zou, ; Xiao Wang, ; Leelyn Chong, ; Yuan Su, ; Xiaoxiao Ma, ; Jessica Page, ; Riyi Shi, ; Yu Xia, 4 ; Zheng Ouyang, ; Purdue University, West Lafayette, IN; Biomedical Engineering, Purdue University West Lafayette, IN; School of Veterinary Medicine, Purdue University, West Lafayette, IN; 4 Chemistry Department, Purdue University West Lafayette, IN WP 07 Robotic Surface Analysis Mass Spectrometry (RoSA- MS) for Automated Ambient Sampling of Highly- Curved Three-Dimensional Surfaces; Martin R L Paine ; Rachel V Stryffler ; Anyin Li ; Jake Huckaby ; Alexander S Lambert ; Ruffin J White ; Henrik I Christensen ; Facundo M Fernández ; Georgia Institute of Technology, Atlanta, GA; The Coca Cola Company, Atlanta, GA; Energid, Boston, MA WP 08 Ambient Robotic Mass Spectrometry via Cross Platform Synchonization; Jason Wu; Georgia Tech, Atlanta, Georgia WP 09 Development of a Field-Free Ambient Pressure Desorption Thermal Ionization Probe; Josh Swider ; Dale Chatfield ; San Diego State University, San Diego, CA Antibodies & Antibody Drug Conjugates (Sequencing, Modifications & Hi Res) WP 00 Protease-Containing Membranes For Controlled Digestion of Antibody Cocktails and Enhancement of Monoclonal Antibody Sequencing; Yongle Pang ; Merlin Bruening ; Department of Chemistry, Michigan State University, East Lansing, MI WP 0 Validation of Originator Sequences by Antibody Domain Mass Determination and Top-Down Sequencing; Anja Resemann ; Wolfgang Jabs ; Anja Wiechmann ; Elsa Wagner ; Colas Olivier ; Waltraud Evers ; Eckhard Belau ; Lars Vorwerg ; Catherine Evans ; Alain Beck ; Detlev Suckau ; Bruker Daltonic GmbH, Bremen, Germany; Centre d Immunologie Pierre-Fabre, St. Julien-en- Genevois, France WP 0 Distinguishing Leucine and Isoleucine Residues in de novo Sequencing of mabs using Nano LC-MSn: A Potential to Replace Edman Degradation; Dhanashri Bagal ; Ping Cao ; Eddie Kast ; Amgen, South San Francisco, CA; Amgen, Inc. South San Francisco, CA WP 0 High Throughput Antibody de novo Sequencing and Its Utility in Biopharmaceutical Discovery.; Kadir Ilker Sen ; Darryl Davis ; Wilfred Tang ; Marshall Bern ; Chris Becker ; Janssen Research and Development, Spring House, PA; Protein Metrics Inc., San Carlos, CA WP 04 Automated Antibody Sequencing Software; Wilfred Tang ; Marshall Bern ; Chris Becker ; Kadir Ilker Sen ; Protein Metrics Inc., San Carlos, CA; Janssen Research and Development, Spring House, PA WP 05 Rapid Quantitation of IgG after Digestion at Elevated Temperature with a Novel Trypsin Reagent; Michael Rosenblatt ; Daniel S Spellman ; Sergei Saveliev ; Kevin P Bateman ; Marjeta Urh ; Promega Corp, Madison, WI; Merck & Co., Inc., West Point, PA WP 06 Comparison of Various LC/MS Methods for Label-free Relative Quantitation of Site-specific Glycosylation of a Monoclonal Antibody; Pilsoo Kang ; Jianmei Kochling ; Sanofi Genzyme, Framingham, MA WP 07 Minimizing Method-induced Modifications in the Complementarity Determining Regions (CDRs) of Antibodies to Ensure Optimal Understanding of Product Quality Attributes; Jennifer Ide ; Elaine Stephens ; Michelle A English ; Jason C Rouse ; Lisa A Marzilli ; Pfizer, Andover, MA; Pfizer, Inc. Andover, MA WP 08 A Method Comparison for Quantifying Trisulfides in Monoclonal Antibodies: Non-Reduced Peptide Mapping LC-MS vs. Hydrophilic Interaction Chromatography- Charged Aerosol Detection; Christopher Cornell; Genentech, South San Francisco, CA WP 09 Impact of Fc N-Glycan Sialylation on IgG Structure; Zhongqi Zhang, ; Bhavana Shah ; Jason Richardson ; Amgen, Inc., Thousand Oaks, CA WP 040 Evaluation of a Rapid Method for Deamidation Profiling of Monoclonal Antibodies Suitable for Early Molecular Selection in Drug Discovery; Heather DeGruttola ; Elaine Stephens ; Michelle English ; Keith A Johnson ; Anja Wiechmann ; Guillaume Tremintin ; Jason Wood 4 ; Wolfgang Jabs ; Lisa A Marzilli ; Jason Rouse ; Pfizer, Inc. Andover, MA; Bruker Daltonic GmbH, Bremen, Germany; Bruker Daltonics, Fremont, CA; 4 Bruker Daltonics, Inc., Billerica, MA WP 04 The Effect of Sialylation of IgG s N-Glycans on FcRn Binding; Jake Pawlowski ; Adriana Bajardi-Taccioli ; Damian Houde ; Marina Feschenko ; Igor A Kaltashov ; Tyler Carlage ; UMASS Amherst, Amherst, Massachusetts; Biogen Inc., Cambridge, MA; University of Massachusetts, Amherst, MA WP 04 Characterization of Relative N-Glycan Occupancy in Antibodies using Mass Spectrometry; Ekaterina G. Deyanova ; Yun Wang ; Richard Huang ; Guodong Chen ; Bristol-Myers Squibb, Princeton, NJ WP 04 Analysis of O-linked Glycan Released from Biopharmaceuticals by using a Chemical Reaction and ASDF-incorporated Curved Field Reflectron.; Shuuichi Nakaya ; Yuzo Yamazaki ; Shimadzu Corporation, Kyoto, Japan WP 044 Building a High Confidence, Quantitative O-glycopeptide Profile for IgA; Amol Prakash ; Shadab Ahmad ; Scott M Peterman ; Julian A Saba ; Chu-Wei Kuo 4 ; Kay-Hooi Khoo 4 ; Rosa I Viner ; Optys Tech Corporation, PAGE 0 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

131 WEDNESDAY POSTERS Brighton, MA; Thermo Scientific BRIMS, Cambridge, MA; Thermo Fisher Scientific, San Jose, CA; 4 Academia Sinica, Taipei, Taiwan WP 045 A Novel Approach to Disulfide Bond Reduction in Antibodies using Electrochemistry with Online Mass Spectrometry; Arielle Verdi ; Laurent Rieux ; Martin Eysburg ; Andrew Milinichik ; Xin Cheng ; Earl Albone ; Morphotek Inc., Exton, PA; Antec LLC, Boston, MA WP 046 A Novel Method for Rapid Quantitative Determination of Total Free Sulfhydryls of an Antibody Fragment; Weitao Jia ; Qian Cai ; Jennifer Zhang ; Genentech Inc, South San Francisco, CA WP 047 Middle-down Approach for Monitoring Monoclonal Antibody Variants and Deglycosylation; Shanhua Lin ; Zoltan Szabo ; Yury Agroskin ; Terry Zhang ; Jonathan L Josephs ; Xiaodong Liu ; Thermo Fisher Scientific, Sunnyvale, CA; Thermo Fisher Scientific, San Jose, CA WP 048 Synthesis of Glycopeptides to be Used as Internal Standards for MALDI-MS Analysis of Tryptic Digestion Products from Antibodies; Rini Roy ; Ronald Domalaon ; Frank Schweizer ; Helene Perreault ; University of Manitoba, Winnipeg, Canada; University of Manitoba, Winnipeg, MB WP 049 Detection and Characterization of Stress-induced Oxidation and Deamidation onvulnerablesites of Etanercept Products; Li-Juan Huang ; Shu-Hui Chen ; Chemistry Dept. NCKU, Tainan, Taiwan (R.O.C.) WP 050 Rapid Evaluation of Domain-specific PTMs in mabs and Drug Conjugations in ADCs via a New Middle-down Proteomics Tool; Charles Nwosu ; Bisola Asaolu ; John Piscitelli ; May Zhu ; Takeda Pharmaceuticals International Inc., Cambridge, MA; Takeda Pharmaceutical International Inc., Cambridge, MA WP 05 Antibody Characterization Enabled by Automated Affinity Purification, Deglycosylation, IdeS Digestion, and Reduction; Steve Murphy ; Zach Van Den Heuvel ; Maryann Shen ; Jing Chen ; Agilent Technologies, Inc., Madison, WI; Agilent Technologies, Santa Clara, CA WP 05 Method Development of a Novel PK assay for Antibodyconjugated Drug Measurement of ADCs using Peptidelinker-drug Analyte; Suk-Joon Hyung ; Neelima Koppada ; Surinder Kaur ; Ola M Saad ; Genentech Inc, South San Francisco, CA WP 05 Linker-Drug Site Influences Antibody-Conjugated Drug Pharmacokinetic Assay Development for Antibody-drug Conjugates (ADCs); M. Violet Lee ; Surinder Kaur ; Ola Saad ; Genentech, South San Francisco, CA; Genentech Inc, South San Francisco, CA WP 054 Fast Online Characterization of Cetuximab Fd- Glycoprofile by Direct Monitoring and Control of a Mammalian Cell Cultivation Using Ultrahigh-Resolution QTOF Analysis; Martin Hedström ; Constantin Issleib ; Fredrik Olsson ; Dag Erlandsson ; Anja Wiechmann ; Anja Resemann ; Catherine Evans 4 ; Guillaume Tremintin 5 ; Jason S. Wood 6 ; Detlev Suckau ; Wolfgang Jabs ; CapSenze HB, Lund, Sweden; Genovis AB, Lund, Sweden; Bruker Daltonic GmbH, Bremen, Germany; 4 Bruker UK Ltd, Coventry, UK; 5 Bruker, Fremont, CA; 6 Bruker Daltonic, Billerica, MA WP 055 Advancing Attribute Control of Antibodies Drug Conjugates (ADCs) using High Resolution Analytics; Liuxi Chen ; Henry Y Shion ; Barbara Sullivan ; Ying-Qing Yu ; Weibin Chen ; Waters Corp., Milford, MA; Waters Corporation, Beverly, MA; Waters Corporation, Milford, MA WP 056 Physicochemical Structural Characterization of Innovator and Biosimilar Eculizumab with High Resolution Mass Spectrometry Methods; Maksim Degterev ; Maksim Smolov ; Grigoriy Poroshin ; Rakhim Shukurov ; IBC Generium, Vol ginskiy, Vladimirskaya Oblast WP 057 Probing Monoclonal Antibody-Protein Interactions by Native Mass Spectrometry on a Quadrupole Orbitrap Mass Spectrometer; Hongxia (Jessica) Wang ; Haibo Qiu ; Jonathan L Josephs ; Eugen Damoc ; Ning Li ; Regeneron Pharmaceuticals, Tarrytown, NY; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Bremen, DE WP 058 Top-down Characterization of Monoclonal Antibody on an Orbitrap Fusion Lumos Tribrid Mass Spectrometer; Seema Sharma ; Stephane Houel ; Christopher Mullen ; Chad Weisbrod ; Romain Huguet ; John Syka ; David Horn ; Jonathan Josephs ; Jae Schwartz ; Vlad Zabrouskov ; Thermo Fisher Scientific, San Jose, CA WP 059 Complete Characterization of Biotherapeutic Proteins by Automated Data Processing on High Resolution Accurate Mass Spectrometry with SWATH Acquisition; Milla Neffling ; Yang Shi ; Dominic Gostick ; Doug Simmons ; SCIEX, Concord ON, Canada; SCIEX, Concord, ON WP 060 Full Characterization of Heterogeneous Antibody Samples under Denaturing and Native/Native-Like Conditions on a Hybrid Quadrupole-Orbitrap Mass Spectrometer; Kai Scheffler ; Eugen Damoc ; Aaron Bailey ; Stephane Houel ; Jonathan L Josephs ; Thermo Fisher Scientific, Dreieich, DE; Thermo Fisher Scientific, Bremen, DE; Thermo Fisher Scientific, San Jose, CA WP 06 High Resolution Mass Spectrometry of a Bispecific Antibody for the Treatment of Pertussis; Ellen K Wagner ; Andre Bui ; Tingting Wang ; Maria D Person ; Jennifer A Maynard ; University of Texas at Austin, Austin, TX Biomarkers: Discovery (Part ) WP 06 Serum Haptoglobin Glycosylation as a Potential Biomarker to Monitor Lung Cancer Development; Ruiqing Zhang ; Yujie Liu ; Dan Zhang ; Zhili Li ; Institute of Basic Medical Sciences, CAMS & PUMC, Bejing, CN; IBMS, CAMS&PUMC, Beijing WP 06 Urine Peptidome Study as a Promising Approach for Preeclamsia Diagnosis; Nataliia Starodubtseva, ; Alexey S Kononikhin, ; Anna Bugrova, ; Igor A Popov,, ; Victoria Shirokova, 4 ; Maria Indeykina, 4 ; Olga Vavina ; Kamila Muminova ; Yury Kostyukevich, 5 ; Vitaliy Chagovets ; Vadim Lagutin ; Evgeny Kukaev, ; Vladimir E Frankevich ; Zulfia Khodzhaeva ; Gennady Sukhikh ; Eugene Nikolaev 4 ; Research Center for Obstetrics and Gynecology, Moscow, Russia; Moscow Institute of Physics and Technology, Moscow, Russia; Emanuel Institute of Biochemical Physics, Moscow, Russia; 4 Institute for Energy Problems of Chemical Physics, Moscow, Russia; 5 Skolkovo Institute of Technology, Moscow, Russia WP 064 Identification of Serum Protein Biomarkers Associated with Early Heterotopic Ossification Formation following Traumatic Injury; Michael E. Hoover ; Claire Llamas ; Elizabeth C. Martin ; Elaine Boos ; Peter C. Krause ; Andrew G. King ; Harry Molligan ; Olivia C. Lee ; Vinod Dasa ; Thomas A. Davis 4 ; Ammar Qureshi 4 ; Benjamin Levi 5 ; Jonathan A. Forsberg 4 ; Jeffrey M. Gimble ; Michael A. Freitas ; Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH; Center for Stem Cell Research and Regenerative Medicine, Tulane University, New Orleans, LA; Department of Orthopedics, LSU Health Sciences Center, New Orleans, LA; 4 Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD; 5 Department of Surgery, University of Michigan, Ann Arbor, MI WP 065 Identification of Nephropathy Prognostic Markers in Urine from Children Affected by type- Diabetes; Magagnotti Cinzia ; Gianpaolo Zerbini ; Isabella Fermo ; Rose Mary Carletti, ; Riccardo Bonfanti ; Fabiana Vallone ; 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

132 GENERAL WEDNESDAY INFORMATION POSTERS Arianna Restivo 4 ; Giambattista Capasso 4 ; Annapaola Andolfo ; OSR, Milan, Italy; IEO, Milan, Italy; IFOM, Milan, Italy; 4 Second University of Naples, Naples, Italy WP 066 Deep Profiling of Extracellular Vesicles in µl-scale Plasma Samples Using Miniaturized Isolation Combined with Advanced Separation and MS Data Acquisition; Simion Kreimer ; Arseniy M Belov ; Rosa I Viner ; Marcia Santos ; Barry L Karger ; Alexander R. Ivanov ; Northeastern University, Boston, MA; Thermo Fisher Scientific, San Jose, CA; SCIEX, Redwood City, CA WP 067 Selection of Protein Biomarkers in Dehaloccoides Mccartyistrains Enables an MRM-MS Approach for Monitoring Dechlorination Activities in Environmental Samples; Manuel Villalobos, ; Karuna Chourey ; Frank Loeffler ; Robert Hettich, ; University of Tennessee- Knoxville, Knoxville, TN; Oak Ridge National Laboratory, Oak Ridge, TN WP 068 Proteome Analysis of Plasma Extracellular Vesicles and the Impact of Sampling Conditions; Ole Østergaard ; Julia Tanas Tanassi ; Henrik Niels Helweg Heegaard ; Statens Serum Institut, Copenhagen, Europe; Statens Serum Institut, Copenhagen, Denmark WP 069 Methodological Development for Exosome Enrichment in Serum; Yan Ren ; Jin Zi ; Liang Lin ; Siqi Liu ; BGI- Shenzhen, Shenzhen, China WP 070 Serum N-glycome Analysis of Colorectal Cancer Patients Reveals Association with Survival; Stefan W de Vroome ; Stephanie Holst ; Mar DM Rodriguez Girondo ; Bart JA Mertens ; Yuri EM van der Burgt ; Wilma E Mesker ; Manfred Wuhrer ; Rob AEM Tollenaar ; Leiden University Medical Center (LUMC), Leiden, The Netherlands WP 07 Identification of Urinary Protein Biomarkers for Diagnosis of Hepatocellular Carcinoma by an Oncoproteogenomics Approach; Thomas S.-H. Chiou, ; Chun-Hao Huang, ; Shu-Wen Chi ; Chao-Jen Kuo ; King-Teh Lee ; Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan; Weill Graduate School of Medicine, Cornell University, Ithaca, NY WP 07 The Ascites N-glycome of Epithelial Ovarian Cancer Patients; Karina Biskup, ; Elena I Braicu ; Jalid Sehouli ; Rudolf Tauber ; Véronique Blanchard ; Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité Medical University, Berlin, Germany; Department of Biology, Chemistry and Pharmacy, Freie University of Berlin, Berlin, Germany; Department of Gynecology, Berlin, Germany WP 07 Blood Proteins with Isoelectric Point Close to 7.4 as Alzheimer Disease Biomarker; Mohammad Pirmoradian Najafabadi, ; Thorleif Lavold ; Dag Aarsland, 4 ; Roman A Zubarev ; Karolinska Institutet, Solna, Sweden; Biomotif AB, Stockholm, Sweden; Karolinska Institutet, Stockholm, Sweden; 4 King s College London, London, UK WP 074 Searching for CSF Biomarkers in PGRN Associated Frontotemporal Dementia; Diana Nijholt ; Lieke Meeter ; Christoph Stingl ; Lennard Dekker ; Jeroen van Rooij ; Shami Melhem ; Theo M. Luider ; John van Swieten ; Erasmus Medical Center, Rotterdam, The Netherlands WP 075 Expanding the CSF Endopeptidome by High-pH reversed-phase Fractionation and LC-MS/MS; Karl Hansson ; Elin Pernevik ; Silke Kern ; Kaj Blennow ; Henrik Zetterberg ; Johan Gobom ; Gothenburg University; Institute of Neuroscience and Physiology, Gothenburg, Sweden WP 076 Clinical CSF Proteomics and Endopeptidomics for Biomarker Identification in Neurodegenerative Diseases; Johan Gobom ; Karl Hansson ; Elin Pernevik ; Tobias Skillbäck ; Henrik Zetterberg ; Kaj Blennow ; University of Gothenburg, Institute of Neuroscience and Physiology, Gothenburg, Sweden WP 077 Identifying Prostate Cancer Biomarkers by Profiling Glycoproteins in Human Prostate Tissue; David Spiciarich ; Sophia L. Maund ; Sean Purcell ; Anthony T Iavarone ; Donna M. Peehl ; Carolyn R Bertozzi 4, 5 ; University of California, Berkeley, CA; Stanford University School of Medicine, Palo Alto CA, USA; UC Berkeley, Berkeley, California; 4 Stanford University, Stanford, CA; 5 Howard Hughes Medical Institute, Chevy Chase, MD WP 078 Mass Spectrometry-Based Proteomics of Human Breast Milk to Assess Breast Cancer Risk Using Different Protein Digestion procedures; Roshanak Aslebagh ; Kathleen F Arcaro ; Costel C. Darie ; Clarkson University, Potsdam, NY; University of Massachusetts Amherst, Amherst, MA WP 079 Mass Spectrometric Analysis of Salivary Proteins from Medical Residents Performing Advanced Clinical Simulations Resulting in Acute Stress; Rachel Marvin ; Muncharie Brooke Saepoo ; Paul Rega ; Viviane Kazan ; Kenneth Hensley ; David Giovannucci ; Dragan Isailovic ; University of Toledo, Toledo, OH WP 080 High Through-Put Quantitative Proteomics for the Discovery of Circulating Biomarkers in Cancer; Hong Wang ; Juan Chen ; Xiaoqian Liu ; Clemente Aguilar Bonavides ; Amin Momin ; Hiroyuki Katayama ; Sam Hanash ; MD Anderson Cancer Center, Houston, TX WP 08 Proteomic Approach towards Early Diagnosis of Ventilator-Associated Pneumonia (VAP) in Critically Ill Patients; Khyatiben Pathak ; Marissa Saltzman ; Emmanuel B Menashi ; Frederic Zenhausern 4 ; Patrick Pirrotte ; Center for Proteomics, The Translational Genomics Research Institute, Phoenix, AZ; Center for Proteomics, Translational Genomics Research Institute, Phoenix, AZ; Laboratory for Genomics and Personalized Medicine, Honor Health Research Institute, Scottsdale, AZ; 4 Center for Applied Nanobioscience and Medicine, University of Arizona, Phoenix, AZv WP 08 Intact Protein Profiling of Proteoforms Moves toward the Clinic: Intact Protein Classification of Patients with Acute Rheumatic Fever; Giuseppe Infusini ; Laura Dagley ; Willy-John Martin ; Liam O Connor ; Ian Wicks ; Andrew Webb ; Walter & Eliza Hall Institute, Parkville, VIC; Walter & Eliza Hall Institute, Parkville, Australia WP 08 A SWATH-MS Method to Monitoring Oxidative Stress and Progression to Cell Death: From Secretome to Blood Diagnosis; Sandra Anjo ; Vera Mendes ; Mário Grãos, ; Bruno Manadas ; Center for Neurosciences and Cell Biology, Coimbra, Portugal; Biocant - Biotechnology Innovation Center, Cantanhede, Portugal WP 084 Chronic Human African Trypanosomiasis Biomarker Discovery Using Quantitative Proteomics; Matthew Szucs ; Rushdy Ahmad ; Brett Eyford ; Terry Pearson ; Steven A Carr ; Broad Institute of MIT and Harvard, Cambridge, MA; University of Victoria, Victoria BC, Canada WP 085 Application of Adductomics for Investigating Biomarkers Associated with Ovarian Cancer; Daniel Ladror ; William Funk ; Northwestern University, Chicago, IL; Northwestern University, Evanston, IL WP 086 Serialized Nanoparticle-Mediated Enrichment and Profiling of the Saliva Proteome; Marissa Saltzman ; Kelsey Mitchell ; Kristine Tsantilas ; Khyati Pathak ; Christophe Legendre ; Victoria David ; Matthew Rosenow ; Shane Caswell ; Lance Liotta ; Emanuel Petricoin ; Patrick Pirrotte ; Translational Genomics Research Institute, Phoenix, AZ; Center for Applied Proteomics and Molecular Medicine, Manassas, VA; Sports Medicine Assessment Research and Testing (S.M.A.R.T.) Laboratory, Manassas, VA PAGE 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

133 WEDNESDAY POSTERS WP 087 Identification of Serum Biomarker Candidates for Fatty Liver Disease through Depletion of Common High- Molecular-Weight Proteins; Sachin Sridharan ; Sobanaa Jayakumar ; Keerthana Vinodh ; Adaikkalam Vellaichamy ; Anna University, Chennai, India WP 088 Analysis of Possible Biomarkers for Complex Regional Pain Syndrome and Osteoporosis using nlc-ms; Johan Jacksén ; Linus Svenberg ; Åsa Emmer ; KTH Royal Institute of Technology, Stockholm, Sweden Biomarkers: Quantitative Analysis (Part ) WP 089 Targeted Quantification of Mutant SPOP Proteins in Prostate Cancer; Hui Wang ; Christopher E. Barbieri ; Jintang He ; Yuqian Gao ; Chaochao Wu ; Athena A. Schepmoes ; Thomas L. Fillmore ; Tujin Shi ; Sung-Suk Chae ; Dennis Huang ; Juan Miguel Mosquera ; Wei-Jun Qian ; Richard D. Smith ; Sudhir Srivastava ; Jacob Kagan ; David Camp ; Karin D Rodland ; Mark A. Rubin ; Tao Liu ; Pacific Northwest National Laboratory, Richland, WA; Institute of Precision Medicine of Weill Cornell Medical College and New York Presbyterian Hospital, New York, NY; National Cancer Institute, Bethesda, MD WP 090 Quantitative Tau Isoform Differentiation; Paul Auger ; Stephen Schauer ; W. Rodney Mathews ; Lee Honigberg ; Kristin R Wildsmith ; Genentech, South San Francisco, CA; Genentech Inc, South San Francisco, CA WP 09 Developing LC-MS Assay for Pituitary Adenylate Cyclase-Activating Polypeptide; Ruina Li ; Yuzhong Deng ; Brian Dean ; Xiaorong Liang ; Genentech Inc, South San Francisco, CA WP 09 Proteomic and Biochemical Analyses of EAM Rat; Jong Bok Seo ; Soo Jeong Park ; Seung Min Choi ; Korea Basic Science Institute, Seoul, Republic of Korea; Korea Basic Science Institute, Seoul, Republic of Korea WP 09 Development of a Sensitive LC-MS/MS Method to Quantify Substance P Concentrations in Rat Cerebrospinal Fluid; Hanumanth Rao Pantangi ; Lakshmi Prasanna Rayapati ; Prathyusha Chunduru ; Saivishal Daripelli ; Ganesh Ayyanki ; Venkatesh Kamuju ; Ramakrishna Nirogi ; Suven Life Sciences Ltd, Hyderabad, Telangana WP 094 MRM-based Assay for Potential Protein Biomarker in Meningioma Patients; Shuvolina Mukherjee ; Ajit Datar ; Rashi Kochhar ; Sanjeeva Srivastava ; Vedita Anand Singh ; Nikita Gahoi ; Saicharan Ghantasala ; Aliasgar Moiyadi ; Epari Sridhar ; Indian Institute of Technology Bombay, Mumbai, INDIA; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, INDIA; Tata Memorial Center, Mumbai, INDIA WP 095 MRM Based Targeted Analysis of Serum Samples to Demonstrate Differentially Expressed Proteins in Severe Cases Of Falciparum Malaria; Vipin Kumar ; Shailesh Damale ; Ajit Datar ; Sanjeeva Srivastava ; Indian Institute of Technology Bombay, Mumbai, India; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, India WP 096 Development of MRM Assay for the Determination of Potential Biomarkers in Case of Severe Vivax Malaria; Sandip Patel ; Shailendra Rane ; Ajit Datar ; Swati Patankar ; Sanjeeva Srivastava ; Indian Institute of Technology Bombay, Mumbai, India; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, India WP 097 Quantitative Profiling of Hypoxia-responsive Cellular Pathways Associated with Metastasis in Osteosarcoma by Parallel Reaction Monitoring Assay; Zifeng Song ; Liping Yang ; Luisa Zini ; Caleb Emmons ; Siva Kolluri ; Millan Shay ; Milan Milovancev ; Claudia S Maier ; Oregon State University, Corvallis, OR; Proteome Software, Portland, OR WP 098 Analysis of Glycosylation of Serum CD90 in Pancreatic Cancer by Mass Spectrometry; Jun Cao, ; Jianhui Zhu ; Rui Yang ; Zhijing Tan ; Mingrui An ; David M. Lubman ; University of Michigan Medical Center, Ann Arbor, MI; Hangzhou Normal University, Hangzhou, China WP 099 Quantification of the Unique eef His75-Diphthamide post-translational Modification and Its Derivatives by Parallel Reaction Monitoring Mass Spectrometry; Axel Ducret ; Sabine Kux van Geijtenbeek ; Sebastian Stahl ; Ana Rita da Silva Mateus Seidl ; Sven Michel ; Gerhard Niederfellner ; Ruediger Rueger ; Ulrich Brinkmann ; F. Hoffmann-La Roche Ltd, Basel, Switzerland; F. Hoffmann- La Roche Ltd, Penzberg, Germany WP 00 Analysis of Human Dried Blood Spots for Cotinine and trans- -Hydroxycotinine by Reversed Phase Ultra Performance Liquid Chromatography Tandem Mass Spectrometry; Alexandria L Anstett, ; Michael C Stagliano ; S. Alexandra Burt ; Matthew J Geiger ; Sara E Tomechko ; Michigan State University, East Lansing, MI; MI Department of Health & Human Services, Lansing, MI WP 0 Novel Proteomics-Based Pipeline for Identifying Predictive Biomarkers of Taxane-Induced Neuropathy; Emily Chen ; Katherine D. Crew, ; Meghna Trivedi ; Danielle Awad 4 ; Mathew Maurer ; Kevin Kalinsky, 4 ; Antonius Koller 5 ; Purvi Patel 5 ; Jenny Kim Kim 5 ; Dawn Hershman,, 4 ; Columbia University Medical Center, New York, NY; Department of Medicine, Columbia University Medical Center, New York, NY; Department of Epidemiology, Columbia University Medical Center, New York, NY; 4 Herbert Irving Comprehensive Cancer Center, New York, NY; 5 Herbert Irving Comprehensive Cancer Center, Proteomics Shared Resource, New York, NY WP 0 Quantification of Lysosomal Storage Disease Specific Urinary Oligosaccharides for Potential Treatment Monitoring; Rongrong Huang ; Allison Cason ; Laura Pollard ; Tim Wood ; Greenwood Genetic Center, Greenwood, SC WP 0 Evaluation of Stable Isotope Dimethyl Labeling and Spectra Counting for Protein Profiling in Mice with Nonalcoholic Steatohepatitis; Zhicheng Jin ; Takhar Kasumov ; Northeast Ohio Medical University, Rootstown, OH; Northeast Ohio Medical University, Rootstown, OH WP 04 Rapid Detection of a Low-Abundance Biomarker from Plasma Using Combined Capture and Digestion for Improved Sensitivity; John O Grady ; Kevin Meyer ; Derrick Poe ; Perfinity Biosciences, Inc West Lafayette, IN WP 05 Multiplexed Longitudinal Monitoring of Cancer Biomarkers in Dried Blood Spots using an Automated SISCAPA Workflow; Morteza Razavi ; Leigh Anderson ; Richard Yip ; Matthew E. Pope ; Terry W Pearson ; SISCAPA Assay Technologies, Washington, DC WP 06 Standardizing Targeted Mass Spectrometry Quantification of Dystrophin Toward Implementation in Clinical Trials; Kristy J Brown ; Meng Hsuan Han ; Mamta Giri ; Shivaprasad Bhuvanendran ; Jyoti Jaiswal ; Eric P Hoffman ; Yetrib Hathout ; Children s National Healthy System, Washington DC, DC; Children s National Medical Center, Washington, DC WP 07 Rapid QQQ Screening and Quantification of Proteins from Complex Biological Matrices using Retention Time Predictor without Expensive Protein Standards; Rohana Liyanage ; Balamurugan Packialakshmi ; Jeremy Post ; Narayan C. Rath 4 ; Jackson O. Lay, Jr ; University of Arkansas, Fayetteville, AR; University of Arkansas, Fayetteville, AR; Shimadzu Scientific Instruments, Columbia, MD - Maryland; 4 PPPSRU, USDA, Agricultural Research Service, Fayetteville, AR 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE

134 GENERAL WEDNESDAY INFORMATION POSTERS WP 08 Development of Peripheral Blood Mononuclear Cell (PBMC) Based Protein Biomarkers for Lung Cancer Diagnosis using DIA Mass Spectrometry; Shaohua Xu ; Chunlin Cai ; Feng Yao ; Qian Wu 4 ; Heng Zhao ; Wei Yan ; Shanghai Jiatong University, Shanghai, China; Shanghai Jiao Tong University, Shanghai, China; Shanghai Chest Hospital, Shanghai, China; 4 Shanghai Center for Bioinformation Technology, Shanghai, China WP 09 High Sensitivity and High Specificity LC-HRMS Method to Quantify the Corticosteroid Metabolome after Exposure to Inhaled Corticosteroids; Clementina A Mesaros ; Dominic Ciccimaro, ; Nathaniel W Snyder ; Ian A Blair, ; University of Pennsylvania, Philadelphia, PA; Penn SRP Center and CEET, Philadelphia, PA; AJ Drexel Autism Institute, Philadelphia, PA WP 0 Quantitative Evaluation towards the Glutathione S-Transferases in Human Plasma Using Affinity Coupling with LC-MS/MS; Feng Xian; Beijing Institute of Genomics, CAS, Beijing, Beijing WP Absolute Quantitation of Biomarkers Predictive of Recovery from Acute Kidney Injury after Liver Transplantation with nano-lc - Triple-Quad Mass Spectrometry; Jacek W Sikora ; Paul M Thomas ; Joshua Levitsky, 4 ; Neil L Kelleher ; Proteomics Center of Excellence, Northwestern University, Evanston, IL; Proteomics Center of Excellence, Northwestern University, Evanston, IL; Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; 4 Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL WP Towards Routine Sub 00uL Serum/Plasma Analysis of Hepcidin-5 using LC/MS/MS; Joel Gummer,, ; Ben Hunter, ; Robert Trengove,, 4 ; School of Veterinary and Life Sciences, Murdoch University, Perth, Australia; Separation Science and Metabolomics Laboratory, Murdoch University, Perth, Australia; Metabolomics Australia, WA Node, Perth, Australia; 4 Murdoch University, Murdoch, WA WP Simultaneous Determination of Ceftazidime and Avibactam in Human Plasma by LC/MS; Xiaohua Li ; Xu Allan ; Keystone Bioanalytical, Inc. North Wales, PA WP 4 Integrating Glycoproteomics in the Comprehensive Multi-Omics Profiling of Obesity-mediated Progression WP 5 WP 6 to Type II Diabetes; Christine Yeh; Stanford, California An ABRF-PRG study: Identification of Low Abundance Proteins in a Highly Complex Protein Sample; Susan Van Riper ; Chen Emily ; Allis Chien ; Henriette Remmer 4 ; Paul M. Stemmer 5 ; Wang Yan 6 ; Pratik Jagtap 7 ; University of Minnesota Informatics Institute, University of Minnesota, Minneapolis, MN; Herbert Irving Comprehensive Cancer Center & Department of Pharmacology, Columbia University Medical Center, New York, NY; Stanford University Mass Spectrometry, Stanford University, Stanford, CA; 4 Department of Biological Chemistry, University of Michigan, Ann Arbor, MI; 5 Institute of Environmental Health Science, Wayne State University, Detroit, MI; 6 Proteomics Core Facility, University of Maryland, College Park, MD; 7 Center for Mass Spectrometry and Proteomics, University of Minnesota, St. Paul, MN Particle-based N-linked Glycan Analysis of Selected Serum Proteins using Non-Glycosylated Binders as a Cancer Array Assay; Isabella Karlsson ; Anna Sroka- Bartnicka ; Alessandro Quaranta ; Lorena Ndreu ; Matthijs Pijnappel ; Gunnar Thorsén ; Department of Environmental Science and Analytical Chemistry, Stockholm University, Stockholm, Sweden Carbohydrates (Glycans) 7-8 WP 7 Separation of Carbohydrate and Glycopeptide Isomers using Ion Mobility-Mass Spectrometry; Johanna Hofmann, ; Heung Sik Hahm ; Weston B. Struwe 4 ; Hannes Hinneburg, ; Daniel Kolarich, ; Peter H Seeberger, ; Kevin Pagel ; Fritz-Haber-Institut der Max-Planck- Gesellschaft, Berlin, Germany; Freie Universität Berlin, Berlin, Germany; Max Planck Institute of Colloids and Interfaces, Potsdam, Germany; 4 Oxford University, Oxford, UK WP 8 Non-Arbitrary Scoring Model for Structural Identification of Glycosaminoglycan Tandem MS; Jiana Duan ; Jon Amster ; University of Georgia, Athens, GA; University of Georgia, Chemistry Department Athens, GA WP 9 In-depth Analysis of Non-derivatized N-linked Glycans Using Ion Chromatography- Orbitrap Mass Spectrometry; Zoltan Szabo ; Junhua Wang ; Yury Agroskin ; Rosa Viner ; Julian Saba ; Thermo Fisher Scientific Japan, Yokohama, Japan; Thermo Fisher Scientific Inc, San Jose, CA; Thermo Fisher Scientific, San Jose, CA WP 0 Hydrophilic Interaction Liquid Chromatography-Mass Spectrometric Imaging Platform for N-glycan Relative Quantitation using Stable-Isotope Labeled Hydrazide Reagents; Zhengwei Chen ; Xuefei Zhong ; Tie Cai ; Yatao Shi ; Xinxiang Zhang 4 ; Lingjun Li ; University of Wisconsin Madison, Madison, WI; University of Wisconsin-Madison, Madison, US; Peking University, Beijing, China; 4 Chinese Academy of Sciences, Shanghai, China WP A Comprehensive Mass Spectrometric Workflow to Investigate Glycosylation Impact on Viral Antigenic Sites; Edward Bodnar ; Lisa Parsons ; Yanming An ; John F Cipollo ; Human and Health Services, U.S. Food and Drug Administration, Division of Bacterial, Parasitic and Allergenic Products, Laboratory of Bacterial Polysaccharides, Silver Spring, USA WP Mobilizing the Library: Using IMS-MS Data to Supplement GU Library Searching for Glycan Identification; William Alley ; Ying-Qing Yu ; Waters Corp., Milford, MA WP Glycosaminoglycan Peak Searching: A Novel GAG- Specific Method for Automated Tandem Mass Spectra Analysis; John D. Hogan ; Yu Huang ; Cheng Lin ; Joshua Klein ; Luis Carvalho ; Chengli Zong 4 ; Geert-Jan Boons 4 ; Joseph Zaia ; Program in Bioinformatics, Boston University, Boston, MA; Boston University School of Medicine, Boston, MA; Department of Mathematics & Statistics, Boston University, Boston, MA; 4 Complex Carbohydrate Research Center UGA, Athens, GA WP 4 Speeding up the High Throughput Searches for Glycan Analysis; Ningombam Sanjib Meitei ; Arun Apte ; Rupanjan Goswami ; Julian A Saba ; PREMIER Biosoft, Indore, India; PREMIER Biosoft, Palo Alto, CA; Thermo Fisher Scientific, San Jose, CA WP 5 Comprehensive Assessment of Derivatization Strategies for LC-MS/MS Analysis of N-glycans; Shiyue Zhou ; Xue Dong ; Yehia Mechref ; Texas Tech University, Lubbock, TX WP 6 Multiplex LC-MS Analysis of Isotopically Permethylated N-glycans Derived From Biological Samples; Xue Dong ; Shiyue Zhou ; Yehia Mechref ; Texas Tech University, Lubbock, Texas WP 7 Capillary Electrophoresis Separation of Glycosaminoglycans Followed by Tandem Mass Spectrometry; Morgan Stickney ; Patience Sanderson ; Robert J Linhardt ; Jon Amster ; University of Georgia, Chemistry Department Athens, GA; Rensselaer Polytechnic Institute, Troy, NY PAGE 4 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

135 WEDNESDAY POSTERS WP 8 Glyconote: A Software for the Automated Interpretation of Glycomics Data from Tandem Mass Spectrometry; Mingqi Liu ; Guy Treves ; Andres Guerrero ; Matthew Amicucci ; Jasmine Davis ; Lauren D Wu ; Pengyuan Yang ; Carlito B Lebrilla ; Fudan University, Shanghai, China; UC Davis Chemistry Department, Davis, CA WP 9 Optimization of Dual Modifications Strategy for Simultaneous Characterization of Neutral and Sialylated N-Glycans by LC-MS/MS; Haiying Li ; Patricia Cho ; Stephen Kostel ; John Froehlich ; Richard Lee ; Boston Children s Hospital, Harvard Medical School Boston, MA WP 0 Semi-automated Glycan Screening and Quantitative Analysis of Longitudinal Plasma Samples; Elizabeth S. Hecht ; Alison Motsinger-Reif ; Brendan MacLean ; James N Petitte ; Michael J MacCoss ; David C Muddiman ; North Carolina State University, Raleigh, NC; University of Washington, Seattle, WA WP Sialyl Linkage-Specific Glycan Profiling using Solid- Phase SALSA: A Simple and Versatile Derivatization Approach; Takashi Nishikaze ; Hiroki Tsumoto ; Yuzo Yamazaki ; Shinichi Iwamoto ; Yuri Miura ; Koichi Tanaka ; Shimadzu Corporation, Kyoto, Japan; Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan WP MS Based Method to Quantify Rheumatoid Arthritis Serum Glycosaminoglycans Using nano UPLC-ionkey MS/MS on a Xevo G Q Tof; Youjin Seo ; Armann Andaya ; Julie A Leary ; University of California Davis, Davis, CA WP Detailed Structure Elucidation of the N-linked Octasaccharide of the Archaeon Methanosarcina mazei by Mass Spectrometry; Deborah R. Leon ; Cheng Lin ; Yi Pu ; John R Haserick ; Rebecca S Glaskin ; Rachel R Ogorzalek Loo ; Joseph A Loo ; Robert Gunsalus ; Catherine E Costello ; Boston University School of Medicine, Boston, MA; UCLA, Los Angeles, CA WP 4 Glyc: A New Tool for Glycan Structure Elucidation and Characterization; Eric Joyce ; Jinshan Gao ; Montclair State University, Montcalir, NJ WP 5 Developmental Profiles of Gangliosides in Prefrontal Cortex of Human Brain via Negative Ion Mode Nano-LC/ MS and LC/MS/MS; Injung Ji, ; Jae Yun Hwang, ; Su Min Kim, ; Dan Bi Park, ; David Bradley ; Hyun Joo An, ; Asia Glycomics Reference Site, Chungnam National University, Daejeon, Korea; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea; Agilent technologies Inc, Santa Clara, CA WP 6 Tailoring Glycan Hydrazide Tagging Reagents for MS Functionality; James McCord ; David C Muddiman ; North Carolina State University, Raleigh, North Carolina WP 7 Acid-Induced Fucose Migration; Yi Pu ; Yang Tang ; John Haserick ; Catherine E Costello ; Cheng Lin ; Boston University, Boston, MA; Boston University School of Medicine, Boston, MA WP 8 Automated N-Glycan Sample Preparation with an Instant Glycan Labeling Dye for Mass Spectrometry; Ted Haxo ; Aled Jones; Michael J Kimzey ; Emily Dale ; Sergey vlasenko ; Steve mast ; ProZyme, Hayward, CA Disease Biomarkers 9-5 WP 9 Identification of Novel Biomarker Candidates for Diagnosis of Follicular Carcinoma; Xianyin Lai; Indiana University School of Medicine, Indianapolis, IN WP 40 Identification of a CNS-specific Proteome Biomarker for Clinical Relapses and Progression of Multiple Sclerosis using a Systems-Biology Approach; Itay Raphael ; Carol A Huizar ; Yanyan Qu ; Wendell P Griffith ; Thomas G Forsthuber ; Department of Biology, University of Texas at San Antonio, San Antonio, TX; Department of Chemistry, University of Texas at San Antonio, San Antonio, TX WP 4 Biomarkers of Early Chronic Obstructive Pulmonary Disease (COPD) in Smokers and Former Smokers - A Comparison of Two Methods; Karin Barbara Sahlin ; Johan Malm ; Mikael Truedsson, ; May Bugge ; Elisabet Wieslander ; Maria Yokaleva ; Magnus Dahlbäck ; Roger Appelqvist ; Thomas Fehniger ; György Marko-Varga ; Lund University, Lund, Sweden; Lund University, Lund, Sweden; Örestadskliniken, Malmö, Swden WP 4 Large-Scale Analysis of Protein Conformational Changes for Biomarker Discovery; Fang Liu ; Michael C Fitzgerald ; Duke University, Durham, NC WP 4 Study of Traumatic Brain Injury Biomarkers by Mass Spectrometry-Based Proteomics; Manasi Mangaonkar ; Richard A Yost ; Kari Green ; Kevin Wang ; University of Florida, Gainesville, FL WP 44 Lipidomics Approach in Biliary Atresia for a Potential Diagnostic Method Based on Mass Spectrometry; Cibele Esteves ; Diogo Noin de Oliveira ; Carlos Fernando Odir Rodrigues Melo ; Luciana Di Paolo ; Gabriel Hessel ; Rodrigo Ramos Catharino ; University of Campinas, Campinas, Brazil WP 45 Neonatal Neurodegeneration in 5XFAD Alzheimer s Disease Transgenic Mouse Model; Aise Rumeysa Mazi, ; Aysegul Sumeyye Arzuman, ; Mehmet Ozansoy, ; Ahmet Tarik Baykal 4 ; Regenerative and Restorative Medicine Research Center, REMER, Istanbul, Turkey; Institute of Health Science, Istanbul Medipol University, Istanbul, Turkey; Department of Physiology, International School of Medicine, İstanbul Medipol University, Istanbul, Turkey; 4 Acibadem University, Ataşehir-Istanbul WP 46 A Proteomic Investigation of the Role of Neurotoxins Linked to Amyotrophic Lateral Sclerosis Disease Pathogenesis; Joshua Beri ; Michael S Bereman ; NC State University, Raleigh, NC WP 47 Prediction of Response to Sorafenib in Hepatocellular Carcinoma: A Multimarker Panel of Potential Biomarkers by Multiple Reaction Monitoring-Mass Spectrometry; Hyunsoo Kim ; Injoon Yeo ; Su Jong Yu ; Taesung Park ; Jung-Hwan Yoon ; Youngsoo Kim ; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea; Department of Statistics, Seoul National University, Seoul, Korea WP 48 Simultaneous Quantification of Tryptophan- Relatedmetabolitesas Biomarkers for Prediabetes; Norihide Yokoi ; Ritsuko Hoshikawa ; Toshiya Matsubara ; Susumu Seino ; Kobe University Graduate School of Medicine, Kobe, JPN; SHIMADZU Corporation, Kyoto, JPN WP 49 Comparison of Plasma Protein Profiles of Selected Cardiovascular Diseases by itraq Quantification; Helena Rehulkova ; Alena Myslivcova Fucikova ; Pavel Rehulka ; Radek Pudil ; Jiri Stulik ; Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic; st Department of Internal Medicine Cardioangiology, Faculty Hospital, Hradec Kralove, Czech Republic WP 50 Proteomics Analysis of Aged Healthy Human White Blood Cells; Ceereena Ubaida-Mohien ; Alexey Lyashkov ; Arsun Bektas ; Robert Wersto ; Nan Ping Weng ; Ranjan Sen, ; Luigi Ferrucci ; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD - Maryland; Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD WP 5 Cardiovascular Disease - Metabolic Syndrome Induced Protein/PTM Changes; Mark E. McComb ; Stephen A. A Whelan ; Chunxiang Yao ; Jessica B. Behring ; Jean L. Spencer ; Christian F. Heckendorf ; Nancy M. Leymarie ; 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

136 GENERAL WEDNESDAY INFORMATION POSTERS Deborah A. Siwik ; Wilson S. Colucci ; Richard A. Cohen ; Markus M. Bachschmid ; Catherine E. Costello ; Boston University School of Medicine, Boston, MA WP 5 An Adductomics Pipeline for Untargeted Analysis of Post Translational Modifications; Hasmik Grigoryan ; William Edmands ; Sixin S Lu ; Yukiko Yano ; Anthony Iavarone ; Evan R Williams ; Stephen M Rappaport ; University Of California, Berkeley, CA; University of California, Berkeley, CA WP 5 Localized Quantitative Proteomics on Amyloid Plaques Microdissected from Postmortem Tissue to Characterize Difference between Rapidly Progressive and Typical Alzheimer s Disease; Shruti Nayak ; Eleanor Drummond ; Manor Askenazi ; Arline Faustin ; Geoffrey Pires ; Richard Hickman ; Jiri Safar ; Thomas Wisniewski ; Beatrix M Ueberheide ; NYULMC, New York, NY; Biomedical Hosting LLC, Arlington, MA; Case Western Reserve University, Cleveland, OH Drug Discovery/DMPK/ADME (General) WP 54 High Throughput Screening of Competitive Binders for Target Proteins using Rapid LC-MS Analysis; Kasun Imaduwage ; Eden P Go ; Heather Desaire ; University Of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS WP 55 Implementation of Mass Spectrometry into High Throughput Screening Workflows to Improve Hit Quality; Gregory Adam ; Juncai Meng ; Adam Amoss ; Amita Patel ; Daniel Riley ; Victor Uebele ; Jeffrey Hermes ; Merck & Co., Inc., North Wales, PA; Merck & Co., North Wales, PA WP 56 Application of High-Throughput Micro-Flow LC/MS/MS to a Metabolic Stability Screening Workflow; Brendon Kapinos ; John S Janiszewski ; Mary Piotrowski ; Wayne Lootsma ; Steven Ainley ; William Schramm ; Hui Zhang ; Pfizer, Groton, CT; Sound Analytics, Niantic, CT WP 57 Ultra High Throughput Drug Discovery Screening by MALDI-TOF Mass Spectrometry Exceeding One Million Samples per Week; Peter S. Marshall ; Michelle Pemberton ; Carl Haslam ; Gabriella Clarke ; Jessica Chandler ; Adrian Dunn ; Neil Hardy ; Melanie Leveridge ; GlaxoSmithKline, Stevenage, UK WP 58 High Throughput Screening- ADME; Transitioning from Triple Quadrupole to High Resolution Accurate Mass Spectrometry; Jason Causon ; Graeme Clark ; SCIEX, Warrington, UK; Cyprotex, Macclesfield, UK WP 59 Utilizing High Resolution Accurate Mass Spectrometry for Quantification, MRMHR and SWATH Acquisition Workflows; Jason Causon ; Lee Mendil ; Donna-Michelle Smith ; Neil Devenport ; Thomas Knapman ; Milla Neffling ; SCIEX, Warrington, UK; CRUK Cambridge Institute - University Of Cambridge, Cambridge, UK WP 60 Simultaneous Analysis of Supernatant Components of Cell Culture using Triple Quadrupole LC/MS/MS; Qiaoxia Liu ; Hongyuan Hao ; Yuling Song ; Qiang Li ; Zhao Liu ; Taohong Huang ; Yuki Hashi ; Shimadzu, Shanghai, CHINA WP 6 Assay Development of in vitro Blood-Brain Barrier Models for Drug Permeability Screening; Lie Min ; Jennifer L. Mantle ; Kelvin H. Lee ; Department of Chemical and Biomolecular Engineering and Delaware Biotechnology Institute, University of Delaware, Newark, DE WP 6 Labeled Compound Detection Using Compound Discoverer Pattern Scoring From High Resolution Mass Spectrometry; Caroline Ding ; Tim J Stratton ; Martin Strohalm ; Ji Ma ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Bremen, DE; Amgen, Inc. South San Francisco, CA WP 6 Evaluation of Ion Mobility Enabled Collisional Cross Section Measurements for the Differentiation of Acyl and Phenolic Glucuronide Metabolites; Catherine Holdsworth ; Richard Clayton ; Daniel Weston ; Nick Tomczyk ; Martin Palmer ; Darren Hewitt ; Covance, Harrogate, UK; Waters, Wilmslow, UK WP 64 Resolution and Characterisation of Co-eluting Isomeric Metabolites by Collision Cross Section Measurements using a Novel Geometry Travelling-Wave IMS-QTof Mass Spectrometer; Richard Clayton ; Catherine Holdsworth ; Daniel Weston ; Nick Tomczyk ; Martin Palmer ; Darren Hewitt ; Covance, Harrogate, UK; Waters, Wilmslow, UK WP 65 Automatic Calculation and Layout of MS/MS Fragmentation Pathways; Ismael Zamora ; Blanca Serra ; Morettoni Luca ; Lead Molecular Design, S.L., Sant Cugat del Valles, Barcelona; Molecular Discovery, Ltd London, UK; Molecular Discovery, London, UK WP 66 Drug Stability Study using Q Exactive Bench Top Mass Spectrometer; Jie Ding ; Thomas Leitzinger ; Kate Comstock ; PPD Inc, Middleton, WI; Thermo Fisher Scientific, San Jose, CA WP 67 Novel Drug Target Identification via Label Free Differential Mass Spectrometry and Thermal Stability Profiling; Harris Bell-Temin ; Steven J Mullett ; David Zaidins ; Andrey Bondarenko ; Mark E Schurdak ; Andrew Michael Stern ; D. Lansing Taylor ; Nathan A Yates ; School of Medicine, University of Pittsburgh, Pittsburgh, PA; Drug Discovery Institute, University of PIttsburgh, Pittsburgh, PA; Infoclinika, Seattle, WA WP 68 Quantitative Kinome Analysis as a Tool for Discovering Molecular Targets for Cancer Therapy; Weili Miao ; Yongsheng Xiao ; Yinsheng Wang ; University of California - Riverside, Riverside, CA; University of California, Riverside, CA WP 69 Rapid Rank Ordering of Compounds in Mixtures by Orthogonal Affinity Selection Mass Spectrometry; Christine L. Andrews ; Matthew P Richards ; Jacqueline Hicks ; John Caldwell ; Jared Cumming ; Andrew Stamford ; Corey Strickland ; Peter Dandliker ; Merck & Co, Kenilworth, NJ WP 70 Platform Agnostic Data Processing Routine for Targeted and Untargeted Metabolite Identification in Drug Discovery; Richard Lee ; Vitaly Lashin ; Alexandr Sakarov ; ACD/Labs, Toronto, Canada; ACD/Labs, Moscow, Russia WP 7 A MS Approach to Understand the Most Metabolically Labile Amide Bonds in Peptides; Ismael Zamora ; Tatiana Radchenko ; Elisabeth Ortega ; Lead Molecular Design S.L., Sant Cugat de Valles, Spain WP 7 Identification of Active Herbal Ingredients by Affinity Selection Mass Spectrometry Coupled with Ultrafiltration; Yan Jin ; Fangzhou Xie ; Lei Fu ; Shanghai Jiao Tong University, Shanghai, China WP 7 Glue Medicines Analysis by UHPLC Tandem Quadrupole-Time of Flight Mass Spectrometry; Hu Nan ; Zuo Shuai ; Du Wei ; Bo Tao ; Agilent Technologies (China) Limited, Beijing, China WP 74 Rapid Determination of Protein Binding Affinity Using Solid Phase Micro Extraction; Emily Barrey ; Craig Aurand ; David Bell ; Sara Smith ; Sigma Aldrich, Bellefonte, PA WP 75 Biochemical Assay Development Using Novel MALDI High-Throughput Screening System; Sergei Dikler ; Paul J Kowalski ; Bruker Daltonics, Billerica, MA; Bruker Daltonics, Inc., Billerica, MA WP 76 Assessment of Chemical Probes for Identification of Cellular Targets of Small Molecules; Jeffrey Martin ; Mercedes Beyna ; Ceren Korkut ; Rajesh Prakash ; Jeffery Vessels ; Kevin Guckian ; Erik Hett ; Peter Juhasz ; Biogen, Cambridge, MA PAGE 6 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

137 WEDNESDAY POSTERS Energy: Biofuels and Algae WP 77 Evaluating the Impact of Freezing Biologic Fluids on Drug Distribution and Its Impact on Frozen Aliquotting for Quantitative Drug Analysis; Glenn Smith ; Joseph Fraone ; Graham Long ; Tanya Shih ; Cryoxtract Instruments, Woburn, MA WP 78 Detection of Creatine from Single Algae Cells using Mass Spectrometry; Mei Sun ; Ning Pan ; Boris Wawrik ; Zhibo Yang ; The University of Oklahoma, Norman, OK WP 79 Quadrupole Time-of-Flight Tandem Mass Spectrometry Identifies and Quantifies Eugenol in Extraction from Bio-oils Into Diesel; Kelsey Boes ; Nelson R Vinueza ; Yufei F Chen ; Hoyong Kim ; Park Sunkyu ; North Carolina State University, Raleigh, NC WP 80 Application of Molecular Dynamic Simulation to Improve the CCS Calculation Accuracy of Aromatic Compounds with Long Alkyl Chains; Arif Ahmed ; Dongwan Lim ; Hugh I. Kim ; Sunghwan Kim, ; Kyungpook National University, Daegu, Republic of Korea; Korea University, Seoul, Republic of Korea; Green-Nano Materials Research Center, Daegu, Republic of Korea WP 8 Characterization of a β-o-4 Trimeric Lignin Model Compound and Post Fenton Chemistry Products using HRAM Mass Spectrometry; Fan Huang ; Bert C Lynn ; University of Kentucky, Lexington, KY WP 8 Investigating the Mechanism of Lipid Body Obesity in C. reinhardtii under Nitrogen Starvation Conditions using High Resolution Mass Spectrometry; Carter Lantz ; Ryan Rho ; Jeremy Sieker ; Matthew Brantley ; Alireza Abdolvahabi ; James Chang ; Sung-Joon Kim ; Touradj Solouki ; Baylor University, Waco, TX WP 8 Effect of Alkali Metals on Pyrolysis Kinetics of Carbohydrates Using dapci-tof MS; Kristen O Connor ; Carolyn Hutchinson ; Young Jin Lee ; Iowa State University, Ames, IA WP 84 Characterization of Fast Pyrolysis Oil from Pine Feedstock; Ashley Wittrig ; Ross Mabon ; Boris Sheludko ; ExxonMobil, Annandale, NJ WP 85 Exploring the Mechanisms of Fast Pyrolysis of Hemicellulose via Tandem Mass Spectrometry and Quantum Chemical Calculations: A Model Compound Study; Priya Murria ; John Degenstein ; Mckay Easton ; Hanyu Zhu ; John Nash ; Rakesh Agrawal ; Nicholas Delgass ; Fabio Ribeiro ; Kenttämaa Hilkka ; Purdue University, West Lafayette, IN WP 86 Chemical Reactions Causing Instability in Wood- Derived Bio-Oils: Enhanced Detection of Aldehydes using Peracetylation with Pyridine or DMAP; Elizabeth A. Stemmler ; Paige E. Speight ; Mason A. Bosse ; Matthew J. Rasmussen ; Bowdoin College, Brunswick, ME; Bowdoin College, Brunswick, ME WP 87 Integrated Omics Reveals the Details of Metabolic Adaptation of Clostridium thermocellumatcc-7405 Grown on Switchgrass; Suresh Poudel, ; Richard J Giannone ; Miguel Rodriguez ; Babu Raman ; Madhavi Z Martin ; Nancy L Engle ; Nookaew Intawat ; Steven D Brown ; Timothy J Tschaplinski ; David Ussery ; Hettich L Robert ; Oak Ridge National Laboratory, Oak Ridge, TN; University of Tennesse, Knoxville, TN; Dow AgroSciences, Indianapolis, IN WP 88 Large scale Identification of Polymorphic Peptides via Cross-Species Spectral Networks in Microbial Proteomics; Seungjin Na ; Sam Payne ; Nuno Bandeira ; University of California San Diego, La Jolla, CA; Pacific Northwest National Lab, Richland, WA WP 89 Development of GeLC-MRM Approach to Study Carbon Concentrating Mechanism during Nitrogen Starvation in Chlorella sp IITG FC; Vineeta Rai ; Deepti Bhandarkar ; Ajit Datar ; Sanjeeva Srivastava ; Indian Institute of Technology Bombay, Mumbai, India; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, India Environmental Analysis: Water Quality WP 90 Development of Method for Quantification of Iodoacetic Acids in Drinking Water Using GC/EI-MS/MS; Hannah Liberatore ; Amy A. Cuthbertson ; Susan D Richardson ; University of South Carolina, Columbia, SC WP 9 Water Quality Growth and Change, Advanced Technology Method Change to Prescribe a Desirable Future to US EPA Method 5, (004); Andrew Eaton ; Konjit Tadigo ; Charles Grady ; Ron Honnold ; Eurofins Eaton Analytical Inc, Monrovia, CA; Agilent Technologies, Prescott, AZ WP 9 A New Approach for Identification of Unknown Disinfection Byproducts in Drinking Water using Multiplex Solid Phase Extraction /HPLC-tandem Mass Spectrometry; Xing-Fang Li ; Yanan Tang ; Guang Huang ; Lindsay Jmaiff ; Ian Vander Meulen ; University of Alberta, Edmonton, AB; University of Alberta, Edmonton, Canada WP 9 Direct Analysis of PFAAs in Water using Differential Mobility Spectrometry-Mass Spectrometry; Matthew Noestheden ; KC Hyland ; Simon Roberts ; Chris Higgins ; SCIEX, Concord, ON; SCIEX, Redwood City, CA; Colorado School of Mines, Golden, CO WP 94 Significantly Improved Detection in Volatile Organic Analysis (VOA) of Water using Static Headspace and GCMS with a High Efficiency Source; Harry Prest ; Melissa Churley ; Peter Gautschi ; Agilent Technologies, Santa Clara, CA; Agilent Technologies, Santa Clara, CA; Agilent Technologies Sales & Services GmbH, Waldbronn, Deutschland WP 95 Increased Capabilities for the Analysis of Hormones in Drinking and Waste Water using SPE and LC/MS/ MS; Xianrong (Jenny) Wei ; Sean Orlowicz ; Phenomenex, Torrance, ca; Phenomenex, Torrance, CA WP 96 Analysis and Fingerprinting of Non-Ionic Surfactants in Hydraulic Fracturing Waters by Ion Mobility Mass Spectrometry; E. Michael Thurman ; Imma Ferrer ; Jerry Zweigenbaum ; Aaron Boice 4 ; John Fjeldsted 4 ; University of Colorado, Boulder, CO; University of Colorado, Boulder, Colorado; Agilent Technologies, Little Falls, DE; 4 Agilent Technologies, Santa Clara, CA WP 97 Cloud-based Analysis of Complex Sample Systems for Outlier and Trend Analysis in the Context of Water Monitoring; Ralf Tautenhahn ; Tim J Stratton ; Dipankar Ghosh ; Thermo Fisher Scientific, San Jose, CA WP 98 Two Birds with One Stone: Simultaneous GC/MS Analysis of Volatile and Semivolatile Water Pollutants; Olga V Polyakova ; Dmitry Mazur ; Viatcheslav Artaev ; Albert T. Lebedev ; Moscow State University, Moscow, Russia; LECO Corporation, St Joseph, MI; Moscow State University, Moscow, Moscow WP 99 Unknown Profiling of Drinking Water Using High Resolution LC-MS/MS and New Software; Caroline DING ; Anastasia Kalli ; Charles Yang ; Tim J Stratton ; Thermo Fisher Scientific, San Jose, CA WP 00 Environmental Screening of Water Samples utilizing Ion Mobility Enable High Resolution Mass Spectrometry; Lauren Mullin ; Douglas Stevens ; Gareth Cleland ; Adam Ladak ; Waters, Milford, MA WP 0 Using Mass Spectrometry to Detect Silanol Compounds in Water from the International Space Station; Jeffrey A. Rutz ; C.K. Mike Kuo ; James T. Alverson ; William T. Wallace ; Daniel B. Gazda ; Wyle Science, Technology, and Engineering Group, Houston, TX; NASA Johnson Space Center, Houston, TX 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

138 GENERAL WEDNESDAY INFORMATION POSTERS WP 0 Quantitative Analysis of Nonylphenol Ethoxylates in Surface Water with UHPLC and HRAM Mass Spectrometry; Cindy Lai ; Claudia Martins ; Keith Waddell ; Mark Tracy ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Sunnyvale, CA WP 0 MALDI-TOF MS for Identification of Organic-Degrading Bacteria in Contaminated Groundwater near Unconventional Natural Gas Extraction Sites; Inês C. Santos ; Doug D. Carlton Jr. ; Zacariah L. Hildenbrand, ; Kevin A Schug, ; Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX; Inform Environmental, LLC, Dallas, TX; Affiliate of the Collaborative Laboratories for Environmental Analysis and Remediation, The University of Texas at Arlington, Arlington, TX WP 04 Screening for Pollutants in Water using a GC/MSD Extractor Source with MassHunter Deconvolution Software and Customized Reporting; Chris Sandy ; Angela Henry ; Bruce Quimby ; Lei Tao ; Sue Zhang ; Vadim Kalmeyer ; Sun Li ; Agilent Technologies, Santa Clara, CA; Agilent Technologies, Little Falls, DE WP 05 Identification of Halobenzoquinones, an Emerging Class of Disinfection By-Products in Drinking Water, using High Resolution Mass Spectrometry; Wei Wang; University of Alberta, Edmonton, AB WP 06 Medical Imaging Compounds as a Source for New Iodo- Disinfection Byproducts in Drinking Water; Christina M Joseph ; Cristina Postigo ; Michael J Plewa ; Thomas A Ternes 4 ; Friedrich Wendel 4 ; Christian Luetke-Eversloh 4 ; Stephen E Duirk 5 ; Susan D Richardson ; University of South Carolina, Columbia, SC; Institute of Environmental Assessment and Water Research (IDAEA-CSIC) Water and Soil Quality Research Group, Department of Environmental Chemistry, Barcelona, Spain; University of Illinois at Urbana-Champaign, Urbana-Champaign, IL; 4 Federal Institute of Hydrology (BfG), Koblenz, Germany; 5 University of Akron, Akron, OH Food Safety: Other Contaminants (Part ) 07-5 WP 07 Characterization of the Volatile Degradation Products of Soybean Oil after Frying Process by HS-SPME-GC-MS; Ya-Ting Tsai ; Maw-Rong Lee ; Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan; National Chung-Hsing University, Taichung, Taichung WP 08 Non-targeted Analysis Approach for Distinguishing of Various Vegetable Oils and Adulterated Oils using HS-SPME-GC-MS; Yu-Hao Chen ; Maw-Rong Lee ; Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan; National Chung-Hsing University, Taichung, Taichung WP 09 Significant Robustness Improvements of PAHs Analysis in Palm Oil using the Self-Cleaning Ion Source (SCIS) in a GC/MS/MS System; Michel Lesieur ; Elizabeth Almasi ; Terry Sheehan ; Agilent Technologies, Les Ulis, France; Agilent Technologies, Santa Clara, CA WP 0 Analysis of Fish Oil for Contaminants by LC Time-of- Flight Mass Spectrometry with All Ions Confirmation; Sue Dantonio ; Joan Stevens ; Agilent Technologies, Flatonia, TX; Agilent Technologies, Wilmington, DE WP Quality Control of Cooking Oils by Metabolic Profiling and Spectral Fingerprinting; Chi Yuen Cheung; HKUST, Hong Kong WP Direct Analysis of Brominated Vegetable Oil in Commercial Soft Drinks by LC-MS; Priyanka Chitranshi ; Goncalo Gamboa Da Costa ; US FDA NCTR, Jefferson, AR WP Determination of Phthalates in Vegetables by GPC GCMS; Zhang Xi; SHIMADZU (CHINA) CO., LTD., Beijing Branch, Beijing, China WP 4 Representative, Two-Gram Incurred Food Samples using mini-quechers, Cryomilling and GC/MS/ MS Analysis with a High Efficiency Ion Source; Joan Stevens ; Melissa Churley ; Agilent Technologies, Wilmington, DE; Agilent Technologies, Santa Clara, CA WP 5 Identification of Contaminants in Powdered Beverages by Direct Extraction Thermal Desorption GC/MS; Ronald Shomo ; Christopher W Baker ; John Manura ; Scientific Instrument Services, Ringoes, NJ WP 6 Simultaneous Separation and Determination of Fifteen Organic UV Filters in Sunscreen Cosmetics by HPLC- ESI-MS/MS; Qiang Ma ; Xianshuang Meng ; Guangcheng Xi ; Chinese Academy of Inspection and Quarantine, Beijing, China WP 7 Determination of Chlorinated Compounds Arising from the Thermal Degradation of Sucralose; Diogo Noin de Oliveira ; Maico Menezes ; Rodrigo Ramos Catharino ; Innovare Biomarkers Laboratory - UNICAMP, Campinas, Brazil WP 8 A High Throughput, Low Cost and Green Approach to Automated Extraction, Clean Up, and Concentration for Same Day POPs Analysis; Tom Hall ; Ruud Addink ; Fluid Management Systems, Watertown, MA WP 9 Total Residue Analysis of Glyphosate and Three Metabolites in Soy and Milk-Based Nutritional Ingredients by Liquid Chromatography Mass Spectrometry; Stefan Ehling ; Todime Reddy ; Abbott Nutrition, Columbus, OH WP 0 Infant Formula and Milk: Chlorinated Dioxins and Furans Analysis Using Automated Extraction and Column Chromatography; Aleks Sharapov ; Rudolf Addink ; Toxic Report, Watertown, MA WP Simultaneous Determination of Total vitamins B, B, B, B5, and B6 and Total Folate in Infant Formula and Related Nutritionals; Nicholas Cellar ; Todime Reddy ; Abbott Nutrition, Columbus, OH WP Simultaneous Determination of Choline, Carnitine, and Myo-inositol by LC-MS/MS; Jonathan Draher ; Nicholas A Cellar ; Todime Reddy ; Abbott Nutrition, Columbus, OH; Abbott Nutrition, Columbus, OH WP Multi-residue Antibiotic Analysis of Dairy Products using UHPLC-MS/MS with a Heated Laminar Flow Interface and a Modified QuEChERS Method; Avinash Dalmia ; Sharanya Reddy ; Thomas P White ; Tong Chen ; Wilhad Reuter ; David Welkie ; Lisa Cousins ; Joshua Ye ; Reza Javahery ; PerkinElmer Health Sciences, Inc., Shelton, CT; IONICS Mass Spectrometry, Bolton, Canada WP 4 Rapid Determination of Lactulose in Heat Treated Milk using Ultraperformance Convergence Chromatography Coupled with Mass Spectrometry; Fang Wen ; Yao Tian, ; Yongwei Xu ; Nan Zheng, ; Qinglong Sun ; Songli Li, ; Jiaqi Wang, ; Ministry of Agriculture Laboratory of Quality & Safety Risk Assessment for Dairy Products (Beijing), Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China; Ministry of Agriculture - Milk and Dairy Product Inspection Center (Beijing), Beijing, China; Waters Corporation, Shanghai, China WP 5 Mass Barcode-Based Signal Amplification for Highly Sensitive Multiplex Diagnosis of Allergy; Xiaoqin Zhong ; Liang Qiao, ; Natalia Gasilova ; Baohong Liu ; Hubert H Girault ; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Fudan university, Shanghai, China WP 6 Multi-Allergen Quantitation in Thermally Processed Foods by Liquid Chromatography Tandem Mass Spectrometry; Chelsea M. Coffey ; Christine H. Parker ; Timothy R Croley ; U.S. Food and Drug Administration, College Park, MD WP 7 Ultra-Fast Analysis of Allergens using Capillary Electrophoresis Coupled to Mass Spectrometry and Ultraviolet Photodissociation; Chien-Hsun Chen ; PAGE 8 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

139 WEDNESDAY POSTERS Andreas Krupke ; Monica Carrera ; Chad R Weisbrod ; Romain Huguet ; Shiaw-Min Chen ; Achim Karger ; Steve Williams ; Michael Wenz ; Andreas Huhmer ; Aran Paulus ; Daniel Lopez Ferrer ; Thermo Fisher Scientific, San Jose, CA; Marine Research Institute, Vigo, Spain; Thermo Fisher Scientific (South San Francisco), South San Francisco, CA - California WP 8 Chlorinated Dioxins, Furans and Biphenyls Analysis in Beverages Using Automated Extraction and Reduced Solvent Volume Column Chromatography; Matt Falkenstein ; Rudolf Addink ; Toxic Report, Watertown, MA WP 9 Rapid Analysis of Key Aflatoxins in Rice by Microwave Plasma Torch Mass Spectrometry; Tao Jiang ; Runzhi Zhou ; Zhiqiang Zhu ; Huanwen Chen ; East China Institute of Technology, Nanchang, China; East China University of Technology, Nanchang, Mainland WP 0 A High Sensitivity LC/MS/MS Method with QuEChERS Sample Pre-treatment for Determination of Aflatoxins in Milk Powders; Yin Ling Chew ; Jie Xing ; Guan Seng Leonard Lim ; Zhaoqi Zhan ; Shimadzu (Asia Pacific) Pte Ltd, Singapore; Shimadzu (Asia Pacific) Pte Ltd, Singapore, Singapore; School of Physical & Mathematical Science, Nanyang Technological University SPMS- CBC-0-0 Singapore, Singapore WP Development of Automated Screening and Quantitation Method on a Novel On-line SFE-SFC-MS/MS Platform (II) For Aflatoxins in Powdered Food; Jie Xing ; Yin Ling Chew ; Jun Xiang Lee ; Liw Wan Tung ; Zhaoqi Zhan ; Shimadzu (Asia Pacific) Pte Ltd, Singapore WP Simultaneous Analysis of Mycotoxins using Ultra- High Speed LC-MS/MS with a Pentafluorophenyl Column; Matsumoto Keiko ; Jun Watanabe ; Mochizuki Naoki ; Shimadzu Corporation, Kyoto, Japan; Shimadzu Corporation, Kyoto; Asahi Group Holdings, Limited Moriya, Japan WP LC-MS Analysis of Graviola and Other Neurotoxic Fruits; Kevin Tran ; Pushkar Shejwalkar ; Kenji Hara ; Ingrid de Moraes ; US FDA, Lenexa, KS; Tokyo University of Technology, Tokyo, JP; State University of Campinas, Campinas, Brazil WP 4 Rapid Development of Quantitative Method for Determination of Plant Growth Regulators and Streptomycin in Fruits using LC/MS/MS; Anant Lohar ; Shailendra Rane ; Ashutosh Shelar ; Purushottam Sutar ; Shailesh Damale ; Deepti Bhandarkar ; Rashi Kochhar ; Ajit Datar ; Jitendra Kelkar ; Pratap Rasam ; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, India WP 5 A Streamlined Processing Method for High Resolution Mass Spectrometric Data to Compare Food-Grade- Glycerin with Crude-Glycerins to Screen for Jatropha Toxins; Kithsiri B Herath ; Lauren Girard ; Renate Reimschuessel ; Hiranthi Jayasuriya ; Center for Veterinary Medicine/FDA, Laurel, MD Food omics MS Characterization of Food and Nutritional Supplements (Part ) 6-5 WP 6 Determination of Relative Amounts of iso- and n-alpha Acids in Beer without Prior Separation via Chemometric Analysis of MS/MS Data; Kevin D. Clark ; Joshua Driver ; Jon Amster ; Univ of Georgia, Athens, GA WP 7 SPME and Liquid-Liquid Extraction, Complimentary Methods for Analysis of Coffee Flavor Components by GCMS?; Emily P Erdman ; Stephanie I Allred ; Steven B Foster ; Ronald L Halterman ; University of Oklahoma, Dept. of Chem & Biochem Norman, OK WP 8 New Analytical and Statistical Tools to Study the Flavor-formation during the Roasting Process of Coffee Beans, Cacao Beans and Nuts; Sven Ehlert ; Hendryk Czech ; Jessalin Howell ; Romy Hertz-Schuenemann ; Chahan Yeretzian ; Thorsten Streibel ; Ralf Zimmermann 4,5 ; University of Rostock, Rostock, Germany; JM Smucker Inc., Orrville, Ohio; ZAHW, Zuerich, Switzerland; 4 University of Rostock, Rostock; 5 Helmholtz Zentrum Muenchen, Oberschleissheim, Germany WP 9 Understanding the Role of Origin, Roasting & Storage on Flavor Components in Coffee Employing Gas Chromatography Mass Spectrometry; Steven B Foster ; Emily P Erdman ; Melissa M Henniger ; Jessica R McConahey ; Gabrielle C Thng ; Ronald L Halterman ; University of Oklahoma, Dept. of Chem & Biochem Norman, OK WP 40 New Approach Analyzing Food Functionality using MALDI-MS-based Metabolic Profiling Technique: Evaluation of Green Tea Extracts; Chihiro Kawano ; Yoshinori Fujimura ; Ayaka Maeda-Murayama ; Eisuke Hayakawa ; Takanori Ishii ; Hiroyuki Wariishi, ; Daisuke Miura ; ICMRN, Kyushu University, Fukuoka, Japan; Faculty of Arts and Science, Kyushu University, Fukuoka, Japan WP 4 Non-targeted Modification-Specific Metabolomics Investigation of Glycosylated Metabolites in Tea (Camellia sinensis L.) by Liquid Chromatography High Resolution Mass Spectrometry; Weidong Dai, ; Meiling Lu ; Zhi Lin ; Shan Zhou ; Junfeng Tan ; Tea Research Institute of Chinese Academy of Agricultural Sciences, Hangzhou, China; Agilent Technologies (China) Limited, Beijing, China WP 4 Study of the Aroma Variation in Oolong Tea Processing by Solid-Phase Micro-Extraction and Gas Chromatography-Mass Spectrometry; Chengying Ma ; Shan Zhou ; Aiqing Miao ; Wenwen Wang ; Junxi Cao ; Tea Research Institute, Guangdong Academy of Agricultural Sciences, GuangZhou, China; Agilent Technologies Company. Ltd, Beijing, China WP 4 Analysis of Catechins in Brewed Tea by LC-TOF Mass Spectrometry; Robert J. Seward ; Jason Weisenseel ; Craig Young ; Wilhad M. Reuter ; PerkinElmer, Waltham, MA WP 44 Determination of Catechins in Tea by using in-situ Derivatization with a Direct Analysis in Real Time Source Equipped Mass Spectrometer; Robert Goguen ; Brian D. Musselman ; IonSense, Inc. Saugus, MA; IonSense, Inc., Saugus, MA WP 45 Foodomic Profiling of Vinegars in China with Metabolomics Workflow by Agilent 6545 UHPLC- ESI/QTOF; Shaozhen Wang ; Shan-An Chan ; Agilent Technology, Inc., Shanghai, China; Agilent Technology, Inc., Shanghai, China WP 46 High Sensitive LC-MS Analysis of Stevia Sweeteners Using a Polymer-Based Amino Column; Junji Sasuga ; Tomokazu Umezawa ; Leah Block ; Showa Denko K.K., Kawasaki, Japan; Shodex, Showa Denko America, Inc., New York, NY WP 47 Differences in the Composition of Milk during Lactation using High-Resolution Mass Spectrometry; Tatiane Melina Guerreiro ; Rodrigo Ramos Catharino ; Innovare Biomarkers Laboratory - UNICAMP, Campinas, Brazil WP 48 Analysis of Water Soluble Vitamins in Infant Formula using UHPLC with Tandem Mass Spectrometry and a Heated Laminar Flow Interface; Wilhad Reuter ; Sharanya Reddy ; Avinash Dalmia ; Tong Chen ; Thomas White ; Lisa Cousins ; Joshua Ye ; PerkinElmer, Shelton, CT; IONICS Mass Spectrometry, Bolton, Canada WP 49 Preliminary Investigation of Canadian Wheat Varieties Low Molecular Weight Glutenin Subunits Relative to Functional Gluten Strength; Dave Hatcher ; Bin Xiao Fu ; Ray Bacala ; Grain Research Laboratory, Canadian Grain Commission, Winnipeg, Canada 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 9

140 GENERAL WEDNESDAY INFORMATION POSTERS WP 50 Direct Separation and Quantitation of Amino Acids in Commercial Supplements and Nutraceuticals using LC- MS and HILIC Chromatography; Kimberly Dunn-Meynell ; Patricia Atkins ; Spex Certiprep, Metuchen, NJ WP 5 Reductive Amination Assistance to Quantitate Garlic Components in Isotope Dilution Analysis; Shih-Shin Liang; Kaohsiung WP 5 A Metabolomics Approach to Characterize Raw, Pasteurized and Ultra-High Temperature Milk using UPLC-QTOF-MS and Multivariate Data Analysis; Yangdong Zhang; Chinese Academy of Agricultural Sciences, Beijing, China Forensics (Part ) 5-78 WP 5 Mass Spectrometry by Paper Spray Ionization (PS-MS) A Swiss Army Knifein Forensic Chemistry; Eloilson Domingos ; Heloa Santos ; Lilian V Tose ; Radigya M Correia ; Flávia Tosato ; Thays C. Carvalho ; Christopher Thompson ; Paulo R Filgueiras ; Boniek G Vaz ; Wanderson Romão 4 ; UFES, Vitória, Brazil; UFG, Goiania, Goias; Bruker Daltonic, Billerica, MA; 4 IFES/UFES, Vila Velha, ES WP 54 Quantification of Cocaine and Its Adulterants by Paper Chromatography reveled bydragendorff Reagent and Paper Spray Ionization Mass Spectrometry; Heloa Santos ; Flavia Tosato ; Aryanne Souza Lima ; Eloilson Domingos ; Boniek G Vaz ; Wanderson Romão ; UFES, Vitória, Brazil; IFES, Vila Velha, Brazil; UFG, Goiânia, Brazil WP 55 Detection of NBOMe Designer Drugs on Blotter Paper using Ambient Ionization High Resolution Time-of- Flight Mass Spectrometry: A Forensic Case Study; Jamie Foss ; David Barajas ; Sabra Botch-Jones ; Frank Kero ; Craig Young ; Jason Weisenseel ; Maine Health & Environmental Testing Lab, Augusta, ME; Boston University School of Medicine, Boston, MA; PerkinElmer, Shelton, CT WP 56 Evaluating an All Ions Method for the Identification of NBOMEs on Seized Blotter Papers using Q-TOF LC/ MS; Andrey Giovanni Gomes de Oliveira ; Luciano Chaves Arantes ; Criminalistics Institute, Brazilian Federal District Civil Police (PCDF), Brasilia, Brazil WP 57 Forensic Applications of Probe Electrospray Ionization Mass Spectrometry (PESI-MS) using a Needle Coated with Polypyrrole; Carla S. de Freitas ; Ricardo Alves Bernardo ; Gessica Adriana Vasconcelos ; Veronica Vale Cavalho ; Thays Colletes Carvalho ; Wanderson Romão ; Andrea Chaves ; Boniek G Vaz ; Federal University of Goias, Goiania, GO; Federal University of Espirito Santo, Vitoria, Brazil WP 58 Rapid Detection of Drugs-of-abuse in Body Fluid by Mass Spectrometry; Tsz-Tsun Ng ; Pui-Kin So ; Bin Hu ; Zhong-Ping Yao ; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China WP 59 Classification of Synthetic Cathinones Using Neutral Mass Losses by Direct Analysis in Real Time Mass Spectrometry (DART-MS); Kristen Fowble ; Jason Shepard ; Rabi A. Musah ; University at Albany-SUNY, Albany, NY WP 60 Solid-phase Microextraction Combined with a Laminar Flow LC-MS/MS for High-Throughput and High Sensitive Analysis of Drugs in Oral Fluids; Vincent Bessonneau ; Janusz Pawliszyn ; University of Waterloo, Waterloo, Canada; University of Waterloo, Waterloo ON, Canada WP 6 Magnetic Graphene Framework as Adsorbent for the Enrichment of Flunitrazepam from Beverage Samples Prior to Its Determination by Mass Spectrometry; Qiuhua Wu ; Si Cheng ; Zhi Li ; Hao Chen ; Ohio University, Athens, OH; Ohio, Athens, OH WP 6 LC-MS/MS Analysis of Drugs of Abuse Using Biocompatible Solid Phase Micro Extraction; Sara Smith ; Emily Barrey ; Craig Aurand ; David Bell ; Candace Price ; MilliporeSigma, Bellefonte, PA WP 6 Evaluation of Solid Phase Micro Extraction Sample Preparation for LC-MS Analysis of Drugs in Urine and Plasma for Forensics; Marta Kozak ; Nathaly Reyes Garces ; German Augusto Gomez-Rios ; Cornelia Boeser 4 ; Sarracino David 4 ; Thermo Fisher Scientific, San Jose, CA; University of Waterloo, Waterloo, Ontario (ON); University of Waterloo, Waterloo ON, Canada; 4 ThermoFisher Scientific, San Jose, CA WP 64 The Development of a Two-Dimensional Liquid Chromatography-Tandem Mass Spectrometry Method for the Analysis of Designer Drugs in Urine; Holly Castellano; Duquesne University, Pittsburgh, PA WP 65 Drugs of Abuse Extraction from Whole Blood using Supported Liquid Extraction (SLE) Prior to GC/MS Analysis; Katie-Jo Teehan ; Rhys Jones ; Lee Williams ; Paul Roberts ; Helen Lodder ; Adam Senior ; Alan Edgington ; Geoff Davies ; Steve Jordan ; Claire Desbrow ; Victor Vandell ; Dan Menasco ; Biotage GB Limited, Cardiff, UK; Biotage GB Limited, Cardiff; Biotage LLC, Charlotte, NC WP 66 Illegal Drugs Analysis by Thermal Desorption and Pyrolysis Combined with Direct Analysis in Real Time- Mass Spectrometry (TDP/DART-MS); Hiroko Abe ; Chikako Takei ; Yasuo Shida ; Motoshi Sakakura 4 ; Teruhisa Shiota 4 ; Kayako Suga 5 ; Daisuke Yajima ; Hirotaro Iwase 6 ; University of Chiba, Chiba, Japan; BioChromato, Inc. Fujisawa, Japan; University of Yamanashi, Kofu, Japan; 4 AMR Inc., Meguro-Ku, Japan; 5 AB SCIEX, Tokyo, Japan; 6 University of Tokyo, Tokyo, Japan WP 67 Developement of an LC-MS/MS Screening Method for 0 Targeted Compounds in Whole Blood, Using Library Searching on a QTRAP MS; Heather Singletary ; Amanda Sweet ; Metro Nashville PD-Crime Lab, Madison, TN WP 68 Fast and Reliable Quantitation of Z-drug Hypnotics and Benzodiazepines in Serum using UHPLC-QTOF Mass Spectrometry; Sebastian Goetz ; Karin Wendt ; Tony Drury ; Matt Willetts ; Carsten Baessmann ; Bruker Daltonik GmbH, Bremen, Germany; Bruker Daltonics, Coventry, UK; Bruker Daltonic, Billerica, MA WP 69 Urine and Serum Ultra-Rapid Analysis of Flakka (alpha- PVP) in 9 Seconds per Sample by Laser Diode Thermal Desorption Mass Spectrometry ; Jonathan Rochon ; Annie-Claude Bolduc ; Réal Paquin ; Alex Birsan ; Serge Auger ; Jean Lacoursiere ; Pierre Picard ; Université Laval, Québec, Canada; Phytronix Technologies, Inc. Quebec, Canada WP 70 SWATH Data Used for Data Mining: What kind of Adulterants, Diluents and Other Toxic Compounds are Consumed Together with Cocaine?; Stefan König ; Thomas Wüthrich ; Marie Martin ; Werner Bernhard ; Wolfgang Weinmann ; Susanne Nussbaumer ; Institut für Rechtsmedizin, Universität Bern, Bern, Switzerland; Institut für Rechtsmedizin, Bern, Switzerland WP 7 Quantitative Multi Target Screening (MTS) using Liquid Chromatography-Tandem Mass Spectrometry with MS/ MS Library Based Identification for Forensic Toxicology; Alan Barnes ; Tiphaine Robin ; Simon Ashton ; Neil Loftus ; Pierre Marquet ; Sylvain Dulaurent ; Franck Saint-Marcoux ; Shimadzu, Manchester, UK; CHU Limoges, Limoges, France WP 7 Comprehensive and Sensitive Quantitation of More Than 00 Synthetic Cannabinoids in Serum by LC-MS/ MS; Laura M. Huppertz ; Rafaela Martin ; Markus Meyer ; Ronja Peter ; Juergen Kempf ; Institute of Forensic Medicine Freiburg, Freiburg, Germany; Bruker Daltonik PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

141 WEDNESDAY POSTERS GmbH, Bremen, Germany; Institute for Forensic Medicine Freiburg, Freiburg, Germany WP 7 Rapid Update of Screening Methods for the Detection of Synthetic Cannabinoid Use in Human Urine by Software Assisted Metabolite Identification; Bjoern Moosmann ; Laura M. Huppertz ; Florian Franz ; Sebastian Götz ; Volker Auwärter ; Institute of Forensic Medicine Freiburg, Freiburg, Germany; Bruker Daltonic GmbH, Bremen, Germany WP 74 Strategies for Classification and Annotation of Novel Synthetic Designer Drugs; Fanny Chu, ; A. Daniel Jones, ; Ruth Waddell Smith ; Forensic Science Program, School of Criminal Justice, Michigan State University, East Lansing, MI; Department of Chemistry, Michigan State University, East Lansing, MI; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI WP 75 Comprehensive Detection and Identification of Prescription Analgesics and Illicit Opioids in Post- Mortem Specimens using Ion Trap LC-MSn; Elisa N. Shoff ; George W. Hime ; Carsten Baessmann ; Diane M. Boland ; Miami Dade Medical Examiner Dept., Miami, FL; Bruker Daltonik GmbH, Bremen, Germany WP 76 CE-MS Analysis of Controlled Substances with Optical Isomer Resolution in about a Minute; Mehdi Moini ; Christopher Rollman ; George Washington University, Washington, DC WP 77 Screening Procedure to Detect Peptide Hormones Prohibited in Sports. CESI-MS vs LC-ESI-MS; Monica Mazzarino ; Xavier de la Torre ; Francesco Botrè ; Antidoping laboratory of Rome, Rome, Italy; Antidoping laboratory of Rome, FMSI Rome, Italy WP 78 Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry (HILIC-MS/MS) Method for the Quantitation of gamma-aminobutyric Acid (GABA) in Equine Plasma; Rong Yi ; Sarah Zhao ; Noel Kong ; Julia Zhang ; Devan Loganathan ; Sandrine Merette ; Barbara Morrissey ; MAXXAM, Burnaby, Canada GCMS: Instrumentation and Applications (Instrumentation-New Developments) 79-9 WP 79 Development of a Multi-Turn TOF Mass Spectrometer with a Cold Trap infitof-ct for Trace Gas Analysis; Hirofumi Nagao ; Shinichi Miki ; Ikunori Kannoh ; Michisato Toyoda ; MSI.TOKYO Inc, Chofu, Tokyo, Japan; Osaka University, Toyonaka, Osaka, Japan WP 80 GC-MS with Cold EI and Its Unexpected Benefits; Aviv Amirav ; Alexander B. Fialkov ; Tal Alon ; Uri Keshet ; Svetlana Tsizin ; Tel-Aviv University, Tel-Aviv; Tel Aviv University, Tel Aviv, Israel WP 8 Evaluation of Organometallic Compounds using GC/Q- TOF with a Novel High Efficiency Source; David Kaz ; Jennifer Sanderson ; Sofia Nieto ; Agilent Technologies, Santa Clara, CA WP 8 On-Line Coupling of Microscale Distillation with GC-MS for Analysis of Complex Samples; Ya-Ru Tang ; Pawel Lukasz Urban ; National Chiao Tung University, Hsinchu, Taiwan; Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan (R.O.C.) WP 8 Fast Analysis Workflow with No Sample Preparation for Forensic Applications using Open Probe FastGC/ MS: Unit and High Resolution Mass Spectrometers; Luis Cuadra-Rodriguez ; Jennifer Sanderson ; Bjorn Flatt ; Bill Russ ; Agilent Technologies, Santa Clara, CA WP 84 Vacuum Ultraviolet (VUV) Spectroscopy an Alternative to Mass Spectrometry for Gas Chromatography Detection; Changling Qiu ; Allegra Leghissa ; Jonathan Smuts ; Kevin A Schug ; University of Texas at Arlington, Arlington, TX; VUV Analytics, Inc., Cedar Park, TX WP 85 Gas Chromatography Electrospray Ionization Mass Spectrometry Analysis of Trimethylsilyl Derivatives; Ren-Yu Hsu ; Jhan-Hong Liao ; Hsin Wen Tien ; Guor-Rong Her ; National Taiwan University, Taipei, Taiwan WP 86 Characterization of lignans of Schisandra sphenanthera Fruit by Flash Evaporation-Gas Chromatography/ Mass Spectrometry; Huijun Liu ; Yilei Huang ; Zhongping Huang ; Yutian Chen ; Lili Wang ; Zhejiang University of Technology, Hangzhou, China WP 87 Interfacing Gas and Liquid Chromatography with High Temperature Plasma Mass Spectrometry; Sychyi Cheng ; Jentaie Shiea ; National Sun Yat- Sen University, Kaohsiung, Taiwan WP 88 EPA Method 5B, Novel Thermal Desorption Instrument Modification to Improve Sensitivity; Ronald Shomo ; John Manura ; Christopher W Baker ; Scientific Instrument Services, Ringoes, NJ WP 89 Trace Elemental Quantification of Carbon via the Production of Cyanide Anions in Plasma Assisted Reaction Chemical Ionization Mass Spectrometry (PARCI-MS); Peter Haferl ; Haopeng Wang ; Kaveh Jorabchi ; Georgetown University, Washington, DC WP 90 How We Can Improve Number of Compounds Found by Deconvolution in One Essential Oil Sample with GCMS?; Celso Blatt ; Romao Beserra ; Agilent Technologies Brasil Ltda, São Paulo, Sao Paulo WP 9 Raising the Identification Confidence in Non-Target Analysis of House Dust by Combining Classic and Soft Electron Ionization GC-HRMS; Peter Haglund ; Sofia Nieto ; Vadim Kalmeyer ; Nathan Eno ; Jennifer Sanderson ; Umea University, Umea; Agilent Technologies, Santa Clara, CA WP 9 GCxGC with Simultaneous Mass Spectrometry/ Flame Ionization Detection for Routine Petrochemical Analyses; Laura McGregor ; Nick P Bukowski ; Matthew Edwards ; Pete Grosshans ; Chris Hall ; Massimo Santoro ; Markes International, Cardiff, UK; Markes International Inc, Cincinnati, OH WP 9 A High Efficiency Ion Source for GC/MS; Jeffrey Kernan; Agilent Technologies, Santa Clara, CA Glycoproteins (Tandem MS, Separations, and Automation/Software) 94 - WP 94 Extending the Energy-resolved Collision-Induced Dissociation Method for Structural Characterization of Sialylated N-Glycopeptides; Venkata Kolli ; Katherine N Schumacher ; Eric D Dodds ; University of Nebraska - Lincoln, Lincoln, NE WP 95 Detailed Characterization of Glycans and Glycopeptides by Collisional and Electron Activated Dissociation; Kshitij Khatri ; Yi Pu ; Joshua Klein ; Cheng Lin ; Joseph Zaia ; Boston University, Boston, MA WP 96 Glycopeptide Analysis Using Parallel Data-Dependent Acquisition at Varied Normalized Collision Energies; Crystal Daniels ; Joseph Otto ; Jana Rocker ; Lindsay Schambeau ; Mitchell Cancer Institute, Mobile, AL WP 97 Sequential Chemical Charge Enhancement with Electron-Transfer Dissociation for the Site-Specific Characterization of Doubly Glycosylated Peptides; Yanyan Qu ; William R Alley ; Stephan Bach ; Wendell P Griffith ; Department of Chemistry, University of Texas at San Antonio, San Antonio, TX WP 98 Comparing Effectiveness and Specificity of Glycopeptide Enrichment Strategies for Qualitative LC-MS/MS Analysis of Depleted Human Plasma; Sarah Michelle Totten ; Majlinda Kullolli ; Christa Feasley ; Sharon J Pitteri ; Stanford University School of Medicine, Palo Alto, 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 4

142 GENERAL WEDNESDAY INFORMATION POSTERS CA; Stanford University School of Medicine, Palo Alto CA; Thermo Fisher Scientific, West Palm Beach, FL WP 99 Online Cotton HILIC: An Easily Accessible and Affordable Enrichment of Glycopeptides; Jingfu Zhao ; Ehwang Song ; Yehia Mechref ; Texas Tech University, Lubbock, Texas WP 00 Affinity-capture Based Methods for N-glycan Analysis of Specific Serum Proteins; Gunnar Thorsén ; Alessandro Quaranta ; Isabella Karlsson ; Anna Sroka-Bartnicka ; Matthijs Pijnappel ; Lorena Ndreu ; Stockholm University, Stockholm, Stockholm; Department of Environmental Science and Analytical Chemistry, Stockholm University, Stockholm, SE WP 0 Separation and Detection of PSA-derived Sialic Acid Attachment Isomers Using a Heated PGC Column and LC-MS/MS; Yifan Huang ; Shiyue Zhou ; Yehia Mechref ; Texas Tech University, Lubbock, TX WP 0 N-glycosylation Analysis of Specific Serum Proteins using an Automated Microfluidic Platform and MALDI- MS; Alessandro Quaranta ; Anna Sroka-Bartnicka ; Isabella Karlsson ; Lorena Ndreu ; Matthijs Pijnappel ; Thorsén Gunnar ; Stockholm University, Stockholm WP 0 Identification and Separation of N-glycans by HILIC/MS; Zsuzsanna Lakos ; Elena Dremina ; Robert Carney ; John L. Snyder ; Eurofins Lancaster Laboratories, Lancaster, PA WP 04 Silk-Based Glyco-Enrichment Tip for Purification and Enrichment of Glycans and Glycopeptides; Haci Mehmet Kayili, ; Mehmet Atakay ; Bekir Salih ; Hacettepe University, Department of Chemistry, Ankara, Turkey; Çankırı Karatekin University, Department of Chemistry, Çankırı, Turkey WP 05 N-linked Glycosylation Analysis of Seasonal Influenza Vaccine Hemagglutinins; Yanming An ; Lisa Parsons ; John Cipollo ; FDA/CBER, Silver Spring, MD WP 06 Assisting the Identification of Isomeric Glycoforms with a Hydrophilic Interaction Liquid Chromatography Retention Time Model for Procainamide Tagged N-linked Glycans; Emily Betchy ; Barry Boyes ; Ron Orlando ; CCRC, University of Georgia Athens, GA; Advanced Materials Technology, Wilmington, DE WP 07 Glycopeptidomics with Ion Mobility Spectrometry for Elucidating Glycan Structures; Miklos Guttman ; Kelly Lee ; University of Washington, Seattle, WA WP 08 Automated Processing of LC-MSMS Data for Quantitative Analysis of the Human-like N-glycosylation of Glycoproteins Produced by a Glyco-optimization Cell Platform; Robert Wilmanowski ; Catherine Evans ; Anja Resemann ; Peter Hufnagel ; Rainer Paape ; Detlev Suckau ; Wolfgang Jabs ; Sven Bahrke ; Keven Lothert ; Andrea Hahne ; Glycotope GmbH, Berlin, Germany; Bruker Ltd, Coventry, UK; Bruker Daltonic GmbH, Bremen, Germany WP 09 N-glycan Analysis using GIG-automation on Sialylglycotransferase Knock-in CHO Cell Line; Shuang Yang ; Qiong Wang ; Lijun Chen ; Bojiao Yin ; Li Shuwei 4 ; Michael Betenbaugh ; Hui Zhang ; John Hopinks Dept. of Pathology, Baltimore, MD; Johns Hopkins University, Baltimore, MD; Johns Hopkins School of Medicine, Baltimore, MD; 4 University of Maryland, College Park, MD WP 0 GPQuest: A Free Software for Identification of Glycans and Intact Glycopeptides; Yingwei Hu ; Shadi Toghi Eshghi ; Weiming Yang ; Punit Shah ; Shisheng Sun ; Shuang Yang ; Lingquan Deng ; Xingde Li ; Hui Zhang ; Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD; Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD WP Scalable Computational Tool for Identifying Intact Glycopeptides in Complex Samples Using Mass Spectrometry; Lei Wang ; Chuan-Yih Yu ; Anoop M Mayampurath ; Rui Zhu ; Ehwang Song ; Yehia Mechref ; Haixu Tang ; Indiana University, Bloomington, IN; University of Chicago, Chicago, IL; Texas Tech University, Lubbock, Texas WP GLYMPS: A Tool to Automatically Assign Glycopeptides from MSEdata; Lisa Parsons ; Yanming An ; John F Cipollo ; FDA/CBER, Silver Spring, MD WP Confident, Automated N-glycoproteomics Profiling in Unenriched and Glycopeptide-Enriched Cancer Cell Samples; Shadab Ahmad ; Amol Prakash ; Sergei I Snovida ; Scott M Peterman ; Chu-Wei Kuo 4 ; Kay-Hooi Khoo 4 ; Gauri Muradia 5 ; Jeremy P Kunkel 5 ; Jessie R Lavoie 5 ; Nina Soltero ; Julian A Saba ; Optys Tech Corporation, Brighton, MA; Thermo Fisher Scientific, San Jose, CA; Thermo Scientific BRIMS, Cambridge, MA; 4 Academia Sinica, Taipei, Taiwan; 5 Health Canada, Ottawa, Canada H/D Exchange: Hardware, Software and Methodology 4-7 WP 4 The Development of a Fully Customized HDX-MS Platform with Exceptional Performance on Back- Exchange, Robustness and Reproducibility; Chengjie Ji ; Jeff Zhu ; Qian Li ; Yankun Li ; Novabioassays LLC, Woburn, MA WP 5 MALDI Compatible Protease Chips - A Novel Platform For Protein H/D Exchange; Michal Rosulek, ; Petra Darebna, ; Daniel Kavan, ; Petr Man, ; Michael Volny ; Petr Pompach, ; Petr Novak, ; Institute of Microbiology CAS, Prague, Czech Republic; Faculty of Science, Charles University in Prague, Prague, Czech Republic; AffiPro, s.r.o, Mratin, Czech Republic WP 6 Protease Type XVIII Columns for Enhanced Digestion Efficiency and Sequence Resolution for Protein HDX Monitored by Q Exactive MS; Chengjie Ji ; Qian Li ; Yankun Li ; Novabioassays LLC, Woburn, MA WP 7 Improvements to HDX Workbench Software for Analysis and Interpretation of HDX MS Data; Bruce D. Pascal ; Venkatasubramanian Dharmarajan ; Scott Novick ; Jie Zheng ; Vinh Lam ; The Scripps Research Institute, Jupiter, Florida WP 8 In-source Column Cooling for nanohx-ms on Complex Druggable Protein Scaffolds; Joey Sheff ; David Schriemer ; University of Calgary, Calgary, Canada WP 9 Post-column Hydrogen-deuterium Exchange Method for the Identification of Organic Compounds; Emmanuel Eysseric ; Xavier Bellerose ; Jean-Michel Lavoie ; Pedro A Segura ; Université de Sherbrooke, Sherbrooke, QC WP 0 How Precise are HDX-MS Measurements? Results from the NIST HDX-MS Interlaboratory Comparison Project; Jeffrey W. Hudgens, ; Elyssia S Gallagher, ; Ioannis Karageorgos, ; National Institute of Standards and Technology, Rockville, MD; Institute for Bioscience and Biotechnology Research, Rockville, MD WP Phosphoform-Specific Characterization of Protein Conformational Changes Induced by Multisite Phosphorylation; Jingxi Pan ; Albert Chou ; Suping Zhang ; Christoph H. Borchers, ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; MRM Proteomics Inc, Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada WP Top-Down Analysis of On-the-Fly HDX of NativeProtein Ions; Ken Chanthamontri ; Nawaporn Sanguantrakun, ; Michael L Gross ; Washington University in St Louis, St Louis, MO; Saint Louis College of Pharmacy, St. Louis, MO; Washington University in St. Louis, Saint Louis, MO PAGE 4 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

143 WEDNESDAY POSTERS WP HDXMS Studies of Membrane Proteins (GPCR) Expressed in Virus like Particles (VLP); Deepa Balasubramaniam ; Carrie A Shipley ; Beata A Zamlynny ; Margarita Garcia-Calvo ; Payal Sheth ; Michael Kavana ; David G McLaren ; Merck Research Labs, Kenilworth, NJ WP 4 HX-MS Reveals a Loss of Helical Structure in an Intrinsically Disordered Protein under Highly Crowded Conditions; Farai Rusinga; University of Kansas, Lawrence, KS WP 5 Observation of H/D Exchange at Non-labile C-H Sites Capable by an Increase in Desolvation Temperature in ESI-source; Alexander Zherebker, ; Yury Kostyukevich,,4 ; Alexey S Kononikhin, 4 ; Vitaliy Roznyatovsky ; Igor A Popov 4, 5 ; Yuri K. Grishin ; Irina V Perminova ; Eugene Nikolaev ; Lomonosov Moscow State University, Moscow, Russia; Institute for Energy Problems of Chemical Physics, Moscow, Russia; Skolkovo Institute of Technology, Moscow, Russia; 4 Moscow Institute of Physics and Technology, Moscow, Russia; 5 Emanuel Institute of Biochemical Physics, Moscow, Russia WP 6 Towards a High Throughput Binding-Site Specific Drug Screening by HDX MS; ROMAN ZUBAREV ; Juan Astorga-Wells,, 4 ; Thorleif Lavold ; Karolinska Institutet, Stockholm, Sweden; Karolinska Institutet, Solna, Sweden; Biomotif AB, Stockholm, Sweden; 4 HDXperts AB, Stockholm, Sweden WP 7 Negative Ion Electron Capture Dissociation (niecd) of Deuterated Peptides; Qingyi Wang ; Kristina Håkansson ; University of Michigan Department of Chemistry, Ann Arbor, MI H/D Exchange: Protein Structure/Function (Part ) 8-6 WP 8 Utilizing Hydrogen Exchange Mass Spectrometry to Interrogate KRas Binding to SOS at Two Distinct Sites; Rane A Harrison ; Andreas Zoephel ; Klaus Rumpel ; John R Engen ; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA; Department of Medicinal Chemistry, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; Department of New Therapeutic Concept Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria WP 9 Local Dynamics in Lipid-Associated Apolipoprotein A-I and Effects of Disease-Causing Mutations Probed by Hydrogen-Deuterium Exchange MS; Christopher Jay Wilson ; Madhurima Das ; Xiaohu Mei ; John R Engen ; Olga Gursky ; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA; Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA WP 0 Integrating XL-MS and HX-MS Data to Develop a Model of DNA Binding to DNAPKcs; Morgan Hepburn ; Daniel Saltzberg ; Yapping Yu ; Susan Lees-Miller ; Andrej Sali ; David Schriemer ; University of Calgary, Calgary, Canada; University of California, San Francisco, CA WP Identification of a Structural Conduit for Thermal Energy Transfer from Solvent to Enzyme Active Site using Hydrogen/Deuterium Exchange Mass Spectrometry; Anthony T Iavarone ; Adam R Offenbacher ; Judith P Klinman ; UC Berkeley, Berkeley, CA WP Examining the Importance of Conformational Dynamics for the Function of Pyruvate Kinase: Insights from HDX- MS; Courtney S Fast ; Siavash Vahidi ; Stanley D Dunn ; Lars Konermann ; Western University, London, Canada WP Analysis of HIV Nef Dimerization and Binding Partner Interactions by Hydrogen Exchange Mass Spectrometry; Jamie Moroco ; John Jeff Alvarado ; Thomas E Smithgall ; John R Engen ; Northeastern University, Boston, MA; University of Pittsburgh School of Medicine, Pittsburgh, PA WP 4 Pre-Amyloid Oligomer Dissociation Kinetics Studied by Hydrogen/Deuterium Exchange Mass Spectrometry; Zhe Zhang ; Richard W Vachet ; University of Massachusetts Amherst, Amherst, MA WP 5 Gas-Phase H/D Exchange Monitored by MS Reveals a Dense Network of Side-Chain Interactions Stabilizing Oligomers of Alzheimer s Disease Aβ Peptide; Kaja Przygonska ; Kinga Fituch ; Ewa Sitkiewicz ; Kasper D Rand ; Michal Dadlez ; Institute of Biochemistry and Biophysics, Polish Academy of Science, Warsaw, Poland; Department of Pharmacy, University of Copenhagen Copenhagen, Denmark WP 6 Effect of Protein Structure on Antibody Deamidation Rates: A Combination of Peptide Mapping, D Modeling, and Hydrogen/Deuterium Exchange Mass Spectrometry; Paul Mawson; Ridgefield, CT ICP and Isotope Ratio MS: Elemental 7-4 WP 7 Measurement of the Molar Mass of 8Si-enriched Silicon Crystal with High Resolution Inductively Coupled Plasma Mass Spectrometer; Tongxiang Ren ; Jun Wang ; Tao Zhou ; Hai Lu ; National Institute of Metrology, Beijing, Chaoyang; National Institute of Metrology, Beijing, China WP 8 Selenium Accumulation and Speciation in Supplemented Aquaponic Systems Using Reverse Phase HPLC and ICP-QQQ; Skyler Smith ; Julio A. Landero-Figueroa ; Megan Schmale ; University of Cincinnati, Cincinnati, OH WP 9 Environmental Source Determination Using Stable Lead Isotope Ratios in American Woodcock (Scolopax minor) Feathers and Bone; Amanda D. French ; Warren C Conway ; Daniel S Sullins ; David Klein ; Texas Tech University, Lubbock, Texas; Kansas State University, Manhattan, KS; Texas Tech University, Lubbock, TX WP 40 Rapid Determination of Calcium in Water by Spray Microwave Plasma Torch Mass Spectrometry; Meiling Yang ; Xinchen Wang ; Tao Zhong ; Huanwen Chen ; East China Institute of Technology, Nanchang, China; East China University of Technology, Nanchang, Mainland WP 4 Determination of Absolute Isotopic Composition of Mo by MC-ICP-MS using Synthetic Isotope Mixtures and Uncertainty Evaluation; Panshu Song ; Jun Wang ; National Institute of Metrology, Beijing, China Imaging MS: Method Development (DESI/SIMS/Misc) 4-64 WP 4 A Novel Quantitative Imaging Strategy of Elements in Biological Tissue by Isotope Dilution Laser Ablation ICP-MS; Liuxing Feng; National Metrology Institute, China, Beijing, Beijing WP 4 Differential Protein Profiling using Virtual D Gel-Mass Spectrometry; Neil R Quebbemann ; Joseph A Loo ; Rachel R. Ogorzalek Loo ; University of California, Los Angeles, Los Angeles, CA WP 44 Targeted DESI Mass Spectrometry Imaging in Ovarian Cancer; Luisa Doria ; James McKenzie ; Anna Mroz ; Abigail Speller ; Francesca Rosini ; David Phelps ; Emrys A Jones ; Renata Soares ; Kirill Veselkov ; Sadaf Ghaem- Maghami ; Zoltan Takats ; Imperial College, London, UK; Waters, Manchester, UK WP 45 Tissue Imaging with Specificity for Unsaturated Lipid Isomers Using Mass Spectrometry with Photochemical Reactions; Chengan Guo ; Xiaoxiao Ma ; Yuan Su ; Ran Tian ; Ruyi Shi ; Fei Tang ; Yu Xia ; Zheng Ouyang ; Tsinghua University, Beijing, China; Purdue University, West Lafayette, IN 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 4

144 GENERAL WEDNESDAY INFORMATION POSTERS WP 46 Methodology for Drug Delivery Quantitation in Single Cells using TOF-SIMS; Anthony Castellanos ; Quentin Vanbellingen ; Francisco Fernandez-Lima, ; Florida International University, Miami, FL; Biomolecular Science Institute, Miami, FL WP 47 Single Cell Analysis using nano-desi Mass Spectrometry; Hilde-Marléne Bergman ; Ingela Lanekoff ; Uppsala University, Uppsala, Sweden WP 48 Region- and Enzyme-Specific Bioconversion of Dynorphin Neuropeptide Detected by in situ Histochemistry and MALDI Imaging Mass Spectrometry.; Erik Bivehed ; Stromvall Robert ; Malin Andersson ; Uppsala University, Uppsala, Sweden WP 49 Combining SRS Microscopy and MS Imaging; Elizabeth C. Randall, ; Alasdair Rae ; Alan M. Race ; Helen J. Cooper ; Josephine Bunch ; University of Birmingham, Birmingham, UK; National Physical Laboratory, Teddington, UK WP 50 Tissue Classification using Mass Spectrometry and Membrane Microarrays; Jone Garate ; Roberto Fernandez ; Tarson Tolentino-Cortez ; Sergio Lage ; Gabriel Barreda-Gómez ; Egoitz Astigarraga ; Jose A Fernandez ; University of Basque Country, UPV/EHU Leioa Basque Country, Spain; IMG Pharma Biotech, Zamudio, Spain WP 5 Ambient Ionization Mass Spectrometry for Preoperative Diagnosis of Indeterminate Thyroid Nodules; Jialing Zhang ; Wendong Yu ; Clara L Feider ; Jerry Buentello ; Robert Tibshirani 4 ; James W Suliburk ; Livia S Eberlin ; UT Austin, Austin, TX; Baylor College of Medicine, Houston, TX; University of Texas at Austin, Austin, TX; 4 Stanford University, Stanford, CA WP 5 Mass Spectrometry Imaging of the Human Pancreas Lipidome; Grant Barry ; Daniel Cavazos ; Igor Veryovkin ; Manami Hara ; Graeme Bell ; Luke Hanley ; University of Illinois at Chicago, Chicago, IL; University of Chicago, Chicago, IL WP 5 Simultaneous Detection and Imaging of Drugs and Delivery Vehicles using LDI-MS; Bo Zhao ; Mine Canakci ; Sankaran Thayumanavan ; Richard W Vachet ; University of Massachusetts Amherst, Amherst, MA WP 54 Polarity Switching and Quantitative Mass Spectrometry Imaging of Healthy and Cancerous Hen Ovarian Tissue Sections using IR-MALDESI; Milad Nazari ; Mark T Bokhart ; Kenneth P Garrard ; David C Muddiman ; North Carolina State University, Raleigh, NC WP 55 Rapid Detection and Imaging of Fire-Retardant- Cyclodextrin-Inclusion Complexes on fibers and films by using IR-MALDESI Mass Spectrometry; Yufei Chen ; Nanshan Zhang ; Milad Nazari ; Mark Bokhart ; Maans Ekeloef ; David C Muddiman ; Nelson R Vinueza ; North Carolina State University, Raleigh, NC WP 56 Metabolomic Imaging of Biofilm and Other Biological Materials for Studying Metabolomic Heterogeneity; Tomasz Ruman ; Joanna Nizioł ; Vincent Bonifay ; Jon Brauer ; Christine Gaylarde ; Iwona B Beech ; Jan A Sunner ; University of Oklahoma, Norman, OK WP 57 Matrix-free Analysis of Resveratrol in Intact Rat Retina Tissue Using REDIchip; Amanda Martinez ; Andrea Kelley ; Madeline Colley ; Stephan Bach ; University of Texas at San Antonio, San Antonio, TX WP 58 Lanthanide Labeled Antibody Detection by SIMS nano-tof II of Human Intestinal Injury Markers; Keely Pierzchalski; Maastricht, Limburg WP 59 Mass Spectrometric and FT-IR Spectroscopic Imaging to Probe Organic Ligands and Their Binding Schemes on Nanocrystals; Tae Lee ; Jin Gyeong Son ; Jeong Hee Moon ; Sang Woo Han ; KRISS, Daejeon; KAIST, Daejeon, Republic of Korea; KRIBB, Daejeon, Republic of Korea WP 60 Analysis of Medical Devices in D and D by Secondary Ion Mass Spectrometry; Adam Taylor ; Felicia Green ; Bonnie Tyler ; Josephine Bunch ; National Physical Laboratory, Teddington, UK WP 6 Multiplex Proteins and Lipids SIMS Imaging of Mouse Hippocampus Tissues; Eunseok Seo ; Sun young Lee ; Young-ho Park ; EunSook Choi ; Eunjoo Kim ; Dong Kwon Lim ; Su-Il In ; DaeWon Moon ; DGIST, Daegu, Korea; Korea University, Seoul, Korea WP 6 Imaging Mass Spectrometry as a Novel Approach to Measure Synaptic Zinc; Masoumeh Dowlatshahi Pour, ; Lin Ren ; Andrew G Ewing, ; Per Malmberg, ; Chalmers University of Technology, Gothenburg, Sweden; National Center for Imaging Mass Spectrometry, Gothenberg, Sweden WP 6 Precursor Ion Selector Scan for Discovery of Analyte Specific Fragments in MALDI-TOF/TOF-MS/MS; Stanislav Rubakhin ; Jonathan V Sweedler ; Beckman Institute, UIUC, Urbana, IL; University of Illinois at Urbana- Champaign, Urbana, IL WP 64 MS Imaging to Analyse the Transition from Early Goal-Directed Phase to Late Habituation Phase of Spatial Learning in Mice; Geert Baggerman, ; Jeroen Aerts ; Laurens Minerva ; Dirk Valkenborg,, 4 ; Annelies Laeremans ; D hooge Rudi ; Kurt Boonen ; Lutgarde Arckens ; Flemish Institute for Technological Research (VITO), Mol, Belgium; University of Antwerp, Antwerp, Belgium; KU Leuven, Leuven, Belgium; 4 Hasselt University, Diepenbeek, Belgium Informatics: Algorithms and Statistical Advances WP 65 A Processing Pipeline for Dramatically Increased Statistical Power in Label-Free Quantitative Proteomics; Michael J Sweredoski ; Annie Moradian ; Tanya R Porras- Yakushi ; Sonja Hess ; Caltech, Pasadena, CA WP 66 Missing Value Prediction in Metabolite-Intensity Matrix of a Quantitative Metabolomic Dataset Generated by Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry; Yunong Li ; Tao Huan ; Liang Li ; University of Alberta, Edmonton, Canada WP 67 Improved Qualitative and Quantitative Analysis of the Human Mitochondrial Proteome by Hybrid Acquisition; Maurizio Ronci ; Enrico Cilio ; Steven Ciavarini ; Curt Devlin ; Brad Williams ; Scott Geromanos ; Chris Hughes ; Johannes Vissers 4 ; Andrea Urbani ; University of Rome Tor Vergata, Rome, Italy; Waters, Milford, MA; Waters, Wilmslow, UK; 4 Waters Corporation, Wilmslow, Greater Manchester WP 68 Development of MSn Spectral Database and the Search Algorithm using Multiple MSn Spectra; Yohei Yamada ; Akemi Suzuki ; Umemura Yoshikatsu ; Hiroyuki Yasuda ; Yutaro Yamamura ; Hideshi Fujiwake ; Kageyama Tetsuya ; Shimadzu Corporation, Kyoto, Japan; Tohoku Pharmaceutical University, Miyagi, Japan WP 69 Analysis of Polarity-Switched DESI Images of Colorectal Tissue Samples; James Stuart McKenzie ; Anna K Mróz ; Renata Filipe-Soares ; Zoltan Takats ; Imperial College, London, UK WP 70 Mass Graph-Based Proteoform Identification by Top-Down Mass Spectrometry; Qiang Kou ; Si Wu ; Nikola Tolic ; Ljiljana Pasa-Tolic ; Xiaowen Liu 4, 5 ; Indiana University-Purdue University, Indianapolis, IN; University of Oklahoma, Dept. of Chem & Biochem Norman, OK; Pacific Northwest National Laboratory, Richland, WA; 4 Indiana University-Purdue University Indianapolis, Indianapolis, IN; 5 Indiana University School of Medicine, Indianapolis, IN PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

145 WEDNESDAY POSTERS WP 7 A Very Fast Bayesian Engine for Truly unified MS- and MS-based Protein Inference; Julianus Pfeuffer ; Xiao Liang ; Knut Reinert ; Oliver Kohlbacher ; Oliver Serang ; Eberhard Karls Universität Tübingen, Tübingen, BW, Deutschland; Freie Universität Berlin, Berlin, Germany; Freie Universität Berlin, Berlin WP 7 An Adjusted-Median Approach to Missing Values in Label Free Quantitation; Seth Just ; Luisa Zini ; Nick Vincent-Maloney ; Brian C Searle, ; Proteome Software, Portland, OR; University of Washington, Seattle, WA WP 7 Machine Learning Algorithms for Advanced Identification of Tumor Tissue and Tumor Borders; Evgeny Zhvansky, ; Igor A Popov, ; Anatoly Sorokin ; Nikita Levin ; Vsevolod Shurkhay ; Denis Bormotov ; Maria Indeykina, 4 ; Alexey S Kononikhin, 4 ; Yury Kostyukevich, 4 ; Evgeny Kukaev, ; Alexander Potapov ; Eugene Nikolaev ; Moscow Institute of Physics and Technology, Moscow, Russia; Institute for Energy Problems of Chemical Physics, Moscow, Russia; Burdenko Neurosurgical Institute, Moscow, Russian Federation; 4 Emanuel Institute of Biochemical Physics, Moscow, Russia WP 74 Making the Most of Multi-Modality Imaging: Exploring Fusion of Mass Spectrometry Imaging with Stimulated Raman Spectroscopy; Alan Race ; Alasdair Rae ; Jean- Luc Vorng ; Rory Steven ; Josephine Bunch ; Ian Gilmore ; National Physical Laboratory, Teddington, Middlesex; National Physical Laboratory, Teddington, UK WP 75 Automated Tumor Typing of Tissue Sections Based on Characteristic Spectral Patterns Extracted from MALDI Mass Spectrometry Imaging Data; Tobias Boskamp, ; Delf Lachmund ; Nicolas Jathe ; Christian Etmann ; Janina Oetjen ; Rita Casadonte ; Jan Hendrik Kobarg ; Dennis Trede ; Jörg Kriegsmann, 4 ; Peter Maass, ; University of Bremen, Bremen, Germany; SCiLS GmbH, Bremen, Germany; Proteopath GmbH, Trier, Germany; 4 Center for Histology, Cytology and Molecular Diagnostic, Trier, Germany WP 76 Virtual Lock Masses: An Algorithmic Method to Enable Mass Spectra Comparison in Untargeted Studies; Francis Brochu ; Pier-Luc Plante, ; Alexandre Drouin ; Louis-Émile Robitaille ; François Laviolette ; Mario Marchand ; Jacques Corbeil, ; Université Laval, Québec, Canada; Centre de Recherche du CHU de Québec, Québec, Canada WP 77 Isotopic Tree: Fast Calculation of Fine and Coarse Isotopic Envelopes up to a Predefined Margin of Error; Dmitry Avtonomov ; Alexey I Nesvizhskii ; University of Michigan, Ann Arbor, MI WP 78 DISCO - Data Independent Signal Correlator; David Shteynberg ; Samuel L Bader ; Andrew Keller ; Michael Hoopmann ; Luis Mendoza ; Eric Deutsch ; Robert L Moritz ; Institute for Systems Biology, Seattle, WA WP 79 A Parameterized Averagine Model Improves Feature Detection of Oligonucleotides and Increases Wider Applicability of Feature Finding Algorithm; Samuel Wein ; Benjamin A Garcia ; University of Pennsylvania, Philadelphia, Pa; University of Pennsylvania, Philadelphia, PA WP 80 MassTodon - Electron Transfer driven Fragmentation Analyzer and Automatic Spectrum Calibrator; Mateusz Krzysztof Łącki, ; Frederik Lermyte, 4 ; Michał Startek ; Dirk Valkenborg 4, 5, 6 ; Frank Sobott, 4 ; Anna Gambin ; University of Warsaw, Warszawa, Mazowieckie; Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Warsaw, Poland; Biomolecular & Analytical Mass Spectrometry group, University of Antwerp, Antwerpen, Belgium; 4 UA-VITO Center for Proteomics, University of Antwerp, Antwerpen, Belgium; 5 Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Hasselt, Belgium; 6 VITO, Mol, Belgium WP 8 IsoSpec - a Hyperfast Generator of Fine Isotopic Structure Peaks with Preset Total Probability; Mateusz Krzysztof Łącki ; Michał Startek ; Dirk Valkenborg,, 4 ; Anna Gambin ; Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Warsaw, Poland; UA-VITO Center for Proteomics, University of Antwerp, Antwerpen, Belgium; Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Hasselt, Belgium; 4 VITO, Mol, Belgium WP 8 Robust Algorithms for Denoising, Eliminating Dispersion Similar to Phasing in D_FT-MS Spectra and Reconstructing Non Uniformly Sampled D_FT-ICR Data; Lionel Chiron ; Fabrice Bray ; Christian Rolando ; Marc-André Delsuc 4 ; CASC4DE, Strasbourg, France; Université de Lille, Villeneuve d Ascq, France; Univ. de Lille, Sciences et Technologies, Villeneuve d Ascq; 4 Université de Strasbourg, Strasbourg, France WP 8 Finding the Peaks: Performance Enhancement of Portable MS using a Bayesian Approach; Simon Maher ; Simon Maskell ; Sarfaraz Syed ; Fred Jjunju ; Stephen Taylor ; Department of Electrical Engineering and Electronics University Of Liverpool, Liverpool, UK; Maastricht University, Maastricht, NL WP 84 Integrated GlycoProteome Analyzer (I-GPA) for Automatic Identification and Quantitation of Site- Specific N-Glycosylation; Gun Wook Park, ; Jin Young Kim ; Heeyoun Hwang ; Ju Yeon Lee ; Young Hee Ahn ; Hyun Kyoung Lee ; Eun Sun Ji ; Hoi Keun Jeong ; Ki Na Yun ; Yong-Sam Kim 4 ; Jeong-Heon Ko 4 ; Hyun Joo An 5 ; Jae Han Kim 5 ; Young-Ki Paik 6 ; Jong Shin Yoo ; Chungnam National University, Cheongju, Chungbuk; Korea Basic Science Institute, Cheongju-Si, Republic of Korea; Cheongju University, Cheongju-Si, Republic of Korea; 4 Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; 5 Chungnam National University, Daejeon, Republic of Korea; 6 Yonsei University, Seoul, South Korea WP 85 Identification of N-glycopeptides using Open Spectral Library Search; Zhiwu An ; Qingbo Shu ; Hao Lv ; Jianjun Yu ; Fuquan Yang ; Yan Fu ; Chinese Academy of Sciences, Beijing, Beijing WP 86 Extending MS Interpreter: A Freely-Available Tool for Structure/Spectrum Self-Consistency of High Resolution Tandem Mass Spectra; Alexey V. Mayorov, ; Yuri Mirokhin ; Dmitrii Tchekhovskoi ; Stephen Stein ; NIST, Gaithersburg; N.M. Emanuel Institute of Biochemical Physics RAS (IBCP RAS), Moscow, Russian Federation; NIST, Gaithersburg MD WP 87 Machine Learning-Driven Validation Platform for Mass Spectrometry Imaging using Tandem Mass Spectra and Chemical Structure Databases; Ivan Laponogov ; Emilie J L Cauet ; James McKenzie ; Robert C Glen ; Zoltan Takats ; Kirill Veselkov ; Imperial College London, London, London; Imperial College, London, UK WP 88 Improving LC-MS Coverage through New Charge State and Monoisotopic m/z Assignment Algorithms; Graeme McAlister ; Derek Bailey ; Romain Huguet ; Michael Senko ; Thermo Fisher Scientific, San Jose, CA WP 89 SAINTq: Robust Scoring of Protein-Protein Interactions in Quantitative AP-SWATH Experiments; Guoci Teo ; Hiromi WL Koh ; Damian Fermin ; Jean-Philippe Lambert ; James Knight ; Anne-Claude Gingras ; Hyungwon Choi 4 ; National University of Singapore, Singapore, Singapore; Yale University, New Haven, CT; Lunenfeld Tanenbaum Research Institute, Toronto, Canada; 4 National University of Singapore, Singapore 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 45

146 GENERAL WEDNESDAY INFORMATION POSTERS Informatics: Workflow and Data Management WP 90 Galaxy-P: Recent Developments and Emerging Applications; Pratik Jagtap, ; James Johnson ; Thomas McGowan ; Innocent Onsongo ; Benjamin Lynch ; Candace Guerrero ; Kevin Murray ; Lloyd M Smith 4 ; Michael R Shortreed 4 ; Anthony J Cesnik 4 ; Lennart Martens 5, 6 ; Adrian Hegeman ; Timothy Griffin, ; University of Minnesota, Minneapolis, MN; Center for Mass Spectrometry and Proteomics, UMN St.Paul, MN; University of Minnesota Supercomputing Institute, Minneapolis, MN; 4 University of Wisconsin Madison, Madison, Wisconsin; 5 Ghent University, Ghent, Belgium; 6 VIB, Ghent, Belgium WP 9 Optide-Hunter: Informatics Solutions for Optimized Peptide Drug Development through the Integration of Heterogeneous Data and Adaptation of Various LC-MS Technologies; Mi-Youn Brusniak ; Emily Girard ; Bernard Lee ; Chris Mehlin ; Yuko Ogata ; Philip Gafken ; Hector Ramos ; Jim Olson ; Fred Hutchinson Cancer Research Center, Seattle, WA; LabKey Software, Seattle, WA WP 9 APOSTL: An interactive Galaxy Pipeline For Reproducible Analysis of Affinity Proteomics Data; Brent Kuenzi ; Adam Borne ; Jiannong Li ; Uwe Rix ; Paul Stewart ; Eric Haura ; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL WP 9 Enabling Collaborative Discovery in Big Data Visual Analytics; Joon-Yong Lee ; Ryan Wilson ; Grant M Fujimoto ; Gary R Kiebel ; Richard D Smith ; Nick Cramer ; Samuel H Payne ; Pacific Northwest National Lab, Richland, WA WP 94 Scientific Workflows for Data Analysis and Visualization in Quantitative Proteomics; Arzu Tugce Guler ; Dmitrii Travin ; Yassene Mohammed ; Magnus Palmblad ; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, Netherlands; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia WP 95 Integration of Peptide-Centric Searching of Data Independent Acquisition Data without an MS/MS Spectrum Library with Data in the Chorus Project; Michael J. MacCoss ; Brian C Searle ; Sonia Ying Ting ; Jarrett Egertson ; Christine C Wu ; Andrii Laboda ; Oleksii Tymchenko ; Andrey Bondarenko ; Univ of Washington, Seattle, WA; Stratus Biosciences, Seattle, WA; Infoclinika, LLC, Seattle, WA WP 96 High Performance Computing at the National Resource for Translational and Developmental Proteomics; Ryan T Fellers ; Richard D LeDuc ; Bryan P Early ; Joseph B Greer ; Alexandra J Van Nispen ; Paul M Thomas ; Neil L Kelleher ; Northwestern University, Evanston, IL WP 97 The MassIVE Repository for Interactive Annotation of Proteomics Big Data; Jeremy Carver ; Mingxun Wang ; Nuno Bandeira ; UCSD, La Jolla, CA WP 98 The Potential of Functional Annotation of Mass Spectrometry Tools; Magnus Palmblad ; Arzu Tugce Guler ; Kristian Davidsen ; Jon Ison ; Veit Schwämmle ; Leiden University Medical Center, Leiden, the Netherlands; Technical University of Denmark, Copenhagen, Denmark; University of Southern Denmark, Odense, Denmark WP 99 Recent Developments in ProteomicsDB: From FDR Estimates to Proteomic Assays and More; Mathias Wilhelm ; Daniel Paul Zolg ; Hans-Christian Ehrlich ; Stephan Aiche ; Mohammed AbuJarour ; David Weese ; Judith Schlegl ; Tobias Schmidt ; Wilhelm Becker ; Lars Rückert ; Jan Huenges ; Susan Klaeger, 4, 5 ; Stephanie Heinzlmeir, 4, 5 ; Hannes Hahne, 6 ; Bernhard Kuster, 4, 5 ; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany; Innovation Center Potsdam, SAP SE, Potsdam, Germany; SAP SE, Walldorf, Germany; 4 German Cancer Consortium (DKTK), Muenchen, Germany; 5 German Cancer Research Center, Heidelberg, Germany; 6 OmicScouts GmbH, Freising, Germany WP 400 Dredging the Mass Spectrometry Data Lake for Hidden Information with Teradata Database and Business Intelligence Software; Alan Dickson ; Tony Ly ; Vackar Afzal ; Dalila Bensaddek ; Jens Hukelmann ; Angus Lamond ; Centre for Gene Regulation and Expression, Dundee, UK WP 40 Comparison of Data Processing Strategies for Optimal Detection of Protein-Protein Interactions; Gerhard Duernberger, ; Florian Stanek ; Johannes Doblmann ; Zuzana Demianova ; Karl Mechtler ; GMI - Gregor Mendel Institute of Molecular Plant Biology, Vienna, Austria; IMP - Research Institute of Molecular Pathology, Vienna, Vienna; IMP - Research Institute of Molecular Pathology, Vienna, Austria WP 40 Proteomics in Perl: A Streamlined Approach; Jeremy D Volkening ; Michael R Sussman ; University of Wisconsin- Madison, Madison, WI WP 40 RAId GUI: A Graphical User Interface for RAId Tandem Mass-Spectrometry Database Search Tool; Danny Lee ; Aleksey Ogurtsov ; Gelio Alves ; Yi-Kuo Yu ; National Center for Biotechnology Information, NLM, NIH, Bethesda, MD WP 404 Xcalibur Workbench: A Lua Based Data Browser; Michael W. Senko ; Graeme C McAlister ; Derek Bailey ; Thermo Fisher Scientific, San Jose, CA WP 405 CHORUS is Innovative and User Friendly Platform for Third Party Mass Spectrometry Software Integration; Andrey Bondarenko ; Andrii Loboda, ; Oleksii Tymchenko, ; Vladimir Moiseiev, ; Nathan Yates ; Mai Sun ; Michael J MacCoss 4 ; Brendan Maclean 4 ; Christine Wu 4 ; Brian C Searle 4 ; Sonia Ying Ting 4 ; Jimmy K Eng 4 ; Nick Shulman 4 ; Juergen H Cox 5 ; Chris Becker 6 ; InfoClinika, Bellevue, WA; TeamDev, Kharkiv, Ukraine; University of Pittsburgh, Pittsburgh, PA; 4 University of Washington, Seattle, WA; 5 Max Planck Institute for Biochemistry, Martinsried, Germany; 6 Protein Metrics Inc., San Carlos, CA Instrumentation: Mini/Portable/Fieldable MS WP 406 Fingerprinting of Falsified Artemisinin Combination Therapies (ACTs) via DART Ionization Coupled to a Compact Single Quadrupole Mass Spectrometer; Matthew Bernier ; Frederick Li ; Joseph LaPointe ; Brian D Musselman ; Paul Newton, 4 ; Facundo M Fernandez ; Georgia Institute of Technology, Atlanta, GA; IonSense, Inc. Saugus, MA; Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit (LOMWRU), Vientiane, Laos; 4 Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK WP 407 Explosive Detection Using a Portable Benchtop Cylindrical Ion Trap-Mass Spectrometer; Stephen Davila ; Corey Stedwell ; Daniel DeBord ; st Detect Corporation, Webster, TX WP 408 Establishing a Baseline for a Portable Stable Carbon Isotope Detection System; Brian Thomas ; Steve Taylor ; Tim Clarey ; Dave McIntosh ; University of Liverpool, Liverpool, UK; The King s University, Southlake, TX WP 409 Micro Mass Spectrometer Approach for Cometary Exploration; Ashish Chaudhary ; Friso van Amerom ; Tim Short ; Emily Barrentine ; Yun Zheng ; Daniel Glavin ; William Brinckerhoff ; Paul Mahaffy ; SRI International, St. Petersburg, FL; NASA GSFC, Greenbelt, MD WP 40 Development of Compact Laser Desorption/Ionization Time-of-Flight Mass Spectrometer for Planetary Missions; Xiang Li ; Stephanie Getty ; Andrej Grubisic ; Kyle Uckert 4 ; William Brinckerhoff ; Timothy J Cornish 5 ; PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

147 WEDNESDAY POSTERS WP 4 Scott Ecelberger 5 ; University of Maryland, Baltimore County, Greenbelt, MD; NASA Goddard Space Flight Center, Greenbelt, MD; University of Maryland, College Park, College Park, MD; 4 New Mexico State University, Las Cruces, NM; 5 C&E Research, Inc, Columbia, MD Mars Organic Molecule Analyzer (MOMA) Mass Spectrometer: Performance Testing in GC-MS and LD-MS Modes of Operation; Veronica Pinnick ; Ryan Danell ; Friso van Amerom ; Samuel Larson ; Arnaud Buch 4 ; Cyril Szopa 5 ; Xiang Li ; Andrej Grubisic 6 ; Ricardo Arevalo ; Stephanie Getty ; William Brinckerhoff ; Paul Mahaffy ; Francois Raulin 7 ; Fred Goesmann 8 ; University of Maryland, Baltimore County Greenbelt, MD; Danell Consulting, Inc. Winterville, NC; NASA GSFC, Greenbelt, MD; 4 Ecole Centrale, Paris, France; 5 Laboratoire Atmosphères, Paris, France; 6 University of Maryland, College Park, MD; 7 5Laboratoire Interuniversitaire des Systèms Atmosphériques, Paris, France; 8 Max Planck Institut für Sonnensystemforschung, Göttingen, Germany WP 4 Characterization of the Mars Organic Molecule Analyzer Mass Spectrometer Intrinsic Dynamic Range; Friso H.W. Van Amerom ; Xiang li ; Ryan Danell ; Veronica T Pinnick ; Stephanie Getty 4 ; Ricardo Arevalo 4 ; Andrej Grubisic 5 ; Lars Hovmand 6 ; William Brinckerhoff 4 ; Paul Mahaffy 4 ; Fred Goesmann 7 ; Mini-Mass Consulting, Inc, Hyattsville, MD; University of Maryland, Baltimore County Greenbelt, MD; Danell Consulting, Winterville, NC; 4 NASA GSFC, Greenbelt, MD; 5 University of Maryland, College Park, MD; 6 Linear Labs, Washington DC; 7 Max Planck Institut für Sonnensystemforschung, Goettingen, Germany WP 4 The Europa Mass Spectrometer for Planetary Exploration (MASPEX). A High-Resolution Multi- Pass Time-of-Flight Mass Spectrometer; Gregory P. Miller ; Jack Hunter Waite, Jr. ; Tim Brockwell ; John Roberts ; Keith S Pickens ; Ryan C. Blase ; Paul Wilson V ; Southwest Research Institute, San Antonio, TX; Southwest Research Institute, San Antonio, TX WP 44 Silence is Golden: Detector Radiation Shielding at Europa for MAss Spectrometer for Planetary EXploration (MASPEX); Ryan C. Blase ; Roland R. Benke ; Keith S. Pickens ; Gregory P. Miller ; Tim Brockwell ; John Roberts ; Paul Wilson IV ; J.H. Waite, Jr. ; Southwest Research Institute, San Antonio, TX; Atom Consulting LLC / Consultant to SwRI, Austin, TX WP 45 Development of an Integrated LC-MS Prototype for an in situ Mission to an Icy Body in the Solar System; Adrian Southard ; Stephanie Getty ; Jerome P Ferrance ; Brian N Stamos 4 ; Jamie E Elsila ; Manuel A Balvin ; Daniel P Glavin ; Daniel S Stewart ; Brandon J Colon-Curiel 5 ; Universities Space Research Association, Columbia, MD; NASA GSFC, Greenbelt, MD; Jf engineering, Charlottesville, VA; 4 University of Texas at Arlington, Arlington, TX; 5 University of Puerto Rico Mayaguez, Mayaguez, PR WP 46 Towards Remote Chemical Sensing Using an Aerodynamic Assisted Portable Mass Spectrometer; Yanbing Zhai ; Ting Jiang ; Wei Xu ; Beijing Institute of Technology, Beijing, China WP 47 Portable Multiple Ionization Sources Biological Mass Spectrometer; Jung-Lee Lin ; Ming-Lee Chu ; Chung- Hsuan Chen ; Academia Sinica, Taipei, Taiwan WP 48 Low Temperature Co-fired Ceramic (LTCC)-Packaged MEMS Micro-ion Source for Miniature Mass Spectrometry Applications; Charles B Parker ; Erich J Radauscher ; Kristin H Gilchrist ; Shane DiDona ; Zachary E Russell ; Stephen D Hall ; James B Carlson ; Sonia Grego ; Steven J Edwards ; Roger P Sperline ; M. Bonner Denton ; Brian R Stoner, ; Jeffrey T Glass ; Jason J Amsden ; Department of Electrical and Computer Engineering, Duke University, Durham, NC; Engineering and Applied Physics Division, RTI International, Research Triangle Park, NC; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ WP 49 Handheld and Portable DAPCI Source for Point and Shoot Applications: Towards Onsite in-situ Explosives Analysis; Fred Paul Mark Jjunju ; Simon Maher ; Stephen Taylor, ; Graham R Cooks 4 ; Department of Electrical Engineering and Electronics University of Liverpool, Liverpool, UK; University of Liverpool, Liverpool, UK; Q-Technologies Ltd, Liverpool, UK; 4 Department of Chemistry Purdue University, West Lafayatte, IN WP 40 Development of HPLC Methods for Use with Mobile Ambient Ionization Mass Spectrometry; Leonard Rorrer,III ; Mitch Wells ; FLIR Systems, Inc., West Lafayette, IN WP 4 Improving the Selectivity of a High Pressure Mass Spectrometry; Andrew Hampton; UNC - Chapel Hill, Chapel Hill, NC WP 4 Falling Through the Cracks: High Resolution Quadrupole Mass Spectrometry; Dave McIntosh ; Mariya Antony-Joseph ; Simon Maher ; John Ray Gibson ; Stephen Taylor ; University of Liverpool, Liverpool, UK WP 4 Utilizing Silicon on Insulator Materials to Fabricate Miniature Ion Traps for High Pressure Mass Spectrometry; Zachary Dyer ; Craig Cavanaugh ; Kenion Blakeman ; Tina Stacy ; Michael J Ramsey ; UNC Ramsey Group, Chapel Hill, NC; University of North Carolina at Chapel Hill, Chapel Hill, NC WP 44 Miniaturized Toroidal Ion Trap using Cylindrical Electrodes; Daniel Austin ; Jessica Higgs ; Kit White ; Yuan Tian ; Brigham Young University, Provo, UT WP 45 Overcoming the Tradeoff between Resolution and Sensitivity in Miniature Mass Spectrometry using Spatially Coded Apertures; Zachary E Russell, ; Evan X Chen ; Shane T DiDona ; Jason J Amsden ; Charles B Parker ; Scott D Wolter ; Ryan M Danell 4 ; Brian R Stoner 5 ; Gottfried Kibelka 6 ; Michael E Gehm ; David W Brady ; Jeffrey T Glass ; Duke University, Durham, NC; Stanford University, Stanford, CA; Elon Univesity, Elon, NC; 4 Danell Consulting, Inc. Winterville, NC; 5 RTI International, Raleigh, NC; 6 Xylem/OI Analytical, College Station, TX Instrumentation: New Developments in Ionization and Sampling (Sampling) WP 46 Coupling Thin-Layer Chromatography with Matrix Assisted Inlet Ionization for Small Molecule Analysis; Khoa Hoang ; Charles N McEwen, ; MStm, philadelphia, pa; University of the Sciences in Philadelphia, Philadelphia, PA; MSTM, LLC. Hockessin, DE WP 47 Interfacing UPLC to Mass Spectrometry via a Liquidjunction, Secondary Ultrasonic API Source; Steve Bajic ; David S Douce ; Gordon A Jones ; Waters Corporation, Manchester, England WP 48 Development and Optimization of an Inlet System for Desorption Atmospheric Pressure Photoionization Mass Spectrometry (DAPPI-MS); Kai Kroll ; Christine Polaczek ; Tiina Kauppila ; Anu Vaikkinen ; Hendrik Kersten ; Thorsten Benter ; University of Wuppertal, Wuppertal, Germany; University of Helsinki, Helsinki, Finland WP 49 Glove Box MS Interface for the Measurement of Reaction Kinetics of Airsensitive Compounds; Alan T. Taylor ; Ruth Dooley ; Mark Baumert ; Clive Aldcroft ; Mark Allen ; C. Logan Mackay ; Guy Lloyd-Jones ; University of Edinburgh, Edinburgh, Lothian; School of Chemistry, The University of Edinburgh Edinburgh, UK; Advion UK Ltd, Essex, UK 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 47

148 GENERAL WEDNESDAY INFORMATION POSTERS WP 40 Volatile Terpene Analysis in Cannabis, Spices and Fresh Produce by Tandem Mass Spectrometry Fitted with a Modified Plasma Source; Frank Kero ; Craig Young ; Heather Gamble ; Joshua Ye ; Lisa Cousins ; Chuck Joliffe ; Chai Yuan-Cheng ; Lin Jing-Chao ; PerkinElmer, Downers Grove, IL; Ionics, Bolton, Canada; PerkinElmer, Shanghai, China WP 4 A New Interface Design for Coupling a Liquid Stream to an Electron Ionization Source; Alexander Lekkas ; Dimitris Papanastasiou ; Emmanuel Raptakis ; Francesca Rigano ; Danilo Sciarrone ; Luigi Mondello, ; Fasmatech, Athens, Greece; Chromaleont s.r.l., Messina, Italy; Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, Messina, Italy WP 4 LC-MS with Cold EI The New System and Recent Applications; Svetlana Tsizin ; Aviv Amirav ; Alexander B Fialkov ; Tal Alon ; Tel Aviv University, Tel Aviv, Israel; Tel- Aviv University, Tel-Aviv WP 4 Study of Vaporization Surfaces in Liquid Chromatography Electron Ionization Mass- Spectrometry; Federica Bianchi ; Laura Magrini ; Nicolò Riboni ; Maria Careri ; Achille Cappiello ; University of Parma, Parma, Italy; University of Urbino, Urbino, Italy WP 44 DEI vs. LEI: A Novel, Advanced System for Interfacing Liquid Chromatography and Electron Ionization Mass Spectrometry; Achille Cappiello ; Maurizio Piergiovanni ; Giorgio Famiglini ; Veronica Termopoli ; Pierangela Palma ; University of Urbino, Urbino, Italy WP 45 Evaluation of an Induction-Based Fluidics System for Delivery of Low Volume (nl) Samples; Kelly Hanssen Smith ; Susan M Schulz ; Bryce F Doxzon ; Ernest H Braue ; Irwin Koplovitz ; Kathleen Housman ; Lee I Roberts ; Jonathan Oyler ; USAMRICD, Aberdeen Proving Ground, MD WP 46 AP-to-vacuum Inlet with New Features - Optimization of Desolvation Conditions in Liquid AP-MALDI MS; Jeff Brown, ; Pavel Ryumin ; Michael Morris ; Rainer Cramer ; University of Reading, Reading, UK; Waters, Wilmslow, UK WP 47 Gas Chromatography Plasma-Assisted Reaction Chemical Ionization Time of Flight Mass Spectrometry (GC-TOF-MS) for Identification and Quantification of Halogenated Compounds; Kunyu Zheng ; Hamid Badiei ; Kaveh Jorabchi ; Georgetown University, Washington, DC; PerkinElmer, Woodbridge, ON WP 48 A Novel Method for Online Analysis of Electronic Cigarette Aerosol; Christian Lindinger ; Alfons Jordan ; Philipp Sulzer ; Kostiantyn Breiev ; Kerstin M.M. Burseg ; Grant O Connell ; Eugen Hartungen ; Stefan S. Biel ; Xavier Cahours ; Stephane Colard ; Tilmann D. Märk, 4 ; IONICON Analytik GmbH., Innsbruck, AUSTRIA; Fontem Ventures B.V., Amsterdam, The Netherlands; SEITA - Imperial Tobacco Group, Fleury-les-Aubrais, France; 4 Institut für Ionenphysik und Angewandte Physik, Leopold- Franzens Universität Innsbruck, Innsbruck, Austria Ion Mobility: Fundamentals WP 49 Collision Cross Section (CCS) Measurements for Small Molecular Mixture by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry; Hu Miao ; Zhang Linzhou ; Xu Chunming ; Quan Shi ; China University of Petroleum, Beijing, China; State Key Laboratory of Heavy Oil Processing, Changping, Beijing WP 440 Assessment of using Projection Superposition Approximation (PSA) with Molecular Modeling to Compute Collision Cross Sections For Ion Mobility Spectrometry; Glenn Spangler; Technispan LLC, Lutherville, MD WP 44 Predicting Theoretical Collision-cross Sections for Peptides and Peptide Fragments; Bela Paizs ; Oscar Hernandez ; Daniel Chaplin ; Ash Buck ; Keith Richardson ; Jeff Brown ; Kevin Giles ; Zoltan Takats ; Bangor University, Bangor, UK; Waters, Wilmslow, UK; Imperial College, London, UK WP 44 Evaluation of Collision Cross Section Measurements Obtained by Uniform Field Drift Tube IM-MS: Insight into Instrument Settings and Theoretical Calculations; Sarah Stow ; Jody C May ; James N Dodds ; Andrzej Balinski ; Emma E Rennie ; Ruwan T Kurulugama ; John Fjeldsted ; John A McLean ; Vanderbilt University, Nashville, TN; Agilent Technologies, Santa Clara, CA WP 44 Hide-and -Seek: The effect of Localisation of Partial Charges on Ions on Their Calculated CCS Values; Lukasz Grzegorz Migas ; Eleanor Sinclair ; Christopher Gray ; Sabine Flitsch ; Perdita Barran ; University of Manchester, Manchester, UK WP 444 On the Structural Denaturation of Biological Analytes in Trapped Ion Mobility Spectrometry - Mass Spectrometry; Fanny Caroline Liu ; Samuel R. Kirk ; Christian Bleiholder ; Florida State University, Tallahassee, FL WP 445 Collision Cross Section Accuracy of Common MS Calibrants Across a Large Number of Measurements in Positive and Negative Ion Modes; Jody C. May ; Ruwan T Kurulugama ; George C Stafford ; John C Fjeldsted ; John A McLean ; Vanderbilt University, Nashville, TN; Agilent Technologies, Santa Clara, CA WP 446 Elucidating the Structural Heterogeneity of Biomolecules in the Gas Phase using Traveling Wave Ion Mobility Arrival Time Distributions; Sugyan Dixit ; Brandon T Ruotolo ; University of Michigan, Ann Arbor, MI WP 447 Towards using Trapped IMS in Structural Biology Applications; Christian Bleiholder ; Fanny C Liu ; Samuel R Kirk ; Meggie Young ; Mengqi Chai ; Florida State University, Tallahassee, FL; Florida State University, Tallahassee, FL WP 448 Characterizing Instrumental Parameters in Trapped Ion Mobility Spectrometry (TIMS) for Transmission and Preservation of Native Analyte Structures and Their Complexes; Samuel Kirk ; Christian Bleiholder ; Florida State University, Tallahassee, FL WP 449 Fundamentals of Trapped Ion Mobility Spectrometry: Fluid Dynamics; Melvin A. Park ; Karsten Michelmann ; Mark E Ridgeway ; Joshua Silveira ; Bruker Daltonics, Inc., Billerica, MA; Bruker Daltonik GmbH, Bremen, Germany WP 450 Decomposition Pathways during Explosive Analysis Using TIMS-MS and Molecular Dynamics; Alan McKenzie ; Mark E Ridgeway ; Melvin Park ; Francisco Alberto Fernandez Lima ; Florida Int l University, Miami, FL; Bruker Daltonic, Billerica, MA; Florida International University, Miami, FL WP 45 Improving Ion Mobility Mass Scan for the High Performance Ion Mobility Spectrometry Mass Spectrometry; Jianglin Wu ; Adam M Graichen ; Mark Osgood ; Ching Wu ; Excellims Corporation, Acton, MA WP 45 Structures for Lossless Ion Manipulations (SLIM) using Multilevel Traveling Wave Ion Escalators for Obtaining Ultrahigh Resolution Ion Mobility Separations; Ahmed M Hamid ; Yehia M Ibrahim ; Sandilya V. B Garimella ; Ian K Webb ; Liulin Deng ; Gordon A Anderson ; Spencer A Prost ; Jeremy A Sandoval ; Randolph V Norheim ; Erin S Baker ; Richard D Smith ; Pacific Northwest National Laboratory, Richland, WA WP 45 Development and Evaluation of Long Serpentine Path Traveling Wave SLIM Modules for High Resolution Ion Mobility Separations; Liulin Deng ; Yehia M Ibrahim ; Ahmed M Hamid ; Sandilya Garimella ; Ian Webb ; Xing Zhang ; Tsung-Chi Chen ; Xueyun Zheng ; Erin Baker ; PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

149 WEDNESDAY POSTERS Richard D Smith ; Pacific NW National Laboratory, Richland, WA; Pacific Northwest National Lab, Richland, WA WP 454 Comparing Ion Multiplexing Techniques: Tangible Enhancement for Ion Mobility-Mass Spectrometry; Brian H. Clowers ; Austen L. Davis ; Kelsey A Morrison ; Washington State University, Pullman, WA WP 455 A Comparative Study of nanoesi and ESI on an Atmospheric Pressure High Performance Ion Mobility Spectrometer; Mark Osgood ; Adam M Graichen ; Ching Wu ; Excellims Corporation, Acton, MA WP 456 Modeling Space Charge Effects on the Performance of Transversal Modulation Ion Mobility Spectrometry: A Numerical Approach; Cesar Barrios ; Guillermo Vidal-de- Miguel ; SEADM, Boecillo, Spain; Fossil Ion Technology S.L., Madrid, Spain WP 457 Coupling of High-Resolution Atmospheric Pressure Drift Tube Ion Mobility Spectrometry with High-Resolution Accurate Mass Orbitrap Mass Spectrometry; Joel D Keelor ; Anyin Li ; Brian H Clowers ; Facundo M Fernandez ; Georgia Institute of Technology, Atlanta, GA; Washington State University, Pullman, WA WP 458 Peak Width Analysis for Automated Detection of Unresolved Isomers in Ion Mobility; Matthew Brantley ; Michael Pettit ; Brett Harper ; Brooke Brown ; Touradj Solouki ; Baylor University, Waco, TX WP 459 Altering the Mobility-Time Continuum: Methods for Targeted, Yet Lossless, High Resolution Trapped Ion Mobility-Mass Spectrometry; Joshua Adam Silveira ; William Danielson ; Jacob Meier ; Mark E Ridgeway ; Melvin Park ; Bruker Daltonics, Billerica, MA; Danielson Software Consulting, Richland, WA WP 460 Comprehensive Electric Field Analysis of Resistive Glass Drift Tubes, Reflectrons, and Other Electro- Optical elements; Robert Jackson ; Matthew Breuer ; Paula Holmes ; Jeffrey DeFazio ; Instrumental Design Physics, LLC, Littleton, MA; Photonis USA, Sturbridge, MA; PHOTONIS USA, Lancaster, PA WP 46 Ion Mobility Coupled to Extended Mass Range Orbitrap for Structural Analysis of Large Proteins and Protein Complexes; Michael Poltash ; Kyle Fort ; David H Russell ; Texas A&M University, College Station, Texas; Utrecht University, Utrecht, The Netherlands; Texas A&M University, College Station, TX WP 46 Multistage Transversal Modulation IMS Coupled with IonMax Electrospray and Ion Trap MS to Provide a Modular ESI-IMS-MS Solution; Guillermo Vidal-de-Miguel ; Miriam Macia ; Gonzalo Arranz ; Alberto Tejero ; Fossil Ion Technology S.L., Madrid, Spain; SEADM, Boecillo, Spain WP 46 Development of a Drift Tube Mass Spectrometer Associated with Plasma Microjets; Joel Lemaire ; Bessem Brahim ; Michel Heninger ; Essyllt Louarn ; Helene Mestdagh ; Gérard Bauville ; Nicole Blin Simiand ; Et- Touhami Es-Sebbar ; Michel Fleury ; Stephane Pasquier ; Joao Santos Sousa ; Elsa Bauchard ; Julien Leprovost ; LCP, UMR8000, CNRS-Université Paris Sud, Université Paris Saclay, Orsay, France; LPGP, UMR8578, CNRS- Université Paris Sud, Université Paris Saclay, Orsay, France; AlyXan, Juvisy sur Orge, France Ion Structure/Energetics WP 464 Gas Phase Conformation of the Complex of Cyclodextrins with Amino Acids Revealed by Ion Mobility-Mass Spectrometry and Molecular Dynamics Calculation; Yinjuan Chen ; ZhiCheng Zuo ; Xinhua Dai ; Wenning Wang ; Chuanfan Ding ; Fudan University, Shanghai, China; National Institute of Metrology, Beijing, China; Fudan University, Shanghai, CN WP 465 Fragmentation of Nickel Nitrate Anions; Daniel Goebbert; The University of Alabama, Tuscaloosa, AL WP 466 Effects of Solvent Systems and Source Conditions on Protonation Site: The Case of p-aminobenzoic Acid; Amanda L Patrick ; Nicolas C Polfer ; University of Florida, Gainesville, FL WP 467 How Does Zinc Do It? Transformations of Alcohols by Gas-Phase Zinc Cation Complexes; Evan Perez ; Cassandra Hanley ; Theodore A Corcovilos ; John K Gibson ; Jonathan Martens ; Jos Oomens, 4 ; Michael J. Van Stipdonk ; Duquesne University, Pittsburgh, PA; Lawrence Berkeley National Lab, Berkeley, CA; Radboud University Nijmegen, Nijmegen, Netherlands; 4 University of Amsterdam, Amsterdam, The Netherlands WP 468 Synthesis and Study of Metal Oxide Cores through Sequential Fragmentation of Co(NO) ; Thomas Hester ; Daniel J. Goebbert ; The University of Alabama, Tuscaloosa, AL WP 469 Effects of D-amino Acids on the Gas Phase Acidity of Oligopeptides; Zachary Buen ; Jianhua Ren ; University of the Pacific, Stockton, CA WP 470 Fragmentation Mechanisms of Metal-yersiniabactin Complexes by Low-Energy Collision-Induced Dissociation Tandem Mass Spectrometry: An Empirical and Theoretical Study; Daryl Giblin ; Eun-Ik Koh ; Jan R Crowley ; Michael L Gross ; Jeffrey P Henderson ; Washington University in St. Louis, St. Louis, MO; Washington University in St. Louis, Saint Louis, MO WP 47 A Study of Diaryl Iodonium Complexes with Crown Ethers in the Gas Phase; Dmitri Zagorevski ; Michael F Aldersley ; Rensselaer Polytechnic Institute, Troy, NY WP 47 Underwater: A Computational Examination of the Gasphase Basicity Scale Weaker than 700 kj/mol; John Bartmess; University of Tennessee, Knoxville, TN WP 47 Potential Energy Surface of the Gd+ Reaction with O Mapped with GIBMS and Theory ; Maria Demireva ; Peter B Armentrout ; Department of Chemistry, University of Utah, Salt Lake City, UT WP 474 The Spider versus the Fly: Cationized Carbohyrdate Gas-phase Fragmentation Chemistry informs Saccharide Sequence Elucidation; Maha T Abutokaikah ; Ashley R. Wagoner ; Benjamin J. Bythell ; University of Missouri-St.Louis, St. Louis, MO WP 475 Structure, Thermochemistry, and Reactivity Studies of Gas-Phase Alkali Metal Ion-Coordinated ProLeu and LeuPro; Yasaman Jami Alahmadi ; Travis D Fridgen ; Memorial Univ of NL-Canada, St. John s, NL; Memorial University of NL, St. John s, Canada WP 476 Studies of Dihalogen Radical Anion Formation from Maleic Acid-Acene Compounds by Negative Chemical Ionization (NCI) and Time-of-Flight Mass Spectrometry (TOFMS); Daryl Giblin ; Jonathan P Hopwood ; Brittni A Qualizza ; Jacob W. Ciszek ; M. Paul Chiarelli ; Michael L Gross ; Washington University, St Louis, MO; Loyola University, Chicago, IL WP 477 Solution ph Can Affect Electrosprayed Metal-Ion Binding Patterns: IRMPD Structures of Metal-Ion/ Tripeptide Complexes; Robert C. Dunbar ; Jonathan Martens ; Giel Berden ; Jos Oomens ; Case Western Reserve Univ, Cleveland, OH; Radboud University Nijmegen, Nijmegen, Netherlands; Radboud University, Nijmegen, Netherlands WP 478 Prediction of CID/HCD Spectra by First-Principle Molecular Dynamics for Aimed Routine Compound ID; Michal Raab ; Robert Mistrik ; HighChem, Bratislava, Slovakia; HighChem, Bratislava, SK WP 479 Unimolecular Dissociation and Structures of Gaseous Self-Assembled [Ca(Uracil)4,5,6]+ Complexes; Ruodi Cheng ; Travis Fridgen ; Memorial university of NL, St. John s, Canada; Memorial University of NL, St. John s, NL 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 49

150 GENERAL WEDNESDAY INFORMATION POSTERS WP 480 Ligand Binding Energies and Structural Isomerism Accompanying Phosphine Exchange on the Cationic Gold Clusters; Marshall Ligare ; Jose Ulises Reveles ; Grant E Johnson ; Erin Baker ; Julia Laskin ; Pacific Northwest National Lab, Richland, WA; Virginia Commonwealth University, Richmond, VA WP 48 Metal Ion Adducts of Cysteine and Cysteine-Containing Peptide Radicals: Structure and Reactivity; Victor Ryzhov ; Michael Lesslie ; John Lawler ; Kai-Chi Justin Lau ; Alan C Hopkinson ; Northern Illinois University, DeKalb, IL; York University, Toronto, Canada WP 48 Mass Spectrometric and Computational Investigation of the Protonated Carnosine Carboplatin Complex Fragmentation; Ida Ritacco ; Emilia Sicilia ; Tamer Shoeib, ; Mohamed Korany ; Nino Russo ; Dipartimento di Chimica e Tecnologie Chmiche, Università della Calabria, Calabria, Italy; Department of Chemistry, The American University in Cairo, New Cairo, Egypt; Centre for Analytical Science, Department of Chemistry, Loughborough University, Loughborough, UK LC-MS: Sample Preparation (Part ) WP 48 Improved Recovery, Reproducibility and Matrix Effects with an Advanced Technology in Solid Phase Extraction (SPE) Oasis PRiME HLB; Xin Zhang ; Jonathan Danaceau ; Erin Chambers ; Waters, Milford, MA WP 484 Comprehensive Analysis of Protein Glycosylation using NGAG Method; Shisheng Sun ; Punit Shah ; Shadi Toghi Eshghi ; Hui Zhang ; Johns Hopkins University, Baltimore, MD WP 485 Methylmalonic Acid: Evaluation of Sample Preparation and Simplicity of Method Implementation using Automated Sample Preparation Prior to LC-MS/MS Analysis; Rhys Jones ; Helen Lodder ; Lee Williams ; Geoff Davies ; Alan Edgington ; Adam Senior ; Steve Jordan ; Claire Desbrow ; Paul Roberts ; Victor Vandell ; Dan Menasco ; Biotage GB Limited, Cardiff, UK; Biotage GB Limited, Cardiff; Biotage LLC, Charlotte, NC WP 486 Integration of Steroids Analysis in Serum using LC-MS/ MS with Full-Automated Sample Preparation; Toshikazu Minohata ; Kawakami Daisuke ; Shimadzu Corporation, Kyoto, Japan WP 487 Determination of Pharmaceuticals in Wastewater using Online SPE Coupled to Liquid Chromatography Mass Spectrometry; Andreas Bruchmann ; Claudia vom Eyser ; Thorsten Teutenberg ; Jochen Tuerk ; Axel Semrau GmbH & Co.KG, Sprockhoevel; IUTA, Duisburg, Germany WP 488 Applying a Tangential Flow Filtration Approach for Low Concentration Proteomics Sample Preparation; Woodard Toni ; Zhe Wang ; Ma Hongyan ; Saurav Malla ; Si Wu ; University of Oklahoma, Norman, OK WP 489 SPE Method Optimization and Transfer to an Automated Sample Preparation Platform for Low Level Catecholamine Analysis using LC-MS/MS; Alan Edgington ; Adam Senior ; Lee Williams ; Victor Vandell ; Geoff Davies ; Helen Lodder ; Rhys Jones ; Steve Jordan ; Claire Desbrow ; Paul Roberts ; Dan Menasco ; Biotage GB Limited, Cardiff, UK; Biotage GB Limited, Cardiff; Biotage LLC, Charlotte, NC WP 490 Dual Immobilized Enzyme Reactors for Peptide, Glycan, and Glycopeptide online LC-MS/MS Analysis; Kerry Wooding ; Rui Zhu ; Yehia Mechref ; Texas Tech University, Lubbock, TX WP 49 Handy Devices for Quantitative Capillary Blood Microsampling; Shinobu Kudoh ; Ippei Takeuchi ; Shimadzu Techno-Research, Inc., Ohta-Ku, Tokyo; Shimadzu Corp, Kyoto, Japan WP 49 Rapid, Efficient and Reproducible Sample Preparation for Quantitative Proteomics by a Surfactant-Aided Precipitation/On-Pellet Digestion Strategy; Shichen Shen ; Bo An ; Jun Li ; Xiaomeng Shen ; Chengjian Tu ; Jun Qu ; University at Buffalo, Buffalo, NY WP 49 A Quantitative LC-MS Method to Determine Lutein Levels in Whole Human Blood Using Dried Blood Spot Analysis (DBS); Carl Norén ; Todime Reddy ; Stefan Ehling ; Abbott Nutrition, Columbus, OH WP 494 Fully Automated Evaluation of Dextrorphan Extraction Procedure by DBS In-Tips, analyzed with RTC-LC-MS/ MS; Sylvain R Letarte ; SERGE AUGER ; Pierre Picard ; Phytronix Instruments, Boisbriand, Canada; Phytronix Technologies, Quebec, QC; Phytronix Technologies, Quebec, Canada WP 495 In-depth Proteomic Quantification of Cell Secretome in Serum-Containing Conditioned Medium; Yejing Weng ; Zhigang Sui ; Yichu Shan ; Lihua Zhang ; Yukui Zhang ; Chinese Academy of Sciences, Dalian, China WP 496 A Multiwell Magnetic Mixer for Automated Sample Preparation; Chang Liu ; Don W Arnold ; Thomas R Covey ; SCIEX, Concord, ON; SCIEX, Redwood City, CA WP 497 Quantitative Analysis of low-abundance Serological Proteins with Peptide Affinity-Based Enrichment and Pseudo-Multiple Reaction Monitoring by Hybrid Quadrupole Time-Of-Flight Mass Spectrometry; Kwang Hoe Kim, ; Yeong Hee Ahn ; Eun Sun Ji ; Ju Yeon Lee ; Jin Young Kim ; Hyun Joo An ; Jong Shin Yoo, ; Korea Basic Science Institute, Chungbuk, South Korea; Chungnam National University, Daejeon, South Korea; Cheongju University, Cheongju, South Korea WP 498 Advancing the MStern Blotting PVDF Membrane- Based Peptide Fractionation in a 96 Well Format; Sebastian Berger, ; Saima Ahmed ; Michaela Helmel ; Hanno Steen ; Boston Children s Hospital, Boston, MA; Harvard Medical School, Boston, MA; Boston Children s Hospital, Harvard Medical School Boston, MA WP 499 Quantification of Celecoxib in Rat Skin using LC-MS/MS Method after Collagenase Digestion and Bead Lysis; Raghupathi Aleti ; Ilayaraja Kalaikadhiban ; Sailakshmi Chennupati ; Devender Reddy Ajjala ; Ramakrishna Nirogi ; Suven Life Sciences Ltd, Hyderabad, Telangana WP 500 Basic Reverse Phase Fractionation on OasisHLBuElution Plates as a Fast Sample Preparation Technique for LCMSMS Analysis of Low Protein Amounts; Robert N O Meally ; Tatiana N. Boronina ; Maximilian Konig ; Felipe Andrade ; Robert N Cole ; Johns Hopkins University School of Medicine, Baltimore, MD WP 50 LC/MS/MS Analysis with On-line Cartridge for Removal of Phospholipids from Protein Precipitation Biological Fluid Samples; David S. Bell ; Xiaoning Lu ; Hillel K. Brandes ; Craig R Aurand ; Sara Smith ; Carmen T. Santasania ; MilliporeSigma, Bellefonte, PA WP 50 Different Approach for Improvement of Low Recovery Dried Blood Spot Storage Sample and Its Application in Bioanalytical Assay; Dawei Zhou ; John Ma ; Mohamed Osman ; Xinping Fang ; WuXi AppTec Co., Plainsboro, NJ WP 50 Simultaneous Quantitation of Five Leachables in Lipid Emulsions by LC-MS/MS Using,-Dimethoxypropane; Yousheng Hua ; Jim Story ; Peifeng Hu ; Dennis Jenke ; Christopher M Jones ; Baxter Healthcare, Round Lake, IL WP 504 A Conventional Procedure to Reduce Asn Deamidation Artifacts during Trypsin Peptide Mapping; Yekaterina Kori, ; Rekha Patel ; Alyssa Neill ; Hongcheng Liu ; University of Massachusetts Amherst, Amherst, MA; Alexion Pharmaceuticals, Cheshire, CT PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

151 WEDNESDAY POSTERS Lipids: Profile Analysis WP 505 Optimization of Female Sex Hormone Extraction for Semi-Quantitative Analysis in Human Plasma by UHPLC/MS/MS; Juan Aristizabal Henao ; Richard W Smith ; Ken D Stark ; University of Waterloo, Waterloo ON, Canada WP 506 Lipidomic Profiling of Biological Samples using Off-Line Two-Dimensional High-Performance Liquid Chromatography-High Resolution Mass Spectrometry; Monica Narvaez-Rivas ; Qibin Zhang ; University of North Carolina at Greensboro, Kannapolis, NC; University of North Carolina Greensboro, Greensboro, NC WP 507 UHPLC Combined with Ultra-high Resolution QTOF-MS for Rapid Lipidomic Profiling of Serum for Discovery of Lipid Biomarkers of Parkinson s Disease; Jaspaul Tatlay ; Dorothea Mung ; Richard Camicioli ; Liang Li ; University of Alberta, Edmonton, Canada; Neuroscience and Mental Health Institute, Department of Medicine, Edmonton, AB, Canada WP 508 Environmental Lipidomics: Examining the Case of Pansteatitis in Mozambique Tilapia; John Bowden ; Jeremy Koelmel ; Stephen E Somerville ; Timothy J Garrett ; Richard A Yost ; Robert Chapman 4 ; Louis Guillette ; NIST, Charleston, SC; University of Florida, Gainesville, FL; Medical University of South Carolina, Charleston, SC; 4 South Carolina Department of Natural Resources, Charleston, SC WP 509 Comprehensive Lipid and Protein Analysis of Size Fractionated Serum Lipoproteins in Normal versus Dyslipidemic Subjects; Michael Gardner ; Zsuzsanna Kuklenyik ; David M Schieltz ; Bryan A Parks ; Jon Rees ; Lisa G McWilliams ; Yulanda Williamson ; Christopher Toth ; Jeffrey Jones ; Michael Andrews ; John R Barr ; Centers for Disease Control and Prevention, Atlanta, GA WP 50 Reverse Phase LC ESI-QTOF Methodology for the Analysis of Lipids in Whole Blood; Ralph Hindle ; Ken D Stark ; Juan J Aristizabal Henao ; Richard W Smith ; Sheher Mohsin 4 ; Vogon Laboratory Services, Alberta, Cochrane, Canada; Department of Kinesiology, University of Waterloo, Waterloo ON, Canada; University of Waterloo Mass Spectrometry Facility, University of Waterloo, Waterloo ON, Canada; 4 Agilent Technologies, Schaumburg, IL WP 5 The Application of Lipidomics to the Study of Hepatocellular Carcinoma (HCC) Induced by Low Dose, High-Energy, High Charge Ions (HZE); Brooke L Barnette ; Shinji K Strain ; Cheryl F Lichti ; Yu Yongjia ; Robert Ullrich ; Mark R Emmett ; University of Texas Medical Branch at Galveston, Galveston, TX WP 5 Analysis of Lipids in Spinal Cords of Experimental Autoimmune Encephalomyelitis (EAE) Mice using On- Line Photochemical Derivatization and Tandem Mass Spectrometry; Leelyn Chong ; Xiaoxiao Ma ; Yu Xia ; Zheng Ouyang ; Purdue University, West Lafayette, IN WP 5 Lipid Peroxidation Profiles in Acute Hepatic Ischaemia- Reperfusion Injury; Michael Dunn ; Aimen Amer ; Margaret Knight ; Clair Roper ; Peter Blain ; Matthew Wright ; Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, UK; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK WP 54 The Comparison of Glycosphingolipids in an Epithelial Ovarian Cancer Cell Line and a Nontumorigenic Epithelial Ovarian Cell Line using MALDI-MS; Krishani Kumari Rajanayake ; William Taylor ; Dragan Isailovic ; The University of Toledo, Toledo, OH WP 55 Fatty Acid Re-Esterification in Adipose Tissue - Beneficial Futile Metabolite Cycling; Ondrej Kuda ; Martina Rombaldova ; Jan Kopecky ; Institute of Physiology, CAS, Prague, Czech Republic WP 56 Analysis of Phospholipids, Lipid A and Sterols from Outer Membrane Vesicles Shed by Acinetobacter baumanniidu0; Geul Bang ; Semin Park ; Sung-Ho Yun ; Seung Il Kim ; Man Ho Choi ; Yun-Gon Kim 4 ; Young Hwan Kim ; Korea Basic Science Institute, Cheongju, Korea; Korea Basic Science Institute, Daejeon, Korea; Korea Institute of Science and Technology, Seoul, Korea; 4 Soongsil University, Seoul, Korea WP 57 Differing Effects of Red-tide Exposure on the Lipidome of Phytoplankton Competitors; Scott Hogan ; Remington Poulin ; Julia Kubanek ; Facundo M Fernandez ; Georgia Institute of Technology, Atlanta, GA WP 58 Fusarium oxysporum f. spcubense Aggressiveness Investigated by MALDI-TOF-MS Lipid Profile; Daniele F. O. Rocha ; Cristiane M. S. Cunha ; Katia R. A. Belaz ; Fabio N. dos Santos ; Robert H. Hinz ; Adriana Pereira ; Alexandre Visconti ; Ester Wicket ; Lidiane Maria de Andrade 4 ; Claudio A. O. Nascimento 4 ; Nogueira Marcos Eberlin ; Thomson Mass Spectrometry Laboratory-UNICAMP, Campinas, Brazil; Flora Biotecnologia Ltda, Itajaí, Brazil; Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina- EPAGRI, Itajaí, Brazil; 4 Chemical Engineering Department of Polytechnic School of University of São Paulo, São Paulo, Brazil WP 59 Direct Analysis of Phospholipids in Biological Tissues Using Internal Extractive Electrospray Ionization Mass Spectrometry; Haiyan Lu ; Jianyong Zhang ; Wei Zhou ; Yiping Wei ; Huanwen Chen 4 ; East china university of Technology, Nanchang, China; Second Affiliated Hospital of Nanchang University, Nanchang, China; East China Institute of Technology, Nanchang, China; 4 East China University of Technology, Nanchang, Mainland WP 50 Ambient Ionization Methods and Liquid Chromatography Mass Spectrometry Analysis of Human Melanoma Biopsies; Louis Searcy ; Candice Ulmer ; Matthew Kazaleh ; Michael Costanzo ; Nikolaus Gravenstein ; Richard A. Yost ; University of Florida, Gainesville, FL; University of Florida, Gainesville, FL WP 5 In-situ and in-vitro Regional Analysis of Lipids in Mammalian Vitreous Humor using MALDI-MS; Abby Schnepf ; M. Cecilia Yappert ; Douglas Borchman ; Department of Chemistry, University of Louisville, Louisville, KY; Department of Chemistry University of Louisville, Louisville, KY; Department of Ophthalmology and Visual Sciences University of Louisville, Louisville, KY WP 5 Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS) Based on Fragmentation Profile of Glycerophospholipids; Richard Schäffer ; Tamas Juhasz ; Tamas Karancsi ; Steven D Pringle ; Zoltan Takats ; Julia Balog, ; Waters Research Center, Budapest, Hungary; Waters, Wilmslow, UK; Imperial College, London, UK WP 5 Detection of Altered Brain Lipids by LC-MS and Imaging Mass Spectrometry in Demyelinating, Remyelinating and Dysmyelinating Mouse Models; Xiaoping L. Hronowski ; Raj Maganti ; Brian T Wipke ; Robert Dunstan ; Peter Juhasz ; Biogen Inc., Cambridge, MA WP 54 A General Normal Phase HPLC Separation Hyphenated with HR/AM Tandem Mass Spectrometric Method for Whole Lipidomics Profiling; Qifeng Zhang ; Michael J.O. Wakelam ; Babraham Institute, Cambridge, UK WP 55 Comprehensive Profiling of Lipids in Chicken Skin by High Resolution Mass Spectrometry with Online Information Dependent Acquisition Workflow; Yushi Pan ; Kevin zhang ; Huaidong Yu ; Yong Fang 4 ; Pan YS, Nanjing, China;, Beijing, Beijing; Yu HD, Beijing, China; 4 Fang Y, Nanjing, China 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

152 GENERAL WEDNESDAY INFORMATION POSTERS WP 56 Phospholipid Profiling by Two Distinct MRM Measurements to Identify Phospholipid s Class and Fatty Acid Composition; Tsuyoshi Nakanishi ; Masaki Yamada ; Suzumi Tokuoka ; Yoshihiro Kita ; Takao Shimizu, ; Shimadzu Corporation, Kyoto, Japan; The University of Tokyo, Tokyo, Japan; National Center for Global Health and Medicine, Tokyo, Japan WP 57 Lipid Profiling of Madin-Darby Canine Kidney Cells and Its Lipid Changes Induced by Aristolochic Acid(I) using Two-Dimensional LC-MS; Honggang Nie ; Liu Ranran ; Yang Youyou ; Liu Huwei ; Bai Yu ; Peking University, Beijing, China; Chinese Oil & Foodstuffs Corporation (COFCO) Nutrition and Health Research Institute, Beijing, China WP 58 High-Throughput Lipidomics Workflow for Identification and Quantification of >000 Lipids in Different Lipid Classes; Richard John Robinson ; Fred Hubbard ; Philip Michael Charpia ; Alexandria Conner ; Anne Evans ; Luke Miller ; Steve Watkins ; Don Harvan ; Metabolon, Inc., Durham, NC; Metabolon, Inc., Durham, NC WP 59 Lipidomic Analysis of Cultured Cells Lines; Finnur Freyr Eiriksson, ; Manuela Magnusdottir ; Halldorsson Skarpheðinn ; Ottar Rolfsson ; Helga M. Ogmundsdottir ; Margrét Thorsteinsdottir, ; ArcticMass, Reykjavik, Iceland; University of Iceland, Reykjavik, Iceland WP 50 Profiling Lipids in Plants Using Infusion and Chromatography Based High Resolution Mass Spectrometry Methods with Automated Data Processing; Yelena A. Adelfinskaya ; Daniel J J Gachotte ; Jeffrey R Gilbert ; Jesse L Balcer ; Laura L Wayne ; Dow AgroSciences, Indianapolis, IN WP 5 Lipid and Fatty Acid Analysis in Grape Seeds and Grape Seed Oil with High Resolution Mass Spectrometry; Zareen Khan ; Akanksha Singh ; Ahammed Shabeer T.P. ; Manoj Pillai ; Kaushik Banerjee ; National Referral Laboratory, ICAR-National Research Centre for Grapes, Pune, Maharashtra, India; SCIEX, Gurgaon, Haryana; SCIEX, Gurgaon, Haryana India WP 5 Methods to Analyze Beneath the Surface of Oil Seeds using Mass Spectrometry; Suresh Annangudi ; Holly Henderson ; Callee Walsh ; Trust T Razunguzwa ; Jeffrey R Gilbert ; Dow AgroSciences, Indianapolis, IN; Protea Biosciences, Inc. Morgantown, WV WP 5 Accelerating Lipid Profiling Acquisition Strategies using Differential Mobility Spectrometry and SWATH Data Collection; Eva Duchoslav ; Brad T Patterson ; Larry J Campbell ; Yves J C LeBlanc ; SCIEX, Concord ON, Canada; SCIEX, Melbourne VIC, Australia WP 54 A Simple, Flexible, and Automated Infusion System for Lipidomic Analysis using Mass Spectrometry; Jeff McDonald ; Steve Stiller ; UT Southwestern Medical Center, Dallas, TX; LEAP Technologies, Carrboro, NC WP 55 The Rapid Evaporative Ionisation Mass Spectrometry (REIMS) iknife Identifies Gynaecological Tissue with Excellent Accuracy in the ex-vivo and in-vivo Setting; David L Phelps ; Julia Balog, ; Louise Gildea ; Mona El- Bahrawy ; Abigail Speller ; Robert Brown ; Sadaf Ghaem- Maghami ; Zoltan Takats ; Imperial College, London, UK; Waters Corporation, Budapest, Hungary; Imperial College London, South Kensington Campus London, UK WP 56 REIMS has the Potential to Improve Diagnostic of Hepatocellular Carcinoma Liver Perspectives towards Intraoperative Molecular Diagnostics; Tiffany Porta ; Julia Balog ; Flora Olivier ; Pierre-Maxence Vaysse ; Ulf P. Neumann ; Steven W.M. Olde Damink 4 ; Thorsten Cramer ; Ron M.A. Heeren ; M4I Institute - Maastricht University, Maastricht, The Netherlands; Waters Corporation, Wilmslow, UK; RWTH Aachen, Aachen, Germany; 4 Maastricht University Medical Center +, Maastricht, The Netherlands Metabolomics: Clinical Applications WP 57 Identifying Sweet-spots of Preeclamptic Urine Metabolomics with High Resolution and Accurate Mass Measurements; Hongwu Jing ; Yu Cao ; Arpad Somogyi ; Guomao Zhao ; Michelle Axe ; Catalin S Buhimschi ; Irina A Buhimschi ; Vicki H Wysocki ; The Ohio State University, Columbus, OH; Nationwide Children s Hospital, Columbus, OH WP 58 Integrative Pathway Analysis of Metabolic Signature in Bladder Cancer: A Linkage to Cancer Genome Atlas Project and Prediction of Survival; Nagireddy Putluri; Baylor College of Medicine, Houston, TX WP 59 Development of Highly Sensitive Quantification Method for Testosterone Human Serum by Liquid Chromatography Tandem Mass Spectrometry; Vasanta Putluri ; Sriramya Donepudi ; Feng Jin ; Andre Szczesniewski ; Vadiraja B Bhat ; J Peter Cook ; Dolores J Lamb ; Arun Sreekumar ; Nagireddy Putluri ; Baylor College of Medicine, Houston, TX; Agilent Technologies, Wilmington, DE WP 540 Targeted Metabolomics of Liver Donor Allografts: A Clinical Application; Jeffrey A Culver, ; Andrew V Zelenin, ; Christopher Petucci, ; Stephen J Gardell, ; John B Seal ; Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL; Southeast Center For Integrated Metabolomics, Gainesville, FL; Ochsner Medical Center, New Orleans, LA WP 54 Metabolomics and Flux Analysis Informed on the Mechanism of Response of AML to IACS-0759, a Potent and Selective OXPHOS Inhibitor; Pietro Morlacchi; UT MD Anderson Cancer Center (IACS/CCCT), Houston, TX WP 54 Use of a Novel C8-Based Stationary Phase for Human Urine Metabolite Profiling By UHPLC-High Resolution Accurate Mass Spectrometry (HRAM); Alan P McKeown ; Catherine Ortori ; Geoffrey Faden ; Advanced Chromatography Technologies Ltd, Aberdeen; The School of Pharmacy, University of Nottingham, Nottingham, UK; MACMOD Analytical Inc., Chadds Ford, PA WP 54 Discriminatory Ability of Ambient Ionisation Mass Spectrometry in Analysing Skin Secretions: A Non- Invasive Diagnostic Test of Lower Airway Infection?; Emmanuelle Bardin ; Frances Bolt ; Eric Alton, ; Andrew Bush, ; Jane Davies, ; Zoltan Takats ; Imperial College London, South Kensington Campus London, UK; Royal Brompton and Harefield NHS Foundation Trust, London, UK WP 544 Comprehensive Cerebrospinal Fluid Metabolomic Profiling for Mechanism Study of Idiopathic Intracranial Hypertension; Liang Zhao ; Xiali Zhong ; Abhay Moghekar ; Thomas Hartung ; Johns Hopkins University, Baltimore, MD WP 545 Isotope-based Metabolomic Analysis of Human Samples; Kevin Y Cho ; Ying-Jr Amanda Chen ; Nathaniel G Mahieu ; Gary Patti ; Washington University School of Medicine, St. Louis, MO WP 546 Integrative Metabolomic and Proteomic Analysis Reveals Biomarkers Related to Oxidative Stress in Traumatic Brain Injury; Veera Venkata Ratnam Bandaru ; Sartaj Ahmad Mir ; Frederick Korley ; Robert D Stevens ; Akhilesh Pandey ; Johns Hopkins University School of Medicine, Baltimore, MD WP 547 Bioaccessible Phytochemicals from Black Raspberries after Interaction with Saliva Determining Exposure in the Oral Cavity Using a Metabolomics Approach; Ken M Riedl ; Jennifer Ahn-Jarvis ; Matthew Teegarden ; Thomas Knobloch ; Christopher Weghorst ; Purnima Kumar ; Steven Clinton ; Yael Vodovotz ; Steven J Schwartz ; The Ohio State University, Columbus, OH PAGE 5 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

153 WEDNESDAY POSTERS WP 548 Studying Individual Differences in Cancer Drug Efficacy using Metabolomics of a Panel of Human Cell Lines; Thomas Hankemeier ; Liewei Wang ; Ruud Berger ; Amy Harms ; Slavik Koval ; Sabine Bos ; Silvia Marin 4 ; Marta Cascante 4 ; Dick Weinshilboum 5 ; Rima Kaddurah-Daouk 6 ; Leiden University, Leiden, South Holland; Clinical Pharmacology, Mayo Clinic, Rochester, MN; Leiden University, Leiden, Netherlands; 4 University of Barcelona (UB); 5 Mayo Clinic, Rochester, MN; 6 Duke University Medical Center, Durham, NC WP 549 Lipidomic Analysis of Endometriosis Foci by Direct Tissue-Spray Mass Spectrometry; Vitaliy Chagovets ; Zhihao Wang ; Anna Borisova ; Vadim Lagutin ; Natalia Starodubtseva ; Andrey Kozachenko ; Konstantin Chingin ; Chen Huanwen ; Leila V Adamyan ; Vladimir Frankevich ; Gennady Sukhikh ; Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Healthcare of the Russian Federation, Moscow; Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang, China Metabolomics: Untargeted Metabolite Profiling (Animal/Human/Other) WP 550 Drosophila as a Model System for Microbiome Research - a GCMS Based Metabolomics Approach; Bhavapriya Vaitheesvaran ; John McMullen ; Anthony Macherone ; Angela E Douglas ; Justin R Cross ; Memorial Sloan Kettering Cancer Center, New York, NY; Cornell University, Ithaca, NY; Agilent Technologies, Little Falls, DE WP 55 Lipidome and Metabolome Analyses of Mouse Hippocampus in Response to Low-dose X-ray Irradiation using Liquid Chromatography-Mass Spectrometry; Fereshteh Zandkarimi ; Jeffrey Morré ; Jacob Raber ; Claudia S Maier ; Oregon State University, Department of Chemistry Corvallis, OR; OHSU, Dep. Behavioral Neuroscience, Neurology, & Radiation Medicine, ONPRC, Portland, OR WP 55 Comparative High Resolution Metabolomics of Metastatic vs. Non-Metastatic Tumors in a Murine Medulloblastoma Model; Danning Huang ; Martin R L Paine ; Jingbo Liu ; Sophia Banton ; Shuzhao Li ; Tobey MacDonald ; Facundo M Fernández ; Georgia Institute of Technology, Atlanta, GA; Emory University School of Medicine, Atlanta, GA WP 55 Caloric Restriction Improves Diabetes-Induced Nonalcoholic Fatty Liver Diseases by Changing Metabolism; Youngae Jung ; Geum-Sook Hwang, ; Western Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea; Department of Life Science, Ewha Womans University, Seoul, Republic of Korea WP 554 Comprehensive HPLC-MS Metabolomics Analysis of Brain Tissue Reveals Age, Region, and Gender-Specific Effects of Centella asiatica; Parnian Lak ; Nora Gray ; Luisa Zini ; Phillip Seitzer ; Christopher Harris ; Joseph Quinn, 4, 5 ; Amala Soumyanath ; Jan Fred Stevens ; Claudia Maier ; Oregon State University, Corvallis, OR; Oregon Health and Sciences University, Portland, OR; Proteome Software, Portland, OR; 4 PADRECC, Portland, OR; 5 Portland Veterans Affairs Medical Center, Portland, OR WP 555 Global Lipid Profiling in Aging Mouse Model associated with Osteoporosis; Eun-ha Kim ; Geum-Sook Hwang ; KBSI Western Seoul Center, Seoul, Republic of Korea WP 556 Metabolomics Approach for Mice Serum Associated with Epidermal Growth Factor Receptorand BaPinduced Mouse Lung Tumor Genesis using Liquid Chroma; Hui Ling Lee; Fu Jen Catholic University, New Taipei, TAIWAN WP 557 Global Metabolomic Profile Differentially Segregates with Calcium Supplementation in Mice Fed a High- Fat Western Style Diet; Muhammad Aslam ; Li Zhang ; Christine Bassis ; Maureen Kachman ; Charles Burant ; Ingrid Bergin ; James Varani ; Department of Pathology, Internal Medicine, Medical of School, University of Michigan, Ann Arbor, MI; Michigan Regional Comprehensive Metabolomics Resource Center; University of Michigan, Ann Arbor, MI; Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI WP 558 LC-MS/MS Based Metabolomic Analysis of the Effect of Biogenic Amine in a LPS-induced Sepsis Mouse Model; Yu-Min Liu ; Soo-Ray Wang ; Maw-Rong Lee ; National Chung-Hsing University, Taichung, Taiwan (R.O.C.); Chung Shan Medical University, Taichung, Taiwan (R.O.C.) WP 559 Diabetes Markers: Using Orbitrap HRAM and a New Workflow for Differential Analysis of Zucker Rat Plasma Metabolome; Junhua Wang ; Maciej P Bromirski ; Ralf Tautenhahn ; David Peake 4 ; Kiyonami Reiko 4 ; Tina Settineri 4 ; Ken Miller 4 ; Thermo Fisher Scientific Inc, San Jose, CA; Thermo Fisher Scientific, Bremen, DE; Thermo Fisher Scientific, San Jose, CA; 4 ThermoFisher, San Jose, CA WP 560 Effects of Dietary Different Doses of Copper and High Fructose Feeding on Rat Fecal Metabolome; Biyun Shi, ; Ming Song ; Xiaoli Wei, ; Xinmin Yin, ; Dale Schuschke 4 ; Imhoi Koo, ; Craig McClain, 5 ; Xiang Zhang,,5 ; Department of Chemistry, University of Louisville, Louisville, KY; Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY; Department of Medicine, University of Louisville, Louisville, KY; 4 Department of Physiology and Biophysics, University of Louisville, Louisville, KY; 5 Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY WP 56 Optimization of Tissue Extraction for GCMS Metabolomic Analysis Reveals Altered Metabolism of Barbiturates in a Polycystic Kidney Disease Model; Hayley Abbiss,, ; Garth L. Maker, 4, 5 ; Gabrielle C. Musk 4, 6 ; Catherine Rawlinson, 4, 5, 7 ; Joel P.A. Gummer, 4 ; Patricia A. Fleming 4 ; Jacqueline K. Phillips 8 ; Mary C. Boyce 9 ; John Moncur ; Robert D. Trengove, 4, 5 ; Murdoch University, Perth, Western Australia; SpectralWorks, Cheshire, UK; Separation Science and Metabolomics Laboratory, Perth, Australia; 4 Murdoch University, Perth, Australia; 5 Metabolomics Australia, Western Australian Node, Perth, Australia; 6 The University of Western Australia, Perth, Australia; 7 Curtin University, Perth, Australia; 8 Macquarie University, Sydney, Australia; 9 Edith Cowan University, Perth, Australia WP 56 Spatial -temporal Analysis of Metabolite Expression in Xenopus laevisembryos during Early Development.; Jennifer Arceo ; Nicole M Schiavone ; Danielle A Boley ; Norman J Dovichi ; University of Notre Dame, Notre Dame, IN; University of Notre Dame, Notre Dame, IN WP 56 Capillary Zone Electrophoresis-Electrospray Ionization- Mass Spectrometry for Xenopus laevismetabolomic Analysis; Nicole Schiavone ; Jennifer Arceo ; Danielle A Boley ; Norman J Dovichi ; University of Notre Dame, Notre Dame, IN WP 564 Evaluating the Metabolic Impact of Feeding Baboons a High Fat, High Caloric Diet using an Accurate Mass GC/QTOF; Mark Libardoni ; Matthew Curtis ; Stephan Baumann ; Southwest Research Institute, San Antonio, TX; Agilent Technologies, Santa Clara, CA WP 565 Profiling and Quantitative Analysis of Small Molecule Metabolites and Neurotransmitters in Crustacean Hemolymph/Neuronal Tissues Using Reversed-Phase and Mix-Mode LC-MS/MS; Qinjingwen Cao ; Chuanzi OuYang ; Xuefei Zhong ; Lingjun Li, ; University of 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 5

154 GENERAL WEDNESDAY INFORMATION POSTERS Wisconsin-Madison, Madison, WI; School of Pharmacy, University of Wisconsin-Madison, Madison, WI WP 566 An Untargeted Metabolomics Approach for Determining Biomarkers Involved in Spontaneous Pre-Term Birth (sp-ptb) Delivery, using a Label-Free LC-DIA-MS Approach; Shirish Yakkundi ; Lee Gethings ; James Langridge ; Louise Kenny, 4 ; Cork University Maternity Hospital, Cork; Waters, Wilmslow, UK; Cork University Maternity Hospital, Cork, Ireland; 4 University College Cork, Cork, Ireland WP 567 Global Metabolomics and Lipidomics of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis in Human Plasma by LC-HRMS; Allison J Levy ; Rainey E Patterson ; Jeremy P Koelmel ; Srilaxmi Kalavalapalli ; Nishanth Sunny ; Fernando Brill ; Kenneth Cusi ; Timothy J Garrett ; Richard A Yost, ; Chemistry Department, University of Florida, Gainesville, FL; Department of Medicine, University of Florida, Gainesville, FL; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL WP 568 Comparative Evaluation of Open Access Software used in Liquid Chromatography-Mass Spectrometry Based Untargeted Metabolomics; Stephanie Samra ; Benjamin Wancewicz ; Brian DeFelice ; Oliver Fiehn ; UC Davis, Davis, CA WP 569 IMS-DIA-MS Characterisation and IMS-MRM QconCAT Quantitation of the Lipidome and Apolipoprotein Complements of Obesity and Diabetes Cohorts; Lee A Gethings ; Johannes PC Vissers ; Jose Castro-Perez ; Yvonne Woolerton ; Lynn McLean ; Robert Beynon ; James I Langridge ; Waters, Wilmslow, UK; Waters Corp., Milford, MA; Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, Liverpool, UK WP 570 Evaluation of Ion Mobility/ TOF Mass Spectrometry with Multiple LC Method Parameters for Enhanced Detectionin Metabolic Profiling; Paul Rainville ; David Heywood ; Langridge James ; Robert Plumb ; Jose Castro- Perez ; Waters, Milford, MA; Waters, Manchester, UK WP 57 Profiling the Gut Microbiota Metabolome using HPLC coupled to Ion Mobility-Mass Spectrometry to Study Obesity; James Poland ; Alexandra C Schrimpe-Rutledge ; Charles Robb Flynn ; John A McLean ; Vanderbilt Dept. of Chemistry, Nashville, TN; Vanderbilt University, Nashville TN USA Nashville, TN WP 57 Identification of Eicosanoids Mediating Thromboresistance using an Untargeted Metabolomics and Informatics Approach; Patrizia B Stadler ; Shunyan Mo ; Phillip Seitzer ; Christopher M Colangelo ; Jeffrey J Rade ; Scott A Shaffer ; University of Massachusetts Medical School, Worcester, MA; Proteome Software, Portland, OR; Primary Ion, Old Lyme, CT WP 57 Untargeted Profiling using GC-QTOF MS and Parallel EI and CI analysis to Identify Biomarker Panels to Stratify Patients for Treatment; Robert Trengove,, ; Tom Dignan, 4 ; Ben Hunter, 4 ; Garth Maker, 4 ; Hayley Abbiss, 4 ; Joel Gummer,, 4 ; Murdoch University, Murdoch, WA; Separation Science and Metabolomics Laboratory, Perth, Australia; Metabolomics Australia, WA Node, Murdoch, Australia; 4 School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia WP 574 Metabolomic Analysis of Melanoma Skin Tissues by Liquid Chromatography Mass Spectrometry; Matthew Kazaleh ; Candice Ulmer ; Louis Searcy ; Michael Costanzo ; Nikolaus Gravenstein ; Richard A Yost ; University of Florida, Gainesville, FL Nanoscale and Microfluidic Separations and MS WP 575 Segmented Flow Sampling with Push-Pull Theta Pipettes for Electrospray Ionization Mass Spectrometry; Anumita Saha-Shah ; Curtis M Green ; David H Abraham ; Lane A Baker ; Indiana University Dept. Chemistry, Bloomington, IN WP 576 Development of a Microfluidic Platform for High Throughput Validation of Candidate Disease Biomarkers; I-Hsuan Chen ; Ning Bao ; Weiguo Andy Tao ; Purdue University, West Lafayette, IN; Nantong University, Nantong, China WP 577 Ionic Liquid Matrices for MALDI Analysis and CE Separation; Leila Josefsson ; Johan Jacksen ; Åsa Emmer ; KTH Royal Institute of Technology, Stockholm, Sweden WP 578 Sensitivity Gains using Microflow LC/MS for Oligonucleotide Analysis; Michael Donegan ; James P Murphy ; Waters, Milford, MA WP 579 Study of Ionization Efficiency on Silicon-Based, Micro- Fabricated Electrospray Nozzles for Micro Flow LC- ESI-MS applications; Christine Wang ; Simon J Prosser ; Jamey Jones ; Daniel Eikel ; Advion, Inc. Ithaca, NY WP 580 Decreasing Cycle Time While Maintaining Analytical Sensitivity in Microflow LC/MS utilizing a Novel Valve Switching Algorithm; Jay S. Johnson ; James P Murphy ; Water Corporation, Milford, MA; Waters Corporation, Milford, MA WP 58 Post-column Addition as a Tool to Enhance Performance in Microflow LC/MS; Angela Doneanu ; Catherine Tremblay ; Michael P Donegan ; James P Murphy ; Waters, Milford, MA WP 58 Increasing Operable Flow Range of a Nano-spray Source for High-Performance Microspray on a Curtain Gas Equipped Triple Quadrupole API-MS; Amanda Berg ; Helena Svobodova ; Gary A Valaskovic ; New Objective, Inc., Woburn, MA; New Objective, Woburn, MA WP 58 Picodroplet Mass Spectrometry for Miniaturized High Throughput Analysis of Synthetic Biology Clones; Xin Li ; Murray J Brown ; Clive A Smith ; Gareth R Cooper ; Xin Liu ; Anthony Dossang ; Marian Rehak ; Angela Bridges ; Vinayaka Pawate ; Bill J Leavens ; Sphere Fluidics Limited, The Jonas Webb Building, Babraham Research Campus, Cambridge, UK; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK WP 584 High-throughput Enzymatic Characterization by Integration of Nanostructure-Initiator Mass Spectrometry and Droplet to Digital (DD) Microfluidics; Joshua Vance Heinemann ; Kai Deng, ; Steve C.C. Shih ; Jian Gao ; Markus de Raad ; Benjamin P Bowen, ; Paul D Adams, ; Anup K. Singh, ; Trent Northen, ; Lawrence Berkeley Nat l Lab, Berkeley, CA; Sandia National Laboratories, Albuquerque, NM; Joint BioEnergy Institute, Emeryville, CA WP 585 A Novel Targeted Metabolic Profiling Workflow for Simultaneous Reverse Phase and HILIC microflow LC-MS/MS Analysis; Daniel M Warren ; Jeffery D Miller ; SCIEX, Redwood City, CA WP 586 An Affordable and Simple-To-Use Snap-Chip-iMALDI Technology for Measuring Plasma Rennin Activity; Huiyan Li,, ; Arya Tavakoli, ; Robert Popp ; Christoph H. Borchers 4, 5 ; David Juncker, ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; Biomedical Engineering Department, McGill University, Montreal, QC, Canada; McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada; 4 University of Victoria - Genome BC Proteomics Centre, Victoria, BC; 5 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

155 WEDNESDAY POSTERS Plant omics WP 587 Quantitative Analysis of Crosslinked Protein Complexes: A Novel Interactome Approach to Assess Pathogen-Triggered Unconventional Secretion in Arabidopsis; Tricia Ho ; Kevin Blackburn ; John D Williamson ; Michael B Goshe ; North Carolina State University, Raleigh, NC WP 588 Identification of Direct Substrates of MAP Kinases Activated by Environmental Stresses in Arabidopsis Thaliana through Protein Kinase Assay Linked- Phosphoproteomics; Chuan-Chih Hsu ; Pengcheng Wang ; Chunzhao Zhao ; Jian-kang Zhu ; Weiguo Andy Tao ; Purdue University, West Lafayatte, IN; Purdue University, West Lafayette, IN WP 589 Chloroplast Protein Maturation, Regulation and Degradation; Elden E. Rowland ; Jitae Kim ; Klaas J. van Wijk ; Cornell University, Ithaca, NY WP 590 Emerging Role of Sirtuins and Lysine Acylation in the Regulation of Plant Metabolism; Dana M Freund ; Jerry D Cohen ; Adrian D. Hegeman ; University of Minnesota at Twin Cities, Saint Paul, MN WP 59 Label-free Quantitative Mass Spectrometry-Based Proteomic Approach for Comprehensive Analysis of Protein Complexes and Protein-Protein Interactions in Plants; Uma Aryal ; Zachary McBride ; Donglai Chen ; Jun Xie ; Daniel Szymanski ; Purdue Proteomics Facility, Bindley Bioscience Center, West Lafayette, IN; Purdue University, West Lafayette, IN WP 59 Plant Proteomes Aplenty: Quantitative and Phylogenetic Analysis of Five Angiosperms, a Gymnosperm and a Bryophyte; Harald Marx ; Alicia L Richards ; Dhileepkumar Jayaraman ; Jean-Michel Ané ; Joshua J Coon ; University of Wisconsin-Madison, Madison, WI WP 59 Investigating the Expressed Kinome in C. reinhardtii; Emily Werth ; T.S. Karim Gilbert ; Lee M Graves ; Leslie M Hicks ; UNC Chapel Hill, Department of Chemistry Chapel Hill, NC; UNC Chapel Hill, School of Medicine Chapel Hill, NC WP 594 Quantitative Proteomics of Phaeodactylum tricornutuminphosphate Limited Environment; Shiang- Yu Tsai ; Pang-Hung Hsu ; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan WP 595 UHPLC-HRMS Analysis of Herbal Plant Extracts to Screen for Small Molecule Drugs with Antibacterial Activity; Gaganpreet Monga ; Anima Ghosal ; Dil Ramanathan ; Kean University, Union, NJ WP 596 Comparative Protein Analysis of Oil Palm Mesocarp from Elaeis Guineensis and Elaeis oleifera to Investigate Acidification Process.; Jessica K. A. Macêdo ; Jorge C. Rodrigues-Neto, ; Jéssica S. Barros, ; Letícia Jungmann ; Patrícia Verardi Abdelnur 4 ; Embrapa Agroenergy, Brasilia, Brazil; Federal University of Goiás, Goiânia, Brazil; University of Brasília, Brasília, Brazil; 4 Embrapa Agroenergy, Brasilia, DF WP 597 MALDI-Mass Spectrometric Imaging of Endogenous Peptides and Proteins in Medicago truncatula; Caitlin Keller ; Erin Gemperline ; Junko Maeda ; Dhileepkumar Jayaraman ; Michael R Sussman ; Jean-Michel Ané ; Lingjun Li ; University of Wisconsin-Madison, Madison, WI WP 598 itraq 8-plex Labeling-Based Proteomics Analysis Reveals Difference of Protein Expression from Sorghum Root which was Treated by Aluminum; Yong Yang; USDA-ARS at Cornell University, Ithaca, NY WP 599 Extracellular Proteomic Response of Thermally Stressed Symbiodinium: Implications for Symbiosis Breakdown during Bleaching; Contessa Ricci ; Bren Ledbetter ; Tam Nguyen ; Saiful M Chowdhury ; Laura Mydlarz ; University of Texas at Arlington, Arlington, TX WP 600 Deep Proteome Analysis of Gerontoplasts from the Inner Integument of Developing Seeds of Jatropha curcas; Mohibullah Shah ; Emanoella L. Soares ; Magda alberto fernandez lima ; Camila B. Pinheiro ; Arlete A. Soares ; Gilberto B Domont ; Fabio CS Nogueira ; Francisco A. P. Campos ; Federal University of Ceará, Fortaleza, Brazil; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; UFRJ, Rio de Janeiro, Rio de Janeiro WP 60 Quantitative Proteomics of Phaeodactylum tricornutumin Acidified Environment; Tai-Yi Jiang ; Pang- Hung Hsu ; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan WP 60 Standard-flow UHPLC Coupled with TripleQuad MS is a Versatile Platform for Both Targeted Metabolomics and Proteomics; Daniel Vik ; Meike Burow ; Barbara Ann Halkier ; University of Copenhagen, Frederiksberg C, Denmark; University of Copenhagen, Copenhagen, Denmark WP 60 Stable Isotopic Labeling of Intact Plants for Molecular Turnover Measurement by HRMS: New Labeling Apparatus and Data Processing Approaches; Calvin P Peters ; Dana M Freund ; Aaron K Rendahl ; Jerry D Cohen ; Adrian D. Hegeman ; University of Minnesota at Twin Cities, Saint Paul, MN WP 604 Multi-OMICs Investigation of the Lignin Deposition Altering Enzyme Family of Arogenate Dehydratases in Arabidopsis and Poplar Tree; Kim K. Hixson; Washington State University, Richland, WA WP 605 Qualification and Quantification of Cannabinoids and Terpenes in Extracts of Cannabis sativaby Gas Chromatography Mass Spectrometry; Allegra Leghissa ; Zacariah L. Hildenbrand ; Sean Jun ; Aaron L Hicks ; Kevin A Schug ; The University of Texas at Arlington, Arlington, TX; Inform Environmental, LLC, Dallas, TX; C4 Laboratories, LLC, Mesa, AZ WP 606 Systemic Defense Induction and Post-Ingestive Rearrangement of Plant Toxins in Insects a Metabolomics Approach Driven by Automated Compound Identification; Sven Heiling ; Aiko Barsch ; Heiko Neuweger ; Emmanuel Gaquerel 4 ; Ian T Baldwin 5 ; Max-Planck-Society, Jena, Thüringen; Bruker Daltonics Ltd, Bremen, DE; Bruker Daltonics Ltd, Bremen, Germany; 4 Centre for Organismal Studies Heidelberg, Heidelberg, DE; 5 Max Planck Institute for Chemical Ecology, Jena, DE WP 607 Metabolic Profiling of Stilbenes by LC-MS for Genetic Analysis in an F Interspecific Grapevine Hybrid Family; Soon Li Teh ; Bety Rostandy ; Mani Awale ; Shanshan Yang ; Jonathan Fresnedo-Ramírez ; Qi Sun ; Matthew D. Clark ; Anne Y. Fennell ; James J. Luby ; Adrian D. Hegeman ; University of Minnesota at Twin Cities, Saint Paul, MN; South Dakota State University, Brookings, SD; Cornell University, Ithaca, NY WP 608 Comprehensive Analysis of Tropical Flower Secondary Metabolites; Elena Stashenko; Universidad Industrial de Santander, Bucaramanga, Santander, Colombia WP 609 Accounting for Complexity: A Procedure for the Targeted Analysis Of Primary- and Secondary- Metabolites, and Phytohormones from a Single Plant Extract; Martin Schäfer ; Christoph Brütting ; Mario Kallenbach ; Gordon van t Slot ; Paul Speir ; Ian T Baldwin ; Max Planck Institute for Chemical Ecology, Department of Molecular Ecology, Jena, Germany; Bruker Daltonik GmbH, Bremen, Germany; Bruker Daltonics, Inc., Billerica, MA WP 60 Depth Profiling of Whole Soybean Nodules using Laser Ablation Electrospray Ionization Mass Spectrometry; Christopher Anderton ; Sylwia A Stopka ; Beverly J Agtuca ; Rosalie K Chu ; David W Koppenaal ; Gary Stacey ; Akos Vertes ; Ljiljana Pasa-Tolic ; Pacific Northwest National Laboratory, Richland, WA; George Washington University, Washington DC; University of Missouri, Columbia, MO 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 55

156 GENERAL WEDNESDAY INFORMATION POSTERS WP 6 Identificacion of Metabolites Involved in the Color Reversion Process in Blackberry Fruit using LC- ESI-QTOF; Victor Manuel Mondragon Olguin ; Georgina Alejandra Pérez Pérez ; Edmundo M. Mercado Silva ; Gelasio Perez ; Agilent Technologies Mexico, Mexico, DF; Universidad Autonoma de Queretaro, Queretaro, QRO WP 6 REIMS (Rapid Evaporative Ionization Mass Spectrometry) and Multi-Variant Statistics, Two Tools in Support of Weed Grass Speciation and Phenotype Characterization; Sara Stead ; Jackson Pope ; Robert Edwards ; Melissa Brazier-Hicks ; Catherine Tetard-Jones ; Zoltan Takats 4 ; Waters corp, Manchester, Lanc; Waters, Wilmslow, UK; University of Newcastle, Newcastle upon Tyne, UK; 4 Imperial College, London, UK WP 6 DESI-MS Imaging with Ion Mobility and Multivariate Analysis for the Determination of Weed Grass Species and Surface Level Characteristics; Philippa Jayne Hart ; Sara Stead ; Emmanuelle Claude ; Hernando Olivos ; Melissa Brazier-Hicks ; Catherine Tetard-Jones ; Robert Edwards ; Waters Corporation, Wilmslow, UK; Waters Corporation, Beverly, Massachusetts; Newcastle University, Newcastle upon Tyne, UK Protein Therapeutics: Quantitative Analysis WP 64 Method Development of an Automated Hybrid LBA- LC/MS Assay for the Quantitative Bioanalysis of the Biotherapeutic Teriparatide in Human Plasma; Jean- Nicholas Mess ; Daniel Villeneuve ; Georges Koudssi ; Anahita Keyhani ; Algorithme Pharma Inc., Laval, Canada WP 65 Improving the Sensitivity for an Immunocapture LC-MS Assay of Infliximab in Rat Plasma Using Trap-and-Elute MicroLC-MS; Remco van Soest ; Lei Xiong ; SCIEX, Redwood City, CA WP 66 Development and Validation of an LC-MS/MS Method for the Quantitation of Linker-extended Cyanovirin-N in Rat Plasma; Hui Hong ; Wenzhong Liang ; Xin Zhang ; Xinping Fang ; WuXi AppTec (Shanghai) Co. Ltd., Shanghai, China WP 67 Quantitation of Insulin Glargine and Major Metabolites in Human Plasma Using Hybrid LBA-LC/MS with Automated Magnetic Particle Processing; Kevork Mekhssian ; Jean-Nicholas Mess ; Anahita Keyhani ; Algorithme Pharma Inc., Laval, Canada WP 68 Quantitation of a Modified Insulin in Rat Plasma Using Triple Quad 6500 LC-MS/MS; Rong Huang ; Guangchun Zhou ; Joshua Froning ; Yong-Xi Li ; Medpace Bioanalytical Laboratories, Cincinnati, OH WP 69 Automated Biotherapeutic Quantitation from Tissue; Kristin Geddes ; Lisa A Vasicek ; Daniel S Spellman ; Kevin P Bateman ; Merck and Co, Inc, West Point, PA; Merck & Co., Inc., West Point, PA WP 60 Quantitative Bioanalysis of Rituximab and Reditux for Biosimilarity Assessment Comparing Triple Quadrupole and Hybrid Time-of-Flight Platforms; Richard Lavallée ; Daniel Villeneuve ; Kevork Mekhssian ; Jean-Nicholas Mess ; Anahita Keyhani ; Algorithme Pharma Inc., Laval, Canada WP 6 Using a Tandem Protein Precipitation/Immunoaffinity Purification Extraction to Resolve Specificity and Sensitivity Roadblocks: Bioanalysis of a PEGylated Human Protein Analog; Jonathan R St-Germain ; Luca Genovesi ; Jean-Nicholas Mess ; Anthony T Murphy ; Selina Estwick ; Patricia L Brown-Augsburger ; Anahita Keyhani ; Algorithme Pharma Inc., Laval, Canada; Eli Lilly and Company, Indianapolis, IN WP 6 Comparison of Bottom-Up and Top-Down Analytical Methodologies for the Quantitative Bioanalysis of Large Therapeutic Peptides in Biological Matrix; Georges Koudssi ; Jean-Nicholas Mess ; Anahita Keyhani ; Algorithme Pharma Inc., Laval, Canada WP 6 Generic Quantitative LC-MS/MS Assay for Analysis of higg Based Therapeutic Proteins in Cynomolgus Monkey Serum Using Immunocapture with MSIA - D.A.R.T. S ; Christian Lanshoeft, ; Olivier Heudi ; Sarah Cianférani ; Eric E Niederkofler ; Ravindra Chaudhari ; Andrew Paul Warren ; Franck Picard ; Olivier Kretz ; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland; Université de Strasbourg, Laboratoire de Spectrométrie de Masse BioOrganique, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France; Thermo Fisher Scientific, Tempe, AZ WP 64 Applying Rapid Trypsin Digestion for Targeted Protein Quantitation in Rat Plasma by Liquid Chromatography/ Tandem Mass Spectrometry; Moucun Yuan ; Morse Faria ; Jinlin Shen ; Song Zhao ; Eric Ma ; Elizabeth Dompkowski ; Michael Waldron ; Bruce Hidy ; William R. Mylott Jr. ; Rand Jenkins ; PPD, Richmond, VA WP 65 Absolute Quantitation of Glycan and Site-Specific Glycoforms on Commercial mabs using Multiple Reaction Monitoring; Nari Seo ; Unyong Kim ; Hyun Joo An ; GRAST&AGRS, Chungnam National University, Daejeon, Republic of Korea; Asia-Pacific Glycomics Reference Site (AGRS), Daejeon, Republic of Korea WP 66 Improved Reagents and Software for Comparing Biosimilar and Originator Therapeutic Proteins: Accurate Analysis of Deamidation and Disulfide Bond Scrambling; Wilfred H Tang ; Marshall Bern ; John St Skilton ; Eric Carlson ; Michael J Ford ; Karthik Pisupati ; Anna Schwendeman ; Chris Hosfield 4 ; Sergei Saveliev 4 ; Michael M Rosenblatt 4 ; Marjeta Urh 4 ; Chris Becker ; Protein Metrics Inc., San Carlos, CA; MS Bioworks, LLC Ann Arbor, MI; University of Michigan, Ann Arbor, MI; 4 Promega Corp, Madison, WI WP 67 The Use of Generic Surrogate Peptides for the Quantitative Analysis of higg in Pre-Clinical Species with High-Resolution Mass Spectrometry; Christian Lanshoeft, ; Thierry Wolf ; Olivier Heudi ; Sarah Cianférani ; Samuel Barteau ; Markus Walles ; Kelly B Doering ; Guillaume Bechade 4 ; Franck Picard ; Olivier Kretz ; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland; Université de Strasbourg, Laboratoire de Spectrométrie de Masse BioOrganique, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France; Waters, Milford, MA; 4 Waters AG, Baden-Daettwil, Switzerland WP 68 Host Cell Protein Analysis by microflow-lc High Resolution SWATH-MS of Vaccine Samples under Development; Søren Heissel ; Milla Neffling ; Rikke Raaen Lund ; Thomas Kofoed ; Marie Grimstrup ; Nick Morrice ; Anne Fich Holmbjerg 4 ; Max Per Kristiansen 4 ; Ingrid Kromann 4 ; Peter Højrup ; Ejvind Mørtz ; Department of Biochemistry and Molecular Biology, University of Southern Denmark Odense, Denmark; SCIEX, Phoenix House Lakeside Drive Warrington Cheshire UK; Alphalyse A/S, Odense M, DK; 4 Statens Serum Institut, Copenhagen, Denmark WP 69 Highly Sensitivity and Reproducible MRM Based Quantitation of Follicle Stimulating Hormones (FSH) in Human Plasma using QTRAPTM 6500; Faraz Rashid ; Rahul Baghla ; Prashant Kale ; Manoj Shukla ; Milin Shah ; Dipankar Malakar ; Anoop Kumar ; Manoj Pillai ; SCIEX, Udyog Vihar Phase IV Gurgaon, India; Sciex Gurgaon, Gurgaon, India; Lambda Therapeutic Research Ltd, Ahmedabad, India PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

157 WEDNESDAY POSTERS WP 60 Streamlining the Complete Sequence Variant Analysis Workflow for Biotherapeutics; Andrew Dawdy ; Michelle English ; Mellisa Ly ; Andrew Saati ; Lisa A Marzilli ; Olga Friese ; Jason C Rouse ; Yong J Kil ; Marshall Bern ; Eric Carlson ; Chris Becker ; Pfizer, Inc. Chesterfield, MO; Pfizer, Inc. Andover, MA; Protein Metrics Inc., San Carlos, CA WP 6 Comparison of First Dimension Fractionation Strategies for Directed MS Analysis of Host Cell Proteins; Jordy Hsiao ; Te-Wei Chu ; Gregory O Staples ; Oscar Potter ; Hongfeng Yin ; Kevin Killeen ; Agilent Technologies, Santa Clara, CA WP 6 Determination of Total Recombinant Human α-galactosidase A in Plasma Samples by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/ MS); Rick Hamler ; Kees Bronsema ; Peter Pruim ; Peter Bults ; Deborah Hilliard ; Russell Gotschall ; Franklin K Johnson ; Hung Do ; Kenneth Valenzano ; Nico van de Merbel ; Elfrida R Benjamin ; Amicus Therapeutics, Cranbury, NJ; PRA Health Sciences, Assen, The Netherlands WP 6 Herceptin Quantitation Using Universal and Signature Peptides by Hybrid LBA/LC-MS Method; XI QIU ; Daniell Rowles ; Susan Zondlo ; John Kolman ; Zamas Lam ; QPS, Newark, DE WP 64 Quantitative Analysis of Adalimumab using nano- Surface and Molecular-Orientation Limited (nsmol) proteolysis and LC/MS/MS; Deepti Bhandarkar ; Ravi Krovidi ; Rashi Kochhar ; Shailendra Rane ; Shailesh Damale ; Purushottam Sutar ; Anant Lohar ; Ashutosh Shelar ; Jitendra Kelkar ; Ajit Datar ; Pratap Rasam ; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, India; Lambda Therapeutic Research, Ahmedabad, India WP 65 SSPaQ: A Subtractive Method for the Parallel Quantification of the Degree of Modification at Every Possible Site of a Protein; Guillaume Gabant ; Alain Boyer ; Martine Cadene ; CBM CNRS UPR40, Orleans, France WP 66 Quantification of the Antibody Drug Conjugate, Trastuzumab Emtansine and the Monocolonal Antibody, Trastuzumab in Plasma Using a Generic Kit-Based Approach; Hua Yang ; Mary E Lame ; Erin E Chambers ; Sherri Naughton ; Waters Technologies Corporation, Milford, MA WP 67 Applying a Standardized, Kit-based Approach to Achieve 0 ng/ml Infliximab from 5 µl Plasma; Mary E Lame ; Hua Yang ; Erin E Chambers ; Sherri Naughton ; Waters, Milford, MA WP 68 Quantification of Host Cell Proteins in Biotherapeutics using Stable Isotope Labeled Chinese Hamster Ovary Proteins (SIL-CHOP) as an Internal Standard; Pegah R Jalili ; Zhiyun Cao ; Kevin Ray ; Rong-Rong Zhu ; MilliporeSigma, Saint Louis, MO; MilliporeSigma, Bedford, MA WP 69 Host Cell Protein Analysis of Biopharmaceuticals using Automatic Offline Fractionation and LC/MS; Alex Zhu ; Jing Chen ; Steve Murphy ; Jordy Hsiao ; Agilent Technologies, Wilmington, DE; Agilent Technologies, Inc. Madison, WI; Agilent Technologies, Santa Clara, CA WP 640 Exploiting His-tags in Recombinant Protein Therapeutics to Introduce Metal Tracers for Tracking Biodistribution of Biopharmaceuticals in vivo; Chengfeng Ren ; Grégoire Bonvin ; Cedric Bobst ; Igor A Kaltashov ; University of Massachusetts Amherst, Amherst, Massachusetts WP 64 Analysis of N-Glycans Released from Monoclonal Antibodies using an ESI-MS-friendly Fluorescent Tag; Oscar Potter ; Gregory O Staples ; Hongfeng Yin ; Kevin Killeen ; Agilent Technologies, Santa Clara, CA WP 64 Evaluation of Transferrin Metal Tracers using Native ESI-MS and in-vitro Model for Tracking Its Biodistribution with ICP-MS.; Grégoire Bonvin ; Cedric Bobst ; Igor A Kaltashov ; University of Massachusetts Amherst, Amherst, Massachusetts; University of Massachusetts-Amherst, Amherst, Massachusetts WP 64 Comprehensive HCP Profiling by Targeted and Untargeted Analysis of DIA Mass Spectrometry Data with PRM qualification; Simion Kreimer ; Yuanwei Gao ; Mi Jin ; Nesredin Mussa ; Alexander R. Ivanov ; Barry L. Karger ; Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA; Bristol-Myers Squibb, Devens, MA WP 644 A Promising Alternative to SRM-Very-high-resolution selected-ion- Monitoring (vhr-sim@500k) Enables Ultra-sensitive and Selective Biotherapeutics Quantification; Yang Qu ; Bo An ; Ming Zhang; Xiaomeng Shen; Shichen Shen; Jun Li; Jun Qu; SUNY at Buffalo, Buffalo, NY WP 645 Significant Throughput Increase in Peptide Mapping/ MAM Analysis Using D-UPLC; Cong Wu ; Hai Yue ; Sabrina Benchaar ; Amgen, Inc., Thousand Oaks, CA WP 646 Sulfur-based Characterization of Protein Standards using Isotope Dilution Inductively Coupled Plasma Mass Spectrometry; Hyun-Seok Lee, ; Sook Heun Kim ; Ji-Seon Jeong, ; Yong-Moon Lee ; Yong-Hyeon Yim, ; KRISS, Daejeon, Republic of Korea; College of Pharmacy, Chungbuk National University, Cheongju, Korea; Department of Analytical Sciences for Biology, University of Science and Technology (UST), Daejeon, Korea WP 647 Bioanalysis of Radiolabeled Payload by Isotopic Pattern Deconvolution and LC-MS/MS to Investigate Tissue Distribution of Protein Drug Conjugates; Weiqi Chen ; Wenying Li ; Jinping Gan ; Bristol-Myers Squibb Co., Princeton, NJ WP 648 Site-Specific Glycosylation Quantitation of Bioengineered Recombinant Therapeutical Glycoproteins; Muchena J. Kailemia ; Wanghui Wei ; Kalimuthu Karuppanan ; Jasmine M. Corbin ; Yanhong Li ; L My Phu ; Abhaya Dandekar ; Xi Chen ; Somen Nandi ; Karen McDonald ; Carlito Lebrilla ; University of California, Davis, Davis, CA WP 649 Large-scale and Ultra-Sensitive Investigation of Biotherapeutics by A Novel Antibody-Free, Dual- Mechanism Enrichment Strategy; Ming Zhang ; Bo An ; Yang Qu ; Shichen Shen ; Jun Qu ; SUNY at Buffalo, Buffalo, NY WP 650 Novel Sample Treatment and LC/MS Strategies Achieved Highly Accurate and Sensitive Investigation of Tissue Distributions of Therapeutic; Wei Fu ; Bo An ; Ming Zhang ; Yang Qu ; Jun Qu; SUNY at Buffalo, Buffalo, NY Proteomics: New Approaches (Global) WP 65 ProteomeTools: Large Libraries of Synthetic Peptides, Spectra and Software for Facilitating Human Proteome Research; Daniel Paul Zolg ; Mathias Wilhelm ; Peng Yu ; Karsten Schnatbaum ; Johannes Zerweck ; Tobias Knaute ; Ulf Reimer ; Holger Wenschuh ; Bernard Delanghe ; Thomas Moehring ; Andreas Huhmer 4 ; Gina Tan 4 ; Mohammed Abujarour 5 ; Siegfried Gessulat 5 ; Stephan Aiche 5 ; Hans-Christian Ehrlich 5 ; Bernhard Kuster, 6 ; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany; JPT Peptide Technologies GmbH, Berlin, Germany; Thermo Fisher Scientific, Bremen, DE; 4 Thermo Fisher Scientific, San Jose, CA; 5 SAP SE, Innovation Center Potsdam Potsdam, Germany; 6 Bavarian Biomolecular Mass Spectrometry Center, Technical University of Munich, Freising, Germany 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 57

158 GENERAL WEDNESDAY INFORMATION POSTERS WP 65 Comprehensive Draft of the HeLa Proteome to a Depth of More than,000 Proteins; Christian Dahl Kelstrup ; Dorte B Bekker-Jensen ; Tanveer S Batth ; Sara C Larsen ; Michael L Nielsen ; Jesper V Olsen ; CPR, University of Copenhagen, Copenhagen, Denmark WP 65 Subtilisin for Large Scale (phospho)proteomcis the Beginning of a Wonderful Love Story?; Humberto Gonczarowska-Jorge, ; Stefan Loroch ; Margherita Dell Aica ; René Zahedi ; ISAS, Dortmund, Germany; CAPES Foundation, MinistryofEducationofBrazil Brasília- Brazil; ISAS, Dortmund WP 654 A New Approach to the Analysis of Intact Major Urinary Proteins (MUPs) from Mouse Urine by CESI-MS; Stephen J. Lock ; Robert J. Beynon ; Guadalupe Gomez- Baena ; Edna Betgovargez ; SCIEX, Warrington, Cheshire; Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, Liverpool, UK; SCIEX, Concord ON, Canada WP 655 Proteogenomics of HEK9 Cell Line: Identification of Variant Peptides using Deep Proteome Data from the Inter-Laboratory Studies; Anna Lobas, ; Dmitry Karpov,4 ; Arthur Kopylov ; Elizaveta Solovyeva, ; Mark Ivanov, ; Irina Ilina ; Vassily Lazarev 5 ; Ksenia Kuznetsova ; Ekaterina Ilgisonis ; Victor Zgoda ; Mikhail V Gorshkov, ; Sergei Moshkovskii ; Institute for Energy Problems of Chemical Physics, Moscow, Russian Federation; Moscow Institute of Physics and Technology, Dolgoprudny Moscow Oblast, Russia; Institute of Biomedical Chemistry, Moscow, Russia; 4 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; 5 Research Institute of Physico-Chemical Medicine, Federal Medico-Biological Agency, Moscow, Russia WP 656 Novel Approaches in de novo Peptide Sequencing and Proteogenomics as Tools to Explore Uncharted Organisms; Bernhard Blank-Landeshammer ; Karsten Biß ; Laxmikanth Kollipara ; Vera Rieder ; Marleen Stuhr ; Tilman Schell 4 ; René P Zahedi ; Markus Pfenninger 4 ; Jörg Rahnenführer ; Hildegard Westphal ; Albert Sickmann ; Leibniz-Institut für Analytische Wissenschaften, Dortmund, Germany; Fakultät Statistik, Technische Universität Dortmund, Dortmund, Germany; Leibniz Center for Tropical Marine Ecology (ZMT), Bremen, Germany; 4 Biodiversity and Climate Research Centre (BiK-F), Frankfurt Am Main, Germany WP 657 Proteomic Study of Rhizopus Microsporus Fungus Growing in Presence of Copper; Meriellen Dias ; Lidiane Maria de Andrade ; Enrique Eduardo Rozas ; Mariana de Paula Eduardo ; Maria Anita Mendes ; University of São Paulo, São Paulo, SP WP 658 Identification of Methylation and Phosphorylation in Arginine/Serine-Rich Domains by Electron Transfer Dissociation Mass Spectrometry; Isaac Bishof ; Duc M. Duong ; Eric B. Dammer ; Nicholas T. Seyfried ; Emory University, Atlanta, GA; Emory University School of Medicine, Atlanta, GA WP 659 Capturing Protein Binders to Yeast Ribosome Biogenesis and Stress Response Genes Using Multiplexed HyCCAPP; Yunxiang Dai ; Julia Kennedy- Darling ; Mark Scalf ; Audrey Gasch ; Lloyd M Smith ; University of Wisconsin-Madison, Madison, WI WP 660 Elucidation of Dynamic Cell Surface Protein-Protein Interactions using Chemoproteomic Technologies; Damaris Bausch-Fluck ; Maria P Pavlou ; Bernd Wollscheid ; Institute of Molecular Systems Biology, Dep. of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland WP 66 Development of an On-Slide-Digestion, MS Assay from Formalin-Fixed Paraffin Embedded (FFPE) Breast Tissue; Ten-Yang Yen ; Moe Thein ; Roger Yen ; Leslie Timpe ; Bruce Macher ; San Francisco State University, San Francisco, CA; San Francisco State University, San Francisco, CA WP 66 Multi-omics Analysis for the Global Proteins and Metabolites in Experimental Autoimmune Myocarditis Rat Model; Jin Woo Jung ; Jae Hun Jung ; Kwang Pyo Kim ; Geum-Sook Hwang ; Jungju Seo ; Korea Basic Science Institute, Deajeon, Republic of Korea; Kyung Hee University, Yongin, Republic of Korea; Korea Basic Science Institute, Seoul, Republic of Korea WP 66 Multiplexing Targeted Proteomics: Increased Throughput of Targeted Biomarker Measurements using Isobaric Labels and Dedicated MS Analysis; Robert Everley ; Brian K. Erickson ; Christopher M. Rose ; Steven P Gygi ; Harvard Medical School, Boston, MA WP 664 Comparative Study on Chemical Derivatization of Lysines to mimic Arg-C digestion; Vahid Golghalyani ; Michael Karas ; Goethe University, Frankfurt Am Main, Germany WP 665 Developing an LC/MS/MS Method for the Identification of Key Secretome Proteins from Human Lung Spheroid Cells; Dipti Paudel ; Phuong-Uyen Dinh ; Jhon Cores ; Robert Kevin Blackburn ; Ke Cheng ; Michael Goshe ; NCSU, Raleigh, NC; North Carolina State University, Raleigh, NC; North Carolina State University, Raleigh, NC WP 666 Evaluation and Establishment of the Method for the Accurate Protein Quantification in the Subcellular Fraction; Atsushi Sakamoto ; Akiko Matsui ; Asami Saito ; Gaku Morinaga ; Akiko Takamoto ; Naoki Ishiguro ; Shinobu Suzuki ; Nippon Boehringer Ingelheim, KOBE, JPN WP 667 Fluorescence Complementation Mass Spectrometry (FCMS) for Identifying Direct Upstream Kinases; Lingfei Zeng; Department of MCMP, Purdue, West Lafayette, IN WP 668 Protein Analysis Using a Combination of an Online Trypsin Immobilized Enzyme Reactor and CAD/ETD Tandem Mass Spectrometry; Kun Cho ; Sang Eun Hong ; Kyung Ju Jang ; Kuk Ro Yoon ; Jong Shin Yoo ; KBSI, Cheongju-Si, S. Korea; Hannam University, Daejeon, Korea WP 669 Parrallel SUMO/Ubi Profiling Using an Optimized Peptide IP; Frederic Lamoliatte ; Francis McManus ; Ghizlane Maarifi ; Mounira K. Chelbi-Alix ; Pierre Thibault ; IRIC-Université de Montréal, Montréal, QC; INSERM Unité Mixte de Recherche S 4, Université Paris Descartes, Paris, France WP 670 Electron-Transfer/Higher-Energy Collision Dissociation (EThcD) Improves Spectral Quality while Retaining Quantitation Accuracy in Isobaric Tag-based Quantitative Proteomic Studies; Yu Feng ; Qing Yu ; Lingjun Li ; University of Wisconsin-Madison, Madison, WI WP 67 A New Digestion Method to Analyze Respiratory Complex I; Stefan Schoenborn; Department of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany WP 67 The Establishment of Nano Mass Spectrometry Analysis Techniques for the Identification of Lead Ion Effect in Hemoglobin; Ming-Hui Yang ; Yu-Chang Tyan ; Graduate Institute of Medicine, KMU, Kaohsiung, Taiwan; Kaohsiung Medical University, Kaohsiung, Taiwan WP 67 A Quantitative Tunable Digestion Approach Uncovers Novel Acetyl and Methyl Marks on Histones; Chris Adams ; Nora Yucel ; Allis C Chien ; Ryan D Leib ; Stanford University, Stanford, CA; Stanford University, Stanford, CA WP 674 Identification of GHB-binding Proteins by Mass Spectrometry (Chemo)proteomic Analysis of Synaptosomal Membrane Proteins; Ulrike Leurs; University of Copenhagen, Copenhagen, Sjaelland PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

159 WEDNESDAY POSTERS Proteomics: Quantitative (Labeling/Tagging/MS/ Quantitation) WP 675 Development of Dimethyl Pyrimidinyl Ornithines (DiPyrO) as Mass Defect-Based Tags for Quantitative Proteomics; Amanda Rae Buchberger ; Dustin Frost ; Lingjun Li ; University of Wisconsin-Madison, Madison, WI WP 676 Examining ph Specificity of Peptide N-terminal Amine Tagging Reagents for cpilot Analysis; Lindsay Osentoski ; Yaphet Geadion ; Joseph Dudenhoeffer ; Christina King ; Renã A.S. Robinson ; University of Pittsburgh, Pittsburgh, PA WP 677 Application of SuperQuant to Obtain Quantitative Information of the Glioblastoma Proteome; Thiago Verano-Braga ; Vladimir Gorshkov ; Sune Munthe ; Mia Dahl Soerensen ; Bjarne Winther Kristensen ; Frank Kjeldsen ; Department of Biochemistry and Molecular Biology, University of Southern Denmark Odense, Denmark; Odense University Hospital, Odense, DK; BMB, Odense M WP 678 Combining of itraq Labeled Peptides from HPLC Fractions: Where is the Limit for Peptides/Proteins Detected and Quantified?; Trong Khoa Pham ; Kirsty Richards ; Jo Roobol ; Colin Robinson ; Phillip C. Wright ; Department of Chemical and Biological Engineering, The University of Sheffield, Sheffield, UK; School of Biosciences, University of Kent, Canterbury, UK; Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, UK WP 679 Increasing Protein Quantification in 6-plex TMT Experiments; Jane Liu ; Michael Sweredoski ; Sonja Hess ; Pomona College, Claremont, CA; California Institute of Technology, Pasadena, CA WP 680 Evaluation of a Pulsed SILAC-TMT Multiplexing Strategy for Measurement of Proteome Dynamics; Jana Zecha ; Chen Meng ; Mathias Wilhelm ; Susan Klaeger ; Bernhard Kuster, ; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany; Bavarian Biomolecular Mass Spectrometry Center, Technical University of Munich, Freising, Germany WP 68 Extended Mass Range QQQ for Routine Analysis of Large, Low-Charge State Peptide Ions; Linfeng Wu ; Christine A Miller ; Agilent Technologies, Santa Clara, CA WP 68 Pseudo-isobaric Fragment Ions Provide Accurate and Precise Proteome Quantification Results; Yuan Zhou ; Jianhui Liu ; Zhigang Sui ; Lihua Zhang ; Yukui Zhang ; Key Laboratory of Separation Science for Analytical Chemistry; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China WP 68 Investigation of Q-TOF Instruments Advantages for label-free Proteome Analysis; Stephanie Kaspar- Schoenefeld ; Markus Lubeck ; Annette Michalski ; Pierre- Olivier Schmit ; Bruker Daltonik GmbH, Bremen, Germany; Bruker Daltonique S.A., Wissembourg, France WP 684 Stable-isotope Maleic Anhydride Labeling-based Approach for Quantitative Proteomics; Kai Zhang ; Shuzhen Zheng ; Shanshan Tian ; Zhenchang Guo ; Guijin Zhai ; Tianjin Medical University, Tianjin, Tianjin; Nankai university, Tianjin, China; Tianjin Medical University, Tianjin, China WP 685 Intact Protein Quantitation up to a 000-fold Using Protein Universal Pseudo-isobaric Dimethylation; Zhixin Tian ; Houqin Fang ; Kaijie Xiao ; Department of Chemistry, Tongji University, Shanghai, Shanghai WP 686 Evaluation of a Novel Tandem Quadrupole Mass Spectrometer for the Quantitative Analysis of Peptides using a Multi-Point Internal Calibration Method; Billy Molloy ; Donald JL Jones, ; Donald P Cooper 4 ; Johannes PC Vissers 4 ; James I Langridge 4 ; Waters, Wilmslow ; Department of Cancer Studies, University of Leicester, UK, Leicester, UK; Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK, Leicester, UK; 4 Waters, Wilmslow, UK WP 687 Comparison of Label-Free and TMT Quantification for Global Phosphoproteome Analysis of Apoptotic Cells; Emmanuelle Lezan ; Christoph Schmutz ; Simon Josef Ittig ; Erik Ahrné ; Alexander Schmidt ; Biozentrum, University of Basel, Basel, Switzerland WP 688 Examining Proton Transfer and Ion Scattering for Intact Proteins in a Triple Quadrupole Mass Spectrometer; Evelyn H Wang ; Dananjaya Kalu Appulage ; Erin A. McAllister ; Kevin A Schug ; University of Texas at Arlington, Arlington, TX; Shimadzu Scientific Instruments, Columbia, MD WP 689 α- and β-tubulin Isotype Repertoire Quantification by LC-SRM in Blood Platelet and HeLa Cells; Agnes Hovasse ; Magda Magiera ; Catherine Strassel ; Alain Van Dorsselaer 4 ; Carsten Janke ; Francois Lanza ; Christine Schaeffer-Reiss 4 ; Laboratoire de Spectrométrie de Masse BioOrganique, IPHC, UMR778, Centre National de la Recherche Scientifique, Université de Strasbourg, Strasbourg, Alsace; Institut Curie, Orsay, France; UMR_S 949 Inserm, EFS-Alsace, Université de Strasbourg, Strasbourg, France; 4 Laboratoire de Spectrométrie de Masse BioOrganique, IPHC, UMR778, Centre National de la Recherche Scientifique, Université de Strasbourg, Strasbourg, France WP 690 Combination of Ultrasensitive Sample Preparation and NHS-chemistry Enables Sensitive Quantification of Lysine Acetylation and Large Proteome Coverage; Christian Frese ; Özge Karayel ; Jeroen Krijgsveld ; DKFZ German Cancer Reserach Center, Heidelberg, Germany WP 69 Combining Ion Mobility Enhanced DDA and DIA Workflows for Label-Free Quantitative Phosphoproteomics; Ute Distler, ; Pedro Navarro ; Jennifer Hahlbrock ; Kuharev Jörg ; Stefan Tenzer ; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany; Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany WP 69 Comprehensive Relative Quantification of the Cytochromes P450 by micro-lc and SWATH Acquisition and Data Processing using Cloud Computing; Rosalind E. Jenkins ; Sibylle Heidelberger ; Thomas Knapman ; Francesco Brancia ; Neil Kitteringham ; Kevin B Park ; Mark Carfazzo ; MRC Centre for Drug Safety Science, Liverpool, UK; SCIEX, Phoenix House Lakeside Drive Warrington Cheshire UK; Sciex, Redwood Shores, CA WP 69 Interference-free Multiplexed Quantification with Complement Reporter Ions: Technological Advances and Application to Nucleocytoplasmic Partitioning; Martin Wuehr, ; Graeme C McAlister ; Thomas Güttler ; Brian K. Erickson ; Matthew Sonnett ; Ramin R. Rad ; Keisuke Ishihara ; Leonid Peshkin ; Aaron C. Groen ; Marc Presler ; Elizabeth Van Itallie ; Wilhelm Haas 4 ; Timothy J. Mitchison ; Steven P. Gygi ; Marc W. Kirschner ; Princeton University, Princeton, NJ; Harvard Medical School, Boston, MA; Thermo Fisher Scientific, San Jose, CA; 4 Massachusetts General Hospital, Boston, MA WP 694 Veracity or Serendipity? Contradicting Conjectures in Protein Quantification; Russell P Grant ; Christopher M Shuford ; Patricia L Holland ; Laboratory Corporation of America, Burlington, NC WP 695 A New and Easy Approach for End-User Driven Quantification of SIL Peptide Solutions in Targeted Proteomics; Karsten Schnatbaum ; Lars Hornberger ; Johannes Zerweck ; Tobias Knaute ; Lawrence Eckler ; Ulf 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 59

160 GENERAL WEDNESDAY INFORMATION POSTERS Reimer ; Holger Wenschuh ; JPT Peptide Technologies GmbH, Berlin, Germany; JPT Peptide Technologies, Berlin, Germany WP 696 PRM Method Optimization on a Q-Exactive Plus Using a Well-Defined Quantitative Proteomics Standard; Zhiyun Cao ; James J Walters ; Kevin B Ray ; MilliporeSigma, St. Louis, Missouri; MilliporeSigma, St. Louis, MO WP 697 Optimizing Experimental Design for Ultra-deep Discovery Proteomics of Breast Cancer Patient Derived Xenografts with Isobaric Peptide Labeling; Qiang Zhang ; Robert Sprung ; Petra Erdmann-Gilmore ; Yiling Mi ; Rose Connors ; Sherri Davies ; Shunqiang Li ; Reid Townsend ; Washington University School of Medicine, Saint Louis, MO WP 698 Development of Robust, Reproducible, High- Throughput Quantitative Proteomic Assays for Cellulosic Biofuel Applications; Yan Chen ; Leanne Jade G Chan ; Héctor García Martín ; Paul D Adams ; Christopher J Petzold ; Lawrence Berkeley National Laboratory, Berkeley, CA WP 699 Highly Multiplexed MRM-based Peptide Quantitation in Human Plasma Using Two Different Stable Isotope Labeled Peptides for Calibration; André LeBlanc ; Sarah Michaud ; Andrew Percy ; Darryl B Hardie ; Juncong Yang ; Nicholas Sinclair ; Jillaine Proudfoot ; Adam Pistawka ; Derek S Smith ; Christoph H. Borchers, 4 ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; MRM Proteomics, Inc., Victoria, BC, Canada; University of Victoria - Genome BC Proteomics Centre, Victoria, BC; 4 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada WP 700 Second Generation Combinatorial Mass Tag (CMT) Isobaric Reagents with Improved Quantitative Precision; Craig Braun ; Brian Erickson ; Gregory Bird ; Steven P Gygi ; Harvard Medical School, Boston, MA; Dana Farber Cancer Institute, Boston, MA WP 70 Utilizing Synthetic Peptides and Skyline for Validating Quantitative Changes in Bacterial Proteomics; Chia- Fang Lee ; Chen-Hsun Tsai ; Lydia M. Contreras ; Maria D. Person ; University of Texas at Austin, Austin, TX WP 70 A Peptide-Retrieval Strategy Enables Significant Improvement of Quantitative Performance Without Compromising Confidence of Identification; Chengjian Tu ; Shichen Shen ; Quanhu Sheng ; Yu Shyr ; Jun Qu ; University at Buffalo, Buffalo, NY; Vanderbilt University, Nashville, TN WP 70 Multiplexing Quantification of Proteins by Single-Cell CE-µESI-HRMS Finds Translational Cell Heterogeneity in the 6-cell Frog (Xenopus) Embryo; Camille Lombard- Banek ; Sally A Moody ; Peter Nemes ; Sushma Reddy ; The George Washington University, Washington, DC WP 704 Secretome Profiling of Antibody-Producing CHO Cells using Non-Natural Amino Acid Crosslinking Pull Down and Mass Spectrometry; Carlo Martins ; Raghothama Chaerkady ; Michael Bowen ; Deniz Baycin-Hizal ; MedImmune, Gaithersburg, MD Small Molecules: Quantitative Analysis (Part ) WP 705 Dilute and Shoot FI-MS/MS for Quantification of Glycocholic Acid in Human Bile using Standard Addition Method; Raghavi Kakarla ; Ramakrishna reddy Voggu ; Janet R Donaldson ; Baochuan Guo ; Cleveland State University, Cleveland, OH; Mississippi State University, Starkville, MS WP 706 Development of Cost-Effective Liquid Chromatography- Tandem Mass Spectrometry Method for Polar Drugs and Metabolites; Xiaodong Zhu ; Jingguo Hou ; Jerry Gardella ; Melvin Tan ; Tom Lloyd ; Edward Wells ; Worldwide Clinical Trials Drug Development Solution, Austin, TX WP 707 Development and Validation of an Ultra Sensitive and Automated LC-MS/MS Method for the Measurement of Naloxone, Buprenorphine and Norbuprenorphine; Nick Peng ; Ben Gaboury ; Nichole Boice ; Dan Pederson ; Ardeshir ardeshir khakang ; Axis Clinicals, Dilworth, MN WP 708 Development and Validation of a Simple, Rugged and Automated LC-MS/MS Method for the Determination of Mesalamine in Human Plasma; Nick Peng ; BEN GABOURY ; Sarah Maasjo ; Ardeshir Khadang ; Axis Clinicals, Dilworth, MN WP 709 Simultaneous Determination of Tamsulosin and Solifenacin in Human Plasma by Ultra-High Performance Liquid Chromatography with Tandem Mass Spectrometry; Jin Sun Woo ; Hwa Suk Kim ; Seo Hyun Yoon ; Joo-Youn Cho ; Seoul National University College of Medicine, Seoul, South Korea WP 70 Applications of Improved GCMS Method for Fatty Acid Analysis in Samples from Bariatric Patients and Mice Fed Omega- Fatty Acids; Kazimierz Surowiec ; Nadeeja N. Wijayatunga ; Latha Ramalingam ; Valerie G. Sams ; Gregory J. Mancini ; Matthew L. Mancini ; Yehia Mechref ; Naima Moustaid-Moussa ; Texas Tech University, Lubbock, TX; University of Tennessee Medical Center, Knoxville, TN WP 7 A Two-dimensional Liquid Chromatography (D-LC) to Separate an Interference Peak from Norfentanyl for Its Successful Bioanalysis; Moo-Young Kim ; Brendan Laing ; Fumin Li ; PPD, Middleton, WI WP 7 Development and Validation of a LC-MS/MS Method for the Simultaneous Quantitation of Carboplatin and Etoposide in Human Plasma and Ultrafiltrate; Jessica Sima ; Ganesh S Moorthy ; Athena Zuppa ; Elizabeth Fox ; Children s Hospital of Philadelphia, Philadelphia, PA; Children s Hopsital of Philadelphia, Philadelphia, PA WP 7 Highly Accurate Sample Collection, Handling and LCMSMS Bioanalysis of Liposomal Amphotericin B Plasma Samples; Jason Bilodeau ; François Viel ; Nadine Boudreau ; Clark Williard ; inventiv Health, Québec, Canada WP 74 Determination of Unconjugated Naloxone, Conjugated Naloxone and Total Naloxone in Human Plasma by LCMSMS; Louis-Charles Boisvert ; Nicolas Jean ; Guy Havard ; Philippe Belanger ; Marie-Josée Marcoux ; Sylvain Lachance ; Nadine Boudreau ; Clark Williard ; inventiv Health, Québec, Canada WP 75 Trace Level Quantitative Determination of Phthalates from High Risk Dosage Pharmaceutical Formulations using LC/MS/MS; Purushottam Sutar ; Rashi Kochhar ; Deepti Bhandarkar ; Shailendra Rane ; Shailesh Damale ; Anant Lohar ; Ashutosh Shelar ; Jitendra Kelkar ; Pratap Rasam ; Ajit Datar ; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, India WP 76 Highly Sensitive Multiplexed Analysis of Levosalbutamol from Plasma using LC/MS/MS; Ashutosh Shelar ; Shailesh Damale ; Shailendra Rane ; Purushottam Sutar ; Anant Lohar ; Deepti Bhandarkar ; Rashi Kochhar ; Pratap Rasam ; Jitendra Kelkar ; Ajit Datar ; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, India WP 77 Robust, Sensitive and Accurate Determination of Different Opioids in Human Plasma by LCMSMS; Genevieve Emond ; Marc Fournier ; Marie-Claude Théberge ; Nathalie Pelletier ; Marie-Josée Marcoux ; Sylvain Lachance ; Nadine Boudreau ; Clark Williard ; inventiv Health, Québec, Canada WP 78 Simultaneous Assay of Multiple Synthetic Contraceptive Hormones in Human Serum by LCMS- MS; Steven W Blue ; Rachel Lieberman ; David W Erikson ; Christopher Gilles ; Oregon National Primate Research Center, Beaverton, OR; Shimadzu Scientific Instruments, Columbia, MD PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

161 WEDNESDAY POSTERS WP 79 Highly Sensitive Automated Assay for the Determination of Oxytocin in Human Plasma by LC-MS/MS; Nicolas Jean ; Philippe Bélanger ; Carine Lévesque ; Marie-Claude Théberge ; Nadine Boudreau ; Clark Williard ; Hermes Licea-Perez ; Jonathan Kehler ; Thomas Mencken ; inventiv Health, Québec, Canada; GlaxoSmithKline, Upper Merion, PA WP 70 Quantification of Tenofovir and Emtricitabine in Human Plasma using High Throughput LDTD-MS/MS; Jean Lacoursiere ; Annie-Claude Bolduc ; Alex Birsan ; Serge Auger ; Pierre Picard ; Phytronix Technologies, Inc. Quebec, Canada; Université Laval, Québec, Canada WP 7 A Sensitive LC-MS/MS Method for Quantitation of Naltrexone and 6ß-Naltrexol in Human Plasma ( pg/ ml); Dawei Zhou ; Shaoting Zhang ; Mohamed Osman ; Xinping Fang ; WuXi AppTec Co., Plainsboro, NJ WP 7 Quantification of N-Hydroxy Riluzole Metabolite in Human Plasma: The Investigation of the Stability of the Analyte; Luc Bouchard ; Nathalie Pelletier ; Sylvain Lachance ; Nadine Boudreau ; Clark Williard ; inventiv Health, Québec, Canada WP 7 Ultra-Sensitive LCMSMS Determination of Teriparatide in Human Plasma; Philippe Bélanger ; Marie-Josée Marcoux ; Nadine Boudreau ; Clark Williard ; inventiv Health, Québec, Canada WP 74 Development of an Ultrasensitive Assay for Quantification of Free Ticagrelor in Plasma using Equilibrium Dialysis and LC-MS/MS; Ann-Sofie Sandinge ; Annika Janefeldt ; AstraZeneca R&D, Gothenburg, Sweden WP 75 Bioanalytical LC/MS/MS Method for the Determination of a Vitamin E analog in Human Plasma; Jeff Jeppson ; Elizabeth Dibbern ; Ridha Nachi ; Celerion, Lincoln, NE WP 76 Comparison of the Quantitation of Bile Acids using Full Scan and Targeted SIM Mode on using UPLC/HRAM MS; Brandon Wilcock ; Lijuan Fu ; Nan Zhao ; Cassidy Hatch ; Nidhi Jaiswal ; Min Meng ; Troy Voelker ; Scott Reuschel ; Covance, Salt Lake City, UT WP 77 A Selective and Ultra-Sensitive LC-MS/MS Method for Simultaneous Quantitation of Norgestrel and Norgestimate in Human Plasma; Shuyu Hou ; Sheth Raj ; Hongkun Liang ; Yuan-Shek Chen ; Hsu Ben ; QPS, LLC, Newark, DE WP 78 Rapid Analysis of Ceftriaxone in Human Intestinal Chyme, Human Plasma, and Dog Plasma by HPLC/MS/ MS; Todd Lusk ; John F Kokai-Kun ; Michael Schlosser ; Stacey Zeman ; Sara Brady ; Daniel Mulvana 4 ; Thad Yousey 5 ; Q² Solutions Bioanalytical and ADME Labs, Ithaca, NY; Synthetic Biologics, Inc., Rockville, MD; MSR Pharma Services, Inc., Lincolnshire, IL; 4 Q² Lab Solutions Bioanalytical and ADME Labs, Ithaca, NY; 5 Quintiles, Ithaca, NY 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 6

162 GENERAL THURSDAY INFORMATION POSTERS Set up all Thursday posters...7:0 8:00 am Odd-numbered posters present...0:0 am :00 pm Even-numbered posters present...:00 :0 pm Remove all Thursday posters...:0 :00 pm Ambient Ionization: Fundamentals and Instrumentation (Dart/Plasma, Laser, SAWN) Biomarkers: Discovery (Part ) Biomarkers: Quantitative Analysis (Small Molecules & Metabolites) Drug Metabolism: Quantitative Analysis Food Safety: Other Contaminants (Part ) GCMS: Instrumentation and Applications (Applications) H/D Exchange: Protein Structure/Function (Part ) Imaging MS: Method Development (MALDI) Imaging MS: Small Molecules Informatics: General, SRM, and DIA Informatics: Protein ID and Quantification Instrumentation: New Developments in Ionization and Sampling (Ionization) Ionization Mechanisms LC-MS: Sample Preparation (Part ) Lipids: Quantitative Analysis MALDI: Sample Preparation Metabolomics: Identification of Unknown Metabolites Metabolomics: Quantitative Analysis Natural and Nanomaterials Peptides: Fragmentation Mechanisms Peptides: Quantitative Analysis Peptides: Sequence Analysis Peptidomics Protein Therapeutics: Structural Characterization Proteins: Conformation Analysis and Structural Biology Proteins: PTMs (Part ) Proteomics: New Approaches (Other) Proteomics: Quantitative (Pre-MS and Platforms/Informatics/ MultiOmics/Dynamics) Proteomics: Tissue Small Molecules: Quantitative Analysis (Part ) Systems Biology (Protein Modifications and Cells) Toxicology Ambient Ionization: Fundamentals and Instrumentation (Dart/Plasma, Laser, SAWN) ThP 00 Dopant-Assisted Direct Analysis in Real Time (DART) Ionization with Argon Gas; Robert B. Cody ; A. John Dane ; JEOL USA Inc., Peabody, MA ThP 00 Method Development of High Throughput Lipid Analysis in Foods by Direct Analysis in Real Time Mass Spectrometer (DART-MS); Jun Watanabe ; Sakakura Motoshi ; Shiota Teruhisa ; Shimadzu Corporation, Kyoto; AMR Inc., Tokyo, Japan ThP 00 Acoustically Levitated Drops: A Containerless Microreactor Coupled with Ambient Ionization Mass Spectrometry; Elizabeth A Crawford ; Cemal Esen ; Dietrich A Volmer ; Saarland University, Saarbrücken, Germany; Ruhr-University Bochum, Bochum, Germany ThP 004 Application of Direct Analysis in Real Time-Mass Spectrometry to the Study of Oxidation of Skin Oil Components with Indoor Ozone; Shouming Zhou ; Matthew Forbes ; Jonathan P D Abbatt ; University of Toronto, Toronto ON, Canada; Department of Chemistry, University of Toronto, Toronto, ON ThP 005 Development of a Flavor Release Analysis Method on Volatile Compounds of Citrus Fruits by DART MS; Sagawa Takehiko ; Matsumoto Keiko ; Watanabe Jun ; Takei Chikako ; Sakakura Motoshi 4 ; Shiota Teruhisa 4 ; Matsufuji Hiroshi 5 ; S & B Foods Inc., Tokyo, Japan; Shimadzu Corporation, Kyoto, Japan; Bio Chromato, Inc. Fujisawa, Japan; 4 AMR Inc., Tokyo, Japan; 5 Nihon University, Fujisawa, Japan ThP 006 Direct Quantification Technique for Natural Moisturizing Factor (NMF) in Stratum Corneum by Direct Analysis in Real Time Mass Spectrometry (DART-MS); Katsuyuki Maeno ; Yasuo Shida ; Haruo Shimada ; Shiseido Global Innovation Center, Yokohama, Japan; University of Yamanashi, Kofu, Japan ThP 007 Accurate Quantification of Urinary Creatinine by Stable Isotope Dilution and DART Coupled to Quadrupole Time-of-Flight Mass Spectrometry; Ning Zhang, ; Yuanyuan Song ; Meiling Lu ; Weibing Zhang ; Hailin Wang ; Xiaokun Duan 4 ; Charles C. Liu 4 ; Research Center for Eco-Environmental Sciences, Beijing, China; East China University of Science and Technology, Shanghai, China; Agilent Technologies (China) Limited, Beijing, China; 4 ASPEC Technologies LTD, Beijing, China ThP 008 Research of Real-Time Monitoring Method for Volatiles in Chinese Liquor (Baijiu) Tasting; Ming Liu ; Zijing Xu ; Jianghao Lu ; Yi Zhang ; Qiding Zhong ; Xiaomei Yuan ; Zhenghe Xiong ; Xiaokun Duan ; Kai Liu ; China National Research Institute of Food & Fermentation Industries, Beijing, China; Sichuan Jiannanchun Group Co. Ltd, Mianzhu, Sichuan; ASPEC Technologies LTD, Beijing, China ThP 009 Screening Analysis of Primary Aromatic Amines in Textiles using DART-MS; Yamamura Yutaro ; Maeda Kengo ; Jun Watanabe ; Sakakura Motoshi 4 ; Shiota Teruhisa 4 ; Shimadzu Corporation, Kyoto, Japan; Shimadzu Co., Kyoto, Japan; Shimadzu Corporation, Kyoto; 4 AMR Inc., Tokyo, Japan ThP 00 A Study of DART as a Technique for Ambient Surface Analysis of Polymers; Dana Reed ; Katri Huikko ; Steven Pachuta ; Ali Rafati ; M Corporation, St. Paul, MN ThP 0 On-line Coupling of Surface Plasmon Resonance to Ambient Mass Spectrometry; Huwei Liu ; Yiding Zhang ; Yu Bai ; Peking University, Beijing; Peking University, Beijing, China ThP 0 An Interface for Online Coupling Surface Plasmon Resonance with Mass Spectrometry using Dielectric Barrier Discharge Ionization; Yiding Zhang ; Yu Bai ; Huwei Liu ; Peking University, Beijing, China ThP 0 Determination of Peroxide Explosives and Related Compounds by Dielectric Barrier Discharge Ionization- Mass Spectrometry (DBDI-MS); Sebastian Hagenhoff ; Heiko Hayen ; University of Muenster, Muenster, Deutschland ThP 04 Surface Erosion and Analysis of Polymer Sample via Micro Dielectric Barrier Plasma Jet Mass Spectrometry; Songyue Shi ; Xiaoxia Gong ; Xinyue Liang ; Gerardo Gamez ; Texas Tech University, Lubbock, TX ThP 05 Low Temperature Plasma Desoption/Ionization Mass Spectrometry for Quantitative Analysis of Exhaled Breath Collected on Filter Substrates; Xiaoxia Gong ; Songyue Shi ; Xinyue Liang ; Mohammad Choudhury ; Gerardo Gamez ; Texas Tech University, Lubbock, TX ThP 06 Effects of Molecular Gas Addition on a Helium Flowing Atmospheric Pressure Afterglow (FAPA) Ambient Desorption/Ionization (ADI) Source; Sunil Badal ; Jacob T. Shelley ; Department of Chemistry and Biochemistry, Kent State University, Kent, OH ThP 07 Reactive Ambient Mass Spectrometry with Flowing Atmospheric Pressure Afterglow; Gerardo Gamez ; Xiaoxia Gong ; Xinyue Liang ; Songyue Shi ; Mohammad Choudhury ; Texas Tech University, Lubbock, TX ThP 08 A Microwave Plasma for Simultaneous Molecular and Atomic Ambient Ionization of Solids; Kenyon Evans- PAGE 6 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

163 THURSDAY POSTERS Nguyen ; Jon Gerling ; Ashley Windom ; University of Tampa, Tampa, FL; Gerling Applied Engineering, modesto, CA - California; The University of Tampa, Tampa, FL ThP 09 Automatic Analyte Ion Recognition and Background Removal for Ambient Mass Spectrometry Data Based on Cross Correlation; Yi You ; Sunil P. Badal ; Jacob T. Shelley ; Department of Chemistry and Biochemistry, Kent State University, Kent, OH ThP 00 Characterization of Chemical Noise in AP MALDI using LTQ and Orbitrap Mass Spectrometer; eugene Moskovets ; Vladimir M Doroshenko ; Shelley N Jackson ; Amina S Woods ; MassTech Inc, Columbia, MD; MassTech, Inc Columbia, MD; NIDA-IRP, NIH Baltimore, MD ThP 0 Magnetic-Field-Assisted Laser-Ablation Ambient Mass Spectrometry; Yao Lu ; Yun Shen Zhou ; Lei Liu ; Xi Huang ; Yongfeng Lu ; Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE ThP 0 Sensitivity Improvement of Infrared Laser Atmospheric Pressure Ionization Mass Spectrometry by Synchronizing a Q-TOF Mass Spectrometer and the Laser Pulse; Hashiya Homare ; Iguchi Yasunari ; Hazama Hisanao ; Awazu Kunio ; Osaka University, Suita; Osaka University, Suita, Japan ThP 0 Coaxial Gas Flow Enhances Sample Plume Transfer Efficiency for Remote Laser Ablation Electrospray Ionization Mass Spectrometry; Jarod Fincher ; Brent Reschke ; Nicholas Morris ; Akos Vertes ; The George Washington University, Washington, DC; Protea Biosciences, Inc. Morgantown, WV ThP 04 Using Rapid Evaporative Ionisation Mass Spectrometry (REIMS) to Identify Microorganisms at Species Level from Pure and Mixed Cultures; Simon Cameron ; Frankie Bolt ; Adam Burke ; Zsolt Bodai ; Alvaro Perdones-Montero ; Julia Balog ; Tamas Karancsi ; Daniel Simon ; Richard Schaffer ; Tony Rickards ; Kate Hardiman ; Monica Rebec ; Zoltan Takats ; Imperial College London, London, UK; Waters Research Center, Budapest, Hungary; Imperial College Healthcare NHS Trust, London, UK ThP 05 Surface Acoustic Wave Nebulization Sample Introduction for Vacuum-Assisted Plasma Ionization; Stephen Zambrzycki ; Matthew C Bernier ; Joel Keelor ; Sung Hwan Yoon ; David R Goodlett ; Facundo M Fernandez ; Georgia Institute of Technology, Atlanta, Georgia; Georgia Institute of Technology, Atlanta, GA; University of Maryland School of Pharmacy, Baltimore, MD ThP 06 Surface Acoustic Wave Nebulization Mass Spectrometry: A Tool for Rapid Analysis of Food Products; Gloria S Yen ; Thomas Schneider ; Benjamin L Oyler ; Sung Hwan Yoon ; Tao Liang ; David P A Kilgour ; Erik Nilsson ; David R Goodlett, ; Deurion LLC, Seattle, WA; University of Maryland, School of Pharmacy, Baltimore, MD; Nottingham Trent University, School of Science & Technology, Nottingham, UK ThP 07 Performance Characterization of Surface Acoustic Wave Nebulization for Lipid A Mass Spectrometric Analysis; Tao Liang ; Thomas Schneider ; Sung Hwan Yoon ; Benjamin L Oyler ; Andrew Dennison ; Gloria S Yen 4 ; Yue Huang 4 ; Adam A Stokes 5 ; Anthony J Walton ; Robert K Ernst 6 ; Erik Nilsson 4 ; David R Goodlett, 4 ; University of Maryland School of Pharmacy, Baltimore, MD; School of Pharmacy, University of Maryland Baltimore, MD; School of Chemistry, The University of Edinburgh, Edinburgh, UK; 4 Deurion LLC, Seattle, WA; 5 School of Engineering The University of Edinburgh, Edinburgh, UK; 6 University of Maryland Baltimore School of Dentistry, Baltimore, MD ThP 08 Surface Acoustic Wave Nebulization Mass Spectrometry on a TripleTOF Mass Spectrometer; Thomas Schneider ; Benjamin L Oyler ; Larry J Campbell ; Yves J C LeBlanc ; Tom Covey ; Gloria S Yen 4 ; Erik Nilsson 4 ; David R Goodlett ; University of Maryland School of Pharmacy, Baltimore, MD; AB SCIEX, Concord, Canada; AB SCIEX, Concord ON, Canada; 4 Deurion LLC, Seattle, WA ThP 09 Rapid Identification of Adulterated Edible Oils by DART-QTOF system; Tanxi Cai ; Xiaokun Duan ; Peng Wu ; Lili Niu ; Fuquan Yang* ; Charles C. Liu ; Institute of Biophysics, CAS, Beijing, China; ASPEC Technologies LTD, Beijing, China; Institute of Biophysics, CAS beijing, China ThP 00 Analysis of Metallocene using Atmospheric Pressure Chemical Ionization and Atmospheric Pressure Photo Ionization Coupled with Ion Mobility Mass Spectrometry; Mathilde Farenc,, ; Budagwa Assumani, ; Carlos Afonso, ; Pierre Giusti, ; TOTAL Refining and Chemicals, TRTG Gonfreville l Orcher, France; Normandie Univ, CNRS UMR 604 COBRA Mont St Aignan, France; TOTAL RC - CNRS Joint Laboratory CMC :Complex Matrices Molecular Characterization, France Biomarkers: Discovery (Part ) ThP 0 Non-Target Urinary and Serum Metabonomic Study of Radix Astragali Treated on Rheumatoid Arthritis Rats Using UPLC-Q-TOF-HDMS; Zhiqiang Liu ; Tengfei Xu ; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, CN ThP 0 Potential Diagnostic Biomarkers and Pathway Analysis of Ovarian Cancer by Lipidomics; Yangyang Zhang; Institute of Chemistry,Chinese Academy of Sciences, Beijing, China ThP 0 Death Domain Associated Protein DAXX May Regulate a Distinct Lipid Metabolism Signature in Breast Cancer; Iqbal Mahmud ; Timothy J Garrett ; Daiqing Liao ; University of Florida, Gainesville, FL ThP 04 Identification of Unusual Bile Acids as Biomarkers for Niemann-Pick C Disease Using Charge-Remote Fragmentation of N-(4-Aminomethylphenyl)Pyridinium Derivatives; Xuntian Jiang ; Laurel Mydock, ; Fong-Fu Hsu ; Douglas Covey ; David E Scherrer ; Rohini Sidhu ; Forbes D Porter ; Nicole M Yanjanin ; Dennis J Dietzen ; Jean Schaffer ; Daniel Ory ; Washington University in St. Louis, St. Louis, MO; Washington University in St. Louis, St Louis, MO; NIH/NIAID, Bethesda, MD ThP 05 Human Plasma Lipidome Variations in Active Tuberculosis; Huipeng Neo,, ; Shanshan Ji 4 ; Federico Torta 4 ; Anne K Bendt 4 ; Cynthia Chee 5 ; Yee Tang Wang 5 ; Pavanish Kumar 6 ; Bhairav Paleja 6 ; Amit Singhal 6 ; Gennaro De Libero 6 ; Markus R Wenk 4 ; NUS Singapore, Singapore, Singapore; Agilent Technologies Pte Ltd, Singapore, Singapore; Department of Biological Sciences, Singapore, Singapore; 4 National University of Singapore, Singapore, Singapore; 5 Tuberculosis Unit, Tan Tock Seng Hospital, Singapore, Singapore; 6 Singapore Immunology Network (SIgN), A*STAR, Singapore, Singapore ThP 06 Mass Spectrometry-Based Metabolomics for Biomarker Discovery after Angioplasty; Yatao Shi ; Bowen Wang ; Xudong Shi ; Lian-Wang Guo ; K. Craig Kent ; Lingjun Li ; University of Wisconsin-Madison, Madison, WI ThP 07 Lysophosphatidylinositol: A Novel Biomarker of Ischemia and a Potential Prognostic Indicator of Cardiac Arrest; Koichiro Shinozaki ; Tai Yin ; Junhwan Kim ; The Feinstein Institute for Medical Research, Manhasset, NY ThP 08 Following Biomarkers of Central Metabolism in Muscles from Diabetic Mouse Model: Metabolic Pathway Imaging; Juliette Masure ; Gregory Hamm ; Philippe Delataille ; Corinne Foucart ; David Bonnel ; 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 6

164 GENERAL THURSDAY INFORMATION POSTERS Carole Belanger ; Raphael Darteil ; Jonathan Stauber ; ImaBiotech, MS Imaging Dept. LOOS, France; Genfit, Loos, France ThP 09 Analysis of Volatile Organic Compounds in Pleural Effusions by HS-SPME-cryo-trap-GC/MS; Zhongping Huang ; Jie Zhang ; Huijun Liu ; Lili Wang ; Zhejiang University of Technology, Hangzhou, China ThP 040 Controlling the Misuse of Anabolic Steroids by Steroidal Biomarkers Profiling; Kin-Sing Wong ; George H.M. Chan ; Emmie N.M. Ho ; Terence S.M. Wan ; Racing Laboratory, The Hong Kong Jockey Club, Hong Kong, China ThP 04 Serum Total Fatty Acids as Potential Biomarkers for Differentiate Benign Lung Diseases from Lung Cancer; Junling Ren ; Zhili Li ; Institute of Basic Medical Sciences, CAMS & PUMC, Bejing, CN; IBMS, CAMS&PUMC, Beijing ThP 04 Modeling the Exposome Paradigm: Exposure Analysis of the Western Honey Bee; Chloe Wang ; Malia Wenny ; Robert L Broadrup ; Christopher Mayack ; Anthony Macherone, 4 ; Haverford College, Haverford, PA; Swarthmore College, Swarthmore, PA; Agilent Technologies, Wilmington, DE; 4 Johns Hopkins University School of Medicine, Baltimore, MD ThP 04 Proteomics of Human Plasma in Heart Failure with Preserved Ejection Fraction (HFpEF) using Novel Chemical Affinity, Mixed Mode Matrix (M); Richard Mbasu ; Donald DL Jones ; Liam M Heaney ; Leong L Ng ; Sandhu K Jatinderpal ; Paulene Quinn ; Daniel C Chan ; University of Leicester, Leicester, Leicestershire; University of Leicester, Leicester, UK ThP 044 Mass Spectrometry Based Proteomics to Investigate and Characterize the Jumping Translocation Breakpoint (JTB) Protein using Cancer Cell Lines; Devika Channaveerappa ; Kangning Li ; Costel C. Darie ; Clarkson University, Potsdam, NY ThP 045 Label-free Shotgun Proteomics Identifies Markers of Inflammation from Fetal Fibroblasts; Owen E Branson ; Brian C Wulff ; Miranda L Gardner ; Traci A Wilgus ; Michael A. Freitas ; Ohio State University, Columbus, OH ThP 046 Mass Spectrometry Based Proteomic Investigation of Plasma Samples from Children with Autism Spectrum Disorder (ASD) and Matched Controls; Kelly Wormwood ; Megan M Borland ; Emmalyn J Dupree ; Alisa G Woods ; Blythe Corbett ; Costel C Darie ; Clarkson University, Potsdam, NY; Vanderbilt University, Nashville, TN ThP 047 Using LC-MS/MS and Stable Isotope Tracers to Explore Circulating Biomarkers for the Kinetics of Liver Fibrosis ; Haihong Zhou ; Yangqing Kan ; Ying Chen ; Ye Tian ; Yongcheng Huang ; Yonghua Zhu ; Taro Akiyama ; David Kelley ; Stephen Previs ; Shirly Pinto ; Merck & Co., Inc., Kenilworth, NJ; Merck & Co, Kenilworth, NJ ThP 048 Quantitative Proteomic Analysis of Serum Exosomes from Patients with Pancreatic Cancer Reveals the Differentially Expressed Proteins after Chemo-/Radio- Treatment; Mingrui An ; Zhijing Tan ; Jianhui Zhu ; Jing Wu ; Jun Cao ; Rui Yang ; Xiucong Pei ; David M. Lubman ; University of Michigan, Ann Arbor, MI; University of Michigan Medical Center, Ann Arbor, MI ThP 049 Development of an Integrated and Effective Pipeline for Profiling Microbial Proteins from Mouse Fecal Samples by LC-MS/MS; Jing Wu ; Jianhui Zhu ; Haidi Yin ; Mingrui An ; Nicholas Pudlo ; Eric Martens ; Grace Chen ; David M Lubman ; University of Michigan Medical Center, Ann Arbor, MI ThP 050 CD90 Expression is Associated with Pancreatic Intraepithelial Neoplasias; Xiucong Pei ; Jianhui Zhu ; Rui Yang ; Jiaqi Shi ; Zhijing Tan ; Mingrui An ; David M Lubman ; University of Michigan Medical Center, Ann Arbor, MI; University of Michigan Medical School, Ann Arbor, MI ThP 05 Facilitate Biomarker Discovery using Integrated Omics Differential Analysis with High Resolution Accurate LC/MS Approach; Reiko Kiyonami ; Julian A Saba ; Sergei I Snovida ; David Peake ; Devin Drew ; Andreas Huhmer ; Ken Miller ; ThermoFisher Scientific, San Jose, CA; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Rockford, IL ThP 05 Proteomic Analysis of Minute Amount of Colonic Biopsy Samples from Patients by Enteroscopy for Biomarker Discovery; Xing Liu ; Zhou Hu ; Xu Yanli ; Chinese Academy of Sciences, Shanghai, China; Fuyang People s Hospital, Fuyang, China ThP 05 Early Diagnostic Biomarkers for Acute Liver Transplantation Rejection; Su Jung Kim ; Ji Hyun Kim ; Na Young Kim ; Shin Hwang ; Hyun Ju Yoo ; Asan Institute for Life Sci, Asan Medical Center Seoul, South Korea; Dep. Liver Transplantation and Heptobiliary Surgery, Asan Medical Center, Seoul, Republic of Korea; Biomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Seoul ThP 054 The Identification of Biomarkers of Normobaric Hypoxia and Recovery via Exhaled Breath; Sean Harshman ; Brian Geier ; Leslie Drummond ; Laura Flory ; Maomian Fan 4 ; Jeffrey Phillips ; Darrin Ott 5 ; Claude Grigsby 4 ; UES Inc, Air Force Research Laboratory, WPAFB, OH; UES, WPAFB, OH; Naval Medical Research Unit-Dayton, WPAFB, OH; 4 Air Force Research Laboratory, WPAFB, OH; 5 US AF School of Aerospace Medicine, WPAFB, OH ThP 055 Integration of Tissue and Urine Proteomes for Biomarker Discovery and Verification of Renal Cell Carcinoma; Yi-Ting Chen,, ; Chien-Lun Chen 4, 5 ; Jau- Song Yu, ; Pei-Chia Wang ; Hsiao-Wei Chen ; Ying-Hsu Chang 6, 7 ; Yu-Sun Chang, ; Ting Chung ; Tsung-Shih Lin ; Department of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 4 Department of Urology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5 School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 6 Division of Urology, Department of Surgery; LinKou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 7 Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan ThP 056 N-terminal Endogeneous Fragments of Tau in Human Cerebrospinal Fluid; Gunnar Brinkmalm ; Claudia Cicognola ; Erik Portelius ; Henrik Zetterberg, ; Kaj Blennow ; Kina Höglund, ; University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology, London, UK; Karolinska Institutet, Huddinge, Sweden ThP 057 Developing a Lysosomal Panel for Biomarker Discovery in Neurodegenerative Diseases using PRM; Simon Sjödin ; Gunnar Brinkmalm ; Annika Öhrfelt ; Henrik Zetterberg, ; Kaj Blennow ; Ann Brinkmalm ; University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology, London, UK ThP 058 Longitudinal Profiling of Type Diabetes Human Plasma Using TMT0-based Quantitative Proteomics Approach; Chih-Wei Liu ; Lisa Bramer ; Bobbie-Jo Webb- Robertson ; Kathleen Waugh ; Marian J Rewers ; Qibin Zhang ; University of North Carolina at Greensboro, Greensboro, NC; Pacific Northwest National Laboratory, Richland, WA; University of Colorado School of Medicine, Aurora, CO PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

165 THURSDAY POSTERS Biomarkers: Quantitative Analysis (Small Molecules & Metabolites) ThP 059 Profiling of Medium-to-Long Chain acyl-coas Converted from Metabolism of Exogenous Fatty Acids in Mammalian Cells using LC-MS/MS; Xiangkun Yang; University of Georgia, Athens, GA ThP 060 A Validated Multiplex Assay for the Quantification of Tryptophan and Four of Its Catabolites in Human Plasma and Cerebrospinal Fluid; Joachim Hoke ; Andre Liesener ; Stefan Blech ; Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany ThP 06 In vivo Metabolic Profiling of the TCA Cycle; Stephanie Dale ; Sheerin Shahidi-Latham ; E. Ellen Jones ; Cristine Quiason ; Genentech Inc, South San Francisco, CA ThP 06 Comprehensive Profiling of Neurotransmitters in Cerebrospinal Fluid by LC-MS/MS; Kanta Horie ; Yoshiaki Sato ; Takashi Kosasa ; Takeyasu Tomioka ; Motohiro Shiotani ; Makoto Ogo ; Yoshiya Oda ; Eisai Co. Ltd., Tsukuba, Japan; Eisai Inc, Woodcliff Lake, NJ ThP 06 Development of a Quantitative LC-MS Assay to Evaluate Depletion of Wall Teichoic Acid in Staphylococcus Aureus.; Olga Berejnaia; Merck & Co., Inc., Rahway, NJ ThP 064 Validation of a High-Throughput Assay for the Quantification of Unbound and Total Desmosine and Isodesmosine in Human Plasma; Andre Liesener ; Joachim Hoke ; Stefan Blech ; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany; Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany ThP 065 Rapid Quantitative Analysis of 5 Major Bile Acids in Human Serum by UPLC-Tandem Mass Spectrometry; Tian-Sheng Lu ; Aiping Zhu ; Wanqing Lu ; Emily Epure ; Yong-Xi Li ; Medpace Bioanalytical Laboratories, Cincinnati, OH ThP 066 A Simultaneous Quantification Method Oftricarboxylic Acid Cycleprecursors and Intermediates; Paul Rainville ; Robert Plumb ; Jose Castro-Perez ; James Langridge ; Waters, Milford, MA ThP 067 Challenges in Development of LC-MS Methods for Highly Polar, Low Molecular Weight Compounds: A Quantitative Assay for Quinolinic Acid; Regina Oliveira ; Asoka Ranasinghe ; Joelle M Onorato ; Celia D Arienzo ; Petia A Shipkova ; Bristol-Myers Squibb, Princeton, NJ ThP 068 Development and Validation of a Method for the Determination of Total Plasma Cholesterol Levels to Support 4β-Hydroxycholesterol Biomarker Studies; Mark Leahy ; Matt Byers ; Victoria Jennings ; Joanne Hanson ; Covance, Madison, WI; Covance, Harrogate, UK ThP 069 Chiral Chromatography-Stable Isotope Dilution- Multiple Reaction Monitoring Mass Spectrometry for Characterization and Quantification of Complex Lipids in Human Biological Matrices; Reza Nemati Josheghani ; Christopher Dietz ; Emily Anstadt ; Robert Clark ; Michael Michael Smith ; Frank Nichols ; Xudong Yao ; University of Connecticut, Storrs, CT; University of Connecticut, Farmington, CT ThP 070 Simultaneous Determination of Dehydroepiandrosterone (DHEA) and 7 Hydroxyprogesterone (7-OHP) in Human Plasma using LC-MS/MS; Guangnong Zhang ; Gaungchun Zhou ; Feng Yin ; Morgan Byrd ; Tian-Sheng Lu ; Yong-Xi Li ; Medpace Bioanalytical Laboratories, Cincinnati, OH ThP 07 Quantitative Analysis of Serum -Hydroxyglutarate using Gas Chromatography-Mass Spectrometry; Salil Kumar Bhowmik, ; Nagireddy Putluri, ; Arun Sreekumar,,4 ; Dept. of Molecular and Cell Biology, Baylor College of Medicine, Houston, TX; Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX; Advanced Technology Core, Baylor College of Medicine, Houston, TX; 4 Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX ThP 07 Scaling Up: Improving Automated, High Throughput Measurement of Tobacco-Specific Nitrosamines in Urine by Liquid Chromatography-Atmospheric Pressure Ionization Tandem Mass Spectrometry; Baoyun Xia ; Christina R Brosius ; Yang Xia ; Tonya Guillot ; John Lee ; Keegan J Nicodemus ; Dana Freeman ; Justin Lamar Brown ; Li Zhang ; Lanqing Wang ; Centers for Disease Control and Prevention, Atlanta, GA; ORISE Centers for Disease Control and Prevention, Atlanta, GA; Battelle Memorial Institute, Atlanta, GA ThP 07 A Simple, Robust Method for Quantitative Analysis of Bile Acid Biomarkers in Human, Monkey, Dog, Mouse, and Rat Plasma Samples; Angela Qi Shen ; Alyssa Kabat ; Wenlin Yuan ; Ritika Kurian ; Brittany Perley ; Steven Wiltshire ; Agilux Laboratories, Worcester, MA ThP 074 Quantitation of -Hydroxyglutarate and α-ketoglutarate: Impact of Matrix Selection; Vikki M Tsefrikas ; Kyle S. Goodsell ; Dylan S. Bennett ; David Brigham ; Allysen Meymaris ; Agilux Laboratories, Worcester, MA ThP 075 Identification of Plasma Phospholipids that Distinguish Normal Subjects from Asthma Patients and Separating Patients of Lower Airway Diseases; Hay-Yan J. Wang ; Zhi-Fu Zheng ; Kuan-Lun Su ; Chau-Chyun Sheu ; Shau- Ku Huang 4 ; National Sun Yat-Sen University, Kaohsiung, Taiwan; National Sun Yat-Sen University, Kaohsiung, Taiwan; Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 4 National Health Research Institutes, Miaoli, Taiwan ThP 076 Quantitation of the Organic Acid Biomarkers Pyruvate and Lactate in Biological Matrices; Dylan Bennett ; Allysen Meymaris ; Vikki Tsefrikas ; Agilux Laboratories, Worcester, MA ThP 077 Quantitative Analysis of Short Chain Fatty Acids and Ketone Bodies in Plasma and Tissues as Oximes Derivatives by LC-MS/MS ; Huachuan Marc Cao ; Mingfei Zeng ; Eli Lilly and Company, Shanghai, China ThP 078 Quantitation of (C:6)-bis(monoacylglycerol) phosphate and Profiling of Additional BMPs in Rat Urine as Markers of Phospholipidosis; Joelle Onorato ; Petia Shipkova ; Mike Reily ; Yan He ; David Nelson ; Lois Lehman-McKeeman ; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb Co., Princeton, NJ; Bristol Myers Squibb, Princeton, NJ ThP 079 Identification and Quantification Method for AG, AG and Arachidonic Acid in Plasma, CSF and Brain by LC- MS/MS: ; Shakey Quazi; Pfizer, Andover, MA ThP 080 Quantitative Analysis of D-Alanine in Cerebral Spinal Fluid Using a Chiral HPLC Coupled with High Resolution Mass Spectrometry; Brendan Tierney ; Christopher Holliman ; Hongying Gao ; Pfizer, Inc., Groton, CT ThP 08 High Throughput UPLC-MS/MS Method for the Profiling of Hydrosoluble Vitamins in Human Plasma; Oksana Lavrynenko ; Serge Rezzi ; NIHS, Molecular Nutrition Group, Lausanne, CH ThP 08 Detection of Aromatic Amines in Human Urine at ppt Level: a Semi-Automated Hamilton STAR/GC/MS/MS Method; Tiffany Seyler ; Elizabeth Cowan ; Susan Pyatt ; Aaron Danberry ; Kyle Emer ; CDC, Atlanta, GA; Former Associate Fellow, Atlanta, GA; Former ORISE Fellow, Atlanta, GA ThP 08 LC-MS/MS Quantitative Analysis of the Biomarkers Tryptophan, Kynurenine, and Kynurenic Acid in Mouse and Rat Plasma and Brain; Alyssa Kabat ; Brittany Perley ; Steven Wiltshire ; Agilux Laboratories, Worcester, MA 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 65

166 GENERAL THURSDAY INFORMATION POSTERS ThP 084 Bioactivation of Heterocyclic Aromatic Amines by UDP Glucuronosyltransferases; Tingting Cai ; Lihua Yao ; Robert Turesky ; University of Minnesota at Twin Cities, Minneapolis, MN ThP 085 Urine Steroid Metabolite Profiling Using LC-HRAMS for Diagnosing Adrenal Cortical Carcinoma; Jolaine Hines ; Irina Banocs ; Robert L Taylor ; Raman Deep Singh ; Aditya V Avula ; Stefan K Grebe ; Ravinder J Singh ; Mayo Clinic, Rochester, MN ThP 086 Quantification of Lathosterol in Human Plasma Using UPLC-MS/MS System; Guangchun Zhou ; Tian-Sheng Lu ; Nicole Greer ; Yong-Xi Li ; Medpace Bioanalytical Laboratories, Cincinnati, OH ThP 087 Determination of Amino Acids and Biogenic Amines in Plasma and Urine in Cri Du Chat Disease by Mass Spectrometry; Danielle Zildeana Furtado ; Leticia Dias Lima Jedlicka ; Heron Domingues Silva ; Nilson Antonio Assunção, ; UNIFESP, São Paulo, Brasil; The Scripps Research Institute, La Jolla, CA ThP 088 Multiplex Quantitative Localized Analysis of Metal- Tagged Antibodies using Event-By-Event Cluster Secondary Ion Mass Spectrometry; Dmitriy Verkhoturov ; Kyungjin Son ; Stanislav V Verkhoturov ; Michael J Eller ; Alexander Revzin ; Emile A Schweikert ; Texas A&M University, College Station, TX; University of California- Davis, Davis, CA ThP 089 Improvements in LFQ for Reproducible Quantification of Proteomic Experiments: How DDA Outperforms DIA; Ignacio Ortea ; Michael Blank ; Romain Huguet ; David M Horn ; Daniel Lopez Ferrer ; Andreas Huhmer ; IMIBIC, Cordoba, Spain; Thermo Fisher Scientific, San Jose, CA; ThermoFisher, Palo Alto, CA Drug Metabolism: Quantitative Analysis ThP 090 Anti-Cancer Drug Detection at the Single Cell Level; Shawna Standke ; Ning Pan ; Naga Rama Kothapalli ; Zhibo Yang ; Anthony W. Burgett ; University of Oklahoma, Dept. of Chem & Biochem Norman, OK ThP 09 Comparative Studies on Intrinsic Clearance Predication of Low Turnover Compounds Using the Regular and Relay Cryopreserved Hepatocyte Methods; Min Jiang ; Zhican Wang ; Dan Rock ; Amgen, South San Francisco, CA; Amgen, Inc. South San Francisco, CA ThP 09 Evaluation of QTOF HRMS Platform for Highly Sensitive Analysis of Raltegravir in Plasma in Support of Human Microdosing; Li Sun ; Kevin Bateman ; Sukhdev Bangar ; Yun W Alelyunas ; Mark Wrona ; Sheila Breidinger ; Eric Woolf ; Merck & Co., Inc., West Point, PA; Waters Corporation, Beverly, MA; Waters, Milford, MA ThP 09 Characterization of Ketamine Metabolism in Liver S9 Fractions from Aging Sprague Dawley Rats by Liquid Chromatography Tandem Mass Spectrometry; Raphaël Santamaria ; Marie-Chantal Giroux ; Pascal Vachon ; Francis Beaudry ; Université de Montréal, St-Hyacinthe, QC ThP 094 Methods for Analysis of Hydroxywarfarin Regio- and Stereoisomers in Bioanalytical Samples; Karin Keller ; Laura Drake ; Crystal D Sergent ; Edward Wells ; Steve E Unger ; Worldwide Clinical Trials, Austin, TX ThP 095 Determination of Cariprazine and Metabolites in Human Plasma by LC-MS/MS; Jing Ke ; Guiyan Chen ; Allan Xu ; Keystone Bioanalytical Inc, North Wales, PA ThP 096 Characterization of clozapine-n-oxide using LC-MS/ MS; Jeffrey F Kuhn ; Yu-wei Chen ; Patricia Jensen ; Leesa Deterding ; NIEHS, RTP, NC ThP 097 Development and Validation of a Novel Enzyme Inhibition Assay for Determination of Statin Acid in Human Plasma using LC-MS/MS; Yanjun Hu ; Huafang Jiang ; Junxian Zhao ; Wanhui Liu ; Xinping Fang ; Xin Zhang ; Wenzhong Liang ; WuXi AppTec (Shanghai) Co. Ltd., Shanghai, China; Luye Pharma Group Co., Ltd, Yantai, China; WuXi AppTec (Shanghai) Co. Ltd., Shanghai, Shanghai ThP 098 Development and Validation of the Determination of Total CRS in Human Urine by High Performance Liquid Chromatography Tandem Mass Spectrometry; X. Steven Yan ; Marsha L. Luna ; ChenYu Chung ; Julie Showalter ; Yansheng Liu ; Matthew E Hinz ; KCAS Bioanalytical & Biomarker Services, Shawnee, KS; DynPort Vaccine Company, Frederick, MD ThP 099 LC-MS/MS Method for the Quantification of Fingolimod and Fingolimod Phosphate in Rat blood with Storage Stability; Rajesh Kumar Boggavarapu ; Nagasurya Prakash Padala ; Praveen kunduru ; Devender Reddy Ajjala ; Ramakrishna Nirogi ; Suven Life Sciences Ltd, Hyderabad, Telangana ThP 00 Testing the Ability of UBP-0 to Diffuse into Mouse Brain via LC-MS/MS (QQQ) Quantification; Sandy Stayte ; Russell Pickford ; Justin Nash; Bryce Vissel ; Garvan Institute, Sydney, Australia; University of New South Wales, Sydney, Australia ThP 0 Solving the Enigma of Nitrate Tolerance with a Stable Isotope-Assisted, Multi-Platform Work Flow; Elizabeth Axton ; Eleonso Cristobal ; Fred Stevens ; Oregon State University, Corvallis, OR ThP 0 Using Triplicate Calibration Curves and Weighted Least Squares Regression to Reduce Experimental Error; Kenneth Anderson ; Kevin P Bateman ; Merck & Co, Inc., West Point, PA; Merck & Co., Inc., West Point, PA ThP 0 Systematic Investigation of the Failure of One Analyte during Method Transfer and Cross Check of a 4-in- LC- MS/MS Method; Bian Chao ; Daniel Neddermann ; Lihua Qiao ; Yixin Yang ; Liang Wenzhong ; Xin Zhang ; WuXi AppTec (Shanghai) Co. Ltd., Shanghai, China; Novartis Pharma AG, Basel, Switzerland ThP 04 Ionization Efficiency of Oligopeptides and Small Hydrophilic Molecules in ESI/MS; Piia Liigand ; Karl Kaupmees ; Anneli Kruve ; University of Tartu, Institute of Chemistry, Tartu, Estonia ThP 05 In-vitro Metabolic Stability and Profiling of Ponatinib, Vandetanib and Masitinib using Liquid Chromatography Tandem Mass Spectrometry; Sawsan M Amer ; Adnan A. Kadi ; Hany W Darwish, ; Mohamed W. Attwa, ; College of Pharmacy, Cairo University Cairo, Egypt; College of Pharmacy, King Saud University Riyadh, Saudi Arabia ThP 06 Unusual Matrix Effects Observed during Quantitative LC-MS/MS Methods Development; Yuyong ke ; Nicki Hughes, ; Fernand Labrie ; Bioanalytical Laboratory Services, a Division of LifeLabs LP, Toronto, Ontario; EndoCeutics, Quebec City, QC ThP 07 Evolution, Development, and Application of a Dynamic, High-Throughput, Enterprise-Level Autosampler for High-Performance LC/MS/MS Bioanalysis; Brendon Kapinos ; John S Janiszewski ; Hui Zhang ; Mary Piotrowski ; Jianhua Liu ; Wayne Lootsma ; Steven Ainley ; Pfizer, Groton, CT; Sound Analytics, Niantic, CT Food Safety: Other Contaminants (Part ) 08-4 ThP 08 Food Safety Detection of Targeted and Unknown Compounds Using OrbitrapTMLC-MS/MS System; Charles T. Yang ; Dipankar Ghosh ; Jamie Humphries ; Nick Duczak ; Caroline Ding ; Thermo Fisher Scientific, San Jose, CA; Thermo Fisher Scientific, Austin, TX ThP 09 A Multi-Residue Liquid Chromatography\Tandem Mass Spectrometry Method for the Analysis of Macrolides in Food Matrices; Pavel Metalnikov ; Ilia Batov ; Renat PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

167 THURSDAY POSTERS Selimov ; Ksenia Batova ; Alexander Komarov ; VGNKI, Moscow, Moscow; VGNKI, Moscow, Moscow ThP 0 Determination of Wilfordine and Wilforine in Honey using Liquid Chromatography with Tandem Mass Spectrometry ; Chen Jianli; Shimadzu, Wuhan, China ThP Determination and Quantification of Perchlorate in a Fruit Matrix Using Accelerated Solvent Extraction and IC-MS; Kyle Renfrew; Amanda Hartman ; Nicholas Santiago; Thermo Fisher Scientific, Austin, TX ThP Determination of Papaverine and Other Alkaloids in Hot Pot Condiment by Direct Analysis in Real Time Mass Spectrometry; Yi Li ; Weixia Wang ; Xiaohui Xiong ; Jiehui Hu ; Charles C. Liu ; Nanjing Tech University, Nanjing, Jiangsu; ASPEC Technologies Limited, Beijing, BeiJing ThP Use of Ambient Ionization Mass Spectrometry for the Rapid Authentication of Food and Dietary Supplements; Kari Organtini ; Gareth Cleland ; Beth Loecken ; Adam Ladak ; Waters, Milford, MA ThP 4 Accessible and Efficient Screening of Multiclass Contaminants in Food; Eimear McCall ; Ramesh Rao ; Adam Ladak ; Jennifer Burgess ; Waters, Wilmslow, UK; Waters, Milford, MA ThP 5 Authentication and Chemical Standardization of Licorice Dietary Supplements Using UHPLC-MS/MS; Guannan Li, ; Charlotte Simmler, ; Dejan Nikolic, ; Shao- Nong Chen, ; Guido F. Pauli, ; Richard B. van Breemen, ; UIC/NIH Center for Botanical Dietary Supplements Research, Chicago, IL; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL ThP 6 Analysis of Phosphodiesterase Type 5 Inhibitors Extracted from Herbal Preparations by DSA-TOF MS; Robert J. Seward ; Jason Weisenseel ; Craig Young ; Wilhad M. Reuter ; PerkinElmer, Waltham, MA ThP 7 Simultaneous Determination of Multiple Plant Growth Regulators in Bean Sprouts using Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry; Cheng Zheng ; Qiaoyuan Cheng ; Weifang Ni ; Chengyuan Cai ; Jingchao Lin ; Yongming Xie ; Zhejiang Institute of Food and Drug Control, Hangzhou, China; PerkinElmer Management (Shanghai) Co., Ltd, Shanghai, China ThP 8 High Sensitive Analysis of Peanut Allergen in Cumin and Spice Mix; Clifford Robert ; Tairo Ogura ; Shimadzu Scientific Instruments, Columbia, MD ThP 9 Simultaneous Determination of Hormones in Edible Bird s Nest using Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry; Dunming Xu ; Liping Zhong ; Sanmei Zeng ; Lizhong Yang ; Chengyuan Cai ; Jingchao Lin ; Yongming Xie ; Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen, China; PerkinElmer Management(Shanghai)Co., Ltd, Shanghai, China ThP 0 Mass Spectrometry Based Methods to Detect the BoNTE in Catfish Specimen; Tibor Pechan ; Olga Pechanova ; Jennifer Arnold ; Mississippi State University, Mississippi State, MS; Mississippi State University, Starkville, MS; Edward Via College of Osteopathic Medicine - Carolinas Department of Biomedical Science, Spartanburg, SC ThP Rapid Screening and Quantitation of Domoic Acid in Shellfish Homogenates using Laser Ablation Electrospray Ionization Mass Spectrometry (LAESI- MS); Pamela S. Cantrell ; Callee M. Walsh ; Haddon E. Goodman ; Pearse McCarron ; Kelley Reeves ; Wade A. Rourke 4 ; Sinead O Brien 5 ; Daniel G. Beach ; Protea Biosciences, Morgantown, WV; Protea Biosciences, Inc. Morgantown, WV; National Research Council Canada, Halifax, Nova Scotia, Canada; 4 Canadian Food Inspection Agency, Dartmouth, Nova Scotia, Canada; 5 Marine Institute, Galway, Ireland ThP Analysis of Diarrhetic Shellfish Poisoning and Azaspiracid Shellfish Poisioning Toxins by Liquid Chromatography-Tandem Mass Spectrometry; Li Yang ; Randy Self ; James Stuart ; Theodore Lapainis ; Daniel Rice ; Wen-Hsin Wu ; James Hungerford ; Food and Drug Administration, Bothell, WA ThP Multi-analyte Investigation in Relation to the Illicit Treatment of Fish Food with Hydrogen Peroxide; Claudio Medana ; Riccardo Aigotti ; Federica Dal Bello ; Valentina Santoro ; Claudio Baiocchi ; University of Turin, Torino, Italy ThP 4 Origin Determination of Eastern Oyster (Crassostrea virginica) by Combination of Heavy Metal Concentrations, Whole-Body Bulk and Compound Specific Isotope Analyses; Mayara P. V. Matos ; Marc E Engel ; Glen P Jackson, 4 ; Department of Biology, West Virginia University, Morgantown, WV; Florida Department of Agriculture and Consumer Service, Tallahassee, FL; Department of Forensic and Investigative Science, West Virginia University, Morgantown, WV; 4 C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV ThP 5 Quantitative Determination of Veterinary Drug Residues in Eggs by UPLC-MS/MS Using a Simple, Rapid and Effective Cleanup Approach; Sujie XIa ; Dimple Shah ; Jeremy C Shia ; Michael S Young ; Adam Ladak ; Laura Suhadolnik ; Shanghai Institute for Food and Drug Control, Shanghai, China; Waters, Milford, MA ThP 6 Targeted Veterinary Drugs Screening in Food Matrix using EMR QuEChERS and Newly Developed Triple Quadrupole Mass Spectrometer; Yanan Yang ; Dan-Hui Yang ; Agilent Technologies, Inc, Santa Clara, CA; Agilent Technologies, Santa Clara, CA ThP 7 Development of Multi-Class, Multi-Residue UHPLC MS/ MS Method for Screening/Quantification of Veterinary Drugs in Complex Food Metrices and Related Products; Azeem Hasan ; Hui Zhao ; John Zulkoski ; Barb Mitchell ; Thomas Vennard ; Katerina Mastovska ; Covance, Madison, WI ThP 8 Extending the Linear Dynamic Range for Measurements Targeting Veterinary Drug Residues in Animal Feed by UPLC-laminar Flow HSID-MS/MS; Jason Kong ; Frank Kero ; Joshua Ye ; Lisa Cousins ; Craig Young ; Sharanya Reddy ; Ohio Department of Agriculture, Reynoldsburg, OH; PerkinElmer, Shelton, CT; Ionics Mass Spectrometry Group, Bolton, Canada ThP 9 Mass Spectrometry Reveals Distinct Extracellular Proteins of Food-Borne Escherichia coli O57:H7 and O04:H4; Nazrul Islam ; Attila Nagy ; Garrett M. Wesley ; Xiangwu Nou ; Bret Cooper 4 ; Dan Shelton ; University of Maryland, Colleg, College Park, MD; Environmental Microbial and Food Safety Laboratory, USDA-ARS, Beltsville, MD; Animal Biosciences and Biotechnology Laboratory, USDA-ARS, Beltsville, MD; 4 Soybean Genomics and Improvement Laboratory, USDA-ARS, Beltsville, MD ThP 0 Meat Species Identification by Protein Profiling and Spectral Fingerprinting using MALDI-TOF-MS; Man On So; The Hong Kong University of Science and Technology, Hong Kong SAR, HK ThP Dispersive Liquid Liquid Microextraction of Betaagonist Residues from Bovine Muscle and Their Determination using ESI-LC-MS/MS; Phomolo Kgothi ; Simiso Dube ; Mathew Muzi Nindi ; Botswana National Veterinary Laboratory, Gaborone, Botswana, Gaborone, Botswana; University of South Africa,, Florida Park, Roodepoort, Gauteng; University of South Africa, Department of Chemistry, College of Science Engineering and Technology, Unisa Science Campus, Florida Park, Roodepoort, South Africa 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 67

168 GENERAL THURSDAY INFORMATION POSTERS ThP Quantification of Brominated Fatty Acids in Rat Tissues and Serum using Isotope Dilution UPLC/ESI/MS/MS; Kellie Woodling ; Priyanka Chitranshi ; Goncalo Gamboa da Costa ; FDA/NCTR, Jefferson, AR ThP Matrix-Standardization and Post-Extraction Addition of Internal Standard to Overcome Challenges during LC/ MS/MS Quantification of Neomycin and Oxytetracycline in Rabbit Tissues; Aimin Tan ; Xuan Susan Gui ; Molly Wong ; Gordon Bolger ; Albert Licollari ; John C Fanaras ; Nucro-Technics, Scarborough, ON; Nucro-Technics, Scarborough ON, Canada ThP 4 Determination of Meat Authenticity using a Comprehensive Proteomic Strategy, Data-Independent Acquisition and High-Resolution Mass Spectrometry; Alberto Ruiz Orduna ; Erik Husby ; Claudia P. Martins ; Dipankar Ghosh ; Francis Beaudry ; Université de Montréal, St-Hyacinthe, QC; Thermo Fisher Scientific, San Jose, CA ThP 5 A Green Sample Preparation Method for the Determination of Chloramphenicol and Its Metabolite Residues in Meat and Milk using ESI-LCMS/MS; Ompelege E Kemokgatla ; Simiso Dube ; Mathew Muzi Nindi ; Botswana National Veterinary Laboratory, Gaborone, Botswana, Gaborone, Botswana; University of South Africa,, Florida Park, Roodepoort, Gauteng; Department of Chemistry, College of Science Engineering and Technology, Unisa Science Campus, Florida, Rooderport, Republic of South Africa, Florida Park, Roodepoort, South Africa ThP 6 Direct Quantitative Analysis of Lean Meat Essence in Pork Tissues using Internal Extractive Electrospray Ionization Mass Spectrometry; Yipo Xiao ; Haiyan Lu ; Jianyong Zhang ; Yiping Wei ; Huanwen Chen ; East China Institute of Technology, Nanchang, China; Department of Cardiothoracic Surgery to Second Affiliated Hospital of Nanchang University, Nanchang, China; East China University of Technology, Nanchang, Mainland ThP 7 DART-HRMS and MS/MS of Spectra of Sweeteners for Screening Beverages; Luke K Ackerman ; Romina Shah ; FDA/CFSAN, College Park, MD ThP 8 Direct Determination of Four Pyrazole Fungicidesin Grape Wines by Paper Spray Mass Spectrometry; Han Chao, ; Fan Pu ; Wenpeng Zhang ; Zheng Ouyang, ; Wenzhou Entry-Exit Inspection and Quarantine Bureau, Wenzhou, China; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN; Purdue University-Department of Chemistry, West Lafayette, IN ThP 9 Assay of Resveratrol in Red Wine by Paper Spray Tandem Mass Spectrometry and Isotope Dilution; Fabio Mazzotti ; Domenico Taverna ; Leonardo Di Donna ; Lucia Bartella ; Anna Napoli ; Giovanni Sindona ; Dipartimento di Chimica e Tecnologie Chimiche Università della Calabria, Rende, Italy; Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, Rende, Italy ThP 40 Rapid Assay of Multi-Class Antimicrobials Residues in Food of Animal Origin by Paper Spray Mass Spectrometry; Yuan Su ; Zheng Ouyang ; Purdue University, West Lafayette, IN ThP 4 Weight-loss Herbal Medicine Control Quality and Authenticity by Paper Spray Ionization Mass Spectrometry; Géssica A Vasconcelos ; Verônica Carvalho ; Carla Freitas ; Igor da Silva ; Ricardo Borges ; Wanderson Romão, 4 ; Boniek Gontijo Vaz 5 ; Federal University of Goiás, Goiânia, Brazil; Brazilian Federal Police, Brasília, Brazil; Federal Institute of Espirito Santos, Vilha Velha, Brazil; 4 Federal University of Espirito Santo, Vitoria, Brazil; 5 Federal University of Goiás, Goiânia, GO GCMS: Instrumentation and Applications (Applications) 4-7 ThP 4 Determination of Pesticide Residues in Traditional Chinese Medicinal Materials Milkvetch Root; Xizhi Wang ; Shiheng Luo ; Feifei Tian ; Guixiang Yang ; Jun Fan ; Taohong Huang ; Shin-ichi Kawano ; Yuki Hashi ; Shimadzu (China) Co., Beijing, China; Shimadzu (China) Co., Shanghai, China ThP 4 Efficient Headspace Extraction of Plasticizers from Aqueous and Ethanolic Extracts; Douglas Doster; Aspen Research Corporation, New Germany, MN ThP 44 Analysis of Isomeric Metabolites by GC-EI/PI/FI-MS; Takeshi Furuhashi ; Koji Okuda ; Akihiko Kusai ; Takemichi Nakamura ; Ryukyu University, Okinawa, Japan; JEOL Ltd., Akishima, Japan; RIKEN, Wako, Japan ThP 45 Determination of Tobacco-Specific N-nitrosamines in Mainstream Cigarette Smoke using in-pipette-tip Solid- Phase Extraction; Yan-bo Luo ; Xiao-Jing Chen ; Hong-Fei Zhang ; Xing-Yi Jiang ; Xue Li ; Xiang-Yu Li ; Feng-Peng Zhu ; Yong-Qiang Pang ; Hong-Wei Hou ; China National Tobacco Quality Supervision and Test Center, Zhengzhou, China ThP 46 Substance Characterization of Polyenthylene Polyamine by EI GC/MS; O. David Sparkman ; Kirill Ttretyakov ; Patrick Batoon ; Itsuko Iwai Iwai 4 ; Terry L. Ramus 4 ; University of the Pacific, Antioch, CA; Dakota Consulting Inc., Silver Springs, MD; University of the Pacific, Stockton, CA; 4 Diablo Analytical, Antioch, CA ThP 47 Multi Pesticides Residue Analysis in Ayurvedic Cough Syrup by GCMS/MS using QuEChERS Extraction Method; Durvesh Sawant ; Ankush Bhone ; Dheeraj Handique ; Prashant Hase ; Sanket Chiplunkar ; Jitendra Kelkar ; Ajit Datar ; Pratap Rasam ; Tina Kukreja ; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, India; G.N.I.R.D., G.N. Khalsa College Mumbai, India ThP 48 Study of the Electron Ionization Fragmentation Patterns of -Alkoxycyclohexenes; Krege M Christison, ; O. David Sparkman ; Patrickhenry Batoon ; Sven Hackbush ; Andreas H Franz ; University of the Pacific, Stockton, CA; Chevron, Richmond, CA ThP 49 Identification of Leachable Impurities from Pharmaceutical Container Closure Materials using Orbitrap Based GC-MS; Dominic Roberts ; Andrew Feilden ; Richard Barlow ; Jason Cole ; Paul Silcock ; Kyle D Silva ; Alexander Semyonov 4 ; Thermo Fisher Scientific, Runcorn, UK; Smithers Rapra, Shawbury, UK; Thermo Fisher Scientific, Ausitn, TX; 4 Thermo Fisher Scientific, Austin, TX ThP 50 Determination of Ceramides using GC/Q-TOF with a Novel High Efficiency Source; Jennifer Sanderson ; Viorica Lopez-Avila ; Sofia Nieto ; Agilent Technologies, Santa Clara, CA ThP 5 Differentiation between Type of Dialkyl Phthalates Based on their EI Mass Spectra; O. David Sparkman ; Jianhua Ren Ren ; Patrickhenry Batoon ; Krege Christison ; University of the Pacific, Antioch, CA; University of the Pacific, Stockton, CA ThP 5 Quantitative Determination of Dioxins in Drinking Water by Isotope Dilution Triple Quadrupole GC-MS/MS; Jackie Jackie ; Chong Chiew Mei ; Yeong Hui Xian Crystal ; Lahey Cynthia Melanie ; Loo Lai Chin ; Shimadzu (Asia Pacific) Pte Ltd, Singapore ThP 5 GC/MS Metabolomics: Metabolic Mapping of Prostate Cancer Cell Lines; Jan Crowley, ; Kristopher Kirmess ; Jeffrey Arbeit ; Kevin Yarasheski, ; Joseph Ippolito ; Washington University, St Louis, MO; Department of Medicine, Washington University St. Louis, MO; Washington University in St. Louis, St. Louis, MO PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

169 THURSDAY POSTERS ThP 54 Characterization of Little Cigar Smoke Tar by GC-MS; Steven Reeber ; Arunava Ghosh ; Robert Tarran ; Gary L. Glish ; The University of North Carolina at Chapel Hill, Chapel Hill, NC ThP 55 Development and Validation of an Analytical Method to Quantitate Sulfolane in Rodent Plasma by GC/MS; veronica Robinson ; Teruyo Uenoyama ; Brenda Fletcher ; Stephen Cooper ; Melanie R. Rehder Silinski ; Reshan Fernando ; Suramya Waidyanatha ; NIEHS / NIH, RTP, NC; RTI International, RTI Int Research Triangle Park, NC ThP 56 Fast and Accurate Analysis of Fluorotelomer Alcohols and Acrylates using Triple Quadrupole GC-MS/MS; Cynthia Melanie Lahey ; Guo Wei Elgin Ting ; Hui Xian Crystal Yeong ; Jackie Jackie ; Chiew Mei Chong ; Lai Chin Loo ; Shimadzu (Asia Pacific) Pte Ltd, Singapore; Nanyang Technological University, Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Singapore ThP 57 Evolved Hydrogen Gas Analysis from the Industrial Materials using a Quadrupole Mass Spectrometer; Masahiro Hashimoto ; Koji Okuda ; Makoto Okano ; Tetsuo Higuchi ; Akihiko Kusai ; JEOL Ltd., Akishima, Japan ThP 58 Quantitative Determination of Aromatic Amines Formed from Azo Dyes in Textile using GCMS/MS; Ankush Bhone ; Durvesh Sawant ; Dheeraj Handique ; Prashant Hase ; Sanket Chiplunkar ; Ajit Datar ; Jitendra Kelkar ; Pratap Rasam ; Shimadzu Analytical (India) Pvt. Ltd., Mumbai, INDIA ThP 59 Chemical Profiling of Whiskies using Orbitrap GC-MS; Roberts Dominic ; Jana Hajslova ; Michal Stupák ; Jana Pulkrabova ; Jason Cole ; Paul Silcock ; Thermo Fisher Scientific, Runcorn, UK; Institute of Chemical Technology, Prague, Czech Republic; Thermo Fisher Scientific, Ausitn, TX ThP 60 Analysis of Volatile Organic Compounds in Crude Oil using High Resolution Orbitrap GC/MS; Aikaterini Kondyli ; Wolfgang Schrader ; Max-Planck Inst für Kohlenforschung., Mülheim / Ruhr, Germany ThP 6 Metabolic Profiling of Arabidopsis Tissue Extract using GC-MS/MS Technology ; Feroza Choudhury ; Amit Gujar ; Amith Reddy ; Ron Mittler ; Vladimir Shulaev ; University of North Texas, Denton, TX; Thermo Fisher Scientific, Austin, TX, USA ThP 6 Analysis of Trimethylsilyl Derivatives of Cyanogenic Glycosides from Flaxseed (Linum usitatissimum) by GC/MS; Tao Fan ; Véronique J. Barthet ; Canadian Grain Commission, Winnipeg, Manitoba; Canadian Grain Commission, Winnipeg, Canada ThP 6 Gas Chromatography- & Liquid Chromatography-Mass Spectrometry-Based Metabolomics: Effects of Altered Extracellular ph on Cancer Metabolism; Kristopher Kirmess ; Jan R Crowley ; Kevin Yarasheski ; Joseph Ippolito ; Washington University in St. Louis, St. Louis, MO ThP 64 Quantitative GC-MS/MS Analysis of Bisphenols with Oxycarbonyl Derivatization; Fred Bjorn Lih ; Deirdre K Tucker ; Sue E Fenton ; Leesa J Deterding ; NIEHS / NIH, RTP, NC ThP 65 Detecting Toxic Byproducts from Pyrotechnic Reactions via Pyrolysis/Gas Chromatography/Mass Spectrometry Techniques; Douglas Papenmeier ; Steven C. Weddle ; Eric J. Miklaszewski ; Caroline K. Wilharm ; Matthew A. Neiswinger ; Jonathan M. Dilger ; Special Warfare and Expeditionary Systems Department, Naval Surface Warfare Center, Crane Division, Crane, IN; Spectrum Warfare Systems Department, Naval Surface Warfare Center, Crane Division, Crane, IN; Science Applications International Corporation (SAIC), Crane, IN ThP 66 A Novel Ladder Approach for the Characterization of Diisonoyl Phthalate using GC-MS; Ian W. Shaffer ; Josh Allen Wilhide ; William R. LaCourse ; University of Maryland, Baltimore County Baltimore, MD ThP 67 Transition Metal Catalyzed Lignin Hydrotreatment and Determination of Products by GC-MS and Thermal Carbon Analysis; Honza Bilek; University of North Dakota, Grand Forks, ND ThP 68 Rapid On Site Analysis of BTEX Aromatics with a Miniaturized Field Portable Gas Chromatograph-Mass Spectrometer; Alan Gallaspy ; Frank Kero ; PerkinElmer, Oak Brook, IL; PerkinElmer, Waltham, MA ThP 69 Isobutane Made Practical as a Reagent Gas for Chemical Ionization Mass Spectrometry; G. Asher Newsome ; F. Lucus Steinkamp ; Braden C. Giordano ; Nova Research, Inc, Alexandria, VA; National Research Council, Washington, DC; U.S. Naval Research Laboratory, Washington, DC ThP 70 Comparison of Headspace Methods for GC/MS Analysis of Foods; Adam J. Patkin ; Sharanya Reddy ; David Scott ; Leeman Bennington ; Lee Marotta ; PerkinElmer, Shelton, CT ThP 7 Unambiguous Identification of Reaction Products from Conversion of Nitric Oxide over Novel Photocatalyst Surfaces; Ian G. M. Anthony ; Matthew R Brantley ; Adam R Floyd ; Abayomi D. Olaitan ; Deniz A Erdogan ; Emrah Özensoy ; Touradj Solouki ; Baylor University, Waco, TX; Bilkent University, Bilkent University Bilkent Ankara, Turkey H/D Exchange: Protein Structure/Function (Part ) 7-95 ThP 7 Lamin A (LmnA)-induced Conformational Changes of AIMP (aminoacyl-trna Synthetases-Interacting Multifunctional Proteins) Revealed by H/D Exchange FT-ICR MS; Yeqing Tao ; Pengfei Fang ; Nicolas L Young ; Min Guo ; Alan G Marshall, ; Florida State University, Tallahassee, FL; The Scripps Research Institute, Jupiter, Florida; NHMFL, Tallahassee, Fl ThP 7 Insights into Dynamics of SufBCD Fe-S Scaffold Complex by Hydrogen Deuterium Exchange Mass Spectrometry; Siqi Guan ; Guanchao Dong ; Wayne Outten ; Patrick Frantom ; University of Alabama, Tuscaloosa, AL; University of South Carolina, Columbia, SC ThP 74 HDX-MS Reveals Co-Regulation of Vitamin D Receptor/ Retinoic X Receptor Alpha Heterodimer Activation by Selective VDR Modulator and VDRE Sequence Specificity; Jie Zheng ; Bruce D Pascal ; Scott Novick ; Ruben D Garcia-Ordonez ; Pat Griffin ; The Scripps Research Institute, Jupiter, FL ThP 75 Probing the Structural Dynamics of the Prokaryotic Amino Acid Transporter LeuT by Hydrogen/Deuterium Exchange Mass Spectrometry; Patrick Sascha Merkle ; Kamil Gotfryd ; Ulrik Gether ; Claus Juul Løland ; Kasper Dyrberg Rand ; Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark; Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark ThP 76 ph Modulation of Myristate Exposure in the Human Immunodeficiency Virus Type- Matrix Protein: A Hydrogen Deuterium Exchange Mass Spectrometry Study; Ioannis Karageorgos, ; Kerry Bauer, ; Jeffrey W Hudgens, ; National Institute of Standards & Technology, Rockville, MD; Institute for bioscience and Biotechnology Research, Rockville, MD ThP 77 Calcium-Mediated Interactions of S00A with Annexin Peptides Probed by HDX-MS and MD Simulations; Yiming Xiao ; Gary S. Shaw ; Lars Konermann ; University of Western Ontario, London, ON; University of Western Ontario, London, Ontario (ON) 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 69

170 GENERAL THURSDAY INFORMATION POSTERS ThP 78 Gas-phase Hydrogen Deuterium Exchange as a Structural Probe: Assessing Similarities in Gas- and Solution-Phase Peptide Structures; Mahdiar Khakinejad ; Samaneh Ghassabi-Kondalaji ; stephen J Valentine ; West Virginia University, Morgantown, WV ThP 79 HDX-MS to Map the Allosteric Site for Efavirenz, a Drug that Stimulates Cholesterol-Metabolizing P450 CYP46A Activity; Kyle W Anderson, ; Natalia Mast ; Jeffrey W Hudgens, ; Joseph Lin ; Illarion V Turko, ; Irina A Pikuleva ; National Institute of Standards and Technology, Gaithersburg, MD; Institute for Bioscience and Biotechnology Researc, Rockville, MD; Case Western Reserve University, Cleveland, OH ThP 80 Characterization of Conformation of Therapeutic Antibody Aggregation with Optimized Hydrogen/ Deuterium Exchange Mass Spectrometry; Shanhua Lin ; Terry Zhang ; David M Horn ; Stephane Houel ; Xiaodong Liu ; Jonathan L Josephs ; Thermo Fisher Scientific, Sunnyvale, CA; Thermo Fisher Scientific, San Jose, CA ThP 8 Rapid Mapping of Antigen-Antibody Binding Sites utilizing Oxidative Footprinting and New Software; Yining Huang ; Ke Sherry Li ; Manolo D. Plasencia ; Henry W Rohrs ; Michael L Gross ; Yong J Kil ; Marshall W. Bern ; Eric Carlson ; Chris Becker ; Washington University in St. Louis, St. Louis, MO; Protein Metrics Inc., San Carlos, CA ThP 8 Conformational Characterization of Nerve Growth factor-β and the Impact of Its Regulatory Pro-Part Domain; Esben Trabjerg, ; Fredrik Kartberg ; Søren Christensen ; Kasper D. Rand ; Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark; H. Lundbeck A/S, Valby, Denmark ThP 8 Time-Resolved Hydrogen Deuterium Exchange Reveals the Structural Basis of Amyloidogenesis Inhibition by Alzheimer s Drug Candidates; Shaolong Zhu ; Bin Deng ; Braden Sweeting ; Marcy Taylor ; Mark Reed ; Derek J. Wilson ; York University, Toronto, Ontario; York University, Toronto, Canada; Treventis Corporation, Toronto, Canada ThP 84 Equilibrated and Kinetic Epitope Mapping for Therapeutic Antibodies by Time-Resolved ElectroSpray Ionization Hydrogen Deuterium exchange (TRESI-HDX) Mass Spectrometry; Bin N/A Deng ; Shaolong N/A Zhu ; Cristina N/A Lento ; Derek J. Wilson ; York University, Toronto, Canada ThP 85 Conformational Changes in the Regulatory Domains of the Tec-family Tyrosine Kinase Btk upon Lipid Interaction; Thomas E. Wales ; Raji E. E Joseph ; Amy H. H Andreotti ; John R. R Engen ; Northeastern University, Boston, MA; Iowa State University, Ames, IA ThP 86 Probing Protein Surface Chemistry and Unfolding Pathways by Coupling Gas-Phase HDX and Native MS; Shane A Chandler ; Todd H Mize ; Michael R Morris ; Justin L. P. Benesch ; Oxford University, Oxford, UK; Waters, Wilmslow, UK ThP 87 Deprotection by Interaction in HXMS: A Glimpse into a Highly Dynamic Cellulolytic System; Alan Kadek, ; Daniel Kavan, ; Roland Ludwig ; Petr Halada ; Petr Man, ; Institute of Microbiology CAS, Prague, Czech Republic; Faculty of Science, Charles University in Prague, Prague, Czech Republic; University of Natural Resources and Applied Life Sciences (BOKU), Vienna, Austria ThP 88 HDX/MS of the E. coli Replicative DNA Polymerase Identifies Stabilizing Interactions between the DNA Sliding Clamp, Exonuclease and Clamp Loader; Rafael Fernandez Leiro ; Sarah Louise Maslen ; Meindert H Lamers ; Mark Skehel ; MRC Laboratory of Molecular Biology, Cambridge, UK; Medical Research Council, Cambridge, Cambridgeshire ThP 89 Protein Footprinting and Mass Spectrometry Map the Interface of Marburg virus VP4 interacting with Keap; Jing Li ; Britney Johnson ; Daisy W Leung ; Christopher F Basler ; Gaya K Amarasinghe ; Michael L Gross ; Washington University in St. Louis, St. Louis, MO; Washington University School of Medicine, St. Louis, MO; Mount Sinai School of Med, New York, NY ThP 90 HDX-MS Characterization of Selective Modulators for Retinoic-acid Receptor-related Orphan Receptor RORγt in Protective Immune Therapy; Venkat Dharmarajan ; Scott Novick ; Mi Ra Chang ; Christelle Doebelin ; Ruben Garcia-Ordonez ; Ted Kamenecka ; Pat Griffin ; The Scripps Research Institute, Jupiter, Florida, Jupiter, FL; The Scripps Research Institute, Jupiter, FL ThP 9 Probing Cadherin Adhesive Interactions by Hydrogen/ Deuterium Exchange with Positive Electrospray 4.5 T FT-ICR Mass Spectrometry; Peilu Liu ; Samantha Davila ; Susan Diane Pedigo ; Alan G Marshall, 4 ; National High Magnetic Field Lab, Tallahassee, Florida; Department of Chemistry and Biochemistry, University of Mississippi, University, MS; National High Magnetic Field Laboratory, Tallahassee, FL; 4 Florida State University, Tallahassee, FL ThP 9 Conformation-specific Interactions with Tomm4 Modulate Hsp70 Folding and ATPase Activities; Jiri Hausner, ; Michal Durech ; Filip Trcka ; Dominika Coufalova ; Daniel Kavan, ; Petra Dvorakova ; Lenka Hernychova ; Elizabeth A. Blackburn 4 ; Petr Man, ; Petr Muller ; Borivoj Vojtesek ; Institute of Microbiology CAS, Prague, Czech Republic; Faculty of Science, Charles University in Prague, Prague, Czech Republic; RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic; 4 Edinburgh Centre for Chemical Biology, University of Edinburgh, Edinburgh, UK ThP 9 Beyond Structure Characterization: Structure Dynamics (Hydrogen deuterium exchange) Guided Biocatalyst Improv; Susie Dai; Office of the Texas State Chemist, Department of V, College Station, TX ThP 94 Structure and Dynamics of RNA Binding to the Non- Canonical RNA Recognition Motif (RRM) in Human La Protein; Kerene Brown ; Mark Bayfield ; Derek Wilson ; York University, Toronto, Ontario; York University, Toronto, Canada ThP 95 Determination of Site-specific Protein-Ligand Binding Affinities using Protein Ligand Interaction Mass Spectrometry Titration and Hydrogen Deuterium Exchange (PLIMSTEX) Strategy; Jagat Adhikari ; Don L. Rempel ; Michael L Gross ; Washington University in St. Louis, St Louis, MO; Washington University in St. Louis, St Louis, MO Imaging MS: Method Development (MALDI) 96-5 ThP 96 Regional Analysis of Anacardic Acids on the Surface of Pelargonium xhortorum (Geranium) Leaves using MALDI-MSI with a New Stable Matrix; Marta Yappert ; Bryan Wessel ; David Schultz ; Department of Chemistry, University of Louisville, Louisville, KY; Department of Biology, University of Louisville, Louisville, KY ThP 97 Method Development for Imaging Mass Spectrometry on Dense Mineralized Tissue of Mouse Incisors; Madeline Colley ; Yong-Hee Patricia Chun ; Stephan BH Bach ; University of Texas at San Antonio, San Antonio, TX; UT Health Science Center at San Antonio, San Antonio, TX ThP 98 MALDI-MSI for the Study of Flow-Cell and Agar Bound Microbial Biofilms; Bin Li ; Sage Dunham ; Tong Si ; Ning Yang ; Clint Arnett ; Sweedler Jonathan ; University of Illinois at Urbana-Champaign, Urbana, IL; University of Illinois at Urbana-Champaign, Urbana-Champaign, IL; Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL), Champaign, IL PAGE TH ASMS CONFERENCE ON MASS SPECTROMETRY

171 THURSDAY POSTERS ThP 99 Microscopic MALDI-imaging Mass Spectrometry in Intestinal Tumors of Apc Mutant Mice using Two-Step Matrix Application; Shuichi Shimma, ; Satoko Osawa, ; Masahiro Aoki, 4 ; Yasushi Kojima, 4 ; Tomoyoshi Soga, 5 ; Osaka Univerisity, Suita, Osaka; AMED-CREST, Tokyo, Japan; Osaka University, Suita, Japan; 4 Aichi Cancer Center, Nagoya, Japan; 5 Keio University, Tsuruoka, Japan ThP 00 Imaging of Lipids using,6 Dihydroxyacetophone Matrix with an AP-MALDI Source; Ludovic Muller ; Shelley N Jackson ; Aurelie Roux ; Berk Oktem ; Vladimir M Doroshenko ; Amina S Woods ; NIH/NIDA-IRP, Baltimore, MD; All Children s Hospital Johns Hopkins Medicine, Saint Petersburg, FL; MassTech, Inc. Columbia, MD ThP 0 Enhanced On-Tissue Analyte Derivatization with Electrospray Deposition of Reagents for MALDI MS Imaging of Neurotransmitters ; Qian Wu ; Stanislav S. Rubakhin ; Troy J. Comi ; Jonathan V. Sweedler ; University of Illinois at Urbana-Champaign, Urbana- Champaign, IL ThP 0 MALDI FTICR-IMS of a Mouse Lung for D Imaging and Reconstruction; E. Ellen Jones ; Stephanie Dale ; Katherine A Kellersberger ; Christian Berg ; Cristine Quiason ; Sheerin Shahidi-Latham ; Genentech Inc, South San Francisco, CA; Bruker Daltonic, Billerica, MA ThP 0 From D to D MALDI Imaging Mass Spectrometry - Reconstruction of a Multimodal Imaged Epididymis; Regis Lavigne ; Blandine Guevel ; Michael Becker ; Janine Beckmann ; Dennis Trede ; Herbert Thiele 4 ; Melanie Lagarrigue ; Charles Pineau ; Protim, Irset, Inserm U.085, Rennes, France; Bruker Daltonic GmbH, Bremen, Germany; SCiLS GmbH, Bremen, Germany; 4 Fraunhofer MEVIS Project Group Image Registration, Lübeck, Germany ThP 04 Quantitative MALDI-MS Imaging of Tumour Spheroids ; Rebecca Day ; Laura Cole ; Ieva Palubeckaite ; David Smith ; Neil Cross ; Malcolm R Clench ; Sheffield Hallam University, Sheffield, UK ThP 05 MALDI Directed Infrared Laser Ablation Sample Transfer for Spatially Resolved Biomolecule Analysis; Kelin Wang ; Fabrizio Donnarumma ; Kermit K Murray ; Louisiana State Univeristy, Baton Rouge, LA ThP 06 In-parallel MS and MS/MS MALDI Imaging without Sacrificing Spatial Resolution; Rebecca Hansen, ; Young Jin Lee, ; Iowa State University, Ames, IA; Ames Laboratory-US DOE, Ames, Iowa ThP 07 MALDI Imaging-Driven Microproteomics Workflow for Biomarker Discovery Assays; Deborah Alberts ; Rémi Longuespée ; Charles Pottier ; Nicolas Smargiasso 4 ; Gabriel Mazzucchelli 5 ; Dominique Baiwir 6 ; Philippe Delvenne ; Fabien Pamelard 7 ; Gaël Picard de Muller 7 ; Edwin De Pauw 4 ; Mass Spectrometry Laboratory, University of Liege, Liège, Belgium; Proteopath GmbH, Trier, Germany; Department of pathology, University of Liège Liège, BELGIUM; 4 Mass Spectrometry Laboratory, University of Liege, Liege, Belgium; 5 Mass Spectrometry Laboratory, University of Liege, Liege, Belgium; 6 GIGA Proteomics Facility, University of Liège Liège, Belgium; 7 ImaBiotech, Lille, France ThP 08 Method Development on a MALDI Orbitrap Platform to Achieve High Throughput in situ DDA Analysis via Multiplex Mass Spectrometric Imaging; Chuanzi Ouyang ; Bingming Chen ; Lingjun Li ; University of Wisconsin Madison, Madison, WI ThP 09 A Rapid, Cell Culture-Based Method for Biomarker Discovery and Drug Screening by MALDI-MSI; Courtney E Chandler ; Alison J Scott ; George A. Belov ; David R Goodlett ; Shane Ellis ; Robert K Ernst ; University of Maryland Baltimore, Baltimore, MD; University of Maryland, College Park College Park, MD; Maastricht University, Maastricht, NL ThP 0 Histology-Directed Lipid Identification: Advanced Imaging Mass Spectrometry and Liquid Extraction Technologies Enable Spatially Specific Tandem Mass Spectrometry; Daniel Ryan ; Boone Prentice ; Raf Van de Plas ; Jeffrey Spraggins ; Richard M Caprioli ; Vanderbilt University, Nashville, TN; Delft University of Technology, Delft, Netherlands ThP Bottom-up Imaging of Prostate-Cancer Protein Biomarkers by MCAEF (Matrix Coating Assisted by an Electric Field)-LDI/FTMS; Teesha C Baker ; Jun Han ; Darryl B Hardie ; Christoph H. Borchers, ; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; University of Victoria - Genome BC Proteomics Centre, Victoria, BC ThP MALDI Imaging for the Quantification of Small Molecules and the Understanding of Toxicity Mechanisms; Melanie Lagarrigue ; Régis Lavigne ; Andrew Palmer ; Charles Pineau 4, 5 ; Protim, Rennes, Brittany; Protim - Irset Inserm U 085, Rennes, France; EMBL, Heidelberg, Germany; 4 Protim, IRSET Inserm U085, Rennes, France; 5 University Rennes, Rennes, France ThP An Investigation of MALDI Imaging with Higher Speed Sample Stage Rastering from an Ion Mobility Enabled Q-TOF Mass Spectrometer; Towers Mark ; Paul Murray ; Migas Lukasz ; Claude Emmanuelle ; Hoyes Emmy ; Chapman Richard ; Waters, Wilmslow, UK; University of Manchester, Manchester, UK ThP 4 High-Throughput Single Cell Analysis using High Spatial Resolution and High Sensitivity Imaging Mass Spectrometry; Bo Yang ; Jeffrey M Spraggins ; Richard M Caprioli ; Jeremy L Norris ; Vanderbilt University MSRC, Nashville, TN ThP 5 Loblolly Pine Seedling Imaging Analysis by DESI-MS and MALDI-MS; Michelle Reid ; Gary F Peter ; Richard A Yost ; University of Florida, Gainesville, FL Imaging MS: Small Molecules 6-47 ThP 6 Exploring the Chemical Ecology of Fungi via Secondary Metabolite Distribution; Vincent Sica ; Huzefa Raja ; Cedric Pearce ; Nicholas H Oberlies ; UNC - Greensboro, Greensboro, NC; Mycosynthetix, Hillsborough, NC ThP 7 Microbial Metabolite and Lipid Analysis by Imaging Laser Desorption Ionization Mass Spectrometry on Silicon Nanopost Array Platforms; Rachelle Jacobson ; Akos Vertes ; George Washington University, Washington, District of Columbia ThP 8 Optimizing the Production of Fungal Epipolythiodioxopiperazine Alkaloids Facilitated by Rapid Analysis via the droplet-lmj-ssp Coupled with UPLC-PDA-HRMSMS/MS; Soumia Amrine ; Huzefa Raja ; Cedric Pearce ; Nicholas Oberlies ; UNC Greensboro, Greensboro, NC; Mycosynthetix, Hillsborough, NC ThP 9 Profiling Secondary Metabolites from a Culture Evaluation of Penicillium restrictum with Droplet-Liquid Microjunction Surface-Sampling Probe; Diana Kao; University of North Carolina at Greensboro, Greensboro, NC ThP 0 MALDI-FTMS Imaging Reveals Secondary Metabolites Produced during Interaction of Micro-Organisms with Higher Organisms; Dirk Wunderlich ; Jens Fuchser ; Stephanie Grond ; Florian Zubeil ; Dorothee Wiesbrod ; Bruker Daltonics, Bremen, Bremen; Bruker Daltonic GmbH, Bremen, Germany; Eberhard Karls University Tübingen, Tübingen, Germany ThP Mass Spectrometry Imaging of Curtobacteriumsp. ER/6, an Endophytic Bacterium with Potential Biocontrol against Citrus-Variegated Chlorosis; Francisca D. S. Araújo ; Daiene S. Santos ; Welington L. 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY PAGE 7

172 GENERAL THURSDAY INFORMATION POSTERS Araujo ; Marcos N Eberlin ; Unicamp, Campinas, SP; University of São Paulo, São Paulo, SP ThP Imaging Mass Spectrometry of S-containing Metabolites in Asparagus officinalis; Ryo Nakabayashi ; Tetsuya Mori ; Hiroshi Sudo ; Kiminori Toyooka ; Kazuki Saito, ; RIKEN Center for Sustainable Resource Science, Yokohama, Japan; Hoshi University, Shinagawa, Japan; Chiba University, Chiba, Japan ThP MALDI Imaging Mass Spectrometry Revealed the Different Distribution Patterns of Anthocyanin Species in Strawberry; Hirofumi Enomoto ; Ryosuke Sato ; Hisakazu Yamane ; Fumiaki Yoshizawa ; Teikyo University, Utsunomiya, Japan; Utsunomiya University, Utsunomiya, Japan ThP 4 Three-Dimensional Visualization of Membrane Phospholipid Heterogeneity in Arabidopsis thaliana seeds by MALDI-MS Imaging; Drew Sturtevant, ; Maria Dueñas, 4 ; Young Jin Lee, 4 ; Kent D. Chapman, ; University of North Texas, Denton, TX; Center for Plant Lipid Research, Denton, TX; Iowa State University, Ames, IA; 4 Ames Laboratory-US DOE, Ames, IA ThP 5 Spatial Distribution of Lipids in Coffee Leaves (Coffea arabica) using MALDI Imaging Mass Spectrometry; Karen T. Henández-Osorio ; Jeferson A. Valencia- Dávila ; Cristian Blanco-Tirado ; Marianny Y. Combariza ; Universidad Industrial de Santander, Bucaramanga, Santander, Colombia ThP 6 Localization of the Salvinorin A diterpenoid Pathway in Savia divinorum by MALDI-FTICR-MS Imaging; Jeong Jin Park ; Xiaoyue Chen ; Anna Berim ; Jing Wang ; David R. Gang ; Washington State University, Pullman, WA ThP 7 Imaging Non-uniform Spatial Distribution of Energy Dense Metabolites for Efficient Capture and Chemical Storage of Solar Energy by Plants; Bo Xie ; Liza Alexander, ; Jennifer Chmielowski ; Basil J. Nikolau, ; Ames Laboratory-US DOE, Ames, IA; Iowa State University, Ames, IA ThP 8 Imaging Mass Spectrometry Revealed Distributions of Anthocyanin Species in Haskap; Takahiro Hayasaka ; Miwako Sugawara ; Masafumi Kudo ; Hitoshi Chiba ; Shu-Ping Hui ; Hokkaido University, Sapporo, Hokkaido; Northern Advancement Center for Science & Technology, Sapporo, Japan; Hokkaido University, Sapporo, Japan ThP 9 Maldi Imaging of Alkaloids in Catharanthus roseusleaves; Lorenzo Caputi ; Gerhard Saalbach ; Sarah E. O Connor ; John Innes Centre, Norwich, UK ThP 0 Development of Laser Ablation Direct Analysis in Real Time Imaging Mass Spectrometry (LADI-MS); Rabi Musah ; Kristen L Fowble ; University at Albany-SUNY, Albany, NY ThP Mass Spectrometry Imaging Enhances Biochemical Pathway Elucidation; David Gang ; Park Jeong-Jin ; Willis Mark ; Jing Wang ; Washington State University, Pullman, WA ThP Matrix Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Glycosphingolipids in Rat Eye Tissue: Method Development and Optimization; Gargey B. Yagnik ; Mandy Cromwell ; Alexander Brezzani ; Kelly Keefe ; Mark Bree ; Dinesh Bangari 4 ; Petra Oliva 5 ; Thomas O Shea ; Hanlan Liu ; Drug Metabolism and Pharmacokinetics, Sanofi, Waltham, MA; Rare Disease Pharmacology, Sanofi, Waltham, MA; Preclinical Toxicology, Sanofi, Waltham, MA; 4 Pathology, Sanofi, Framingham, MA; 5 Biological Mass Spectrometry, Sanofi, Framingham, MA ThP Sub Micrometric D Analysis of Mosquito Ovaries using TOF-SIMS Imaging; Quentin Vanbellingen ; Anthony Castellanos ; Marcela Nouzova ; Fernando G. Noriega ; Francisco Fernandez-Lima ; Florida International University, Miami, FL ThP 4 Three Dimensional MALDI-MS Imaging of a Single Cell Zebrafish Embryo; Maria Emilia Dueñas, ; Adam Feenstra, ; Jeffrey Essner ; Young Jin Lee, ; Iowa State University, Ames, IA; Ames Laboratory-USDOE, Ames, IA ThP 5 The Embryome: Molecules in Space and Time During the Early Stage Development; Laszlo Mark,, ; Janos Schmidt, ; Department of Analytical Biochemistry, Institute of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Pecs, Hungary; PTE-MTA Human Reproduction Research Group, Pecs, Hungary; Imaging Center for Life and Material Sciences, University of Pecs, Pecs, Hungary ThP 6 Optimisation of Matrix Condition for theanalysis of the Antifungal Agent (Terbinafine hydrochloride) in a Living Skin Equivalent Model; Cristina Russo ; Malcolm R Clench ; Neil Bricklebank ; Catherine Duckett ; Stephen Mellor ; Stephen Rumbelow 4 ; Sheffield Hallam University, Sheffield ; Sheffield Hallam University, BMRC Sheffield, UK; Croda Europe Ltd, Snaith, UK; 4 Croda Inc, New Castle, DE ThP 7 Benchmarking New GCIB-SIMS Technology against MALDI and Applying GCIB-SIMS to Study Myocardial Infarction; Amir Saeid Mohammadi ; Sanna Sämfors ; Andrew G Ewing, ; John Fletcher ; Chalmers University of Technology, Gothenburg, Sweden; University of Gothenburg, Gothenburg, Sweden ThP 8 Mass Spectrometric Imaging of a Three-Dimensional Osteosarcoma Model; Ieva Palubeckaite ; Neil Cross ; Malcolm R Clench ; Christine Le Maitre ; Sheffield Hallam University, Sheffield, UK ThP 9 The Effects of Diets on rat Brain Regional Lipid Composition using GCIB-SIMS; Amir Saeid Mohammadi ; Alastair Ross ; John S Fletcher ; Andrew G Ewing, ; Chalmers University of Technology, Gothenburg, Sweden; University of Gothenburg, Gothenburg, Sweden ThP 40 Specific Isotopic Pattern of Brominated Pyrylium Salts Facilitates Mass Spectrometry Imaging and Identification of Derivatized Small Molecule Neuroactive Compounds; Mohammadreza Shariatgorji ; Anna Nilsson ; Per E Andren ; Uppsala University, Uppsala, Sweden ThP 4 MALDI Imaging with High Spatial Resolution for the Direct Analysis of Phospholipids in Rat Brain Tissue; Simona Salivo ; Yuzo Yamazaki ; Omar Belgacem ; Peter Quinto Tranchida ; Luigi Mondello ; University of Messina, Messina, Italy; Shimadzu Corporation, Kyoto, Japan; Shimadzu, Kratos Manchester, UK ThP 4 MALDI-TOF Imaging Mass Spectrometry Reveals a Massive Loss of Polyunsaturated Cardiolipins after Traumatic Brain Injury; L.J. Sparvero ; Andrew A Amoscato ; Arthur B. Fink ; Tamil Anthonymuthu ; Simon Watkins ; Valerian E. Kagan ; Hulya Bayir ; University of Pittsburgh, Pittsburgh, PA; University of Pittsburgh, Pittsburgh, PA ThP 4 Compounds Screening in Dosed Human Skins by Quantitative Mass Spectrometry Imaging; David Bonnel ; Sylvain Ghilini ; Raphael Legouffe ; Claude Verrier ; Gael Picard-de Muller ; Marie-José Cuadrado ; Fabien Pamelard ; Gregory Hamm ; Jonathan Stauber ; ImaBiotech, MS Imaging Dept. Loos, France; Galderma, Sophia-Antipolis, France ThP 44 Imaging of Drugs and Lipids in Living Skin Equivalents by MALDI MS and SIMS; Josephine Bunch ; Rory Steven ; Alan Race ; National Physical Laboratory, Teddington, UK ThP 45 Adjustable Hydrophobic GUMBOS Matrices for MALDI Mass Spectral Imaging; Tia Vargas ; Kermit K Murray ; Isiah M Warner ; Louisiana State University, Baton Rouge, LA ThP 46 Evaluating DESI Imaging and High Resolution Mass Spectrometry to Improve an Industrial Component Cleaning Process; Peter Hancock ; Jonathan Jones ; PAGE 7 64 TH ASMS CONFERENCE ON MASS SPECTROMETRY

173 THURSDAY POSTERS Eleanor Riches ; Vikki Turner ; Gordon Jones ; Timothy Harford ; Waters, Wilmslow, UK ThP 47 Surface Imaging of Polymers and Polymer Additives with TOF-SIMS Parallel Imaging MS/MS; John Hammond ; Gregory L Fisher ; Paul Larson ; Scott Bryan ; Physical Electronics, Chanhassen, MN Informatics: General, SRM, and DIA ThP 48 A Glycan Structure MS/MS Search Platform in Python; Joshua Klein ; Kshitij Khatri ; Yi Pu ; Lin Cheng ; Joseph Zaia ; Boston University Program for Bioinformatics, Boston, MA; Boston University, Boston, MA ThP 49 Automatic Quality Assessment of Mass Spectrometry Experiments by Multivariate Quality Control Metrics and the Relation between Low-Quality Experiments and Identifications; Wout Bittremieux ; Pieter Meysman ; Lennart Martens ; Dirk Valkenborg ; Kris Laukens ; University of Antwerp, Antwerp, Belgium; Ghent University, Ghent, Belgium; VITO, Mol, Belgium ThP 50 Spectrum Acquisition for Building the NIST Tandem MS Library; Yuxue Liang ; Pedatsur Neta ; Xiaoyu Yang ; Stephen Stein ; National Institute of Standards and Technology, Gaithersburg, MD; NIST, Rockville, MD ThP 5 DIAprobe Implementation of a Statistical Tool for Data Independent Acquisition in Skyline for SWATH Analysis; Alexandria DSouza ; Birgit Schilling ; Bradford W Gibson ; Buck Institute for Research on Aging, Novato, CA ThP 5 Automated Design of Optimal SRM &PRM Assays using Empirical Modular Models; Jerome Renaux ; Alexandros Sarafianos; Kurt De Grave; Jan Ramon ; KULeuven, Heverlee, Vlaamse Brabant; KU Leuven, Leuven, Belgium ThP 5 PTM-Annotator: A Python Library for Annotation of Post-Translation Modification from Proteomic Mass Spectrometry Analysis; Amin Momin ; Hailey E Haut ; Michela Capello ; Juan Chen ; Hong Wang ; Samir M Hanash ; MD Anderson Cancer Center, Houston, TX ThP 54 Proteomic Sequencing and Resurrection of a Monoclonal Antibody; Natalie Castellana ; Kexin Huang ; Hua Tu ; Digital Proteomics, LLC., San Diego, CA; LakePharma, Inc., Belmont, CA ThP 55 MADpipe An MRM Assay Design PIPEline for Multiplexed Multiple and Parallel Reaction Monitoring (MRM and PRM) Experiments; Yassene Mohammed, ; Derek S Smith ; Dominik Domanski, ; Angela M Jackson ; Andrew Percy ; Andrew G Chambers ; Andrea Palmer 4 ; Suping Zhang 4 ; Christoph H. Borchers 5, 6 ; University of Victoria - Genome BC Proteomics Centre, Victoria, BC, Canada; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands; Segal Cancer Proteomics Center, Lady Davis Institute, McGill University, Montreal, QC, Canada; 4 MRM Proteomics, Inc., Victoria, BC, Canada; 5 University of Victoria - Genome BC Proteomics Centre, Victoria, BC; 6 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada ThP 56 Scout-MRM: Extended Portability of Large Multiplexed Peptide Assay; Blandine Rougemont ; Romain Carriere ; Sophie Ayciriex ; Jean Marie Lacroix ; David Cox ; Yves J C LeBlanc ; Jérôme Lemoine ; Institut des Sciences Analytiques, UMR 580 CNRS, Université de Lyon, Villeurbanne, France; UGSF UMR Lille/CNRS 8576, Villeneuve D ascq Cedex, France; SCIEX, Concord, ON ThP 57 EasyCont: Identify Contaminants On-Line for Free on ms.cheminfo.org; Daniel Ortiz ; LAURE MENIN ; Luc Patiny ; EPFL, Lausanne, Switzerland ThP 58 BioDocker: An Open Source and Community-Driven Framework for Software Standardization in Proteomics; Felipe da Veiga Leprevost ; Saulo Alves Aflitos ; Björn Grüning ; Hannes Roest 4 ; Harald Barsnes 5 ; Rafael Jimenez 6 ; Henning Hermjakob 6 ; Alexey I. Nesvizhskii ; Yasset Perez-Riverol 6 ; University of Michigan, Ann Arbor, MI; Wageningen University, Wageningen, The Netherlands; University of Freiburg, Freiburg, Germany; 4 Stanford University School of Medicine, Palo Alto CA, USA; 5 University of Bergen, Bergen, Norway; 6 EMBL-EBI, Hinxton, UK ThP 59 CRAPome.0: A Comprehensive Resource for Affinity Purification Mass Spectrometry Data; Dattatreya Mellacheruvu ; Zachary Wright ; Anne-Claude Gingras ; Alexey I Nesvizhskii ; University of Michigan, Ann Arbor, MI; Samuel Lunenfeld Research Institute, Mount Sinai H Toronto, ON ThP 60 Without Sacrificing Dwell Time, Achieving /N Smaller SWATH Windows (N = Number of MS Samples) to Quantify Low-Abudance Ions; GAUTAM SAXENA ; Vidya Venkatraman ; Sarah Parker ; Ronald Holewinski ; Jennifer E Van Eyk ; Deep Search, Bethesda, MD; Cedars-Sinai Medical Center, Los Angeles, CA - California ThP 6 Analysis of Data Independent Acquisition Mass Spectrometry Data with DIA-Umpire v; Chih-Chiang Tsou ; Chia-Feng Tsai ; Yu-Ju Chen ; Guoci Teo ; Anne- Claude Gingras ; Alexey Nesvizhskii ; University of Michigan, Ann Arbor, MI; Academia Sinica, Taipei, Taiwan; Lunenfeld Tanenbaum Research Institute, Toronto, Canada ThP 6 Proteomics for Ricin Bioforensics: Protein Content of Castor Seed Extracts and Related Informatics Approaches; Eric Merkley ; Alaine M. Garrett ; Kristin H Jarman ; Owen P Leiser ; Jennifer A Arce ; Kristin D Victry ; Angela M Melville ; David S. Wunschel ; Stephen R. Cendrowski ; Karen L Wahl ; Chemical and Biological Signature Sciences Group, Pacific Northwest National Laboratory, Richland, WA; National Biodefense Analysis and Countermeasures Center, Fort Detrick, MD; Applied Statistics and Mathematics Group, Pacific Northwest National Laboratory, Richland, WA ThP 6 Simulations Reveal the Pertinent Factors for High Quality Mass Spectrometry Based Microorganism Identification; Jan Eriksson ;

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